Ace2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ace2
Entrez Gene ID	70008
Full Name	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Synonyms	2010305L05Rik
General protein information	Preferred Names angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Names angiotensin-converting enzyme 2 ACE-related carboxypeptidase angiotensin I converting enzyme 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X F5\|X 76.12 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_027286.4	NP_081562.2	angiotensin-converting enzyme 2 precursor
NM_001130513.1	NP_001123985.1	angiotensin-converting enzyme 2 precursor

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	ACE2	NP_001129168.1
Gallus gallus (chicken)	ACE2	XP_416822.2
Danio rerio (zebrafish)	ace2	NP_001007298.1
Caenorhabditis elegans (roundworm)	acn-1	NP_001024453.1
Xenopus tropicalis (tropical clawed frog)	ace2	XP_002938293.1
Homo sapiens (human)	ACE2	NP_068576.1
Rattus norvegicus (Norway rat)	Ace2	NP_001012006.1
Bos taurus (cattle)	ACE2	NP_001019673.2
Mus musculus (house mouse)	Ace2	NP_001123985.1
Pan troglodytes (chimpanzee)	ACE2	XP_003317420.1
Canis lupus familiaris (dog)	ACE2	NP_001158732.1

Gene Ontology
Bibliography

Related articles in PubMed

Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice.
Takeshita H, Yamamoto K, Nozato S, Takeda M, Fukada SI, Inagaki T, Tsuchimochi H, Shirai M, Nozato Y, Fujimoto T, Imaizumi Y, Yokoyama S, Nagasawa M, Hamano G, Hongyo K, Kawai T, Hanasaki-Yamamoto H, Takeda S, Takahashi T, Akasaka H, Itoh N, Takami Y, Takeya Y, Sugimoto K, Nakagami H, Rakugi H
Journal of cachexia, sarcopenia and muscle9(5)975-986(2018 10)

Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response.
Klempin F, Mosienko V, Matthes S, Villela DC, Todiras M, Penninger JM, Bader M, Santos RAS, Alenina N
Cellular and molecular life sciences : CMLS75(19)3625-3634(2018 Oct)

Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction.
Duan Y, Beli E, Li Calzi S, Quigley JL, Miller RC, Moldovan L, Feng D, Salazar TE, Hazra S, Al-Sabah J, Chalam KV, Phuong Trinh TL, Meroueh M, Markel TA, Murray MC, Vyas RJ, Boulton ME, Parsons-Wingerter P, Oudit GY, Obukhov AG, Grant MB
Stem cells (Dayton, Ohio)36(9)1430-1440(2018 09)

Sex dimorphism in ANGII-mediated crosstalk between ACE2 and ACE in diabetic nephropathy.
Clotet-Freixas S, Soler MJ, Palau V, Anguiano L, Gimeno J, Konvalinka A, Pascual J, Riera M
Laboratory investigation; a journal of technical methods and pathology98(9)1237-1249(2018 09)

Sini decoction alleviates E. coli induced acute lung injury in mice via equilibrating ACE-AngII-AT1R and ACE2-Ang-(1-7)-Mas axis.
Liu J, Chen Q, Liu S, Yang X, Zhang Y, Huang F
Life sciences208139-148(2018 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ace2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ace2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22565	NM_001130513.1 Latest version!	Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OMu22565	NM_027286.4 Latest version!	Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ace2 ( NM_027286.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081562.2 Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu22565
Clone ID Related Accession (Same CDS sequence)	NM_027286.4 , NM_001130513.1
Accession Version	NM_027286.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2418bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Mus musculus(house mouse)
Product	angiotensin-converting enzyme 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AI115946.1 and AK141604.1. On Jul 26, 2008 this sequence version replaced NM_027286.3. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK141604.1, AB053181.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END##

ATGTCCAGCT CCTCCTGGCT CCTTCTCAGC CTTGTTGCTG TTACTACTGC TCAGTCCCTC 
ACCGAGGAAA ATGCCAAGAC ATTTTTAAAC AACTTTAATC AGGAAGCTGA AGACCTGTCT 
TATCAAAGTT CACTTGCTTC TTGGAATTAT AATACTAACA TTACTGAAGA AAATGCCCAA 
AAGATGAGTG AGGCTGCAGC CAAATGGTCT GCCTTTTATG AAGAACAGTC TAAGACTGCC 
CAAAGTTTCT CACTACAAGA AATCCAGACT CCGATCATCA AGCGTCAACT ACAGGCCCTT 
CAGCAAAGTG GGTCTTCAGC ACTCTCAGCA GACAAGAACA AACAGTTGAA CACAATTCTG 
AACACCATGA GCACCATTTA CAGTACTGGA AAAGTTTGCA ACCCAAAGAA CCCACAAGAA 
TGCTTATTAC TTGAGCCAGG ATTGGATGAA ATAATGGCGA CAAGCACAGA CTACAACTCT 
AGGCTCTGGG CATGGGAGGG CTGGAGGGCT GAGGTTGGCA AGCAGCTGAG GCCGTTGTAT 
GAAGAGTATG TGGTCCTGAA AAACGAGATG GCAAGAGCAA ACAATTATAA CGACTATGGG 
GATTATTGGA GAGGGGACTA TGAAGCAGAG GGAGCAGATG GCTACAACTA TAACCGTAAC 
CAGTTGATTG AAGATGTAGA ACGTACCTTC GCAGAGATCA AGCCATTGTA TGAGCATCTT 
CATGCCTATG TGAGGAGGAA GTTGATGGAT ACCTACCCTT CCTACATCAG CCCCACTGGA 
TGCCTCCCTG CCCATTTGCT TGGTGATATG TGGGGTAGAT TTTGGACAAA TCTGTACCCT 
TTGACTGTTC CCTTTGCACA GAAACCAAAC ATAGATGTTA CTGATGCAAT GATGAATCAG 
GGCTGGGATG CAGAAAGGAT ATTTCAAGAG GCAGAGAAAT TCTTTGTTTC TGTTGGCCTT 
CCTCATATGA CTCAAGGATT CTGGGCAAAC TCTATGCTGA CTGAGCCAGC AGATGGCCGG 
AAAGTTGTCT GCCACCCCAC AGCTTGGGAT CTGGGACACG GAGACTTCAG AATCAAGATG 
TGTACAAAGG TCACAATGGA CAACTTCTTG ACAGCCCATC ACGAGATGGG ACACATCCAA 
TATGACATGG CATATGCCAG GCAACCTTTC CTGCTAAGAA ACGGAGCCAA TGAAGGGTTC 
CATGAAGCTG TTGGAGAAAT CATGTCACTT TCTGCAGCTA CCCCCAAGCA TCTGAAATCC 
ATTGGTCTTC TGCCATCCGA TTTTCAAGAA GATAGCGAAA CAGAGATAAA CTTCCTACTG 
AAACAGGCAT TGACAATTGT TGGAACACTA CCGTTTACTT ACATGTTAGA GAAGTGGAGG 
TGGATGGTCT TTCGGGGTGA AATTCCCAAA GAGCAGTGGA TGAAAAAGTG GTGGGAGATG 
AAGCGGGAGA TCGTTGGTGT GGTGGAGCCT CTGCCTCATG ATGAAACATA CTGTGACCCT 
GCATCTCTGT TCCATGTTTC TAATGATTAC TCATTCATTC GATATTACAC AAGGACCATT 
TACCAATTCC AGTTTCAAGA AGCTCTTTGT CAAGCAGCTA AGTATAATGG TTCTCTGCAC 
AAATGTGACA TCTCAAATTC CACTGAAGCT GGGCAGAAGT TGCTCAAGAT GCTGAGTCTT 
GGAAATTCAG AGCCCTGGAC CAAAGCCTTG GAAAATGTGG TAGGAGCAAG GAATATGGAT 
GTAAAACCAC TGCTCAATTA CTTCCAACCG TTGTTTGACT GGCTGAAAGA GCAGAACAGA 
AATTCTTTTG TGGGGTGGAA CACTGAATGG AGCCCATATG CCGACCAAAG CATTAAAGTG 
AGGATAAGCC TAAAATCAGC TCTTGGAGCT AATGCATATG AATGGACCAA CAACGAAATG 
TTCCTGTTCC GATCATCTGT TGCATATGCC ATGAGAAAGT ATTTTTCAAT AATCAAAAAC 
CAGACAGTTC CTTTTCTAGA GGAAGATGTA CGAGTGAGTG ATTTGAAACC AAGAGTCTCC 
TTCTACTTCT TTGTCACCTC ACCCCAAAAT GTGTCTGATG TCATTCCTAG AAGTGAAGTT 
GAAGATGCCA TCAGGATGTC TCGGGGCCGC ATCAATGATG TCTTTGGCCT GAATGATAAC 
AGCCTGGAGT TTCTGGGGAT TCACCCAACA CTTGAGCCAC CTTACCAGCC TCCTGTCACC 
ATATGGCTGA TTATTTTTGG TGTTGTGATG GCACTGGTAG TGGTTGGCAT CATCATCCTG 
ATTGTCACTG GGATCAAAGG TCGAAAGAAG AAAAATGAAA CAAAAAGAGA AGAGAACCCT 
TATGACTCGA TGGACATTGG AAAAGGAGAA AGCAATGCAG GATTCCAAAA CAGTGATGAT 
GCTCAGACTT CCTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081562.2
CDS	183..2600
Translation	MSSSSWLLLSLVAVTTAQSLTEENAKTFLNNFNQEAEDLSYQSSLASWNYNTNITEENAQKMSEAAAKWSAFYEEQSKTAQSFSLQEIQTPIIKRQLQALQQSGSSALSADKNKQLNTILNTMSTIYSTGKVCNPKNPQECLLLEPGLDEIMATSTDYNSRLWAWEGWRAEVGKQLRPLYEEYVVLKNEMARANNYNDYGDYWRGDYEAEGADGYNYNRNQLIEDVERTFAEIKPLYEHLHAYVRRKLMDTYPSYISPTGCLPAHLLGDMWGRFWTNLYPLTVPFAQKPNIDVTDAMMNQGWDAERIFQEAEKFFVSVGLPHMTQGFWANSMLTEPADGRKVVCHPTAWDLGHGDFRIKMCTKVTMDNFLTAHHEMGHIQYDMAYARQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLPSDFQEDSETEINFLLKQALTIVGTLPFTYMLEKWRWMVFRGEIPKEQWMKKWWEMKREIVGVVEPLPHDETYCDPASLFHVSNDYSFIRYYTRTIYQFQFQEALCQAAKYNGSLHKCDISNSTEAGQKLLKMLSLGNSEPWTKALENVVGARNMDVKPLLNYFQPLFDWLKEQNRNSFVGWNTEWSPYADQSIKVRISLKSALGANAYEWTNNEMFLFRSSVAYAMRKYFSIIKNQTVPFLEEDVRVSDLKPRVSFYFFVTSPQNVSDVIPRSEVEDAIRMSRGRINDVFGLNDNSLEFLGIHPTLEPPYQPPVTIWLIIFGVVMALVVVGIIILIVTGIKGRKKKNETKREENPYDSMDIGKGESNAGFQNSDDAQTSF

Target ORF information:

RefSeq Version	NM_027286.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027286.4

ORF Insert Sequence:

ATGTCCAGCT CCTCCTGGCT CCTTCTCAGC CTTGTTGCTG TTACTACTGC TCAGTCCCTC 
ACCGAGGAAA ATGCCAAGAC ATTTTTAAAC AACTTTAATC AGGAAGCTGA AGACCTGTCT 
TATCAAAGTT CACTTGCTTC TTGGAATTAT AATACTAACA TTACTGAAGA AAATGCCCAA 
AAGATGAGTG AGGCTGCAGC CAAATGGTCT GCCTTTTATG AAGAACAGTC TAAGACTGCC 
CAAAGTTTCT CACTACAAGA AATCCAGACT CCGATCATCA AGCGTCAACT ACAGGCCCTT 
CAGCAAAGTG GGTCTTCAGC ACTCTCAGCA GACAAGAACA AACAGTTGAA CACAATTCTG 
AACACCATGA GCACCATTTA CAGTACTGGA AAAGTTTGCA ACCCAAAGAA CCCACAAGAA 
TGCTTATTAC TTGAGCCAGG ATTGGATGAA ATAATGGCGA CAAGCACAGA CTACAACTCT 
AGGCTCTGGG CATGGGAGGG CTGGAGGGCT GAGGTTGGCA AGCAGCTGAG GCCGTTGTAT 
GAAGAGTATG TGGTCCTGAA AAACGAGATG GCAAGAGCAA ACAATTATAA CGACTATGGG 
GATTATTGGA GAGGGGACTA TGAAGCAGAG GGAGCAGATG GCTACAACTA TAACCGTAAC 
CAGTTGATTG AAGATGTAGA ACGTACCTTC GCAGAGATCA AGCCATTGTA TGAGCATCTT 
CATGCCTATG TGAGGAGGAA GTTGATGGAT ACCTACCCTT CCTACATCAG CCCCACTGGA 
TGCCTCCCTG CCCATTTGCT TGGTGATATG TGGGGTAGAT TTTGGACAAA TCTGTACCCT 
TTGACTGTTC CCTTTGCACA GAAACCAAAC ATAGATGTTA CTGATGCAAT GATGAATCAG 
GGCTGGGATG CAGAAAGGAT ATTTCAAGAG GCAGAGAAAT TCTTTGTTTC TGTTGGCCTT 
CCTCATATGA CTCAAGGATT CTGGGCAAAC TCTATGCTGA CTGAGCCAGC AGATGGCCGG 
AAAGTTGTCT GCCACCCCAC AGCTTGGGAT CTGGGACACG GAGACTTCAG AATCAAGATG 
TGTACAAAGG TCACAATGGA CAACTTCTTG ACAGCCCATC ACGAGATGGG ACACATCCAA 
TATGACATGG CATATGCCAG GCAACCTTTC CTGCTAAGAA ACGGAGCCAA TGAAGGGTTC 
CATGAAGCTG TTGGAGAAAT CATGTCACTT TCTGCAGCTA CCCCCAAGCA TCTGAAATCC 
ATTGGTCTTC TGCCATCCGA TTTTCAAGAA GATAGCGAAA CAGAGATAAA CTTCCTACTG 
AAACAGGCAT TGACAATTGT TGGAACACTA CCGTTTACTT ACATGTTAGA GAAGTGGAGG 
TGGATGGTCT TTCGGGGTGA AATTCCCAAA GAGCAGTGGA TGAAAAAGTG GTGGGAGATG 
AAGCGGGAGA TCGTTGGTGT GGTGGAGCCT CTGCCTCATG ATGAAACATA CTGTGACCCT 
GCATCTCTGT TCCATGTTTC TAATGATTAC TCATTCATTC GATATTACAC AAGGACCATT 
TACCAATTCC AGTTTCAAGA AGCTCTTTGT CAAGCAGCTA AGTATAATGG TTCTCTGCAC 
AAATGTGACA TCTCAAATTC CACTGAAGCT GGGCAGAAGT TGCTCAAGAT GCTGAGTCTT 
GGAAATTCAG AGCCCTGGAC CAAAGCCTTG GAAAATGTGG TAGGAGCAAG GAATATGGAT 
GTAAAACCAC TGCTCAATTA CTTCCAACCG TTGTTTGACT GGCTGAAAGA GCAGAACAGA 
AATTCTTTTG TGGGGTGGAA CACTGAATGG AGCCCATATG CCGACCAAAG CATTAAAGTG 
AGGATAAGCC TAAAATCAGC TCTTGGAGCT AATGCATATG AATGGACCAA CAACGAAATG 
TTCCTGTTCC GATCATCTGT TGCATATGCC ATGAGAAAGT ATTTTTCAAT AATCAAAAAC 
CAGACAGTTC CTTTTCTAGA GGAAGATGTA CGAGTGAGTG ATTTGAAACC AAGAGTCTCC 
TTCTACTTCT TTGTCACCTC ACCCCAAAAT GTGTCTGATG TCATTCCTAG AAGTGAAGTT 
GAAGATGCCA TCAGGATGTC TCGGGGCCGC ATCAATGATG TCTTTGGCCT GAATGATAAC 
AGCCTGGAGT TTCTGGGGAT TCACCCAACA CTTGAGCCAC CTTACCAGCC TCCTGTCACC 
ATATGGCTGA TTATTTTTGG TGTTGTGATG GCACTGGTAG TGGTTGGCAT CATCATCCTG 
ATTGTCACTG GGATCAAAGG TCGAAAGAAG AAAAATGAAA CAAAAAGAGA AGAGAACCCT 
TATGACTCGA TGGACATTGG AAAAGGAGAA AGCAATGCAG GATTCCAAAA CAGTGATGAT 
GCTCAGACTT CCTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ace2 ( NM_001130513.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001123985.1 Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu22565
Clone ID Related Accession (Same CDS sequence)	NM_027286.4 , NM_001130513.1
Accession Version	NM_001130513.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2418bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Mus musculus(house mouse)
Product	angiotensin-converting enzyme 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY722909.1 and AK141604.1. Transcript Variant: This variant (1) represents the longer transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EF408739.1, EF408740.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849387, SAMN01164133 [ECO:0000348] ##Evidence-Data-END##

ATGTCCAGCT CCTCCTGGCT CCTTCTCAGC CTTGTTGCTG TTACTACTGC TCAGTCCCTC 
ACCGAGGAAA ATGCCAAGAC ATTTTTAAAC AACTTTAATC AGGAAGCTGA AGACCTGTCT 
TATCAAAGTT CACTTGCTTC TTGGAATTAT AATACTAACA TTACTGAAGA AAATGCCCAA 
AAGATGAGTG AGGCTGCAGC CAAATGGTCT GCCTTTTATG AAGAACAGTC TAAGACTGCC 
CAAAGTTTCT CACTACAAGA AATCCAGACT CCGATCATCA AGCGTCAACT ACAGGCCCTT 
CAGCAAAGTG GGTCTTCAGC ACTCTCAGCA GACAAGAACA AACAGTTGAA CACAATTCTG 
AACACCATGA GCACCATTTA CAGTACTGGA AAAGTTTGCA ACCCAAAGAA CCCACAAGAA 
TGCTTATTAC TTGAGCCAGG ATTGGATGAA ATAATGGCGA CAAGCACAGA CTACAACTCT 
AGGCTCTGGG CATGGGAGGG CTGGAGGGCT GAGGTTGGCA AGCAGCTGAG GCCGTTGTAT 
GAAGAGTATG TGGTCCTGAA AAACGAGATG GCAAGAGCAA ACAATTATAA CGACTATGGG 
GATTATTGGA GAGGGGACTA TGAAGCAGAG GGAGCAGATG GCTACAACTA TAACCGTAAC 
CAGTTGATTG AAGATGTAGA ACGTACCTTC GCAGAGATCA AGCCATTGTA TGAGCATCTT 
CATGCCTATG TGAGGAGGAA GTTGATGGAT ACCTACCCTT CCTACATCAG CCCCACTGGA 
TGCCTCCCTG CCCATTTGCT TGGTGATATG TGGGGTAGAT TTTGGACAAA TCTGTACCCT 
TTGACTGTTC CCTTTGCACA GAAACCAAAC ATAGATGTTA CTGATGCAAT GATGAATCAG 
GGCTGGGATG CAGAAAGGAT ATTTCAAGAG GCAGAGAAAT TCTTTGTTTC TGTTGGCCTT 
CCTCATATGA CTCAAGGATT CTGGGCAAAC TCTATGCTGA CTGAGCCAGC AGATGGCCGG 
AAAGTTGTCT GCCACCCCAC AGCTTGGGAT CTGGGACACG GAGACTTCAG AATCAAGATG 
TGTACAAAGG TCACAATGGA CAACTTCTTG ACAGCCCATC ACGAGATGGG ACACATCCAA 
TATGACATGG CATATGCCAG GCAACCTTTC CTGCTAAGAA ACGGAGCCAA TGAAGGGTTC 
CATGAAGCTG TTGGAGAAAT CATGTCACTT TCTGCAGCTA CCCCCAAGCA TCTGAAATCC 
ATTGGTCTTC TGCCATCCGA TTTTCAAGAA GATAGCGAAA CAGAGATAAA CTTCCTACTG 
AAACAGGCAT TGACAATTGT TGGAACACTA CCGTTTACTT ACATGTTAGA GAAGTGGAGG 
TGGATGGTCT TTCGGGGTGA AATTCCCAAA GAGCAGTGGA TGAAAAAGTG GTGGGAGATG 
AAGCGGGAGA TCGTTGGTGT GGTGGAGCCT CTGCCTCATG ATGAAACATA CTGTGACCCT 
GCATCTCTGT TCCATGTTTC TAATGATTAC TCATTCATTC GATATTACAC AAGGACCATT 
TACCAATTCC AGTTTCAAGA AGCTCTTTGT CAAGCAGCTA AGTATAATGG TTCTCTGCAC 
AAATGTGACA TCTCAAATTC CACTGAAGCT GGGCAGAAGT TGCTCAAGAT GCTGAGTCTT 
GGAAATTCAG AGCCCTGGAC CAAAGCCTTG GAAAATGTGG TAGGAGCAAG GAATATGGAT 
GTAAAACCAC TGCTCAATTA CTTCCAACCG TTGTTTGACT GGCTGAAAGA GCAGAACAGA 
AATTCTTTTG TGGGGTGGAA CACTGAATGG AGCCCATATG CCGACCAAAG CATTAAAGTG 
AGGATAAGCC TAAAATCAGC TCTTGGAGCT AATGCATATG AATGGACCAA CAACGAAATG 
TTCCTGTTCC GATCATCTGT TGCATATGCC ATGAGAAAGT ATTTTTCAAT AATCAAAAAC 
CAGACAGTTC CTTTTCTAGA GGAAGATGTA CGAGTGAGTG ATTTGAAACC AAGAGTCTCC 
TTCTACTTCT TTGTCACCTC ACCCCAAAAT GTGTCTGATG TCATTCCTAG AAGTGAAGTT 
GAAGATGCCA TCAGGATGTC TCGGGGCCGC ATCAATGATG TCTTTGGCCT GAATGATAAC 
AGCCTGGAGT TTCTGGGGAT TCACCCAACA CTTGAGCCAC CTTACCAGCC TCCTGTCACC 
ATATGGCTGA TTATTTTTGG TGTTGTGATG GCACTGGTAG TGGTTGGCAT CATCATCCTG 
ATTGTCACTG GGATCAAAGG TCGAAAGAAG AAAAATGAAA CAAAAAGAGA AGAGAACCCT 
TATGACTCGA TGGACATTGG AAAAGGAGAA AGCAATGCAG GATTCCAAAA CAGTGATGAT 
GCTCAGACTT CCTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001123985.1
CDS	331..2748
Translation	MSSSSWLLLSLVAVTTAQSLTEENAKTFLNNFNQEAEDLSYQSSLASWNYNTNITEENAQKMSEAAAKWSAFYEEQSKTAQSFSLQEIQTPIIKRQLQALQQSGSSALSADKNKQLNTILNTMSTIYSTGKVCNPKNPQECLLLEPGLDEIMATSTDYNSRLWAWEGWRAEVGKQLRPLYEEYVVLKNEMARANNYNDYGDYWRGDYEAEGADGYNYNRNQLIEDVERTFAEIKPLYEHLHAYVRRKLMDTYPSYISPTGCLPAHLLGDMWGRFWTNLYPLTVPFAQKPNIDVTDAMMNQGWDAERIFQEAEKFFVSVGLPHMTQGFWANSMLTEPADGRKVVCHPTAWDLGHGDFRIKMCTKVTMDNFLTAHHEMGHIQYDMAYARQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLPSDFQEDSETEINFLLKQALTIVGTLPFTYMLEKWRWMVFRGEIPKEQWMKKWWEMKREIVGVVEPLPHDETYCDPASLFHVSNDYSFIRYYTRTIYQFQFQEALCQAAKYNGSLHKCDISNSTEAGQKLLKMLSLGNSEPWTKALENVVGARNMDVKPLLNYFQPLFDWLKEQNRNSFVGWNTEWSPYADQSIKVRISLKSALGANAYEWTNNEMFLFRSSVAYAMRKYFSIIKNQTVPFLEEDVRVSDLKPRVSFYFFVTSPQNVSDVIPRSEVEDAIRMSRGRINDVFGLNDNSLEFLGIHPTLEPPYQPPVTIWLIIFGVVMALVVVGIIILIVTGIKGRKKKNETKREENPYDSMDIGKGESNAGFQNSDDAQTSF

Target ORF information:

RefSeq Version	NM_001130513.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001130513.1

ORF Insert Sequence:

ATGTCCAGCT CCTCCTGGCT CCTTCTCAGC CTTGTTGCTG TTACTACTGC TCAGTCCCTC 
ACCGAGGAAA ATGCCAAGAC ATTTTTAAAC AACTTTAATC AGGAAGCTGA AGACCTGTCT 
TATCAAAGTT CACTTGCTTC TTGGAATTAT AATACTAACA TTACTGAAGA AAATGCCCAA 
AAGATGAGTG AGGCTGCAGC CAAATGGTCT GCCTTTTATG AAGAACAGTC TAAGACTGCC 
CAAAGTTTCT CACTACAAGA AATCCAGACT CCGATCATCA AGCGTCAACT ACAGGCCCTT 
CAGCAAAGTG GGTCTTCAGC ACTCTCAGCA GACAAGAACA AACAGTTGAA CACAATTCTG 
AACACCATGA GCACCATTTA CAGTACTGGA AAAGTTTGCA ACCCAAAGAA CCCACAAGAA 
TGCTTATTAC TTGAGCCAGG ATTGGATGAA ATAATGGCGA CAAGCACAGA CTACAACTCT 
AGGCTCTGGG CATGGGAGGG CTGGAGGGCT GAGGTTGGCA AGCAGCTGAG GCCGTTGTAT 
GAAGAGTATG TGGTCCTGAA AAACGAGATG GCAAGAGCAA ACAATTATAA CGACTATGGG 
GATTATTGGA GAGGGGACTA TGAAGCAGAG GGAGCAGATG GCTACAACTA TAACCGTAAC 
CAGTTGATTG AAGATGTAGA ACGTACCTTC GCAGAGATCA AGCCATTGTA TGAGCATCTT 
CATGCCTATG TGAGGAGGAA GTTGATGGAT ACCTACCCTT CCTACATCAG CCCCACTGGA 
TGCCTCCCTG CCCATTTGCT TGGTGATATG TGGGGTAGAT TTTGGACAAA TCTGTACCCT 
TTGACTGTTC CCTTTGCACA GAAACCAAAC ATAGATGTTA CTGATGCAAT GATGAATCAG 
GGCTGGGATG CAGAAAGGAT ATTTCAAGAG GCAGAGAAAT TCTTTGTTTC TGTTGGCCTT 
CCTCATATGA CTCAAGGATT CTGGGCAAAC TCTATGCTGA CTGAGCCAGC AGATGGCCGG 
AAAGTTGTCT GCCACCCCAC AGCTTGGGAT CTGGGACACG GAGACTTCAG AATCAAGATG 
TGTACAAAGG TCACAATGGA CAACTTCTTG ACAGCCCATC ACGAGATGGG ACACATCCAA 
TATGACATGG CATATGCCAG GCAACCTTTC CTGCTAAGAA ACGGAGCCAA TGAAGGGTTC 
CATGAAGCTG TTGGAGAAAT CATGTCACTT TCTGCAGCTA CCCCCAAGCA TCTGAAATCC 
ATTGGTCTTC TGCCATCCGA TTTTCAAGAA GATAGCGAAA CAGAGATAAA CTTCCTACTG 
AAACAGGCAT TGACAATTGT TGGAACACTA CCGTTTACTT ACATGTTAGA GAAGTGGAGG 
TGGATGGTCT TTCGGGGTGA AATTCCCAAA GAGCAGTGGA TGAAAAAGTG GTGGGAGATG 
AAGCGGGAGA TCGTTGGTGT GGTGGAGCCT CTGCCTCATG ATGAAACATA CTGTGACCCT 
GCATCTCTGT TCCATGTTTC TAATGATTAC TCATTCATTC GATATTACAC AAGGACCATT 
TACCAATTCC AGTTTCAAGA AGCTCTTTGT CAAGCAGCTA AGTATAATGG TTCTCTGCAC 
AAATGTGACA TCTCAAATTC CACTGAAGCT GGGCAGAAGT TGCTCAAGAT GCTGAGTCTT 
GGAAATTCAG AGCCCTGGAC CAAAGCCTTG GAAAATGTGG TAGGAGCAAG GAATATGGAT 
GTAAAACCAC TGCTCAATTA CTTCCAACCG TTGTTTGACT GGCTGAAAGA GCAGAACAGA 
AATTCTTTTG TGGGGTGGAA CACTGAATGG AGCCCATATG CCGACCAAAG CATTAAAGTG 
AGGATAAGCC TAAAATCAGC TCTTGGAGCT AATGCATATG AATGGACCAA CAACGAAATG 
TTCCTGTTCC GATCATCTGT TGCATATGCC ATGAGAAAGT ATTTTTCAAT AATCAAAAAC 
CAGACAGTTC CTTTTCTAGA GGAAGATGTA CGAGTGAGTG ATTTGAAACC AAGAGTCTCC 
TTCTACTTCT TTGTCACCTC ACCCCAAAAT GTGTCTGATG TCATTCCTAG AAGTGAAGTT 
GAAGATGCCA TCAGGATGTC TCGGGGCCGC ATCAATGATG TCTTTGGCCT GAATGATAAC 
AGCCTGGAGT TTCTGGGGAT TCACCCAACA CTTGAGCCAC CTTACCAGCC TCCTGTCACC 
ATATGGCTGA TTATTTTTGG TGTTGTGATG GCACTGGTAG TGGTTGGCAT CATCATCCTG 
ATTGTCACTG GGATCAAAGG TCGAAAGAAG AAAAATGAAA CAAAAAGAGA AGAGAACCCT 
TATGACTCGA TGGACATTGG AAAAGGAGAA AGCAATGCAG GATTCCAAAA CAGTGATGAT 
GCTCAGACTT CCTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice.
Journal of cachexia, sarcopenia and muscle9(5)975-986(2018 10)
Takeshita H,Yamamoto K,Nozato S,Takeda M,Fukada SI,Inagaki T,Tsuchimochi H,Shirai M,Nozato Y,Fujimoto T,Imaizumi Y,Yokoyama S,Nagasawa M,Hamano G,Hongyo K,Kawai T,Hanasaki-Yamamoto H,Takeda S,Takahashi T,Akasaka H,Itoh N,Takami Y,Takeya Y,Sugimoto K,Nakagami H,Rakugi H

Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response.
Cellular and molecular life sciences : CMLS75(19)3625-3634(2018 Oct)
Klempin F,Mosienko V,Matthes S,Villela DC,Todiras M,Penninger JM,Bader M,Santos RAS,Alenina N

Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction.
Stem cells (Dayton, Ohio)36(9)1430-1440(2018 09)
Duan Y,Beli E,Li Calzi S,Quigley JL,Miller RC,Moldovan L,Feng D,Salazar TE,Hazra S,Al-Sabah J,Chalam KV,Phuong Trinh TL,Meroueh M,Markel TA,Murray MC,Vyas RJ,Boulton ME,Parsons-Wingerter P,Oudit GY,Obukhov AG,Grant MB

Sex dimorphism in ANGII-mediated crosstalk between ACE2 and ACE in diabetic nephropathy.
Laboratory investigation; a journal of technical methods and pathology98(9)1237-1249(2018 09)
Clotet-Freixas S,Soler MJ,Palau V,Anguiano L,Gimeno J,Konvalinka A,Pascual J,Riera M

Sini decoction alleviates E. coli induced acute lung injury in mice via equilibrating ACE-AngII-AT1R and ACE2-Ang-(1-7)-Mas axis.
Life sciences208139-148(2018 Sep)
Liu J,Chen Q,Liu S,Yang X,Zhang Y,Huang F

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Ace2 cDNA ORF clone, Mus musculus(house mouse)

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