Parp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Parp1
Entrez Gene ID	25591
Full Name	poly (ADP-ribose) polymerase 1
Synonyms	ARTD1,Adprt,Parp-1
General protein information	Preferred Names poly (ADP-ribose) polymerase 1 Names poly [ADP-ribose] polymerase 1 ADP-ribosyltransferase (NAD+ ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) ADP-ribosyltransferase 1 ADP-ribosyltransferase diphtheria toxin-like 1 ADPRT 1 NAD(+) ADP-ribosyltransferase 1 poly (ADP-ribose) polymerase family, member 1 poly (ADP-ribose) polymerase) poly(ADP-ribose) polymerase PARP-1 poly[ADP-ribose] synthase 1 poly[ADP-ribose] synthetase 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q26
Summary	catalyzes poly (ADP-ribose) protein modification; plays a role in DNA repair and genome stability [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013063.2	NP_037195.1	poly [ADP-ribose] polymerase 1

Pathways from BioSystems

Homologies

Arabidopsis thaliana (thale cress)	PARP1	NP_850165.1
Oryza sativa (rice)	Os07g0413700	NP_001059453.1
Drosophila melanogaster (fruit fly)	Parp	NP_001104452.1
Homo sapiens (human)	PARP1	NP_001609.2
Pan troglodytes (chimpanzee)	PARP1	XP_003949754.1
Canis lupus familiaris (dog)	PARP1	XP_547506.3
Bos taurus (cattle)	PARP1	NP_777176.1
Macaca mulatta (Rhesus monkey)	PARP1	XP_001090984.1
Gallus gallus (chicken)	PARP1	NP_990594.1
Xenopus tropicalis (tropical clawed frog)	parp1	XP_002941174.2
Danio rerio (zebrafish)	parp1	NP_001038407.1
Caenorhabditis elegans (roundworm)	pme-1	NP_491072.1
Mus musculus (house mouse)	Parp1	NP_031441.2
Rattus norvegicus (Norway rat)	Parp1	NP_037195.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003230	XP_312938.4

Gene Ontology
Bibliography

Related articles in PubMed

PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy.
Li Q, Li ZM, Sun SY, Wang LP, Wang PX, Guo Z, Yang HW, Ye JT, Lu J, Liu PQ
Acta pharmacologica Sinica40(5)589-598(2019 May)

DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD
Zhang D, Hu X, Li J, Liu J, Baks-Te Bulte L, Wiersma M, Malik NU, van Marion DMS, Tolouee M, Hoogstra-Berends F, Lanters EAH, van Roon AM, de Vries AAF, Pijnappels DA, de Groot NMS, Henning RH, Brundel BJJM
Nature communications10(1)1307(2019 03)

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Liu H, Zhang H, Wu X, Ma D, Wu J, Wang L, Jiang Y, Fei Y, Zhu C, Tan R, Jungblut P, Pei G, Dorhoi A, Yan Q, Zhang F, Zheng R, Liu S, Liang H, Liu Z, Yang H, Chen J, Wang P, Tang T, Peng W, Hu Z, Xu Z, Huang X, Wang J, Li H, Zhou Y, Liu F, Yan D, Kaufmann SHE, Chen C, Mao Z, Ge B
Nature563(7729)131-136(2018 11)

PARP1 promote autophagy in cardiomyocytes via modulating FoxO3a transcription.
Wang C, Xu W, Zhang Y, Zhang F, Huang K
Cell death & disease9(11)1047(2018 10)

Hypochlorite modified albumins promote cell death in the tubule interstitium in rats via mitochondrial damage in obstructive nephropathy and the protective effects of antioxidant peptides.
Liu ZR, Chen SQ, Zou YW, Wu XY, Li HY, Wang XQ, Shi Y, Niu HX
Free radical research52(5)616-628(2018 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Parp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Parp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13363	NM_013063.2 Latest version!	Rattus norvegicus poly (ADP-ribose) polymerase 1 (Parp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Parp1 ( NM_013063.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037195.1 Rattus norvegicus poly (ADP-ribose) polymerase 1 (Parp1), mRNA.

Price & Availability↑

CloneID	ORa13363
Clone ID Related Accession (Same CDS sequence)	NM_013063.2
Accession Version	NM_013063.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3045bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Rattus norvegicus(Norway rat)
Product	poly [ADP-ribose] polymerase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085765.1. On Nov 15, 2004 this sequence version replaced NM_013063.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC085765.1, U94340.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGAGG CCACGGAGAG GCTTTACCGA GTGGAGTACG CTAAGAGCGG GCGCGCCTCT 
TGCAAGAAAT GCAGCGAGAG TATCCCCAAG GACTCGCTCC GCATGGCCAT CATGGTGCAG 
TCACCCATGT TCGATGGAAA AGTCCCACAC TGGTATCACT TCTCCTGCTT CTGGAAGGTG 
GGCCACTCCA TCCGGCAGCC TGACACAGAG GTGGACGGGT TCTCTGAGCT GCGGTGGGAT 
GACCAGCAGA AGGTCAAGAA GACCGCAGAG GCTGGAGGCG TGGCAGGCAA AGGCCAGCAT 
GGAGGTGGCG GCAAGGCGGA GAAGACGCTG GGCGACTTTG CGGCAGAGTA TGCCAAGTCC 
AACAGGAGCA CATGCAAGGG CTGCATGGAG AAGATAGAGA AGGGTCAGAT GCGCCTGTCC 
AAGAAGATGC TGGATCCAGA GAAGCCGCAA CTGGGTATGA TTGACCGCTG GTACCATCCA 
ACTTGCTTTG TCAAGAACCG GGACGAGCTG GGCTTCCGGC CTGAGTACAG TGCCAGCCAG 
CTCAAGGGCT TTAGCCTCCT CTCTGCAGAA GACAAAGAAG CTCTGAAGAA GCAGCTCCCG 
GCAGTCAAGA GTGAAGGAAA GAGAAAATGT GACGAGGTGG ATGGAATAGA TGAAGTAGCC 
AAAAAGAAAT CTAAAAAAGG AAAGGACAAG GAGAGTAGTA AACTGGAAAA GGCGCTCAAG 
GCTCAGAACG AGCTGGTCTG GAATATCAAA GATGAGCTGA AGAAAGCCTG CTCCACCAAC 
GACCTGAAGG AGTTGCTCAT CTTCAACCAG CAGCAAGTAC CATCTGGAGA GTCCGCAATC 
CTGGACCGAG TTGCTGATGG CATGGCGTTT GGGGCCCTTC TGCCCTGCAA GGAGTGTTCA 
GGACAGCTGG TTTTTAAGAG CGACGCTTAT TACTGTACTG GGGATGTCAC TGCCTGGACC 
AAGTGCATGG TCAAGACACA GAATCCCAGC CGAAAGGAAT GGGTAACTCC AAAGGAATTC 
CGAGAAATAT CCTACCTCAA GAAATTAAAG ATCAAAAAGC AGGACCGGCT GTTCCCTCCA 
GAGAGCAGCG CCCCAGCACC ACCAGCACCT CCCGTCTCGA TCACCTCCGC ACCCACAGCT 
GTGAACTCCT CTGCACCAGC AGACAAACCC CTGTCTAACA TGAAGATCCT GACTCTTGGT 
AAGCTCTCCC AGAACAAGGA CGAAGCAAAG GCCATGATTG AGAAACTCGG AGGCAAGCTG 
ACAGGATCTG CCAACAAGGC CTCCTTGTGT ATCAGCACTA AGAAGGAGGT GGAGAAGATG 
AGTAAGAAGA TGGAGGAAGT GAAAGCAGCC AATGTTCGAG TCGTGTGTGA GGACTTCCTC 
CAGGATGTGT CTGCCTCAGC TAAGAGCCTC CAAGAGCTGC TCTCAGCCCA TAGCTTGTCC 
TCGTGGGGGG CTGAGGTGAA GGTAGAGCCT GGTGAAGTGG TGGTCCCCAA GGGGAAGTCA 
GCTGCACCCT CCAAGAAGAG CAAGGGTGCT GTCAAGGAGG AAGGTGTCAA CAAGTCTGAA 
AAGAGGATGA AACTAACTCT GAAGGGAGGA GCAGCCGTTG ATCCTGACTC TGGTCTGGAA 
CACTCTGCAC ATGTCCTGGA GAAAGGCGGG AAGGTGTTCA GTGCCACGCT TGGCCTGGTG 
GACATTGTGA AAGGGACTAA CTCCTATTAC AAACTGCAAC TTCTGGAGTC CGACAAGGAG 
AGCAGGTATT GGATCTTCCG GTCCTGGGGC CGAGTGGGCA CAGTTATCGG CAGTAACAAG 
CTTGAGCAGA TGCCGTCCAA AGAGGATGCT GTTGAACACT TCATGAAGTT ATACGAAGAG 
AAGACTGGAA ATGCCTGGCA CTCGAAAAAC TTCACAAAGT ATCCCAAGAA GTTCTACCCT 
CTGGAGATTG ACTATGGCCA GGACGAAGAG GCAGTAAAGA AGCTGGCGGT GAAGCCTGGC 
ACTAAGTCGA AGCTGCCGAA GCCGGTGCAG GAGCTCGTCG GGATGATCTT CGACGTGGAG 
AGCATGAAGA AGGCCTTGGT GGAGTACGAG ATTGACCTTC AGAAGATGCC CTTGGGGAAA 
CTGAGCAGAA GGCAGATCCA GGCCGCCTAC TCTATCCTCA GTGAGGTCCA GCAGGCAGTG 
TCCCAAGGCA GCAGTGAATC TCAGATCCTG GATCTCTCCA ATCGCTTCTA CACCCTCATC 
CCCCATGACT TTGGAATGAA GAAGCCCCCA CTTCTGAACA ACACAGACAG TGTGCAGGCC 
AAGGTGGAGA TGCTGGACAA CCTCCTGGAC ATCGAGGTTG CCTATAGTCT TCTCAGGGGT 
GGGTCTGATG ACAGCAGTAA GGACCCCATC GATGTCAACT ATGAGAAGCT CAAAACTGAC 
ATTAAGGTGG TTGACAGAGA TTCTGAAGAG GCTGAGGTCA TCAGGAAGTA TGTGAAGAAC 
ACTCACGCGA CCACGCACAA TGCCTATGAC CTGGAAGTGA TAGACATCTT TAAGATAGAG 
CGAGAGGGAG AGAGCCAACG CTACAAGCCC TTCAGGCAGC TTCACAACCG GAGACTGCTG 
TGGCACGGGT CCAGGACCAC CAACTTCGCA GGCATCCTGT CACAGGGTCT GCGGATAGCC 
CCACCTGAAG CACCTGTGAC AGGCTACATG TTTGGGAAAG GAATCTACTT TGCTGATATG 
GTGTCCAAAA GTGCGAACTA CTGCCACACG TCTCAGGGAG ACCCGATTGG CTTAATACTG 
TTGGGAGAAG TTGCCCTTGG AAACATGTAC GAACTCAAGC ATGCTTCTCA CATCAGCAAG 
TTACCCAAGG GCAAGCACAG TGTCAAAGGT TTGGGCAAAA CCGCCCCTGA CCCTTCGGCC 
AGCATCACCC TGGATGGTGT AGAGGTTCCG CTGGGAACAG GGATTCCGTC TGGTGTTAAT 
GACACCTGCC TGCTGTATAA CGAGTACATT GTCTACGACA TTGCTCAGGT GAATCTGAAG 
TACCTACTGA AACTGAAGTT CAATTTCAAG ACCTCCTTGT GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037195.1
CDS	63..3107
Translation	MAEATERLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRQPDTEVDGFSELRWDDQQKVKKTAEAGGVAGKGQHGGGGKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQMRLSKKMLDPEKPQLGMIDRWYHPTCFVKNRDELGFRPEYSASQLKGFSLLSAEDKEALKKQLPAVKSEGKRKCDEVDGIDEVAKKKSKKGKDKESSKLEKALKAQNELVWNIKDELKKACSTNDLKELLIFNQQQVPSGESAILDRVADGMAFGALLPCKECSGQLVFKSDAYYCTGDVTAWTKCMVKTQNPSRKEWVTPKEFREISYLKKLKIKKQDRLFPPESSAPAPPAPPVSITSAPTAVNSSAPADKPLSNMKILTLGKLSQNKDEAKAMIEKLGGKLTGSANKASLCISTKKEVEKMSKKMEEVKAANVRVVCEDFLQDVSASAKSLQELLSAHSLSSWGAEVKVEPGEVVVPKGKSAAPSKKSKGAVKEEGVNKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLESDKESRYWIFRSWGRVGTVIGSNKLEQMPSKEDAVEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLAVKPGTKSKLPKPVQELVGMIFDVESMKKALVEYEIDLQKMPLGKLSRRQIQAAYSILSEVQQAVSQGSSESQILDLSNRFYTLIPHDFGMKKPPLLNNTDSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEVIRKYVKNTHATTHNAYDLEVIDIFKIEREGESQRYKPFRQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTAPDPSASITLDGVEVPLGTGIPSGVNDTCLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW

Target ORF information:

RefSeq Version	NM_013063.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus poly (ADP-ribose) polymerase 1 (Parp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013063.2

ORF Insert Sequence:

ATGGCGGAGG CCACGGAGAG GCTTTACCGA GTGGAGTACG CTAAGAGCGG GCGCGCCTCT 
TGCAAGAAAT GCAGCGAGAG TATCCCCAAG GACTCGCTCC GCATGGCCAT CATGGTGCAG 
TCACCCATGT TCGATGGAAA AGTCCCACAC TGGTATCACT TCTCCTGCTT CTGGAAGGTG 
GGCCACTCCA TCCGGCAGCC TGACACAGAG GTGGACGGGT TCTCTGAGCT GCGGTGGGAT 
GACCAGCAGA AGGTCAAGAA GACCGCAGAG GCTGGAGGCG TGGCAGGCAA AGGCCAGCAT 
GGAGGTGGCG GCAAGGCGGA GAAGACGCTG GGCGACTTTG CGGCAGAGTA TGCCAAGTCC 
AACAGGAGCA CATGCAAGGG CTGCATGGAG AAGATAGAGA AGGGTCAGAT GCGCCTGTCC 
AAGAAGATGC TGGATCCAGA GAAGCCGCAA CTGGGTATGA TTGACCGCTG GTACCATCCA 
ACTTGCTTTG TCAAGAACCG GGACGAGCTG GGCTTCCGGC CTGAGTACAG TGCCAGCCAG 
CTCAAGGGCT TTAGCCTCCT CTCTGCAGAA GACAAAGAAG CTCTGAAGAA GCAGCTCCCG 
GCAGTCAAGA GTGAAGGAAA GAGAAAATGT GACGAGGTGG ATGGAATAGA TGAAGTAGCC 
AAAAAGAAAT CTAAAAAAGG AAAGGACAAG GAGAGTAGTA AACTGGAAAA GGCGCTCAAG 
GCTCAGAACG AGCTGGTCTG GAATATCAAA GATGAGCTGA AGAAAGCCTG CTCCACCAAC 
GACCTGAAGG AGTTGCTCAT CTTCAACCAG CAGCAAGTAC CATCTGGAGA GTCCGCAATC 
CTGGACCGAG TTGCTGATGG CATGGCGTTT GGGGCCCTTC TGCCCTGCAA GGAGTGTTCA 
GGACAGCTGG TTTTTAAGAG CGACGCTTAT TACTGTACTG GGGATGTCAC TGCCTGGACC 
AAGTGCATGG TCAAGACACA GAATCCCAGC CGAAAGGAAT GGGTAACTCC AAAGGAATTC 
CGAGAAATAT CCTACCTCAA GAAATTAAAG ATCAAAAAGC AGGACCGGCT GTTCCCTCCA 
GAGAGCAGCG CCCCAGCACC ACCAGCACCT CCCGTCTCGA TCACCTCCGC ACCCACAGCT 
GTGAACTCCT CTGCACCAGC AGACAAACCC CTGTCTAACA TGAAGATCCT GACTCTTGGT 
AAGCTCTCCC AGAACAAGGA CGAAGCAAAG GCCATGATTG AGAAACTCGG AGGCAAGCTG 
ACAGGATCTG CCAACAAGGC CTCCTTGTGT ATCAGCACTA AGAAGGAGGT GGAGAAGATG 
AGTAAGAAGA TGGAGGAAGT GAAAGCAGCC AATGTTCGAG TCGTGTGTGA GGACTTCCTC 
CAGGATGTGT CTGCCTCAGC TAAGAGCCTC CAAGAGCTGC TCTCAGCCCA TAGCTTGTCC 
TCGTGGGGGG CTGAGGTGAA GGTAGAGCCT GGTGAAGTGG TGGTCCCCAA GGGGAAGTCA 
GCTGCACCCT CCAAGAAGAG CAAGGGTGCT GTCAAGGAGG AAGGTGTCAA CAAGTCTGAA 
AAGAGGATGA AACTAACTCT GAAGGGAGGA GCAGCCGTTG ATCCTGACTC TGGTCTGGAA 
CACTCTGCAC ATGTCCTGGA GAAAGGCGGG AAGGTGTTCA GTGCCACGCT TGGCCTGGTG 
GACATTGTGA AAGGGACTAA CTCCTATTAC AAACTGCAAC TTCTGGAGTC CGACAAGGAG 
AGCAGGTATT GGATCTTCCG GTCCTGGGGC CGAGTGGGCA CAGTTATCGG CAGTAACAAG 
CTTGAGCAGA TGCCGTCCAA AGAGGATGCT GTTGAACACT TCATGAAGTT ATACGAAGAG 
AAGACTGGAA ATGCCTGGCA CTCGAAAAAC TTCACAAAGT ATCCCAAGAA GTTCTACCCT 
CTGGAGATTG ACTATGGCCA GGACGAAGAG GCAGTAAAGA AGCTGGCGGT GAAGCCTGGC 
ACTAAGTCGA AGCTGCCGAA GCCGGTGCAG GAGCTCGTCG GGATGATCTT CGACGTGGAG 
AGCATGAAGA AGGCCTTGGT GGAGTACGAG ATTGACCTTC AGAAGATGCC CTTGGGGAAA 
CTGAGCAGAA GGCAGATCCA GGCCGCCTAC TCTATCCTCA GTGAGGTCCA GCAGGCAGTG 
TCCCAAGGCA GCAGTGAATC TCAGATCCTG GATCTCTCCA ATCGCTTCTA CACCCTCATC 
CCCCATGACT TTGGAATGAA GAAGCCCCCA CTTCTGAACA ACACAGACAG TGTGCAGGCC 
AAGGTGGAGA TGCTGGACAA CCTCCTGGAC ATCGAGGTTG CCTATAGTCT TCTCAGGGGT 
GGGTCTGATG ACAGCAGTAA GGACCCCATC GATGTCAACT ATGAGAAGCT CAAAACTGAC 
ATTAAGGTGG TTGACAGAGA TTCTGAAGAG GCTGAGGTCA TCAGGAAGTA TGTGAAGAAC 
ACTCACGCGA CCACGCACAA TGCCTATGAC CTGGAAGTGA TAGACATCTT TAAGATAGAG 
CGAGAGGGAG AGAGCCAACG CTACAAGCCC TTCAGGCAGC TTCACAACCG GAGACTGCTG 
TGGCACGGGT CCAGGACCAC CAACTTCGCA GGCATCCTGT CACAGGGTCT GCGGATAGCC 
CCACCTGAAG CACCTGTGAC AGGCTACATG TTTGGGAAAG GAATCTACTT TGCTGATATG 
GTGTCCAAAA GTGCGAACTA CTGCCACACG TCTCAGGGAG ACCCGATTGG CTTAATACTG 
TTGGGAGAAG TTGCCCTTGG AAACATGTAC GAACTCAAGC ATGCTTCTCA CATCAGCAAG 
TTACCCAAGG GCAAGCACAG TGTCAAAGGT TTGGGCAAAA CCGCCCCTGA CCCTTCGGCC 
AGCATCACCC TGGATGGTGT AGAGGTTCCG CTGGGAACAG GGATTCCGTC TGGTGTTAAT 
GACACCTGCC TGCTGTATAA CGAGTACATT GTCTACGACA TTGCTCAGGT GAATCTGAAG 
TACCTACTGA AACTGAAGTT CAATTTCAAG ACCTCCTTGT GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy.
Acta pharmacologica Sinica40(5)589-598(2019 May)
Li Q,Li ZM,Sun SY,Wang LP,Wang PX,Guo Z,Yang HW,Ye JT,Lu J,Liu PQ

DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD
Nature communications10(1)1307(2019 03)
Zhang D,Hu X,Li J,Liu J,Baks-Te Bulte L,Wiersma M,Malik NU,van Marion DMS,Tolouee M,Hoogstra-Berends F,Lanters EAH,van Roon AM,de Vries AAF,Pijnappels DA,de Groot NMS,Henning RH,Brundel BJJM

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Nature563(7729)131-136(2018 11)
Liu H,Zhang H,Wu X,Ma D,Wu J,Wang L,Jiang Y,Fei Y,Zhu C,Tan R,Jungblut P,Pei G,Dorhoi A,Yan Q,Zhang F,Zheng R,Liu S,Liang H,Liu Z,Yang H,Chen J,Wang P,Tang T,Peng W,Hu Z,Xu Z,Huang X,Wang J,Li H,Zhou Y,Liu F,Yan D,Kaufmann SHE,Chen C,Mao Z,Ge B

PARP1 promote autophagy in cardiomyocytes via modulating FoxO3a transcription.
Cell death & disease9(11)1047(2018 10)
Wang C,Xu W,Zhang Y,Zhang F,Huang K

Hypochlorite modified albumins promote cell death in the tubule interstitium in rats via mitochondrial damage in obstructive nephropathy and the protective effects of antioxidant peptides.
Free radical research52(5)616-628(2018 May)
Liu ZR,Chen SQ,Zou YW,Wu XY,Li HY,Wang XQ,Shi Y,Niu HX

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Parp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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