Ace2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ace2
Entrez Gene ID	302668
Full Name	angiotensin I converting enzyme 2
General protein information	Preferred Names angiotensin I converting enzyme 2 Names angiotensin-converting enzyme 2 ACE-related carboxypeptidase angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 anigotensin-converting enzyme-related carboxypeptidase renal angiotensin-converting enzyme 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq14
Summary	enzyme peptidyl-dipeptidase; mouse homolog has a role in regulation of cardiac contractility and regulating Angiotensin 1 and 2 levels [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001012006.1	NP_001012006.1	angiotensin-converting enzyme 2 precursor

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	ACE2	NP_001129168.1
Gallus gallus (chicken)	ACE2	XP_416822.2
Danio rerio (zebrafish)	ace2	NP_001007298.1
Caenorhabditis elegans (roundworm)	acn-1	NP_001024453.1
Xenopus tropicalis (tropical clawed frog)	ace2	XP_002938293.1
Homo sapiens (human)	ACE2	NP_068576.1
Rattus norvegicus (Norway rat)	Ace2	NP_001012006.1
Bos taurus (cattle)	ACE2	NP_001019673.2
Mus musculus (house mouse)	Ace2	NP_001123985.1
Pan troglodytes (chimpanzee)	ACE2	XP_003317420.1
Canis lupus familiaris (dog)	ACE2	NP_001158732.1

Gene Ontology
Bibliography

Related articles in PubMed

Dynamic Variation of RAS on Silicotic Fibrosis Pathogenesis in Rats.
Zhang BN, Zhang X, Xu H, Gao XM, Zhang GZ, Zhang H, Yang F
Current medical science39(4)551-559(2019 Aug)

Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats.
Deng Y, Tan X, Li ML, Wang WZ, Wang YK
Neuroscience bulletin35(1)67-78(2019 Feb)

ACE-2/ANG1-7 ameliorates ER stress-induced apoptosis in seawater aspiration-induced acute lung injury.
Zhang M, Gao Y, Zhao W, Yu G, Jin F
American journal of physiology. Lung cellular and molecular physiology315(6)L1015-L1027(2018 12)

ACE2 activator diminazene aceturate reduces adiposity but preserves lean mass in young and old rats.
Bruce EB, Sakarya Y, Kirichenko N, Toklu HZ, Sumners C, Morgan D, Tümer N, Scarpace PJ, Carter CS
Experimental gerontology111133-140(2018 10)

Angiotensin-converting enzyme 2 activation ameliorates pulmonary endothelial dysfunction in rats with pulmonary arterial hypertension through mediating phosphorylation of endothelial nitric oxide synthase.
Li G, Zhang H, Zhao L, Zhang Y, Yan D, Liu Y
Journal of the American Society of Hypertension : JASH11(12)842-852(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ace2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ace2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01934	NM_001012006.1 Latest version!	Rattus norvegicus angiotensin I converting enzyme 2 (Ace2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ace2 ( NM_001012006.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001012006.1 Rattus norvegicus angiotensin I converting enzyme 2 (Ace2), mRNA.

Price & Availability↑

CloneID	ORa01934
Clone ID Related Accession (Same CDS sequence)	NM_001012006.1
Accession Version	NM_001012006.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2418bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577808000000
Organism	Rattus norvegicus(Norway rat)
Product	angiotensin-converting enzyme 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY881244.1. On Feb 11, 2005 this sequence version replaced XM_228924.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY881244.1, GQ262788.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689597, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGTCAAGCT CCTGCTGGCT CCTTCTCAGC CTTGTTGCTG TTGCTACTGC TCAGTCCCTC 
ATCGAGGAAA AGGCCGAGAG CTTTTTAAAC AAGTTTAACC AGGAAGCTGA AGACCTGTCT 
TATCAAAGTT CACTTGCTTC TTGGAATTAC AACACCAACA TTACGGAGGA GAATGCCCAA 
AAGATGAACG AGGCTGCGGC CAAATGGTCT GCCTTTTATG AAGAACAGTC CAAGATCGCC 
CAAAATTTCT CACTACAAGA AATTCAGAAT GCGACCATCA AGCGTCAACT GAAGGCCCTT 
CAGCAGAGCG GGTCTTCAGC GCTGTCACCA GACAAGAACA AACAGTTGAA CACAATTCTA 
AACACCATGA GCACCATTTA CAGTACTGGA AAAGTTTGCA ACTCAATGAA TCCACAAGAA 
TGTTTTTTAC TTGAACCAGG ATTGGACGAA ATAATGGCAA CAAGCACAGA CTACAATCGT 
AGGCTCTGGG CTTGGGAGGG CTGGAGGGCT GAGGTCGGCA AGCAGCTGAG GCCGTTATAT 
GAAGAGTATG TGGTCCTGAA AAATGAGATG GCAAGAGCAA ACAATTATGA AGACTATGGG 
GATTATTGGC GAGGGGATTA TGAAGCAGAG GGAGTAGAAG GTTACAACTA CAACCGAAAC 
CAGTTGATCG AAGACGTAGA AAATACCTTC AAAGAGATCA AACCGTTGTA TGAGCAACTT 
CATGCCTATG TGAGAACGAA GTTGATGGAA GTGTACCCTT CTTACATCAG CCCTACTGGA 
TGCCTCCCTG CTCATTTGCT TGGTGATATG TGGGGTAGGT TTTGGACAAA TCTGTACCCT 
TTGACTACTC CCTTTCTTCA GAAACCAAAC ATAGATGTTA CTGATGCAAT GGTGAATCAG 
AGCTGGGATG CAGAAAGAAT ATTTAAAGAG GCAGAGAAGT TCTTCGTTTC TGTTGGCCTT 
CCTCAAATGA CTCCGGGATT CTGGACAAAC TCCATGCTGA CTGAGCCAGG AGATGACCGG 
AAAGTTGTCT GCCACCCCAC AGCTTGGGAT CTGGGACATG GAGACTTCAG AATCAAGATG 
TGCACAAAGG TCACAATGGA CAACTTCTTG ACAGCCCATC ATGAGATGGG ACACATCCAA 
TATGACATGG CATATGCCAA GCAACCTTTC CTGCTAAGAA ACGGAGCCAA TGAAGGGTTC 
CATGAAGCCG TTGGAGAAAT CATGTCACTT TCTGCAGCTA CCCCCAAACA TTTGAAATCT 
ATTGGTCTTC TGCCATCCAA TTTTCAAGAA GACAATGAAA CAGAAATAAA CTTCCTACTC 
AAACAGGCAT TGACAATTGT TGGAACGCTG CCATTTACTT ACATGTTAGA GAAGTGGAGG 
TGGATGGTCT TTCAGGATAA AATTCCCAGA GAACAGTGGA CCAAAAAGTG GTGGGAGATG 
AAGCGGGAGA TCGTTGGTGT GGTGGAGCCT CTGCCTCATG ATGAAACATA CTGTGACCCT 
GCATCTCTGT TCCATGTCTC TAATGATTAC TCATTCATTC GATATTACAC AAGGACCATT 
TATCAATTCC AGTTTCAAGA AGCTCTTTGT CAAGCAGCTA AACATGATGG CCCACTACAC 
AAATGTGACA TCTCAAATTC CACTGAAGCT GGGCAGAAGT TGCTCAATAT GCTGAGTCTT 
GGAAACTCAG GGCCCTGGAC CCTAGCCTTG GAAAATGTGG TAGGATCAAG GAATATGGAT 
GTAAAACCAC TGCTCAATTA CTTCCAACCA TTGTTTGTCT GGCTGAAAGA GCAGAACAGG 
AATTCGACTG TGGGGTGGAG CACTGACTGG AGCCCATATG CCGACCAAAG CATTAAAGTG 
AGGATAAGCC TAAAATCAGC TCTTGGGAAA AATGCGTATG AATGGACCGA CAACGAAATG 
TACCTATTCC GATCATCTGT TGCCTATGCC ATGAGAGAGT ATTTTTCAAG GGAAAAGAAC 
CAGACAGTTC CTTTTGGGGA GGCAGACGTA TGGGTGAGTG ATTTGAAACC AAGAGTCTCC 
TTCAACTTCT TTGTCACTTC ACCCAAAAAT GTGTCTGACA TCATTCCCAG AAGTGAAGTT 
GAAGAGGCCA TCAGGATGTC TCGGGGCCGT ATCAATGATA TTTTTGGTCT GAATGATAAC 
AGCCTGGAGT TTCTGGGGAT CTACCCAACA CTTAAGCCAC CTTACGAGCC TCCTGTCACC 
ATATGGCTGA TTATTTTTGG TGTCGTGATG GGAACGGTAG TGGTTGGCAT TGTTATCCTG 
ATCGTCACTG GGATCAAAGG TCGAAAGAAG AAAAATGAAA CAAAAAGAGA AGAGAATCCT 
TATGACTCCA TGGACATTGG CAAAGGAGAA AGTAACGCAG GATTCCAAAA CAGTGATGAT 
GCTCAAACTT CATTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012006.1
CDS	1..2418
Translation	MSSSCWLLLSLVAVATAQSLIEEKAESFLNKFNQEAEDLSYQSSLASWNYNTNITEENAQKMNEAAAKWSAFYEEQSKIAQNFSLQEIQNATIKRQLKALQQSGSSALSPDKNKQLNTILNTMSTIYSTGKVCNSMNPQECFLLEPGLDEIMATSTDYNRRLWAWEGWRAEVGKQLRPLYEEYVVLKNEMARANNYEDYGDYWRGDYEAEGVEGYNYNRNQLIEDVENTFKEIKPLYEQLHAYVRTKLMEVYPSYISPTGCLPAHLLGDMWGRFWTNLYPLTTPFLQKPNIDVTDAMVNQSWDAERIFKEAEKFFVSVGLPQMTPGFWTNSMLTEPGDDRKVVCHPTAWDLGHGDFRIKMCTKVTMDNFLTAHHEMGHIQYDMAYAKQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLPSNFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFQDKIPREQWTKKWWEMKREIVGVVEPLPHDETYCDPASLFHVSNDYSFIRYYTRTIYQFQFQEALCQAAKHDGPLHKCDISNSTEAGQKLLNMLSLGNSGPWTLALENVVGSRNMDVKPLLNYFQPLFVWLKEQNRNSTVGWSTDWSPYADQSIKVRISLKSALGKNAYEWTDNEMYLFRSSVAYAMREYFSREKNQTVPFGEADVWVSDLKPRVSFNFFVTSPKNVSDIIPRSEVEEAIRMSRGRINDIFGLNDNSLEFLGIYPTLKPPYEPPVTIWLIIFGVVMGTVVVGIVILIVTGIKGRKKKNETKREENPYDSMDIGKGESNAGFQNSDDAQTSF

Target ORF information:

RefSeq Version	NM_001012006.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus angiotensin I converting enzyme 2 (Ace2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001012006.1

ORF Insert Sequence:

ATGTCAAGCT CCTGCTGGCT CCTTCTCAGC CTTGTTGCTG TTGCTACTGC TCAGTCCCTC 
ATCGAGGAAA AGGCCGAGAG CTTTTTAAAC AAGTTTAACC AGGAAGCTGA AGACCTGTCT 
TATCAAAGTT CACTTGCTTC TTGGAATTAC AACACCAACA TTACGGAGGA GAATGCCCAA 
AAGATGAACG AGGCTGCGGC CAAATGGTCT GCCTTTTATG AAGAACAGTC CAAGATCGCC 
CAAAATTTCT CACTACAAGA AATTCAGAAT GCGACCATCA AGCGTCAACT GAAGGCCCTT 
CAGCAGAGCG GGTCTTCAGC GCTGTCACCA GACAAGAACA AACAGTTGAA CACAATTCTA 
AACACCATGA GCACCATTTA CAGTACTGGA AAAGTTTGCA ACTCAATGAA TCCACAAGAA 
TGTTTTTTAC TTGAACCAGG ATTGGACGAA ATAATGGCAA CAAGCACAGA CTACAATCGT 
AGGCTCTGGG CTTGGGAGGG CTGGAGGGCT GAGGTCGGCA AGCAGCTGAG GCCGTTATAT 
GAAGAGTATG TGGTCCTGAA AAATGAGATG GCAAGAGCAA ACAATTATGA AGACTATGGG 
GATTATTGGC GAGGGGATTA TGAAGCAGAG GGAGTAGAAG GTTACAACTA CAACCGAAAC 
CAGTTGATCG AAGACGTAGA AAATACCTTC AAAGAGATCA AACCGTTGTA TGAGCAACTT 
CATGCCTATG TGAGAACGAA GTTGATGGAA GTGTACCCTT CTTACATCAG CCCTACTGGA 
TGCCTCCCTG CTCATTTGCT TGGTGATATG TGGGGTAGGT TTTGGACAAA TCTGTACCCT 
TTGACTACTC CCTTTCTTCA GAAACCAAAC ATAGATGTTA CTGATGCAAT GGTGAATCAG 
AGCTGGGATG CAGAAAGAAT ATTTAAAGAG GCAGAGAAGT TCTTCGTTTC TGTTGGCCTT 
CCTCAAATGA CTCCGGGATT CTGGACAAAC TCCATGCTGA CTGAGCCAGG AGATGACCGG 
AAAGTTGTCT GCCACCCCAC AGCTTGGGAT CTGGGACATG GAGACTTCAG AATCAAGATG 
TGCACAAAGG TCACAATGGA CAACTTCTTG ACAGCCCATC ATGAGATGGG ACACATCCAA 
TATGACATGG CATATGCCAA GCAACCTTTC CTGCTAAGAA ACGGAGCCAA TGAAGGGTTC 
CATGAAGCCG TTGGAGAAAT CATGTCACTT TCTGCAGCTA CCCCCAAACA TTTGAAATCT 
ATTGGTCTTC TGCCATCCAA TTTTCAAGAA GACAATGAAA CAGAAATAAA CTTCCTACTC 
AAACAGGCAT TGACAATTGT TGGAACGCTG CCATTTACTT ACATGTTAGA GAAGTGGAGG 
TGGATGGTCT TTCAGGATAA AATTCCCAGA GAACAGTGGA CCAAAAAGTG GTGGGAGATG 
AAGCGGGAGA TCGTTGGTGT GGTGGAGCCT CTGCCTCATG ATGAAACATA CTGTGACCCT 
GCATCTCTGT TCCATGTCTC TAATGATTAC TCATTCATTC GATATTACAC AAGGACCATT 
TATCAATTCC AGTTTCAAGA AGCTCTTTGT CAAGCAGCTA AACATGATGG CCCACTACAC 
AAATGTGACA TCTCAAATTC CACTGAAGCT GGGCAGAAGT TGCTCAATAT GCTGAGTCTT 
GGAAACTCAG GGCCCTGGAC CCTAGCCTTG GAAAATGTGG TAGGATCAAG GAATATGGAT 
GTAAAACCAC TGCTCAATTA CTTCCAACCA TTGTTTGTCT GGCTGAAAGA GCAGAACAGG 
AATTCGACTG TGGGGTGGAG CACTGACTGG AGCCCATATG CCGACCAAAG CATTAAAGTG 
AGGATAAGCC TAAAATCAGC TCTTGGGAAA AATGCGTATG AATGGACCGA CAACGAAATG 
TACCTATTCC GATCATCTGT TGCCTATGCC ATGAGAGAGT ATTTTTCAAG GGAAAAGAAC 
CAGACAGTTC CTTTTGGGGA GGCAGACGTA TGGGTGAGTG ATTTGAAACC AAGAGTCTCC 
TTCAACTTCT TTGTCACTTC ACCCAAAAAT GTGTCTGACA TCATTCCCAG AAGTGAAGTT 
GAAGAGGCCA TCAGGATGTC TCGGGGCCGT ATCAATGATA TTTTTGGTCT GAATGATAAC 
AGCCTGGAGT TTCTGGGGAT CTACCCAACA CTTAAGCCAC CTTACGAGCC TCCTGTCACC 
ATATGGCTGA TTATTTTTGG TGTCGTGATG GGAACGGTAG TGGTTGGCAT TGTTATCCTG 
ATCGTCACTG GGATCAAAGG TCGAAAGAAG AAAAATGAAA CAAAAAGAGA AGAGAATCCT 
TATGACTCCA TGGACATTGG CAAAGGAGAA AGTAACGCAG GATTCCAAAA CAGTGATGAT 
GCTCAAACTT CATTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dynamic Variation of RAS on Silicotic Fibrosis Pathogenesis in Rats.
Current medical science39(4)551-559(2019 Aug)
Zhang BN,Zhang X,Xu H,Gao XM,Zhang GZ,Zhang H,Yang F

Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats.
Neuroscience bulletin35(1)67-78(2019 Feb)
Deng Y,Tan X,Li ML,Wang WZ,Wang YK

ACE-2/ANG1-7 ameliorates ER stress-induced apoptosis in seawater aspiration-induced acute lung injury.
American journal of physiology. Lung cellular and molecular physiology315(6)L1015-L1027(2018 12)
Zhang M,Gao Y,Zhao W,Yu G,Jin F

ACE2 activator diminazene aceturate reduces adiposity but preserves lean mass in young and old rats.
Experimental gerontology111133-140(2018 10)
Bruce EB,Sakarya Y,Kirichenko N,Toklu HZ,Sumners C,Morgan D,Tümer N,Scarpace PJ,Carter CS

Angiotensin-converting enzyme 2 activation ameliorates pulmonary endothelial dysfunction in rats with pulmonary arterial hypertension through mediating phosphorylation of endothelial nitric oxide synthase.
Journal of the American Society of Hypertension : JASH11(12)842-852(2017 Dec)
Li G,Zhang H,Zhao L,Zhang Y,Yan D,Liu Y

REQUEST A QUOTE

EMAIL

gene@genscript.com

PHONE

1-877-436-7274

ONLINE FORM

Online Quote Submission

ONLINE FORM

Online Quote Submission

Ace2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

News & Blogs

REQUEST A QUOTE

EMAIL

PHONE

ONLINE FORM

ONLINE FORM