| Gene Symbol | NEDD4 |
| Entrez Gene ID | 4734 |
| Full Name | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase |
| Synonyms | NEDD4-1,RPF1 |
| General protein information |
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| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]. |
| Disorder MIM: |

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