IFIH1 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	IFIH1
Entrez Gene ID	424185
Full Name	interferon induced with helicase C domain 1
Synonyms	MDA5
General protein information	Preferred Names interferon induced with helicase C domain 1 Names interferon-induced helicase C domain-containing protein 1 melanoma differentiation-associated protein 5
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001193638.1	NP_001180567.1	interferon-induced helicase C domain-containing protein 1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	LOC565759	XP_694124.4
Bos taurus (cattle)	IFIH1	XP_002685384.1
Mus musculus (house mouse)	Ifih1	NP_082111.2
Rattus norvegicus (Norway rat)	Ifih1	NP_001102669.1
Homo sapiens (human)	IFIH1	NP_071451.2
Pan troglodytes (chimpanzee)	IFIH1	XP_003309348.1
Macaca mulatta (Rhesus monkey)	IFIH1	NP_001040588.1
Canis lupus familiaris (dog)	IFIH1	XP_545493.2
Gallus gallus (chicken)	IFIH1	NP_001180567.1
Xenopus tropicalis (tropical clawed frog)	ifih1	XP_002933320.2

Gene Ontology
Bibliography

Related articles in PubMed

Altered gene expression profiles of the MDA5 signaling pathway in peripheral blood lymphocytes of chickens infected with avian reovirus.
Xie L, Xie Z, Wang S, Huang J, Deng X, Xie Z, Luo S, Zeng T, Zhang Y, Zhang M
Archives of virology164(10)2451-2458(2019 Oct)

Avian infectious bronchitis virus disrupts the melanoma differentiation associated gene 5 (MDA5) signaling pathway by cleavage of the adaptor protein MAVS.
Yu L, Zhang X, Wu T, Su J, Wang Y, Wang Y, Ruan B, Niu X, Wu Y
BMC veterinary research13(1)332(2017 Nov)

MiR-34b-5p Suppresses Melanoma Differentiation-Associated Gene 5 (
Li Z, Luo Q, Xu H, Zheng M, Abdalla BA, Feng M, Cai B, Zhang X, Nie Q, Zhang X
Frontiers in cellular and infection microbiology717(2017)

Promoter structures and differential responses to viral and non-viral inducers of chicken melanoma differentiation-associated gene 5.
Zhang WX, Zuo EW, He Y, Chen DY, Long X, Chen MJ, Li TT, Yang XG, Xu HY, Lu SS, Zhang M, Lu KH, Lu YQ
Molecular immunology761-6(2016 08)

Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
Uchikawa E, Lethier M, Malet H, Brunel J, Gerlier D, Cusack S
Molecular cell62(4)586-602(2016 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following IFIH1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFIH1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa26441	NM_001193638.1 Latest version!	Gallus gallus interferon induced with helicase C domain 1 (IFIH1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IFIH1 ( NM_001193638.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001180567.1 Gallus gallus interferon induced with helicase C domain 1 (IFIH1), mRNA.

Price & Availability↑

CloneID	OGa26441
Clone ID Related Accession (Same CDS sequence)	NM_001193638.1
Accession Version	NM_001193638.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3006bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569254400000
Organism	Gallus gallus(chicken)
Product	interferon-induced helicase C domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB371640.1. On Aug 8, 2010 this sequence version replaced XM_422031.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB371640.1, JN376086.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END##

ATGTCGGAGG AGTGCCGAGA CGAGCGCTTC CTCTACATGA TCTCCTGCTT CAGGCCGCGG 
CTGAAGCGCT GCATCCGGGT GCAGCCGGTG CTGGACTGGC TGCCCTCGCT GAGCGCAGAG 
GAGAAGGACA AGGTGCGGGC GGCCGCGCTG CAGCGCGGCG AGGTGGAGGG GGCCGAGGAG 
CTGCTATGCG CCGTGGAACG TGGCCGCCGC GACCCCGGAT GGTTCACTGA ATTCCTGCTG 
GCGCTGAAGA AAGGCGGCTG TGACCTGGCC GCTTGCTACG TGAACCCCAG CCAGTTGCCC 
TCGCCTCAGG AGGAGGACGA CCACGATCTC TGTGTGCACT TGGTGCAGCT GCTGCACGGC 
ACGCTGGTGG ATAACATGCA GACCAGACAG GTGGCCGAGA AGTGTCTGGA GCTGGGCATC 
TTCCAGGAGG AGGACCTGGT TGGGATTGAG ACTGTTATTG AGAGTCGTGG GAACAGAGAC 
GGTGCAAGGG AGCTGTTGAG CAGAATAGTG CAGAAGAAGG ACTGGTTCTC TCAGTTTTTG 
GTTGCTCTGC GAGAAACCCA ACATGAAAGC CTTGCAGATG ACTTAAGTGG AAATACAGGA 
GGAACAGAGG ATAAAGACTA TGAGTTGAAG AACAACACAG GCAAAAAAAC AGAAGCTGCA 
AGCCAACCAG TATATGTAAC GGAGGATTTG AAACAGCAAG AAAATTTGGA TGACAGTTTT 
GTCAGAGAGA GCAGTGTATT GGAAACATCT GTTGGAAAGA ACTCTGTAAT TTCAGAATCA 
GTTGCTGTAG GAGATGCAAG TGTCAGTAAC TCGAACGAAA ACCTGGGACA GAGCAGCACG 
ACCAGTGATT CAGGTGAAGA TGAAGCAGAG GGCAGAGCTT CACCTGAGCC AGATCTCACC 
CTGAGAGATT ACCAGATGGA AGTTGCAAAA CCAGCACTGA ATGGGGAGAA TATTATAATA 
TGTCTCCCTA CAGGCAGTGG CAAAACCAGA GTGGCTGTTT ACATTACCAA AGATCACTTG 
GATAAGAAGA GAAAAGCATC AGAGCAAGGA AAAGTTATAG TACTTGTTAA TAAGGTACCG 
TTAGTGGAAC AGCATTTACG AAAGGAGTTT AATCCATTCC TGAAACACTG GTATCAAGTT 
ATTGGCTTAA GTGGTGATTC TGAGCTGAAA ATCTCGTTTC CTGAAGTTGT CAAAAGATAT 
GATGTCATCA TCTGTACAGC ACAGATCCTG GAGAATTCAC TGCTAAATGC AACTGAAGAA 
GATGAAAGTG TCCGCTTGTC AGATTTTTCA CTCATCATTA TTGATGAGTG CCATCACACT 
CAAAAGGAAG GTGTTTACAA CAATATCATG CGACGTTACT TAAAAGAAAA GATCAAGAAC 
AGAAAGCAGG CAAAAGAGAA CAAACCTTTG ATTCCACAGC CGCAGATTCT GGGACTTACA 
GCCTCACCTG GAGTTGGAGG TGCAAGATCC AACTCAAAAG CTGAAGAACA TATTCTGAAA 
ATCTGTGCCA ATCTTGATGC ATGCAGAATC ATGACTGTTA AAGAGCATGC ATCCCAACTG 
AAGAATCAGG TGAAGGAACC ATTTAAGAAG ACTGTGATTG CAGATGACAA AAGAAGGGAT 
CCATTTAGAG AAAGAATTAT TGAGATCATG CAAGATATTC AAAAATATTG CCAGCTCTAT 
CCAAAATCTG AGTTTGGATC TCAGCCATAT GAACAGTGGG TGATTAGGGA AGAGAGAAGA 
GCTGCAAAAG AAGAAAAACG CAAGGAACGT GTCTGTGCAG AACACTTGAA GAAATATAAT 
GATGCTCTGC AAATTAATGA TACCATTCGA ATGGTTGATG CATACAATCA CCTAAATAAC 
TTTTATAAGG AGCTAAAAAG GAGGAAGACA GCGGAGAGTG ATGATGATGA AGAACCATTA 
GTATCAAAAC AGGATGAAAC AGATGAATTT TTAATGCGTT TATTTCATGC AAAAAAGAAA 
CAACTGAAAG AGTTGGCTAG AAAACCAGAA TATGACAATG AGAAGCTAAT GAAGCTCCGG 
AATACTTTAA TGGAAGAGTT CACAAAGACT GAAGAACCTA GAGGGATTAT TTTCACGAAG 
ACTCGACAAA GTGCCTTAGC TTTATACCAC TGGATTATGG ATAATCCAAA ATTTGAAGAA 
GTGGGAATCA AAGCTCATTT TCTTATTGGT GCTGGACACA ATAGTGAAAC TAAACCTATG 
ACTCAGAATG AGCAAAGGGA AGTCATTGAT AAATTCCGAG GTGGAAGTAT AAATTTACTT 
ATTGCTACTA CTGTAGCTGA GGAAGGCCTA GACATCAAAG AGTGTAACAT TGTTATTCGC 
TATGGTCTGG TCACCAATGA AATTGCTATG GTGCAGGCCC GGGGTCGAGC TCGAGCTGAT 
GAGAGCACTT ATGCACTTGT GGCTTCAAGT GGCTCAGGAG CTGTTGAACG TGAAGATGTA 
AATATTTTCC GTGAAAATAT GATGTATAAG GCCATTCGAC GTGTCCAAGA GATGCCGCCA 
GAAGAGTATT TAAATAAGAT TCAGGACTTC CAGTTGCAAA GCATAGTGGA AAAACAAATG 
AAGGCAAAGA GAGATCAGCG TAAGACATAT AAGAAAAACC CTTCACTAAT AACATTCCTG 
TGCAAGAATT GCCACAAGTT GATATGTTCT GGAGAAGATA TACAAGTTAT TGAAAATATG 
CATCATGTCA GTGTGAAAAA AGATTTCCAA CATCTTTACC ATAAAAGAGA AAACAGGACA 
TTGCAAGACA AGCATGCTGA TTACCAGACA AACGTGGAAA TTATATGTAA AGATTGTGGA 
CAAGTTTGGG GAAATATGAT GGTTTATCGA GGTCTTGACC TGCCTTGTCT AAAGATTAGA 
AATTTTGTGG TTGCTTTTGA AGACAAGAAA ACAACAAAGG AAATTTTCAA GAAATGGGGA 
GAACTGCCCA TCATATTTCC TGATTTTGAT TATGCATCTC ATTGTCCTTC AAGTGATGAA 
GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001180567.1
CDS	143..3148
Translation	MSEECRDERFLYMISCFRPRLKRCIRVQPVLDWLPSLSAEEKDKVRAAALQRGEVEGAEELLCAVERGRRDPGWFTEFLLALKKGGCDLAACYVNPSQLPSPQEEDDHDLCVHLVQLLHGTLVDNMQTRQVAEKCLELGIFQEEDLVGIETVIESRGNRDGARELLSRIVQKKDWFSQFLVALRETQHESLADDLSGNTGGTEDKDYELKNNTGKKTEAASQPVYVTEDLKQQENLDDSFVRESSVLETSVGKNSVISESVAVGDASVSNSNENLGQSSTTSDSGEDEAEGRASPEPDLTLRDYQMEVAKPALNGENIIICLPTGSGKTRVAVYITKDHLDKKRKASEQGKVIVLVNKVPLVEQHLRKEFNPFLKHWYQVIGLSGDSELKISFPEVVKRYDVIICTAQILENSLLNATEEDESVRLSDFSLIIIDECHHTQKEGVYNNIMRRYLKEKIKNRKQAKENKPLIPQPQILGLTASPGVGGARSNSKAEEHILKICANLDACRIMTVKEHASQLKNQVKEPFKKTVIADDKRRDPFRERIIEIMQDIQKYCQLYPKSEFGSQPYEQWVIREERRAAKEEKRKERVCAEHLKKYNDALQINDTIRMVDAYNHLNNFYKELKRRKTAESDDDEEPLVSKQDETDEFLMRLFHAKKKQLKELARKPEYDNEKLMKLRNTLMEEFTKTEEPRGIIFTKTRQSALALYHWIMDNPKFEEVGIKAHFLIGAGHNSETKPMTQNEQREVIDKFRGGSINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYALVASSGSGAVEREDVNIFRENMMYKAIRRVQEMPPEEYLNKIQDFQLQSIVEKQMKAKRDQRKTYKKNPSLITFLCKNCHKLICSGEDIQVIENMHHVSVKKDFQHLYHKRENRTLQDKHADYQTNVEIICKDCGQVWGNMMVYRGLDLPCLKIRNFVVAFEDKKTTKEIFKKWGELPIIFPDFDYASHCPSSDED

Target ORF information:

RefSeq Version	NM_001193638.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus interferon induced with helicase C domain 1 (IFIH1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001193638.1

ORF Insert Sequence:

ATGTCGGAGG AGTGCCGAGA CGAGCGCTTC CTCTACATGA TCTCCTGCTT CAGGCCGCGG 
CTGAAGCGCT GCATCCGGGT GCAGCCGGTG CTGGACTGGC TGCCCTCGCT GAGCGCAGAG 
GAGAAGGACA AGGTGCGGGC GGCCGCGCTG CAGCGCGGCG AGGTGGAGGG GGCCGAGGAG 
CTGCTATGCG CCGTGGAACG TGGCCGCCGC GACCCCGGAT GGTTCACTGA ATTCCTGCTG 
GCGCTGAAGA AAGGCGGCTG TGACCTGGCC GCTTGCTACG TGAACCCCAG CCAGTTGCCC 
TCGCCTCAGG AGGAGGACGA CCACGATCTC TGTGTGCACT TGGTGCAGCT GCTGCACGGC 
ACGCTGGTGG ATAACATGCA GACCAGACAG GTGGCCGAGA AGTGTCTGGA GCTGGGCATC 
TTCCAGGAGG AGGACCTGGT TGGGATTGAG ACTGTTATTG AGAGTCGTGG GAACAGAGAC 
GGTGCAAGGG AGCTGTTGAG CAGAATAGTG CAGAAGAAGG ACTGGTTCTC TCAGTTTTTG 
GTTGCTCTGC GAGAAACCCA ACATGAAAGC CTTGCAGATG ACTTAAGTGG AAATACAGGA 
GGAACAGAGG ATAAAGACTA TGAGTTGAAG AACAACACAG GCAAAAAAAC AGAAGCTGCA 
AGCCAACCAG TATATGTAAC GGAGGATTTG AAACAGCAAG AAAATTTGGA TGACAGTTTT 
GTCAGAGAGA GCAGTGTATT GGAAACATCT GTTGGAAAGA ACTCTGTAAT TTCAGAATCA 
GTTGCTGTAG GAGATGCAAG TGTCAGTAAC TCGAACGAAA ACCTGGGACA GAGCAGCACG 
ACCAGTGATT CAGGTGAAGA TGAAGCAGAG GGCAGAGCTT CACCTGAGCC AGATCTCACC 
CTGAGAGATT ACCAGATGGA AGTTGCAAAA CCAGCACTGA ATGGGGAGAA TATTATAATA 
TGTCTCCCTA CAGGCAGTGG CAAAACCAGA GTGGCTGTTT ACATTACCAA AGATCACTTG 
GATAAGAAGA GAAAAGCATC AGAGCAAGGA AAAGTTATAG TACTTGTTAA TAAGGTACCG 
TTAGTGGAAC AGCATTTACG AAAGGAGTTT AATCCATTCC TGAAACACTG GTATCAAGTT 
ATTGGCTTAA GTGGTGATTC TGAGCTGAAA ATCTCGTTTC CTGAAGTTGT CAAAAGATAT 
GATGTCATCA TCTGTACAGC ACAGATCCTG GAGAATTCAC TGCTAAATGC AACTGAAGAA 
GATGAAAGTG TCCGCTTGTC AGATTTTTCA CTCATCATTA TTGATGAGTG CCATCACACT 
CAAAAGGAAG GTGTTTACAA CAATATCATG CGACGTTACT TAAAAGAAAA GATCAAGAAC 
AGAAAGCAGG CAAAAGAGAA CAAACCTTTG ATTCCACAGC CGCAGATTCT GGGACTTACA 
GCCTCACCTG GAGTTGGAGG TGCAAGATCC AACTCAAAAG CTGAAGAACA TATTCTGAAA 
ATCTGTGCCA ATCTTGATGC ATGCAGAATC ATGACTGTTA AAGAGCATGC ATCCCAACTG 
AAGAATCAGG TGAAGGAACC ATTTAAGAAG ACTGTGATTG CAGATGACAA AAGAAGGGAT 
CCATTTAGAG AAAGAATTAT TGAGATCATG CAAGATATTC AAAAATATTG CCAGCTCTAT 
CCAAAATCTG AGTTTGGATC TCAGCCATAT GAACAGTGGG TGATTAGGGA AGAGAGAAGA 
GCTGCAAAAG AAGAAAAACG CAAGGAACGT GTCTGTGCAG AACACTTGAA GAAATATAAT 
GATGCTCTGC AAATTAATGA TACCATTCGA ATGGTTGATG CATACAATCA CCTAAATAAC 
TTTTATAAGG AGCTAAAAAG GAGGAAGACA GCGGAGAGTG ATGATGATGA AGAACCATTA 
GTATCAAAAC AGGATGAAAC AGATGAATTT TTAATGCGTT TATTTCATGC AAAAAAGAAA 
CAACTGAAAG AGTTGGCTAG AAAACCAGAA TATGACAATG AGAAGCTAAT GAAGCTCCGG 
AATACTTTAA TGGAAGAGTT CACAAAGACT GAAGAACCTA GAGGGATTAT TTTCACGAAG 
ACTCGACAAA GTGCCTTAGC TTTATACCAC TGGATTATGG ATAATCCAAA ATTTGAAGAA 
GTGGGAATCA AAGCTCATTT TCTTATTGGT GCTGGACACA ATAGTGAAAC TAAACCTATG 
ACTCAGAATG AGCAAAGGGA AGTCATTGAT AAATTCCGAG GTGGAAGTAT AAATTTACTT 
ATTGCTACTA CTGTAGCTGA GGAAGGCCTA GACATCAAAG AGTGTAACAT TGTTATTCGC 
TATGGTCTGG TCACCAATGA AATTGCTATG GTGCAGGCCC GGGGTCGAGC TCGAGCTGAT 
GAGAGCACTT ATGCACTTGT GGCTTCAAGT GGCTCAGGAG CTGTTGAACG TGAAGATGTA 
AATATTTTCC GTGAAAATAT GATGTATAAG GCCATTCGAC GTGTCCAAGA GATGCCGCCA 
GAAGAGTATT TAAATAAGAT TCAGGACTTC CAGTTGCAAA GCATAGTGGA AAAACAAATG 
AAGGCAAAGA GAGATCAGCG TAAGACATAT AAGAAAAACC CTTCACTAAT AACATTCCTG 
TGCAAGAATT GCCACAAGTT GATATGTTCT GGAGAAGATA TACAAGTTAT TGAAAATATG 
CATCATGTCA GTGTGAAAAA AGATTTCCAA CATCTTTACC ATAAAAGAGA AAACAGGACA 
TTGCAAGACA AGCATGCTGA TTACCAGACA AACGTGGAAA TTATATGTAA AGATTGTGGA 
CAAGTTTGGG GAAATATGAT GGTTTATCGA GGTCTTGACC TGCCTTGTCT AAAGATTAGA 
AATTTTGTGG TTGCTTTTGA AGACAAGAAA ACAACAAAGG AAATTTTCAA GAAATGGGGA 
GAACTGCCCA TCATATTTCC TGATTTTGAT TATGCATCTC ATTGTCCTTC AAGTGATGAA 
GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Altered gene expression profiles of the MDA5 signaling pathway in peripheral blood lymphocytes of chickens infected with avian reovirus.
Archives of virology164(10)2451-2458(2019 Oct)
Xie L,Xie Z,Wang S,Huang J,Deng X,Xie Z,Luo S,Zeng T,Zhang Y,Zhang M

Avian infectious bronchitis virus disrupts the melanoma differentiation associated gene 5 (MDA5) signaling pathway by cleavage of the adaptor protein MAVS.
BMC veterinary research13(1)332(2017 Nov)
Yu L,Zhang X,Wu T,Su J,Wang Y,Wang Y,Ruan B,Niu X,Wu Y

MiR-34b-5p Suppresses Melanoma Differentiation-Associated Gene 5 (
Frontiers in cellular and infection microbiology717(2017)
Li Z,Luo Q,Xu H,Zheng M,Abdalla BA,Feng M,Cai B,Zhang X,Nie Q,Zhang X

Promoter structures and differential responses to viral and non-viral inducers of chicken melanoma differentiation-associated gene 5.
Molecular immunology761-6(2016 08)
Zhang WX,Zuo EW,He Y,Chen DY,Long X,Chen MJ,Li TT,Yang XG,Xu HY,Lu SS,Zhang M,Lu KH,Lu YQ

Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
Molecular cell62(4)586-602(2016 05)
Uchikawa E,Lethier M,Malet H,Brunel J,Gerlier D,Cusack S

REQUEST A QUOTE

EMAIL

gene@genscript.com

PHONE

1-877-436-7274

ONLINE FORM

Online Quote Submission

ONLINE FORM

Online Quote Submission

IFIH1 cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

News & Blogs

REQUEST A QUOTE

EMAIL

PHONE

ONLINE FORM

ONLINE FORM