Cell Engineering Platform

Cell Engineering

Cell engineering is an important part of modern basic and translational life science research. At GenScript, we recognize that having strong cell engineering capabilities is critical in ensuring you meet your project milestones. In addition to our award winning gene synthesis services, we are proud to bring you a wide array of cell engineering platforms as well as accompanying technical expertise to help meet your project needs.

Service Highlights

Extensive Experience

One Stop Shop

CRISPR System License

Service Specifications

Case Studies

• ACLD Case Study
  

  Immune checkpoint test by luminescence

• CRISPR Case Study
  

  Safe harbor knock-in performance test

  

  Tag and monitor protein in situ with florescent proteins

• LVV Case Study
  

  Lentivirus transduction test

  Target cell: 293T         Titer: 7.8*10⁸ IFU/mL         Time: 72 hours after transduction         MOI: 20

Resources

• Who will need cell engineering?

  Empowered by GenScript’s CellPower™ and GenCRISPR™ services, we can provide cell engineering services from target screening to in vitro & in vivo assay.

  
• Why cell engineering is so important in bioprocessing?

  Cell engineering is mainly associated with the modifications and alterations of host cells for enhancing the yield and quality of the expressed protein. There are several approaches for altering the cellular processes such as silencing or overexpressing of targeted genes and altering expression of genes using microRNA. Cells are powerful therapeutic agents. Whether they are engineered or in their natural state, cells are increasingly utilized across a range of pathologies. Gene overexpressing and silencing are the major approach for cellular engineering. RNA interference is being used to silence multiple genes of different cellular pathways for optimum productivity of bioengineered proteins. New advanced tools that are currently used for gene editing are zinc finger nucleases, modified meganucleases, hybrid DNA/RNA oligonucleotides, Transcription Activator like (TAL) effector nucleases, and modified Clustered Regularly Interspaced Short Palindrome Repeats (CRISPR)/Cas9. With an expanding array of cell types now under investigation for the treatment of cancer, genetic disorders, infectious diseases, and degenerative disorders, GenScript is fostering cutting-edge research on emerging cellular therapies.

• Lentivirus introduction
  Lentivirus assist drug screening process

  GenScript offers proprietray lentiviral packaging platform to ensure you getting functional intact virus everytime.

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• CRISPR Webinar
  Featured Webinar | CRISPR Based CAR-T Cell Editing: Large gene knock-ins in human T cells using non-viral HDR templates

  Dr. Theo Roth from Marson Lab, UCSF
  He introduces the advantages of a new CRISPR based method that allows for the insertion of large DNA sequences (>1Kb) in primary T cells without a virus.

  Learn More
• White Paper
  

  CRISPR Handbook

  Enabling Genome Editing and Transforming Life Science Research

  Free Download

  

  Protein Service Handbook

  The Valuable Guide for Your Cell Engineering Research.

  Free Download

  Free Download