Irs1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Irs1
Entrez Gene ID	25467
Full Name	insulin receptor substrate 1
Synonyms	IRS1IRM
General protein information	Preferred Names insulin receptor substrate 1 Names insulin receptor substrate 1 IRS-1 pp185
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q34
Summary	a docking protein; may act to link the insulin receptor kinase with enzymes regulating cellular growth and metabolism [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012969.1	NP_037101.1	insulin receptor substrate 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Irs1	NP_037101.1
Gallus gallus (chicken)	IRS1	XP_004951158.1
Homo sapiens (human)	IRS1	NP_005535.1
Pan troglodytes (chimpanzee)	IRS1	XP_001134895.1
Xenopus tropicalis (tropical clawed frog)	LOC100495320	XP_004914519.1
Canis lupus familiaris (dog)	IRS1	XP_543274.3
Danio rerio (zebrafish)	irs1	XP_005157831.1
Bos taurus (cattle)	IRS1	XP_003585821.1
Mus musculus (house mouse)	Irs1	NP_034700.2

Gene Ontology
Bibliography

Related articles in PubMed

IRS-1 targets TAZ to inhibit adipogenesis of rat bone marrow mesenchymal stem cells through PI3K-Akt and MEK-ERK pathways.
Wang N, Li Y, Li Z, Ma J, Wu X, Pan R, Wang Y, Gao L, Bao X, Xue P
European journal of pharmacology84911-21(2019 Apr)

[miR-494-3p reduces insulin sensitivity in diabetic cardiomyocytes by down-regulation of insulin receptor substrate 1].
Wu J, Qin XH, Hou ZX, Fu ZH, Li GH, Yang HY, Zhang X, Gao F
Sheng li xue bao : [Acta physiologica Sinica]71(2)271-278(2019 Apr)

Polyphenol-rich ethyl acetate fraction isolated from Molineria latifolia ameliorates insulin resistance in experimental diabetic rats via IRS1/AKT activation.
Ooi J, Adamu HA, Imam MU, Ithnin H, Ismail M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie98125-133(2018 Feb)

Tanshinone I alleviates insulin resistance in type 2 diabetes mellitus rats through IRS-1 pathway.
Wei Y, Gao J, Qin L, Xu Y, Wang D, Shi H, Xu T, Liu T
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie93352-358(2017 Sep)

The Insulin Receptor Plays a Critical Role in T Cell Function and Adaptive Immunity.
Fischer HJ, Sie C, Schumann E, Witte AK, Dressel R, van den Brandt J, Reichardt HM
Journal of immunology (Baltimore, Md. : 1950)198(5)1910-1920(2017 03)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Irs1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Irs1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13385	NM_012969.1 Latest version!	Rattus norvegicus insulin receptor substrate 1 (Irs1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$643.30 $919.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Irs1 ( NM_012969.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037101.1 Rattus norvegicus insulin receptor substrate 1 (Irs1), mRNA.

Price & Availability↑

CloneID	ORa13385
Clone ID Related Accession (Same CDS sequence)	NM_012969.1
Accession Version	NM_012969.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Rattus norvegicus(Norway rat)
Product	insulin receptor substrate 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X58375.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X58375.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906355, SAMN01906358 [ECO:0000348] ##Evidence-Data-END##

ATGGCGAGCC CTCCGGATAC CGATGGCTTC TCAGACGTGC GCAAGGTGGG TTACCTGCGC 
AAACCCAAGA GTATGCATAA GCGCTTTTTC GTGCTGCGGG CGGCCAGCGA GGCCGGGGGC 
CCGGCGCGCC TGGAGTATTA TGAGAACGAG AAGAAGTGGC GGCACAAGTC GAGCGCCCCC 
AAACGCTCGA TCCCCCTCGA GAGCTGTTTC AACATCAACA AGCGGGCTGA CTCCAAGAAC 
AAGCACCTGG TGGCTCTCTA CACCCGAGAC GAACACTTTG CCATTGCGGC GGATAGCGAG 
GCTGAACAAG ACAGCTGGTA CCAGGCTCTT CTGCAGCTGC ATAATCGGGC AAAGGCCCAC 
CATGACGGGG CTGGAGGAGG CTGCGGTGGT AGCTGCAGCG GCAGCTCTGG CGTCGGAGAG 
GCAGGGGAGG ACTTGAGCTA TGACACGGGC CCAGGACCCG CGTTCAAGGA GGTCTGGCAG 
GTTATCCTGA AACCCAAGGG CTTAGGTCAG ACAAAGAACT TGATTGGTAT CTACCGCCTC 
TGCCTGACCA GCAAGACCAT CAGCTTTGTG AAGCTCAACT CTGAGGCTGC CGCTGTGGTG 
CTGCAGCTGA TGAACATCAG ACGCTGTGGC CACTCAGAGA ACTTCTTCTT CATCGAGGTG 
GGGCGGTCAG CTGTGACCGG GCCCGGCGAG TTCTGGATGC AAGTGGATGA CTCCGTGGTG 
GCCCAGAACA TGCATGAGAC CATTCTAGAG GCCATGCGGG CCATGAGCGA TGAGTTTCGC 
CCGCGCACGA AAAGCCAATC TTCATCCAGT TGCTCCAACC CCATCAGTGT TCCCCTGCGC 
AGGCACCATC TCAACAATCC TCCGCCCAGC CAAGTGGGGC TGACTCGGAG ATCTCGAACT 
GAGAGCATCA CTGCCACCTC CCCTGCCAGT ATGGTGGGTG GGAAACCAGG TTCCTTCAGG 
GTGCGTGCCT CCAGCGATGG CGAAGGCACC ATGTCCCGTC CAGCATCAGT GGATGGCAGT 
CCTGTGAGCC CTAGCACCAA CAGGACCCAC GCCCATCGGC ATCGAGGCAG CTCCAGGTTG 
CACCCCCCAC TCAACCACAG CCGCTCCATC CCTATGCCTT CTTCACGATG CTCCCCTTCA 
GCCACCAGCC CAGTGAGCCT GTCATCCAGT AGTACCAGTG GCCACGGCTC CACTTCAGAC 
TGTCTCTTCC CGAGGCGCTC TAGTGCTTCC GTGTCCGGTT CTCCTAGCGA TGGCGGTTTC 
ATCTCTTCTG ATGAGTATGG CTCTAGTCCC TGCGATTTCC GAAGTTCCTT CCGCAGTGTC 
ACCCCAGATT CCCTGGGCCA CACCCCACCA GCCAGGGGTG AGGAGGAGCT GAGCAACTAT 
ATCTGCATGG GTGGCAAGGG AGCCTCCACC TTGACAGCTC CCAATGGTCA CTACATTTTG 
TCTAGGGGTG GCAACGGCCA TCGCTACATC CCAGGTGCTA CCATGGGGAC AAGCCCGGCG 
CTGACTGGAG ACGAAGCCGC TGGTGCAGCA GATCTGGATA ACCGGTTTCG GAAGAGAACT 
CACTCGGCTG GCACGTCCCC CACCATATCC CACCAGAAGA CCCCCTCGCA GTCCTCAGTG 
GTTTCTATTG AGGAATATAC AGAGATGATG CCCGCTGCCT ACCCACCAGG AGGTGGCAGT 
GGAGGCCGAC TGCCCGGCTA CCGGCATTCC GCCTTCGTGC CCACCCACTC CTATCCCGAG 
GAGGGTCTAG AGATGCACCA CTTGGAACGT CGTGGGGGCC ACCACCGTCC AGACTCCTCC 
AACCTCCACA CCGATGATGG CTACATGCCC ATGTCTCCCG GAGTGGCTCC AGTGCCCAGC 
AACCGCAAAG GAAATGGGGA CTATATGCCC ATGAGCCCCA AGAGTGTATC TGCCCCCCAG 
CAGATCATTA ACCCCATCAG GCGCCACCCA CAGAGAGTGG ACCCCAATGG CTACATGATG 
ATGTCTCCCA GTGGTAGTTG CTCTCCTGAC ATTGGAGGTG GGTCTTGCAG CAGTAGCAGC 
ATCAGCGCAG CCCCTTCTGG GAGCAGCTAT GGGAAGCCAT GGACAAACGG AGTAGGGGGG 
CACCATACCC ATGCCCTTCC CCATGCCAAA CCTCCTGTTG AGAGCGGTGG TGGTAAGCTC 
TTGCCTTGCA CTGGTGACTA CATGAACATG TCGCCAGTGG GAGATTCCAA CACCAGCAGC 
CCCTCAGAAT GCTACTATGG CCCAGAAGAT CCCCAGCACA AGCCTGTCCT CTCCTACTAC 
TCATTACCAA GGTCCTTTAA GCACACCCAG CGCCCTGGGG AGCCAGAGGA GGGTGCCAGG 
CACCAGCATC TTCGTCTCTC TTCAAGCTCT GGACGCCTTC GCTATACCGC AACTGCCGAA 
GATTCCTCCT CTTCCACCAG CAGCGACAGC CTGGGTGGGG GTTACTGTGG GGCTAGGCCA 
GAGTCTAGCG TCACACATCC CCACCACCAT GCCTTGCAGC CCCATCTGCC TCGAAAGGTA 
GACACAGCTG CACAGACCAA CAGCCGCCTG GCTCGACCCA CAAGGCTGTC CTTGGGGGAT 
CCCAAGGCAA GCACTTTACC CCGGGTACGA GAGCAACAGC AGCAGCAGCA ACAGCAGCAG 
CAGTCTTCCC TGCACCCTCC CGAGCCCAAA AGCCCAGGAG AATATGTGAA TATTGAATTC 
GGGAGTGGCC AGCCAGGCTA TTTAGCTGGC CCTGCAACTT CCCGTAGCTC CCCTTCAGTT 
CGATGTCTAC CCCAGCTCCA CCCAGCTCCC AGAGAAGAGA CTGGCTCGGA AGAGTACATG 
AACATGGACT TGGGGCCAGG CCGGAGGGCA ACCTGGCAGG AGAGTGGTGG AGTTGAGTTG 
GGCAGAGTAG GCCCTGCACC TCCAGGGGCT GCTTCCATTT GTAGGCCAAC CCGGTCGGTG 
CCAAATAGCC GTGGTGATTA CATGACCATG CAGATAGGTT GTCCTCGTCA AAGCTATGTG 
GATACCTCAC CAGTGGCCCC AGTCAGCTAT GCTGACATGC GGACAGGCAT TGCTGCAGAG 
AAGGTGAGCC TGCCCAGAAC CACAGGAGCT GCCCCCCCTC CATCCTCCAC AGCCTCTGCT 
TCTGCTTCTG TTACACCTCA AGGGGCCGCT GAGCAGGCCG CTCACTCTTC CTTGCTGGGA 
GGCCCTCAGG GACCTGGGGG CATGAGCGCA TTCACCAGGG TGAACCTAAG TCCCAACCAT 
AACCAGAGTG CCAAAGTGAT TCGTGCAGAC ACTCAAGGCT GCCGGAGGAG GCACAGCTCC 
GAGACCTTCT CGGCGCCTAC GCGGGCTGCC AACACAGTGT CTTTTGGAGC AGGGGCTGCA 
GGAGGGGGCA GCGGTGGTGG CAGTGAGGAT GTGAAACGCC ACAGCTCTGC ATCCTTTGAG 
AATGTGTGGC TGAGACCCGG GGATCTAGGG GGAGCATCCA AGGAGTCGGC TCCAGGGTGC 
GGGGCTGCCG GGGGATTGGA GAAGAGTCTT AACTATATAG ACTTGGATTT GGTCAAGGAT 
GTTAAGCAGC ACCCTCAAGA CTGCCCCTCT CAACAGCAGT CCCTGCCACC CCCTCCCCCT 
CACCAACCCT TAGGCAGCAA TGAGGGCAGC TCCCCAAGAC GCTCCAGTGA GGATTTAAGC 
ACCTATGCCA GCATCAACTT CCAGAAGCAA CCAGAGGACC GTCAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037101.1
CDS	589..4296
Translation	MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAHHDGAGGGCGGSCSGSSGVGEAGEDLSYDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRTKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPNGHYILSRGGNGHRYIPGATMGTSPALTGDEAAGAADLDNRFRKRTHSAGTSPTISHQKTPSQSSVVSIEEYTEMMPAAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDSSNLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGSCSPDIGGGSCSSSSISAAPSGSSYGKPWTNGVGGHHTHALPHAKPPVESGGGKLLPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSSSSGRLRYTATAEDSSSSTSSDSLGGGYCGARPESSVTHPHHHALQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQQQQQSSLHPPEPKSPGEYVNIEFGSGQPGYLAGPATSRSSPSVRCLPQLHPAPREETGSEEYMNMDLGPGRRATWQESGGVELGRVGPAPPGAASICRPTRSVPNSRGDYMTMQIGCPRQSYVDTSPVAPVSYADMRTGIAAEKVSLPRTTGAAPPPSSTASASASVTPQGAAEQAAHSSLLGGPQGPGGMSAFTRVNLSPNHNQSAKVIRADTQGCRRRHSSETFSAPTRAANTVSFGAGAAGGGSGGGSEDVKRHSSASFENVWLRPGDLGGASKESAPGCGAAGGLEKSLNYIDLDLVKDVKQHPQDCPSQQQSLPPPPPHQPLGSNEGSSPRRSSEDLSTYASINFQKQPEDRQ

Target ORF information:

RefSeq Version	NM_012969.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus insulin receptor substrate 1 (Irs1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012969.1

ORF Insert Sequence:

ATGGCGAGCC CTCCGGATAC CGATGGCTTC TCAGACGTGC GCAAGGTGGG TTACCTGCGC 
AAACCCAAGA GTATGCATAA GCGCTTTTTC GTGCTGCGGG CGGCCAGCGA GGCCGGGGGC 
CCGGCGCGCC TGGAGTATTA TGAGAACGAG AAGAAGTGGC GGCACAAGTC GAGCGCCCCC 
AAACGCTCGA TCCCCCTCGA GAGCTGTTTC AACATCAACA AGCGGGCTGA CTCCAAGAAC 
AAGCACCTGG TGGCTCTCTA CACCCGAGAC GAACACTTTG CCATTGCGGC GGATAGCGAG 
GCTGAACAAG ACAGCTGGTA CCAGGCTCTT CTGCAGCTGC ATAATCGGGC AAAGGCCCAC 
CATGACGGGG CTGGAGGAGG CTGCGGTGGT AGCTGCAGCG GCAGCTCTGG CGTCGGAGAG 
GCAGGGGAGG ACTTGAGCTA TGACACGGGC CCAGGACCCG CGTTCAAGGA GGTCTGGCAG 
GTTATCCTGA AACCCAAGGG CTTAGGTCAG ACAAAGAACT TGATTGGTAT CTACCGCCTC 
TGCCTGACCA GCAAGACCAT CAGCTTTGTG AAGCTCAACT CTGAGGCTGC CGCTGTGGTG 
CTGCAGCTGA TGAACATCAG ACGCTGTGGC CACTCAGAGA ACTTCTTCTT CATCGAGGTG 
GGGCGGTCAG CTGTGACCGG GCCCGGCGAG TTCTGGATGC AAGTGGATGA CTCCGTGGTG 
GCCCAGAACA TGCATGAGAC CATTCTAGAG GCCATGCGGG CCATGAGCGA TGAGTTTCGC 
CCGCGCACGA AAAGCCAATC TTCATCCAGT TGCTCCAACC CCATCAGTGT TCCCCTGCGC 
AGGCACCATC TCAACAATCC TCCGCCCAGC CAAGTGGGGC TGACTCGGAG ATCTCGAACT 
GAGAGCATCA CTGCCACCTC CCCTGCCAGT ATGGTGGGTG GGAAACCAGG TTCCTTCAGG 
GTGCGTGCCT CCAGCGATGG CGAAGGCACC ATGTCCCGTC CAGCATCAGT GGATGGCAGT 
CCTGTGAGCC CTAGCACCAA CAGGACCCAC GCCCATCGGC ATCGAGGCAG CTCCAGGTTG 
CACCCCCCAC TCAACCACAG CCGCTCCATC CCTATGCCTT CTTCACGATG CTCCCCTTCA 
GCCACCAGCC CAGTGAGCCT GTCATCCAGT AGTACCAGTG GCCACGGCTC CACTTCAGAC 
TGTCTCTTCC CGAGGCGCTC TAGTGCTTCC GTGTCCGGTT CTCCTAGCGA TGGCGGTTTC 
ATCTCTTCTG ATGAGTATGG CTCTAGTCCC TGCGATTTCC GAAGTTCCTT CCGCAGTGTC 
ACCCCAGATT CCCTGGGCCA CACCCCACCA GCCAGGGGTG AGGAGGAGCT GAGCAACTAT 
ATCTGCATGG GTGGCAAGGG AGCCTCCACC TTGACAGCTC CCAATGGTCA CTACATTTTG 
TCTAGGGGTG GCAACGGCCA TCGCTACATC CCAGGTGCTA CCATGGGGAC AAGCCCGGCG 
CTGACTGGAG ACGAAGCCGC TGGTGCAGCA GATCTGGATA ACCGGTTTCG GAAGAGAACT 
CACTCGGCTG GCACGTCCCC CACCATATCC CACCAGAAGA CCCCCTCGCA GTCCTCAGTG 
GTTTCTATTG AGGAATATAC AGAGATGATG CCCGCTGCCT ACCCACCAGG AGGTGGCAGT 
GGAGGCCGAC TGCCCGGCTA CCGGCATTCC GCCTTCGTGC CCACCCACTC CTATCCCGAG 
GAGGGTCTAG AGATGCACCA CTTGGAACGT CGTGGGGGCC ACCACCGTCC AGACTCCTCC 
AACCTCCACA CCGATGATGG CTACATGCCC ATGTCTCCCG GAGTGGCTCC AGTGCCCAGC 
AACCGCAAAG GAAATGGGGA CTATATGCCC ATGAGCCCCA AGAGTGTATC TGCCCCCCAG 
CAGATCATTA ACCCCATCAG GCGCCACCCA CAGAGAGTGG ACCCCAATGG CTACATGATG 
ATGTCTCCCA GTGGTAGTTG CTCTCCTGAC ATTGGAGGTG GGTCTTGCAG CAGTAGCAGC 
ATCAGCGCAG CCCCTTCTGG GAGCAGCTAT GGGAAGCCAT GGACAAACGG AGTAGGGGGG 
CACCATACCC ATGCCCTTCC CCATGCCAAA CCTCCTGTTG AGAGCGGTGG TGGTAAGCTC 
TTGCCTTGCA CTGGTGACTA CATGAACATG TCGCCAGTGG GAGATTCCAA CACCAGCAGC 
CCCTCAGAAT GCTACTATGG CCCAGAAGAT CCCCAGCACA AGCCTGTCCT CTCCTACTAC 
TCATTACCAA GGTCCTTTAA GCACACCCAG CGCCCTGGGG AGCCAGAGGA GGGTGCCAGG 
CACCAGCATC TTCGTCTCTC TTCAAGCTCT GGACGCCTTC GCTATACCGC AACTGCCGAA 
GATTCCTCCT CTTCCACCAG CAGCGACAGC CTGGGTGGGG GTTACTGTGG GGCTAGGCCA 
GAGTCTAGCG TCACACATCC CCACCACCAT GCCTTGCAGC CCCATCTGCC TCGAAAGGTA 
GACACAGCTG CACAGACCAA CAGCCGCCTG GCTCGACCCA CAAGGCTGTC CTTGGGGGAT 
CCCAAGGCAA GCACTTTACC CCGGGTACGA GAGCAACAGC AGCAGCAGCA ACAGCAGCAG 
CAGTCTTCCC TGCACCCTCC CGAGCCCAAA AGCCCAGGAG AATATGTGAA TATTGAATTC 
GGGAGTGGCC AGCCAGGCTA TTTAGCTGGC CCTGCAACTT CCCGTAGCTC CCCTTCAGTT 
CGATGTCTAC CCCAGCTCCA CCCAGCTCCC AGAGAAGAGA CTGGCTCGGA AGAGTACATG 
AACATGGACT TGGGGCCAGG CCGGAGGGCA ACCTGGCAGG AGAGTGGTGG AGTTGAGTTG 
GGCAGAGTAG GCCCTGCACC TCCAGGGGCT GCTTCCATTT GTAGGCCAAC CCGGTCGGTG 
CCAAATAGCC GTGGTGATTA CATGACCATG CAGATAGGTT GTCCTCGTCA AAGCTATGTG 
GATACCTCAC CAGTGGCCCC AGTCAGCTAT GCTGACATGC GGACAGGCAT TGCTGCAGAG 
AAGGTGAGCC TGCCCAGAAC CACAGGAGCT GCCCCCCCTC CATCCTCCAC AGCCTCTGCT 
TCTGCTTCTG TTACACCTCA AGGGGCCGCT GAGCAGGCCG CTCACTCTTC CTTGCTGGGA 
GGCCCTCAGG GACCTGGGGG CATGAGCGCA TTCACCAGGG TGAACCTAAG TCCCAACCAT 
AACCAGAGTG CCAAAGTGAT TCGTGCAGAC ACTCAAGGCT GCCGGAGGAG GCACAGCTCC 
GAGACCTTCT CGGCGCCTAC GCGGGCTGCC AACACAGTGT CTTTTGGAGC AGGGGCTGCA 
GGAGGGGGCA GCGGTGGTGG CAGTGAGGAT GTGAAACGCC ACAGCTCTGC ATCCTTTGAG 
AATGTGTGGC TGAGACCCGG GGATCTAGGG GGAGCATCCA AGGAGTCGGC TCCAGGGTGC 
GGGGCTGCCG GGGGATTGGA GAAGAGTCTT AACTATATAG ACTTGGATTT GGTCAAGGAT 
GTTAAGCAGC ACCCTCAAGA CTGCCCCTCT CAACAGCAGT CCCTGCCACC CCCTCCCCCT 
CACCAACCCT TAGGCAGCAA TGAGGGCAGC TCCCCAAGAC GCTCCAGTGA GGATTTAAGC 
ACCTATGCCA GCATCAACTT CCAGAAGCAA CCAGAGGACC GTCAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IRS-1 targets TAZ to inhibit adipogenesis of rat bone marrow mesenchymal stem cells through PI3K-Akt and MEK-ERK pathways.
European journal of pharmacology84911-21(2019 Apr)
Wang N,Li Y,Li Z,Ma J,Wu X,Pan R,Wang Y,Gao L,Bao X,Xue P

[miR-494-3p reduces insulin sensitivity in diabetic cardiomyocytes by down-regulation of insulin receptor substrate 1].
Sheng li xue bao : [Acta physiologica Sinica]71(2)271-278(2019 Apr)
Wu J,Qin XH,Hou ZX,Fu ZH,Li GH,Yang HY,Zhang X,Gao F

Polyphenol-rich ethyl acetate fraction isolated from Molineria latifolia ameliorates insulin resistance in experimental diabetic rats via IRS1/AKT activation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie98125-133(2018 Feb)
Ooi J,Adamu HA,Imam MU,Ithnin H,Ismail M

Tanshinone I alleviates insulin resistance in type 2 diabetes mellitus rats through IRS-1 pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie93352-358(2017 Sep)
Wei Y,Gao J,Qin L,Xu Y,Wang D,Shi H,Xu T,Liu T

The Insulin Receptor Plays a Critical Role in T Cell Function and Adaptive Immunity.
Journal of immunology (Baltimore, Md. : 1950)198(5)1910-1920(2017 03)
Fischer HJ,Sie C,Schumann E,Witte AK,Dressel R,van den Brandt J,Reichardt HM

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Irs1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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