PSMA6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSMA6
Entrez Gene ID	5687
Full Name	proteasome subunit alpha 6
Synonyms	IOTA,PROS27,p27K
General protein information	Preferred Names proteasome subunit alpha 6 Names proteasome subunit alpha type-6 27 kDa prosomal protein PROS-27 macropain iota chain macropain subunit iota multicatalytic endopeptidase complex iota chain prosomal P27K protein proteasome (prosome, macropain) subunit, alpha type, 6 proteasome iota chain proteasome subunit iota testicular secretory protein Li 44
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q13.2
Summary	The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013].
Disorder MIM:	602855
Disorder Html:	{Myocardial infarction, susceptibility to}, 608446 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017021468.1	XP_016876957.1	proteasome subunit alpha type-6 isoform X1
NM_001282232.1	NP_001269161.1	proteasome subunit alpha type-6 isoform b
NM_002791.3	NP_002782.1	proteasome subunit alpha type-6 isoform a
NM_002791.2	NP_002782.1	proteasome subunit alpha type-6 isoform a
NM_001282233.1	NP_001269162.1	proteasome subunit alpha type-6 isoform b
NM_001282234.1	NP_001269163.1	proteasome subunit alpha type-6 isoform c

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PSMA6	XP_537412.2
Saccharomyces cerevisiae (baker's yeast)	SCL1	NP_011504.3
Eremothecium gossypii	AGOS_AGL089W	NP_986577.1
Magnaporthe oryzae (rice blast fungus)	MGG_01153	XP_003717769.1
Kluyveromyces lactis	KLLA0A05027g	XP_451221.1
Macaca mulatta (Rhesus monkey)	PSMA6	XP_001095483.1
Mus musculus (house mouse)	Psma6	NP_036098.1
Drosophila melanogaster (fruit fly)	CG30382	NP_001163078.1
Xenopus tropicalis (tropical clawed frog)	psma6	NP_989113.1
Oryza sativa (rice)	Os03g0180400	NP_001049162.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003935	XP_318387.2
Macaca mulatta (Rhesus monkey)	PSMA6	XP_001086524.1
Gallus gallus (chicken)	PSMA6	NP_001264372.1
Arabidopsis thaliana (thale cress)	PAA1	NP_198409.1
Schizosaccharomyces pombe (fission yeast)	SPBC646.16	NP_595374.1
Bos taurus (cattle)	PSMA6	NP_001039427.1
Rattus norvegicus (Norway rat)	Psma6	NP_058979.1
Danio rerio (zebrafish)	zgc:92716	NP_001002589.1
Drosophila melanogaster (fruit fly)	Prosalpha1	NP_524837.2
Caenorhabditis elegans (roundworm)	pas-1	NP_506571.1
Arabidopsis thaliana (thale cress)	PAA2	NP_178641.1
Homo sapiens (human)	PSMA6	NP_002782.1
Pan troglodytes (chimpanzee)	PSMA6	NP_001233586.1
Neurospora crassa	NCU10061	XP_957907.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells.
Bakke J, Wright WC, Zamora AE, Oladimeji P, Crawford JC, Brewer CT, Autry RJ, Evans WE, Thomas PG, Chen T
BMC cancer19(1)253(2019 Mar)

Proteasome subunit-α type-6 protein is post-transcriptionally repressed by the microRNA-4490 in diabetic nephropathy.
Feng Y, Jin MY, Liu DW, Wei L
Bioscience reports38(5)(2018 10)

Identification of proteasomal catalytic subunit PSMA6 as a therapeutic target for lung cancer.
Kakumu T, Sato M, Goto D, Kato T, Yogo N, Hase T, Morise M, Fukui T, Yokoi K, Sekido Y, Girard L, Minna JD, Byers LA, Heymach JV, Coombes KR, Kondo M, Hasegawa Y
Cancer science108(4)732-743(2017 Apr)

Association between functional variant of inflammatory system gene (PSMA6) and end-stage kidney disease.
Buraczynska M, Stec A, Filipczak A, Ksiazek A
International urology and nephrology48(12)2083-2087(2016 Dec)

Hepatic expression of proteasome subunit alpha type-6 is upregulated during viral hepatitis and putatively regulates the expression of ISG15 ubiquitin-like modifier, a proviral host gene in hepatitis C virus infection.
Broering R, Trippler M, Werner M, Real CI, Megger DA, Bracht T, Schweinsberg V, Sitek B, Eisenacher M, Meyer HE, Baba HA, Weber F, Hoffmann AC, Gerken G, Schlaak JF
Journal of viral hepatitis23(5)375-86(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PSMA6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSMA6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04890	NM_001282234.1 Latest version!	Homo sapiens proteasome 20S subunit alpha 6 (PSMA6), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu04888	NM_001282232.1 Latest version!	Homo sapiens proteasome 20S subunit alpha 6 (PSMA6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu04888	NM_001282233.1 Latest version!	Homo sapiens proteasome 20S subunit alpha 6 (PSMA6), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu21602	NM_002791.3 Latest version!	Homo sapiens proteasome 20S subunit alpha 6 (PSMA6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu04888	XM_017021468.1 Latest version!	Homo sapiens proteasome 20S subunit alpha 6 (PSMA6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu21602	NM_002791.2	Homo sapiens proteasome subunit alpha 6 (PSMA6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSMA6 ( NM_001282234.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269163.1 Homo sapiens proteasome 20S subunit alpha 6 (PSMA6), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu04890
Clone ID Related Accession (Same CDS sequence)	NM_001282234.1
Accession Version	NM_001282234.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1567094400000
Organism	Homo sapiens(human)
Product	proteasome subunit alpha type-6 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA090836.1, HY028439.1, AK302008.1 and BQ009843.1. On Aug 24, 2013 this sequence version replaced XM_005267868.1. Transcript Variant: This variant (4) has an alternate first exon compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.61349.1, SRR1163658.468735.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGGTC TTCGGAGAGA ATATGCTTTT AAGGCTATTA ACCAGGGTGG CCTTACATCA 
GTAGCTGTCA GAGGGAAAGA CTGTGCAGTA ATTGTCACAC AGAAGAAAGT ACCTGACAAA 
TTATTGGATT CCAGCACAGT GACTCACTTA TTCAAGATAA CTGAAAACAT TGGTTGTGTG 
ATGACCGGAA TGACAGCTGA CAGCAGATCC CAGGTACAGA GGGCACGCTA TGAGGCAGCT 
AACTGGAAAT ACAAGTATGG CTATGAGATT CCTGTGGACA TGCTGTGTAA AAGAATTGCC 
GATATTTCTC AGGTCTACAC ACAGAATGCT GAAATGAGGC CTCTTGGTTG TTGTATGATT 
TTAATTGGTA TAGATGAAGA GCAAGGCCCT CAGGTATATA AGTGTGATCC TGCAGGTTAC 
TACTGTGGGT TTAAAGCCAC TGCAGCGGGA GTTAAACAAA CTGAGTCAAC CAGCTTCCTT 
GAAAAAAAAG TGAAGAAGAA ATTTGATTGG ACATTTGAAC AGACAGTGGA AACTGCAATT 
ACATGCCTGT CTACTGTTCT ATCAATTGAT TTCAAACCTT CAGAAATAGA AGTTGGAGTA 
GTGACAGTTG AAAATCCTAA ATTCAGGATT CTTACAGAAG CAGAGATTGA TGCTCACCTT 
GTTGCTCTAG CAGAGAGAGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269163.1
CDS	143..826
Translation	MAGLRREYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD

Target ORF information:

RefSeq Version	NM_001282234.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 20S subunit alpha 6 (PSMA6), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282234.1

ORF Insert Sequence:

ATGGCAGGTC TTCGGAGAGA ATATGCTTTT AAGGCTATTA ACCAGGGTGG CCTTACATCA 
GTAGCTGTCA GAGGGAAAGA CTGTGCAGTA ATTGTCACAC AGAAGAAAGT ACCTGACAAA 
TTATTGGATT CCAGCACAGT GACTCACTTA TTCAAGATAA CTGAAAACAT TGGTTGTGTG 
ATGACCGGAA TGACAGCTGA CAGCAGATCC CAGGTACAGA GGGCACGCTA TGAGGCAGCT 
AACTGGAAAT ACAAGTATGG CTATGAGATT CCTGTGGACA TGCTGTGTAA AAGAATTGCC 
GATATTTCTC AGGTCTACAC ACAGAATGCT GAAATGAGGC CTCTTGGTTG TTGTATGATT 
TTAATTGGTA TAGATGAAGA GCAAGGCCCT CAGGTATATA AGTGTGATCC TGCAGGTTAC 
TACTGTGGGT TTAAAGCCAC TGCAGCGGGA GTTAAACAAA CTGAGTCAAC CAGCTTCCTT 
GAAAAAAAAG TGAAGAAGAA ATTTGATTGG ACATTTGAAC AGACAGTGGA AACTGCAATT 
ACATGCCTGT CTACTGTTCT ATCAATTGAT TTCAAACCTT CAGAAATAGA AGTTGGAGTA 
GTGACAGTTG AAAATCCTAA ATTCAGGATT CTTACAGAAG CAGAGATTGA TGCTCACCTT 
GTTGCTCTAG CAGAGAGAGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMA6 ( NM_001282232.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269161.1 Homo sapiens proteasome 20S subunit alpha 6 (PSMA6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04888
Clone ID Related Accession (Same CDS sequence)	XM_017021468.1 , NM_001282232.1 , NM_001282233.1
Accession Version	NM_001282232.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1567094400000
Organism	Homo sapiens(human)
Product	proteasome subunit alpha type-6 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU657545.1, BG701535.1, BC002979.1, AK316223.1 and BQ009843.1. On Aug 24, 2013 this sequence version replaced XM_005267869.1. Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of the first exon compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (b) with a shorter N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK316223.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2145313 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCGGAA TGACAGCTGA CAGCAGATCC CAGGTACAGA GGGCACGCTA TGAGGCAGCT 
AACTGGAAAT ACAAGTATGG CTATGAGATT CCTGTGGACA TGCTGTGTAA AAGAATTGCC 
GATATTTCTC AGGTCTACAC ACAGAATGCT GAAATGAGGC CTCTTGGTTG TTGTATGATT 
TTAATTGGTA TAGATGAAGA GCAAGGCCCT CAGGTATATA AGTGTGATCC TGCAGGTTAC 
TACTGTGGGT TTAAAGCCAC TGCAGCGGGA GTTAAACAAA CTGAGTCAAC CAGCTTCCTT 
GAAAAAAAAG TGAAGAAGAA ATTTGATTGG ACATTTGAAC AGACAGTGGA AACTGCAATT 
ACATGCCTGT CTACTGTTCT ATCAATTGAT TTCAAACCTT CAGAAATAGA AGTTGGAGTA 
GTGACAGTTG AAAATCCTAA ATTCAGGATT CTTACAGAAG CAGAGATTGA TGCTCACCTT 
GTTGCTCTAG CAGAGAGAGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269161.1
CDS	446..949
Translation	MTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD

Target ORF information:

RefSeq Version	NM_001282232.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 20S subunit alpha 6 (PSMA6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282232.1

ORF Insert Sequence:

ATGACCGGAA TGACAGCTGA CAGCAGATCC CAGGTACAGA GGGCACGCTA TGAGGCAGCT 
AACTGGAAAT ACAAGTATGG CTATGAGATT CCTGTGGACA TGCTGTGTAA AAGAATTGCC 
GATATTTCTC AGGTCTACAC ACAGAATGCT GAAATGAGGC CTCTTGGTTG TTGTATGATT 
TTAATTGGTA TAGATGAAGA GCAAGGCCCT CAGGTATATA AGTGTGATCC TGCAGGTTAC 
TACTGTGGGT TTAAAGCCAC TGCAGCGGGA GTTAAACAAA CTGAGTCAAC CAGCTTCCTT 
GAAAAAAAAG TGAAGAAGAA ATTTGATTGG ACATTTGAAC AGACAGTGGA AACTGCAATT 
ACATGCCTGT CTACTGTTCT ATCAATTGAT TTCAAACCTT CAGAAATAGA AGTTGGAGTA 
GTGACAGTTG AAAATCCTAA ATTCAGGATT CTTACAGAAG CAGAGATTGA TGCTCACCTT 
GTTGCTCTAG CAGAGAGAGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMA6 ( NM_001282233.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269162.1 Homo sapiens proteasome 20S subunit alpha 6 (PSMA6), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu04888
Clone ID Related Accession (Same CDS sequence)	XM_017021468.1 , NM_001282232.1 , NM_001282233.1
Accession Version	NM_001282233.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1567094400000
Organism	Homo sapiens(human)
Product	proteasome subunit alpha type-6 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU657545.1, BG701535.1, AK298920.1 and BQ009843.1. On Aug 24, 2013 this sequence version replaced XM_005267870.1. Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (b) with a shorter N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298920.1, SRR1803615.261961.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCGGAA TGACAGCTGA CAGCAGATCC CAGGTACAGA GGGCACGCTA TGAGGCAGCT 
AACTGGAAAT ACAAGTATGG CTATGAGATT CCTGTGGACA TGCTGTGTAA AAGAATTGCC 
GATATTTCTC AGGTCTACAC ACAGAATGCT GAAATGAGGC CTCTTGGTTG TTGTATGATT 
TTAATTGGTA TAGATGAAGA GCAAGGCCCT CAGGTATATA AGTGTGATCC TGCAGGTTAC 
TACTGTGGGT TTAAAGCCAC TGCAGCGGGA GTTAAACAAA CTGAGTCAAC CAGCTTCCTT 
GAAAAAAAAG TGAAGAAGAA ATTTGATTGG ACATTTGAAC AGACAGTGGA AACTGCAATT 
ACATGCCTGT CTACTGTTCT ATCAATTGAT TTCAAACCTT CAGAAATAGA AGTTGGAGTA 
GTGACAGTTG AAAATCCTAA ATTCAGGATT CTTACAGAAG CAGAGATTGA TGCTCACCTT 
GTTGCTCTAG CAGAGAGAGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269162.1
CDS	303..806
Translation	MTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD

Target ORF information:

RefSeq Version	NM_001282233.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 20S subunit alpha 6 (PSMA6), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282233.1

ORF Insert Sequence:

ATGACCGGAA TGACAGCTGA CAGCAGATCC CAGGTACAGA GGGCACGCTA TGAGGCAGCT 
AACTGGAAAT ACAAGTATGG CTATGAGATT CCTGTGGACA TGCTGTGTAA AAGAATTGCC 
GATATTTCTC AGGTCTACAC ACAGAATGCT GAAATGAGGC CTCTTGGTTG TTGTATGATT 
TTAATTGGTA TAGATGAAGA GCAAGGCCCT CAGGTATATA AGTGTGATCC TGCAGGTTAC 
TACTGTGGGT TTAAAGCCAC TGCAGCGGGA GTTAAACAAA CTGAGTCAAC CAGCTTCCTT 
GAAAAAAAAG TGAAGAAGAA ATTTGATTGG ACATTTGAAC AGACAGTGGA AACTGCAATT 
ACATGCCTGT CTACTGTTCT ATCAATTGAT TTCAAACCTT CAGAAATAGA AGTTGGAGTA 
GTGACAGTTG AAAATCCTAA ATTCAGGATT CTTACAGAAG CAGAGATTGA TGCTCACCTT 
GTTGCTCTAG CAGAGAGAGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMA6 ( NM_002791.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002782.1 Homo sapiens proteasome 20S subunit alpha 6 (PSMA6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21602
Clone ID Related Accession (Same CDS sequence)	NM_002791.3 , NM_002791.2
Accession Version	NM_002791.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 741bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571932800000
Organism	Homo sapiens(human)
Product	proteasome subunit alpha type-6 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG701535.1, BC002979.1, BQ009843.1 and AL133163.3. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_002791.2. Transcript Variant: This variant (1) encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.272449.1, SRR1803611.73024.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000261479.9/ ENSP00000261479.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCCGTG GTTCCAGCGC CGGTTTTGAC CGCCACATTA CCATTTTTTC ACCCGAGGGT 
CGGCTCTACC AAGTAGAATA TGCTTTTAAG GCTATTAACC AGGGTGGCCT TACATCAGTA 
GCTGTCAGAG GGAAAGACTG TGCAGTAATT GTCACACAGA AGAAAGTACC TGACAAATTA 
TTGGATTCCA GCACAGTGAC TCACTTATTC AAGATAACTG AAAACATTGG TTGTGTGATG 
ACCGGAATGA CAGCTGACAG CAGATCCCAG GTACAGAGGG CACGCTATGA GGCAGCTAAC 
TGGAAATACA AGTATGGCTA TGAGATTCCT GTGGACATGC TGTGTAAAAG AATTGCCGAT 
ATTTCTCAGG TCTACACACA GAATGCTGAA ATGAGGCCTC TTGGTTGTTG TATGATTTTA 
ATTGGTATAG ATGAAGAGCA AGGCCCTCAG GTATATAAGT GTGATCCTGC AGGTTACTAC 
TGTGGGTTTA AAGCCACTGC AGCGGGAGTT AAACAAACTG AGTCAACCAG CTTCCTTGAA 
AAAAAAGTGA AGAAGAAATT TGATTGGACA TTTGAACAGA CAGTGGAAAC TGCAATTACA 
TGCCTGTCTA CTGTTCTATC AATTGATTTC AAACCTTCAG AAATAGAAGT TGGAGTAGTG 
ACAGTTGAAA ATCCTAAATT CAGGATTCTT ACAGAAGCAG AGATTGATGC TCACCTTGTT 
GCTCTAGCAG AGAGAGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002782.1
CDS	96..836
Translation	MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD

Target ORF information:

RefSeq Version	NM_002791.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 20S subunit alpha 6 (PSMA6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002791.3

ORF Insert Sequence:

ATGTCCCGTG GTTCCAGCGC CGGTTTTGAC CGCCACATTA CCATTTTTTC ACCCGAGGGT 
CGGCTCTACC AAGTAGAATA TGCTTTTAAG GCTATTAACC AGGGTGGCCT TACATCAGTA 
GCTGTCAGAG GGAAAGACTG TGCAGTAATT GTCACACAGA AGAAAGTACC TGACAAATTA 
TTGGATTCCA GCACAGTGAC TCACTTATTC AAGATAACTG AAAACATTGG TTGTGTGATG 
ACCGGAATGA CAGCTGACAG CAGATCCCAG GTACAGAGGG CACGCTATGA GGCAGCTAAC 
TGGAAATACA AGTATGGCTA TGAGATTCCT GTGGACATGC TGTGTAAAAG AATTGCCGAT 
ATTTCTCAGG TCTACACACA GAATGCTGAA ATGAGGCCTC TTGGTTGTTG TATGATTTTA 
ATTGGTATAG ATGAAGAGCA AGGCCCTCAG GTATATAAGT GTGATCCTGC AGGTTACTAC 
TGTGGGTTTA AAGCCACTGC AGCGGGAGTT AAACAAACTG AGTCAACCAG CTTCCTTGAA 
AAAAAAGTGA AGAAGAAATT TGATTGGACA TTTGAACAGA CAGTGGAAAC TGCAATTACA 
TGCCTGTCTA CTGTTCTATC AATTGATTTC AAACCTTCAG AAATAGAAGT TGGAGTAGTG 
ACAGTTGAAA ATCCTAAATT CAGGATTCTT ACAGAAGCAG AGATTGATGC TCACCTTGTT 
GCTCTAGCAG AGAGAGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMA6 ( NM_002791.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002782.1 Homo sapiens proteasome subunit alpha 6 (PSMA6), transcript variant 1, mRNA.

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CloneID	OHu21602
Clone ID Related Accession (Same CDS sequence)	NM_002791.3 , NM_002791.2
Accession Version	NM_002791.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 741bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550851200000
Organism	Homo sapiens(human)
Product	proteasome subunit alpha type-6 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU657545.1, BG701535.1, BC002979.1 and BQ009843.1. This sequence is a reference standard in the RefSeqGene project. On Aug 24, 2013 this sequence version replaced NM_002791.1. Transcript Variant: This variant (1) encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.560684.1, SRR1163655.33115.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCGTG GTTCCAGCGC CGGTTTTGAC CGCCACATTA CCATTTTTTC ACCCGAGGGT 
CGGCTCTACC AAGTAGAATA TGCTTTTAAG GCTATTAACC AGGGTGGCCT TACATCAGTA 
GCTGTCAGAG GGAAAGACTG TGCAGTAATT GTCACACAGA AGAAAGTACC TGACAAATTA 
TTGGATTCCA GCACAGTGAC TCACTTATTC AAGATAACTG AAAACATTGG TTGTGTGATG 
ACCGGAATGA CAGCTGACAG CAGATCCCAG GTACAGAGGG CACGCTATGA GGCAGCTAAC 
TGGAAATACA AGTATGGCTA TGAGATTCCT GTGGACATGC TGTGTAAAAG AATTGCCGAT 
ATTTCTCAGG TCTACACACA GAATGCTGAA ATGAGGCCTC TTGGTTGTTG TATGATTTTA 
ATTGGTATAG ATGAAGAGCA AGGCCCTCAG GTATATAAGT GTGATCCTGC AGGTTACTAC 
TGTGGGTTTA AAGCCACTGC AGCGGGAGTT AAACAAACTG AGTCAACCAG CTTCCTTGAA 
AAAAAAGTGA AGAAGAAATT TGATTGGACA TTTGAACAGA CAGTGGAAAC TGCAATTACA 
TGCCTGTCTA CTGTTCTATC AATTGATTTC AAACCTTCAG AAATAGAAGT TGGAGTAGTG 
ACAGTTGAAA ATCCTAAATT CAGGATTCTT ACAGAAGCAG AGATTGATGC TCACCTTGTT 
GCTCTAGCAG AGAGAGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002782.1
CDS	161..901
Translation	MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD

Target ORF information:

RefSeq Version	NM_002791.2
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome subunit alpha 6 (PSMA6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002791.2

ORF Insert Sequence:

ATGTCCCGTG GTTCCAGCGC CGGTTTTGAC CGCCACATTA CCATTTTTTC ACCCGAGGGT 
CGGCTCTACC AAGTAGAATA TGCTTTTAAG GCTATTAACC AGGGTGGCCT TACATCAGTA 
GCTGTCAGAG GGAAAGACTG TGCAGTAATT GTCACACAGA AGAAAGTACC TGACAAATTA 
TTGGATTCCA GCACAGTGAC TCACTTATTC AAGATAACTG AAAACATTGG TTGTGTGATG 
ACCGGAATGA CAGCTGACAG CAGATCCCAG GTACAGAGGG CACGCTATGA GGCAGCTAAC 
TGGAAATACA AGTATGGCTA TGAGATTCCT GTGGACATGC TGTGTAAAAG AATTGCCGAT 
ATTTCTCAGG TCTACACACA GAATGCTGAA ATGAGGCCTC TTGGTTGTTG TATGATTTTA 
ATTGGTATAG ATGAAGAGCA AGGCCCTCAG GTATATAAGT GTGATCCTGC AGGTTACTAC 
TGTGGGTTTA AAGCCACTGC AGCGGGAGTT AAACAAACTG AGTCAACCAG CTTCCTTGAA 
AAAAAAGTGA AGAAGAAATT TGATTGGACA TTTGAACAGA CAGTGGAAAC TGCAATTACA 
TGCCTGTCTA CTGTTCTATC AATTGATTTC AAACCTTCAG AAATAGAAGT TGGAGTAGTG 
ACAGTTGAAA ATCCTAAATT CAGGATTCTT ACAGAAGCAG AGATTGATGC TCACCTTGTT 
GCTCTAGCAG AGAGAGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMA6 ( XM_017021468.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016876957.1 Homo sapiens proteasome 20S subunit alpha 6 (PSMA6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu04888
Clone ID Related Accession (Same CDS sequence)	XM_017021468.1 , NM_001282232.1 , NM_001282233.1
Accession Version	XM_017021468.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	proteasome subunit alpha type-6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCGGAA TGACAGCTGA CAGCAGATCC CAGGTACAGA GGGCACGCTA TGAGGCAGCT 
AACTGGAAAT ACAAGTATGG CTATGAGATT CCTGTGGACA TGCTGTGTAA AAGAATTGCC 
GATATTTCTC AGGTCTACAC ACAGAATGCT GAAATGAGGC CTCTTGGTTG TTGTATGATT 
TTAATTGGTA TAGATGAAGA GCAAGGCCCT CAGGTATATA AGTGTGATCC TGCAGGTTAC 
TACTGTGGGT TTAAAGCCAC TGCAGCGGGA GTTAAACAAA CTGAGTCAAC CAGCTTCCTT 
GAAAAAAAAG TGAAGAAGAA ATTTGATTGG ACATTTGAAC AGACAGTGGA AACTGCAATT 
ACATGCCTGT CTACTGTTCT ATCAATTGAT TTCAAACCTT CAGAAATAGA AGTTGGAGTA 
GTGACAGTTG AAAATCCTAA ATTCAGGATT CTTACAGAAG CAGAGATTGA TGCTCACCTT 
GTTGCTCTAG CAGAGAGAGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016876957.1
CDS	1734..2237
Translation	MTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD

Target ORF information:

RefSeq Version	XM_017021468.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 20S subunit alpha 6 (PSMA6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017021468.1

ORF Insert Sequence:

ATGACCGGAA TGACAGCTGA CAGCAGATCC CAGGTACAGA GGGCACGCTA TGAGGCAGCT 
AACTGGAAAT ACAAGTATGG CTATGAGATT CCTGTGGACA TGCTGTGTAA AAGAATTGCC 
GATATTTCTC AGGTCTACAC ACAGAATGCT GAAATGAGGC CTCTTGGTTG TTGTATGATT 
TTAATTGGTA TAGATGAAGA GCAAGGCCCT CAGGTATATA AGTGTGATCC TGCAGGTTAC 
TACTGTGGGT TTAAAGCCAC TGCAGCGGGA GTTAAACAAA CTGAGTCAAC CAGCTTCCTT 
GAAAAAAAAG TGAAGAAGAA ATTTGATTGG ACATTTGAAC AGACAGTGGA AACTGCAATT 
ACATGCCTGT CTACTGTTCT ATCAATTGAT TTCAAACCTT CAGAAATAGA AGTTGGAGTA 
GTGACAGTTG AAAATCCTAA ATTCAGGATT CTTACAGAAG CAGAGATTGA TGCTCACCTT 
GTTGCTCTAG CAGAGAGAGA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells.
BMC cancer19(1)253(2019 Mar)
Bakke J,Wright WC,Zamora AE,Oladimeji P,Crawford JC,Brewer CT,Autry RJ,Evans WE,Thomas PG,Chen T

Proteasome subunit-α type-6 protein is post-transcriptionally repressed by the microRNA-4490 in diabetic nephropathy.
Bioscience reports38(5)(2018 10)
Feng Y,Jin MY,Liu DW,Wei L

Identification of proteasomal catalytic subunit PSMA6 as a therapeutic target for lung cancer.
Cancer science108(4)732-743(2017 Apr)
Kakumu T,Sato M,Goto D,Kato T,Yogo N,Hase T,Morise M,Fukui T,Yokoi K,Sekido Y,Girard L,Minna JD,Byers LA,Heymach JV,Coombes KR,Kondo M,Hasegawa Y

Association between functional variant of inflammatory system gene (PSMA6) and end-stage kidney disease.
International urology and nephrology48(12)2083-2087(2016 Dec)
Buraczynska M,Stec A,Filipczak A,Ksiazek A

Hepatic expression of proteasome subunit alpha type-6 is upregulated during viral hepatitis and putatively regulates the expression of ISG15 ubiquitin-like modifier, a proviral host gene in hepatitis C virus infection.
Journal of viral hepatitis23(5)375-86(2016 May)
Broering R,Trippler M,Werner M,Real CI,Megger DA,Bracht T,Schweinsberg V,Sitek B,Eisenacher M,Meyer HE,Baba HA,Weber F,Hoffmann AC,Gerken G,Schlaak JF

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PSMA6 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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