CTSS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CTSS
Entrez Gene ID	1520
Full Name	cathepsin S
General protein information	Preferred Names cathepsin S Names cathepsin S
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010].
Disorder MIM:	116845

mRNA and Protein(s)

mRNA	Protein	Name
NM_004079.4	NP_004070.3	cathepsin S isoform 1 preproprotein
NM_004079.5	NP_004070.3	cathepsin S isoform 1 preproprotein
NM_001199739.2	NP_001186668.1	cathepsin S isoform 2 preproprotein
NM_001199739.1	NP_001186668.1	cathepsin S isoform 2 preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CTSS	XP_001171268.1
Mus musculus (house mouse)	Ctss	NP_067256.4
Gallus gallus (chicken)	CTSS	NP_001026516.1
Danio rerio (zebrafish)	ctssb.1	NP_001019580.2
Arabidopsis thaliana (thale cress)	AT4G11320	NP_567377.1
Homo sapiens (human)	CTSS	NP_004070.3
Canis lupus familiaris (dog)	CTSS	NP_001002938.2
Arabidopsis thaliana (thale cress)	AT4G11310	NP_567376.1
Bos taurus (cattle)	CTSS	NP_001028787.1
Rattus norvegicus (Norway rat)	Ctss	NP_059016.1
Danio rerio (zebrafish)	ctssb.2	NP_001017661.1
Xenopus tropicalis (tropical clawed frog)	ctss	NP_001005695.1
Macaca mulatta (Rhesus monkey)	LOC708080	XP_002801809.1
Arabidopsis thaliana (thale cress)	AT4G23520	NP_567686.2

Gene Ontology
Bibliography

Related articles in PubMed

[The association between Cathepsin S and pulmonary function and CT phenotypes in patients with chronic obstructive pulmonary disease].
Wu KY, Zhu Z, Wang Y, Yin SJ, Li GY, Kong ZB, Liu Y, Li H, Song S, Liu H
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases42(5)372-377(2019 May)

Elevated circulating cathepsin S levels are associated with metabolic syndrome in overweight and obese individuals.
Chen L, Lu B, Yang Y, Zhang W, Wang X, Zhou H, Wen J, Yang Z, Hu R
Diabetes/metabolism research and reviews35(3)e3117(2019 03)

Acute phase serum cathepsin S level and cathepsin S/cystatin C ratio are the associated factors with cerebral infarction and their diagnostic value for cerebral infarction.
Zhang AW, Han XS, Xu XT, Fang YN, Chen HB, Jiang T
The Kaohsiung journal of medical sciences35(2)95-101(2019 Feb)

Association between CTSS gene polymorphism and the risk of acute atherosclerotic cerebral infarction in Chinese population: a case-control study.
Luo L, Zhu M, Zhou J
Bioscience reports38(6)(2018 12)

Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells.
Klinngam W, Fu R, Janga SR, Edman MC, Hamm-Alvarez SF
International journal of molecular sciences19(11)(2018 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CTSS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CTSS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22314	NM_001199739.2 Latest version!	Homo sapiens cathepsin S (CTSS), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu22958	NM_004079.5 Latest version!	Homo sapiens cathepsin S (CTSS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu22958	NM_004079.4	Homo sapiens cathepsin S (CTSS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu22314	NM_001199739.1	Homo sapiens cathepsin S (CTSS), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CTSS ( NM_001199739.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186668.1 Homo sapiens cathepsin S (CTSS), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu22314
Clone ID Related Accession (Same CDS sequence)	NM_001199739.2 , NM_001199739.1
Accession Version	NM_001199739.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 846bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565539200000
Organism	Homo sapiens(human)
Product	cathepsin S isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL356292.21 and AK301472.1. On May 31, 2019 this sequence version replaced NM_001199739.1. Transcript Variant: This variant (2) lacks an in-frame exon in the CDS, so encodes a shorter isoform (2), as compared to variant 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK301472.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820693 [ECO:0000348] ##Evidence-Data-END##

ATGAAACGGC TGGTTTGTGT GCTCTTGGTG TGCTCCTCTG CAGTGGCACA GTTGCATAAA 
GATCCTACCC TGGATCACCA CTGGCATCTC TGGAAGAAAA CCTATGGCAA ACAATACAAG 
GAAAAGAATG AAGAAGCAGT ACGACGTCTC ATCTGGGAAA AGAATCTAAA GTTTGTGATG 
CTTCACAACC TGGAGCATTC AATGGGAATG CACTCATACG ATCTGGGCAT GAACCACCTG 
GGAGACATGG GTTCTTGTGG TGCTTGCTGG GCTTTCAGTG CTGTGGGGGC CCTGGAAGCA 
CAGCTGAAGC TGAAAACAGG AAAGCTGGTG TCTCTCAGTG CCCAGAACCT GGTGGATTGC 
TCAACTGAAA AATATGGAAA CAAAGGCTGC AATGGTGGCT TCATGACAAC GGCTTTCCAG 
TACATCATTG ATAACAAGGG CATCGACTCA GACGCTTCCT ATCCCTACAA AGCCATGGAT 
CAGAAATGTC AATATGACTC AAAATATCGT GCTGCCACAT GTTCAAAGTA CACTGAACTT 
CCTTATGGCA GAGAAGATGT CCTGAAAGAA GCTGTGGCCA ATAAAGGCCC AGTGTCTGTT 
GGTGTAGATG CGCGTCATCC TTCTTTCTTC CTCTACAGAA GTGGTGTCTA CTATGAACCA 
TCCTGTACTC AGAATGTGAA TCATGGTGTA CTTGTGGTTG GCTATGGTGA TCTTAATGGG 
AAAGAATACT GGCTTGTGAA AAACAGCTGG GGCCACAACT TTGGTGAAGA AGGATATATT 
CGGATGGCAA GAAATAAAGG AAATCATTGT GGGATTGCTA GCTTTCCCTC TTACCCAGAA 
ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186668.1
CDS	83..928
Translation	MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI

Target ORF information:

RefSeq Version	NM_001199739.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cathepsin S (CTSS), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199739.2

ORF Insert Sequence:

ATGAAACGGC TGGTTTGTGT GCTCTTGGTG TGCTCCTCTG CAGTGGCACA GTTGCATAAA 
GATCCTACCC TGGATCACCA CTGGCATCTC TGGAAGAAAA CCTATGGCAA ACAATACAAG 
GAAAAGAATG AAGAAGCAGT ACGACGTCTC ATCTGGGAAA AGAATCTAAA GTTTGTGATG 
CTTCACAACC TGGAGCATTC AATGGGAATG CACTCATACG ATCTGGGCAT GAACCACCTG 
GGAGACATGG GTTCTTGTGG TGCTTGCTGG GCTTTCAGTG CTGTGGGGGC CCTGGAAGCA 
CAGCTGAAGC TGAAAACAGG AAAGCTGGTG TCTCTCAGTG CCCAGAACCT GGTGGATTGC 
TCAACTGAAA AATATGGAAA CAAAGGCTGC AATGGTGGCT TCATGACAAC GGCTTTCCAG 
TACATCATTG ATAACAAGGG CATCGACTCA GACGCTTCCT ATCCCTACAA AGCCATGGAT 
CAGAAATGTC AATATGACTC AAAATATCGT GCTGCCACAT GTTCAAAGTA CACTGAACTT 
CCTTATGGCA GAGAAGATGT CCTGAAAGAA GCTGTGGCCA ATAAAGGCCC AGTGTCTGTT 
GGTGTAGATG CGCGTCATCC TTCTTTCTTC CTCTACAGAA GTGGTGTCTA CTATGAACCA 
TCCTGTACTC AGAATGTGAA TCATGGTGTA CTTGTGGTTG GCTATGGTGA TCTTAATGGG 
AAAGAATACT GGCTTGTGAA AAACAGCTGG GGCCACAACT TTGGTGAAGA AGGATATATT 
CGGATGGCAA GAAATAAAGG AAATCATTGT GGGATTGCTA GCTTTCCCTC TTACCCAGAA 
ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSS ( NM_001199739.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186668.1 Homo sapiens cathepsin S (CTSS), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu22314
Clone ID Related Accession (Same CDS sequence)	NM_001199739.2 , NM_001199739.1
Accession Version	NM_001199739.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 846bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1551542400000
Organism	Homo sapiens(human)
Product	cathepsin S isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL356292.21 and AK301472.1. Transcript Variant: This variant (2) lacks an in-frame exon in the CDS, so encodes a shorter isoform (2), as compared to variant 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK301472.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820693 [ECO:0000348] ##Evidence-Data-END##

ATGAAACGGC TGGTTTGTGT GCTCTTGGTG TGCTCCTCTG CAGTGGCACA GTTGCATAAA 
GATCCTACCC TGGATCACCA CTGGCATCTC TGGAAGAAAA CCTATGGCAA ACAATACAAG 
GAAAAGAATG AAGAAGCAGT ACGACGTCTC ATCTGGGAAA AGAATCTAAA GTTTGTGATG 
CTTCACAACC TGGAGCATTC AATGGGAATG CACTCATACG ATCTGGGCAT GAACCACCTG 
GGAGACATGG GTTCTTGTGG TGCTTGCTGG GCTTTCAGTG CTGTGGGGGC CCTGGAAGCA 
CAGCTGAAGC TGAAAACAGG AAAGCTGGTG TCTCTCAGTG CCCAGAACCT GGTGGATTGC 
TCAACTGAAA AATATGGAAA CAAAGGCTGC AATGGTGGCT TCATGACAAC GGCTTTCCAG 
TACATCATTG ATAACAAGGG CATCGACTCA GACGCTTCCT ATCCCTACAA AGCCATGGAT 
CAGAAATGTC AATATGACTC AAAATATCGT GCTGCCACAT GTTCAAAGTA CACTGAACTT 
CCTTATGGCA GAGAAGATGT CCTGAAAGAA GCTGTGGCCA ATAAAGGCCC AGTGTCTGTT 
GGTGTAGATG CGCGTCATCC TTCTTTCTTC CTCTACAGAA GTGGTGTCTA CTATGAACCA 
TCCTGTACTC AGAATGTGAA TCATGGTGTA CTTGTGGTTG GCTATGGTGA TCTTAATGGG 
AAAGAATACT GGCTTGTGAA AAACAGCTGG GGCCACAACT TTGGTGAAGA AGGATATATT 
CGGATGGCAA GAAATAAAGG AAATCATTGT GGGATTGCTA GCTTTCCCTC TTACCCAGAA 
ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186668.1
CDS	262..1107
Translation	MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI

Target ORF information:

RefSeq Version	NM_001199739.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cathepsin S (CTSS), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199739.1

ORF Insert Sequence:

ATGAAACGGC TGGTTTGTGT GCTCTTGGTG TGCTCCTCTG CAGTGGCACA GTTGCATAAA 
GATCCTACCC TGGATCACCA CTGGCATCTC TGGAAGAAAA CCTATGGCAA ACAATACAAG 
GAAAAGAATG AAGAAGCAGT ACGACGTCTC ATCTGGGAAA AGAATCTAAA GTTTGTGATG 
CTTCACAACC TGGAGCATTC AATGGGAATG CACTCATACG ATCTGGGCAT GAACCACCTG 
GGAGACATGG GTTCTTGTGG TGCTTGCTGG GCTTTCAGTG CTGTGGGGGC CCTGGAAGCA 
CAGCTGAAGC TGAAAACAGG AAAGCTGGTG TCTCTCAGTG CCCAGAACCT GGTGGATTGC 
TCAACTGAAA AATATGGAAA CAAAGGCTGC AATGGTGGCT TCATGACAAC GGCTTTCCAG 
TACATCATTG ATAACAAGGG CATCGACTCA GACGCTTCCT ATCCCTACAA AGCCATGGAT 
CAGAAATGTC AATATGACTC AAAATATCGT GCTGCCACAT GTTCAAAGTA CACTGAACTT 
CCTTATGGCA GAGAAGATGT CCTGAAAGAA GCTGTGGCCA ATAAAGGCCC AGTGTCTGTT 
GGTGTAGATG CGCGTCATCC TTCTTTCTTC CTCTACAGAA GTGGTGTCTA CTATGAACCA 
TCCTGTACTC AGAATGTGAA TCATGGTGTA CTTGTGGTTG GCTATGGTGA TCTTAATGGG 
AAAGAATACT GGCTTGTGAA AAACAGCTGG GGCCACAACT TTGGTGAAGA AGGATATATT 
CGGATGGCAA GAAATAAAGG AAATCATTGT GGGATTGCTA GCTTTCCCTC TTACCCAGAA 
ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSS ( NM_004079.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004070.3 Homo sapiens cathepsin S (CTSS), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22958
Clone ID Related Accession (Same CDS sequence)	NM_004079.4 , NM_004079.5
Accession Version	NM_004079.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 996bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1512835200000
Organism	Homo sapiens(human)
Product	cathepsin S isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL356292.21, M90696.1 and BC002642.2. On Dec 15, 2010 this sequence version replaced NM_004079.3. Transcript Variant: This variant (1) encodes a longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.236689.1, SRR1803617.173832.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAACGGC TGGTTTGTGT GCTCTTGGTG TGCTCCTCTG CAGTGGCACA GTTGCATAAA 
GATCCTACCC TGGATCACCA CTGGCATCTC TGGAAGAAAA CCTATGGCAA ACAATACAAG 
GAAAAGAATG AAGAAGCAGT ACGACGTCTC ATCTGGGAAA AGAATCTAAA GTTTGTGATG 
CTTCACAACC TGGAGCATTC AATGGGAATG CACTCATACG ATCTGGGCAT GAACCACCTG 
GGAGACATGA CCAGTGAAGA AGTGATGTCT TTGATGAGTT CCCTGAGAGT TCCCAGCCAG 
TGGCAGAGAA ATATCACATA TAAGTCAAAC CCTAATCGGA TATTGCCTGA TTCTGTGGAC 
TGGAGAGAGA AAGGGTGTGT TACTGAAGTG AAATATCAAG GTTCTTGTGG TGCTTGCTGG 
GCTTTCAGTG CTGTGGGGGC CCTGGAAGCA CAGCTGAAGC TGAAAACAGG AAAGCTGGTG 
TCTCTCAGTG CCCAGAACCT GGTGGATTGC TCAACTGAAA AATATGGAAA CAAAGGCTGC 
AATGGTGGCT TCATGACAAC GGCTTTCCAG TACATCATTG ATAACAAGGG CATCGACTCA 
GACGCTTCCT ATCCCTACAA AGCCATGGAT CAGAAATGTC AATATGACTC AAAATATCGT 
GCTGCCACAT GTTCAAAGTA CACTGAACTT CCTTATGGCA GAGAAGATGT CCTGAAAGAA 
GCTGTGGCCA ATAAAGGCCC AGTGTCTGTT GGTGTAGATG CGCGTCATCC TTCTTTCTTC 
CTCTACAGAA GTGGTGTCTA CTATGAACCA TCCTGTACTC AGAATGTGAA TCATGGTGTA 
CTTGTGGTTG GCTATGGTGA TCTTAATGGG AAAGAATACT GGCTTGTGAA AAACAGCTGG 
GGCCACAACT TTGGTGAAGA AGGATATATT CGGATGGCAA GAAATAAAGG AAATCATTGT 
GGGATTGCTA GCTTTCCCTC TTACCCAGAA ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004070.3
CDS	262..1257
Translation	MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI

Target ORF information:

RefSeq Version	NM_004079.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cathepsin S (CTSS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004079.4

ORF Insert Sequence:

ATGAAACGGC TGGTTTGTGT GCTCTTGGTG TGCTCCTCTG CAGTGGCACA GTTGCATAAA 
GATCCTACCC TGGATCACCA CTGGCATCTC TGGAAGAAAA CCTATGGCAA ACAATACAAG 
GAAAAGAATG AAGAAGCAGT ACGACGTCTC ATCTGGGAAA AGAATCTAAA GTTTGTGATG 
CTTCACAACC TGGAGCATTC AATGGGAATG CACTCATACG ATCTGGGCAT GAACCACCTG 
GGAGACATGA CCAGTGAAGA AGTGATGTCT TTGATGAGTT CCCTGAGAGT TCCCAGCCAG 
TGGCAGAGAA ATATCACATA TAAGTCAAAC CCTAATCGGA TATTGCCTGA TTCTGTGGAC 
TGGAGAGAGA AAGGGTGTGT TACTGAAGTG AAATATCAAG GTTCTTGTGG TGCTTGCTGG 
GCTTTCAGTG CTGTGGGGGC CCTGGAAGCA CAGCTGAAGC TGAAAACAGG AAAGCTGGTG 
TCTCTCAGTG CCCAGAACCT GGTGGATTGC TCAACTGAAA AATATGGAAA CAAAGGCTGC 
AATGGTGGCT TCATGACAAC GGCTTTCCAG TACATCATTG ATAACAAGGG CATCGACTCA 
GACGCTTCCT ATCCCTACAA AGCCATGGAT CAGAAATGTC AATATGACTC AAAATATCGT 
GCTGCCACAT GTTCAAAGTA CACTGAACTT CCTTATGGCA GAGAAGATGT CCTGAAAGAA 
GCTGTGGCCA ATAAAGGCCC AGTGTCTGTT GGTGTAGATG CGCGTCATCC TTCTTTCTTC 
CTCTACAGAA GTGGTGTCTA CTATGAACCA TCCTGTACTC AGAATGTGAA TCATGGTGTA 
CTTGTGGTTG GCTATGGTGA TCTTAATGGG AAAGAATACT GGCTTGTGAA AAACAGCTGG 
GGCCACAACT TTGGTGAAGA AGGATATATT CGGATGGCAA GAAATAAAGG AAATCATTGT 
GGGATTGCTA GCTTTCCCTC TTACCCAGAA ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSS ( NM_004079.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004070.3 Homo sapiens cathepsin S (CTSS), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22958
Clone ID Related Accession (Same CDS sequence)	NM_004079.4 , NM_004079.5
Accession Version	NM_004079.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 996bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565539200000
Organism	Homo sapiens(human)
Product	cathepsin S isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL356292.21, M90696.1 and BC002642.2. On Nov 22, 2018 this sequence version replaced NM_004079.4. Transcript Variant: This variant (1) encodes a longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.406276.1, SRR1803615.236689.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368985.8/ ENSP00000357981.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAACGGC TGGTTTGTGT GCTCTTGGTG TGCTCCTCTG CAGTGGCACA GTTGCATAAA 
GATCCTACCC TGGATCACCA CTGGCATCTC TGGAAGAAAA CCTATGGCAA ACAATACAAG 
GAAAAGAATG AAGAAGCAGT ACGACGTCTC ATCTGGGAAA AGAATCTAAA GTTTGTGATG 
CTTCACAACC TGGAGCATTC AATGGGAATG CACTCATACG ATCTGGGCAT GAACCACCTG 
GGAGACATGA CCAGTGAAGA AGTGATGTCT TTGATGAGTT CCCTGAGAGT TCCCAGCCAG 
TGGCAGAGAA ATATCACATA TAAGTCAAAC CCTAATCGGA TATTGCCTGA TTCTGTGGAC 
TGGAGAGAGA AAGGGTGTGT TACTGAAGTG AAATATCAAG GTTCTTGTGG TGCTTGCTGG 
GCTTTCAGTG CTGTGGGGGC CCTGGAAGCA CAGCTGAAGC TGAAAACAGG AAAGCTGGTG 
TCTCTCAGTG CCCAGAACCT GGTGGATTGC TCAACTGAAA AATATGGAAA CAAAGGCTGC 
AATGGTGGCT TCATGACAAC GGCTTTCCAG TACATCATTG ATAACAAGGG CATCGACTCA 
GACGCTTCCT ATCCCTACAA AGCCATGGAT CAGAAATGTC AATATGACTC AAAATATCGT 
GCTGCCACAT GTTCAAAGTA CACTGAACTT CCTTATGGCA GAGAAGATGT CCTGAAAGAA 
GCTGTGGCCA ATAAAGGCCC AGTGTCTGTT GGTGTAGATG CGCGTCATCC TTCTTTCTTC 
CTCTACAGAA GTGGTGTCTA CTATGAACCA TCCTGTACTC AGAATGTGAA TCATGGTGTA 
CTTGTGGTTG GCTATGGTGA TCTTAATGGG AAAGAATACT GGCTTGTGAA AAACAGCTGG 
GGCCACAACT TTGGTGAAGA AGGATATATT CGGATGGCAA GAAATAAAGG AAATCATTGT 
GGGATTGCTA GCTTTCCCTC TTACCCAGAA ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004070.3
CDS	83..1078
Translation	MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI

Target ORF information:

RefSeq Version	NM_004079.5
Organism	Homo sapiens(human)
Definition	Homo sapiens cathepsin S (CTSS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004079.5

ORF Insert Sequence:

ATGAAACGGC TGGTTTGTGT GCTCTTGGTG TGCTCCTCTG CAGTGGCACA GTTGCATAAA 
GATCCTACCC TGGATCACCA CTGGCATCTC TGGAAGAAAA CCTATGGCAA ACAATACAAG 
GAAAAGAATG AAGAAGCAGT ACGACGTCTC ATCTGGGAAA AGAATCTAAA GTTTGTGATG 
CTTCACAACC TGGAGCATTC AATGGGAATG CACTCATACG ATCTGGGCAT GAACCACCTG 
GGAGACATGA CCAGTGAAGA AGTGATGTCT TTGATGAGTT CCCTGAGAGT TCCCAGCCAG 
TGGCAGAGAA ATATCACATA TAAGTCAAAC CCTAATCGGA TATTGCCTGA TTCTGTGGAC 
TGGAGAGAGA AAGGGTGTGT TACTGAAGTG AAATATCAAG GTTCTTGTGG TGCTTGCTGG 
GCTTTCAGTG CTGTGGGGGC CCTGGAAGCA CAGCTGAAGC TGAAAACAGG AAAGCTGGTG 
TCTCTCAGTG CCCAGAACCT GGTGGATTGC TCAACTGAAA AATATGGAAA CAAAGGCTGC 
AATGGTGGCT TCATGACAAC GGCTTTCCAG TACATCATTG ATAACAAGGG CATCGACTCA 
GACGCTTCCT ATCCCTACAA AGCCATGGAT CAGAAATGTC AATATGACTC AAAATATCGT 
GCTGCCACAT GTTCAAAGTA CACTGAACTT CCTTATGGCA GAGAAGATGT CCTGAAAGAA 
GCTGTGGCCA ATAAAGGCCC AGTGTCTGTT GGTGTAGATG CGCGTCATCC TTCTTTCTTC 
CTCTACAGAA GTGGTGTCTA CTATGAACCA TCCTGTACTC AGAATGTGAA TCATGGTGTA 
CTTGTGGTTG GCTATGGTGA TCTTAATGGG AAAGAATACT GGCTTGTGAA AAACAGCTGG 
GGCCACAACT TTGGTGAAGA AGGATATATT CGGATGGCAA GAAATAAAGG AAATCATTGT 
GGGATTGCTA GCTTTCCCTC TTACCCAGAA ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

[The association between Cathepsin S and pulmonary function and CT phenotypes in patients with chronic obstructive pulmonary disease].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases42(5)372-377(2019 May)
Wu KY,Zhu Z,Wang Y,Yin SJ,Li GY,Kong ZB,Liu Y,Li H,Song S,Liu H

Elevated circulating cathepsin S levels are associated with metabolic syndrome in overweight and obese individuals.
Diabetes/metabolism research and reviews35(3)e3117(2019 03)
Chen L,Lu B,Yang Y,Zhang W,Wang X,Zhou H,Wen J,Yang Z,Hu R

Acute phase serum cathepsin S level and cathepsin S/cystatin C ratio are the associated factors with cerebral infarction and their diagnostic value for cerebral infarction.
The Kaohsiung journal of medical sciences35(2)95-101(2019 Feb)
Zhang AW,Han XS,Xu XT,Fang YN,Chen HB,Jiang T

Association between CTSS gene polymorphism and the risk of acute atherosclerotic cerebral infarction in Chinese population: a case-control study.
Bioscience reports38(6)(2018 12)
Luo L,Zhu M,Zhou J

Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells.
International journal of molecular sciences19(11)(2018 Nov)
Klinngam W,Fu R,Janga SR,Edman MC,Hamm-Alvarez SF

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CTSS cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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