Bacterial infections can be life-threatening. With increasing numbers of antibiotic-resistant bacteria, there is a desperate need for new infection control approaches. A recently published study identified a new approach in treating antibiotic-resistant bacterial infections.

In this study, the authors tested the antibiotic activity of a membrane-active lipopeptide, C₁₀OOc₁₂O, and found that it sensitized gram-negative bacilli (GNB) to host antibacterial proteins and various antibiotics both in vivo and in vitro. Noticeably, in mice subjected to antibiotic-resistant bacterial infections, 100% of the mice injected with a placebo or traditional antibiotic did not survive, whereas C₁₀OOc₁₂O alone increased the survival rate of mice to 40%. In combination with a traditional antibiotic, C₁₀OOc₁₂O treatment increased the survival rate to 60%. Overall, this study suggested a new approaching to treating antibiotic-resistant bacterial infections by using a lipopeptide on its own or in combination with other antibiotics.

• Joanna Jammal et al. Eliciting improved antibacterial efficacy of host proteins in the presence of antibiotics. FASEB (2017). DOI:  10.1096/fj.201700652R

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