ITGB3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ITGB3
Entrez Gene ID	3690
Full Name	integrin subunit beta 3
Synonyms	BDPLT16,BDPLT2,CD61,GP3A,GPIIIa,GT
General protein information	Preferred Names integrin subunit beta 3 Names integrin beta-3 antigen CD61 integrin beta 3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) platelet membrane glycoprotein IIIa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.32
Summary	The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008].
Disorder MIM:	173470
Disorder Html:	Glanzmann thrombasthenia, 273800 (3); Thrombocytopenia, neonatal alloimmune (3); {Myocardial infarction, susceptibility to}, 608446 (3); Purpura, posttransfusion (3); Bleeding disorder, platelet-type, 16, autosomal dominant, 187800 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000212.2	NP_000203.2	integrin beta-3 precursor
NM_000212.3	NP_000203.2	integrin beta-3 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ITGB3	XP_523684.2
Mus musculus (house mouse)	Itgb3	NP_058060.2
Homo sapiens (human)	ITGB3	NP_000203.2
Macaca mulatta (Rhesus monkey)	ITGB3	XP_001116013.1
Bos taurus (cattle)	ITGB3	NP_001193419.1
Xenopus tropicalis (tropical clawed frog)	itgb3	XP_002942401.2
Canis lupus familiaris (dog)	ITGB3	NP_001003162.1
Rattus norvegicus (Norway rat)	Itgb3	NP_714942.1
Gallus gallus (chicken)	ITGB3	NP_989646.1
Danio rerio (zebrafish)	itgb3b	NP_001076417.1

Gene Ontology
Bibliography

Related articles in PubMed

Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.
Nakamura K, Ikeuchi T, Nara K, Rhodes CS, Zhang P, Chiba Y, Kazuno S, Miura Y, Ago T, Arikawa-Hirasawa E, Mukouyama YS, Yamada Y
The Journal of cell biology218(10)3506-3525(2019 Oct)

Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling.
Takada YK, Yu J, Shimoda M, Takada Y
Journal of immunology (Baltimore, Md. : 1950)203(5)1383-1391(2019 Sep)

The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke.
Yi X, Lin J, Zhou Q, Huang R, Chai Z
BMC neurology19(1)44(2019 Mar)

Nuclear lncRNA HOXD-AS1 suppresses colorectal carcinoma growth and metastasis via inhibiting HOXD3-induced integrin β3 transcriptional activating and MAPK/AKT signalling.
Yang MH, Zhao L, Wang L, Ou-Yang W, Hu SS, Li WL, Ai ML, Wang YQ, Han Y, Li TT, Ding YQ, Wang S
Molecular cancer18(1)31(2019 03)

A Single-Nucleotide Polymorphism of α
Martínez-Valdebenito C, Angulo J, Le Corre N, Marco C, Vial C, Miquel JF, Cerda J, Mertz G, Vial P, Lopez-Lastra M, Ferrés M
Viruses11(2)(2019 02)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ITGB3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ITGB3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18083	NM_000212.3 Latest version!	Homo sapiens integrin subunit beta 3 (ITGB3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu18083	NM_000212.2	Homo sapiens integrin subunit beta 3 (ITGB3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ITGB3 ( NM_000212.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000203.2 Homo sapiens integrin subunit beta 3 (ITGB3), mRNA.

Price & Availability↑

CloneID	OHu18083
Clone ID Related Accession (Same CDS sequence)	NM_000212.2 , NM_000212.3
Accession Version	NM_000212.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2367bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1560700800000
Organism	Homo sapiens(human)
Product	integrin beta-3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from J02703.1, M20311.1, M35999.1, BE389074.1, BQ437000.1, BG170864.1 and BE893993.1. This sequence is a reference standard in the RefSeqGene project. On May 7, 2004 this sequence version replaced NM_000212.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J02703.1, SRR1660805.226381.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCGAGCGC GGCCGCGGCC CCGGCCGCTC TGGGCGACTG TGCTGGCGCT GGGGGCGCTG 
GCGGGCGTTG GCGTAGGAGG GCCCAACATC TGTACCACGC GAGGTGTGAG CTCCTGCCAG 
CAGTGCCTGG CTGTGAGCCC CATGTGTGCC TGGTGCTCTG ATGAGGCCCT GCCTCTGGGC 
TCACCTCGCT GTGACCTGAA GGAGAATCTG CTGAAGGATA ACTGTGCCCC AGAATCCATC 
GAGTTCCCAG TGAGTGAGGC CCGAGTACTA GAGGACAGGC CCCTCAGCGA CAAGGGCTCT 
GGAGACAGCT CCCAGGTCAC TCAAGTCAGT CCCCAGAGGA TTGCACTCCG GCTCCGGCCA 
GATGATTCGA AGAATTTCTC CATCCAAGTG CGGCAGGTGG AGGATTACCC TGTGGACATC 
TACTACTTGA TGGACCTGTC TTACTCCATG AAGGATGATC TGTGGAGCAT CCAGAACCTG 
GGTACCAAGC TGGCCACCCA GATGCGAAAG CTCACCAGTA ACCTGCGGAT TGGCTTCGGG 
GCATTTGTGG ACAAGCCTGT GTCACCATAC ATGTATATCT CCCCACCAGA GGCCCTCGAA 
AACCCCTGCT ATGATATGAA GACCACCTGC TTGCCCATGT TTGGCTACAA ACACGTGCTG 
ACGCTAACTG ACCAGGTGAC CCGCTTCAAT GAGGAAGTGA AGAAGCAGAG TGTGTCACGG 
AACCGAGATG CCCCAGAGGG TGGCTTTGAT GCCATCATGC AGGCTACAGT CTGTGATGAA 
AAGATTGGCT GGAGGAATGA TGCATCCCAC TTGCTGGTGT TTACCACTGA TGCCAAGACT 
CATATAGCAT TGGACGGAAG GCTGGCAGGC ATTGTCCAGC CTAATGACGG GCAGTGTCAT 
GTTGGTAGTG ACAATCATTA CTCTGCCTCC ACTACCATGG ATTATCCCTC TTTGGGGCTG 
ATGACTGAGA AGCTATCCCA GAAAAACATC AATTTGATCT TTGCAGTGAC TGAAAATGTA 
GTCAATCTCT ATCAGAACTA TAGTGAGCTC ATCCCAGGGA CCACAGTTGG GGTTCTGTCC 
ATGGATTCCA GCAATGTCCT CCAGCTCATT GTTGATGCTT ATGGGAAAAT CCGTTCTAAA 
GTAGAGCTGG AAGTGCGTGA CCTCCCTGAA GAGTTGTCTC TATCCTTCAA TGCCACCTGC 
CTCAACAATG AGGTCATCCC TGGCCTCAAG TCTTGTATGG GACTCAAGAT TGGAGACACG 
GTGAGCTTCA GCATTGAGGC CAAGGTGCGA GGCTGTCCCC AGGAGAAGGA GAAGTCCTTT 
ACCATAAAGC CCGTGGGCTT CAAGGACAGC CTGATCGTCC AGGTCACCTT TGATTGTGAC 
TGTGCCTGCC AGGCCCAAGC TGAACCTAAT AGCCATCGCT GCAACAATGG CAATGGGACC 
TTTGAGTGTG GGGTATGCCG TTGTGGGCCT GGCTGGCTGG GATCCCAGTG TGAGTGCTCA 
GAGGAGGACT ATCGCCCTTC CCAGCAGGAC GAATGCAGCC CCCGGGAGGG TCAGCCCGTC 
TGCAGCCAGC GGGGCGAGTG CCTCTGTGGT CAATGTGTCT GCCACAGCAG TGACTTTGGC 
AAGATCACGG GCAAGTACTG CGAGTGTGAC GACTTCTCCT GTGTCCGCTA CAAGGGGGAG 
ATGTGCTCAG GCCATGGCCA GTGCAGCTGT GGGGACTGCC TGTGTGACTC CGACTGGACC 
GGCTACTACT GCAACTGTAC CACGCGTACT GACACCTGCA TGTCCAGCAA TGGGCTGCTG 
TGCAGCGGCC GCGGCAAGTG TGAATGTGGC AGCTGTGTCT GTATCCAGCC GGGCTCCTAT 
GGGGACACCT GTGAGAAGTG CCCCACCTGC CCAGATGCCT GCACCTTTAA GAAAGAATGT 
GTGGAGTGTA AGAAGTTTGA CCGGGGAGCC CTACATGACG AAAATACCTG CAACCGTTAC 
TGCCGTGACG AGATTGAGTC AGTGAAAGAG CTTAAGGACA CTGGCAAGGA TGCAGTGAAT 
TGTACCTATA AGAATGAGGA TGACTGTGTC GTCAGATTCC AGTACTATGA AGATTCTAGT 
GGAAAGTCCA TCCTGTATGT GGTAGAAGAG CCAGAGTGTC CCAAGGGCCC TGACATCCTG 
GTGGTCCTGC TCTCAGTGAT GGGGGCCATT CTGCTCATTG GCCTTGCCGC CCTGCTCATC 
TGGAAACTCC TCATCACCAT CCACGACCGA AAAGAATTCG CTAAATTTGA GGAAGAACGC 
GCCAGAGCAA AATGGGACAC AGCCAACAAC CCACTGTATA AAGAGGCCAC GTCTACCTTC 
ACCAATATCA CGTACCGGGG CACTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000203.2
CDS	21..2387
Translation	MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT

Target ORF information:

RefSeq Version	NM_000212.2
Organism	Homo sapiens(human)
Definition	Homo sapiens integrin subunit beta 3 (ITGB3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000212.2

ORF Insert Sequence:

ATGCGAGCGC GGCCGCGGCC CCGGCCGCTC TGGGCGACTG TGCTGGCGCT GGGGGCGCTG 
GCGGGCGTTG GCGTAGGAGG GCCCAACATC TGTACCACGC GAGGTGTGAG CTCCTGCCAG 
CAGTGCCTGG CTGTGAGCCC CATGTGTGCC TGGTGCTCTG ATGAGGCCCT GCCTCTGGGC 
TCACCTCGCT GTGACCTGAA GGAGAATCTG CTGAAGGATA ACTGTGCCCC AGAATCCATC 
GAGTTCCCAG TGAGTGAGGC CCGAGTACTA GAGGACAGGC CCCTCAGCGA CAAGGGCTCT 
GGAGACAGCT CCCAGGTCAC TCAAGTCAGT CCCCAGAGGA TTGCACTCCG GCTCCGGCCA 
GATGATTCGA AGAATTTCTC CATCCAAGTG CGGCAGGTGG AGGATTACCC TGTGGACATC 
TACTACTTGA TGGACCTGTC TTACTCCATG AAGGATGATC TGTGGAGCAT CCAGAACCTG 
GGTACCAAGC TGGCCACCCA GATGCGAAAG CTCACCAGTA ACCTGCGGAT TGGCTTCGGG 
GCATTTGTGG ACAAGCCTGT GTCACCATAC ATGTATATCT CCCCACCAGA GGCCCTCGAA 
AACCCCTGCT ATGATATGAA GACCACCTGC TTGCCCATGT TTGGCTACAA ACACGTGCTG 
ACGCTAACTG ACCAGGTGAC CCGCTTCAAT GAGGAAGTGA AGAAGCAGAG TGTGTCACGG 
AACCGAGATG CCCCAGAGGG TGGCTTTGAT GCCATCATGC AGGCTACAGT CTGTGATGAA 
AAGATTGGCT GGAGGAATGA TGCATCCCAC TTGCTGGTGT TTACCACTGA TGCCAAGACT 
CATATAGCAT TGGACGGAAG GCTGGCAGGC ATTGTCCAGC CTAATGACGG GCAGTGTCAT 
GTTGGTAGTG ACAATCATTA CTCTGCCTCC ACTACCATGG ATTATCCCTC TTTGGGGCTG 
ATGACTGAGA AGCTATCCCA GAAAAACATC AATTTGATCT TTGCAGTGAC TGAAAATGTA 
GTCAATCTCT ATCAGAACTA TAGTGAGCTC ATCCCAGGGA CCACAGTTGG GGTTCTGTCC 
ATGGATTCCA GCAATGTCCT CCAGCTCATT GTTGATGCTT ATGGGAAAAT CCGTTCTAAA 
GTAGAGCTGG AAGTGCGTGA CCTCCCTGAA GAGTTGTCTC TATCCTTCAA TGCCACCTGC 
CTCAACAATG AGGTCATCCC TGGCCTCAAG TCTTGTATGG GACTCAAGAT TGGAGACACG 
GTGAGCTTCA GCATTGAGGC CAAGGTGCGA GGCTGTCCCC AGGAGAAGGA GAAGTCCTTT 
ACCATAAAGC CCGTGGGCTT CAAGGACAGC CTGATCGTCC AGGTCACCTT TGATTGTGAC 
TGTGCCTGCC AGGCCCAAGC TGAACCTAAT AGCCATCGCT GCAACAATGG CAATGGGACC 
TTTGAGTGTG GGGTATGCCG TTGTGGGCCT GGCTGGCTGG GATCCCAGTG TGAGTGCTCA 
GAGGAGGACT ATCGCCCTTC CCAGCAGGAC GAATGCAGCC CCCGGGAGGG TCAGCCCGTC 
TGCAGCCAGC GGGGCGAGTG CCTCTGTGGT CAATGTGTCT GCCACAGCAG TGACTTTGGC 
AAGATCACGG GCAAGTACTG CGAGTGTGAC GACTTCTCCT GTGTCCGCTA CAAGGGGGAG 
ATGTGCTCAG GCCATGGCCA GTGCAGCTGT GGGGACTGCC TGTGTGACTC CGACTGGACC 
GGCTACTACT GCAACTGTAC CACGCGTACT GACACCTGCA TGTCCAGCAA TGGGCTGCTG 
TGCAGCGGCC GCGGCAAGTG TGAATGTGGC AGCTGTGTCT GTATCCAGCC GGGCTCCTAT 
GGGGACACCT GTGAGAAGTG CCCCACCTGC CCAGATGCCT GCACCTTTAA GAAAGAATGT 
GTGGAGTGTA AGAAGTTTGA CCGGGGAGCC CTACATGACG AAAATACCTG CAACCGTTAC 
TGCCGTGACG AGATTGAGTC AGTGAAAGAG CTTAAGGACA CTGGCAAGGA TGCAGTGAAT 
TGTACCTATA AGAATGAGGA TGACTGTGTC GTCAGATTCC AGTACTATGA AGATTCTAGT 
GGAAAGTCCA TCCTGTATGT GGTAGAAGAG CCAGAGTGTC CCAAGGGCCC TGACATCCTG 
GTGGTCCTGC TCTCAGTGAT GGGGGCCATT CTGCTCATTG GCCTTGCCGC CCTGCTCATC 
TGGAAACTCC TCATCACCAT CCACGACCGA AAAGAATTCG CTAAATTTGA GGAAGAACGC 
GCCAGAGCAA AATGGGACAC AGCCAACAAC CCACTGTATA AAGAGGCCAC GTCTACCTTC 
ACCAATATCA CGTACCGGGG CACTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ITGB3 ( NM_000212.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000203.2 Homo sapiens integrin subunit beta 3 (ITGB3), mRNA.

Price & Availability↑

CloneID	OHu18083
Clone ID Related Accession (Same CDS sequence)	NM_000212.2 , NM_000212.3
Accession Version	NM_000212.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2367bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1576684800000
Organism	Homo sapiens(human)
Product	integrin beta-3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC068234.8 and M35999.1. On Nov 25, 2019 this sequence version replaced NM_000212.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M35999.1, M20311.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCGAGCGC GGCCGCGGCC CCGGCCGCTC TGGGCGACTG TGCTGGCGCT GGGGGCGCTG 
GCGGGCGTTG GCGTAGGAGG GCCCAACATC TGTACCACGC GAGGTGTGAG CTCCTGCCAG 
CAGTGCCTGG CTGTGAGCCC CATGTGTGCC TGGTGCTCTG ATGAGGCCCT GCCTCTGGGC 
TCACCTCGCT GTGACCTGAA GGAGAATCTG CTGAAGGATA ACTGTGCCCC AGAATCCATC 
GAGTTCCCAG TGAGTGAGGC CCGAGTACTA GAGGACAGGC CCCTCAGCGA CAAGGGCTCT 
GGAGACAGCT CCCAGGTCAC TCAAGTCAGT CCCCAGAGGA TTGCACTCCG GCTCCGGCCA 
GATGATTCGA AGAATTTCTC CATCCAAGTG CGGCAGGTGG AGGATTACCC TGTGGACATC 
TACTACTTGA TGGACCTGTC TTACTCCATG AAGGATGATC TGTGGAGCAT CCAGAACCTG 
GGTACCAAGC TGGCCACCCA GATGCGAAAG CTCACCAGTA ACCTGCGGAT TGGCTTCGGG 
GCATTTGTGG ACAAGCCTGT GTCACCATAC ATGTATATCT CCCCACCAGA GGCCCTCGAA 
AACCCCTGCT ATGATATGAA GACCACCTGC TTGCCCATGT TTGGCTACAA ACACGTGCTG 
ACGCTAACTG ACCAGGTGAC CCGCTTCAAT GAGGAAGTGA AGAAGCAGAG TGTGTCACGG 
AACCGAGATG CCCCAGAGGG TGGCTTTGAT GCCATCATGC AGGCTACAGT CTGTGATGAA 
AAGATTGGCT GGAGGAATGA TGCATCCCAC TTGCTGGTGT TTACCACTGA TGCCAAGACT 
CATATAGCAT TGGACGGAAG GCTGGCAGGC ATTGTCCAGC CTAATGACGG GCAGTGTCAT 
GTTGGTAGTG ACAATCATTA CTCTGCCTCC ACTACCATGG ATTATCCCTC TTTGGGGCTG 
ATGACTGAGA AGCTATCCCA GAAAAACATC AATTTGATCT TTGCAGTGAC TGAAAATGTA 
GTCAATCTCT ATCAGAACTA TAGTGAGCTC ATCCCAGGGA CCACAGTTGG GGTTCTGTCC 
ATGGATTCCA GCAATGTCCT CCAGCTCATT GTTGATGCTT ATGGGAAAAT CCGTTCTAAA 
GTAGAGCTGG AAGTGCGTGA CCTCCCTGAA GAGTTGTCTC TATCCTTCAA TGCCACCTGC 
CTCAACAATG AGGTCATCCC TGGCCTCAAG TCTTGTATGG GACTCAAGAT TGGAGACACG 
GTGAGCTTCA GCATTGAGGC CAAGGTGCGA GGCTGTCCCC AGGAGAAGGA GAAGTCCTTT 
ACCATAAAGC CCGTGGGCTT CAAGGACAGC CTGATCGTCC AGGTCACCTT TGATTGTGAC 
TGTGCCTGCC AGGCCCAAGC TGAACCTAAT AGCCATCGCT GCAACAATGG CAATGGGACC 
TTTGAGTGTG GGGTATGCCG TTGTGGGCCT GGCTGGCTGG GATCCCAGTG TGAGTGCTCA 
GAGGAGGACT ATCGCCCTTC CCAGCAGGAC GAATGCAGCC CCCGGGAGGG TCAGCCCGTC 
TGCAGCCAGC GGGGCGAGTG CCTCTGTGGT CAATGTGTCT GCCACAGCAG TGACTTTGGC 
AAGATCACGG GCAAGTACTG CGAGTGTGAC GACTTCTCCT GTGTCCGCTA CAAGGGGGAG 
ATGTGCTCAG GCCATGGCCA GTGCAGCTGT GGGGACTGCC TGTGTGACTC CGACTGGACC 
GGCTACTACT GCAACTGTAC CACGCGTACT GACACCTGCA TGTCCAGCAA TGGGCTGCTG 
TGCAGCGGCC GCGGCAAGTG TGAATGTGGC AGCTGTGTCT GTATCCAGCC GGGCTCCTAT 
GGGGACACCT GTGAGAAGTG CCCCACCTGC CCAGATGCCT GCACCTTTAA GAAAGAATGT 
GTGGAGTGTA AGAAGTTTGA CCGGGGAGCC CTACATGACG AAAATACCTG CAACCGTTAC 
TGCCGTGACG AGATTGAGTC AGTGAAAGAG CTTAAGGACA CTGGCAAGGA TGCAGTGAAT 
TGTACCTATA AGAATGAGGA TGACTGTGTC GTCAGATTCC AGTACTATGA AGATTCTAGT 
GGAAAGTCCA TCCTGTATGT GGTAGAAGAG CCAGAGTGTC CCAAGGGCCC TGACATCCTG 
GTGGTCCTGC TCTCAGTGAT GGGGGCCATT CTGCTCATTG GCCTTGCCGC CCTGCTCATC 
TGGAAACTCC TCATCACCAT CCACGACCGA AAAGAATTCG CTAAATTTGA GGAAGAACGC 
GCCAGAGCAA AATGGGACAC AGCCAACAAC CCACTGTATA AAGAGGCCAC GTCTACCTTC 
ACCAATATCA CGTACCGGGG CACTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000203.2
CDS	36..2402
Translation	MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT

Target ORF information:

RefSeq Version	NM_000212.3
Organism	Homo sapiens(human)
Definition	Homo sapiens integrin subunit beta 3 (ITGB3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000212.3

ORF Insert Sequence:

ATGCGAGCGC GGCCGCGGCC CCGGCCGCTC TGGGCGACTG TGCTGGCGCT GGGGGCGCTG 
GCGGGCGTTG GCGTAGGAGG GCCCAACATC TGTACCACGC GAGGTGTGAG CTCCTGCCAG 
CAGTGCCTGG CTGTGAGCCC CATGTGTGCC TGGTGCTCTG ATGAGGCCCT GCCTCTGGGC 
TCACCTCGCT GTGACCTGAA GGAGAATCTG CTGAAGGATA ACTGTGCCCC AGAATCCATC 
GAGTTCCCAG TGAGTGAGGC CCGAGTACTA GAGGACAGGC CCCTCAGCGA CAAGGGCTCT 
GGAGACAGCT CCCAGGTCAC TCAAGTCAGT CCCCAGAGGA TTGCACTCCG GCTCCGGCCA 
GATGATTCGA AGAATTTCTC CATCCAAGTG CGGCAGGTGG AGGATTACCC TGTGGACATC 
TACTACTTGA TGGACCTGTC TTACTCCATG AAGGATGATC TGTGGAGCAT CCAGAACCTG 
GGTACCAAGC TGGCCACCCA GATGCGAAAG CTCACCAGTA ACCTGCGGAT TGGCTTCGGG 
GCATTTGTGG ACAAGCCTGT GTCACCATAC ATGTATATCT CCCCACCAGA GGCCCTCGAA 
AACCCCTGCT ATGATATGAA GACCACCTGC TTGCCCATGT TTGGCTACAA ACACGTGCTG 
ACGCTAACTG ACCAGGTGAC CCGCTTCAAT GAGGAAGTGA AGAAGCAGAG TGTGTCACGG 
AACCGAGATG CCCCAGAGGG TGGCTTTGAT GCCATCATGC AGGCTACAGT CTGTGATGAA 
AAGATTGGCT GGAGGAATGA TGCATCCCAC TTGCTGGTGT TTACCACTGA TGCCAAGACT 
CATATAGCAT TGGACGGAAG GCTGGCAGGC ATTGTCCAGC CTAATGACGG GCAGTGTCAT 
GTTGGTAGTG ACAATCATTA CTCTGCCTCC ACTACCATGG ATTATCCCTC TTTGGGGCTG 
ATGACTGAGA AGCTATCCCA GAAAAACATC AATTTGATCT TTGCAGTGAC TGAAAATGTA 
GTCAATCTCT ATCAGAACTA TAGTGAGCTC ATCCCAGGGA CCACAGTTGG GGTTCTGTCC 
ATGGATTCCA GCAATGTCCT CCAGCTCATT GTTGATGCTT ATGGGAAAAT CCGTTCTAAA 
GTAGAGCTGG AAGTGCGTGA CCTCCCTGAA GAGTTGTCTC TATCCTTCAA TGCCACCTGC 
CTCAACAATG AGGTCATCCC TGGCCTCAAG TCTTGTATGG GACTCAAGAT TGGAGACACG 
GTGAGCTTCA GCATTGAGGC CAAGGTGCGA GGCTGTCCCC AGGAGAAGGA GAAGTCCTTT 
ACCATAAAGC CCGTGGGCTT CAAGGACAGC CTGATCGTCC AGGTCACCTT TGATTGTGAC 
TGTGCCTGCC AGGCCCAAGC TGAACCTAAT AGCCATCGCT GCAACAATGG CAATGGGACC 
TTTGAGTGTG GGGTATGCCG TTGTGGGCCT GGCTGGCTGG GATCCCAGTG TGAGTGCTCA 
GAGGAGGACT ATCGCCCTTC CCAGCAGGAC GAATGCAGCC CCCGGGAGGG TCAGCCCGTC 
TGCAGCCAGC GGGGCGAGTG CCTCTGTGGT CAATGTGTCT GCCACAGCAG TGACTTTGGC 
AAGATCACGG GCAAGTACTG CGAGTGTGAC GACTTCTCCT GTGTCCGCTA CAAGGGGGAG 
ATGTGCTCAG GCCATGGCCA GTGCAGCTGT GGGGACTGCC TGTGTGACTC CGACTGGACC 
GGCTACTACT GCAACTGTAC CACGCGTACT GACACCTGCA TGTCCAGCAA TGGGCTGCTG 
TGCAGCGGCC GCGGCAAGTG TGAATGTGGC AGCTGTGTCT GTATCCAGCC GGGCTCCTAT 
GGGGACACCT GTGAGAAGTG CCCCACCTGC CCAGATGCCT GCACCTTTAA GAAAGAATGT 
GTGGAGTGTA AGAAGTTTGA CCGGGGAGCC CTACATGACG AAAATACCTG CAACCGTTAC 
TGCCGTGACG AGATTGAGTC AGTGAAAGAG CTTAAGGACA CTGGCAAGGA TGCAGTGAAT 
TGTACCTATA AGAATGAGGA TGACTGTGTC GTCAGATTCC AGTACTATGA AGATTCTAGT 
GGAAAGTCCA TCCTGTATGT GGTAGAAGAG CCAGAGTGTC CCAAGGGCCC TGACATCCTG 
GTGGTCCTGC TCTCAGTGAT GGGGGCCATT CTGCTCATTG GCCTTGCCGC CCTGCTCATC 
TGGAAACTCC TCATCACCAT CCACGACCGA AAAGAATTCG CTAAATTTGA GGAAGAACGC 
GCCAGAGCAA AATGGGACAC AGCCAACAAC CCACTGTATA AAGAGGCCAC GTCTACCTTC 
ACCAATATCA CGTACCGGGG CACTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.
The Journal of cell biology218(10)3506-3525(2019 Oct)
Nakamura K,Ikeuchi T,Nara K,Rhodes CS,Zhang P,Chiba Y,Kazuno S,Miura Y,Ago T,Arikawa-Hirasawa E,Mukouyama YS,Yamada Y

Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling.
Journal of immunology (Baltimore, Md. : 1950)203(5)1383-1391(2019 Sep)
Takada YK,Yu J,Shimoda M,Takada Y

The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke.
BMC neurology19(1)44(2019 Mar)
Yi X,Lin J,Zhou Q,Huang R,Chai Z

Nuclear lncRNA HOXD-AS1 suppresses colorectal carcinoma growth and metastasis via inhibiting HOXD3-induced integrin β3 transcriptional activating and MAPK/AKT signalling.
Molecular cancer18(1)31(2019 03)
Yang MH,Zhao L,Wang L,Ou-Yang W,Hu SS,Li WL,Ai ML,Wang YQ,Han Y,Li TT,Ding YQ,Wang S

A Single-Nucleotide Polymorphism of α
Viruses11(2)(2019 02)
Martínez-Valdebenito C,Angulo J,Le Corre N,Marco C,Vial C,Miquel JF,Cerda J,Mertz G,Vial P,Lopez-Lastra M,Ferrés M

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ITGB3 cDNA ORF clone, Homo sapiens(human)

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