HBEGF cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HBEGF
Entrez Gene ID	1839
Full Name	heparin binding EGF like growth factor
Synonyms	DTR,DTS,DTSF,HEGFL
General protein information	Preferred Names heparin binding EGF like growth factor Names proheparin-binding EGF-like growth factor diphtheria toxin receptor (heparin-binding EGF-like growth factor) diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) heparin-binding epidermal growth factor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.3
Disorder MIM:	126150
Disorder Html:	{Diphtheria, susceptibility to} (1)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001945.2	NP_001936.1	proheparin-binding EGF-like growth factor precursor
NM_001945.3	NP_001936.1	proheparin-binding EGF-like growth factor precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HBEGF	XP_001137119.1
Macaca mulatta (Rhesus monkey)	HBEGF	XP_001085848.1
Canis lupus familiaris (dog)	HBEGF	XP_005617336.1
Homo sapiens (human)	HBEGF	NP_001936.1
Bos taurus (cattle)	HBEGF	NP_001137562.1
Rattus norvegicus (Norway rat)	Hbegf	NP_037077.1
Gallus gallus (chicken)	HBEGF	NP_990180.1
Mus musculus (house mouse)	Hbegf	NP_034545.1

Gene Ontology
Bibliography

Related articles in PubMed

Heparin-binding epidermal growth factor (HB-EGF) drives EMT in patients with COPD: implications for disease pathogenesis and novel therapies.
Eapen MS, Sharma P, Thompson IE, Lu W, Myers S, Hansbro PM, Sohal SS
Laboratory investigation; a journal of technical methods and pathology99(2)150-157(2019 02)

Rare mutations of
Xie Y, Ma A, Wang B, Peng R, Jing Y, Wang D, Finnell RH, Qiao B, Wang Y, Wang H, Zheng Y
Clinical science (London, England : 1979)133(2)225-238(2019 01)

BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion.
Sethuraman A, Brown M, Krutilina R, Wu ZH, Seagroves TN, Pfeffer LM, Fan M
Breast cancer research : BCR20(1)117(2018 10)

Heparin-binding epidermal growth factor contributes to COPD disease severity by modulating airway fibrosis and pulmonary epithelial-mesenchymal transition.
Lai T, Li Y, Chen M, Pan G, Wen X, Mai Z, Yuan Y, Lv Y, Lv Q, Cen R, Yi H, Wen M, Li D, Wu B, Wu D, Cao C
Laboratory investigation; a journal of technical methods and pathology98(9)1159-1169(2018 09)

Association of Serum HB-EGF Value and Response to Chemotherapy in Patients with Recurrent Ovarian Cancer.
Izuchi D, Fukagawa S, Yotsumoto F, Shigekawa K, Yoshikawa K, Hirakawa T, Kiyoshima C, Ouk NS, Urushiyama D, Katsuda T, Miyata K, Ito T, Kurakazu M, Araki R, Sanui A, Miyahara D, Murata M, Ito H, Shirota K, Kuroki M, Yasunaga S, Miyamoto S
Anticancer research38(7)4347-4351(2018 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following HBEGF gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HBEGF cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26607	NM_001945.3 Latest version!	Homo sapiens heparin binding EGF like growth factor (HBEGF), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu26607	NM_001945.2	Homo sapiens heparin binding EGF like growth factor (HBEGF), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HBEGF ( NM_001945.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001936.1 Homo sapiens heparin binding EGF like growth factor (HBEGF), mRNA.

Price & Availability↑

CloneID	OHu26607
Clone ID Related Accession (Same CDS sequence)	NM_001945.2 , NM_001945.3
Accession Version	NM_001945.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514390400000
Organism	Homo sapiens(human)
Product	proheparin-binding EGF-like growth factor precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK313202.1, BC033097.1 and D55114.1. On Jul 10, 2008 this sequence version replaced NM_001945.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC033097.1, SRR1803614.27576.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGAAGCTGC TGCCGTCGGT GGTGCTGAAG CTCTTTCTGG CTGCAGTTCT CTCGGCACTG 
GTGACTGGCG AGAGCCTGGA GCGGCTTCGG AGAGGGCTAG CTGCTGGAAC CAGCAACCCG 
GACCCTCCCA CTGTATCCAC GGACCAGCTG CTACCCCTAG GAGGCGGCCG GGACCGGAAA 
GTCCGTGACT TGCAAGAGGC AGATCTGGAC CTTTTGAGAG TCACTTTATC CTCCAAGCCA 
CAAGCACTGG CCACACCAAA CAAGGAGGAG CACGGGAAAA GAAAGAAGAA AGGCAAGGGG 
CTAGGGAAGA AGAGGGACCC ATGTCTTCGG AAATACAAGG ACTTCTGCAT CCATGGAGAA 
TGCAAATATG TGAAGGAGCT CCGGGCTCCC TCCTGCATCT GCCACCCGGG TTACCATGGA 
GAGAGGTGTC ATGGGCTGAG CCTCCCAGTG GAAAATCGCT TATATACCTA TGACCACACA 
ACCATCCTGG CCGTGGTGGC TGTGGTGCTG TCATCTGTCT GTCTGCTGGT CATCGTGGGG 
CTTCTCATGT TTAGGTACCA TAGGAGAGGA GGTTATGATG TGGAAAATGA AGAGAAAGTG 
AAGTTGGGCA TGACTAATTC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001936.1
CDS	276..902
Translation	MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAGTSNPDPPTVSTDQLLPLGGGRDRKVRDLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDVENEEKVKLGMTNSH

Target ORF information:

RefSeq Version	NM_001945.2
Organism	Homo sapiens(human)
Definition	Homo sapiens heparin binding EGF like growth factor (HBEGF), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001945.2

ORF Insert Sequence:

ATGAAGCTGC TGCCGTCGGT GGTGCTGAAG CTCTTTCTGG CTGCAGTTCT CTCGGCACTG 
GTGACTGGCG AGAGCCTGGA GCGGCTTCGG AGAGGGCTAG CTGCTGGAAC CAGCAACCCG 
GACCCTCCCA CTGTATCCAC GGACCAGCTG CTACCCCTAG GAGGCGGCCG GGACCGGAAA 
GTCCGTGACT TGCAAGAGGC AGATCTGGAC CTTTTGAGAG TCACTTTATC CTCCAAGCCA 
CAAGCACTGG CCACACCAAA CAAGGAGGAG CACGGGAAAA GAAAGAAGAA AGGCAAGGGG 
CTAGGGAAGA AGAGGGACCC ATGTCTTCGG AAATACAAGG ACTTCTGCAT CCATGGAGAA 
TGCAAATATG TGAAGGAGCT CCGGGCTCCC TCCTGCATCT GCCACCCGGG TTACCATGGA 
GAGAGGTGTC ATGGGCTGAG CCTCCCAGTG GAAAATCGCT TATATACCTA TGACCACACA 
ACCATCCTGG CCGTGGTGGC TGTGGTGCTG TCATCTGTCT GTCTGCTGGT CATCGTGGGG 
CTTCTCATGT TTAGGTACCA TAGGAGAGGA GGTTATGATG TGGAAAATGA AGAGAAAGTG 
AAGTTGGGCA TGACTAATTC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HBEGF ( NM_001945.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001936.1 Homo sapiens heparin binding EGF like growth factor (HBEGF), mRNA.

Price & Availability↑

CloneID	OHu26607
Clone ID Related Accession (Same CDS sequence)	NM_001945.2 , NM_001945.3
Accession Version	NM_001945.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1574611200000
Organism	Homo sapiens(human)
Product	proheparin-binding EGF-like growth factor precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK313202.1, BC033097.1 and D55114.1. On Nov 22, 2018 this sequence version replaced NM_001945.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.182520.1, SRR3476690.818923.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000230990.7/ ENSP00000230990.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCTGC TGCCGTCGGT GGTGCTGAAG CTCTTTCTGG CTGCAGTTCT CTCGGCACTG 
GTGACTGGCG AGAGCCTGGA GCGGCTTCGG AGAGGGCTAG CTGCTGGAAC CAGCAACCCG 
GACCCTCCCA CTGTATCCAC GGACCAGCTG CTACCCCTAG GAGGCGGCCG GGACCGGAAA 
GTCCGTGACT TGCAAGAGGC AGATCTGGAC CTTTTGAGAG TCACTTTATC CTCCAAGCCA 
CAAGCACTGG CCACACCAAA CAAGGAGGAG CACGGGAAAA GAAAGAAGAA AGGCAAGGGG 
CTAGGGAAGA AGAGGGACCC ATGTCTTCGG AAATACAAGG ACTTCTGCAT CCATGGAGAA 
TGCAAATATG TGAAGGAGCT CCGGGCTCCC TCCTGCATCT GCCACCCGGG TTACCATGGA 
GAGAGGTGTC ATGGGCTGAG CCTCCCAGTG GAAAATCGCT TATATACCTA TGACCACACA 
ACCATCCTGG CCGTGGTGGC TGTGGTGCTG TCATCTGTCT GTCTGCTGGT CATCGTGGGG 
CTTCTCATGT TTAGGTACCA TAGGAGAGGA GGTTATGATG TGGAAAATGA AGAGAAAGTG 
AAGTTGGGCA TGACTAATTC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001936.1
CDS	276..902
Translation	MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAGTSNPDPPTVSTDQLLPLGGGRDRKVRDLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDVENEEKVKLGMTNSH

Target ORF information:

RefSeq Version	NM_001945.3
Organism	Homo sapiens(human)
Definition	Homo sapiens heparin binding EGF like growth factor (HBEGF), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001945.3

ORF Insert Sequence:

ATGAAGCTGC TGCCGTCGGT GGTGCTGAAG CTCTTTCTGG CTGCAGTTCT CTCGGCACTG 
GTGACTGGCG AGAGCCTGGA GCGGCTTCGG AGAGGGCTAG CTGCTGGAAC CAGCAACCCG 
GACCCTCCCA CTGTATCCAC GGACCAGCTG CTACCCCTAG GAGGCGGCCG GGACCGGAAA 
GTCCGTGACT TGCAAGAGGC AGATCTGGAC CTTTTGAGAG TCACTTTATC CTCCAAGCCA 
CAAGCACTGG CCACACCAAA CAAGGAGGAG CACGGGAAAA GAAAGAAGAA AGGCAAGGGG 
CTAGGGAAGA AGAGGGACCC ATGTCTTCGG AAATACAAGG ACTTCTGCAT CCATGGAGAA 
TGCAAATATG TGAAGGAGCT CCGGGCTCCC TCCTGCATCT GCCACCCGGG TTACCATGGA 
GAGAGGTGTC ATGGGCTGAG CCTCCCAGTG GAAAATCGCT TATATACCTA TGACCACACA 
ACCATCCTGG CCGTGGTGGC TGTGGTGCTG TCATCTGTCT GTCTGCTGGT CATCGTGGGG 
CTTCTCATGT TTAGGTACCA TAGGAGAGGA GGTTATGATG TGGAAAATGA AGAGAAAGTG 
AAGTTGGGCA TGACTAATTC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Heparin-binding epidermal growth factor (HB-EGF) drives EMT in patients with COPD: implications for disease pathogenesis and novel therapies.
Laboratory investigation; a journal of technical methods and pathology99(2)150-157(2019 02)
Eapen MS,Sharma P,Thompson IE,Lu W,Myers S,Hansbro PM,Sohal SS

Rare mutations of
Clinical science (London, England : 1979)133(2)225-238(2019 01)
Xie Y,Ma A,Wang B,Peng R,Jing Y,Wang D,Finnell RH,Qiao B,Wang Y,Wang H,Zheng Y

BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion.
Breast cancer research : BCR20(1)117(2018 10)
Sethuraman A,Brown M,Krutilina R,Wu ZH,Seagroves TN,Pfeffer LM,Fan M

Heparin-binding epidermal growth factor contributes to COPD disease severity by modulating airway fibrosis and pulmonary epithelial-mesenchymal transition.
Laboratory investigation; a journal of technical methods and pathology98(9)1159-1169(2018 09)
Lai T,Li Y,Chen M,Pan G,Wen X,Mai Z,Yuan Y,Lv Y,Lv Q,Cen R,Yi H,Wen M,Li D,Wu B,Wu D,Cao C

Association of Serum HB-EGF Value and Response to Chemotherapy in Patients with Recurrent Ovarian Cancer.
Anticancer research38(7)4347-4351(2018 Jul)
Izuchi D,Fukagawa S,Yotsumoto F,Shigekawa K,Yoshikawa K,Hirakawa T,Kiyoshima C,Ouk NS,Urushiyama D,Katsuda T,Miyata K,Ito T,Kurakazu M,Araki R,Sanui A,Miyahara D,Murata M,Ito H,Shirota K,Kuroki M,Yasunaga S,Miyamoto S

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HBEGF cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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