MAP3K11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAP3K11
Entrez Gene ID	4296
Full Name	mitogen-activated protein kinase kinase kinase 11
Synonyms	MEKK11,MLK-3,MLK3,PTK1,SPRK
General protein information	Preferred Names mitogen-activated protein kinase kinase kinase 11 Names mitogen-activated protein kinase kinase kinase 11 SH3 domain-containing proline-rich kinase mixed lineage kinase 3 protein-tyrosine kinase PTK1 src-homology 3 domain-containing proline-rich kinase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.1
Summary	The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008].
Disorder MIM:	600050

mRNA and Protein(s)

mRNA	Protein	Name
NM_002419.3	NP_002410.1	mitogen-activated protein kinase kinase kinase 11
NM_002419.4	NP_002410.1	mitogen-activated protein kinase kinase kinase 11

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MAP3K11	NP_001095461.1
Mus musculus (house mouse)	Map3k11	NP_071295.2
Arabidopsis thaliana (thale cress)	HT1	NP_176430.1
Homo sapiens (human)	MAP3K11	NP_002410.1
Canis lupus familiaris (dog)	MAP3K11	XP_540853.3
Pan troglodytes (chimpanzee)	MAP3K11	XP_508556.2
Macaca mulatta (Rhesus monkey)	MAP3K11	XP_001113486.1
Oryza sativa (rice)	Os06g0636600	NP_001058144.1
Rattus norvegicus (Norway rat)	Map3k11	NP_001013168.1

Gene Ontology
Bibliography

Related articles in PubMed

Mixed lineage kinase 3 promotes breast tumorigenesis via phosphorylation and activation of p21-activated kinase 1.
Das S, Nair RS, Mishra R, Sondarva G, Viswakarma N, Abdelkarim H, Gaponenko V, Rana B, Rana A
Oncogene38(19)3569-3584(2019 05)

IFN-γ-inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5.
Saleiro D, Blyth GT, Kosciuczuk EM, Ozark PA, Majchrzak-Kita B, Arslan AD, Fischietti M, Reddy NK, Horvath CM, Davis RJ, Fish EN, Platanias LC
Science signaling11(557)(2018 11)

Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3.
Kokoszka ME, Kall SL, Khosla S, McGinnis JE, Lavie A, Kay BK
The Journal of biological chemistry293(35)13553-13565(2018 08)

A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy.
Silva CT, Zorkoltseva IV, Niemeijer MN, van den Berg ME, Amin N, Demirkan A, van Leeuwen E, Iglesias AI, Piñeros-Hernández LB, Restrepo CM, Kors JA, Kirichenko AV, Willemsen R, Oostra BA, Stricker BH, Uitterlinden AG, Axenovich TI, van Duijn CM, Isaacs A
BMC medical genomics11(1)22(2018 03)

MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells.
Schroyer AL, Stimes NW, Abi Saab WF, Chadee DN
Oncogene37(8)1031-1040(2018 02)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MAP3K11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAP3K11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10924	NM_002419.4 Latest version!	Homo sapiens mitogen-activated protein kinase kinase kinase 11 (MAP3K11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
View Old Accession Versions >>
OHu10924	NM_002419.3	Homo sapiens mitogen-activated protein kinase kinase kinase 11 (MAP3K11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAP3K11 ( NM_002419.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002410.1 Homo sapiens mitogen-activated protein kinase kinase kinase 11 (MAP3K11), mRNA.

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CloneID	OHu10924
Clone ID Related Accession (Same CDS sequence)	NM_002419.3 , NM_002419.4
Accession Version	NM_002419.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2544bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514390400000
Organism	Homo sapiens(human)
Product	mitogen-activated protein kinase kinase kinase 11
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU119082.2, L32976.1 and U07747.1. On Dec 3, 2004 this sequence version replaced NM_002419.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U07747.1, AK222781.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCCT TGAAGAGCCT CTTCCTCAAG AGCCCTCTAG GGTCATGGAA TGGCAGTGGC 
AGCGGGGGTG GTGGGGGCGG TGGAGGAGGC CGGCCTGAGG GGTCTCCAAA GGCAGCGGGT 
TATGCCAACC CGGTGTGGAC AGCCCTGTTC GACTACGAGC CCAGTGGGCA GGATGAGCTG 
GCCCTGAGGA AGGGTGACCG TGTGGAGGTG CTGTCCCGGG ACGCAGCCAT CTCAGGAGAC 
GAGGGCTGGT GGGCGGGCCA GGTGGGTGGC CAGGTGGGCA TCTTCCCGTC CAACTATGTG 
TCTCGGGGTG GCGGCCCGCC CCCCTGCGAG GTGGCCAGCT TCCAGGAGCT GCGGCTGGAG 
GAGGTGATCG GCATTGGAGG CTTTGGCAAG GTGTACAGGG GCAGCTGGCG AGGTGAGCTG 
GTGGCTGTGA AGGCAGCTCG CCAGGACCCC GATGAGGACA TCAGTGTGAC AGCCGAGAGC 
GTTCGCCAGG AGGCCCGGCT CTTCGCCATG CTGGCACACC CCAACATCAT TGCCCTCAAG 
GCTGTGTGCC TGGAGGAGCC CAACCTGTGC CTGGTGATGG AGTATGCAGC CGGTGGGCCC 
CTCAGCCGAG CTCTGGCCGG GCGGCGCGTG CCTCCCCATG TGCTGGTCAA CTGGGCTGTG 
CAGATTGCCC GTGGGATGCA CTACCTGCAC TGCGAGGCCC TGGTGCCCGT CATCCACCGT 
GATCTCAAGT CCAACAACAT TTTGCTGCTG CAGCCCATTG AGAGTGACGA CATGGAGCAC 
AAGACCCTGA AGATCACCGA CTTTGGCCTG GCCCGAGAGT GGCACAAAAC CACACAAATG 
AGTGCCGCGG GCACCTACGC CTGGATGGCT CCTGAGGTTA TCAAGGCCTC CACCTTCTCT 
AAGGGCAGTG ACGTCTGGAG TTTTGGGGTG CTGCTGTGGG AACTGCTGAC CGGGGAGGTG 
CCATACCGTG GCATTGACTG CCTTGCTGTG GCCTATGGCG TAGCTGTTAA CAAGCTCACA 
CTGCCCATCC CATCCACCTG CCCCGAGCCC TTCGCACAGC TTATGGCCGA CTGCTGGGCG 
CAGGACCCCC ACCGCAGGCC CGACTTCGCC TCCATCCTGC AGCAGTTGGA GGCGCTGGAG 
GCACAGGTCC TACGGGAAAT GCCGCGGGAC TCCTTCCATT CCATGCAGGA AGGCTGGAAG 
CGCGAGATCC AGGGTCTCTT CGACGAGCTG CGAGCCAAGG AAAAGGAACT ACTGAGCCGC 
GAGGAGGAGC TGACGCGAGC GGCGCGCGAG CAGCGGTCAC AGGCGGAGCA GCTGCGGCGG 
CGCGAGCACC TGCTGGCCCA GTGGGAGCTA GAGGTGTTCG AGCGCGAGCT GACGCTGCTG 
CTGCAGCAGG TGGACCGCGA GCGACCGCAC GTGCGCCGCC GCCGCGGGAC ATTCAAGCGC 
AGCAAGCTCC GGGCGCGCGA CGGCGGCGAG CGTATCAGCA TGCCACTCGA CTTCAAGCAC 
CGCATCACCG TGCAGGCCTC ACCCGGCCTT GACCGGAGGA GAAACGTCTT CGAGGTCGGG 
CCTGGGGATT CGCCCACCTT TCCCCGGTTC CGAGCCATCC AGTTGGAGCC TGCAGAGCCA 
GGCCAGGCAT GGGGCCGCCA GTCCCCCCGA CGTCTGGAGG ACTCAAGCAA TGGAGAGCGG 
CGAGCATGCT GGGCTTGGGG TCCCAGTTCC CCCAAGCCTG GGGAAGCCCA GAATGGGAGG 
AGAAGGTCCC GCATGGACGA AGCCACATGG TACCTGGATT CAGATGACTC ATCCCCCTTA 
GGATCTCCTT CCACACCCCC AGCACTCAAT GGTAACCCCC CGCGGCCTAG CCTGGAGCCC 
GAGGAGCCCA AGAGGCCTGT CCCCGCAGAG CGCGGTAGCA GCTCTGGGAC GCCCAAGCTG 
ATCCAGCGGG CGCTGCTGCG CGGCACCGCC CTGCTCGCCT CGCTGGGCCT TGGCCGCGAC 
CTGCAGCCGC CGGGAGGCCC AGGACGCGAG CGCGGGGAGT CCCCGACAAC ACCCCCCACG 
CCAACGCCCG CGCCCTGCCC GACCGAGCCG CCCCCTTCCC CGCTCATCTG CTTCTCGCTC 
AAGACGCCCG ACTCCCCGCC CACTCCTGCA CCCCTGTTGC TGGACCTGGG TATCCCTGTG 
GGCCAGCGGT CAGCCAAGAG CCCCCGACGT GAGGAGGAGC CCCGCGGAGG CACTGTCTCA 
CCCCCACCGG GGACATCACG CTCTGCTCCT GGCACCCCAG GCACCCCACG TTCACCACCC 
CTGGGCCTCA TCAGCCGACC TCGGCCCTCG CCCCTTCGCA GCCGCATTGA TCCCTGGAGC 
TTTGTGTCAG CTGGGCCACG GCCTTCTCCC CTGCCATCAC CACAGCCTGC ACCCCGCCGA 
GCACCCTGGA CCTTGTTCCC GGACTCAGAC CCCTTCTGGG ACTCCCCACC TGCCAACCCC 
TTCCAGGGGG GCCCCCAGGA CTGCAGGGCA CAGACCAAAG ACATGGGTGC CCAGGCCCCG 
TGGGTGCCGG AAGCGGGGCC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002410.1
CDS	494..3037
Translation	MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP

Target ORF information:

RefSeq Version	NM_002419.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase kinase 11 (MAP3K11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002419.3

ORF Insert Sequence:

ATGGAGCCCT TGAAGAGCCT CTTCCTCAAG AGCCCTCTAG GGTCATGGAA TGGCAGTGGC 
AGCGGGGGTG GTGGGGGCGG TGGAGGAGGC CGGCCTGAGG GGTCTCCAAA GGCAGCGGGT 
TATGCCAACC CGGTGTGGAC AGCCCTGTTC GACTACGAGC CCAGTGGGCA GGATGAGCTG 
GCCCTGAGGA AGGGTGACCG TGTGGAGGTG CTGTCCCGGG ACGCAGCCAT CTCAGGAGAC 
GAGGGCTGGT GGGCGGGCCA GGTGGGTGGC CAGGTGGGCA TCTTCCCGTC CAACTATGTG 
TCTCGGGGTG GCGGCCCGCC CCCCTGCGAG GTGGCCAGCT TCCAGGAGCT GCGGCTGGAG 
GAGGTGATCG GCATTGGAGG CTTTGGCAAG GTGTACAGGG GCAGCTGGCG AGGTGAGCTG 
GTGGCTGTGA AGGCAGCTCG CCAGGACCCC GATGAGGACA TCAGTGTGAC AGCCGAGAGC 
GTTCGCCAGG AGGCCCGGCT CTTCGCCATG CTGGCACACC CCAACATCAT TGCCCTCAAG 
GCTGTGTGCC TGGAGGAGCC CAACCTGTGC CTGGTGATGG AGTATGCAGC CGGTGGGCCC 
CTCAGCCGAG CTCTGGCCGG GCGGCGCGTG CCTCCCCATG TGCTGGTCAA CTGGGCTGTG 
CAGATTGCCC GTGGGATGCA CTACCTGCAC TGCGAGGCCC TGGTGCCCGT CATCCACCGT 
GATCTCAAGT CCAACAACAT TTTGCTGCTG CAGCCCATTG AGAGTGACGA CATGGAGCAC 
AAGACCCTGA AGATCACCGA CTTTGGCCTG GCCCGAGAGT GGCACAAAAC CACACAAATG 
AGTGCCGCGG GCACCTACGC CTGGATGGCT CCTGAGGTTA TCAAGGCCTC CACCTTCTCT 
AAGGGCAGTG ACGTCTGGAG TTTTGGGGTG CTGCTGTGGG AACTGCTGAC CGGGGAGGTG 
CCATACCGTG GCATTGACTG CCTTGCTGTG GCCTATGGCG TAGCTGTTAA CAAGCTCACA 
CTGCCCATCC CATCCACCTG CCCCGAGCCC TTCGCACAGC TTATGGCCGA CTGCTGGGCG 
CAGGACCCCC ACCGCAGGCC CGACTTCGCC TCCATCCTGC AGCAGTTGGA GGCGCTGGAG 
GCACAGGTCC TACGGGAAAT GCCGCGGGAC TCCTTCCATT CCATGCAGGA AGGCTGGAAG 
CGCGAGATCC AGGGTCTCTT CGACGAGCTG CGAGCCAAGG AAAAGGAACT ACTGAGCCGC 
GAGGAGGAGC TGACGCGAGC GGCGCGCGAG CAGCGGTCAC AGGCGGAGCA GCTGCGGCGG 
CGCGAGCACC TGCTGGCCCA GTGGGAGCTA GAGGTGTTCG AGCGCGAGCT GACGCTGCTG 
CTGCAGCAGG TGGACCGCGA GCGACCGCAC GTGCGCCGCC GCCGCGGGAC ATTCAAGCGC 
AGCAAGCTCC GGGCGCGCGA CGGCGGCGAG CGTATCAGCA TGCCACTCGA CTTCAAGCAC 
CGCATCACCG TGCAGGCCTC ACCCGGCCTT GACCGGAGGA GAAACGTCTT CGAGGTCGGG 
CCTGGGGATT CGCCCACCTT TCCCCGGTTC CGAGCCATCC AGTTGGAGCC TGCAGAGCCA 
GGCCAGGCAT GGGGCCGCCA GTCCCCCCGA CGTCTGGAGG ACTCAAGCAA TGGAGAGCGG 
CGAGCATGCT GGGCTTGGGG TCCCAGTTCC CCCAAGCCTG GGGAAGCCCA GAATGGGAGG 
AGAAGGTCCC GCATGGACGA AGCCACATGG TACCTGGATT CAGATGACTC ATCCCCCTTA 
GGATCTCCTT CCACACCCCC AGCACTCAAT GGTAACCCCC CGCGGCCTAG CCTGGAGCCC 
GAGGAGCCCA AGAGGCCTGT CCCCGCAGAG CGCGGTAGCA GCTCTGGGAC GCCCAAGCTG 
ATCCAGCGGG CGCTGCTGCG CGGCACCGCC CTGCTCGCCT CGCTGGGCCT TGGCCGCGAC 
CTGCAGCCGC CGGGAGGCCC AGGACGCGAG CGCGGGGAGT CCCCGACAAC ACCCCCCACG 
CCAACGCCCG CGCCCTGCCC GACCGAGCCG CCCCCTTCCC CGCTCATCTG CTTCTCGCTC 
AAGACGCCCG ACTCCCCGCC CACTCCTGCA CCCCTGTTGC TGGACCTGGG TATCCCTGTG 
GGCCAGCGGT CAGCCAAGAG CCCCCGACGT GAGGAGGAGC CCCGCGGAGG CACTGTCTCA 
CCCCCACCGG GGACATCACG CTCTGCTCCT GGCACCCCAG GCACCCCACG TTCACCACCC 
CTGGGCCTCA TCAGCCGACC TCGGCCCTCG CCCCTTCGCA GCCGCATTGA TCCCTGGAGC 
TTTGTGTCAG CTGGGCCACG GCCTTCTCCC CTGCCATCAC CACAGCCTGC ACCCCGCCGA 
GCACCCTGGA CCTTGTTCCC GGACTCAGAC CCCTTCTGGG ACTCCCCACC TGCCAACCCC 
TTCCAGGGGG GCCCCCAGGA CTGCAGGGCA CAGACCAAAG ACATGGGTGC CCAGGCCCCG 
TGGGTGCCGG AAGCGGGGCC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAP3K11 ( NM_002419.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002410.1 Homo sapiens mitogen-activated protein kinase kinase kinase 11 (MAP3K11), mRNA.

Price & Availability↑

CloneID	OHu10924
Clone ID Related Accession (Same CDS sequence)	NM_002419.3 , NM_002419.4
Accession Version	NM_002419.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2544bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	mitogen-activated protein kinase kinase kinase 11
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L32976.1 and U07747.1. On Nov 22, 2018 this sequence version replaced NM_002419.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC011263.2, L32976.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000309100.8/ ENSP00000309597.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCCCT TGAAGAGCCT CTTCCTCAAG AGCCCTCTAG GGTCATGGAA TGGCAGTGGC 
AGCGGGGGTG GTGGGGGCGG TGGAGGAGGC CGGCCTGAGG GGTCTCCAAA GGCAGCGGGT 
TATGCCAACC CGGTGTGGAC AGCCCTGTTC GACTACGAGC CCAGTGGGCA GGATGAGCTG 
GCCCTGAGGA AGGGTGACCG TGTGGAGGTG CTGTCCCGGG ACGCAGCCAT CTCAGGAGAC 
GAGGGCTGGT GGGCGGGCCA GGTGGGTGGC CAGGTGGGCA TCTTCCCGTC CAACTATGTG 
TCTCGGGGTG GCGGCCCGCC CCCCTGCGAG GTGGCCAGCT TCCAGGAGCT GCGGCTGGAG 
GAGGTGATCG GCATTGGAGG CTTTGGCAAG GTGTACAGGG GCAGCTGGCG AGGTGAGCTG 
GTGGCTGTGA AGGCAGCTCG CCAGGACCCC GATGAGGACA TCAGTGTGAC AGCCGAGAGC 
GTTCGCCAGG AGGCCCGGCT CTTCGCCATG CTGGCACACC CCAACATCAT TGCCCTCAAG 
GCTGTGTGCC TGGAGGAGCC CAACCTGTGC CTGGTGATGG AGTATGCAGC CGGTGGGCCC 
CTCAGCCGAG CTCTGGCCGG GCGGCGCGTG CCTCCCCATG TGCTGGTCAA CTGGGCTGTG 
CAGATTGCCC GTGGGATGCA CTACCTGCAC TGCGAGGCCC TGGTGCCCGT CATCCACCGT 
GATCTCAAGT CCAACAACAT TTTGCTGCTG CAGCCCATTG AGAGTGACGA CATGGAGCAC 
AAGACCCTGA AGATCACCGA CTTTGGCCTG GCCCGAGAGT GGCACAAAAC CACACAAATG 
AGTGCCGCGG GCACCTACGC CTGGATGGCT CCTGAGGTTA TCAAGGCCTC CACCTTCTCT 
AAGGGCAGTG ACGTCTGGAG TTTTGGGGTG CTGCTGTGGG AACTGCTGAC CGGGGAGGTG 
CCATACCGTG GCATTGACTG CCTTGCTGTG GCCTATGGCG TAGCTGTTAA CAAGCTCACA 
CTGCCCATCC CATCCACCTG CCCCGAGCCC TTCGCACAGC TTATGGCCGA CTGCTGGGCG 
CAGGACCCCC ACCGCAGGCC CGACTTCGCC TCCATCCTGC AGCAGTTGGA GGCGCTGGAG 
GCACAGGTCC TACGGGAAAT GCCGCGGGAC TCCTTCCATT CCATGCAGGA AGGCTGGAAG 
CGCGAGATCC AGGGTCTCTT CGACGAGCTG CGAGCCAAGG AAAAGGAACT ACTGAGCCGC 
GAGGAGGAGC TGACGCGAGC GGCGCGCGAG CAGCGGTCAC AGGCGGAGCA GCTGCGGCGG 
CGCGAGCACC TGCTGGCCCA GTGGGAGCTA GAGGTGTTCG AGCGCGAGCT GACGCTGCTG 
CTGCAGCAGG TGGACCGCGA GCGACCGCAC GTGCGCCGCC GCCGCGGGAC ATTCAAGCGC 
AGCAAGCTCC GGGCGCGCGA CGGCGGCGAG CGTATCAGCA TGCCACTCGA CTTCAAGCAC 
CGCATCACCG TGCAGGCCTC ACCCGGCCTT GACCGGAGGA GAAACGTCTT CGAGGTCGGG 
CCTGGGGATT CGCCCACCTT TCCCCGGTTC CGAGCCATCC AGTTGGAGCC TGCAGAGCCA 
GGCCAGGCAT GGGGCCGCCA GTCCCCCCGA CGTCTGGAGG ACTCAAGCAA TGGAGAGCGG 
CGAGCATGCT GGGCTTGGGG TCCCAGTTCC CCCAAGCCTG GGGAAGCCCA GAATGGGAGG 
AGAAGGTCCC GCATGGACGA AGCCACATGG TACCTGGATT CAGATGACTC ATCCCCCTTA 
GGATCTCCTT CCACACCCCC AGCACTCAAT GGTAACCCCC CGCGGCCTAG CCTGGAGCCC 
GAGGAGCCCA AGAGGCCTGT CCCCGCAGAG CGCGGTAGCA GCTCTGGGAC GCCCAAGCTG 
ATCCAGCGGG CGCTGCTGCG CGGCACCGCC CTGCTCGCCT CGCTGGGCCT TGGCCGCGAC 
CTGCAGCCGC CGGGAGGCCC AGGACGCGAG CGCGGGGAGT CCCCGACAAC ACCCCCCACG 
CCAACGCCCG CGCCCTGCCC GACCGAGCCG CCCCCTTCCC CGCTCATCTG CTTCTCGCTC 
AAGACGCCCG ACTCCCCGCC CACTCCTGCA CCCCTGTTGC TGGACCTGGG TATCCCTGTG 
GGCCAGCGGT CAGCCAAGAG CCCCCGACGT GAGGAGGAGC CCCGCGGAGG CACTGTCTCA 
CCCCCACCGG GGACATCACG CTCTGCTCCT GGCACCCCAG GCACCCCACG TTCACCACCC 
CTGGGCCTCA TCAGCCGACC TCGGCCCTCG CCCCTTCGCA GCCGCATTGA TCCCTGGAGC 
TTTGTGTCAG CTGGGCCACG GCCTTCTCCC CTGCCATCAC CACAGCCTGC ACCCCGCCGA 
GCACCCTGGA CCTTGTTCCC GGACTCAGAC CCCTTCTGGG ACTCCCCACC TGCCAACCCC 
TTCCAGGGGG GCCCCCAGGA CTGCAGGGCA CAGACCAAAG ACATGGGTGC CCAGGCCCCG 
TGGGTGCCGG AAGCGGGGCC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002410.1
CDS	466..3009
Translation	MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP

Target ORF information:

RefSeq Version	NM_002419.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase kinase 11 (MAP3K11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002419.4

ORF Insert Sequence:

ATGGAGCCCT TGAAGAGCCT CTTCCTCAAG AGCCCTCTAG GGTCATGGAA TGGCAGTGGC 
AGCGGGGGTG GTGGGGGCGG TGGAGGAGGC CGGCCTGAGG GGTCTCCAAA GGCAGCGGGT 
TATGCCAACC CGGTGTGGAC AGCCCTGTTC GACTACGAGC CCAGTGGGCA GGATGAGCTG 
GCCCTGAGGA AGGGTGACCG TGTGGAGGTG CTGTCCCGGG ACGCAGCCAT CTCAGGAGAC 
GAGGGCTGGT GGGCGGGCCA GGTGGGTGGC CAGGTGGGCA TCTTCCCGTC CAACTATGTG 
TCTCGGGGTG GCGGCCCGCC CCCCTGCGAG GTGGCCAGCT TCCAGGAGCT GCGGCTGGAG 
GAGGTGATCG GCATTGGAGG CTTTGGCAAG GTGTACAGGG GCAGCTGGCG AGGTGAGCTG 
GTGGCTGTGA AGGCAGCTCG CCAGGACCCC GATGAGGACA TCAGTGTGAC AGCCGAGAGC 
GTTCGCCAGG AGGCCCGGCT CTTCGCCATG CTGGCACACC CCAACATCAT TGCCCTCAAG 
GCTGTGTGCC TGGAGGAGCC CAACCTGTGC CTGGTGATGG AGTATGCAGC CGGTGGGCCC 
CTCAGCCGAG CTCTGGCCGG GCGGCGCGTG CCTCCCCATG TGCTGGTCAA CTGGGCTGTG 
CAGATTGCCC GTGGGATGCA CTACCTGCAC TGCGAGGCCC TGGTGCCCGT CATCCACCGT 
GATCTCAAGT CCAACAACAT TTTGCTGCTG CAGCCCATTG AGAGTGACGA CATGGAGCAC 
AAGACCCTGA AGATCACCGA CTTTGGCCTG GCCCGAGAGT GGCACAAAAC CACACAAATG 
AGTGCCGCGG GCACCTACGC CTGGATGGCT CCTGAGGTTA TCAAGGCCTC CACCTTCTCT 
AAGGGCAGTG ACGTCTGGAG TTTTGGGGTG CTGCTGTGGG AACTGCTGAC CGGGGAGGTG 
CCATACCGTG GCATTGACTG CCTTGCTGTG GCCTATGGCG TAGCTGTTAA CAAGCTCACA 
CTGCCCATCC CATCCACCTG CCCCGAGCCC TTCGCACAGC TTATGGCCGA CTGCTGGGCG 
CAGGACCCCC ACCGCAGGCC CGACTTCGCC TCCATCCTGC AGCAGTTGGA GGCGCTGGAG 
GCACAGGTCC TACGGGAAAT GCCGCGGGAC TCCTTCCATT CCATGCAGGA AGGCTGGAAG 
CGCGAGATCC AGGGTCTCTT CGACGAGCTG CGAGCCAAGG AAAAGGAACT ACTGAGCCGC 
GAGGAGGAGC TGACGCGAGC GGCGCGCGAG CAGCGGTCAC AGGCGGAGCA GCTGCGGCGG 
CGCGAGCACC TGCTGGCCCA GTGGGAGCTA GAGGTGTTCG AGCGCGAGCT GACGCTGCTG 
CTGCAGCAGG TGGACCGCGA GCGACCGCAC GTGCGCCGCC GCCGCGGGAC ATTCAAGCGC 
AGCAAGCTCC GGGCGCGCGA CGGCGGCGAG CGTATCAGCA TGCCACTCGA CTTCAAGCAC 
CGCATCACCG TGCAGGCCTC ACCCGGCCTT GACCGGAGGA GAAACGTCTT CGAGGTCGGG 
CCTGGGGATT CGCCCACCTT TCCCCGGTTC CGAGCCATCC AGTTGGAGCC TGCAGAGCCA 
GGCCAGGCAT GGGGCCGCCA GTCCCCCCGA CGTCTGGAGG ACTCAAGCAA TGGAGAGCGG 
CGAGCATGCT GGGCTTGGGG TCCCAGTTCC CCCAAGCCTG GGGAAGCCCA GAATGGGAGG 
AGAAGGTCCC GCATGGACGA AGCCACATGG TACCTGGATT CAGATGACTC ATCCCCCTTA 
GGATCTCCTT CCACACCCCC AGCACTCAAT GGTAACCCCC CGCGGCCTAG CCTGGAGCCC 
GAGGAGCCCA AGAGGCCTGT CCCCGCAGAG CGCGGTAGCA GCTCTGGGAC GCCCAAGCTG 
ATCCAGCGGG CGCTGCTGCG CGGCACCGCC CTGCTCGCCT CGCTGGGCCT TGGCCGCGAC 
CTGCAGCCGC CGGGAGGCCC AGGACGCGAG CGCGGGGAGT CCCCGACAAC ACCCCCCACG 
CCAACGCCCG CGCCCTGCCC GACCGAGCCG CCCCCTTCCC CGCTCATCTG CTTCTCGCTC 
AAGACGCCCG ACTCCCCGCC CACTCCTGCA CCCCTGTTGC TGGACCTGGG TATCCCTGTG 
GGCCAGCGGT CAGCCAAGAG CCCCCGACGT GAGGAGGAGC CCCGCGGAGG CACTGTCTCA 
CCCCCACCGG GGACATCACG CTCTGCTCCT GGCACCCCAG GCACCCCACG TTCACCACCC 
CTGGGCCTCA TCAGCCGACC TCGGCCCTCG CCCCTTCGCA GCCGCATTGA TCCCTGGAGC 
TTTGTGTCAG CTGGGCCACG GCCTTCTCCC CTGCCATCAC CACAGCCTGC ACCCCGCCGA 
GCACCCTGGA CCTTGTTCCC GGACTCAGAC CCCTTCTGGG ACTCCCCACC TGCCAACCCC 
TTCCAGGGGG GCCCCCAGGA CTGCAGGGCA CAGACCAAAG ACATGGGTGC CCAGGCCCCG 
TGGGTGCCGG AAGCGGGGCC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mixed lineage kinase 3 promotes breast tumorigenesis via phosphorylation and activation of p21-activated kinase 1.
Oncogene38(19)3569-3584(2019 05)
Das S,Nair RS,Mishra R,Sondarva G,Viswakarma N,Abdelkarim H,Gaponenko V,Rana B,Rana A

IFN-γ-inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5.
Science signaling11(557)(2018 11)
Saleiro D,Blyth GT,Kosciuczuk EM,Ozark PA,Majchrzak-Kita B,Arslan AD,Fischietti M,Reddy NK,Horvath CM,Davis RJ,Fish EN,Platanias LC

Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3.
The Journal of biological chemistry293(35)13553-13565(2018 08)
Kokoszka ME,Kall SL,Khosla S,McGinnis JE,Lavie A,Kay BK

A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy.
BMC medical genomics11(1)22(2018 03)
Silva CT,Zorkoltseva IV,Niemeijer MN,van den Berg ME,Amin N,Demirkan A,van Leeuwen E,Iglesias AI,Piñeros-Hernández LB,Restrepo CM,Kors JA,Kirichenko AV,Willemsen R,Oostra BA,Stricker BH,Uitterlinden AG,Axenovich TI,van Duijn CM,Isaacs A

MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells.
Oncogene37(8)1031-1040(2018 02)
Schroyer AL,Stimes NW,Abi Saab WF,Chadee DN

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MAP3K11 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

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