Irs1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Irs1
Entrez Gene ID	16367
Full Name	insulin receptor substrate 1
Synonyms	G972R,IRS-1
General protein information	Preferred Names insulin receptor substrate 1 Names insulin receptor substrate 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 C5\|1 42.0 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010570.4	NP_034700.2	insulin receptor substrate 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Irs1	NP_037101.1
Gallus gallus (chicken)	IRS1	XP_004951158.1
Homo sapiens (human)	IRS1	NP_005535.1
Pan troglodytes (chimpanzee)	IRS1	XP_001134895.1
Xenopus tropicalis (tropical clawed frog)	LOC100495320	XP_004914519.1
Canis lupus familiaris (dog)	IRS1	XP_543274.3
Danio rerio (zebrafish)	irs1	XP_005157831.1
Bos taurus (cattle)	IRS1	XP_003585821.1
Mus musculus (house mouse)	Irs1	NP_034700.2

Gene Ontology
Bibliography

Related articles in PubMed

The Diurnal Rhythm of Insulin Receptor Substrate-1 (IRS-1) and Kir4.1 in Diabetes: Implications for a Clock Gene Bmal1.
Luo Q, Xiao Y, Alex A, Cummins TR, Bhatwadekar AD
Investigative ophthalmology & visual science60(6)1928-1936(2019 05)

Hyperglycemia induces vascular smooth muscle cell dedifferentiation by suppressing insulin receptor substrate-1-mediated p53/KLF4 complex stabilization.
Xi G, Shen X, Wai C, White MF, Clemmons DR
The Journal of biological chemistry294(7)2407-2421(2019 02)

Dioscin attenuates high‑fat diet‑induced insulin resistance of adipose tissue through the IRS‑1/PI3K/Akt signaling pathway.
Li H, Yu L, Zhao C
Molecular medicine reports19(2)1230-1237(2019 Feb)

TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression.
Hwang JH, Kim AR, Kim KM, Il Park J, Oh HT, Moon SA, Byun MR, Jeong H, Kim HK, Yaffe MB, Hwang ES, Hong JH
Nature communications10(1)421(2019 01)

Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver.
Kalvisa A, Siersbæk MS, Præstholm SM, Christensen LJL, Nielsen R, Stohr O, Vettorazzi S, Tuckermann J, White M, Mandrup S, Grøntved L
PLoS biology16(12)e2006249(2018 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Irs1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Irs1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21935	NM_010570.4 Latest version!	Mus musculus insulin receptor substrate 1 (Irs1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$643.30 $919.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Irs1 ( NM_010570.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034700.2 Mus musculus insulin receptor substrate 1 (Irs1), mRNA.

Price & Availability↑

CloneID	OMu21935
Clone ID Related Accession (Same CDS sequence)	NM_010570.4
Accession Version	NM_010570.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3696bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577289600000
Organism	Mus musculus(house mouse)
Product	insulin receptor substrate 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC137845.9 and AC123690.19. On Nov 27, 2007 this sequence version replaced NM_010570.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK045317.1, X69722.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164141 [ECO:0000348] ##Evidence-Data-END##

ATGGCGAGCC CTCCGGATAC CGATGGCTTC TCAGACGTGC GCAAGGTGGG CTACCTGCGC 
AAGCCCAAGA GTATGCATAA GCGCTTTTTC GTGCTGCGGG CGGCCAGCGA GGCCGGGGGC 
CCAGCGCGCC TGGAGTATTA TGAGAACGAG AAGAAGTGGC GGCACAAGTC GAGCGCCCCC 
AAACGCTCGA TCCCCCTCGA GAGCTGTTTC AACATCAACA AGCGGGCTGA CTCCAAGAAC 
AAGCACCTGG TGGCTCTCTA CACCCGAGAC GAACACTTTG CCATTGCCGC GGATAGCGAG 
GCTGAGCAAG ACAGCTGGTA CCAGGCTCTT CTGCAGCTGC ATAATCGGGC AAAGGCCCAC 
CATGACGGGG CTGGAGGAGG CTGCGGCGGT AGCTGCAGCG GCAGCTCTGG CGTTGGAGAG 
GCAGGGGAGG ACTTGAGCTA TGACACGGGT CCAGGACCCG CGTTCAAGGA GGTCTGGCAG 
GTTATCCTGA AACCCAAGGG CCTGGGTCAG ACAAAGAACC TGATTGGCAT CTACCGCCTC 
TGCCTGACCA GCAAGACCAT CAGCTTTGTG AAGCTGAACT CCGAGGCAGC CGCTGTGGTG 
CTGCAGCTGA TGAATATCAG ACGCTGTGGC CACTCAGAGA ACTTCTTCTT CATCGAGGTG 
GGGCGTTCCG CTGTGACAGG GCCTGGCGAG TTCTGGATGC AAGTGGATGA CTCCGTGGTG 
GCCCAGAACA TGCATGAGAC CATTCTAGAG GCAATGAGGG CCATGAGCGA TGAGTTTCGC 
CCTCGCAGCA AAAGCCAGTC TTCATCCAGT TGCTCCAACC CCATCAGCGT TCCCCTGCGC 
AGGCACCATC TCAACAACCC TCCACCCAGC CAGGTGGGAC TGACTCGGAG ATCTCGAACT 
GAGAGCATCA CTGCCACCTC CCCTGCCAGT ATGGTGGGTG GGAAACCAGG TTCCTTCCGG 
GTGCGTGCCT CCAGCGATGG CGAAGGCACC ATGTCCCGTC CAGCATCAGT GGATGGCAGT 
CCTGTGAGCC CTAGCACCAA CAGGACCCAC GCCCATCGGC ATCGAGGCAG CTCCAGGCTG 
CACCCCCCAC TCAACCACAG CCGCTCCATC CCCATGCCTT CTTCTAGATG CTCACCTTCA 
GCCACCAGCC CAGTGAGTCT GTCATCTAGT AGTACCAGTG GCCATGGCTC CACTTCAGAC 
TGTCTCTTCC CGAGGCGCTC TAGTGCTTCC GTGTCCGGTT CGCCTAGCGA TGGCGGTTTC 
ATCTCTTCTG ATGAGTATGG TTCTAGTCCC TGCGATTTCC GAAGTTCCTT CCGCAGTGTC 
ACCCCAGATT CCCTGGGGCA CACCCCACCA GCCAGGGGTG AGGAGGAGCT GAGCAATTAT 
ATCTGCATGG GTGGCAAGGG AGCCTCCACC TTGGCTGCTC CCAATGGCCA CTACATTTTG 
TCTAGGGGTG GCAACGGCCA TCGCTACATC CCAGGTGCTA ACTTGGGGAC AAGCCCAGCG 
CTGCCTGGAG ATGAAGCCGC GGGTGCAGCA GATCTGGATA ACCGGTTTCG AAAGAGAACT 
CACTCCGCAG GCACATCTCC TACCATTTCC CATCAGAAGA CCCCCTCACA GTCTTCAGTG 
GCTTCTATTG AGGAATATAC AGAGATGATG CCCGCTGCCT ACCCACCAGG AGGTGGCAGT 
GGAGGCCGAC TGCCCGGCTA CCGGCATTCC GCCTTCGTGC CCACCCACTC CTATCCCGAA 
GAGGGTCTAG AGATGCACCA CTTGGAACGT CGTGGAGGCC ACCACCGTCC AGACACCTCC 
AACCTCCACA CTGATGATGG CTATATGCCC ATGTCTCCTG GGGTGGCTCC AGTGCCCAGC 
AACCGCAAAG GAAATGGGGA CTATATGCCC ATGAGCCCCA AGAGTGTATC TGCCCCACAG 
CAGATCATTA ACCCCATCAG ACGCCACCCA CAGAGAGTGG ACCCCAATGG CTACATGATG 
ATGTCACCCA GTGGTAGTTG CTCCCCTGAC ATTGGAGGTG GGTCCAGCAG CAGTAGCAGC 
ATCAGCGCAG CCCCTTCTGG GAGCAGCTAT GGGAAGCCAT GGACAAATGG AGTAGGGGGG 
CACCATACTC ATGCCCTTCC TCATGCCAAA CCTCCTGTTG AGAGTGGTGG CGGTAAGCTC 
TTGCCTTGCA CAGGTGACTA CATGAACATG TCCCCAGTGG GAGATTCCAA CACCAGCAGC 
CCCTCAGAAT GCTACTATGG CCCAGAAGAT CCCCAGCACA AGCCGGTCCT CTCTTACTAC 
TCATTGCCAA GGTCCTTTAA GCACACCCAG CGCCCTGGAG AGCCAGAGGA GGGTGCCAGG 
CACCAGCATC TTCGTCTCTC TTCTAGCTCT GGACGCCTTC GCTATACCGC AACTGCCGAA 
GATTCCTCCT CTTCTACCAG CAGCGACAGT CTGGGTGGGG GTTACTGTGG GGCTAGGCCA 
GAGTCAAGCC TCACACATCC CCACCACCAT GTCTTGCAGC CCCACCTGCC TCGAAAGGTA 
GACACAGCTG CACAGACCAA CAGCCGCCTG GCTCGACCCA CAAGGCTGTC CTTGGGGGAT 
CCCAAGGCAA GCACCTTACC CCGGGTTCGA GAGCAGCAAC AGCAGCAGCA GTCTTCCCTG 
CACCCTCCCG AGCCCAAAAG CCCAGGAGAA TATGTGAATA TTGAATTCGG GAGCGGCCAG 
CCTGGCTATT TAGCTGGCCC TGCAACTTCC CGTAGCTCTC CTTCAGTTCG ATGTCCACCC 
CAGCTCCACC CAGCTCCTAG AGAAGAGACT GGCTCGGAAG AGTACATGAA CATGGACTTG 
GGGCCAGGCC GGAGGGCAAC CTGGCAGGAG AGTGGTGGAG TTGAGTTGGG CAGAATAGGC 
CCTGCACCTC CGGGGTCTGC TACGGTTTGC AGGCCAACCC GTTCGGTGCC AAATAGCCGT 
GGTGACTACA TGACCATGCA GATAGGTTGT CCTCGTCAAA GCTATGTGGA TACCTCACCA 
GTGGCCCCAG TCAGCTATGC TGACATGCGG ACAGGCATTG CTGCAGAGAA GGCGAGCCTG 
CCTAGACCCA CAGGAGCTGC TCCTCCTCCA TCCTCCACAG CCTCTTCTTC TGTTACACCT 
CAAGGAGCCA CCGCTGAGCA AGCTACTCAC TCTTCCTTGC TGGGAGGCCC TCAGGGACCT 
GGGGGCATGA GTGCATTCAC CAGGGTGAAC CTCAGTCCCA ACCATAACCA GAGTGCCAAA 
GTGATTCGCG CAGACACTCA AGGGTGCCGG AGGAGGCATA GCTCTGAGAC CTTCTCAGCA 
CCTACTCGGG CTGGCAATAC GGTGCCCTTT GGAGCAGGGG CTGCAGTAGG GGGCAGCGGC 
GGTGGTGGTG GTGGCGGCAG TGAGGATGTA AAACGCCACA GCTCTGCATC CTTTGAGAAT 
GTGTGGCTGA GACCTGGGGA TCTAGGGGGA GTCTCCAAGG AGTCGGCTCC AGTGTGTGGG 
GCTGCTGGGG GTTTGGAGAA GAGTCTTAAC TACATAGACC TGGATTTGGC CAAGGAGCGC 
TCTCAGGACT GCCCCTCTCA ACAGCAGTCC CTACCACCCC CTCCCCCTCA CCAGCCCTTA 
GGCAGCAATG AGGGCAACTC CCCAAGACGC TCCAGTGAGG ATTTAAGCAA CTATGCCAGC 
ATCAGCTTCC AGAAGCAGCC AGAGGATCGT CAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034700.2
CDS	947..4642
Translation	MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAHHDGAGGGCGGSCSGSSGVGEAGEDLSYDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLAAPNGHYILSRGGNGHRYIPGANLGTSPALPGDEAAGAADLDNRFRKRTHSAGTSPTISHQKTPSQSSVASIEEYTEMMPAAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDTSNLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGSCSPDIGGGSSSSSSISAAPSGSSYGKPWTNGVGGHHTHALPHAKPPVESGGGKLLPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSSSSGRLRYTATAEDSSSSTSSDSLGGGYCGARPESSLTHPHHHVLQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQSSLHPPEPKSPGEYVNIEFGSGQPGYLAGPATSRSSPSVRCPPQLHPAPREETGSEEYMNMDLGPGRRATWQESGGVELGRIGPAPPGSATVCRPTRSVPNSRGDYMTMQIGCPRQSYVDTSPVAPVSYADMRTGIAAEKASLPRPTGAAPPPSSTASSSVTPQGATAEQATHSSLLGGPQGPGGMSAFTRVNLSPNHNQSAKVIRADTQGCRRRHSSETFSAPTRAGNTVPFGAGAAVGGSGGGGGGGSEDVKRHSSASFENVWLRPGDLGGVSKESAPVCGAAGGLEKSLNYIDLDLAKERSQDCPSQQQSLPPPPPHQPLGSNEGNSPRRSSEDLSNYASISFQKQPEDRQ

Target ORF information:

RefSeq Version	NM_010570.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus insulin receptor substrate 1 (Irs1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010570.4

ORF Insert Sequence:

ATGGCGAGCC CTCCGGATAC CGATGGCTTC TCAGACGTGC GCAAGGTGGG CTACCTGCGC 
AAGCCCAAGA GTATGCATAA GCGCTTTTTC GTGCTGCGGG CGGCCAGCGA GGCCGGGGGC 
CCAGCGCGCC TGGAGTATTA TGAGAACGAG AAGAAGTGGC GGCACAAGTC GAGCGCCCCC 
AAACGCTCGA TCCCCCTCGA GAGCTGTTTC AACATCAACA AGCGGGCTGA CTCCAAGAAC 
AAGCACCTGG TGGCTCTCTA CACCCGAGAC GAACACTTTG CCATTGCCGC GGATAGCGAG 
GCTGAGCAAG ACAGCTGGTA CCAGGCTCTT CTGCAGCTGC ATAATCGGGC AAAGGCCCAC 
CATGACGGGG CTGGAGGAGG CTGCGGCGGT AGCTGCAGCG GCAGCTCTGG CGTTGGAGAG 
GCAGGGGAGG ACTTGAGCTA TGACACGGGT CCAGGACCCG CGTTCAAGGA GGTCTGGCAG 
GTTATCCTGA AACCCAAGGG CCTGGGTCAG ACAAAGAACC TGATTGGCAT CTACCGCCTC 
TGCCTGACCA GCAAGACCAT CAGCTTTGTG AAGCTGAACT CCGAGGCAGC CGCTGTGGTG 
CTGCAGCTGA TGAATATCAG ACGCTGTGGC CACTCAGAGA ACTTCTTCTT CATCGAGGTG 
GGGCGTTCCG CTGTGACAGG GCCTGGCGAG TTCTGGATGC AAGTGGATGA CTCCGTGGTG 
GCCCAGAACA TGCATGAGAC CATTCTAGAG GCAATGAGGG CCATGAGCGA TGAGTTTCGC 
CCTCGCAGCA AAAGCCAGTC TTCATCCAGT TGCTCCAACC CCATCAGCGT TCCCCTGCGC 
AGGCACCATC TCAACAACCC TCCACCCAGC CAGGTGGGAC TGACTCGGAG ATCTCGAACT 
GAGAGCATCA CTGCCACCTC CCCTGCCAGT ATGGTGGGTG GGAAACCAGG TTCCTTCCGG 
GTGCGTGCCT CCAGCGATGG CGAAGGCACC ATGTCCCGTC CAGCATCAGT GGATGGCAGT 
CCTGTGAGCC CTAGCACCAA CAGGACCCAC GCCCATCGGC ATCGAGGCAG CTCCAGGCTG 
CACCCCCCAC TCAACCACAG CCGCTCCATC CCCATGCCTT CTTCTAGATG CTCACCTTCA 
GCCACCAGCC CAGTGAGTCT GTCATCTAGT AGTACCAGTG GCCATGGCTC CACTTCAGAC 
TGTCTCTTCC CGAGGCGCTC TAGTGCTTCC GTGTCCGGTT CGCCTAGCGA TGGCGGTTTC 
ATCTCTTCTG ATGAGTATGG TTCTAGTCCC TGCGATTTCC GAAGTTCCTT CCGCAGTGTC 
ACCCCAGATT CCCTGGGGCA CACCCCACCA GCCAGGGGTG AGGAGGAGCT GAGCAATTAT 
ATCTGCATGG GTGGCAAGGG AGCCTCCACC TTGGCTGCTC CCAATGGCCA CTACATTTTG 
TCTAGGGGTG GCAACGGCCA TCGCTACATC CCAGGTGCTA ACTTGGGGAC AAGCCCAGCG 
CTGCCTGGAG ATGAAGCCGC GGGTGCAGCA GATCTGGATA ACCGGTTTCG AAAGAGAACT 
CACTCCGCAG GCACATCTCC TACCATTTCC CATCAGAAGA CCCCCTCACA GTCTTCAGTG 
GCTTCTATTG AGGAATATAC AGAGATGATG CCCGCTGCCT ACCCACCAGG AGGTGGCAGT 
GGAGGCCGAC TGCCCGGCTA CCGGCATTCC GCCTTCGTGC CCACCCACTC CTATCCCGAA 
GAGGGTCTAG AGATGCACCA CTTGGAACGT CGTGGAGGCC ACCACCGTCC AGACACCTCC 
AACCTCCACA CTGATGATGG CTATATGCCC ATGTCTCCTG GGGTGGCTCC AGTGCCCAGC 
AACCGCAAAG GAAATGGGGA CTATATGCCC ATGAGCCCCA AGAGTGTATC TGCCCCACAG 
CAGATCATTA ACCCCATCAG ACGCCACCCA CAGAGAGTGG ACCCCAATGG CTACATGATG 
ATGTCACCCA GTGGTAGTTG CTCCCCTGAC ATTGGAGGTG GGTCCAGCAG CAGTAGCAGC 
ATCAGCGCAG CCCCTTCTGG GAGCAGCTAT GGGAAGCCAT GGACAAATGG AGTAGGGGGG 
CACCATACTC ATGCCCTTCC TCATGCCAAA CCTCCTGTTG AGAGTGGTGG CGGTAAGCTC 
TTGCCTTGCA CAGGTGACTA CATGAACATG TCCCCAGTGG GAGATTCCAA CACCAGCAGC 
CCCTCAGAAT GCTACTATGG CCCAGAAGAT CCCCAGCACA AGCCGGTCCT CTCTTACTAC 
TCATTGCCAA GGTCCTTTAA GCACACCCAG CGCCCTGGAG AGCCAGAGGA GGGTGCCAGG 
CACCAGCATC TTCGTCTCTC TTCTAGCTCT GGACGCCTTC GCTATACCGC AACTGCCGAA 
GATTCCTCCT CTTCTACCAG CAGCGACAGT CTGGGTGGGG GTTACTGTGG GGCTAGGCCA 
GAGTCAAGCC TCACACATCC CCACCACCAT GTCTTGCAGC CCCACCTGCC TCGAAAGGTA 
GACACAGCTG CACAGACCAA CAGCCGCCTG GCTCGACCCA CAAGGCTGTC CTTGGGGGAT 
CCCAAGGCAA GCACCTTACC CCGGGTTCGA GAGCAGCAAC AGCAGCAGCA GTCTTCCCTG 
CACCCTCCCG AGCCCAAAAG CCCAGGAGAA TATGTGAATA TTGAATTCGG GAGCGGCCAG 
CCTGGCTATT TAGCTGGCCC TGCAACTTCC CGTAGCTCTC CTTCAGTTCG ATGTCCACCC 
CAGCTCCACC CAGCTCCTAG AGAAGAGACT GGCTCGGAAG AGTACATGAA CATGGACTTG 
GGGCCAGGCC GGAGGGCAAC CTGGCAGGAG AGTGGTGGAG TTGAGTTGGG CAGAATAGGC 
CCTGCACCTC CGGGGTCTGC TACGGTTTGC AGGCCAACCC GTTCGGTGCC AAATAGCCGT 
GGTGACTACA TGACCATGCA GATAGGTTGT CCTCGTCAAA GCTATGTGGA TACCTCACCA 
GTGGCCCCAG TCAGCTATGC TGACATGCGG ACAGGCATTG CTGCAGAGAA GGCGAGCCTG 
CCTAGACCCA CAGGAGCTGC TCCTCCTCCA TCCTCCACAG CCTCTTCTTC TGTTACACCT 
CAAGGAGCCA CCGCTGAGCA AGCTACTCAC TCTTCCTTGC TGGGAGGCCC TCAGGGACCT 
GGGGGCATGA GTGCATTCAC CAGGGTGAAC CTCAGTCCCA ACCATAACCA GAGTGCCAAA 
GTGATTCGCG CAGACACTCA AGGGTGCCGG AGGAGGCATA GCTCTGAGAC CTTCTCAGCA 
CCTACTCGGG CTGGCAATAC GGTGCCCTTT GGAGCAGGGG CTGCAGTAGG GGGCAGCGGC 
GGTGGTGGTG GTGGCGGCAG TGAGGATGTA AAACGCCACA GCTCTGCATC CTTTGAGAAT 
GTGTGGCTGA GACCTGGGGA TCTAGGGGGA GTCTCCAAGG AGTCGGCTCC AGTGTGTGGG 
GCTGCTGGGG GTTTGGAGAA GAGTCTTAAC TACATAGACC TGGATTTGGC CAAGGAGCGC 
TCTCAGGACT GCCCCTCTCA ACAGCAGTCC CTACCACCCC CTCCCCCTCA CCAGCCCTTA 
GGCAGCAATG AGGGCAACTC CCCAAGACGC TCCAGTGAGG ATTTAAGCAA CTATGCCAGC 
ATCAGCTTCC AGAAGCAGCC AGAGGATCGT CAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Diurnal Rhythm of Insulin Receptor Substrate-1 (IRS-1) and Kir4.1 in Diabetes: Implications for a Clock Gene Bmal1.
Investigative ophthalmology & visual science60(6)1928-1936(2019 05)
Luo Q,Xiao Y,Alex A,Cummins TR,Bhatwadekar AD

Hyperglycemia induces vascular smooth muscle cell dedifferentiation by suppressing insulin receptor substrate-1-mediated p53/KLF4 complex stabilization.
The Journal of biological chemistry294(7)2407-2421(2019 02)
Xi G,Shen X,Wai C,White MF,Clemmons DR

Dioscin attenuates high‑fat diet‑induced insulin resistance of adipose tissue through the IRS‑1/PI3K/Akt signaling pathway.
Molecular medicine reports19(2)1230-1237(2019 Feb)
Li H,Yu L,Zhao C

TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression.
Nature communications10(1)421(2019 01)
Hwang JH,Kim AR,Kim KM,Il Park J,Oh HT,Moon SA,Byun MR,Jeong H,Kim HK,Yaffe MB,Hwang ES,Hong JH

Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver.
PLoS biology16(12)e2006249(2018 12)
Kalvisa A,Siersbæk MS,Præstholm SM,Christensen LJL,Nielsen R,Stohr O,Vettorazzi S,Tuckermann J,White M,Mandrup S,Grøntved L

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Irs1 cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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