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a Related Biological Terms:

contact site

A small region where the mitochondrial inner and outer membranes touch, and at which structures exist that are responsible for transport of proteins and adenosine nucleotides into and out of the mitochondrion. Moynagh, P.N. (1995) Essays Biochem. 30, 1-14

contact system

The cascade of proteolytic activations of blood factors that is initiated by autoactivation of factor XII when it is adsorbed to a surface, e.g. that of a bacterium, and results in uncontrolled hypotension (shock) due to bradykinin release.Colman, R.W. (1998) Nat. Med. 4, 277-278

contig map

A characterization of a chromosome or large portion of one by contiguous sequences, which are zones of overlap of partially characterized segments; especially used as a strategy for co-ordination of efforts in many laboratories to sequence the human genome. (see also linkage map; physical map; restriction map; sequence-tagged site (STS))

convertase

A cellular proteinase that processes hormone precursors by recognition of the precursor sequence pairs of basic residues, which are the sites of cleavage. Marx, J. (1991) Science 252, 779-780

core glycosylation

The attachment to a protein and modification of N-linked carbohydrate moieties that occurs in the endoplasmic reticulum (see also terminal glycosylation)

correlation spectroscopy (COSY)

A two-dimensional nuclear magnetic resonance technique for detection of connectivity of the resonance of two centres through the covalent bonds that join them. (see also nuclear Overhauser and exchange spectroscopy (NOESY))Kay, L.E. (1995) Curr. Opin. Struct. Biol. 5, 674-681

correlation time

In electron spin resonance and nuclear magnetic resonance spectroscopy, a time constant for the interaction of an observed species with its environment, often related to the rate of decay of its observed property; affected by spin relaxation, rotational motion and chemical exchange.

cosmid walking

A strategy for sequence analysis of a large polynucleotide; chromosome walking using a cosmid.

countercurrent chromatography

A variant of partition chromatography that does not use a solid support to stabilize the stationary phase. A horizontal helical tube is filled with the stationary phase which has been equilibrated with the mobile phase; the mobile phase with solutes to be separated is introduced into one end of the helical tube and fractions are collected from the other. Equilibrium between the phases may be enhanced by slow rotation of the tube around its axis.

countercurrent elutriation

(= centrifugal elutriation)

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