Parp1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Parp1
Entrez Gene ID	11545
Full Name	poly (ADP-ribose) polymerase family, member 1
Synonyms	5830444G22Rik,AI893648,ARTD1,Adprp,Adprt1,C80510,PARP,PPOL,parp-1,sPARP-1
General protein information	Preferred Names poly (ADP-ribose) polymerase family, member 1 Names poly [ADP-ribose] polymerase 1 ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1 ADP-ribosyltransferase diphtheria toxin-like 1 ADPRT 1 NAD(+) ADP-ribosyltransferase 1 msPARP poly(ADP-ribose) polymerase poly[ADP-ribose] synthase 1 poly[ADP-ribose] synthetase 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 H4\|1 84.44 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007415.2	NP_031441.2	poly [ADP-ribose] polymerase 1
NM_007415.3	NP_031441.2	poly [ADP-ribose] polymerase 1

Pathways from BioSystems

Homologies

Arabidopsis thaliana (thale cress)	PARP1	NP_850165.1
Oryza sativa (rice)	Os07g0413700	NP_001059453.1
Drosophila melanogaster (fruit fly)	Parp	NP_001104452.1
Homo sapiens (human)	PARP1	NP_001609.2
Pan troglodytes (chimpanzee)	PARP1	XP_003949754.1
Canis lupus familiaris (dog)	PARP1	XP_547506.3
Bos taurus (cattle)	PARP1	NP_777176.1
Macaca mulatta (Rhesus monkey)	PARP1	XP_001090984.1
Gallus gallus (chicken)	PARP1	NP_990594.1
Xenopus tropicalis (tropical clawed frog)	parp1	XP_002941174.2
Danio rerio (zebrafish)	parp1	NP_001038407.1
Caenorhabditis elegans (roundworm)	pme-1	NP_491072.1
Mus musculus (house mouse)	Parp1	NP_031441.2
Rattus norvegicus (Norway rat)	Parp1	NP_037195.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003230	XP_312938.4

Gene Ontology
Bibliography

Related articles in PubMed

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.
Zhang X, Zhang H, Xu C, Li X, Li M, Wu X, Pu W, Zhou B, Wang H, Li D, Ding Q, Ying H, Wang H, Zhang H
Nature communications10(1)4158(2019 09)

PARP-1 inhibition provides protection against elastase-induced emphysema by mitigating the expression of matrix metalloproteinases.
Dharwal V, Sandhir R, Naura AS
Molecular and cellular biochemistry457(1-2)41-49(2019 Jul)

ARTD1 in Myeloid Cells Controls the IL-12/18-IFN-γ Axis in a Model of Sterile Sepsis, Chronic Bacterial Infection, and Cancer.
Kunze FA, Bauer M, Komuczki J, Lanzinger M, Gunasekera K, Hopp AK, Lehmann M, Becher B, Müller A, Hottiger MO
Journal of immunology (Baltimore, Md. : 1950)202(5)1406-1416(2019 03)

DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD
Zhang D, Hu X, Li J, Liu J, Baks-Te Bulte L, Wiersma M, Malik NU, van Marion DMS, Tolouee M, Hoogstra-Berends F, Lanters EAH, van Roon AM, de Vries AAF, Pijnappels DA, de Groot NMS, Henning RH, Brundel BJJM
Nature communications10(1)1307(2019 03)

Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration.
Allocca M, Corrigan JJ, Mazumder A, Fake KR, Samson LD
Science signaling12(568)(2019 02)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Parp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Parp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu20445	NM_007415.3 Latest version!	Mus musculus poly (ADP-ribose) polymerase family, member 1 (Parp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
View Old Accession Versions >>
OMu20445	NM_007415.2	Mus musculus poly (ADP-ribose) polymerase family, member 1 (Parp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Parp1 ( NM_007415.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031441.2 Mus musculus poly (ADP-ribose) polymerase family, member 1 (Parp1), mRNA.

Price & Availability↑

CloneID	OMu20445
Clone ID Related Accession (Same CDS sequence)	NM_007415.2 , NM_007415.3
Accession Version	NM_007415.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3045bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1512403200000
Organism	Mus musculus(house mouse)
Product	poly [ADP-ribose] polymerase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC012041.1. On May 16, 2002 this sequence version replaced NM_007415.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012041.1, AK146677.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGAGG CCTCGGAGAG GCTTTATCGA GTGGAGTACG CGAAGAGCGG GCGCGCCTCT 
TGCAAGAAAT GCAGCGAGAG TATTCCCAAG GACTCCCTCC GCATGGCCAT CATGGTGCAG 
TCACCCATGT TCGATGGGAA AGTCCCACAC TGGTACCACT TCTCCTGCTT CTGGAAGGTG 
GGCCACTCCA TCCGGCAGCC TGATGTTGAG GTGGATGGCT TCTCTGAGCT GCGCTGGGAT 
GATCAGCAGA AGGTCAAGAA GACGGCCGAG GCTGGAGGCG TGGCAGGCAA AGGCCAGGAT 
GGAAGTGGCG GCAAGGCGGA GAAGACATTG GGTGACTTTT TAGCGGAGTA CGCCAAGTCC 
AACAGGAGCA TGTGCAAGGG CTGCCTGGAG AAGATAGAGA AGGGCCAGAT GCGCCTGTCC 
AAGAAGATGG TGGATCCAGA GAAGCCACAG CTGGGTATGA TTGACCGCTG GTACCATCCA 
ACTTGCTTTG TCAAGAAGCG GGACGAGCTG GGCTTCCGGC CTGAGTACAG TGCCAGTCAG 
CTCAAGGGCT TTAGCCTCCT CTCTGCAGAA GACAAAGAAG CTCTGAAGAA GCAGCTCCCG 
GCCATCAAGA ATGAAGGAAA GAGAAAAGGT GACGAGGTGG ATGGAACAGA TGAAGTGGCC 
AAAAAGAAAT CTAAGAAAGG GAAGGACAAG GATAGTAGTA AGCTGGAGAA GGCCCTCAAG 
GCTCAGAATG AGCTGATCTG GAATATCAAA GACGAGCTGA AGAAAGCGTG TTCCACCAAC 
GACCTGAAGG AGCTGCTCAT CTTCAACCAG CAGCAGGTGC CGTCAGGAGA GTCAGCGATC 
TTGGACAGAG TTGCTGACGG CATGGCGTTT GGGGCCCTTC TGCCCTGCAA GGAGTGTTCA 
GGCCAGCTGG TCTTTAAGAG CGACGCTTAT TACTGTACTG GGGATGTCAC TGCCTGGACC 
AAGTGCATGG TCAAGACACA GAATCCTAGC CGAAAGGAAT GGGTAACTCC AAAGGAATTC 
CGAGAAATAT CCTACCTCAA GAAGTTAAAG GTCAAAAAAC AGGACCGAAT ATTCCCTCCA 
GAAAGCAGCG CCCCAGCACC ACTGGCACTG CCCCTCTCTG TCACCTCAGC ACCCACAGCT 
GTGAACTCCT CTGCTCCAGC AGACAAGCCC CTGTCTAACA TGAAGATCCT GACTCTTGGG 
AAGCTCTCCC AGAACAAGGA CGAAGCAAAA GCTGTGATTG AGAAACTCGG AGGCAAGTTG 
ACAGGATCTG CCAACAAGGC CTCCTTGTGT ATCAGCACTA AAAAGGAGGT GGAGAAGATG 
AGTAAGAAGA TGGAGGAAGT GAAAGCGGCC AACGTTCGAG TTGTGTGTGA GGACTTCCTC 
CAGGACGTGT CTGCCTCCAC TAAAAGCCTC CAAGAGCTGC TCTCGGCCCA CAGCTTGTCC 
TCGTGGGGGG CTGAGGTGAA GGCAGAGCCT GGTGAAGTGG TGGCCCCCAA GGGGAAGTCA 
GCTGCACCCT CCAAGAAGAG CAAGGGTGCT GTCAAGGAGG AAGGTGTCAA CAAATCTGAA 
AAGAGGATGA AATTAACTCT GAAGGGAGGA GCAGCCGTTG ATCCTGACTC TGGTCTGGAA 
CACTCTGCAC ACGTCCTGGA GAAAGGTGGG AAGGTGTTCA GCGCCACACT TGGCCTGGTG 
GACATTGTGA AAGGGACGAA CTCCTATTAC AAACTGCAGC TTCTGGAGGA CGACAAGGAG 
AGCAGGTACT GGATCTTCCG GTCCTGGGGC CGGGTGGGCA CAGTTATCGG CAGTAACAAA 
CTTGAGCAGA TGCCCTCCAA AGAGGACGCT GTTGAGCACT TCATGAAGCT GTATGAAGAG 
AAGACTGGGA ATGCCTGGCA CTCGAAAAAC TTCACAAAGT ATCCCAAGAA GTTCTACCCT 
CTGGAGATTG ACTATGGCCA GGACGAAGAG GCAGTAAAGA AGCTGACGGT GAAGCCTGGC 
ACCAAGTCGA AGCTGCCGAA GCCAGTGCAG GAGCTCGTGG GGATGATCTT CGACGTGGAG 
AGCATGAAAA AGGCCTTGGT GGAGTACGAG ATTGACCTCC AGAAGATGCC CTTGGGGAAG 
CTGAGCAGAA GGCAGATCCA GGCCGCCTAC TCTATCCTCA GCGAGGTCCA GCAGGCAGTG 
TCTCAAGGCA GCAGTGAATC CCAGATCCTA GATCTCTCCA ATCGCTTCTA CACTCTGATC 
CCCCATGACT TTGGAATGAA GAAGCCCCCA CTCCTGAACA ACGCAGACAG CGTGCAGGCC 
AAGGTGGAGA TGCTAGACAA CCTCCTGGAC ATCGAGGTGG CCTATAGTCT TCTCAGGGGT 
GGCTCTGACG ACAGCAGCAA GGATCCCATC GACGTCAACT ACGAGAAACT CAAAACTGAC 
ATTAAGGTGG TTGACAGAGA TTCTGAAGAG GCCGAGGTCA TCAGGAAGTA CGTGAAGAAC 
ACTCATGCTA CCACGCACAA CGCCTATGAC CTGGAAGTGA TCGATATCTT CAAGATAGAG 
CGCGAGGGGG AGAGCCAGCG CTACAAGCCC TTCAGGCAGC TTCACAACCG GAGGCTGCTG 
TGGCACGGCT CCAGGACCAC CAACTTTGCT GGCATCCTGT CGCAGGGTCT GCGGATAGCC 
CCACCTGAAG CGCCTGTGAC AGGCTACATG TTTGGGAAAG GGATCTACTT TGCCGACATG 
GTGTCCAAAA GTGCAAACTA CTGCCACACA TCTCAGGGAG ACCCGATTGG CTTAATACTG 
CTGGGAGAGG TTGCCCTTGG AAACATGTAT GAACTCAAGC ATGCTTCACA TATCAGCAAG 
TTACCCAAGG GCAAGCACAG TGTCAAAGGT TTGGGAAAAA CCACCCCTGA CCCTTCGGCC 
AGCATCACCC TGGAGGGTGT AGAGGTTCCA CTGGGAACAG GGATCCCATC TGGTGTCAAC 
GACACCTGCC TGCTGTATAA TGAGTACATT GTCTACGACA TTGCTCAGGT GAATCTCAAA 
TACCTGCTGA AACTCAAGTT CAATTTTAAG ACATCCCTGT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031441.2
CDS	60..3104
Translation	MAEASERLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRQPDVEVDGFSELRWDDQQKVKKTAEAGGVAGKGQDGSGGKAEKTLGDFLAEYAKSNRSMCKGCLEKIEKGQMRLSKKMVDPEKPQLGMIDRWYHPTCFVKKRDELGFRPEYSASQLKGFSLLSAEDKEALKKQLPAIKNEGKRKGDEVDGTDEVAKKKSKKGKDKDSSKLEKALKAQNELIWNIKDELKKACSTNDLKELLIFNQQQVPSGESAILDRVADGMAFGALLPCKECSGQLVFKSDAYYCTGDVTAWTKCMVKTQNPSRKEWVTPKEFREISYLKKLKVKKQDRIFPPESSAPAPLALPLSVTSAPTAVNSSAPADKPLSNMKILTLGKLSQNKDEAKAVIEKLGGKLTGSANKASLCISTKKEVEKMSKKMEEVKAANVRVVCEDFLQDVSASTKSLQELLSAHSLSSWGAEVKAEPGEVVAPKGKSAAPSKKSKGAVKEEGVNKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKESRYWIFRSWGRVGTVIGSNKLEQMPSKEDAVEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVKPGTKSKLPKPVQELVGMIFDVESMKKALVEYEIDLQKMPLGKLSRRQIQAAYSILSEVQQAVSQGSSESQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEVIRKYVKNTHATTHNAYDLEVIDIFKIEREGESQRYKPFRQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSASITLEGVEVPLGTGIPSGVNDTCLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW

Target ORF information:

RefSeq Version	NM_007415.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus poly (ADP-ribose) polymerase family, member 1 (Parp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007415.2

ORF Insert Sequence:

ATGGCGGAGG CCTCGGAGAG GCTTTATCGA GTGGAGTACG CGAAGAGCGG GCGCGCCTCT 
TGCAAGAAAT GCAGCGAGAG TATTCCCAAG GACTCCCTCC GCATGGCCAT CATGGTGCAG 
TCACCCATGT TCGATGGGAA AGTCCCACAC TGGTACCACT TCTCCTGCTT CTGGAAGGTG 
GGCCACTCCA TCCGGCAGCC TGATGTTGAG GTGGATGGCT TCTCTGAGCT GCGCTGGGAT 
GATCAGCAGA AGGTCAAGAA GACGGCCGAG GCTGGAGGCG TGGCAGGCAA AGGCCAGGAT 
GGAAGTGGCG GCAAGGCGGA GAAGACATTG GGTGACTTTT TAGCGGAGTA CGCCAAGTCC 
AACAGGAGCA TGTGCAAGGG CTGCCTGGAG AAGATAGAGA AGGGCCAGAT GCGCCTGTCC 
AAGAAGATGG TGGATCCAGA GAAGCCACAG CTGGGTATGA TTGACCGCTG GTACCATCCA 
ACTTGCTTTG TCAAGAAGCG GGACGAGCTG GGCTTCCGGC CTGAGTACAG TGCCAGTCAG 
CTCAAGGGCT TTAGCCTCCT CTCTGCAGAA GACAAAGAAG CTCTGAAGAA GCAGCTCCCG 
GCCATCAAGA ATGAAGGAAA GAGAAAAGGT GACGAGGTGG ATGGAACAGA TGAAGTGGCC 
AAAAAGAAAT CTAAGAAAGG GAAGGACAAG GATAGTAGTA AGCTGGAGAA GGCCCTCAAG 
GCTCAGAATG AGCTGATCTG GAATATCAAA GACGAGCTGA AGAAAGCGTG TTCCACCAAC 
GACCTGAAGG AGCTGCTCAT CTTCAACCAG CAGCAGGTGC CGTCAGGAGA GTCAGCGATC 
TTGGACAGAG TTGCTGACGG CATGGCGTTT GGGGCCCTTC TGCCCTGCAA GGAGTGTTCA 
GGCCAGCTGG TCTTTAAGAG CGACGCTTAT TACTGTACTG GGGATGTCAC TGCCTGGACC 
AAGTGCATGG TCAAGACACA GAATCCTAGC CGAAAGGAAT GGGTAACTCC AAAGGAATTC 
CGAGAAATAT CCTACCTCAA GAAGTTAAAG GTCAAAAAAC AGGACCGAAT ATTCCCTCCA 
GAAAGCAGCG CCCCAGCACC ACTGGCACTG CCCCTCTCTG TCACCTCAGC ACCCACAGCT 
GTGAACTCCT CTGCTCCAGC AGACAAGCCC CTGTCTAACA TGAAGATCCT GACTCTTGGG 
AAGCTCTCCC AGAACAAGGA CGAAGCAAAA GCTGTGATTG AGAAACTCGG AGGCAAGTTG 
ACAGGATCTG CCAACAAGGC CTCCTTGTGT ATCAGCACTA AAAAGGAGGT GGAGAAGATG 
AGTAAGAAGA TGGAGGAAGT GAAAGCGGCC AACGTTCGAG TTGTGTGTGA GGACTTCCTC 
CAGGACGTGT CTGCCTCCAC TAAAAGCCTC CAAGAGCTGC TCTCGGCCCA CAGCTTGTCC 
TCGTGGGGGG CTGAGGTGAA GGCAGAGCCT GGTGAAGTGG TGGCCCCCAA GGGGAAGTCA 
GCTGCACCCT CCAAGAAGAG CAAGGGTGCT GTCAAGGAGG AAGGTGTCAA CAAATCTGAA 
AAGAGGATGA AATTAACTCT GAAGGGAGGA GCAGCCGTTG ATCCTGACTC TGGTCTGGAA 
CACTCTGCAC ACGTCCTGGA GAAAGGTGGG AAGGTGTTCA GCGCCACACT TGGCCTGGTG 
GACATTGTGA AAGGGACGAA CTCCTATTAC AAACTGCAGC TTCTGGAGGA CGACAAGGAG 
AGCAGGTACT GGATCTTCCG GTCCTGGGGC CGGGTGGGCA CAGTTATCGG CAGTAACAAA 
CTTGAGCAGA TGCCCTCCAA AGAGGACGCT GTTGAGCACT TCATGAAGCT GTATGAAGAG 
AAGACTGGGA ATGCCTGGCA CTCGAAAAAC TTCACAAAGT ATCCCAAGAA GTTCTACCCT 
CTGGAGATTG ACTATGGCCA GGACGAAGAG GCAGTAAAGA AGCTGACGGT GAAGCCTGGC 
ACCAAGTCGA AGCTGCCGAA GCCAGTGCAG GAGCTCGTGG GGATGATCTT CGACGTGGAG 
AGCATGAAAA AGGCCTTGGT GGAGTACGAG ATTGACCTCC AGAAGATGCC CTTGGGGAAG 
CTGAGCAGAA GGCAGATCCA GGCCGCCTAC TCTATCCTCA GCGAGGTCCA GCAGGCAGTG 
TCTCAAGGCA GCAGTGAATC CCAGATCCTA GATCTCTCCA ATCGCTTCTA CACTCTGATC 
CCCCATGACT TTGGAATGAA GAAGCCCCCA CTCCTGAACA ACGCAGACAG CGTGCAGGCC 
AAGGTGGAGA TGCTAGACAA CCTCCTGGAC ATCGAGGTGG CCTATAGTCT TCTCAGGGGT 
GGCTCTGACG ACAGCAGCAA GGATCCCATC GACGTCAACT ACGAGAAACT CAAAACTGAC 
ATTAAGGTGG TTGACAGAGA TTCTGAAGAG GCCGAGGTCA TCAGGAAGTA CGTGAAGAAC 
ACTCATGCTA CCACGCACAA CGCCTATGAC CTGGAAGTGA TCGATATCTT CAAGATAGAG 
CGCGAGGGGG AGAGCCAGCG CTACAAGCCC TTCAGGCAGC TTCACAACCG GAGGCTGCTG 
TGGCACGGCT CCAGGACCAC CAACTTTGCT GGCATCCTGT CGCAGGGTCT GCGGATAGCC 
CCACCTGAAG CGCCTGTGAC AGGCTACATG TTTGGGAAAG GGATCTACTT TGCCGACATG 
GTGTCCAAAA GTGCAAACTA CTGCCACACA TCTCAGGGAG ACCCGATTGG CTTAATACTG 
CTGGGAGAGG TTGCCCTTGG AAACATGTAT GAACTCAAGC ATGCTTCACA TATCAGCAAG 
TTACCCAAGG GCAAGCACAG TGTCAAAGGT TTGGGAAAAA CCACCCCTGA CCCTTCGGCC 
AGCATCACCC TGGAGGGTGT AGAGGTTCCA CTGGGAACAG GGATCCCATC TGGTGTCAAC 
GACACCTGCC TGCTGTATAA TGAGTACATT GTCTACGACA TTGCTCAGGT GAATCTCAAA 
TACCTGCTGA AACTCAAGTT CAATTTTAAG ACATCCCTGT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Parp1 ( NM_007415.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031441.2 Mus musculus poly (ADP-ribose) polymerase family, member 1 (Parp1), mRNA.

Price & Availability↑

CloneID	OMu20445
Clone ID Related Accession (Same CDS sequence)	NM_007415.2 , NM_007415.3
Accession Version	NM_007415.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3045bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1576425600000
Organism	Mus musculus(house mouse)
Product	poly [ADP-ribose] polymerase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ153239.1, AK159433.1 and AC121810.3. On Feb 13, 2018 this sequence version replaced NM_007415.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK088679.1, AK166104.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGAGG CCTCGGAGAG GCTTTATCGA GTGGAGTACG CGAAGAGCGG GCGCGCCTCT 
TGCAAGAAAT GCAGCGAGAG TATTCCCAAG GACTCCCTCC GCATGGCCAT CATGGTGCAG 
TCACCCATGT TCGATGGGAA AGTCCCACAC TGGTACCACT TCTCCTGCTT CTGGAAGGTG 
GGCCACTCCA TCCGGCAGCC TGATGTTGAG GTGGATGGCT TCTCTGAGCT GCGCTGGGAT 
GATCAGCAGA AGGTCAAGAA GACGGCCGAG GCTGGAGGCG TGGCAGGCAA AGGCCAGGAT 
GGAAGTGGCG GCAAGGCGGA GAAGACATTG GGTGACTTTT TAGCGGAGTA CGCCAAGTCC 
AACAGGAGCA TGTGCAAGGG CTGCCTGGAG AAGATAGAGA AGGGCCAGAT GCGCCTGTCC 
AAGAAGATGG TGGATCCAGA GAAGCCACAG CTGGGTATGA TTGACCGCTG GTACCATCCA 
ACTTGCTTTG TCAAGAAGCG GGACGAGCTG GGCTTCCGGC CTGAGTACAG TGCCAGTCAG 
CTCAAGGGCT TTAGCCTCCT CTCTGCAGAA GACAAAGAAG CTCTGAAGAA GCAGCTCCCG 
GCCATCAAGA ATGAAGGAAA GAGAAAAGGT GACGAGGTGG ATGGAACAGA TGAAGTGGCC 
AAAAAGAAAT CTAAGAAAGG GAAGGACAAG GATAGTAGTA AGCTGGAGAA GGCCCTCAAG 
GCTCAGAATG AGCTGATCTG GAATATCAAA GACGAGCTGA AGAAAGCGTG TTCCACCAAC 
GACCTGAAGG AGCTGCTCAT CTTCAACCAG CAGCAGGTGC CGTCAGGAGA GTCAGCGATC 
TTGGACAGAG TTGCTGACGG CATGGCGTTT GGGGCCCTTC TGCCCTGCAA GGAGTGTTCA 
GGCCAGCTGG TCTTTAAGAG CGACGCTTAT TACTGTACTG GGGATGTCAC TGCCTGGACC 
AAGTGCATGG TCAAGACACA GAATCCTAGC CGAAAGGAAT GGGTAACTCC AAAGGAATTC 
CGAGAAATAT CCTACCTCAA GAAGTTAAAG GTCAAAAAAC AGGACCGAAT ATTCCCTCCA 
GAAAGCAGCG CCCCAGCACC ACTGGCACTG CCCCTCTCTG TCACCTCAGC ACCCACAGCT 
GTGAACTCCT CTGCTCCAGC AGACAAGCCC CTGTCTAACA TGAAGATCCT GACTCTTGGG 
AAGCTCTCCC AGAACAAGGA CGAAGCAAAA GCTGTGATTG AGAAACTCGG AGGCAAGTTG 
ACAGGATCTG CCAACAAGGC CTCCTTGTGT ATCAGCACTA AAAAGGAGGT GGAGAAGATG 
AGTAAGAAGA TGGAGGAAGT GAAAGCGGCC AACGTTCGAG TTGTGTGTGA GGACTTCCTC 
CAGGACGTGT CTGCCTCCAC TAAAAGCCTC CAAGAGCTGC TCTCGGCCCA CAGCTTGTCC 
TCGTGGGGGG CTGAGGTGAA GGCAGAGCCT GGTGAAGTGG TGGCCCCCAA GGGGAAGTCA 
GCTGCACCCT CCAAGAAGAG CAAGGGTGCT GTCAAGGAGG AAGGTGTCAA CAAATCTGAA 
AAGAGGATGA AATTAACTCT GAAGGGAGGA GCAGCCGTTG ATCCTGACTC TGGTCTGGAA 
CACTCTGCAC ACGTCCTGGA GAAAGGTGGG AAGGTGTTCA GCGCCACACT TGGCCTGGTG 
GACATTGTGA AAGGGACGAA CTCCTATTAC AAACTGCAGC TTCTGGAGGA CGACAAGGAG 
AGCAGGTACT GGATCTTCCG GTCCTGGGGC CGGGTGGGCA CAGTTATCGG CAGTAACAAA 
CTTGAGCAGA TGCCCTCCAA AGAGGACGCT GTTGAGCACT TCATGAAGCT GTATGAAGAG 
AAGACTGGGA ATGCCTGGCA CTCGAAAAAC TTCACAAAGT ATCCCAAGAA GTTCTACCCT 
CTGGAGATTG ACTATGGCCA GGACGAAGAG GCAGTAAAGA AGCTGACGGT GAAGCCTGGC 
ACCAAGTCGA AGCTGCCGAA GCCAGTGCAG GAGCTCGTGG GGATGATCTT CGACGTGGAG 
AGCATGAAAA AGGCCTTGGT GGAGTACGAG ATTGACCTCC AGAAGATGCC CTTGGGGAAG 
CTGAGCAGAA GGCAGATCCA GGCCGCCTAC TCTATCCTCA GCGAGGTCCA GCAGGCAGTG 
TCTCAAGGCA GCAGTGAATC CCAGATCCTA GATCTCTCCA ATCGCTTCTA CACTCTGATC 
CCCCATGACT TTGGAATGAA GAAGCCCCCA CTCCTGAACA ACGCAGACAG CGTGCAGGCC 
AAGGTGGAGA TGCTAGACAA CCTCCTGGAC ATCGAGGTGG CCTATAGTCT TCTCAGGGGT 
GGCTCTGACG ACAGCAGCAA GGATCCCATC GACGTCAACT ACGAGAAACT CAAAACTGAC 
ATTAAGGTGG TTGACAGAGA TTCTGAAGAG GCCGAGGTCA TCAGGAAGTA CGTGAAGAAC 
ACTCATGCTA CCACGCACAA CGCCTATGAC CTGGAAGTGA TCGATATCTT CAAGATAGAG 
CGCGAGGGGG AGAGCCAGCG CTACAAGCCC TTCAGGCAGC TTCACAACCG GAGGCTGCTG 
TGGCACGGCT CCAGGACCAC CAACTTTGCT GGCATCCTGT CGCAGGGTCT GCGGATAGCC 
CCACCTGAAG CGCCTGTGAC AGGCTACATG TTTGGGAAAG GGATCTACTT TGCCGACATG 
GTGTCCAAAA GTGCAAACTA CTGCCACACA TCTCAGGGAG ACCCGATTGG CTTAATACTG 
CTGGGAGAGG TTGCCCTTGG AAACATGTAT GAACTCAAGC ATGCTTCACA TATCAGCAAG 
TTACCCAAGG GCAAGCACAG TGTCAAAGGT TTGGGAAAAA CCACCCCTGA CCCTTCGGCC 
AGCATCACCC TGGAGGGTGT AGAGGTTCCA CTGGGAACAG GGATCCCATC TGGTGTCAAC 
GACACCTGCC TGCTGTATAA TGAGTACATT GTCTACGACA TTGCTCAGGT GAATCTCAAA 
TACCTGCTGA AACTCAAGTT CAATTTTAAG ACATCCCTGT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031441.2
CDS	144..3188
Translation	MAEASERLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRQPDVEVDGFSELRWDDQQKVKKTAEAGGVAGKGQDGSGGKAEKTLGDFLAEYAKSNRSMCKGCLEKIEKGQMRLSKKMVDPEKPQLGMIDRWYHPTCFVKKRDELGFRPEYSASQLKGFSLLSAEDKEALKKQLPAIKNEGKRKGDEVDGTDEVAKKKSKKGKDKDSSKLEKALKAQNELIWNIKDELKKACSTNDLKELLIFNQQQVPSGESAILDRVADGMAFGALLPCKECSGQLVFKSDAYYCTGDVTAWTKCMVKTQNPSRKEWVTPKEFREISYLKKLKVKKQDRIFPPESSAPAPLALPLSVTSAPTAVNSSAPADKPLSNMKILTLGKLSQNKDEAKAVIEKLGGKLTGSANKASLCISTKKEVEKMSKKMEEVKAANVRVVCEDFLQDVSASTKSLQELLSAHSLSSWGAEVKAEPGEVVAPKGKSAAPSKKSKGAVKEEGVNKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKESRYWIFRSWGRVGTVIGSNKLEQMPSKEDAVEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVKPGTKSKLPKPVQELVGMIFDVESMKKALVEYEIDLQKMPLGKLSRRQIQAAYSILSEVQQAVSQGSSESQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEVIRKYVKNTHATTHNAYDLEVIDIFKIEREGESQRYKPFRQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSASITLEGVEVPLGTGIPSGVNDTCLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW

Target ORF information:

RefSeq Version	NM_007415.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus poly (ADP-ribose) polymerase family, member 1 (Parp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007415.3

ORF Insert Sequence:

ATGGCGGAGG CCTCGGAGAG GCTTTATCGA GTGGAGTACG CGAAGAGCGG GCGCGCCTCT 
TGCAAGAAAT GCAGCGAGAG TATTCCCAAG GACTCCCTCC GCATGGCCAT CATGGTGCAG 
TCACCCATGT TCGATGGGAA AGTCCCACAC TGGTACCACT TCTCCTGCTT CTGGAAGGTG 
GGCCACTCCA TCCGGCAGCC TGATGTTGAG GTGGATGGCT TCTCTGAGCT GCGCTGGGAT 
GATCAGCAGA AGGTCAAGAA GACGGCCGAG GCTGGAGGCG TGGCAGGCAA AGGCCAGGAT 
GGAAGTGGCG GCAAGGCGGA GAAGACATTG GGTGACTTTT TAGCGGAGTA CGCCAAGTCC 
AACAGGAGCA TGTGCAAGGG CTGCCTGGAG AAGATAGAGA AGGGCCAGAT GCGCCTGTCC 
AAGAAGATGG TGGATCCAGA GAAGCCACAG CTGGGTATGA TTGACCGCTG GTACCATCCA 
ACTTGCTTTG TCAAGAAGCG GGACGAGCTG GGCTTCCGGC CTGAGTACAG TGCCAGTCAG 
CTCAAGGGCT TTAGCCTCCT CTCTGCAGAA GACAAAGAAG CTCTGAAGAA GCAGCTCCCG 
GCCATCAAGA ATGAAGGAAA GAGAAAAGGT GACGAGGTGG ATGGAACAGA TGAAGTGGCC 
AAAAAGAAAT CTAAGAAAGG GAAGGACAAG GATAGTAGTA AGCTGGAGAA GGCCCTCAAG 
GCTCAGAATG AGCTGATCTG GAATATCAAA GACGAGCTGA AGAAAGCGTG TTCCACCAAC 
GACCTGAAGG AGCTGCTCAT CTTCAACCAG CAGCAGGTGC CGTCAGGAGA GTCAGCGATC 
TTGGACAGAG TTGCTGACGG CATGGCGTTT GGGGCCCTTC TGCCCTGCAA GGAGTGTTCA 
GGCCAGCTGG TCTTTAAGAG CGACGCTTAT TACTGTACTG GGGATGTCAC TGCCTGGACC 
AAGTGCATGG TCAAGACACA GAATCCTAGC CGAAAGGAAT GGGTAACTCC AAAGGAATTC 
CGAGAAATAT CCTACCTCAA GAAGTTAAAG GTCAAAAAAC AGGACCGAAT ATTCCCTCCA 
GAAAGCAGCG CCCCAGCACC ACTGGCACTG CCCCTCTCTG TCACCTCAGC ACCCACAGCT 
GTGAACTCCT CTGCTCCAGC AGACAAGCCC CTGTCTAACA TGAAGATCCT GACTCTTGGG 
AAGCTCTCCC AGAACAAGGA CGAAGCAAAA GCTGTGATTG AGAAACTCGG AGGCAAGTTG 
ACAGGATCTG CCAACAAGGC CTCCTTGTGT ATCAGCACTA AAAAGGAGGT GGAGAAGATG 
AGTAAGAAGA TGGAGGAAGT GAAAGCGGCC AACGTTCGAG TTGTGTGTGA GGACTTCCTC 
CAGGACGTGT CTGCCTCCAC TAAAAGCCTC CAAGAGCTGC TCTCGGCCCA CAGCTTGTCC 
TCGTGGGGGG CTGAGGTGAA GGCAGAGCCT GGTGAAGTGG TGGCCCCCAA GGGGAAGTCA 
GCTGCACCCT CCAAGAAGAG CAAGGGTGCT GTCAAGGAGG AAGGTGTCAA CAAATCTGAA 
AAGAGGATGA AATTAACTCT GAAGGGAGGA GCAGCCGTTG ATCCTGACTC TGGTCTGGAA 
CACTCTGCAC ACGTCCTGGA GAAAGGTGGG AAGGTGTTCA GCGCCACACT TGGCCTGGTG 
GACATTGTGA AAGGGACGAA CTCCTATTAC AAACTGCAGC TTCTGGAGGA CGACAAGGAG 
AGCAGGTACT GGATCTTCCG GTCCTGGGGC CGGGTGGGCA CAGTTATCGG CAGTAACAAA 
CTTGAGCAGA TGCCCTCCAA AGAGGACGCT GTTGAGCACT TCATGAAGCT GTATGAAGAG 
AAGACTGGGA ATGCCTGGCA CTCGAAAAAC TTCACAAAGT ATCCCAAGAA GTTCTACCCT 
CTGGAGATTG ACTATGGCCA GGACGAAGAG GCAGTAAAGA AGCTGACGGT GAAGCCTGGC 
ACCAAGTCGA AGCTGCCGAA GCCAGTGCAG GAGCTCGTGG GGATGATCTT CGACGTGGAG 
AGCATGAAAA AGGCCTTGGT GGAGTACGAG ATTGACCTCC AGAAGATGCC CTTGGGGAAG 
CTGAGCAGAA GGCAGATCCA GGCCGCCTAC TCTATCCTCA GCGAGGTCCA GCAGGCAGTG 
TCTCAAGGCA GCAGTGAATC CCAGATCCTA GATCTCTCCA ATCGCTTCTA CACTCTGATC 
CCCCATGACT TTGGAATGAA GAAGCCCCCA CTCCTGAACA ACGCAGACAG CGTGCAGGCC 
AAGGTGGAGA TGCTAGACAA CCTCCTGGAC ATCGAGGTGG CCTATAGTCT TCTCAGGGGT 
GGCTCTGACG ACAGCAGCAA GGATCCCATC GACGTCAACT ACGAGAAACT CAAAACTGAC 
ATTAAGGTGG TTGACAGAGA TTCTGAAGAG GCCGAGGTCA TCAGGAAGTA CGTGAAGAAC 
ACTCATGCTA CCACGCACAA CGCCTATGAC CTGGAAGTGA TCGATATCTT CAAGATAGAG 
CGCGAGGGGG AGAGCCAGCG CTACAAGCCC TTCAGGCAGC TTCACAACCG GAGGCTGCTG 
TGGCACGGCT CCAGGACCAC CAACTTTGCT GGCATCCTGT CGCAGGGTCT GCGGATAGCC 
CCACCTGAAG CGCCTGTGAC AGGCTACATG TTTGGGAAAG GGATCTACTT TGCCGACATG 
GTGTCCAAAA GTGCAAACTA CTGCCACACA TCTCAGGGAG ACCCGATTGG CTTAATACTG 
CTGGGAGAGG TTGCCCTTGG AAACATGTAT GAACTCAAGC ATGCTTCACA TATCAGCAAG 
TTACCCAAGG GCAAGCACAG TGTCAAAGGT TTGGGAAAAA CCACCCCTGA CCCTTCGGCC 
AGCATCACCC TGGAGGGTGT AGAGGTTCCA CTGGGAACAG GGATCCCATC TGGTGTCAAC 
GACACCTGCC TGCTGTATAA TGAGTACATT GTCTACGACA TTGCTCAGGT GAATCTCAAA 
TACCTGCTGA AACTCAAGTT CAATTTTAAG ACATCCCTGT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.
Nature communications10(1)4158(2019 09)
Zhang X,Zhang H,Xu C,Li X,Li M,Wu X,Pu W,Zhou B,Wang H,Li D,Ding Q,Ying H,Wang H,Zhang H

PARP-1 inhibition provides protection against elastase-induced emphysema by mitigating the expression of matrix metalloproteinases.
Molecular and cellular biochemistry457(1-2)41-49(2019 Jul)
Dharwal V,Sandhir R,Naura AS

ARTD1 in Myeloid Cells Controls the IL-12/18-IFN-γ Axis in a Model of Sterile Sepsis, Chronic Bacterial Infection, and Cancer.
Journal of immunology (Baltimore, Md. : 1950)202(5)1406-1416(2019 03)
Kunze FA,Bauer M,Komuczki J,Lanzinger M,Gunasekera K,Hopp AK,Lehmann M,Becher B,Müller A,Hottiger MO

DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD
Nature communications10(1)1307(2019 03)
Zhang D,Hu X,Li J,Liu J,Baks-Te Bulte L,Wiersma M,Malik NU,van Marion DMS,Tolouee M,Hoogstra-Berends F,Lanters EAH,van Roon AM,de Vries AAF,Pijnappels DA,de Groot NMS,Henning RH,Brundel BJJM

Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration.
Science signaling12(568)(2019 02)
Allocca M,Corrigan JJ,Mazumder A,Fake KR,Samson LD

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Parp1 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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