Catalog Products » Recombinant Proteins » Immune Checkpoint Proteins

Overview

The clinical study of immune checkpoint proteins achieved great success, making immunotherapy a promising method to treat cancer. Immune checkpoints are involved in a series of immunomodulatory pathways that can either co-stimulate or co-inhibit the immune response. Co-stimulatory immune checkpoints enhance the body's immune response against pathogens. Co-inhibitory immune-checkpoints can negatively regulate T cell's activity to protect against pro-inflammatory reactions. Targets, such as PD-1, PD-L1, B7, CD28, TIM and CD226, are very hot in cancer treatment.

GenScript immune checkpoint recombinant proteins passed a variety of activity testing and are featured with high purity and batch to batch stability. They are used as immunogens for the production of GenScript Immune Checkpoint Antibodies.

Application

number 1

Modulate immune responses

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Identify binding partners

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Discover novel drugs

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Antibody production

Proteins

Product Overview

ligand/ receptor Product Cat.no
4-1BB 4-1BB (CD137) Fc Chimera, Human Z03382
B7-1 B7-1(CD80) Fc Chimera, Human Z03409
B7-2 B7-2/CD86 Fc Chimera, Human Z03416
B7-2/CD86 Fc His, Human Z03452
B7-H2 B7-H2/ICOSLG Fc Chimera, Human Z03414
B7-H2/ICOSLG, His, Human Z03415
B7-H3 B7-H3 Fc Chimera, Human Z03426
B7-H3, His, Human Z03427
CD19 CD19 Fc Chimera, Human Z03407
CD25 CD25/IL-2Rα Fc Chimera, Human Z03400
CD28 CD28 Fc Chimera, Human Z03413
CD40L CD40L/CD154/TRAP, Human Z02022
sCD40L, Human Z02727
CD47 CD47 Fc Chimera, Human Z03418
CD47, His, Human Z03419
CTLA4 CTLA-4 Fc Chimera, Human Z03373
GITR GITR Ligand Fc Chimera, Human Z03446
GITR Fc Chimera, Human Z03440
HVEM HVEM-Fc, Human Z03224
OX40 OX40/TNFRSF4, His, Human Z03438
PD-1 PD-1 Fc Chimera, Human Z03370
PD-1, His, Human Z03424
PD-L1 PD-L1 Fc Chimera, Human Z03371
PD-L1, His, Human Z03425
PD-L2 PD-L2 Fc Chimera, Human Z03417
PVR PVR/CD155 Fc Chimera, Human Z03435
PVR/CD155, His, Human Z03436
SIRP SIRPα Fc Chimera, Human Z03420
SIRPα, His, Human Z03421
TIGIT TIGIT Fc Chimera, Human Z03439
TIM3 TIM-3 Fc Chimera, Human Z03392
TIM-3 Fc Chimera, Mouse Z03401
TIM-3, His, Mouse Z03402

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