Rnf146 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rnf146
Entrez Gene ID	68031
Full Name	ring finger protein 146
Synonyms	2610509H23Rik,Iduna
General protein information	Preferred Names ring finger protein 146 Names E3 ubiquitin-protein ligase RNF146 RING-type E3 ubiquitin transferase RNF146
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 A4

mRNA and Protein(s)

mRNA	Protein	Name
NM_026518.4	NP_080794.2	E3 ubiquitin-protein ligase RNF146
NM_001110198.1	NP_001103668.1	E3 ubiquitin-protein ligase RNF146
NM_001110196.1	NP_001103666.1	E3 ubiquitin-protein ligase RNF146
NM_001110197.1	NP_001103667.1	E3 ubiquitin-protein ligase RNF146
NM_001284279.1	NP_001271208.1	E3 ubiquitin-protein ligase RNF146

Pathways from BioSystems

Homologies

Homo sapiens (human)	RNF146	NP_001229780.1
Pan troglodytes (chimpanzee)	RNF146	XP_001166481.2
Macaca mulatta (Rhesus monkey)	RNF146	XP_001106392.2
Gallus gallus (chicken)	RNF146	XP_423089.3
Danio rerio (zebrafish)	rnf146	NP_956148.1
Xenopus tropicalis (tropical clawed frog)	rnf146	NP_001008060.1
Canis lupus familiaris (dog)	RNF146	XP_005615679.1
Bos taurus (cattle)	RNF146B	NP_001070448.1
Mus musculus (house mouse)	Rnf146	NP_001103666.1
Rattus norvegicus (Norway rat)	Rnf146	NP_001012060.2

Gene Ontology
Bibliography

Related articles in PubMed

Rhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress.
Kim H, Park J, Leem H, Cho M, Yoon JH, Maeng HJ, Lee Y
International journal of molecular sciences20(7)(2019 Apr)

Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism.
Matsumoto Y, La Rose J, Lim M, Adissu HA, Law N, Mao X, Cong F, Mera P, Karsenty G, Goltzman D, Changoor A, Zhang L, Stajkowski M, Grynpas MD, Bergmann C, Rottapel R
The Journal of clinical investigation127(7)2612-2625(2017 Jun)

RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146.
Matsumoto Y, Larose J, Kent OA, Lim M, Changoor A, Zhang L, Storozhuk Y, Mao X, Grynpas MD, Cong F, Rottapel R
The Journal of clinical investigation127(4)1303-1315(2017 Apr)

The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.
Campbell CI, Samavarchi-Tehrani P, Barrios-Rodiles M, Datti A, Gingras AC, Wrana JL
Journal of cell science129(18)3396-411(2016 09)

Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
DaRosa PA, Wang Z, Jiang X, Pruneda JN, Cong F, Klevit RE, Xu W
Nature517(7533)223-6(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Rnf146 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rnf146 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu02488	NM_026518.4 Latest version!	Mus musculus ring finger protein 146 (Rnf146), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$188.30 $269.00
OMu02488	NM_001110196.1 Latest version!	Mus musculus ring finger protein 146 (Rnf146), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$188.30 $269.00
OMu02488	NM_001284279.1 Latest version!	Mus musculus ring finger protein 146 (Rnf146), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$188.30 $269.00
OMu02488	NM_001110197.1 Latest version!	Mus musculus ring finger protein 146 (Rnf146), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$188.30 $269.00
OMu02488	NM_001110198.1 Latest version!	Mus musculus ring finger protein 146 (Rnf146), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rnf146 ( NM_026518.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080794.2 Mus musculus ring finger protein 146 (Rnf146), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OMu02488
Clone ID Related Accession (Same CDS sequence)	NM_026518.4 , NM_001110198.1 , NM_001110196.1 , NM_001110197.1 , NM_001284279.1
Accession Version	NM_026518.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565020800000
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase RNF146
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC050795.1, BQ713250.1, AK035665.1 and BF461810.1. On Oct 30, 2007 this sequence version replaced NM_026518.3. Transcript Variant: This variant (4) has an alternate splice site and also lacks an exon in the 5' UTR, compared to variant 1. All variants encode the same protein. ##Evidence-Data-START## Transcript exon combination :: BC050795.1, AK169237.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGATGG CCGGCTGTGG TGAAATTGAT CACTCAATAA ATATGCTTCC TACAAATAAG 
AAGGCAAATG AGTCCTGTTC CAATACTGCA CCTTCTCTGA CAGTTCCTGA ATGTGCCATT 
TGTCTACAAA CATGTGTTCA CCCTGTCAGT CTGCCCTGTA AGCATGTTTT CTGTTATCTG 
TGTGTAAAGG GTGCTTCATG GCTTGGGAAG CGATGTGCTC TTTGTCGACA AGAGATTCCT 
GAGGATTTTC TTGACAAGCC AACCTTGTTG TCACCAGAAG AACTTAAGGC TGCAAGCAGA 
GGAAATGGTG AATATGCGTG GTATTATGAA GGAAGGAATG GGTGGTGGCA GTATGATGAG 
CGCACTAGTC GGGAGCTAGA AGATGCTTTT TCCAAAGGTA AAAAGAACAC GGAAATGTTA 
ATTGCTGGAT TTCTGTATGT TGCTGATCTT GAAAACATGG TTCAATATAG GAGAAATGAA 
CATGGACGTC GCAGGAAGAT TAAGCGAGAT ATAATAGATA TACCAAAGAA GGGAGTAGCT 
GGACTTAGGC TGGACTGTGA CACCAATACT GTAAATCTAG CAAGAGAGAG TTCTGCTGAT 
GGTGCGGACA GTGGATCAGC ACAGACTGGA GCTTCTGTTC AGCTTGCAGT GCCATCTTCT 
ACAAGGCCCC TGACATCAGT TGATGGTCAG TTAACCAGCC CTGTAACACC ATCCCCTGAT 
GCAGGCATTT CTTTGGAAGA CTCTTTTGCT CATTTACAAC TCAGTGGAGA CAGCATAGCT 
GAACGGAGTC ACAGAGGTGA AGGAGAAGAA GATCATGAAT CGCCATCTTC TGGCAGAGTA 
CCAGATACCT CCGTTGAAGA AACAGAATCA GATGCCAGTA GTGATAGTGA GGATGCCCCT 
GTGGTAGTTG CACAGCACTC TTTGACCCAA CAGAGACCTT TGGTTCCAAA TGGAAACCAG 
ACAGTAGCCG ACCAGTCAGA CCGATCAGGA ACTGACCGAT CAGTTGCAGG GGGTGGGACC 
ATGAGTGTCA ATGTCAGATC CAGAAGGCCT GATGGGCAGT GCACAGTGAC AGAGGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080794.2
CDS	611..1690
Translation	MEMAGCGEIDHSINMLPTNKKANESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDTNTVNLARESSADGADSGSAQTGASVQLAVPSSTRPLTSVDGQLTSPVTPSPDAGISLEDSFAHLQLSGDSIAERSHRGEGEEDHESPSSGRVPDTSVEETESDASSDSEDAPVVVAQHSLTQQRPLVPNGNQTVADQSDRSGTDRSVAGGGTMSVNVRSRRPDGQCTVTEV

Target ORF information:

RefSeq Version	NM_026518.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus ring finger protein 146 (Rnf146), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026518.4

ORF Insert Sequence:

ATGGAGATGG CCGGCTGTGG TGAAATTGAT CACTCAATAA ATATGCTTCC TACAAATAAG 
AAGGCAAATG AGTCCTGTTC CAATACTGCA CCTTCTCTGA CAGTTCCTGA ATGTGCCATT 
TGTCTACAAA CATGTGTTCA CCCTGTCAGT CTGCCCTGTA AGCATGTTTT CTGTTATCTG 
TGTGTAAAGG GTGCTTCATG GCTTGGGAAG CGATGTGCTC TTTGTCGACA AGAGATTCCT 
GAGGATTTTC TTGACAAGCC AACCTTGTTG TCACCAGAAG AACTTAAGGC TGCAAGCAGA 
GGAAATGGTG AATATGCGTG GTATTATGAA GGAAGGAATG GGTGGTGGCA GTATGATGAG 
CGCACTAGTC GGGAGCTAGA AGATGCTTTT TCCAAAGGTA AAAAGAACAC GGAAATGTTA 
ATTGCTGGAT TTCTGTATGT TGCTGATCTT GAAAACATGG TTCAATATAG GAGAAATGAA 
CATGGACGTC GCAGGAAGAT TAAGCGAGAT ATAATAGATA TACCAAAGAA GGGAGTAGCT 
GGACTTAGGC TGGACTGTGA CACCAATACT GTAAATCTAG CAAGAGAGAG TTCTGCTGAT 
GGTGCGGACA GTGGATCAGC ACAGACTGGA GCTTCTGTTC AGCTTGCAGT GCCATCTTCT 
ACAAGGCCCC TGACATCAGT TGATGGTCAG TTAACCAGCC CTGTAACACC ATCCCCTGAT 
GCAGGCATTT CTTTGGAAGA CTCTTTTGCT CATTTACAAC TCAGTGGAGA CAGCATAGCT 
GAACGGAGTC ACAGAGGTGA AGGAGAAGAA GATCATGAAT CGCCATCTTC TGGCAGAGTA 
CCAGATACCT CCGTTGAAGA AACAGAATCA GATGCCAGTA GTGATAGTGA GGATGCCCCT 
GTGGTAGTTG CACAGCACTC TTTGACCCAA CAGAGACCTT TGGTTCCAAA TGGAAACCAG 
ACAGTAGCCG ACCAGTCAGA CCGATCAGGA ACTGACCGAT CAGTTGCAGG GGGTGGGACC 
ATGAGTGTCA ATGTCAGATC CAGAAGGCCT GATGGGCAGT GCACAGTGAC AGAGGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rnf146 ( NM_001110198.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001103668.1 Mus musculus ring finger protein 146 (Rnf146), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu02488
Clone ID Related Accession (Same CDS sequence)	NM_026518.4 , NM_001110198.1 , NM_001110196.1 , NM_001110197.1 , NM_001284279.1
Accession Version	NM_001110198.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565020800000
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase RNF146
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC050795.1, BU562186.1, BQ713250.1, AK035665.1 and BF461810.1. Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, compared to variant 1. All variants encode the same protein. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.193618.1, SRR1660815.72084.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGATGG CCGGCTGTGG TGAAATTGAT CACTCAATAA ATATGCTTCC TACAAATAAG 
AAGGCAAATG AGTCCTGTTC CAATACTGCA CCTTCTCTGA CAGTTCCTGA ATGTGCCATT 
TGTCTACAAA CATGTGTTCA CCCTGTCAGT CTGCCCTGTA AGCATGTTTT CTGTTATCTG 
TGTGTAAAGG GTGCTTCATG GCTTGGGAAG CGATGTGCTC TTTGTCGACA AGAGATTCCT 
GAGGATTTTC TTGACAAGCC AACCTTGTTG TCACCAGAAG AACTTAAGGC TGCAAGCAGA 
GGAAATGGTG AATATGCGTG GTATTATGAA GGAAGGAATG GGTGGTGGCA GTATGATGAG 
CGCACTAGTC GGGAGCTAGA AGATGCTTTT TCCAAAGGTA AAAAGAACAC GGAAATGTTA 
ATTGCTGGAT TTCTGTATGT TGCTGATCTT GAAAACATGG TTCAATATAG GAGAAATGAA 
CATGGACGTC GCAGGAAGAT TAAGCGAGAT ATAATAGATA TACCAAAGAA GGGAGTAGCT 
GGACTTAGGC TGGACTGTGA CACCAATACT GTAAATCTAG CAAGAGAGAG TTCTGCTGAT 
GGTGCGGACA GTGGATCAGC ACAGACTGGA GCTTCTGTTC AGCTTGCAGT GCCATCTTCT 
ACAAGGCCCC TGACATCAGT TGATGGTCAG TTAACCAGCC CTGTAACACC ATCCCCTGAT 
GCAGGCATTT CTTTGGAAGA CTCTTTTGCT CATTTACAAC TCAGTGGAGA CAGCATAGCT 
GAACGGAGTC ACAGAGGTGA AGGAGAAGAA GATCATGAAT CGCCATCTTC TGGCAGAGTA 
CCAGATACCT CCGTTGAAGA AACAGAATCA GATGCCAGTA GTGATAGTGA GGATGCCCCT 
GTGGTAGTTG CACAGCACTC TTTGACCCAA CAGAGACCTT TGGTTCCAAA TGGAAACCAG 
ACAGTAGCCG ACCAGTCAGA CCGATCAGGA ACTGACCGAT CAGTTGCAGG GGGTGGGACC 
ATGAGTGTCA ATGTCAGATC CAGAAGGCCT GATGGGCAGT GCACAGTGAC AGAGGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103668.1
CDS	672..1751
Translation	MEMAGCGEIDHSINMLPTNKKANESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDTNTVNLARESSADGADSGSAQTGASVQLAVPSSTRPLTSVDGQLTSPVTPSPDAGISLEDSFAHLQLSGDSIAERSHRGEGEEDHESPSSGRVPDTSVEETESDASSDSEDAPVVVAQHSLTQQRPLVPNGNQTVADQSDRSGTDRSVAGGGTMSVNVRSRRPDGQCTVTEV

Target ORF information:

RefSeq Version	NM_001110198.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ring finger protein 146 (Rnf146), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001110198.1

ORF Insert Sequence:

ATGGAGATGG CCGGCTGTGG TGAAATTGAT CACTCAATAA ATATGCTTCC TACAAATAAG 
AAGGCAAATG AGTCCTGTTC CAATACTGCA CCTTCTCTGA CAGTTCCTGA ATGTGCCATT 
TGTCTACAAA CATGTGTTCA CCCTGTCAGT CTGCCCTGTA AGCATGTTTT CTGTTATCTG 
TGTGTAAAGG GTGCTTCATG GCTTGGGAAG CGATGTGCTC TTTGTCGACA AGAGATTCCT 
GAGGATTTTC TTGACAAGCC AACCTTGTTG TCACCAGAAG AACTTAAGGC TGCAAGCAGA 
GGAAATGGTG AATATGCGTG GTATTATGAA GGAAGGAATG GGTGGTGGCA GTATGATGAG 
CGCACTAGTC GGGAGCTAGA AGATGCTTTT TCCAAAGGTA AAAAGAACAC GGAAATGTTA 
ATTGCTGGAT TTCTGTATGT TGCTGATCTT GAAAACATGG TTCAATATAG GAGAAATGAA 
CATGGACGTC GCAGGAAGAT TAAGCGAGAT ATAATAGATA TACCAAAGAA GGGAGTAGCT 
GGACTTAGGC TGGACTGTGA CACCAATACT GTAAATCTAG CAAGAGAGAG TTCTGCTGAT 
GGTGCGGACA GTGGATCAGC ACAGACTGGA GCTTCTGTTC AGCTTGCAGT GCCATCTTCT 
ACAAGGCCCC TGACATCAGT TGATGGTCAG TTAACCAGCC CTGTAACACC ATCCCCTGAT 
GCAGGCATTT CTTTGGAAGA CTCTTTTGCT CATTTACAAC TCAGTGGAGA CAGCATAGCT 
GAACGGAGTC ACAGAGGTGA AGGAGAAGAA GATCATGAAT CGCCATCTTC TGGCAGAGTA 
CCAGATACCT CCGTTGAAGA AACAGAATCA GATGCCAGTA GTGATAGTGA GGATGCCCCT 
GTGGTAGTTG CACAGCACTC TTTGACCCAA CAGAGACCTT TGGTTCCAAA TGGAAACCAG 
ACAGTAGCCG ACCAGTCAGA CCGATCAGGA ACTGACCGAT CAGTTGCAGG GGGTGGGACC 
ATGAGTGTCA ATGTCAGATC CAGAAGGCCT GATGGGCAGT GCACAGTGAC AGAGGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rnf146 ( NM_001110196.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001103666.1 Mus musculus ring finger protein 146 (Rnf146), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu02488
Clone ID Related Accession (Same CDS sequence)	NM_026518.4 , NM_001110198.1 , NM_001110196.1 , NM_001110197.1 , NM_001284279.1
Accession Version	NM_001110196.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565020800000
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase RNF146
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC050795.1, AK012080.1, BQ713250.1, AK035665.1 and BF461810.1. Transcript Variant: This variant (3) lacks an internal exon in the 5' UTR, compared to variant 1. All variants encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AK012080.1, SRR1660813.80139.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGATGG CCGGCTGTGG TGAAATTGAT CACTCAATAA ATATGCTTCC TACAAATAAG 
AAGGCAAATG AGTCCTGTTC CAATACTGCA CCTTCTCTGA CAGTTCCTGA ATGTGCCATT 
TGTCTACAAA CATGTGTTCA CCCTGTCAGT CTGCCCTGTA AGCATGTTTT CTGTTATCTG 
TGTGTAAAGG GTGCTTCATG GCTTGGGAAG CGATGTGCTC TTTGTCGACA AGAGATTCCT 
GAGGATTTTC TTGACAAGCC AACCTTGTTG TCACCAGAAG AACTTAAGGC TGCAAGCAGA 
GGAAATGGTG AATATGCGTG GTATTATGAA GGAAGGAATG GGTGGTGGCA GTATGATGAG 
CGCACTAGTC GGGAGCTAGA AGATGCTTTT TCCAAAGGTA AAAAGAACAC GGAAATGTTA 
ATTGCTGGAT TTCTGTATGT TGCTGATCTT GAAAACATGG TTCAATATAG GAGAAATGAA 
CATGGACGTC GCAGGAAGAT TAAGCGAGAT ATAATAGATA TACCAAAGAA GGGAGTAGCT 
GGACTTAGGC TGGACTGTGA CACCAATACT GTAAATCTAG CAAGAGAGAG TTCTGCTGAT 
GGTGCGGACA GTGGATCAGC ACAGACTGGA GCTTCTGTTC AGCTTGCAGT GCCATCTTCT 
ACAAGGCCCC TGACATCAGT TGATGGTCAG TTAACCAGCC CTGTAACACC ATCCCCTGAT 
GCAGGCATTT CTTTGGAAGA CTCTTTTGCT CATTTACAAC TCAGTGGAGA CAGCATAGCT 
GAACGGAGTC ACAGAGGTGA AGGAGAAGAA GATCATGAAT CGCCATCTTC TGGCAGAGTA 
CCAGATACCT CCGTTGAAGA AACAGAATCA GATGCCAGTA GTGATAGTGA GGATGCCCCT 
GTGGTAGTTG CACAGCACTC TTTGACCCAA CAGAGACCTT TGGTTCCAAA TGGAAACCAG 
ACAGTAGCCG ACCAGTCAGA CCGATCAGGA ACTGACCGAT CAGTTGCAGG GGGTGGGACC 
ATGAGTGTCA ATGTCAGATC CAGAAGGCCT GATGGGCAGT GCACAGTGAC AGAGGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103666.1
CDS	631..1710
Translation	MEMAGCGEIDHSINMLPTNKKANESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDTNTVNLARESSADGADSGSAQTGASVQLAVPSSTRPLTSVDGQLTSPVTPSPDAGISLEDSFAHLQLSGDSIAERSHRGEGEEDHESPSSGRVPDTSVEETESDASSDSEDAPVVVAQHSLTQQRPLVPNGNQTVADQSDRSGTDRSVAGGGTMSVNVRSRRPDGQCTVTEV

Target ORF information:

RefSeq Version	NM_001110196.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ring finger protein 146 (Rnf146), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001110196.1

ORF Insert Sequence:

ATGGAGATGG CCGGCTGTGG TGAAATTGAT CACTCAATAA ATATGCTTCC TACAAATAAG 
AAGGCAAATG AGTCCTGTTC CAATACTGCA CCTTCTCTGA CAGTTCCTGA ATGTGCCATT 
TGTCTACAAA CATGTGTTCA CCCTGTCAGT CTGCCCTGTA AGCATGTTTT CTGTTATCTG 
TGTGTAAAGG GTGCTTCATG GCTTGGGAAG CGATGTGCTC TTTGTCGACA AGAGATTCCT 
GAGGATTTTC TTGACAAGCC AACCTTGTTG TCACCAGAAG AACTTAAGGC TGCAAGCAGA 
GGAAATGGTG AATATGCGTG GTATTATGAA GGAAGGAATG GGTGGTGGCA GTATGATGAG 
CGCACTAGTC GGGAGCTAGA AGATGCTTTT TCCAAAGGTA AAAAGAACAC GGAAATGTTA 
ATTGCTGGAT TTCTGTATGT TGCTGATCTT GAAAACATGG TTCAATATAG GAGAAATGAA 
CATGGACGTC GCAGGAAGAT TAAGCGAGAT ATAATAGATA TACCAAAGAA GGGAGTAGCT 
GGACTTAGGC TGGACTGTGA CACCAATACT GTAAATCTAG CAAGAGAGAG TTCTGCTGAT 
GGTGCGGACA GTGGATCAGC ACAGACTGGA GCTTCTGTTC AGCTTGCAGT GCCATCTTCT 
ACAAGGCCCC TGACATCAGT TGATGGTCAG TTAACCAGCC CTGTAACACC ATCCCCTGAT 
GCAGGCATTT CTTTGGAAGA CTCTTTTGCT CATTTACAAC TCAGTGGAGA CAGCATAGCT 
GAACGGAGTC ACAGAGGTGA AGGAGAAGAA GATCATGAAT CGCCATCTTC TGGCAGAGTA 
CCAGATACCT CCGTTGAAGA AACAGAATCA GATGCCAGTA GTGATAGTGA GGATGCCCCT 
GTGGTAGTTG CACAGCACTC TTTGACCCAA CAGAGACCTT TGGTTCCAAA TGGAAACCAG 
ACAGTAGCCG ACCAGTCAGA CCGATCAGGA ACTGACCGAT CAGTTGCAGG GGGTGGGACC 
ATGAGTGTCA ATGTCAGATC CAGAAGGCCT GATGGGCAGT GCACAGTGAC AGAGGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rnf146 ( NM_001110197.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001103667.1 Mus musculus ring finger protein 146 (Rnf146), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu02488
Clone ID Related Accession (Same CDS sequence)	NM_026518.4 , NM_001110198.1 , NM_001110196.1 , NM_001110197.1 , NM_001284279.1
Accession Version	NM_001110197.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564934400000
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase RNF146
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC050795.1, BY787516.1, BQ713250.1, AK035665.1 and BF461810.1. Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein. ##Evidence-Data-START## Transcript exon combination :: SRR1660821.62813.1, SRR1660811.2108.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164142 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGATGG CCGGCTGTGG TGAAATTGAT CACTCAATAA ATATGCTTCC TACAAATAAG 
AAGGCAAATG AGTCCTGTTC CAATACTGCA CCTTCTCTGA CAGTTCCTGA ATGTGCCATT 
TGTCTACAAA CATGTGTTCA CCCTGTCAGT CTGCCCTGTA AGCATGTTTT CTGTTATCTG 
TGTGTAAAGG GTGCTTCATG GCTTGGGAAG CGATGTGCTC TTTGTCGACA AGAGATTCCT 
GAGGATTTTC TTGACAAGCC AACCTTGTTG TCACCAGAAG AACTTAAGGC TGCAAGCAGA 
GGAAATGGTG AATATGCGTG GTATTATGAA GGAAGGAATG GGTGGTGGCA GTATGATGAG 
CGCACTAGTC GGGAGCTAGA AGATGCTTTT TCCAAAGGTA AAAAGAACAC GGAAATGTTA 
ATTGCTGGAT TTCTGTATGT TGCTGATCTT GAAAACATGG TTCAATATAG GAGAAATGAA 
CATGGACGTC GCAGGAAGAT TAAGCGAGAT ATAATAGATA TACCAAAGAA GGGAGTAGCT 
GGACTTAGGC TGGACTGTGA CACCAATACT GTAAATCTAG CAAGAGAGAG TTCTGCTGAT 
GGTGCGGACA GTGGATCAGC ACAGACTGGA GCTTCTGTTC AGCTTGCAGT GCCATCTTCT 
ACAAGGCCCC TGACATCAGT TGATGGTCAG TTAACCAGCC CTGTAACACC ATCCCCTGAT 
GCAGGCATTT CTTTGGAAGA CTCTTTTGCT CATTTACAAC TCAGTGGAGA CAGCATAGCT 
GAACGGAGTC ACAGAGGTGA AGGAGAAGAA GATCATGAAT CGCCATCTTC TGGCAGAGTA 
CCAGATACCT CCGTTGAAGA AACAGAATCA GATGCCAGTA GTGATAGTGA GGATGCCCCT 
GTGGTAGTTG CACAGCACTC TTTGACCCAA CAGAGACCTT TGGTTCCAAA TGGAAACCAG 
ACAGTAGCCG ACCAGTCAGA CCGATCAGGA ACTGACCGAT CAGTTGCAGG GGGTGGGACC 
ATGAGTGTCA ATGTCAGATC CAGAAGGCCT GATGGGCAGT GCACAGTGAC AGAGGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103667.1
CDS	692..1771
Translation	MEMAGCGEIDHSINMLPTNKKANESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDTNTVNLARESSADGADSGSAQTGASVQLAVPSSTRPLTSVDGQLTSPVTPSPDAGISLEDSFAHLQLSGDSIAERSHRGEGEEDHESPSSGRVPDTSVEETESDASSDSEDAPVVVAQHSLTQQRPLVPNGNQTVADQSDRSGTDRSVAGGGTMSVNVRSRRPDGQCTVTEV

Target ORF information:

RefSeq Version	NM_001110197.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ring finger protein 146 (Rnf146), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001110197.1

ORF Insert Sequence:

ATGGAGATGG CCGGCTGTGG TGAAATTGAT CACTCAATAA ATATGCTTCC TACAAATAAG 
AAGGCAAATG AGTCCTGTTC CAATACTGCA CCTTCTCTGA CAGTTCCTGA ATGTGCCATT 
TGTCTACAAA CATGTGTTCA CCCTGTCAGT CTGCCCTGTA AGCATGTTTT CTGTTATCTG 
TGTGTAAAGG GTGCTTCATG GCTTGGGAAG CGATGTGCTC TTTGTCGACA AGAGATTCCT 
GAGGATTTTC TTGACAAGCC AACCTTGTTG TCACCAGAAG AACTTAAGGC TGCAAGCAGA 
GGAAATGGTG AATATGCGTG GTATTATGAA GGAAGGAATG GGTGGTGGCA GTATGATGAG 
CGCACTAGTC GGGAGCTAGA AGATGCTTTT TCCAAAGGTA AAAAGAACAC GGAAATGTTA 
ATTGCTGGAT TTCTGTATGT TGCTGATCTT GAAAACATGG TTCAATATAG GAGAAATGAA 
CATGGACGTC GCAGGAAGAT TAAGCGAGAT ATAATAGATA TACCAAAGAA GGGAGTAGCT 
GGACTTAGGC TGGACTGTGA CACCAATACT GTAAATCTAG CAAGAGAGAG TTCTGCTGAT 
GGTGCGGACA GTGGATCAGC ACAGACTGGA GCTTCTGTTC AGCTTGCAGT GCCATCTTCT 
ACAAGGCCCC TGACATCAGT TGATGGTCAG TTAACCAGCC CTGTAACACC ATCCCCTGAT 
GCAGGCATTT CTTTGGAAGA CTCTTTTGCT CATTTACAAC TCAGTGGAGA CAGCATAGCT 
GAACGGAGTC ACAGAGGTGA AGGAGAAGAA GATCATGAAT CGCCATCTTC TGGCAGAGTA 
CCAGATACCT CCGTTGAAGA AACAGAATCA GATGCCAGTA GTGATAGTGA GGATGCCCCT 
GTGGTAGTTG CACAGCACTC TTTGACCCAA CAGAGACCTT TGGTTCCAAA TGGAAACCAG 
ACAGTAGCCG ACCAGTCAGA CCGATCAGGA ACTGACCGAT CAGTTGCAGG GGGTGGGACC 
ATGAGTGTCA ATGTCAGATC CAGAAGGCCT GATGGGCAGT GCACAGTGAC AGAGGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rnf146 ( NM_001284279.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001271208.1 Mus musculus ring finger protein 146 (Rnf146), transcript variant 5, mRNA.

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CloneID	OMu02488
Clone ID Related Accession (Same CDS sequence)	NM_026518.4 , NM_001110198.1 , NM_001110196.1 , NM_001110197.1 , NM_001284279.1
Accession Version	NM_001284279.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565020800000
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase RNF146
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK016748.1, AK012080.1, AC153912.8 and BF461810.1. Transcript Variant: This variant (5) has an alternate 5' UTR exon, compared to variant 1. All variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK016748.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END##

ATGGAGATGG CCGGCTGTGG TGAAATTGAT CACTCAATAA ATATGCTTCC TACAAATAAG 
AAGGCAAATG AGTCCTGTTC CAATACTGCA CCTTCTCTGA CAGTTCCTGA ATGTGCCATT 
TGTCTACAAA CATGTGTTCA CCCTGTCAGT CTGCCCTGTA AGCATGTTTT CTGTTATCTG 
TGTGTAAAGG GTGCTTCATG GCTTGGGAAG CGATGTGCTC TTTGTCGACA AGAGATTCCT 
GAGGATTTTC TTGACAAGCC AACCTTGTTG TCACCAGAAG AACTTAAGGC TGCAAGCAGA 
GGAAATGGTG AATATGCGTG GTATTATGAA GGAAGGAATG GGTGGTGGCA GTATGATGAG 
CGCACTAGTC GGGAGCTAGA AGATGCTTTT TCCAAAGGTA AAAAGAACAC GGAAATGTTA 
ATTGCTGGAT TTCTGTATGT TGCTGATCTT GAAAACATGG TTCAATATAG GAGAAATGAA 
CATGGACGTC GCAGGAAGAT TAAGCGAGAT ATAATAGATA TACCAAAGAA GGGAGTAGCT 
GGACTTAGGC TGGACTGTGA CACCAATACT GTAAATCTAG CAAGAGAGAG TTCTGCTGAT 
GGTGCGGACA GTGGATCAGC ACAGACTGGA GCTTCTGTTC AGCTTGCAGT GCCATCTTCT 
ACAAGGCCCC TGACATCAGT TGATGGTCAG TTAACCAGCC CTGTAACACC ATCCCCTGAT 
GCAGGCATTT CTTTGGAAGA CTCTTTTGCT CATTTACAAC TCAGTGGAGA CAGCATAGCT 
GAACGGAGTC ACAGAGGTGA AGGAGAAGAA GATCATGAAT CGCCATCTTC TGGCAGAGTA 
CCAGATACCT CCGTTGAAGA AACAGAATCA GATGCCAGTA GTGATAGTGA GGATGCCCCT 
GTGGTAGTTG CACAGCACTC TTTGACCCAA CAGAGACCTT TGGTTCCAAA TGGAAACCAG 
ACAGTAGCCG ACCAGTCAGA CCGATCAGGA ACTGACCGAT CAGTTGCAGG GGGTGGGACC 
ATGAGTGTCA ATGTCAGATC CAGAAGGCCT GATGGGCAGT GCACAGTGAC AGAGGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001271208.1
CDS	204..1283
Translation	MEMAGCGEIDHSINMLPTNKKANESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDTNTVNLARESSADGADSGSAQTGASVQLAVPSSTRPLTSVDGQLTSPVTPSPDAGISLEDSFAHLQLSGDSIAERSHRGEGEEDHESPSSGRVPDTSVEETESDASSDSEDAPVVVAQHSLTQQRPLVPNGNQTVADQSDRSGTDRSVAGGGTMSVNVRSRRPDGQCTVTEV

Target ORF information:

RefSeq Version	NM_001284279.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ring finger protein 146 (Rnf146), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001284279.1

ORF Insert Sequence:

ATGGAGATGG CCGGCTGTGG TGAAATTGAT CACTCAATAA ATATGCTTCC TACAAATAAG 
AAGGCAAATG AGTCCTGTTC CAATACTGCA CCTTCTCTGA CAGTTCCTGA ATGTGCCATT 
TGTCTACAAA CATGTGTTCA CCCTGTCAGT CTGCCCTGTA AGCATGTTTT CTGTTATCTG 
TGTGTAAAGG GTGCTTCATG GCTTGGGAAG CGATGTGCTC TTTGTCGACA AGAGATTCCT 
GAGGATTTTC TTGACAAGCC AACCTTGTTG TCACCAGAAG AACTTAAGGC TGCAAGCAGA 
GGAAATGGTG AATATGCGTG GTATTATGAA GGAAGGAATG GGTGGTGGCA GTATGATGAG 
CGCACTAGTC GGGAGCTAGA AGATGCTTTT TCCAAAGGTA AAAAGAACAC GGAAATGTTA 
ATTGCTGGAT TTCTGTATGT TGCTGATCTT GAAAACATGG TTCAATATAG GAGAAATGAA 
CATGGACGTC GCAGGAAGAT TAAGCGAGAT ATAATAGATA TACCAAAGAA GGGAGTAGCT 
GGACTTAGGC TGGACTGTGA CACCAATACT GTAAATCTAG CAAGAGAGAG TTCTGCTGAT 
GGTGCGGACA GTGGATCAGC ACAGACTGGA GCTTCTGTTC AGCTTGCAGT GCCATCTTCT 
ACAAGGCCCC TGACATCAGT TGATGGTCAG TTAACCAGCC CTGTAACACC ATCCCCTGAT 
GCAGGCATTT CTTTGGAAGA CTCTTTTGCT CATTTACAAC TCAGTGGAGA CAGCATAGCT 
GAACGGAGTC ACAGAGGTGA AGGAGAAGAA GATCATGAAT CGCCATCTTC TGGCAGAGTA 
CCAGATACCT CCGTTGAAGA AACAGAATCA GATGCCAGTA GTGATAGTGA GGATGCCCCT 
GTGGTAGTTG CACAGCACTC TTTGACCCAA CAGAGACCTT TGGTTCCAAA TGGAAACCAG 
ACAGTAGCCG ACCAGTCAGA CCGATCAGGA ACTGACCGAT CAGTTGCAGG GGGTGGGACC 
ATGAGTGTCA ATGTCAGATC CAGAAGGCCT GATGGGCAGT GCACAGTGAC AGAGGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress.
International journal of molecular sciences20(7)(2019 Apr)
Kim H,Park J,Leem H,Cho M,Yoon JH,Maeng HJ,Lee Y

Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism.
The Journal of clinical investigation127(7)2612-2625(2017 Jun)
Matsumoto Y,La Rose J,Lim M,Adissu HA,Law N,Mao X,Cong F,Mera P,Karsenty G,Goltzman D,Changoor A,Zhang L,Stajkowski M,Grynpas MD,Bergmann C,Rottapel R

RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146.
The Journal of clinical investigation127(4)1303-1315(2017 Apr)
Matsumoto Y,Larose J,Kent OA,Lim M,Changoor A,Zhang L,Storozhuk Y,Mao X,Grynpas MD,Cong F,Rottapel R

The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.
Journal of cell science129(18)3396-411(2016 09)
Campbell CI,Samavarchi-Tehrani P,Barrios-Rodiles M,Datti A,Gingras AC,Wrana JL

Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
Nature517(7533)223-6(2015 Jan)
DaRosa PA,Wang Z,Jiang X,Pruneda JN,Cong F,Klevit RE,Xu W

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Rnf146 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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