Home » Gene Synthesis & Molecular Biology Services » ORF » Hot Human pathways » MAPK family signaling cascades
About the MAPK family signaling cascades pathway
The mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gene expression, metabolism, proliferation, differentiation and apoptosis, among others.
The classic MAPK cascades, including the ERK1/2 pathway, the p38 MAPK pathway, the JNK pathway and the ERK5 pathway are characterized by three tiers of sequentially acting, activating kinases (reviewed in Kryiakis and Avruch, 2012; Cargnello and Roux, 2011).
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
274 geneClick for more »
Gene Symbol | Full Name |
---|---|
ACTN2 | actinin, alpha 2 |
ANGPT1 | angiopoietin 1 |
ARAF | A-Raf proto-oncogene, serine/threonine kinase |
ARRB1 | arrestin, beta 1 |
ARRB2 | arrestin, beta 2 |
BRAF | B-Raf proto-oncogene, serine/threonine kinase |
BTC | betacellulin |
CALM1 | calmodulin 1 (phosphorylase kinase, delta) |
CALM2 | calmodulin 2 (phosphorylase kinase, delta) |
CALM3 | calmodulin 3 (phosphorylase kinase, delta) |
CAMK2A | calcium/calmodulin-dependent protein kinase II alpha |
CAMK2B | calcium/calmodulin-dependent protein kinase II beta |
CAMK2D | calcium/calmodulin-dependent protein kinase II delta |
CAMK2G | calcium/calmodulin-dependent protein kinase II gamma |
CCND3 | cyclin D3 |
CDK1 | cyclin-dependent kinase 1 |
42985 | septin 7 |
CDC42 | cell division cycle 42 |
CSF2 | colony stimulating factor 2 (granulocyte-macrophage) |
CSF2RA | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) |
CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) |
CSK | c-src tyrosine kinase |
DLG4 | discs, large homolog 4 (Drosophila) |
HBEGF | heparin-binding EGF-like growth factor |
DUSP1 | dual specificity phosphatase 1 |
DUSP2 | dual specificity phosphatase 2 |
DUSP4 | dual specificity phosphatase 4 |
DUSP5 | dual specificity phosphatase 5 |
DUSP6 | dual specificity phosphatase 6 |
DUSP7 | dual specificity phosphatase 7 |
DUSP8 | dual specificity phosphatase 8 |
DUSP9 | dual specificity phosphatase 9 |
EGF | epidermal growth factor |
EGFR | epidermal growth factor receptor |
ERBB2 | erb-b2 receptor tyrosine kinase 2 |
ERBB3 | erb-b2 receptor tyrosine kinase 3 |
ERBB4 | erb-b2 receptor tyrosine kinase 4 |
EREG | epiregulin |
ETV4 | ets variant 4 |
FGA | fibrinogen alpha chain |
FGB | fibrinogen beta chain |
FGF1 | fibroblast growth factor 1 (acidic) |
FGF2 | fibroblast growth factor 2 (basic) |
FGF3 | fibroblast growth factor 3 |
FGF4 | fibroblast growth factor 4 |
FGF5 | fibroblast growth factor 5 |
FGF6 | fibroblast growth factor 6 |
FGF7 | fibroblast growth factor 7 |
FGF8 | fibroblast growth factor 8 (androgen-induced) |
FGF9 | fibroblast growth factor 9 |
FGF10 | fibroblast growth factor 10 |
FGFR1 | fibroblast growth factor receptor 1 |
FGFR3 | fibroblast growth factor receptor 3 |
FGFR2 | fibroblast growth factor receptor 2 |
FGFR4 | fibroblast growth factor receptor 4 |
FGG | fibrinogen gamma chain |
FOXO1 | forkhead box O1 |
FOXO3 | forkhead box O3 |
FN1 | fibronectin 1 |
FYN | FYN proto-oncogene, Src family tyrosine kinase |
GRB2 | growth factor receptor-bound protein 2 |
GRIN1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 |
GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B |
GRIN2C | glutamate receptor, ionotropic, N-methyl D-aspartate 2C |
GRIN2D | glutamate receptor, ionotropic, N-methyl D-aspartate 2D |
NRG1 | neuregulin 1 |
HRAS | Harvey rat sarcoma viral oncogene homolog |
HSPB1 | heat shock 27kDa protein 1 |
DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 |
IL2 | interleukin 2 |
IL2RA | interleukin 2 receptor, alpha |
IL2RB | interleukin 2 receptor, beta |
IL2RG | interleukin 2 receptor, gamma |
IL3 | interleukin 3 |
IL3RA | interleukin 3 receptor, alpha (low affinity) |
IL5 | interleukin 5 |
IL5RA | interleukin 5 receptor, alpha |
IL6 | interleukin 6 |
IL6R | interleukin 6 receptor |
IL6ST | interleukin 6 signal transducer |
IRS1 | insulin receptor substrate 1 |
ITGA2B | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) |
ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
JAK1 | Janus kinase 1 |
JAK2 | Janus kinase 2 |
JAK3 | Janus kinase 3 |
JUN | jun proto-oncogene |
KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
KRAS | Kirsten rat sarcoma viral oncogene homolog |
MARK3 | MAP/microtubule affinity-regulating kinase 3 |
KITLG | KIT ligand |
MAP3K11 | mitogen-activated protein kinase kinase kinase 11 |
MOV10 | Mov10 RISC complex RNA helicase |
MYC | v-myc avian myelocytomatosis viral oncogene homolog |
NCAM1 | neural cell adhesion molecule 1 |
NEFL | neurofilament, light polypeptide |
NF1 | neurofibromin 1 |
NRAS | neuroblastoma RAS viral (v-ras) oncogene homolog |
PEBP1 | phosphatidylethanolamine binding protein 1 |