| Gene Symbol | PSMB6 |
| Entrez Gene ID | 5694 |
| Full Name | proteasome subunit beta 6 |
| Synonyms | DELTA,LMPY,Y |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]. |
| Disorder MIM: |
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PSMB6 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following PSMB6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSMB6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu09774 Clone ID Related Accession (Same CDS sequence) NM_001270481.1 Accession Version NM_001270481.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 642bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577376000000 Organism Homo sapiens(human) Product proteasome subunit beta type-6 isoform 2 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF671774.1, BU848746.1 and BM553399.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. It is not known whether this isoform (2) is proteolytically processed in the same manner as isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU848746.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMEA2149398 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601ATGGCGGCTA CCTTACTAGC TGCTCGGGGA GCCGGGCCAG CACCGGCTTG GGGGCCGGAG
GCGTTCACTC CAGACTGGGA AAGCCGAGAA GTTTCCACTG GGACCACTAT CATGGCCGTG
CAGTTTGACG GGGGCGTGGT TCTGGGGGCG GACTCCAGAA CAACCACTGG GTCCTACATC
GCCAATCGAG TGACTGACAA GCTGACACCT ATTCACGACC GCATTTTCTG CTGTCGCTCA
GGCTCAGCTG CTGATACCCA GGCAGTAGCT GATGCTGTCA CCTACCAGCT CGGTTTCCAC
AGCATTGAAC TGAATGAGCC TCCACTGGTC CACACAGCAG CCAGCCTCTT TAAGGAGATG
TGTTACCGAT ACCGGGAAGA CCTGATGGCG GGAATCATCA TCGCAGGCTG GGACCCTCAA
GAAGGAGGGC AGGTGTACTC AGTGCCTATG GGGGGTATGA TGGTAAGGCA GTCCTTTGCC
ATTGGAGGCT CCGGGAGCTC CTACATCTAT GGCTATGTTG ATGCTACCTA CCGGGAAGGC
ATGACCAAGG AAGAGTGTCT GCAATTCACT GCCAATGCTT TCTTCTTTTA TCCACAGCTC
TCGCTTTGGC CATGGAGCGG GATGGCTCCA GTGGAGGAGT GAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001257410.1 CDS 52..693 Translation 
Target ORF information:
RefSeq Version NM_001270481.1 Organism Homo sapiens(human) Definition Homo sapiens proteasome 20S subunit beta 6 (PSMB6), transcript variant 2, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_001270481.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601ATGGCGGCTA CCTTACTAGC TGCTCGGGGA GCCGGGCCAG CACCGGCTTG GGGGCCGGAG
GCGTTCACTC CAGACTGGGA AAGCCGAGAA GTTTCCACTG GGACCACTAT CATGGCCGTG
CAGTTTGACG GGGGCGTGGT TCTGGGGGCG GACTCCAGAA CAACCACTGG GTCCTACATC
GCCAATCGAG TGACTGACAA GCTGACACCT ATTCACGACC GCATTTTCTG CTGTCGCTCA
GGCTCAGCTG CTGATACCCA GGCAGTAGCT GATGCTGTCA CCTACCAGCT CGGTTTCCAC
AGCATTGAAC TGAATGAGCC TCCACTGGTC CACACAGCAG CCAGCCTCTT TAAGGAGATG
TGTTACCGAT ACCGGGAAGA CCTGATGGCG GGAATCATCA TCGCAGGCTG GGACCCTCAA
GAAGGAGGGC AGGTGTACTC AGTGCCTATG GGGGGTATGA TGGTAAGGCA GTCCTTTGCC
ATTGGAGGCT CCGGGAGCTC CTACATCTAT GGCTATGTTG ATGCTACCTA CCGGGAAGGC
ATGACCAAGG AAGAGTGTCT GCAATTCACT GCCAATGCTT TCTTCTTTTA TCCACAGCTC
TCGCTTTGGC CATGGAGCGG GATGGCTCCA GTGGAGGAGT GAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu09574 Clone ID Related Accession (Same CDS sequence) NM_002798.2 , NM_002798.3 Accession Version NM_002798.2 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 720bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1506787200000 Organism Homo sapiens(human) Product proteasome subunit beta type-6 isoform 1 precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF671774.1, BC000835.2 and BM553399.1. On Jul 11, 2012 this sequence version replaced NM_002798.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.257975.1, CD051012.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661ATGGCGGCTA CCTTACTAGC TGCTCGGGGA GCCGGGCCAG CACCGGCTTG GGGGCCGGAG
GCGTTCACTC CAGACTGGGA AAGCCGAGAA GTTTCCACTG GGACCACTAT CATGGCCGTG
CAGTTTGACG GGGGCGTGGT TCTGGGGGCG GACTCCAGAA CAACCACTGG GTCCTACATC
GCCAATCGAG TGACTGACAA GCTGACACCT ATTCACGACC GCATTTTCTG CTGTCGCTCA
GGCTCAGCTG CTGATACCCA GGCAGTAGCT GATGCTGTCA CCTACCAGCT CGGTTTCCAC
AGCATTGAAC TGAATGAGCC TCCACTGGTC CACACAGCAG CCAGCCTCTT TAAGGAGATG
TGTTACCGAT ACCGGGAAGA CCTGATGGCG GGAATCATCA TCGCAGGCTG GGACCCTCAA
GAAGGAGGGC AGGTGTACTC AGTGCCTATG GGGGGTATGA TGGTAAGGCA GTCCTTTGCC
ATTGGAGGCT CCGGGAGCTC CTACATCTAT GGCTATGTTG ATGCTACCTA CCGGGAAGGC
ATGACCAAGG AAGAGTGTCT GCAATTCACT GCCAATGCTC TCGCTTTGGC CATGGAGCGG
GATGGCTCCA GTGGAGGAGT GATCCGCCTG GCAGCCATTG CAGAGTCAGG GGTAGAGCGG
CAAGTACTTT TGGGAGACCA GATACCCAAA TTCGCCGTTG CCACTTTACC ACCCGCCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_002789.1 CDS 52..771 Translation
Target ORF information:
RefSeq Version NM_002798.2 Organism Homo sapiens(human) Definition Homo sapiens proteasome subunit beta 6 (PSMB6), transcript variant 1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_002798.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661ATGGCGGCTA CCTTACTAGC TGCTCGGGGA GCCGGGCCAG CACCGGCTTG GGGGCCGGAG
GCGTTCACTC CAGACTGGGA AAGCCGAGAA GTTTCCACTG GGACCACTAT CATGGCCGTG
CAGTTTGACG GGGGCGTGGT TCTGGGGGCG GACTCCAGAA CAACCACTGG GTCCTACATC
GCCAATCGAG TGACTGACAA GCTGACACCT ATTCACGACC GCATTTTCTG CTGTCGCTCA
GGCTCAGCTG CTGATACCCA GGCAGTAGCT GATGCTGTCA CCTACCAGCT CGGTTTCCAC
AGCATTGAAC TGAATGAGCC TCCACTGGTC CACACAGCAG CCAGCCTCTT TAAGGAGATG
TGTTACCGAT ACCGGGAAGA CCTGATGGCG GGAATCATCA TCGCAGGCTG GGACCCTCAA
GAAGGAGGGC AGGTGTACTC AGTGCCTATG GGGGGTATGA TGGTAAGGCA GTCCTTTGCC
ATTGGAGGCT CCGGGAGCTC CTACATCTAT GGCTATGTTG ATGCTACCTA CCGGGAAGGC
ATGACCAAGG AAGAGTGTCT GCAATTCACT GCCAATGCTC TCGCTTTGGC CATGGAGCGG
GATGGCTCCA GTGGAGGAGT GATCCGCCTG GCAGCCATTG CAGAGTCAGG GGTAGAGCGG
CAAGTACTTT TGGGAGACCA GATACCCAAA TTCGCCGTTG CCACTTTACC ACCCGCCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu09574 Clone ID Related Accession (Same CDS sequence) NM_002798.2 , NM_002798.3 Accession Version NM_002798.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 720bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577808000000 Organism Homo sapiens(human) Product proteasome subunit beta type-6 isoform 1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF671774.1 and BC000835.2. On Nov 23, 2018 this sequence version replaced NM_002798.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.44608.1, SRR5189661.178261.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000270586.8/ ENSP00000270586.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661ATGGCGGCTA CCTTACTAGC TGCTCGGGGA GCCGGGCCAG CACCGGCTTG GGGGCCGGAG
GCGTTCACTC CAGACTGGGA AAGCCGAGAA GTTTCCACTG GGACCACTAT CATGGCCGTG
CAGTTTGACG GGGGCGTGGT TCTGGGGGCG GACTCCAGAA CAACCACTGG GTCCTACATC
GCCAATCGAG TGACTGACAA GCTGACACCT ATTCACGACC GCATTTTCTG CTGTCGCTCA
GGCTCAGCTG CTGATACCCA GGCAGTAGCT GATGCTGTCA CCTACCAGCT CGGTTTCCAC
AGCATTGAAC TGAATGAGCC TCCACTGGTC CACACAGCAG CCAGCCTCTT TAAGGAGATG
TGTTACCGAT ACCGGGAAGA CCTGATGGCG GGAATCATCA TCGCAGGCTG GGACCCTCAA
GAAGGAGGGC AGGTGTACTC AGTGCCTATG GGGGGTATGA TGGTAAGGCA GTCCTTTGCC
ATTGGAGGCT CCGGGAGCTC CTACATCTAT GGCTATGTTG ATGCTACCTA CCGGGAAGGC
ATGACCAAGG AAGAGTGTCT GCAATTCACT GCCAATGCTC TCGCTTTGGC CATGGAGCGG
GATGGCTCCA GTGGAGGAGT GATCCGCCTG GCAGCCATTG CAGAGTCAGG GGTAGAGCGG
CAAGTACTTT TGGGAGACCA GATACCCAAA TTCGCCGTTG CCACTTTACC ACCCGCCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_002789.1 CDS 32..751 Translation
Target ORF information:
RefSeq Version NM_002798.3 Organism Homo sapiens(human) Definition Homo sapiens proteasome 20S subunit beta 6 (PSMB6), transcript variant 1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_002798.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661ATGGCGGCTA CCTTACTAGC TGCTCGGGGA GCCGGGCCAG CACCGGCTTG GGGGCCGGAG
GCGTTCACTC CAGACTGGGA AAGCCGAGAA GTTTCCACTG GGACCACTAT CATGGCCGTG
CAGTTTGACG GGGGCGTGGT TCTGGGGGCG GACTCCAGAA CAACCACTGG GTCCTACATC
GCCAATCGAG TGACTGACAA GCTGACACCT ATTCACGACC GCATTTTCTG CTGTCGCTCA
GGCTCAGCTG CTGATACCCA GGCAGTAGCT GATGCTGTCA CCTACCAGCT CGGTTTCCAC
AGCATTGAAC TGAATGAGCC TCCACTGGTC CACACAGCAG CCAGCCTCTT TAAGGAGATG
TGTTACCGAT ACCGGGAAGA CCTGATGGCG GGAATCATCA TCGCAGGCTG GGACCCTCAA
GAAGGAGGGC AGGTGTACTC AGTGCCTATG GGGGGTATGA TGGTAAGGCA GTCCTTTGCC
ATTGGAGGCT CCGGGAGCTC CTACATCTAT GGCTATGTTG ATGCTACCTA CCGGGAAGGC
ATGACCAAGG AAGAGTGTCT GCAATTCACT GCCAATGCTC TCGCTTTGGC CATGGAGCGG
GATGGCTCCA GTGGAGGAGT GATCCGCCTG GCAGCCATTG CAGAGTCAGG GGTAGAGCGG
CAAGTACTTT TGGGAGACCA GATACCCAAA TTCGCCGTTG CCACTTTACC ACCCGCCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R
Sequence analysis of β-subunit genes of the 20S proteasome in patients with relapsed multiple myeloma treated with bortezomib or dexamethasone.
Blood120(23)4513-6(2012 Nov)
Lichter DI,Danaee H,Pickard MD,Tayber O,Sintchak M,Shi H,Richardson PG,Cavenagh J,Bladé J,Façon T,Niesvizky R,Alsina M,Dalton W,Sonneveld P,Lonial S,van de Velde H,Ricci D,Esseltine DL,Trepicchio WL,Mulligan G,Anderson KC
Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballescà JL,Oliva R
Evaluation of Zinc-α-2-Glycoprotein and Proteasome Subunit β-Type 6 Expression in Prostate Cancer Using Tissue Microarray Technology.
Applied immunohistochemistry & molecular morphology : AIMM18(6)512-7(2010 Dec)
O'Hurley G,O'Grady A,Smyth P,Byrne J,O'Leary JJ,Sheils O,William R,Watson G,Kay EW
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