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a Related Biological Terms:

(see Holliday model)

In RNA splicing, the site to which the 5'-guanylate at the end of an intron is joined to an adenylate residue within the intron through a 2',5'-phosphodiester bond to form a 'lariat' intermediate. (see also self-splicing)

A single metabolite that is an intermediate in two or more biosynthetic pathways, e.g. pyruvate (a precursor of acetyl-CoA, alanine and oxaloacetate), chorismic acid (a precursor of phenylalanine, tryptophan and tyrosine).

The sequence near the 3'-end of an intron of nuclear mRNA that contains the adenosine residue which, as the intron is excised, will accept the guanosine residue at the 5'-end of the intron.(see also pre-mRNA splicing)Maniatis, T. (1991) Science 251, 33-34

A progenote; in early evolution, the first organism able to transmit genetic information, even if with only marginal fidelity. Benner, S.A. and Ellington, A.D. (1990) Science 248, 943-944

In evolutionary theory, the hit-or-miss recruitment and adaptation of pre-existing genes or materials for new functionsDuboule, D. and Wilkins, A.S. (1998) Trends Genet. 14, 54-59

Thermogenic fatty tissue with a high content of relatively uncoupled mitochondria; especially prominent in infants, located around the kidneys and neck.

Covalent reactions that occur on heating proteins; the formation of cross-links between side chains and with carbohydrates.

A measure of the ability of a solution to maintain its pH in the face of the addition of acid or alkali; a capacity of 1 when 1 mol of acid (or alkali) is added to 1 litre causes a pH fall (or rise) of 1 pH unit.

(= buffer capacity)

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