Overview

Anti-idiotype antibodies (anti-ID Abs) are specific to the idiotype (variable region) of another antibody. This feature could be used to measure therapeutic antibody concentration in pre-clinical and clinical studies. An antibody response to the antibody drug might occur and result in devastating consequences in the body. Anti-idiotype antibodies are also commonly used as a reference standard for antibody drug immunogenicity(immune response, IR) studies.

Due to the approvals of the biosimilar products, patients could enjoy an affordable alternative to the innovator drugs. GenScript has generated various types of ready to use anti-idiotype antibodies against blockbuster drugs to support the development of biosimilars. We can also develop custom anti-idiotype antibody service for your new antibody drug development.

Application

Pharmacokinetic (PK) studies: Used to measure the drug level in patient samples

Immunogenicity (anti-drug antibody, ADA) assays: Used as a positive control or reference standard

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