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Home » Gene Synthesis & Molecular Biology Services » ORF » Hot Human pathways » Class I MHC mediated antigen processing

Overview

About the Class I MHC mediated antigen processing & presentation pathway

Major histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular bacteria or tumor-associated antigens. They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell surface.

The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.

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Gene Symbol Full Name
B2M beta-2-microglobulin
BLMH bleomycin hydrolase
CALR calreticulin
CANX calnexin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDC27 cell division cycle 27
CDC34 cell division cycle 34
CTSL cathepsin L
CTSV cathepsin V
CTSS cathepsin S
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
PDIA3 protein disulfide isomerase family A, member 3
UBE2K ubiquitin-conjugating enzyme E2K
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
ITGAV integrin, alpha V
ITGB5 integrin, beta 5
LNPEP leucyl/cystinyl aminopeptidase
MRC1 mannose receptor, C type 1
TRIM37 tripartite motif containing 37
NCF2 neutrophil cytosolic factor 2
NCF4 neutrophil cytosolic factor 4, 40kDa
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
PARK2 parkin RBR E3 ubiquitin protein ligase
PSMA1 proteasome subunit alpha 1
PSMA2 proteasome subunit alpha 2
PSMA3 proteasome subunit alpha 3
PSMA4 proteasome subunit alpha 4
PSMA5 proteasome subunit alpha 5
PSMA6 proteasome subunit alpha 6
PSMA7 proteasome subunit alpha 7
PSMB1 proteasome subunit beta 1
PSMB2 proteasome subunit beta 2
PSMB3 proteasome subunit beta 3
PSMB4 proteasome subunit beta 4
PSMB5 proteasome subunit beta 5
PSMB6 proteasome subunit beta 6
PSMB7 proteasome subunit beta 7
PSMB8 proteasome subunit beta 8
PSMB9 proteasome subunit beta 9
PSMB10 proteasome subunit beta 10
PSMC1 proteasome 26S subunit, ATPase 1
PSMC2 proteasome 26S subunit, ATPase 2
PSMC3 proteasome 26S subunit, ATPase 3
PSMC4 proteasome 26S subunit, ATPase 4
PSMC5 proteasome 26S subunit, ATPase 5
PSMC6 proteasome 26S subunit, ATPase 6
PSMD1 proteasome 26S subunit, non-ATPase 1
PSMD2 proteasome 26S subunit, non-ATPase 2
PSMD3 proteasome 26S subunit, non-ATPase 3
PSMD4 proteasome 26S subunit, non-ATPase 4
PSMD5 proteasome 26S subunit, non-ATPase 5
PSMD7 proteasome 26S subunit, non-ATPase 7
PSMD8 proteasome 26S subunit, non-ATPase 8
PSMD9 proteasome 26S subunit, non-ATPase 9
PSMD10 proteasome 26S subunit, non-ATPase 10
PSMD11 proteasome 26S subunit, non-ATPase 11
PSMD12 proteasome 26S subunit, non-ATPase 12
PSMD13 proteasome 26S subunit, non-ATPase 13
PSME1 proteasome activator subunit 1
PSME2 proteasome activator subunit 2
RNF4 ring finger protein 4
RNF6 ring finger protein (C3H2C3 type) 6
RPS27A ribosomal protein S27a
SEC13 SEC13 homolog, nuclear pore and COPII coat complex component
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
TRIM21 tripartite motif containing 21
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TPP2 tripeptidyl peptidase II
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBA1 ubiquitin-like modifier activating enzyme 1
UBA7 ubiquitin-like modifier activating enzyme 7
UBE2A ubiquitin-conjugating enzyme E2A
UBE2B ubiquitin-conjugating enzyme E2B
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2E2 ubiquitin-conjugating enzyme E2E 2
UBE2G1 ubiquitin-conjugating enzyme E2G 1
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBE2H ubiquitin-conjugating enzyme E2H
UBE2L3 ubiquitin-conjugating enzyme E2L 3

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