| Gene Symbol | IL3 |
| Entrez Gene ID | 3562 |
| Full Name | interleukin 3 |
| Synonyms | IL-3,MCGF,MULTI-CSF |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
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IL3 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following IL3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu16440 Clone ID Related Accession (Same CDS sequence) NM_000588.4 , NM_000588.3 Accession Version NM_000588.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 459bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1575043200000 Organism Homo sapiens(human) Product interleukin-3 precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC034228.6. On May 17, 2019 this sequence version replaced NM_000588.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M17115.1, M20137.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155628 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000296870.3/ ENSP00000296870.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
1
61
121
181
241
301
361
421ATGAGCCGCC TGCCCGTCCT GCTCCTGCTC CAACTCCTGG TCCGCCCCGG ACTCCAAGCT
CCCATGACCC AGACAACGCC CTTGAAGACA AGCTGGGTTA ACTGCTCTAA CATGATCGAT
GAAATTATAA CACACTTAAA GCAGCCACCT TTGCCTTTGC TGGACTTCAA CAACCTCAAT
GGGGAAGACC AAGACATTCT GATGGAAAAT AACCTTCGAA GGCCAAACCT GGAGGCATTC
AACAGGGCTG TCAAGAGTTT ACAGAACGCA TCAGCAATTG AGAGCATTCT TAAAAATCTC
CTGCCATGTC TGCCCCTGGC CACGGCCGCA CCCACGCGAC ATCCAATCCA TATCAAGGAC
GGTGACTGGA ATGAATTCCG GAGGAAACTG ACGTTCTATC TGAAAACCCT TGAGAATGCG
CAGGCTCAAC AGACGACTTT GAGCCTCGCG ATCTTTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_000579.2 CDS 53..511 Translation 
Target ORF information:
RefSeq Version NM_000588.4 Organism Homo sapiens(human) Definition Homo sapiens interleukin 3 (IL3), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_000588.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421ATGAGCCGCC TGCCCGTCCT GCTCCTGCTC CAACTCCTGG TCCGCCCCGG ACTCCAAGCT
CCCATGACCC AGACAACGCC CTTGAAGACA AGCTGGGTTA ACTGCTCTAA CATGATCGAT
GAAATTATAA CACACTTAAA GCAGCCACCT TTGCCTTTGC TGGACTTCAA CAACCTCAAT
GGGGAAGACC AAGACATTCT GATGGAAAAT AACCTTCGAA GGCCAAACCT GGAGGCATTC
AACAGGGCTG TCAAGAGTTT ACAGAACGCA TCAGCAATTG AGAGCATTCT TAAAAATCTC
CTGCCATGTC TGCCCCTGGC CACGGCCGCA CCCACGCGAC ATCCAATCCA TATCAAGGAC
GGTGACTGGA ATGAATTCCG GAGGAAACTG ACGTTCTATC TGAAAACCCT TGAGAATGCG
CAGGCTCAAC AGACGACTTT GAGCCTCGCG ATCTTTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu16440 Clone ID Related Accession (Same CDS sequence) NM_000588.4 , NM_000588.3 Accession Version NM_000588.3 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 459bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1550160000000 Organism Homo sapiens(human) Product interleukin-3 precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M20137.1. On Feb 19, 2003 this sequence version replaced NM_000588.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M20137.1, M17115.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155628 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421ATGAGCCGCC TGCCCGTCCT GCTCCTGCTC CAACTCCTGG TCCGCCCCGG ACTCCAAGCT
CCCATGACCC AGACAACGCC CTTGAAGACA AGCTGGGTTA ACTGCTCTAA CATGATCGAT
GAAATTATAA CACACTTAAA GCAGCCACCT TTGCCTTTGC TGGACTTCAA CAACCTCAAT
GGGGAAGACC AAGACATTCT GATGGAAAAT AACCTTCGAA GGCCAAACCT GGAGGCATTC
AACAGGGCTG TCAAGAGTTT ACAGAACGCA TCAGCAATTG AGAGCATTCT TAAAAATCTC
CTGCCATGTC TGCCCCTGGC CACGGCCGCA CCCACGCGAC ATCCAATCCA TATCAAGGAC
GGTGACTGGA ATGAATTCCG GAGGAAACTG ACGTTCTATC TGAAAACCCT TGAGAATGCG
CAGGCTCAAC AGACGACTTT GAGCCTCGCG ATCTTTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_000579.2 CDS 54..512 Translation
Target ORF information:
RefSeq Version NM_000588.3 Organism Homo sapiens(human) Definition Homo sapiens interleukin 3 (IL3), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_000588.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421ATGAGCCGCC TGCCCGTCCT GCTCCTGCTC CAACTCCTGG TCCGCCCCGG ACTCCAAGCT
CCCATGACCC AGACAACGCC CTTGAAGACA AGCTGGGTTA ACTGCTCTAA CATGATCGAT
GAAATTATAA CACACTTAAA GCAGCCACCT TTGCCTTTGC TGGACTTCAA CAACCTCAAT
GGGGAAGACC AAGACATTCT GATGGAAAAT AACCTTCGAA GGCCAAACCT GGAGGCATTC
AACAGGGCTG TCAAGAGTTT ACAGAACGCA TCAGCAATTG AGAGCATTCT TAAAAATCTC
CTGCCATGTC TGCCCCTGGC CACGGCCGCA CCCACGCGAC ATCCAATCCA TATCAAGGAC
GGTGACTGGA ATGAATTCCG GAGGAAACTG ACGTTCTATC TGAAAACCCT TGAGAATGCG
CAGGCTCAAC AGACGACTTT GAGCCTCGCG ATCTTTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Interleukin-3 Polymorphism is Associated with Miscarriage of Fresh in Vitro Fertilization Cycles.
International journal of environmental research and public health16(6)(2019 03)
Wu CH,Lee TH,Yang SF,Tsao HM,Chang YJ,Chou CH,Lee MS
Malignant Transformation of Fanconi Anemia Complementation Group D2-deficient (
In vivo (Athens, Greece)33(2)303-311(2019 Mar-Apr)
Zhang X,Fisher R,Shields D,Hou W,Franicola D,Wang H,Epperly MW,Rigatti L,Greenberger JS
Innate Immune Modulation by GM-CSF and IL-3 in Health and Disease.
International journal of molecular sciences20(4)(2019 Feb)
Borriello F,Galdiero MR,Varricchi G,Loffredo S,Spadaro G,Marone G
Expression of IL-3 receptors and impact of IL-3 on human T and B cells.
Cellular immunology33449-60(2018 12)
Renner K,Metz S,Metzger AM,Neumayer S,Schmidbauer K,Talke Y,Buchtler S,Halbritter D,Mack M
Role of interleukin-3 as a prognostic marker in septic patients.
Revista Brasileira de terapia intensiva30(4)443-452(2018 Oct-Dec)
Borges IN,Resende CB,Vieira ÉLM,Silva JLPD,Andrade MVM,Souza AJ,Badaró E,Carneiro RM,Teixeira AL Jr,Nobre V
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