Kdm5b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kdm5b
Entrez Gene ID	304809
Full Name	lysine demethylase 5B
Synonyms	Jarid1b,RGD1565602
General protein information	Preferred Names lysine demethylase 5B Names lysine-specific demethylase 5B Jumonji, AT rich interactive domain 1B (RBP2-like) jumonji, AT rich interactive domain 1B (Rbp2 like) lysine (K)-specific demethylase 5B
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q13

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107177.1	NP_001100647.1	lysine-specific demethylase 5B
XM_008769555.2	XP_008767777.1	lysine-specific demethylase 5B isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	KDM5B	XP_002694248.2
Rattus norvegicus (Norway rat)	Kdm5b	NP_001100647.1
Canis lupus familiaris (dog)	KDM5B	XP_005622266.1
Gallus gallus (chicken)	KDM5B	NP_001026200.1
Danio rerio (zebrafish)	kdm5bb	NP_001002166.1
Xenopus tropicalis (tropical clawed frog)	kdm5b	XP_004910700.1
Mus musculus (house mouse)	Kdm5b	NP_690855.2
Caenorhabditis elegans (roundworm)	rbr-2	NP_502032.2
Pan troglodytes (chimpanzee)	KDM5B	XP_514104.3
Homo sapiens (human)	KDM5B	NP_006609.3
Macaca mulatta (Rhesus monkey)	LOC706437	XP_002808303.1

Gene Ontology
Bibliography

Related articles in PubMed

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.
Tumber A, Nuzzi A, Hookway ES, Hatch SB, Velupillai S, Johansson C, Kawamura A, Savitsky P, Yapp C, Szykowska A, Wu N, Bountra C, Strain-Damerell C, Burgess-Brown NA, Ruda GF, Fedorov O, Munro S, England KS, Nowak RP, Schofield CJ, La Thangue NB, Pawlyn C, Davies F, Morgan G, Athanasou N, Müller S, Oppermann U, Brennan PE
Cell chemical biology24(3)371-380(2017 Mar)

Structural analysis of human KDM5B guides histone demethylase inhibitor development.
Johansson C, Velupillai S, Tumber A, Szykowska A, Hookway ES, Nowak RP, Strain-Damerell C, Gileadi C, Philpott M, Burgess-Brown N, Wu N, Kopec J, Nuzzi A, Steuber H, Egner U, Badock V, Munro S, LaThangue NB, Westaway S, Brown J, Athanasou N, Prinjha R, Brennan PE, Oppermann U
Nature chemical biology12(7)539-45(2016 07)

Overexpressed KDM5B is associated with the progression of glioma and promotes glioma cell growth via downregulating p21.
Dai B, Hu Z, Huang H, Zhu G, Xiao Z, Wan W, Zhang P, Jia W, Zhang L
Biochemical and biophysical research communications454(1)221-7(2014 Nov)

The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B.
Zhang Y, Yang H, Guo X, Rong N, Song Y, Xu Y, Lan W, Zhang X, Liu M, Xu Y, Cao C
Protein & cell5(11)837-50(2014 Nov)

Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes.
Zou MR, Cao J, Liu Z, Huh SJ, Polyak K, Yan Q
The Journal of biological chemistry289(25)17620-33(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Kdm5b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kdm5b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03047	NM_001107177.1 Latest version!	Rattus norvegicus lysine demethylase 5B (Kdm5b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$811.30 $1159.00
ORa46201	XM_008769555.2 Latest version!	Rattus norvegicus lysine demethylase 5B (Kdm5b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$811.30 $1159.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kdm5b ( NM_001107177.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100647.1 Rattus norvegicus lysine demethylase 5B (Kdm5b), mRNA.

Price & Availability↑

CloneID	ORa03047
Clone ID Related Accession (Same CDS sequence)	NM_001107177.1
Accession Version	NM_001107177.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4635bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1532620800000
Organism	Rattus norvegicus(Norway rat)
Product	lysine-specific demethylase 5B
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473958.2. On or before Oct 4, 2007 this sequence version replaced XM_239761.4, XM_001062340.1, XM_001062221.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGAGCCGG CCACCGCGCT GCCCCCAGGC CCGCGCCCGG CGCTGCCCCT TGGGGGCCCC 
GGCCCGCTGG GAGAGTTCCT GCCTCCCCCC GAGTGTCCGG TCTTCGAGCC CAGCTGGGAA 
GAGTTCGCGG ACCCCTTCGC TTTCATCCAC AAGATCCGGC CCATAGCCGA GCAGACTGGG 
ATCTGTAAGG TGCGGCCGCC GCCGGATTGG CAGCCACCAT TCGCTTGTGA TGTTGATAAA 
CTTCATTTTA CCCCGCGTAT CCAGAGGCTT AATGAGCTGG AGGCCCAAAC ACGTGTAAAA 
TTGAACTTCC TGGACCAGAT TGCCAAGTAT TGGGAGCTAC AGGGAAGTAC TCTGAAGATT 
CCTCATGTGG AGAGAAAGAT CTTAGACTTG TTCCAGCTAA ATAAGTTAGT TGCAGAGGAA 
GGTGGGTTTG CAGTTGTTTG CAAGGACAGA AAATGGACCA AAATTGCCAC CAAGATGGGT 
TTTGCTCCTG GTAAAGCAGT GGGCTCACAT ATCAGGGGAC ATTATGAGCG AATCCTCAAT 
CCGTACAATT TGTTCCTATC TGGGGACAGC CTGAGGTGTC TTCAGAAGCC TAACCTGACC 
TCGGACACAA AGGACAAGGA GTACAAACCC CATGATATTC CCCAGAGGCA GTCTGTGCAG 
CCCTCAGAAA CCTGCCCTCC GGCCCGCCGA GCAAAGCGCA TGAGAGCAGA GGCTATGAAT 
ATTAAAATTG AGCCAGAAGA GGCAACAGAA GCCAGGACTC ATAACCTGAG GCGCCGAATG 
GGCTGTGCCA CTCCAAAACG GGAAAACGAG AAAGAAGTGA AAAGTACCAT CAAGCAAGAA 
CCCACCGAGA AGAAAGACTG TGTGTTAGAA AGTGAGAAGG ACAAGCCCAA GAGCCGTGCC 
AAGAAAACCG CCACTGCTGT GGACCTGTAT GTGTGCCTCT TATGTGGCAG CGGCAATGAC 
GAGGACCGGC TGCTCCTGTG TGACGGCTGT GACGACAGTT ACCACACCTT CTGCCTGCTT 
CCCCCTCTCC ATGATGTTCC CAAGGGAGAC TGGAGGTGTC CTAAGTGTTT GGCTCAAGAG 
TGTAGTAAGC CACAAGAAGC TTTCGGCTTT GAACAGGCTG CAAGGGACTA TACACTCCGT 
ACGTTTGGGG AAATGGCAGA TGCATTCAAA TCTGATTACT TCAACATGCC GGTCCATATG 
GTTCCCACAG AGCTGGTGGA GAAGGAGTTT TGGCGGCTGG TAAGCACTAT TGAAGAAGAC 
GTCACCGTGG AGTATGGAGC TGATATTGCT TCAAAAGAGT TTGGCAGTGG CTTTCCTGTT 
CGAGATGGCA AAATCAAGAT TTCTCCTGAG GAAGAGGAGT ATCTTGATAG TGGCTGGAAT 
TTGAATAACA TGCCAGTGAT GGAGCAGTCT GTCCTTGCTC ACATTACTGC TGATATATGC 
GGCATGAAAC TGCCTTGGTT GTATGTGGGC ATGTGCTTTT CTTCCTTCTG TTGGCATATC 
GAAGACCACT GGAGCTATTC AATCAACTAC CTGCACTGGG GTGAGCCGAA AACCTGGTAT 
GGAGTTCCAG GATATGCTGC TGAGCAGCTT GAAAACGTAA TGAAGAAGCT GGCTCCAGAG 
CTCTTTGTGT CCCAGCCAGA CCTCCTCCAC CAGCTTGTGA CGATCATGAA CCCCAATACG 
CTGATGACTC ACGAAGTGCC TGTGTATCGA ACGAATCAGT GTGCTGGGGA GTTTGTCATT 
ACGTTCCCGA GAGCCTACCA CAGTGGCTTC AATCAAGGCT TTAATTTTGC TGAGGCAGTT 
AACTTCTGCA CTGTTGATTG GCTGCCGTTG GGCCGCCAGT GCGTGGAGCA TTATCGCCTG 
CTGCACCGCT ACTGCGTCTT TTCCCATGAT GAGATGATAT GCAAGATGGC TTCCAAGGCT 
GATGTGTTAG ACGTGGTAGT GGCATCCACT GTTCAGAAGG ACATGGCCAT CATGATTGAG 
GATGAAAAGG CTTTAAGGGA AACTGTCCGT AAACTGGGAG TGATTGATTC TGAGAGAATG 
GACTTTGAGC TGTTGCCCGA TGATGAGCGG CAGTGTATAA AGTGCAAAAC TACGTGCTTC 
ATGTCTGCCA TCTCCTGCTC CTGTAAACCT GGCCTGCTTG TTTGCCTGCA TCATGTCAAA 
GAGCTGTGCT CCTGTCCCCC TTACAAGTAT AACCTGCGGT ATAGATACAC TCTGGATGAT 
CTCTATCCGA TGATGAATGC GTTGAAGCTT CGAGCAGAGT CGTACAATGA ATGGGCCTTA 
AATGTGAATG AAGCCTTGGA AGCAAAGATT AATAAGAAGA AAAGTCTCGT CAGCTTTAAA 
GCTTTGATTG AAGAATCAGA AATGAAGAAA TTCCCAGACA ATGATCTTTT GCGTCACCTT 
CGCCTAGTTA CGCAGGATGC AGAAAAGTGT GCCTCTGTTG CCCAGCAGTT GCTTAATGGC 
AAAAGGCAAA CGAGGTATCG ATCTGGTGGA GGGAAGTCTC AGAGTCAGCT GACAGTGAAT 
GAGCTTCGGC AGTTCGTGAC TCAGCTGTGC GCTCTTCCCT GCGTCCTTAG TCAGACACCA 
CTGCTAAAGG ATCTCTTGAA TCGTGTGGAA GATTTCCAGC AGCAAAGCCA GAGACTGCTG 
TCTGAGGAGA GGCCCCGTGC TTCTGAGCTT CAGCAGTTGC TGGATGTCAG CTTCACTTTT 
GATGTTGAAC TTCCACAGCT AGCTGAGATG CGTATCCGCT TAGAACAGGC CCGTTGGCTA 
GAAGAGGTTC AGCAGGCTTG CCTGGACTCC AGCTCCCTTT CTTTGGATGA TATGAGACGA 
CTCATAGACT TAGGGGTGGG GCTAGCTCCA TATTCTGCCG TGGAGAAAGC TATGGCCCGC 
CTGCAGGAAC TGCTAACAGT GTCAGAGCAC TGGGACGACA AAGCCAAGAG TCTCCTCAGA 
GCAAGACCTC GGCATTCCTT GAGTAGCCTT GCTACAGCAG TAAAAGAGAT GGAGGAGATC 
CCCGCCTATC TGCCCAATGG TACAGTCCTG AAGGATTCTG TGCAGAAAGC CAGAGACTGG 
GTTCAGGATG TAGATGCATT GCAGGCAGGA GGACGCGTGC CAGTGTTAGA AACACTCATT 
GAACTTGTCG CAAGAGGCCG ATCCATCCCG GTACATCTGA ATTCTTTACC CAGATTGGAA 
ATGCTAGTAT CCGAGGTTCA TGCTTGGAAA GAAAGCGCTG CTAAAACATT CCTGCTTGAG 
AATTCGCCAT ACTCTCTGTT AGAGGTTCTT TGTCCTCGGT GTGACATTGG CCTTTTGGGA 
TTGAAAAGGA AGCAGAGAAA GTTGAAGGAT CCCTTGCCAA GTGGGAAGAA GAGAAGCACC 
AAGTTAGAGA GTCTGAGTGA TCTGGAAAGG GCTCTGACTG AGAGCAAAGA GACGGCGTCA 
GCTATGGCAA CTCTTGGGGA AGCTCGCCTA CGAGAGATGG AAGCTTTGCA GTCTCTCAGA 
TTTGCCAATG AAGAGAAATT GCTGTCACCT GCCCAAGATG TGGAGACGAA GGTTTGCTTG 
TGTCAGAAGA CTCCAGCCAC TCCCATGATT CAGTGTGAAC TCTGCAGGGA TGCTTTCCAT 
ACTAGTTGTG TGGCGGTGTC CAGTATTTCA CAAAGCTCCC GAATCTGGCT TTGTCCTCAC 
TGTCGAAGGT CAGAGAAGCC TCCATTAGAG AAAATTCTGC CTCTGCTGGC CTCCCTACAG 
CGTATAAGAG TTCGTCTTCC TGAAGGGGAT GCACTCCGAT ACATGATTGA AAGAACCGTG 
AACTGGCAAC ATAGAGCCCA GCAACTGCTT TCTTCAGGGA ATCTAAAACT TGTGCAGGAC 
CAAGCGGGTT CTGGACTGTT GTTTAGCAGA TGGCCAGCCT CAGCAGGAAC GGCGTCAGCA 
GCAGACAAGG TGTCTCAACC TCCTGGCACA ACATCCTTTT CATTGCCGGA AGACTGGGAC 
AACAGAACCT CATATTTACA CTCTCCCTTC TCTACCGGTC AGAGTTGTAT CCCCCTTCAT 
GGTTTGAGTC CAGAGGTGAA TGAATTGCTG ATGGAAGCCC AGTTGCTCCA GGTGTCCCTC 
CCTGAAGTCC AGGAGCTTTA TCAGACTTTA CTTACGAAGC CAAGCTCTGC TCAGCAAGCC 
GACCGAAGCT CACCAGTCAG ACCCAGCAGT GAGAAGAACG ATTGTCTTCG AGGGAAACGA 
GATGCAATCA ACAGTCTTGA GAGAAAACTG AAAAGACGCC CAGAAAGAGA AGGCCTTCCC 
AGTGAACGGT GGGATCGAGT TAAAAAAATG CGGACCCCTC AAAAGAAGAA AATCAAACTG 
AGTCACCCCA AGGACATGAA CAATTTCAAA TTAGAAAGAG AGCGTAGCTA TGACTTAGTC 
CGGAATGCTG AAACTCATTC CCTGCCCTCA GACACATCCT ACTCCGAGCA GGAGGACTCT 
GAGGATGAAG ATGCCATCTG TCCAGCTGTG AGCTGCCTGC AGCCAGAAGG AGATGAGGTG 
GACTGGGTCC AGTGTGATGG CAGCTGCAAT CAGTGGTTTC ATCAGGTCTG TGTTGGTGTC 
TCTCCAGAGA TGGCAGAGAA AGAAGACTAC ATCTGTGTGC GCTGTACTGG AAAGGACGCA 
CCAAGCCGAA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100647.1
CDS	167..4801
Translation	MEPATALPPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRCLQKPNLTSDTKDKEYKPHDIPQRQSVQPSETCPPARRAKRMRAEAMNIKIEPEEATEARTHNLRRRMGCATPKRENEKEVKSTIKQEPTEKKDCVLESEKDKPKSRAKKTATAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLLPPLHDVPKGDWRCPKCLAQECSKPQEAFGFEQAARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGKIKISPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCIKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYNLRYRYTLDDLYPMMNALKLRAESYNEWALNVNEALEAKINKKKSLVSFKALIEESEMKKFPDNDLLRHLRLVTQDAEKCASVAQQLLNGKRQTRYRSGGGKSQSQLTVNELRQFVTQLCALPCVLSQTPLLKDLLNRVEDFQQQSQRLLSEERPRASELQQLLDVSFTFDVELPQLAEMRIRLEQARWLEEVQQACLDSSSLSLDDMRRLIDLGVGLAPYSAVEKAMARLQELLTVSEHWDDKAKSLLRARPRHSLSSLATAVKEMEEIPAYLPNGTVLKDSVQKARDWVQDVDALQAGGRVPVLETLIELVARGRSIPVHLNSLPRLEMLVSEVHAWKESAAKTFLLENSPYSLLEVLCPRCDIGLLGLKRKQRKLKDPLPSGKKRSTKLESLSDLERALTESKETASAMATLGEARLREMEALQSLRFANEEKLLSPAQDVETKVCLCQKTPATPMIQCELCRDAFHTSCVAVSSISQSSRIWLCPHCRRSEKPPLEKILPLLASLQRIRVRLPEGDALRYMIERTVNWQHRAQQLLSSGNLKLVQDQAGSGLLFSRWPASAGTASAADKVSQPPGTTSFSLPEDWDNRTSYLHSPFSTGQSCIPLHGLSPEVNELLMEAQLLQVSLPEVQELYQTLLTKPSSAQQADRSSPVRPSSEKNDCLRGKRDAINSLERKLKRRPEREGLPSERWDRVKKMRTPQKKKIKLSHPKDMNNFKLERERSYDLVRNAETHSLPSDTSYSEQEDSEDEDAICPAVSCLQPEGDEVDWVQCDGSCNQWFHQVCVGVSPEMAEKEDYICVRCTGKDAPSRK

Target ORF information:

RefSeq Version	NM_001107177.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lysine demethylase 5B (Kdm5b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107177.1

ORF Insert Sequence:

ATGGAGCCGG CCACCGCGCT GCCCCCAGGC CCGCGCCCGG CGCTGCCCCT TGGGGGCCCC 
GGCCCGCTGG GAGAGTTCCT GCCTCCCCCC GAGTGTCCGG TCTTCGAGCC CAGCTGGGAA 
GAGTTCGCGG ACCCCTTCGC TTTCATCCAC AAGATCCGGC CCATAGCCGA GCAGACTGGG 
ATCTGTAAGG TGCGGCCGCC GCCGGATTGG CAGCCACCAT TCGCTTGTGA TGTTGATAAA 
CTTCATTTTA CCCCGCGTAT CCAGAGGCTT AATGAGCTGG AGGCCCAAAC ACGTGTAAAA 
TTGAACTTCC TGGACCAGAT TGCCAAGTAT TGGGAGCTAC AGGGAAGTAC TCTGAAGATT 
CCTCATGTGG AGAGAAAGAT CTTAGACTTG TTCCAGCTAA ATAAGTTAGT TGCAGAGGAA 
GGTGGGTTTG CAGTTGTTTG CAAGGACAGA AAATGGACCA AAATTGCCAC CAAGATGGGT 
TTTGCTCCTG GTAAAGCAGT GGGCTCACAT ATCAGGGGAC ATTATGAGCG AATCCTCAAT 
CCGTACAATT TGTTCCTATC TGGGGACAGC CTGAGGTGTC TTCAGAAGCC TAACCTGACC 
TCGGACACAA AGGACAAGGA GTACAAACCC CATGATATTC CCCAGAGGCA GTCTGTGCAG 
CCCTCAGAAA CCTGCCCTCC GGCCCGCCGA GCAAAGCGCA TGAGAGCAGA GGCTATGAAT 
ATTAAAATTG AGCCAGAAGA GGCAACAGAA GCCAGGACTC ATAACCTGAG GCGCCGAATG 
GGCTGTGCCA CTCCAAAACG GGAAAACGAG AAAGAAGTGA AAAGTACCAT CAAGCAAGAA 
CCCACCGAGA AGAAAGACTG TGTGTTAGAA AGTGAGAAGG ACAAGCCCAA GAGCCGTGCC 
AAGAAAACCG CCACTGCTGT GGACCTGTAT GTGTGCCTCT TATGTGGCAG CGGCAATGAC 
GAGGACCGGC TGCTCCTGTG TGACGGCTGT GACGACAGTT ACCACACCTT CTGCCTGCTT 
CCCCCTCTCC ATGATGTTCC CAAGGGAGAC TGGAGGTGTC CTAAGTGTTT GGCTCAAGAG 
TGTAGTAAGC CACAAGAAGC TTTCGGCTTT GAACAGGCTG CAAGGGACTA TACACTCCGT 
ACGTTTGGGG AAATGGCAGA TGCATTCAAA TCTGATTACT TCAACATGCC GGTCCATATG 
GTTCCCACAG AGCTGGTGGA GAAGGAGTTT TGGCGGCTGG TAAGCACTAT TGAAGAAGAC 
GTCACCGTGG AGTATGGAGC TGATATTGCT TCAAAAGAGT TTGGCAGTGG CTTTCCTGTT 
CGAGATGGCA AAATCAAGAT TTCTCCTGAG GAAGAGGAGT ATCTTGATAG TGGCTGGAAT 
TTGAATAACA TGCCAGTGAT GGAGCAGTCT GTCCTTGCTC ACATTACTGC TGATATATGC 
GGCATGAAAC TGCCTTGGTT GTATGTGGGC ATGTGCTTTT CTTCCTTCTG TTGGCATATC 
GAAGACCACT GGAGCTATTC AATCAACTAC CTGCACTGGG GTGAGCCGAA AACCTGGTAT 
GGAGTTCCAG GATATGCTGC TGAGCAGCTT GAAAACGTAA TGAAGAAGCT GGCTCCAGAG 
CTCTTTGTGT CCCAGCCAGA CCTCCTCCAC CAGCTTGTGA CGATCATGAA CCCCAATACG 
CTGATGACTC ACGAAGTGCC TGTGTATCGA ACGAATCAGT GTGCTGGGGA GTTTGTCATT 
ACGTTCCCGA GAGCCTACCA CAGTGGCTTC AATCAAGGCT TTAATTTTGC TGAGGCAGTT 
AACTTCTGCA CTGTTGATTG GCTGCCGTTG GGCCGCCAGT GCGTGGAGCA TTATCGCCTG 
CTGCACCGCT ACTGCGTCTT TTCCCATGAT GAGATGATAT GCAAGATGGC TTCCAAGGCT 
GATGTGTTAG ACGTGGTAGT GGCATCCACT GTTCAGAAGG ACATGGCCAT CATGATTGAG 
GATGAAAAGG CTTTAAGGGA AACTGTCCGT AAACTGGGAG TGATTGATTC TGAGAGAATG 
GACTTTGAGC TGTTGCCCGA TGATGAGCGG CAGTGTATAA AGTGCAAAAC TACGTGCTTC 
ATGTCTGCCA TCTCCTGCTC CTGTAAACCT GGCCTGCTTG TTTGCCTGCA TCATGTCAAA 
GAGCTGTGCT CCTGTCCCCC TTACAAGTAT AACCTGCGGT ATAGATACAC TCTGGATGAT 
CTCTATCCGA TGATGAATGC GTTGAAGCTT CGAGCAGAGT CGTACAATGA ATGGGCCTTA 
AATGTGAATG AAGCCTTGGA AGCAAAGATT AATAAGAAGA AAAGTCTCGT CAGCTTTAAA 
GCTTTGATTG AAGAATCAGA AATGAAGAAA TTCCCAGACA ATGATCTTTT GCGTCACCTT 
CGCCTAGTTA CGCAGGATGC AGAAAAGTGT GCCTCTGTTG CCCAGCAGTT GCTTAATGGC 
AAAAGGCAAA CGAGGTATCG ATCTGGTGGA GGGAAGTCTC AGAGTCAGCT GACAGTGAAT 
GAGCTTCGGC AGTTCGTGAC TCAGCTGTGC GCTCTTCCCT GCGTCCTTAG TCAGACACCA 
CTGCTAAAGG ATCTCTTGAA TCGTGTGGAA GATTTCCAGC AGCAAAGCCA GAGACTGCTG 
TCTGAGGAGA GGCCCCGTGC TTCTGAGCTT CAGCAGTTGC TGGATGTCAG CTTCACTTTT 
GATGTTGAAC TTCCACAGCT AGCTGAGATG CGTATCCGCT TAGAACAGGC CCGTTGGCTA 
GAAGAGGTTC AGCAGGCTTG CCTGGACTCC AGCTCCCTTT CTTTGGATGA TATGAGACGA 
CTCATAGACT TAGGGGTGGG GCTAGCTCCA TATTCTGCCG TGGAGAAAGC TATGGCCCGC 
CTGCAGGAAC TGCTAACAGT GTCAGAGCAC TGGGACGACA AAGCCAAGAG TCTCCTCAGA 
GCAAGACCTC GGCATTCCTT GAGTAGCCTT GCTACAGCAG TAAAAGAGAT GGAGGAGATC 
CCCGCCTATC TGCCCAATGG TACAGTCCTG AAGGATTCTG TGCAGAAAGC CAGAGACTGG 
GTTCAGGATG TAGATGCATT GCAGGCAGGA GGACGCGTGC CAGTGTTAGA AACACTCATT 
GAACTTGTCG CAAGAGGCCG ATCCATCCCG GTACATCTGA ATTCTTTACC CAGATTGGAA 
ATGCTAGTAT CCGAGGTTCA TGCTTGGAAA GAAAGCGCTG CTAAAACATT CCTGCTTGAG 
AATTCGCCAT ACTCTCTGTT AGAGGTTCTT TGTCCTCGGT GTGACATTGG CCTTTTGGGA 
TTGAAAAGGA AGCAGAGAAA GTTGAAGGAT CCCTTGCCAA GTGGGAAGAA GAGAAGCACC 
AAGTTAGAGA GTCTGAGTGA TCTGGAAAGG GCTCTGACTG AGAGCAAAGA GACGGCGTCA 
GCTATGGCAA CTCTTGGGGA AGCTCGCCTA CGAGAGATGG AAGCTTTGCA GTCTCTCAGA 
TTTGCCAATG AAGAGAAATT GCTGTCACCT GCCCAAGATG TGGAGACGAA GGTTTGCTTG 
TGTCAGAAGA CTCCAGCCAC TCCCATGATT CAGTGTGAAC TCTGCAGGGA TGCTTTCCAT 
ACTAGTTGTG TGGCGGTGTC CAGTATTTCA CAAAGCTCCC GAATCTGGCT TTGTCCTCAC 
TGTCGAAGGT CAGAGAAGCC TCCATTAGAG AAAATTCTGC CTCTGCTGGC CTCCCTACAG 
CGTATAAGAG TTCGTCTTCC TGAAGGGGAT GCACTCCGAT ACATGATTGA AAGAACCGTG 
AACTGGCAAC ATAGAGCCCA GCAACTGCTT TCTTCAGGGA ATCTAAAACT TGTGCAGGAC 
CAAGCGGGTT CTGGACTGTT GTTTAGCAGA TGGCCAGCCT CAGCAGGAAC GGCGTCAGCA 
GCAGACAAGG TGTCTCAACC TCCTGGCACA ACATCCTTTT CATTGCCGGA AGACTGGGAC 
AACAGAACCT CATATTTACA CTCTCCCTTC TCTACCGGTC AGAGTTGTAT CCCCCTTCAT 
GGTTTGAGTC CAGAGGTGAA TGAATTGCTG ATGGAAGCCC AGTTGCTCCA GGTGTCCCTC 
CCTGAAGTCC AGGAGCTTTA TCAGACTTTA CTTACGAAGC CAAGCTCTGC TCAGCAAGCC 
GACCGAAGCT CACCAGTCAG ACCCAGCAGT GAGAAGAACG ATTGTCTTCG AGGGAAACGA 
GATGCAATCA ACAGTCTTGA GAGAAAACTG AAAAGACGCC CAGAAAGAGA AGGCCTTCCC 
AGTGAACGGT GGGATCGAGT TAAAAAAATG CGGACCCCTC AAAAGAAGAA AATCAAACTG 
AGTCACCCCA AGGACATGAA CAATTTCAAA TTAGAAAGAG AGCGTAGCTA TGACTTAGTC 
CGGAATGCTG AAACTCATTC CCTGCCCTCA GACACATCCT ACTCCGAGCA GGAGGACTCT 
GAGGATGAAG ATGCCATCTG TCCAGCTGTG AGCTGCCTGC AGCCAGAAGG AGATGAGGTG 
GACTGGGTCC AGTGTGATGG CAGCTGCAAT CAGTGGTTTC ATCAGGTCTG TGTTGGTGTC 
TCTCCAGAGA TGGCAGAGAA AGAAGACTAC ATCTGTGTGC GCTGTACTGG AAAGGACGCA 
CCAAGCCGAA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kdm5b ( XM_008769555.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008767777.1 Rattus norvegicus lysine demethylase 5B (Kdm5b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa46201
Clone ID Related Accession (Same CDS sequence)	XM_008769555.2
Accession Version	XM_008769555.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4617bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	lysine-specific demethylase 5B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008769555.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 1% of CDS bases ##RefSeq-Attributes-END##

ATGGAGCCGG CCACCGCGCT GCCCCCAGGC CCGCGCCCGG CGCTGCCCCT TGGGGGCCCC 
GGCCCGCTGG GAGAGTTCCT GCCTCCCCCC GAGTGTCCGG TCTTCGAGCC CAGCTGGGAA 
GAGTTCGCGG ACCCCTTCGC TTTCATCCAC AAGATCCGGC CCATAGCCGA GCAGACTGGG 
ATCTGTAAGG TGCGGCCGCC GCCGGATTGG CAGCCACCAT TCGCTTGTGA TGTTGATAAA 
CTTCATTTTA CCCCGCGTAT CCAGAGGCTT AATGAGCTGG AGGCCCAAAC ACGTGTAAAA 
TTGAACTTCC TGGACCAGAT TGCCAAGTAT TGGGAGCTAC AGGGAAGTAC TCTGAAGATT 
CCTCATGTGG AGAGAAAGAT CTTAGACTTG TTCCAGCTAA ATAAGTTAGT TGCAGAGGAA 
GGTGGGTTTG CAGTTGTTTG CAAGGACAGA AAATGGACCA AAATTGCCAC CAAGATGGGT 
TTTGCTCCTG GTAAAGCAGT GGGCTCACAT ATCAGGGGAC ATTATGAGCG AATCCTCAAT 
CCGTACAATT TGTTCCTATC TGGGGACAGC CTGAGGTGTC TTCAGAAGCC TAACCTGACC 
TCGGACACAA AGGACAAGGA GTACAAACCC CATGATATTC CCCAGAGGCA GTCTGTGCAG 
CCCTCAGAAA CCTGCCCTCC GGCCCGCCGA GCAAAGCGCA TGAGAGCAGA GGCTATGAAT 
ATTAAAATTG AGCCAGAAGA GGCAACAGAA GCCAGGACTC ATAACCTGAG GCGCCGAATG 
GGCTGTGCCA CTCCAAAACG GGAAAACGAG AAAGAAGTGA AAAGTACCAT CAAGCAAGAA 
CCCACCGAGA AGAAAGACTG TGTGTTAGAA AGTGAGAAGG ACAAGGACAA GCCCAAGAGC 
CGTGCCAAGA AAACCGCCAC TGCTGTGGAC CTGTATGTGT GCCTCTTATG TGGCAGCGGC 
AATGACGAGG ACCGGCTGCT CCTGTGTGAC GGCTGTGACG ACAGTTACCA CACCTTCTGC 
CTGCTTCCCC CTCTCCATGA TGTTCCCAAG GGAGACTGGA GGTGTCCTAA GTGTTTGGCT 
CAAGAGTGTA GTAAGCCACA AGAAGCTTTC GGCTTTGAAC AGGCTGCAAG GGACTATACA 
CTCCGTACGT TTGGGGAAAT GGCAGATGCA TTCAAATCTG ATTACTTCAA CATGCCGGTC 
CATATGGTTC CCACAGAGCT GGTGGAGAAG GAGTTTTGGC GGCTGGTAAG CACTATTGAA 
GAAGACGTCA CCGTGGAGTA TGGAGCTGAT ATTGCTTCAA AAGAGTTTGG CAGTGGCTTT 
CCTGTTCGAG ATGGCAAAAT CAAGATTTCT CCTGAGGAAG AGGAGTATCT TGATAGTGGC 
TGGAATTTGA ATAACATGCC AGTGATGGAG CAGTCTGTCC TTGCTCACAT TACTGCTGAT 
ATATGCGGCA TGAAACTGCC TTGGTTGTAT GTGGGCATGT GCTTTTCTTC CTTCTGTTGG 
CATATCGAAG ACCACTGGAG CTATTCAATC AACTACCTGC ACTGGGGTGA GCCGAAAACC 
TGGTATGGAG TTCCAGGATA TGCTGCTGAG CAGCTTGAAA ACGTAATGAA GAAGCTGGCT 
CCAGAGCTCT TTGTGTCCCA GCCAGACCTC CTCCACCAGC TTGTGACGAT CATGAACCCC 
AATACGCTGA TGACTCACGA AGTGCCTGTG TATCGAACGA ATCAGTGTGC TGGGGAGTTT 
GTCATTACGT TCCCGAGAGC CTACCACAGT GGCTTCAATC AAGGCTTTAA TTTTGCTGAG 
GCAGTTAACT TCTGCACTGT TGATTGGCTG CCGTTGGGCC GCCAGTGCGT GGAGCATTAT 
CGCCTGCTGC ACCGCTACTG CGTCTTTTCC CATGATGAGA TGATATGCAA GATGGCTTCC 
AAGGCTGATG TGTTAGACGT GGTAGTGGCA TCCACTGTTC AGAAGGACAT GGCCATCATG 
ATTGAGGATG AAAAGGCTTT AAGGGAAACT GTCCGTAAAC TGGGAGTGAT TGATTCTGAG 
AGAATGGACT TTGAGCTGTT GCCCGATGAT GAGCGGCAGT GTATAAAGTG CAAAACTACG 
TGCTTCATGT CTGCCATCTC CTGCTCCTGT AAACCTGGCC TGCTTGTTTG CCTGCATCAT 
GTCAAAGAGC TGTGCTCCTG TCCCCCTTAC AAGTATAACC TGCGGTATAG ATACACTCTG 
GATGATCTCT ATCCGATGAT GAATGCGTTG AAGCTTCGAG CAGAGTCGTA CAATGAATGG 
GCCTTAAATG TGAATGAAGC CTTGGAAGCA AAGATTAATA AGAAGAAAAG TCTCGTCAGC 
TTTAAAGCTT TGATTGAAGA ATCAGAAATG AAGAAATTCC CAGACAATGA TCTTTTGCGT 
CACCTTCGCC TAGTTACGCA GGATGCAGAA AAGTGTGCCT CTGTTGCCCA GCAGTTGCTT 
AATGGCAAAA GGCAAACGAG GTATCGATCT GGTGGAGGGA AGTCTCAGAG TCAGCTGACA 
GTGAATGAGC TTCGGCAGTT CGTGACTCAG CTGTGCGCTC TTCCCTGCGT CCTTAGTCAG 
ACACCACTGC TAAAGGATCT CTTGAATCGT GTGGAAGATT TCCAGCAGCA AAGCCAGAGA 
CTGCTGTCTG AGGAGAGGCC CCGTGCTTCT GAGCTTCAGC AGTTGCTGGA TGTCAGCTTC 
ACTTTTGATG TTGAACTTCC ACAGCTAGCT GAGATGCGTA TCCGCTTAGA ACAGGCCCGT 
TGGCTAGAAG AGGTTCAGCA GGCTTGCCTG GACTCCAGCT CCCTTTCTTT GGATGATATG 
AGACGACTCA TAGACTTAGG GGTGGGGCTA GCTCCATATT CTGCCGTGGA GAAAGCTATG 
GCCCGCCTGC AGGAACTGCT AACAGTGTCA GAGCACTGGG ACGACAAAGC CAAGAGTCTC 
CTCAGAGCAA GACCTCGGCA TTCCTTGAGT AGCCTTGCTA CAGCAGTAAA AGAGATGGAG 
GAGATCCCCG CCTATCTGCC CAATGGTACA GTCCTGAAGG ATTCTGTGCA GAAAGCCAGA 
GACTGGGTTC AGGATGTAGA TGCATTGCAG GCAGGAGGAC GCGTGCCAGT GTTAGAAACA 
CTCATTGAAC TTGTCGCAAG AGGCCGATCC ATCCCGGTAC ATCTGAATTC TTTACCCAGA 
TTGGAAATGC TAGTATCCGA GGTTCATGCT TGGAAAGAAA GCGCTGCTAA AACATTCCTG 
CTTGAGAATT CGCCATACTC TCTGTTAGAG GTAAGTTTGC AGTGGAAAAG GAAGCAGAGA 
AAGTTGAAGG ATCCCTTGCC AAGTGGGAAG AAGAGAAGCA CCAAGTTAGA GAGTCTGAGT 
GATCTGGAAA GGGCTCTGAC TGAGAGCAAA GAGACGGCGT CAGCTATGGC AACTCTTGGG 
GAAGCTCGCC TACGAGAGAT GGAAGCTTTG CAGTCTCTCA GATTTGCCAA TGAAGAGAAA 
TTGCTGTCAC CTGCCCAAGA TGTGGAGACG AAGGTTTGCT TGTGTCAGAA GACTCCAGCC 
ACTCCCATGA TTCAGTGTGA ACTCTGCAGG GATGCTTTCC ATACTAGTTG TGTGGCGGTG 
TCCAGTATTT CACAAAGCTC CCGAATCTGG CTTTGTCCTC ACTGTCGAAG GTCAGAGAAG 
CCTCCATTAG AGAAAATTCT GCCTCTGCTG GCCTCCCTAC AGCGTATAAG AGTTCGTCTT 
CCTGAAGGGG ATGCACTCCG ATACATGATT GAAAGAACCG TGAACTGGCA ACATAGAGCC 
CAGCAACTGC TTTCTTCAGG GAATCTAAAA CTTGTGCAGG ACCAAGCGGG TTCTGGACTG 
TTGTTTAGCA GATGGCCAGC CTCAGCAGGA ACGGCGTCAG CAGCAGACAA GGTGTCTCAA 
CCTCCTGGCA CAACATCCTT TTCATTGCCG GAAGACTGGG ACAACAGAAC CTCATATTTA 
CACTCTCCCT TCTCTACCGG TCAGAGTTGT ATCCCCCTTC ATGGTTTGAG TCCAGAGGTG 
AATGAATTGC TGATGGAAGC CCAGTTGCTC CAGGTGTCCC TCCCTGAAGT CCAGGAGCTT 
TATCAGACTT TACTTACGAA GCCAAGCTCT GCTCAGCAAG CCGACCGAAG CTCACCAGTC 
AGACCCAGCA GTGAGAAGAA CGATTGTCTT CGAGGGAAAC GAGATGCAAT CAACAGTCTT 
GAGAGAAAAC TGAAAAGACG CCCAGAAAGA GAAGGCCTTC CCAGTGAACG GTGGGATCGA 
GTTAAAAAAA TGCGGACCCC TCAAAAGAAG AAAATCAAAC TGAGTCACCC CAAGGACATG 
AACAATTTCA AATTAGAAAG AGAGCGTAGC TATGACTTAG TCCGGAATGC TGAAACTCAT 
TCCCTGCCCT CAGACACATC CTACTCCGAG CAGGAGGACT CTGAGGATGA AGATGCCATC 
TGTCCAGCTG TGAGCTGCCT GCAGCCAGAA GGAGATGAGG TGGACTGGGT CCAGTGTGAT 
GGCAGCTGCA ATCAGTGGTT TCATCAGGTC TGTGTTGGTG TCTCTCCAGA GATGGCAGAG 
AAAGAAGACT ACATCTGTGT GCGCTGTACT GGAAAGGACG CACCAAGCCG AAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008767777.1
CDS	192..4808
Translation	MEPATALPPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRCLQKPNLTSDTKDKEYKPHDIPQRQSVQPSETCPPARRAKRMRAEAMNIKIEPEEATEARTHNLRRRMGCATPKRENEKEVKSTIKQEPTEKKDCVLESEKDKDKPKSRAKKTATAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLLPPLHDVPKGDWRCPKCLAQECSKPQEAFGFEQAARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGKIKISPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCIKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYNLRYRYTLDDLYPMMNALKLRAESYNEWALNVNEALEAKINKKKSLVSFKALIEESEMKKFPDNDLLRHLRLVTQDAEKCASVAQQLLNGKRQTRYRSGGGKSQSQLTVNELRQFVTQLCALPCVLSQTPLLKDLLNRVEDFQQQSQRLLSEERPRASELQQLLDVSFTFDVELPQLAEMRIRLEQARWLEEVQQACLDSSSLSLDDMRRLIDLGVGLAPYSAVEKAMARLQELLTVSEHWDDKAKSLLRARPRHSLSSLATAVKEMEEIPAYLPNGTVLKDSVQKARDWVQDVDALQAGGRVPVLETLIELVARGRSIPVHLNSLPRLEMLVSEVHAWKESAAKTFLLENSPYSLLEVSLQWKRKQRKLKDPLPSGKKRSTKLESLSDLERALTESKETASAMATLGEARLREMEALQSLRFANEEKLLSPAQDVETKVCLCQKTPATPMIQCELCRDAFHTSCVAVSSISQSSRIWLCPHCRRSEKPPLEKILPLLASLQRIRVRLPEGDALRYMIERTVNWQHRAQQLLSSGNLKLVQDQAGSGLLFSRWPASAGTASAADKVSQPPGTTSFSLPEDWDNRTSYLHSPFSTGQSCIPLHGLSPEVNELLMEAQLLQVSLPEVQELYQTLLTKPSSAQQADRSSPVRPSSEKNDCLRGKRDAINSLERKLKRRPEREGLPSERWDRVKKMRTPQKKKIKLSHPKDMNNFKLERERSYDLVRNAETHSLPSDTSYSEQEDSEDEDAICPAVSCLQPEGDEVDWVQCDGSCNQWFHQVCVGVSPEMAEKEDYICVRCTGKDAPSRK

Target ORF information:

RefSeq Version	XM_008769555.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lysine demethylase 5B (Kdm5b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008769555.2

ORF Insert Sequence:

ATGGAGCCGG CCACCGCGCT GCCCCCAGGC CCGCGCCCGG CGCTGCCCCT TGGGGGCCCC 
GGCCCGCTGG GAGAGTTCCT GCCTCCCCCC GAGTGTCCGG TCTTCGAGCC CAGCTGGGAA 
GAGTTCGCGG ACCCCTTCGC TTTCATCCAC AAGATCCGGC CCATAGCCGA GCAGACTGGG 
ATCTGTAAGG TGCGGCCGCC GCCGGATTGG CAGCCACCAT TCGCTTGTGA TGTTGATAAA 
CTTCATTTTA CCCCGCGTAT CCAGAGGCTT AATGAGCTGG AGGCCCAAAC ACGTGTAAAA 
TTGAACTTCC TGGACCAGAT TGCCAAGTAT TGGGAGCTAC AGGGAAGTAC TCTGAAGATT 
CCTCATGTGG AGAGAAAGAT CTTAGACTTG TTCCAGCTAA ATAAGTTAGT TGCAGAGGAA 
GGTGGGTTTG CAGTTGTTTG CAAGGACAGA AAATGGACCA AAATTGCCAC CAAGATGGGT 
TTTGCTCCTG GTAAAGCAGT GGGCTCACAT ATCAGGGGAC ATTATGAGCG AATCCTCAAT 
CCGTACAATT TGTTCCTATC TGGGGACAGC CTGAGGTGTC TTCAGAAGCC TAACCTGACC 
TCGGACACAA AGGACAAGGA GTACAAACCC CATGATATTC CCCAGAGGCA GTCTGTGCAG 
CCCTCAGAAA CCTGCCCTCC GGCCCGCCGA GCAAAGCGCA TGAGAGCAGA GGCTATGAAT 
ATTAAAATTG AGCCAGAAGA GGCAACAGAA GCCAGGACTC ATAACCTGAG GCGCCGAATG 
GGCTGTGCCA CTCCAAAACG GGAAAACGAG AAAGAAGTGA AAAGTACCAT CAAGCAAGAA 
CCCACCGAGA AGAAAGACTG TGTGTTAGAA AGTGAGAAGG ACAAGGACAA GCCCAAGAGC 
CGTGCCAAGA AAACCGCCAC TGCTGTGGAC CTGTATGTGT GCCTCTTATG TGGCAGCGGC 
AATGACGAGG ACCGGCTGCT CCTGTGTGAC GGCTGTGACG ACAGTTACCA CACCTTCTGC 
CTGCTTCCCC CTCTCCATGA TGTTCCCAAG GGAGACTGGA GGTGTCCTAA GTGTTTGGCT 
CAAGAGTGTA GTAAGCCACA AGAAGCTTTC GGCTTTGAAC AGGCTGCAAG GGACTATACA 
CTCCGTACGT TTGGGGAAAT GGCAGATGCA TTCAAATCTG ATTACTTCAA CATGCCGGTC 
CATATGGTTC CCACAGAGCT GGTGGAGAAG GAGTTTTGGC GGCTGGTAAG CACTATTGAA 
GAAGACGTCA CCGTGGAGTA TGGAGCTGAT ATTGCTTCAA AAGAGTTTGG CAGTGGCTTT 
CCTGTTCGAG ATGGCAAAAT CAAGATTTCT CCTGAGGAAG AGGAGTATCT TGATAGTGGC 
TGGAATTTGA ATAACATGCC AGTGATGGAG CAGTCTGTCC TTGCTCACAT TACTGCTGAT 
ATATGCGGCA TGAAACTGCC TTGGTTGTAT GTGGGCATGT GCTTTTCTTC CTTCTGTTGG 
CATATCGAAG ACCACTGGAG CTATTCAATC AACTACCTGC ACTGGGGTGA GCCGAAAACC 
TGGTATGGAG TTCCAGGATA TGCTGCTGAG CAGCTTGAAA ACGTAATGAA GAAGCTGGCT 
CCAGAGCTCT TTGTGTCCCA GCCAGACCTC CTCCACCAGC TTGTGACGAT CATGAACCCC 
AATACGCTGA TGACTCACGA AGTGCCTGTG TATCGAACGA ATCAGTGTGC TGGGGAGTTT 
GTCATTACGT TCCCGAGAGC CTACCACAGT GGCTTCAATC AAGGCTTTAA TTTTGCTGAG 
GCAGTTAACT TCTGCACTGT TGATTGGCTG CCGTTGGGCC GCCAGTGCGT GGAGCATTAT 
CGCCTGCTGC ACCGCTACTG CGTCTTTTCC CATGATGAGA TGATATGCAA GATGGCTTCC 
AAGGCTGATG TGTTAGACGT GGTAGTGGCA TCCACTGTTC AGAAGGACAT GGCCATCATG 
ATTGAGGATG AAAAGGCTTT AAGGGAAACT GTCCGTAAAC TGGGAGTGAT TGATTCTGAG 
AGAATGGACT TTGAGCTGTT GCCCGATGAT GAGCGGCAGT GTATAAAGTG CAAAACTACG 
TGCTTCATGT CTGCCATCTC CTGCTCCTGT AAACCTGGCC TGCTTGTTTG CCTGCATCAT 
GTCAAAGAGC TGTGCTCCTG TCCCCCTTAC AAGTATAACC TGCGGTATAG ATACACTCTG 
GATGATCTCT ATCCGATGAT GAATGCGTTG AAGCTTCGAG CAGAGTCGTA CAATGAATGG 
GCCTTAAATG TGAATGAAGC CTTGGAAGCA AAGATTAATA AGAAGAAAAG TCTCGTCAGC 
TTTAAAGCTT TGATTGAAGA ATCAGAAATG AAGAAATTCC CAGACAATGA TCTTTTGCGT 
CACCTTCGCC TAGTTACGCA GGATGCAGAA AAGTGTGCCT CTGTTGCCCA GCAGTTGCTT 
AATGGCAAAA GGCAAACGAG GTATCGATCT GGTGGAGGGA AGTCTCAGAG TCAGCTGACA 
GTGAATGAGC TTCGGCAGTT CGTGACTCAG CTGTGCGCTC TTCCCTGCGT CCTTAGTCAG 
ACACCACTGC TAAAGGATCT CTTGAATCGT GTGGAAGATT TCCAGCAGCA AAGCCAGAGA 
CTGCTGTCTG AGGAGAGGCC CCGTGCTTCT GAGCTTCAGC AGTTGCTGGA TGTCAGCTTC 
ACTTTTGATG TTGAACTTCC ACAGCTAGCT GAGATGCGTA TCCGCTTAGA ACAGGCCCGT 
TGGCTAGAAG AGGTTCAGCA GGCTTGCCTG GACTCCAGCT CCCTTTCTTT GGATGATATG 
AGACGACTCA TAGACTTAGG GGTGGGGCTA GCTCCATATT CTGCCGTGGA GAAAGCTATG 
GCCCGCCTGC AGGAACTGCT AACAGTGTCA GAGCACTGGG ACGACAAAGC CAAGAGTCTC 
CTCAGAGCAA GACCTCGGCA TTCCTTGAGT AGCCTTGCTA CAGCAGTAAA AGAGATGGAG 
GAGATCCCCG CCTATCTGCC CAATGGTACA GTCCTGAAGG ATTCTGTGCA GAAAGCCAGA 
GACTGGGTTC AGGATGTAGA TGCATTGCAG GCAGGAGGAC GCGTGCCAGT GTTAGAAACA 
CTCATTGAAC TTGTCGCAAG AGGCCGATCC ATCCCGGTAC ATCTGAATTC TTTACCCAGA 
TTGGAAATGC TAGTATCCGA GGTTCATGCT TGGAAAGAAA GCGCTGCTAA AACATTCCTG 
CTTGAGAATT CGCCATACTC TCTGTTAGAG GTAAGTTTGC AGTGGAAAAG GAAGCAGAGA 
AAGTTGAAGG ATCCCTTGCC AAGTGGGAAG AAGAGAAGCA CCAAGTTAGA GAGTCTGAGT 
GATCTGGAAA GGGCTCTGAC TGAGAGCAAA GAGACGGCGT CAGCTATGGC AACTCTTGGG 
GAAGCTCGCC TACGAGAGAT GGAAGCTTTG CAGTCTCTCA GATTTGCCAA TGAAGAGAAA 
TTGCTGTCAC CTGCCCAAGA TGTGGAGACG AAGGTTTGCT TGTGTCAGAA GACTCCAGCC 
ACTCCCATGA TTCAGTGTGA ACTCTGCAGG GATGCTTTCC ATACTAGTTG TGTGGCGGTG 
TCCAGTATTT CACAAAGCTC CCGAATCTGG CTTTGTCCTC ACTGTCGAAG GTCAGAGAAG 
CCTCCATTAG AGAAAATTCT GCCTCTGCTG GCCTCCCTAC AGCGTATAAG AGTTCGTCTT 
CCTGAAGGGG ATGCACTCCG ATACATGATT GAAAGAACCG TGAACTGGCA ACATAGAGCC 
CAGCAACTGC TTTCTTCAGG GAATCTAAAA CTTGTGCAGG ACCAAGCGGG TTCTGGACTG 
TTGTTTAGCA GATGGCCAGC CTCAGCAGGA ACGGCGTCAG CAGCAGACAA GGTGTCTCAA 
CCTCCTGGCA CAACATCCTT TTCATTGCCG GAAGACTGGG ACAACAGAAC CTCATATTTA 
CACTCTCCCT TCTCTACCGG TCAGAGTTGT ATCCCCCTTC ATGGTTTGAG TCCAGAGGTG 
AATGAATTGC TGATGGAAGC CCAGTTGCTC CAGGTGTCCC TCCCTGAAGT CCAGGAGCTT 
TATCAGACTT TACTTACGAA GCCAAGCTCT GCTCAGCAAG CCGACCGAAG CTCACCAGTC 
AGACCCAGCA GTGAGAAGAA CGATTGTCTT CGAGGGAAAC GAGATGCAAT CAACAGTCTT 
GAGAGAAAAC TGAAAAGACG CCCAGAAAGA GAAGGCCTTC CCAGTGAACG GTGGGATCGA 
GTTAAAAAAA TGCGGACCCC TCAAAAGAAG AAAATCAAAC TGAGTCACCC CAAGGACATG 
AACAATTTCA AATTAGAAAG AGAGCGTAGC TATGACTTAG TCCGGAATGC TGAAACTCAT 
TCCCTGCCCT CAGACACATC CTACTCCGAG CAGGAGGACT CTGAGGATGA AGATGCCATC 
TGTCCAGCTG TGAGCTGCCT GCAGCCAGAA GGAGATGAGG TGGACTGGGT CCAGTGTGAT 
GGCAGCTGCA ATCAGTGGTT TCATCAGGTC TGTGTTGGTG TCTCTCCAGA GATGGCAGAG 
AAAGAAGACT ACATCTGTGT GCGCTGTACT GGAAAGGACG CACCAAGCCG AAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.
Cell chemical biology24(3)371-380(2017 Mar)
Tumber A,Nuzzi A,Hookway ES,Hatch SB,Velupillai S,Johansson C,Kawamura A,Savitsky P,Yapp C,Szykowska A,Wu N,Bountra C,Strain-Damerell C,Burgess-Brown NA,Ruda GF,Fedorov O,Munro S,England KS,Nowak RP,Schofield CJ,La Thangue NB,Pawlyn C,Davies F,Morgan G,Athanasou N,Müller S,Oppermann U,Brennan PE

Structural analysis of human KDM5B guides histone demethylase inhibitor development.
Nature chemical biology12(7)539-45(2016 07)
Johansson C,Velupillai S,Tumber A,Szykowska A,Hookway ES,Nowak RP,Strain-Damerell C,Gileadi C,Philpott M,Burgess-Brown N,Wu N,Kopec J,Nuzzi A,Steuber H,Egner U,Badock V,Munro S,LaThangue NB,Westaway S,Brown J,Athanasou N,Prinjha R,Brennan PE,Oppermann U

Overexpressed KDM5B is associated with the progression of glioma and promotes glioma cell growth via downregulating p21.
Biochemical and biophysical research communications454(1)221-7(2014 Nov)
Dai B,Hu Z,Huang H,Zhu G,Xiao Z,Wan W,Zhang P,Jia W,Zhang L

The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B.
Protein & cell5(11)837-50(2014 Nov)
Zhang Y,Yang H,Guo X,Rong N,Song Y,Xu Y,Lan W,Zhang X,Liu M,Xu Y,Cao C

Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes.
The Journal of biological chemistry289(25)17620-33(2014 Jun)
Zou MR,Cao J,Liu Z,Huh SJ,Polyak K,Yan Q

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Kdm5b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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