IRS1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IRS1
Entrez Gene ID	3667
Full Name	insulin receptor substrate 1
Synonyms	HIRS-1
General protein information	Preferred Names insulin receptor substrate 1 Names insulin receptor substrate 1 IRS-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q36.3
Summary	This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009].
Disorder MIM:	147545
Disorder Html:	{Diabetes mellitus, noninsulin-dependent}, 125853 (3); {Coronary artery disease, susceptibility to} (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005544.2	NP_005535.1	insulin receptor substrate 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Irs1	NP_037101.1
Gallus gallus (chicken)	IRS1	XP_004951158.1
Homo sapiens (human)	IRS1	NP_005535.1
Pan troglodytes (chimpanzee)	IRS1	XP_001134895.1
Xenopus tropicalis (tropical clawed frog)	LOC100495320	XP_004914519.1
Canis lupus familiaris (dog)	IRS1	XP_543274.3
Danio rerio (zebrafish)	irs1	XP_005157831.1
Bos taurus (cattle)	IRS1	XP_003585821.1
Mus musculus (house mouse)	Irs1	NP_034700.2

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of microRNA-183 expression resists human umbilical vascular endothelial cells injury by upregulating expression of IRS1.
Zhang Y, Zhan Y, Liu D, Yu B
Drug delivery26(1)612-621(2019 Dec)

IRS1- rs10498210 G/A and CCR5-59029 A/G polymorphisms in patients with type 2 diabetes in Kurdistan.
Keshavarzi F, Golsheh S
Molecular genetics & genomic medicine7(5)e631(2019 05)

MicroRNA‑466 inhibits cell proliferation and invasion in osteosarcoma by directly targeting insulin receptor substrate 1.
Sun Y, Zhou J, Shi L, Li J, Chen J
Molecular medicine reports19(4)3345-3352(2019 Apr)

Association of IRS1 genetic variants with glucose control and insulin resistance in type 2 diabetic patients from Bosnia and Herzegovina.
Mahmutovic L, Bego T, Sterner M, Gremsperger G, Ahlqvist E, Velija Asimi Z, Prnjavorac B, Hamad N, Causevic A, Groop L, Semiz S
Drug metabolism and personalized therapy34(1)(2019 03)

AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cells.
Cheng LC, Chen YL, Cheng AN, Lee AY, Cho CY, Huang JS, Chuang SE
Journal of biomedical science25(1)80(2018 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following IRS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IRS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu24973	NM_005544.2 Latest version!	Homo sapiens insulin receptor substrate 1 (IRS1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IRS1 ( NM_005544.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005535.1 Homo sapiens insulin receptor substrate 1 (IRS1), mRNA.

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CloneID	OHu24973
Clone ID Related Accession (Same CDS sequence)	NM_005544.2
Accession Version	NM_005544.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3729bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Homo sapiens(human)
Product	insulin receptor substrate 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC053895.1, AC010735.11 and AW469017.1. This sequence is a reference standard in the RefSeqGene project. On May 8, 2008 this sequence version replaced NM_005544.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC053895.1, SRR1803611.103322.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159912 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGAGCC CTCCGGAGAG CGATGGCTTC TCGGACGTGC GCAAGGTGGG CTACCTGCGC 
AAACCCAAGA GCATGCACAA ACGCTTCTTC GTACTGCGCG CGGCCAGCGA GGCTGGGGGC 
CCGGCGCGCC TCGAGTACTA CGAGAACGAG AAGAAGTGGC GGCACAAGTC GAGCGCCCCC 
AAACGCTCGA TCCCCCTTGA GAGCTGCTTC AACATCAACA AGCGGGCTGA CTCCAAGAAC 
AAGCACCTGG TGGCTCTCTA CACCCGGGAC GAGCACTTTG CCATCGCGGC GGACAGCGAG 
GCCGAGCAAG ACAGCTGGTA CCAGGCTCTC CTACAGCTGC ACAACCGTGC TAAGGGCCAC 
CACGACGGAG CTGCGGCCCT CGGGGCGGGA GGTGGTGGGG GCAGCTGCAG CGGCAGCTCC 
GGCCTTGGTG AGGCTGGGGA GGACTTGAGC TACGGTGACG TGCCCCCAGG ACCCGCATTC 
AAAGAGGTCT GGCAAGTGAT CCTGAAGCCC AAGGGCCTGG GTCAGACAAA GAACCTGATT 
GGTATCTACC GCCTTTGCCT GACCAGCAAG ACCATCAGCT TCGTGAAGCT GAACTCGGAG 
GCAGCGGCCG TGGTGCTGCA GCTGATGAAC ATCAGGCGCT GTGGCCACTC GGAAAACTTC 
TTCTTCATCG AGGTGGGCCG TTCTGCCGTG ACGGGGCCCG GGGAGTTCTG GATGCAGGTG 
GATGACTCTG TGGTGGCCCA GAACATGCAC GAGACCATCC TGGAGGCCAT GCGGGCCATG 
AGTGATGAGT TCCGCCCTCG CAGCAAGAGC CAGTCCTCGT CCAACTGCTC TAACCCCATC 
AGCGTCCCCC TGCGCCGGCA CCATCTCAAC AATCCCCCGC CCAGCCAGGT GGGGCTGACC 
CGCCGATCAC GCACTGAGAG CATCACCGCC ACCTCCCCGG CCAGCATGGT GGGCGGGAAG 
CCAGGCTCCT TCCGTGTCCG CGCCTCCAGT GACGGCGAAG GCACCATGTC CCGCCCAGCC 
TCGGTGGACG GCAGCCCTGT GAGTCCCAGC ACCAACAGAA CCCACGCCCA CCGGCATCGG 
GGCAGCGCCC GGCTGCACCC CCCGCTCAAC CACAGCCGCT CCATCCCCAT GCCGGCTTCC 
CGCTGCTCGC CTTCGGCCAC CAGCCCGGTC AGTCTGTCGT CCAGTAGCAC CAGTGGCCAT 
GGCTCCACCT CGGATTGTCT CTTCCCACGG CGATCTAGTG CTTCGGTGTC TGGTTCCCCC 
AGCGATGGCG GTTTCATCTC CTCGGATGAG TATGGCTCCA GTCCCTGCGA TTTCCGGAGT 
TCCTTCCGCA GTGTCACTCC GGATTCCCTG GGCCACACCC CACCAGCCCG CGGTGAGGAG 
GAGCTAAGCA ACTATATCTG CATGGGTGGC AAGGGGCCCT CCACCCTGAC CGCCCCCAAC 
GGTCACTACA TTTTGTCTCG GGGTGGCAAT GGCCACCGCT GCACCCCAGG AACAGGCTTG 
GGCACGAGTC CAGCCTTGGC TGGGGATGAA GCAGCCAGTG CTGCAGATCT GGATAATCGG 
TTCCGAAAGA GAACTCACTC GGCAGGCACA TCCCCTACCA TTACCCACCA GAAGACCCCG 
TCCCAGTCCT CAGTGGCTTC CATTGAGGAG TACACAGAGA TGATGCCTGC CTACCCACCA 
GGAGGTGGCA GTGGAGGCCG ACTGCCGGGA CACAGGCACT CCGCCTTCGT GCCCACCCGC 
TCCTACCCAG AGGAGGGTCT GGAAATGCAC CCCTTGGAGC GTCGGGGGGG GCACCACCGC 
CCAGACAGCT CCACCCTCCA CACGGATGAT GGCTACATGC CCATGTCCCC AGGGGTGGCC 
CCAGTGCCCA GTGGCCGAAA GGGCAGTGGA GACTATATGC CCATGAGCCC CAAGAGCGTA 
TCTGCCCCAC AGCAGATCAT CAATCCCATC AGACGCCATC CCCAGAGAGT GGACCCCAAT 
GGCTACATGA TGATGTCCCC CAGCGGTGGC TGCTCTCCTG ACATTGGAGG TGGCCCCAGC 
AGCAGCAGCA GCAGCAGCAA CGCCGTCCCT TCCGGGACCA GCTATGGAAA GCTGTGGACA 
AACGGGGTAG GGGGCCACCA CTCTCATGTC TTGCCTCACC CCAAACCCCC AGTGGAGAGC 
AGCGGTGGTA AGCTCTTACC TTGCACAGGT GACTACATGA ACATGTCACC AGTGGGGGAC 
TCCAACACCA GCAGCCCCTC CGACTGCTAC TACGGCCCTG AGGACCCCCA GCACAAGCCA 
GTCCTCTCCT ACTACTCATT GCCAAGATCC TTTAAGCACA CCCAGCGCCC CGGGGAGCCG 
GAGGAGGGTG CCCGGCATCA GCACCTCCGC CTTTCCACTA GCTCTGGTCG CCTTCTCTAT 
GCTGCAACAG CAGATGATTC TTCCTCTTCC ACCAGCAGCG ACAGCCTGGG TGGGGGATAC 
TGCGGGGCTA GGCTGGAGCC CAGCCTTCCA CATCCCCACC ATCAGGTTCT GCAGCCCCAT 
CTGCCTCGAA AGGTGGACAC AGCTGCTCAG ACCAATAGCC GCCTGGCCCG GCCCACGAGG 
CTGTCCCTGG GGGATCCCAA GGCCAGCACC TTACCTCGGG CCCGAGAGCA GCAGCAGCAG 
CAGCAGCCCT TGCTGCACCC TCCAGAGCCC AAGAGCCCGG GGGAATATGT CAATATTGAA 
TTTGGGAGTG ATCAGTCTGG CTACTTGTCT GGCCCGGTGG CTTTCCACAG CTCACCTTCT 
GTCAGGTGTC CATCCCAGCT CCAGCCAGCT CCCAGAGAGG AAGAGACTGG CACTGAGGAG 
TACATGAAGA TGGACCTGGG GCCGGGCCGG AGGGCAGCCT GGCAGGAGAG CACTGGGGTC 
GAGATGGGCA GACTGGGCCC TGCACCTCCC GGGGCTGCTA GCATTTGCAG GCCTACCCGG 
GCAGTGCCCA GCAGCCGGGG TGACTACATG ACCATGCAGA TGAGTTGTCC CCGTCAGAGC 
TACGTGGACA CCTCGCCAGC TGCCCCTGTA AGCTATGCTG ACATGCGAAC AGGCATTGCT 
GCAGAGGAGG TGAGCCTGCC CAGGGCCACC ATGGCTGCTG CCTCCTCATC CTCAGCAGCC 
TCTGCTTCCC CGACTGGGCC TCAAGGGGCA GCAGAGCTGG CTGCCCACTC GTCCCTGCTG 
GGGGGCCCAC AAGGACCTGG GGGCATGAGC GCCTTCACCC GGGTGAACCT CAGTCCTAAC 
CGCAACCAGA GTGCCAAAGT GATCCGTGCA GACCCACAAG GGTGCCGGCG GAGGCATAGC 
TCCGAGACTT TCTCCTCAAC ACCCAGTGCC ACCCGGGTGG GCAACACAGT GCCCTTTGGA 
GCGGGGGCAG CAGTAGGGGG CGGTGGCGGT AGCAGCAGCA GCAGCGAGGA TGTGAAACGC 
CACAGCTCTG CTTCCTTTGA GAATGTGTGG CTGAGGCCTG GGGAGCTTGG GGGAGCCCCC 
AAGGAGCCAG CCAAACTGTG TGGGGCTGCT GGGGGTTTGG AGAATGGTCT TAACTACATA 
GACCTGGATT TGGTCAAGGA CTTCAAACAG TGCCCTCAGG AGTGCACCCC TGAACCGCAG 
CCTCCCCCAC CCCCACCCCC TCATCAACCC CTGGGCAGCG GTGAGAGCAG CTCCACCCGC 
CGCTCAAGTG AGGATTTAAG CGCCTATGCC AGCATCAGTT TCCAGAAGCA GCCAGAGGAC 
CGTCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005535.1
CDS	53..3781
Translation	MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGHHDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPNGHYILSRGGNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTPSQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTRSYPEEGLEMHPLERRGGHHRPDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTNGVGGHHSHVLPHPKPPVESSGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQPLLHPPEPKSPGEYVNIEFGSDQSGYLSGPVAFHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGVEMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIAAEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSPNRNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSSEDVKRHSSASFENVWLRPGELGGAPKEPAKLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEPQPPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ

Target ORF information:

RefSeq Version	NM_005544.2
Organism	Homo sapiens(human)
Definition	Homo sapiens insulin receptor substrate 1 (IRS1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005544.2

ORF Insert Sequence:

ATGGCGAGCC CTCCGGAGAG CGATGGCTTC TCGGACGTGC GCAAGGTGGG CTACCTGCGC 
AAACCCAAGA GCATGCACAA ACGCTTCTTC GTACTGCGCG CGGCCAGCGA GGCTGGGGGC 
CCGGCGCGCC TCGAGTACTA CGAGAACGAG AAGAAGTGGC GGCACAAGTC GAGCGCCCCC 
AAACGCTCGA TCCCCCTTGA GAGCTGCTTC AACATCAACA AGCGGGCTGA CTCCAAGAAC 
AAGCACCTGG TGGCTCTCTA CACCCGGGAC GAGCACTTTG CCATCGCGGC GGACAGCGAG 
GCCGAGCAAG ACAGCTGGTA CCAGGCTCTC CTACAGCTGC ACAACCGTGC TAAGGGCCAC 
CACGACGGAG CTGCGGCCCT CGGGGCGGGA GGTGGTGGGG GCAGCTGCAG CGGCAGCTCC 
GGCCTTGGTG AGGCTGGGGA GGACTTGAGC TACGGTGACG TGCCCCCAGG ACCCGCATTC 
AAAGAGGTCT GGCAAGTGAT CCTGAAGCCC AAGGGCCTGG GTCAGACAAA GAACCTGATT 
GGTATCTACC GCCTTTGCCT GACCAGCAAG ACCATCAGCT TCGTGAAGCT GAACTCGGAG 
GCAGCGGCCG TGGTGCTGCA GCTGATGAAC ATCAGGCGCT GTGGCCACTC GGAAAACTTC 
TTCTTCATCG AGGTGGGCCG TTCTGCCGTG ACGGGGCCCG GGGAGTTCTG GATGCAGGTG 
GATGACTCTG TGGTGGCCCA GAACATGCAC GAGACCATCC TGGAGGCCAT GCGGGCCATG 
AGTGATGAGT TCCGCCCTCG CAGCAAGAGC CAGTCCTCGT CCAACTGCTC TAACCCCATC 
AGCGTCCCCC TGCGCCGGCA CCATCTCAAC AATCCCCCGC CCAGCCAGGT GGGGCTGACC 
CGCCGATCAC GCACTGAGAG CATCACCGCC ACCTCCCCGG CCAGCATGGT GGGCGGGAAG 
CCAGGCTCCT TCCGTGTCCG CGCCTCCAGT GACGGCGAAG GCACCATGTC CCGCCCAGCC 
TCGGTGGACG GCAGCCCTGT GAGTCCCAGC ACCAACAGAA CCCACGCCCA CCGGCATCGG 
GGCAGCGCCC GGCTGCACCC CCCGCTCAAC CACAGCCGCT CCATCCCCAT GCCGGCTTCC 
CGCTGCTCGC CTTCGGCCAC CAGCCCGGTC AGTCTGTCGT CCAGTAGCAC CAGTGGCCAT 
GGCTCCACCT CGGATTGTCT CTTCCCACGG CGATCTAGTG CTTCGGTGTC TGGTTCCCCC 
AGCGATGGCG GTTTCATCTC CTCGGATGAG TATGGCTCCA GTCCCTGCGA TTTCCGGAGT 
TCCTTCCGCA GTGTCACTCC GGATTCCCTG GGCCACACCC CACCAGCCCG CGGTGAGGAG 
GAGCTAAGCA ACTATATCTG CATGGGTGGC AAGGGGCCCT CCACCCTGAC CGCCCCCAAC 
GGTCACTACA TTTTGTCTCG GGGTGGCAAT GGCCACCGCT GCACCCCAGG AACAGGCTTG 
GGCACGAGTC CAGCCTTGGC TGGGGATGAA GCAGCCAGTG CTGCAGATCT GGATAATCGG 
TTCCGAAAGA GAACTCACTC GGCAGGCACA TCCCCTACCA TTACCCACCA GAAGACCCCG 
TCCCAGTCCT CAGTGGCTTC CATTGAGGAG TACACAGAGA TGATGCCTGC CTACCCACCA 
GGAGGTGGCA GTGGAGGCCG ACTGCCGGGA CACAGGCACT CCGCCTTCGT GCCCACCCGC 
TCCTACCCAG AGGAGGGTCT GGAAATGCAC CCCTTGGAGC GTCGGGGGGG GCACCACCGC 
CCAGACAGCT CCACCCTCCA CACGGATGAT GGCTACATGC CCATGTCCCC AGGGGTGGCC 
CCAGTGCCCA GTGGCCGAAA GGGCAGTGGA GACTATATGC CCATGAGCCC CAAGAGCGTA 
TCTGCCCCAC AGCAGATCAT CAATCCCATC AGACGCCATC CCCAGAGAGT GGACCCCAAT 
GGCTACATGA TGATGTCCCC CAGCGGTGGC TGCTCTCCTG ACATTGGAGG TGGCCCCAGC 
AGCAGCAGCA GCAGCAGCAA CGCCGTCCCT TCCGGGACCA GCTATGGAAA GCTGTGGACA 
AACGGGGTAG GGGGCCACCA CTCTCATGTC TTGCCTCACC CCAAACCCCC AGTGGAGAGC 
AGCGGTGGTA AGCTCTTACC TTGCACAGGT GACTACATGA ACATGTCACC AGTGGGGGAC 
TCCAACACCA GCAGCCCCTC CGACTGCTAC TACGGCCCTG AGGACCCCCA GCACAAGCCA 
GTCCTCTCCT ACTACTCATT GCCAAGATCC TTTAAGCACA CCCAGCGCCC CGGGGAGCCG 
GAGGAGGGTG CCCGGCATCA GCACCTCCGC CTTTCCACTA GCTCTGGTCG CCTTCTCTAT 
GCTGCAACAG CAGATGATTC TTCCTCTTCC ACCAGCAGCG ACAGCCTGGG TGGGGGATAC 
TGCGGGGCTA GGCTGGAGCC CAGCCTTCCA CATCCCCACC ATCAGGTTCT GCAGCCCCAT 
CTGCCTCGAA AGGTGGACAC AGCTGCTCAG ACCAATAGCC GCCTGGCCCG GCCCACGAGG 
CTGTCCCTGG GGGATCCCAA GGCCAGCACC TTACCTCGGG CCCGAGAGCA GCAGCAGCAG 
CAGCAGCCCT TGCTGCACCC TCCAGAGCCC AAGAGCCCGG GGGAATATGT CAATATTGAA 
TTTGGGAGTG ATCAGTCTGG CTACTTGTCT GGCCCGGTGG CTTTCCACAG CTCACCTTCT 
GTCAGGTGTC CATCCCAGCT CCAGCCAGCT CCCAGAGAGG AAGAGACTGG CACTGAGGAG 
TACATGAAGA TGGACCTGGG GCCGGGCCGG AGGGCAGCCT GGCAGGAGAG CACTGGGGTC 
GAGATGGGCA GACTGGGCCC TGCACCTCCC GGGGCTGCTA GCATTTGCAG GCCTACCCGG 
GCAGTGCCCA GCAGCCGGGG TGACTACATG ACCATGCAGA TGAGTTGTCC CCGTCAGAGC 
TACGTGGACA CCTCGCCAGC TGCCCCTGTA AGCTATGCTG ACATGCGAAC AGGCATTGCT 
GCAGAGGAGG TGAGCCTGCC CAGGGCCACC ATGGCTGCTG CCTCCTCATC CTCAGCAGCC 
TCTGCTTCCC CGACTGGGCC TCAAGGGGCA GCAGAGCTGG CTGCCCACTC GTCCCTGCTG 
GGGGGCCCAC AAGGACCTGG GGGCATGAGC GCCTTCACCC GGGTGAACCT CAGTCCTAAC 
CGCAACCAGA GTGCCAAAGT GATCCGTGCA GACCCACAAG GGTGCCGGCG GAGGCATAGC 
TCCGAGACTT TCTCCTCAAC ACCCAGTGCC ACCCGGGTGG GCAACACAGT GCCCTTTGGA 
GCGGGGGCAG CAGTAGGGGG CGGTGGCGGT AGCAGCAGCA GCAGCGAGGA TGTGAAACGC 
CACAGCTCTG CTTCCTTTGA GAATGTGTGG CTGAGGCCTG GGGAGCTTGG GGGAGCCCCC 
AAGGAGCCAG CCAAACTGTG TGGGGCTGCT GGGGGTTTGG AGAATGGTCT TAACTACATA 
GACCTGGATT TGGTCAAGGA CTTCAAACAG TGCCCTCAGG AGTGCACCCC TGAACCGCAG 
CCTCCCCCAC CCCCACCCCC TCATCAACCC CTGGGCAGCG GTGAGAGCAG CTCCACCCGC 
CGCTCAAGTG AGGATTTAAG CGCCTATGCC AGCATCAGTT TCCAGAAGCA GCCAGAGGAC 
CGTCAGTAG