F5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	F5
Entrez Gene ID	14067
Full Name	coagulation factor V
Synonyms	AI173222,Cf-5,Cf5
General protein information	Preferred Names coagulation factor V Names coagulation factor V activated protein C cofactor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 H2.2\|1 71.46 cM
Summary	This gene encodes a glycoprotein coagulation factor that plays a critical role in the process of blood coagulation and hemostasis. The encoded protein is activated by thrombin, to generate a heterodimer containing heavy and light chains held together by calcium ions. About half of the mice lacking the encoded protein die at an embryonic stage possible due to abnormal yolk-sac vasculature while the remaining animals succumbed to massive hemorrhage immediately after birth. A point mutation in this gene has been shown to cause disseminated intravascular thrombosis in the perinatal period, resulting in frequent deaths of newborn mice. [provided by RefSeq, Apr 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_007976.3	NP_032002.1	coagulation factor V preproprotein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	F5	NP_776304.1
Rattus norvegicus (Norway rat)	F5	NP_001041343.1
Gallus gallus (chicken)	F5	XP_001231901.3
Danio rerio (zebrafish)	f5	NP_001007209.2
Mus musculus (house mouse)	F5	NP_032002.1
Pan troglodytes (chimpanzee)	F5	XP_513984.4
Homo sapiens (human)	F5	NP_000121.2
Macaca mulatta (Rhesus monkey)	F5	XP_001093072.2
Canis lupus familiaris (dog)	F5	XP_005622605.1
Xenopus tropicalis (tropical clawed frog)	f5	XP_002935820.2

Gene Ontology
Bibliography

Related articles in PubMed

Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse.
Tomberg K, Westrick RJ, Kotnik EN, Cleuren AC, Siemieniak DR, Zhu G, Saunders TL, Ginsburg D
PLoS genetics14(9)e1007658(2018 09)

Factor V Leiden is associated with increased sperm count.
van Mens TE, Joensen UN, Bochdanovits Z, Takizawa A, Peter J, Jørgensen N, Szecsi PB, Meijers JCM, Weiler H, Rajpert-De Meyts E, Repping S, Middeldorp S
Human reproduction (Oxford, England)32(11)2332-2339(2017 11)

Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci.
Westrick RJ, Tomberg K, Siebert AE, Zhu G, Winn ME, Dobies SL, Manning SL, Brake MA, Cleuren AC, Hobbs LM, Mishack LM, Johnston AJ, Kotnik E, Siemieniak DR, Xu J, Li JZ, Saunders TL, Ginsburg D
Proceedings of the National Academy of Sciences of the United States of America114(36)9659-9664(2017 09)

Platelet-Derived Factor V Is a Critical Mediator of Arterial Thrombosis.
Ren M, Li R, Chen N, Pang N, Li Y, Deng X, Wang L, Luo M, Liu Y, Hao H, Liu Y, Sun H, Wu J
Journal of the American Heart Association6(7)(2017 Jul)

Platelet-derived factor V promotes angiogenesis in a mouse hind limb ischemia model.
Yang Y, Xiao L, Chen N, Li Y, Deng X, Wang L, Sun H, Wu J
Journal of vascular surgery65(4)1180-1188.e1(2017 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following F5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the F5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18711	NM_007976.3 Latest version!	Mus musculus coagulation factor V (F5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	29-31	$1091.30 $1559.00

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

F5 ( NM_007976.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032002.1 Mus musculus coagulation factor V (F5), mRNA.

Price & Availability↑

CloneID	OMu18711
Clone ID Related Accession (Same CDS sequence)	NM_007976.3
Accession Version	NM_007976.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 6552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571587200000
Organism	Mus musculus(house mouse)
Product	coagulation factor V preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK137521.1, AK137537.1, AC157771.8, AC105161.10 and BB799410.1. On Apr 8, 2015 this sequence version replaced NM_007976.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK137537.1, U52925.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCCTAG TCTGCCCGTG CTTCTTCCTC CTGGTGGTTC TGGGAACCCG CTGGGCGGGC 
TGGGGCAGCC ACCAGGCAGA GGCCGCGCAA CTAAGGCAGT TCTATGTGGC AGCTCAGGGG 
ATCCTCTGGA ACTATCATCC TGAGCCCACA GATCCAAGTT TGAATTCTAT ACCTTCCTTC 
AAGAAAATTG TCTACAGAGA GTATGAACAG TATTTTAAGA AAGAAAAGCC ACGATCTAGC 
AACTCAGGAC TTCTTGGACC TACTTTATAC GCTGAAGTTG GGGACGTCAT TAAAGTTCAC 
TTTAGAAACA AAGCAGACAA ACCACTAAGC ATCCATCCTC AAGGGATTAA ATACAGTAAA 
TTTTCAGAAG GGGCTTCTTA CGCAGACCAC ACGTTCCCTG CCGAGAGGAA GGATGATGCC 
GTGGCTCCTG GAGAAGAATA CACCTATGAA TGGATCGTCA GTGAGGACAG CGGGCCCACA 
CCTGATGACC CACCATGCCT CACCCACATC TACTATTCCT ATGAAAACCT GACCCAGGAT 
TTCAACTCGG GTCTGATTGG GCCTCTGCTT ATCTGCAAGA AAGGCACCCT GACCGAGGAT 
GGGACTCAGA AGATGTTTGA CAAGCAGCAT GTGCTCCTAT TTGCTGTGTT TGATGAAAGC 
AAGAGCCGGA GCCAGTCACC ATCCCTAATG TACACAATTA ATGGCTTTGT GAATAAGACG 
ATGCCAGATA TAACAGTCTG TGCCCATGAC CACGTCAGCT GGCATCTGAT CGGGATGAGC 
TCGGGGCCAG AATTGTTTTC TATTCACTTC AACGGCCAAG TCCTAGAGCA GAACCAGCAT 
AAAGTGTCCA CCGTCACCCT GGTCAGCGCA ACATCTACGA CTGCAAACAT GACTATGAGC 
CCAGAAGGAA GATGGATTGT TTCTTCTCTC ATCCCAAAGC ATTATCAAGC TGGGATGCAG 
GCTTACATTG ACATTAAAAA CTGCCCAAAG AAAACGAGGA GCCCCAAGAC CCTCACTCGG 
GAGCAGAGGC GGTACATGAA GAGATGGGAG TATTTCATAG CCGCAGAGGA GGTCATTTGG 
AACTATGCAC CCGTGATACC TGCGAATATG GACAAAATTT ACAGGTCTCA GCACTTGGAT 
AATTTCTCAA ACCAAATTGG AAAACATTAC AAGAAAGTTA TCTACAGGCA ATATGAAGAA 
GAGACCTTCA CCAAACGCAC TGACAACCCC AGCATCAAAC AAAGTGGGAT TCTGGGCCCT 
GTTATCAGAG CCCAGGTCAG AGACACACTC AAGATCGTGT TCAAAAATAT GGCGAGCCGA 
CCCTACAGCA TTTACCCTCA CGGGGTGACC TTCTCTCCTT ACGAAGATGG AATCAATTCT 
TCCTCCACCT CAGGCAGTCA CACCACGATC AGACCAGTTC AACCGGGGGA AACCTTCACT 
TACAAATGGA ACATTCTAGA GTTTGATGAA CCCACGGAAA ACGATGCCCA GTGCCTAACA 
AGGCCATACT ACAGTGATGT GGACGTTACA AGGGATATTG CCTCTGGGCT GATAGGGCTG 
CTTCTAATTT GTAAGAGCAG GTCCCTGGAC CAGAGGGGTG TACAGAGGGT GGCAGACATC 
GAGCAGCAGG CCGTGTTTGC TGTGTTTGAC GAGAACAAGA GCTGGTACAT TGAGGACAAC 
ATCAACAAGT TCTGTGAGAA TCCTGATGAG GTGAAGCGTG ATGATCCCAA GTTTTACGAA 
TCAAACATCA TGAGCACTAT CAACGGCTAC GTGCCCGAGA GCATTTCCAC TCTGGGATTC 
TGTTTTGATG ACACTGTCCA GTGGCACTTC TGCAGTGTGG GAACTCATGA TGATATTTTG 
ACCATCCACT TCACTGGGCA CTCGTTCATC TATGGGAGGA GGCACGAGGA CACCTTGACC 
CTGTTCCCCA TGCGTGGTGA ATCTGTGACA GTTACAATGG ATAATGTTGG AACTTGGATG 
TTGACCACCA TGAATTCCAA TCCAAAACGC AGAAACCTAA GACTGAGATT CAGAGATGTT 
AAGTGTAATC GGGATTATGA CAATGAGGAC TCATATGAGA TTTATGAACC TCCTGCACCT 
ACATCCATGA CAACTCGGAG AATTCATGAT TCCTTAGAAA ATGAATTTGG CATAGACAAC 
GAAGATGATG ATTACCAGTA CTTACTGGCG TCATCATTAG GAATTAGGTC ATTCAAAAAC 
TCATCATTGA ATCCAGAGGA AAATGAGTTC AATCTCACTG CTCTCGCTCT GGAGAACAGC 
TCTGAGTTCA TATCTCCAAG CACAGACAGA GTTGTTGACT CAAACTCTTC ACGAATCCTT 
AGTAAAATCA TCAATAATAA CCTCAAAGAC TTTCAAAGAA CACTTCCTGG CTCAGGAGCC 
ACCGTGGCTG GTACCCTCCT TAGAAACCTC ATTGGCTTAG ATGAGAACTT CGTCCTCAAC 
TCTTCTACAG AACATCGTTC CAGCTCATAT CATGAAAATG ATATGGAAAA TCCACAGTCA 
AACATCACAA TGGTATACCT ACTTCCTCTT GGTCCAAAAG GATCTGGGAA TCGAGAACAA 
GATAAACCTA AAACCATCAA GACAGGAAGA CCCCACATGA TGAAGCACAG GTTCTCCTGG 
ATGAAAGCGC CAGCTGGTAA AACTGGGAGG CATTCAAACC CAAAGAATTC GTATTCTGGA 
ATGAAGTCTG AGGAGGACAT TCCTAGCGAG TTGATACCCT TAAAGCAAAA GATCACTTCC 
AAATTTCTGA ATAGACGATG GCGTGTGGCT TCTGAAAAGG GTAGTTATGA AATAATAGCA 
GCAAATGGTG AAGACACAGA TGTGGATAAG CTGACCAACA GTCCTCAAAA TCAGAATATC 
ACAGTACCTC GGGGAGAGAG CACCTCTCAC ACAAACACAA CAAGAAAGCC AAGTGACCTC 
CCAACATTTT CTGGAGTTGG ACATAAATCT CCACATGTAA GACAGGAGGA AGAAAACAGT 
GGTTTTCAGA AAAGACAGTT ATTCATCAGG ACACGGAAGA AGAAGAAAAA TAAGAAGCTT 
GCACTACACA GTCCTCTATC TCCAAGGGGC TTTGACCCTT TGAGAGGACA TAACCATTCC 
CCATTTCCAG ACAGGAGACT ACTTAATCAC TCACTGTTAC TCCACAAGTC CAATGAAACA 
GCTCTTTCTC CAGACCTGAA CCAGACCTCT CCTTCAATGA GTACGGACAG GTCACTTCCT 
GACTATAATC AGTACTCGAA AAATGACACT GAGCAGATGA GCTCTTCTTT AGATCTTTAT 
CAGTCAGTGC CCGCAGAGGA ACACTCTCCA ACATTTCCTG CCCAAGATCC TGATCAAACA 
CACTCTACCA CAGATCCTAG CTACAGATCC TCTCCGCCAG AGCTCAGCCA GGGGCTTGAT 
TATGACCTAA GTCATGACTT TTACCCTGAT GACATTGGTC TAACATCTTT CTTTCCAGAC 
CAAAGTCAAA AGTCATCTTT CTCTTCAGAT GATGACCAAG CAATCCCTTC CTCAGACTTA 
AGCCTCTTTA CCATCTCTCC AGAATTGGAT CAGACAATTA TTTACCCAGA CCTGGATCAG 
TTGCTCCTTT CTCCAGAAGA CAATCAGAAG ACCTCCTCCC CAGACCTGGG CCAGGTGCCC 
CTTTCTCCAG ATGACAACCA GAAGACCTCC TCCCCAGACC TGGGTCAGGT GTCCCTTTCT 
CCAGATGATA ACCAGAAGAC CTCCTCCCCA GACCTGGGTC AGGTGCCCCT TTCTCTAGAT 
GACAACCAGA AGACGACCTC CCCAGACCTG GGTCAGGTGC CCCTTTCTCC AGATGACAAC 
CAGATGATCA CCTCCCCAGA CCTGGGTCAG GTGCCCCTTT CTTCTGATAA CCAGAAGACC 
TCTTCCCCAG ATCTGGGTCA GGTGCCTCTT TTTCCTGAAG ACAACCAGAA TTACTTCCTA 
GACCTGAGTC AGGTACCTCT CTCCTCAGAC CAAAACCAGG AGACCTCCTC CACAGACCTA 
CTGACTCTCT CTCCTGATTT TGGTCAGACA GTCCTTTCCC CAGACTTGGA TCAGCTGCCA 
CTCCCTTCAG ACAATAGTCA GGTGACCGTT TCCCCAGACC TCAGCCTCTT GACCCTCTCA 
CCAGATTTTA ATGAGATAAT CCTAGCCCCA GACCTTGGTC AAGTGACCCT CTCTCCAGAC 
CTCATCCAGA CAAACCCTGC TCTTAATCAT GGACACAAAG CATCCTCTGC AGACCCTGAT 
CAAGCATCCT ACCCTCCAGA TTCTGGTCAG GCTTCATCGC TTCCAGAACT GAATCGGACT 
CTTCCTCATC CAGATCTCAC TCACATACCA CCTCCTTCAC CATCTCCCAC ACTCAATAAC 
ACTTCTTTGT CAAGGAAATT TAACCCTCTT GTTGTAGTAG GTCTCAGTAG AGTAGATGGA 
GACGACGTTG AGATTGTTCC AAGTGAGGAG CCAGAGAGAA TAGATGAAGA TTATGCCGAG 
GATGACTTTG TAACCTATAA TGACCCCTAC AGAACAGACA CTAGGACAGA TGTCAATTCC 
TCCAGAAATC CTGACACTAT CGCAGCATGG TACCTCCGAG GCCACGGTGG ACACAAAAAA 
TTCTACTATA TTGCAGCTGA AGAAATAACC TGGAATTACG CAGAGTTTGC ACAAAGTGAA 
ATGGACCATG AAGACACAGG CCACACTCCA AAGGACACCA CATACAAGAA AGTCGTTTTC 
AGAAAATACC TTGATAGCAC GTTTACAAGT CGTGATCCTC GGGCAGAATA TGAGGAGCAC 
CTTGGCATTC TCGGTCCTGT GATCCGGGCT GAAGTGGATG ATGTGATCCA AGTTCGATTT 
AAAAATTTGG CATCCAGACC GTATTCTCTT CATGCTCACG GACTTTCCTA TGAAAAATCC 
TCAGAGGGGA AGACTTATGA AGATGAATCT CCTGAATGGT TTCAGGAAGA TGATGCTGTC 
CAGCCCAATA GCAGTTACAC CTATGTATGG CATGCCACCA AGCGCTCAGG GCCAGAGAAC 
CCTGGTTCTG CCTGCCGGGC TTGGGCCTAC TATTCTGCAG TGAATGTGGA GAGGGACATC 
CACTCAGGCT TGATCGGCCC CCTTCTGATC TGCCGGAAAG GAACACTTCA CATGGAGCGC 
AACCTGCCTA TGGACATGAG AGAGTTTGTC TTACTCTTCA TGGTCTTTGA TGAGAAGAAG 
AGCTGGTACT ATGAAAAGTC CAAGGGGTCA CGGAGAATTG AATCCCCAGA AGAGAAAAAT 
GCCCACAAGT TTTACGCAAT TAATGGGATG ATCTACAACC TGCCCGGCCT GAGAATGTAC 
GAGCAAGAGT GGGTGAGGCT ACACCTGCTG AACATGGGCG GCTCCCGAGA TATTCACGTG 
GTTCACTTCC ATGGCCAGAC CCTGCTGGAT AATAGGACCA AACAGCACCA GTTAGGCGTC 
TGGCCCCTTC TGCCTGGTTC ATTTAAAACT CTTGAAATGA AGGCATCCAA GCCTGGCTGG 
TGGCTCCTAG ACACAGAGGT TGGAGAAAAC CAGGTAGCTG GCATGCAAAC GCCATTTCTC 
ATCATAGACA AAGAGTGTAA GATGCCAATG GGACTAAGCA CTGGTGTCAT ATCTGATTCA 
CAGATCAAGG CTTCGGAATA TCTGACTTAT TGGGAGCCCA GATTAGCACG ATTAAACAAT 
GCTGGTTCAT ACAATGCTTG GAGTATAGAA AAAACTGCAT TAGATTTTCC CATTAAACCT 
TGGATCCAGG TGGACATGCA GAAGGAAGTT GTAGTCACCG GGATACAAAC CCAAGGTGCT 
AAACACTACC TAAAGTCCTG CTTTACCACG GAGTTCCAAG TGGCTTACAG CTCTGACCAA 
ACCAACTGGC AGATCTTCAG AGGGAAGAGC GGGAAGAGCG TGATGTATTT TACTGGTAAT 
TCAGATGGCT CTACAATAAA AGAGAATCGA CTTGACCCAC CCATTGTGGC TAGATACATT 
AGGATACACC CAACAAAATC CTATAATAGA CCCACCCTTC GGCTGGAGCT GCAGGGCTGT 
GAGGTGAACG GATGTTCCAC ACCACTGGGC CTGGAAGATG GACGGATTCA AGACAAGCAA 
ATTACTGCAT CTTCATTTAA AAAGTCGTGG TGGGGAGACT ACTGGGAGCC CTCCCTTGCC 
CGCCTGAACG CCCAGGGCCG CGTGAACGCC TGGCAAGCCA AGGCAAACAA CAACAAGCAG 
TGGTTACAAG TCGATCTGCT CAAAATCAAG AAGGTAACGG CCATCGTAAC GCAGGGCTGT 
AAGTCTCTGT CCTCTGAGAT GTACGTGAAG AGCTACAGCA TCCAGTACAG TGACCAGGGT 
GTGGCATGGA AACCTTACCG ACAGAAATCC TCCATGGTGG ACAAGATTTT TGAAGGAAAC 
AGCAATACCA AGGGGCACAT GAAGAACTTT TTCAACCCGC CCATTATTTC CAGATTTATC 
CGCATCATTC CTAAAACATG GAACCAGAGC ATCGCCCTTC GCCTAGAGCT CTTCGGCTGT 
GACATTTATT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032002.1
CDS	129..6680
Translation	MLLVCPCFFLLVVLGTRWAGWGSHQAEAAQLRQFYVAAQGILWNYHPEPTDPSLNSIPSFKKIVYREYEQYFKKEKPRSSNSGLLGPTLYAEVGDVIKVHFRNKADKPLSIHPQGIKYSKFSEGASYADHTFPAERKDDAVAPGEEYTYEWIVSEDSGPTPDDPPCLTHIYYSYENLTQDFNSGLIGPLLICKKGTLTEDGTQKMFDKQHVLLFAVFDESKSRSQSPSLMYTINGFVNKTMPDITVCAHDHVSWHLIGMSSGPELFSIHFNGQVLEQNQHKVSTVTLVSATSTTANMTMSPEGRWIVSSLIPKHYQAGMQAYIDIKNCPKKTRSPKTLTREQRRYMKRWEYFIAAEEVIWNYAPVIPANMDKIYRSQHLDNFSNQIGKHYKKVIYRQYEEETFTKRTDNPSIKQSGILGPVIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDGINSSSTSGSHTTIRPVQPGETFTYKWNILEFDEPTENDAQCLTRPYYSDVDVTRDIASGLIGLLLICKSRSLDQRGVQRVADIEQQAVFAVFDENKSWYIEDNINKFCENPDEVKRDDPKFYESNIMSTINGYVPESISTLGFCFDDTVQWHFCSVGTHDDILTIHFTGHSFIYGRRHEDTLTLFPMRGESVTVTMDNVGTWMLTTMNSNPKRRNLRLRFRDVKCNRDYDNEDSYEIYEPPAPTSMTTRRIHDSLENEFGIDNEDDDYQYLLASSLGIRSFKNSSLNPEENEFNLTALALENSSEFISPSTDRVVDSNSSRILSKIINNNLKDFQRTLPGSGATVAGTLLRNLIGLDENFVLNSSTEHRSSSYHENDMENPQSNITMVYLLPLGPKGSGNREQDKPKTIKTGRPHMMKHRFSWMKAPAGKTGRHSNPKNSYSGMKSEEDIPSELIPLKQKITSKFLNRRWRVASEKGSYEIIAANGEDTDVDKLTNSPQNQNITVPRGESTSHTNTTRKPSDLPTFSGVGHKSPHVRQEEENSGFQKRQLFIRTRKKKKNKKLALHSPLSPRGFDPLRGHNHSPFPDRRLLNHSLLLHKSNETALSPDLNQTSPSMSTDRSLPDYNQYSKNDTEQMSSSLDLYQSVPAEEHSPTFPAQDPDQTHSTTDPSYRSSPPELSQGLDYDLSHDFYPDDIGLTSFFPDQSQKSSFSSDDDQAIPSSDLSLFTISPELDQTIIYPDLDQLLLSPEDNQKTSSPDLGQVPLSPDDNQKTSSPDLGQVSLSPDDNQKTSSPDLGQVPLSLDDNQKTTSPDLGQVPLSPDDNQMITSPDLGQVPLSSDNQKTSSPDLGQVPLFPEDNQNYFLDLSQVPLSSDQNQETSSTDLLTLSPDFGQTVLSPDLDQLPLPSDNSQVTVSPDLSLLTLSPDFNEIILAPDLGQVTLSPDLIQTNPALNHGHKASSADPDQASYPPDSGQASSLPELNRTLPHPDLTHIPPPSPSPTLNNTSLSRKFNPLVVVGLSRVDGDDVEIVPSEEPERIDEDYAEDDFVTYNDPYRTDTRTDVNSSRNPDTIAAWYLRGHGGHKKFYYIAAEEITWNYAEFAQSEMDHEDTGHTPKDTTYKKVVFRKYLDSTFTSRDPRAEYEEHLGILGPVIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDESPEWFQEDDAVQPNSSYTYVWHATKRSGPENPGSACRAWAYYSAVNVERDIHSGLIGPLLICRKGTLHMERNLPMDMREFVLLFMVFDEKKSWYYEKSKGSRRIESPEEKNAHKFYAINGMIYNLPGLRMYEQEWVRLHLLNMGGSRDIHVVHFHGQTLLDNRTKQHQLGVWPLLPGSFKTLEMKASKPGWWLLDTEVGENQVAGMQTPFLIIDKECKMPMGLSTGVISDSQIKASEYLTYWEPRLARLNNAGSYNAWSIEKTALDFPIKPWIQVDMQKEVVVTGIQTQGAKHYLKSCFTTEFQVAYSSDQTNWQIFRGKSGKSVMYFTGNSDGSTIKENRLDPPIVARYIRIHPTKSYNRPTLRLELQGCEVNGCSTPLGLEDGRIQDKQITASSFKKSWWGDYWEPSLARLNAQGRVNAWQAKANNNKQWLQVDLLKIKKVTAIVTQGCKSLSSEMYVKSYSIQYSDQGVAWKPYRQKSSMVDKIFEGNSNTKGHMKNFFNPPIISRFIRIIPKTWNQSIALRLELFGCDIY

Target ORF information:

RefSeq Version	NM_007976.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus coagulation factor V (F5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007976.3

ORF Insert Sequence:

ATGCTCCTAG TCTGCCCGTG CTTCTTCCTC CTGGTGGTTC TGGGAACCCG CTGGGCGGGC 
TGGGGCAGCC ACCAGGCAGA GGCCGCGCAA CTAAGGCAGT TCTATGTGGC AGCTCAGGGG 
ATCCTCTGGA ACTATCATCC TGAGCCCACA GATCCAAGTT TGAATTCTAT ACCTTCCTTC 
AAGAAAATTG TCTACAGAGA GTATGAACAG TATTTTAAGA AAGAAAAGCC ACGATCTAGC 
AACTCAGGAC TTCTTGGACC TACTTTATAC GCTGAAGTTG GGGACGTCAT TAAAGTTCAC 
TTTAGAAACA AAGCAGACAA ACCACTAAGC ATCCATCCTC AAGGGATTAA ATACAGTAAA 
TTTTCAGAAG GGGCTTCTTA CGCAGACCAC ACGTTCCCTG CCGAGAGGAA GGATGATGCC 
GTGGCTCCTG GAGAAGAATA CACCTATGAA TGGATCGTCA GTGAGGACAG CGGGCCCACA 
CCTGATGACC CACCATGCCT CACCCACATC TACTATTCCT ATGAAAACCT GACCCAGGAT 
TTCAACTCGG GTCTGATTGG GCCTCTGCTT ATCTGCAAGA AAGGCACCCT GACCGAGGAT 
GGGACTCAGA AGATGTTTGA CAAGCAGCAT GTGCTCCTAT TTGCTGTGTT TGATGAAAGC 
AAGAGCCGGA GCCAGTCACC ATCCCTAATG TACACAATTA ATGGCTTTGT GAATAAGACG 
ATGCCAGATA TAACAGTCTG TGCCCATGAC CACGTCAGCT GGCATCTGAT CGGGATGAGC 
TCGGGGCCAG AATTGTTTTC TATTCACTTC AACGGCCAAG TCCTAGAGCA GAACCAGCAT 
AAAGTGTCCA CCGTCACCCT GGTCAGCGCA ACATCTACGA CTGCAAACAT GACTATGAGC 
CCAGAAGGAA GATGGATTGT TTCTTCTCTC ATCCCAAAGC ATTATCAAGC TGGGATGCAG 
GCTTACATTG ACATTAAAAA CTGCCCAAAG AAAACGAGGA GCCCCAAGAC CCTCACTCGG 
GAGCAGAGGC GGTACATGAA GAGATGGGAG TATTTCATAG CCGCAGAGGA GGTCATTTGG 
AACTATGCAC CCGTGATACC TGCGAATATG GACAAAATTT ACAGGTCTCA GCACTTGGAT 
AATTTCTCAA ACCAAATTGG AAAACATTAC AAGAAAGTTA TCTACAGGCA ATATGAAGAA 
GAGACCTTCA CCAAACGCAC TGACAACCCC AGCATCAAAC AAAGTGGGAT TCTGGGCCCT 
GTTATCAGAG CCCAGGTCAG AGACACACTC AAGATCGTGT TCAAAAATAT GGCGAGCCGA 
CCCTACAGCA TTTACCCTCA CGGGGTGACC TTCTCTCCTT ACGAAGATGG AATCAATTCT 
TCCTCCACCT CAGGCAGTCA CACCACGATC AGACCAGTTC AACCGGGGGA AACCTTCACT 
TACAAATGGA ACATTCTAGA GTTTGATGAA CCCACGGAAA ACGATGCCCA GTGCCTAACA 
AGGCCATACT ACAGTGATGT GGACGTTACA AGGGATATTG CCTCTGGGCT GATAGGGCTG 
CTTCTAATTT GTAAGAGCAG GTCCCTGGAC CAGAGGGGTG TACAGAGGGT GGCAGACATC 
GAGCAGCAGG CCGTGTTTGC TGTGTTTGAC GAGAACAAGA GCTGGTACAT TGAGGACAAC 
ATCAACAAGT TCTGTGAGAA TCCTGATGAG GTGAAGCGTG ATGATCCCAA GTTTTACGAA 
TCAAACATCA TGAGCACTAT CAACGGCTAC GTGCCCGAGA GCATTTCCAC TCTGGGATTC 
TGTTTTGATG ACACTGTCCA GTGGCACTTC TGCAGTGTGG GAACTCATGA TGATATTTTG 
ACCATCCACT TCACTGGGCA CTCGTTCATC TATGGGAGGA GGCACGAGGA CACCTTGACC 
CTGTTCCCCA TGCGTGGTGA ATCTGTGACA GTTACAATGG ATAATGTTGG AACTTGGATG 
TTGACCACCA TGAATTCCAA TCCAAAACGC AGAAACCTAA GACTGAGATT CAGAGATGTT 
AAGTGTAATC GGGATTATGA CAATGAGGAC TCATATGAGA TTTATGAACC TCCTGCACCT 
ACATCCATGA CAACTCGGAG AATTCATGAT TCCTTAGAAA ATGAATTTGG CATAGACAAC 
GAAGATGATG ATTACCAGTA CTTACTGGCG TCATCATTAG GAATTAGGTC ATTCAAAAAC 
TCATCATTGA ATCCAGAGGA AAATGAGTTC AATCTCACTG CTCTCGCTCT GGAGAACAGC 
TCTGAGTTCA TATCTCCAAG CACAGACAGA GTTGTTGACT CAAACTCTTC ACGAATCCTT 
AGTAAAATCA TCAATAATAA CCTCAAAGAC TTTCAAAGAA CACTTCCTGG CTCAGGAGCC 
ACCGTGGCTG GTACCCTCCT TAGAAACCTC ATTGGCTTAG ATGAGAACTT CGTCCTCAAC 
TCTTCTACAG AACATCGTTC CAGCTCATAT CATGAAAATG ATATGGAAAA TCCACAGTCA 
AACATCACAA TGGTATACCT ACTTCCTCTT GGTCCAAAAG GATCTGGGAA TCGAGAACAA 
GATAAACCTA AAACCATCAA GACAGGAAGA CCCCACATGA TGAAGCACAG GTTCTCCTGG 
ATGAAAGCGC CAGCTGGTAA AACTGGGAGG CATTCAAACC CAAAGAATTC GTATTCTGGA 
ATGAAGTCTG AGGAGGACAT TCCTAGCGAG TTGATACCCT TAAAGCAAAA GATCACTTCC 
AAATTTCTGA ATAGACGATG GCGTGTGGCT TCTGAAAAGG GTAGTTATGA AATAATAGCA 
GCAAATGGTG AAGACACAGA TGTGGATAAG CTGACCAACA GTCCTCAAAA TCAGAATATC 
ACAGTACCTC GGGGAGAGAG CACCTCTCAC ACAAACACAA CAAGAAAGCC AAGTGACCTC 
CCAACATTTT CTGGAGTTGG ACATAAATCT CCACATGTAA GACAGGAGGA AGAAAACAGT 
GGTTTTCAGA AAAGACAGTT ATTCATCAGG ACACGGAAGA AGAAGAAAAA TAAGAAGCTT 
GCACTACACA GTCCTCTATC TCCAAGGGGC TTTGACCCTT TGAGAGGACA TAACCATTCC 
CCATTTCCAG ACAGGAGACT ACTTAATCAC TCACTGTTAC TCCACAAGTC CAATGAAACA 
GCTCTTTCTC CAGACCTGAA CCAGACCTCT CCTTCAATGA GTACGGACAG GTCACTTCCT 
GACTATAATC AGTACTCGAA AAATGACACT GAGCAGATGA GCTCTTCTTT AGATCTTTAT 
CAGTCAGTGC CCGCAGAGGA ACACTCTCCA ACATTTCCTG CCCAAGATCC TGATCAAACA 
CACTCTACCA CAGATCCTAG CTACAGATCC TCTCCGCCAG AGCTCAGCCA GGGGCTTGAT 
TATGACCTAA GTCATGACTT TTACCCTGAT GACATTGGTC TAACATCTTT CTTTCCAGAC 
CAAAGTCAAA AGTCATCTTT CTCTTCAGAT GATGACCAAG CAATCCCTTC CTCAGACTTA 
AGCCTCTTTA CCATCTCTCC AGAATTGGAT CAGACAATTA TTTACCCAGA CCTGGATCAG 
TTGCTCCTTT CTCCAGAAGA CAATCAGAAG ACCTCCTCCC CAGACCTGGG CCAGGTGCCC 
CTTTCTCCAG ATGACAACCA GAAGACCTCC TCCCCAGACC TGGGTCAGGT GTCCCTTTCT 
CCAGATGATA ACCAGAAGAC CTCCTCCCCA GACCTGGGTC AGGTGCCCCT TTCTCTAGAT 
GACAACCAGA AGACGACCTC CCCAGACCTG GGTCAGGTGC CCCTTTCTCC AGATGACAAC 
CAGATGATCA CCTCCCCAGA CCTGGGTCAG GTGCCCCTTT CTTCTGATAA CCAGAAGACC 
TCTTCCCCAG ATCTGGGTCA GGTGCCTCTT TTTCCTGAAG ACAACCAGAA TTACTTCCTA 
GACCTGAGTC AGGTACCTCT CTCCTCAGAC CAAAACCAGG AGACCTCCTC CACAGACCTA 
CTGACTCTCT CTCCTGATTT TGGTCAGACA GTCCTTTCCC CAGACTTGGA TCAGCTGCCA 
CTCCCTTCAG ACAATAGTCA GGTGACCGTT TCCCCAGACC TCAGCCTCTT GACCCTCTCA 
CCAGATTTTA ATGAGATAAT CCTAGCCCCA GACCTTGGTC AAGTGACCCT CTCTCCAGAC 
CTCATCCAGA CAAACCCTGC TCTTAATCAT GGACACAAAG CATCCTCTGC AGACCCTGAT 
CAAGCATCCT ACCCTCCAGA TTCTGGTCAG GCTTCATCGC TTCCAGAACT GAATCGGACT 
CTTCCTCATC CAGATCTCAC TCACATACCA CCTCCTTCAC CATCTCCCAC ACTCAATAAC 
ACTTCTTTGT CAAGGAAATT TAACCCTCTT GTTGTAGTAG GTCTCAGTAG AGTAGATGGA 
GACGACGTTG AGATTGTTCC AAGTGAGGAG CCAGAGAGAA TAGATGAAGA TTATGCCGAG 
GATGACTTTG TAACCTATAA TGACCCCTAC AGAACAGACA CTAGGACAGA TGTCAATTCC 
TCCAGAAATC CTGACACTAT CGCAGCATGG TACCTCCGAG GCCACGGTGG ACACAAAAAA 
TTCTACTATA TTGCAGCTGA AGAAATAACC TGGAATTACG CAGAGTTTGC ACAAAGTGAA 
ATGGACCATG AAGACACAGG CCACACTCCA AAGGACACCA CATACAAGAA AGTCGTTTTC 
AGAAAATACC TTGATAGCAC GTTTACAAGT CGTGATCCTC GGGCAGAATA TGAGGAGCAC 
CTTGGCATTC TCGGTCCTGT GATCCGGGCT GAAGTGGATG ATGTGATCCA AGTTCGATTT 
AAAAATTTGG CATCCAGACC GTATTCTCTT CATGCTCACG GACTTTCCTA TGAAAAATCC 
TCAGAGGGGA AGACTTATGA AGATGAATCT CCTGAATGGT TTCAGGAAGA TGATGCTGTC 
CAGCCCAATA GCAGTTACAC CTATGTATGG CATGCCACCA AGCGCTCAGG GCCAGAGAAC 
CCTGGTTCTG CCTGCCGGGC TTGGGCCTAC TATTCTGCAG TGAATGTGGA GAGGGACATC 
CACTCAGGCT TGATCGGCCC CCTTCTGATC TGCCGGAAAG GAACACTTCA CATGGAGCGC 
AACCTGCCTA TGGACATGAG AGAGTTTGTC TTACTCTTCA TGGTCTTTGA TGAGAAGAAG 
AGCTGGTACT ATGAAAAGTC CAAGGGGTCA CGGAGAATTG AATCCCCAGA AGAGAAAAAT 
GCCCACAAGT TTTACGCAAT TAATGGGATG ATCTACAACC TGCCCGGCCT GAGAATGTAC 
GAGCAAGAGT GGGTGAGGCT ACACCTGCTG AACATGGGCG GCTCCCGAGA TATTCACGTG 
GTTCACTTCC ATGGCCAGAC CCTGCTGGAT AATAGGACCA AACAGCACCA GTTAGGCGTC 
TGGCCCCTTC TGCCTGGTTC ATTTAAAACT CTTGAAATGA AGGCATCCAA GCCTGGCTGG 
TGGCTCCTAG ACACAGAGGT TGGAGAAAAC CAGGTAGCTG GCATGCAAAC GCCATTTCTC 
ATCATAGACA AAGAGTGTAA GATGCCAATG GGACTAAGCA CTGGTGTCAT ATCTGATTCA 
CAGATCAAGG CTTCGGAATA TCTGACTTAT TGGGAGCCCA GATTAGCACG ATTAAACAAT 
GCTGGTTCAT ACAATGCTTG GAGTATAGAA AAAACTGCAT TAGATTTTCC CATTAAACCT 
TGGATCCAGG TGGACATGCA GAAGGAAGTT GTAGTCACCG GGATACAAAC CCAAGGTGCT 
AAACACTACC TAAAGTCCTG CTTTACCACG GAGTTCCAAG TGGCTTACAG CTCTGACCAA 
ACCAACTGGC AGATCTTCAG AGGGAAGAGC GGGAAGAGCG TGATGTATTT TACTGGTAAT 
TCAGATGGCT CTACAATAAA AGAGAATCGA CTTGACCCAC CCATTGTGGC TAGATACATT 
AGGATACACC CAACAAAATC CTATAATAGA CCCACCCTTC GGCTGGAGCT GCAGGGCTGT 
GAGGTGAACG GATGTTCCAC ACCACTGGGC CTGGAAGATG GACGGATTCA AGACAAGCAA 
ATTACTGCAT CTTCATTTAA AAAGTCGTGG TGGGGAGACT ACTGGGAGCC CTCCCTTGCC 
CGCCTGAACG CCCAGGGCCG CGTGAACGCC TGGCAAGCCA AGGCAAACAA CAACAAGCAG 
TGGTTACAAG TCGATCTGCT CAAAATCAAG AAGGTAACGG CCATCGTAAC GCAGGGCTGT 
AAGTCTCTGT CCTCTGAGAT GTACGTGAAG AGCTACAGCA TCCAGTACAG TGACCAGGGT 
GTGGCATGGA AACCTTACCG ACAGAAATCC TCCATGGTGG ACAAGATTTT TGAAGGAAAC 
AGCAATACCA AGGGGCACAT GAAGAACTTT TTCAACCCGC CCATTATTTC CAGATTTATC 
CGCATCATTC CTAAAACATG GAACCAGAGC ATCGCCCTTC GCCTAGAGCT CTTCGGCTGT 
GACATTTATT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse.
PLoS genetics14(9)e1007658(2018 09)
Tomberg K,Westrick RJ,Kotnik EN,Cleuren AC,Siemieniak DR,Zhu G,Saunders TL,Ginsburg D

Factor V Leiden is associated with increased sperm count.
Human reproduction (Oxford, England)32(11)2332-2339(2017 11)
van Mens TE,Joensen UN,Bochdanovits Z,Takizawa A,Peter J,Jørgensen N,Szecsi PB,Meijers JCM,Weiler H,Rajpert-De Meyts E,Repping S,Middeldorp S

Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci.
Proceedings of the National Academy of Sciences of the United States of America114(36)9659-9664(2017 09)
Westrick RJ,Tomberg K,Siebert AE,Zhu G,Winn ME,Dobies SL,Manning SL,Brake MA,Cleuren AC,Hobbs LM,Mishack LM,Johnston AJ,Kotnik E,Siemieniak DR,Xu J,Li JZ,Saunders TL,Ginsburg D

Platelet-Derived Factor V Is a Critical Mediator of Arterial Thrombosis.
Journal of the American Heart Association6(7)(2017 Jul)
Ren M,Li R,Chen N,Pang N,Li Y,Deng X,Wang L,Luo M,Liu Y,Hao H,Liu Y,Sun H,Wu J

Platelet-derived factor V promotes angiogenesis in a mouse hind limb ischemia model.
Journal of vascular surgery65(4)1180-1188.e1(2017 04)
Yang Y,Xiao L,Chen N,Li Y,Deng X,Wang L,Sun H,Wu J

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F5 cDNA ORF clone, Mus musculus(house mouse)

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