Notch2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Notch2
Entrez Gene ID	29492
Full Name	notch 2
General protein information	Preferred Names notch 2 Names neurogenic locus notch homolog protein 2 notch gene homolog 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34
Summary	transmembrane protein that may be involved in cellular interactions that specify cell fate [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_024358.2	NP_077334.2	neurogenic locus notch homolog protein 2 precursor

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	NOTCH2	XP_001114248.1
Rattus norvegicus (Norway rat)	Notch2	NP_077334.1
Homo sapiens (human)	NOTCH2	NP_077719.2
Canis lupus familiaris (dog)	NOTCH2	XP_005630745.1
Bos taurus (cattle)	NOTCH2	XP_002686160.2
Xenopus tropicalis (tropical clawed frog)	LOC100486344	XP_002939126.2
Pan troglodytes (chimpanzee)	NOTCH2	XP_513697.3
Mus musculus (house mouse)	Notch2	NP_035058.2
Gallus gallus (chicken)	NOTCH2	NP_001238962.1
Danio rerio (zebrafish)	notch2	NP_001108566.1

Gene Ontology
Bibliography

Related articles in PubMed

Hyperglycemia inhibits osteoblastogenesis of rat bone marrow stromal cells via activation of the Notch2 signaling pathway.
Huang KC, Chuang PY, Yang TY, Huang TW, Chang SF
International journal of medical sciences16(5)696-703(2019)

MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth.
Ho RX, Meyer RD, Chandler KB, Ersoy E, Park M, Bondzie PA, Rahimi N, Xu H, Costello CE, Rahimi N
Journal of molecular cell biology10(3)195-204(2018 06)

NOTCH2 Hajdu-Cheney Mutations Escape SCF
Fukushima H, Shimizu K, Watahiki A, Hoshikawa S, Kosho T, Oba D, Sakano S, Arakaki M, Yamada A, Nagashima K, Okabe K, Fukumoto S, Jimi E, Bigas A, Nakayama KI, Nakayama K, Aoki Y, Wei W, Inuzuka H
Molecular cell68(4)645-658.e5(2017 Nov)

Pattern of Notch2, Numb, and Cas8 Gene Expression in Relevant Structures of the Rat Brain during Formation of Spatial Memory.
Gruden' MA, Storozheva ZI, Ratmirov AM, Sherstnev VV
Bulletin of experimental biology and medicine163(6)785-788(2017 Oct)

The presence of VEGF and Notch2 during preantral-antral follicular transition in infantile rats: Anatomical evidence and its implications.
Torres-Ortiz MC, Gutiérrez-Ospina G, Gómez-Chavarín M, Murcia C, Alonso-Morales RA, Perera-Marín G
General and comparative endocrinology24982-92(2017 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Notch2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Notch2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa43292	NM_024358.2 Latest version!	Rattus norvegicus notch receptor 2 (Notch2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	29-31	$1301.30 $1859.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Notch2 ( NM_024358.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_077334.2 Rattus norvegicus notch receptor 2 (Notch2), mRNA.

Price & Availability↑

CloneID	ORa43292
Clone ID Related Accession (Same CDS sequence)	NM_024358.2
Accession Version	NM_024358.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 7416bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Rattus norvegicus(Norway rat)
Product	neurogenic locus notch homolog protein 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC129357.5. On Mar 11, 2015 this sequence version replaced NM_024358.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCGCTC TGCGTCCCGC CGCGCTGCGG GCGCTGCTGT GGCTCTGGCT GTGCGGCGCG 
GGCCCCGCGC ACGCTTTGCA GTGTCGAGGT GGTCAAGAGC CCTGTGTAAA TGAGGGGACC 
TGTGTTACCT ACCACAACGG CACAGGCTAC TGCCGATGTC CAGAGGGCTT CTTGGGAGAA 
TATTGTCAAC ATCGAGACCC TTGTGAGAAG AACCGCTGTC AGAATGGTGG TACTTGTGTG 
ACGCAGGCCA TGTTGGGAAA AGCCACCTGT CGATGTGCTC CAGGGTTCAC AGGGGAGGAC 
TGCCAATACT CGACCTCTCA CCCCTGTTTT GTTTCCCGCC CCTGTCAGAA TGGAGGTACC 
TGCCACATGC TCAGCTGGGA CACCTATGAG TGCACCTGTC AAGTTGGCTT CACAGGAAAG 
CAGTGTCAGT GGACAGATGT CTGTCTGTCT CATCCCTGTG AAAATGGAAG CACCTGTAGC 
TCTGTGGCCA ACCAGTTCTC CTGCAGATGT CCTGCAGGCA TCACAGGCCA GAAGTGTGAC 
GCCGACATCA ATGAATGTGA CATTCCAGGA CGCTGCCAAC ATGGAGGCAC CTGCCTCAAC 
CTTCCTGGGT CCTACCGATG CCAATGCCCT CAGGGCTTCA CAGGCCAGCA CTGTGACAGC 
CCGTACGTGC CCTGTGCACC CTCACCCTGC GTCAATGGAG GCACCTGCCG TCAGACTGGA 
GACTTCACTT CTGAATGCCA TTGCCTGCCA GGCTTTGAAG GGAGCAACTG CGAGCGGAAT 
ATCGACGACT GCCCTAACCA CAAGTGTCAG AATGGAGGGG TGTGTGTGGA TGGCGTCAAT 
ACTTACAACT GCCGCTGCCC CCCTCAGTGG ACTGGGCAGT TCTGCACAGA AGACGTGGAT 
GAGTGTCTGC TGCAGCCCAA TGCTTGTCAG AATGGAGGCA CTTGCACCAA CCGCAACGGA 
GGCTACGGCT GCGTGTGCGT GAACGGCTGG AGTGGGGATG ACTGCAGCGA GAACATCGAT 
GACTGTGCCT TCGCTTCCTG CACGCCAGGC TCCACCTGTA TTGACCGTGT GGCCTCCTTC 
TCCTGCCTTT GTCCAGAGGG AAAGGCAGGG CTCCTGTGTC ATCTGGATGA TGCCTGTATC 
AGCAACCCTT GTCACAAGGG GGCGCTGTGT GATACCAACC CCCTGAATGG GCAGTACATT 
TGCACCTGCC CACAGGGCTA CAAGGGCGCT GACTGCACAG AAGACGTGGA TGAGTGTGCT 
ATGGCCAACA GTAACCCTTG TGAGCATGCA GGAAAGTGTG TGAATACAGA TGGCGCCTTC 
CACTGCGAGT GTCTGAAGGG CTACGCAGGG CCTCGCTGTG AGATGGACAT CAACGAGTGT 
CACTCAGACC CCTGTCAGAA CGACGCCACC TGCCTGGATA AGATTGGAGG CTTCACCTGT 
CTCTGCATGC CGGGTTTCAA AGGTGTGCAT TGTGAACTGG AGGTGAATGA ATGCCAGAGC 
AACCCGTGTG TAAACAATGG GCAGTGTGTG GACAAAGTCA ATCGCTTCCA GTGTCTGTGT 
CCCCCTGGTT TCACAGGACC AGTGTGCCAG ATCGACATTG ACGACTGCTC CAGTACTCCC 
TGCCTGAATG GGGCCAAGTG CATCGATCAC CCGAATGGCT ATGAATGCCA GTGTGCCACA 
GGATTCACTG GCACACTGTG TGATGAGAAC ATCGACAACT GTGACCCGGA TCCTTGCCAC 
CATGGCCAGT GCCAGGATGG GATTGACTCC TACACCTGCA TCTGCAACCC CGGGTACATG 
GGAGCCATCT GTAGTGACCA GATTGATGAA TGCTACAGCA GCCCCTGCCT GAATGATGGA 
CGCTGCATCG ACCTGGTGAA CGGCTACCAG TGCAACTGCC AACCGGGTAC CTCAGGCCTT 
AATTGTGAAA TTAATTTTGA TGACTGTGCC AGCAACCCTT GTCTGCACGG AGCCTGTGTG 
GACGGCATCA ACCGTTACAG TTGTGTGTGC TCTCCGGGAT TCACAGGGCA GAGGTGCAAC 
ATAGACATTG ATGAGTGTGC CTCCAACCCC TGTCGCAAGG GTGCGACGTG CATCAATGAC 
GTGAATGGTT TCCGGTGTAT GTGCCCTGAG GGACCACACC ATCCCAGCTG CTACTCACAG 
GTGAACGAGT GTTTGAGCAG TCCCTGCATC CATGGAAACT GTACTGGAGG TCTCAGTGGC 
TATAAGTGCC TCTGCGATGC AGGCTGGGTT GGTATCAACT GCGAAGTGGA CAAAAATGAG 
TGTCTTTCTA ACCCGTGCCA GAATGGAGGG ACATGTAATA ACCTGGTGAA TGGCTACAGG 
TGTACATGCA AGAAGGGGTT CAAAGGCTAT AACTGCCAGG TGAACATAGA TGAGTGTGCC 
TCGAACCCGT GTCTGAACCA AGGGACCTGC CTCGATGACG TCAGTGGCTA CACCTGCCAC 
TGCATGCTGC CTTACACAGG CAAGAATTGT CAAACGGTGT TGGCGCCCTG CTCCCCTAAC 
CCGTGTGAGA ACGCTGCAGT TTGTAAAGAG GCACCCAACT TTGAGAGCTT CACCTGCCTG 
TGTGCCCCTG GCTGGCAAGG TCAGCGCTGT ACAGTTGACG TTGATGAGTG TGTCTCCAAG 
CCGTGTATGA ACAATGGCAT CTGCCATAAT ACTCAGGGCA GCTACATGTG CGAGTGCCCT 
CCCGGCTTCA GTGGTATGGA CTGTGAGGAG GACATCAATG ACTGCCTTGC CAACCCCTGC 
CAGAACGGAG GCTCCTGTGT GGACAAAGTG AACACCTTCT CCTGCCTGTG CCTTCCTGGC 
TTCGTAGGGG ACAAGTGCCA AACAGACATG AATGAATGTC TGAGCGAGCC CTGTAAGAAT 
GGGGGGACCT GCTCTGACTA CGTCAACAGC TACACCTGCA CGTGCCCTGC GGGCTTCCAT 
GGAGTCCACT GTGAAAACAA CATCGATGAG TGCACTGAGA GCTCCTGTTT CAATGGCGGC 
ACGTGTGTTG ATGGGATCAA CTCTTTCTCT TGCTTATGCC CTGTGGGTTT CACTGGTCCC 
TTCTGCCTCC ATGATATCAA TGAGTGCAGC TCTAACCCGT GCCTGAATTC GGGAACGTGT 
GTTGATGGCC TGGGTACCTA CCGATGCACC TGTCCCTTGG GCTACACTGG GAAAAACTGT 
CAGACCCTGG TGAACCTCTG CAGCCCCTCT CCATGTAAAA ACAAAGGAAC TTGTGCTCAG 
GAAAAGGCAA GGCCACGCTG CCTGTGTCCG CCTGGATGGG ATGGCGCATA CTGTGATGTG 
CTCAATGTGT CCTGTAAGGC GGCAGCCTTG CAGAAAGGAG TACCTGTTGA ACACTTGTGC 
CAGCACTCGG GTATCTGTAT CAATGCTGGC AACACGCATC ACTGCCAGTG CCCCCTGGGC 
TACACGGGGA GCTACTGCGA GGAACAGCTT GACGAGTGTG CGTCCAATCC ATGCCAGCAT 
GGTGCCACCT GCAGTGACTT CATCGGAGGA TACAGATGTG AGTGTGTTCC AGGGTATCAG 
GGTGTCAACT GTGAGTATGA AGTGGACGAG TGCCAGAACC AGCCCTGTCA GAACGGAGGC 
ACCTGCATCG ACCTCGTGAA CCATTTCAAG TGCTCGTGCC CACCAGGCAC CCGGGGCCTG 
CTTTGTGAAG AGAACATTGA TGACTGTGCT GGGGGCCCCC ACTGCCTTAA TGGTGGCCAG 
TGTGTGGACC GGATTGGAGG CTACAGTTGT CGCTGTTTGC CTGGCTTTGC TGGGGAGCGG 
TGTGAGGGGG ACATCAATGA ATGCCTGTCC AATCCTTGCA GCTCAGAGGG CAGCCTGGAC 
TGCATTCAGC TCAAAAATAA CTACCAGTGT GTCTGCCGCA GCGCCTTCAC AGGCCGACAC 
TGCGAAACCT TCCTAGATGT GTGTCCCCAG AAGCCTTGCC TGAATGGAGG GACTTGTGCT 
GTGGCTAGCA ACGTGCCTGA TGGCTTCATT TGTCGTTGTC CCCCAGGGTT CTCCGGGGCA 
AGATGCCAGA GCAGCTGTGG ACAAGTGAAG TGCAGAAGAG GGGAGCAGTG TGTGCACACC 
GCCTCGGGAC CCCACTGCTT CTGCCTGAAC CGCAAGGACT GCGAGTCAGG TTGCGCTAGT 
AACCCCTGCC AGCACGGAGG CACCTGCTAC CCTCAGCGCC AGCCTCCTTA CTACTCTTGC 
CGCTGCTCCC CACCGTTCTG GGGCAGCCAC TGCGAGAGCT ACACAGCCCC CACCAGCACC 
CCTCCTGCTA CCTGTCTGAG TCAGTACTGT GCCGACAAGG CTCGGGACGG CATCTGTGAT 
GAGGCCTGCA ACAGTCATGC CTGCCAGTGG GATGGAGGTG ACTGTTCCCT CACTATGGAG 
GACCCCTGGG CCAACTGCAC CTCCTCACTT CGCTGCTGGG AGTACATCAA CAACCAGTGT 
GATGAGCTGT GCAACACTGC AGAGTGCCTG TTTGACAACT TTGAATGCCA GAGGAATAGC 
AAAACCTGCA AGTATGACAA ATACTGTGCA GACCACTTCA AAGACAATCA CTGCGATAAG 
GGATGCAACA ACGAGGAGTG TGGCTGGGAC GGGCTGGACT GCGCTGCGGA CCAGCCTGAG 
AACCTGGCGG AGGGCATCCT GGTCATCGTG GTGCTCCTAC CCCCTGAGCA GCTGCTTCAG 
GATTCTCGAA GCTTCTTGAG GGCCCTGGGC ACCCTGCTCC ACACCAACTT ACGCATTAAA 
CAAGACTCTC AGGGCGCCCT CATGGTGTAC CCCTACTATG GGGAGAAGTC AGCTGCCATG 
AAGAAGCAGA AGGTGGCACG CAGGTCTCTT CCTGATGAGC AGGAACAGGA GATAATAGGC 
TCTAAGGTAT TTCTGGAAAT CGACAACCGA CAGTGTGTTC AAGACTCAGA CCAGTGCTTC 
AAGAACACAG ATGCTGCAGC TGCTCTCCTG GCTTCTCATG CCATCCAAGG GACCTTGTCC 
TACCCTCTGG TGTCTGTTGT CAGTGAATCG GAGGATCCAA GGAACACTCC GCTCCTCTAT 
CTGCTTGCGG TTGCTGTGGT CATTATCCTG TTCCTCATCC TGCTGGGGGT CATCATGGCA 
AAGCGGAAGC GCAAGCACGG CTTCCTCTGG CTGCCTGAAG GCTTCACGCT TCGCCGAGAC 
TCCAGCAATC ACAAGCGCCG TGAACCTGTG GGGCAGGATG CCGTGGGGCT GAAGAATCTC 
TCAGTGCAAG TGTCAGAGGC AAACCTGATC GGCTCCACGA CAAGCGAGCA TTGGGGTGAT 
GATGAAGGAC CCCAGCCAAA GAAAGCCAAG GCTGAGGACG ACGAGGCTTT GCTGTCGGAA 
GACGACCCTG TCGACCGGCG CCCCTGGACA CAGCAGCACC TTGAAGCTGC AGACATCCGC 
CGGACTCCAT CCCTGGCGCT CACCCCTCCT CAGGCAGAGC AGGAGGTGGA CGTGCTGGAC 
GTGAATGTCC GAGGCCCAGA TGGGTGCACC CCACTGATGC TGGCTTCTCT CCGAGGAGGC 
AGCTCAGACC TGAGTGATGA AGATGAAGAT GCTGAGGACT CTTCTGCCAA CATCATCACA 
GACTTGGTCT ACCAAGGTGC CAGCCTCCAG GCACAGACGG ACCGCACTGG TGAGATGGCC 
CTGCACCTTG CAGCCCGCTA TTCGAGAGCT GATGCTGCCA AACGCCTCCT GGATGCTGGT 
GCAGATGCCA ACGCCCAGGA CAACATGGGC CGCTGTCCTC TTCATGCTGC AGTTGCAGCG 
GATGCCCAAG GTGTCTTCCA GATTCTGATC CGCAACCGAG TAACGGATCT AGACGCCAGG 
ATGAATGATG GCACTACCCC CCTGATCCTG GCTGCCCGCC TGGCTGTGGA AGGAATGGTG 
GCAGAGCTGA TCAACTGCCA AGCAGATGTG AACGCAGTGG ATGACCATGG AAAATCTGCC 
CTCCACTGGG CAGCCGCCGT CAATAATGTG GAGGCAACTC TTTTGCTGTT GAAGAATGGG 
GCCAACCGGG ATATGCAGGA CAACAAGGAA GAGACACCTT TGTTTCTTGC TGCCCGAGAG 
GGAAGTTATG AAGCAGCCAA AATCCTGTTA GACCACTTTG CCAACCGGGA CATCACGGAC 
CACATGGACC GCCTTCCCCG GGATGTGGCT CGGGACCGCA TGCACCATGA CATAGTTCGC 
CTCCTGGACG AGTACAACGT GACTCCCAGC CCTCCGGGGA CTGTCTTGAC TTCTGCTCTC 
TCACCTGTCC TCTGTGGGCC CAACAGGTCT TTCCTCAGTC TGAAGCACAC CCCAATGGGT 
AAGAAGGCCA GACGGCCCAA CACCAAGAGC ACCATGCCCA CAAGCCTGCC TAACCTTGCC 
AAGGAGGCCA AGGACGTCAA GGGGAGCAGG AGGAAGAAGT GTCTCAACGA GAAGGTCCAG 
CTCTCCGAGA GCTCAGTGAC TTTATCCCCT GTCGACTCGC TCGAGTCTCC TCACACATAT 
GTTTCTGATG CCACGTCTTC CCCCATGATC ACGTCCCCTG GGATCTTACA GGCCTCACCC 
ACGCCTCTTC TGGCTGCTGC CCCAGCTGCC CCAGTGCATG CTCAGCATGC ACTGTCTTTC 
TCTAACCTTC ACGAAATGCA GCCTTTGGCT CCTGGAGCCA GCACCGTGCT CCCCTCAGTT 
AGCCAGTTGT TGTCCCACCA CCACATCGTC CCCCCAGGGA GTGGCAGTGC AGGAAGCTTG 
GGCAGGTTAC ATTCAGTCCC TGTCCCCTCA GACTGGATGA ACCGCGTGGA GATGAGTGAG 
ACCCAGTACA GTGAAATGTT TGGCATGGTC CTGGCTCCTG CAGAGGGAAC CCACCCTGGC 
ATGGCAGCTC CTCAGAGCAG AGCTCCGGAA GGGAAGCCCA TCCCCACACA GCGTGAGCCC 
TTGCCTCCCA TTGTAACTTT CCAGCTCATC CCGAAAGGCA GCCTTGCTCA AGCAGCTGGG 
GCTCCCCAGA CACAGTCCGG CTGCCCCCCA GCTGTGGCAG GCCCCTTGCC CTCTATGTAC 
CAGATCCCAG AGATGGCCCG TTTGCCCAGT GTGGCTTTCC CACCTACCAT GATGCCCCAG 
CAGGAGGGGC AGGTAGCTCA GACCATTGTC CCAACCTATC ACCCTTTCCC AGCCTCTGTG 
GGCAAGTACC CCACACCCCC TTCCCAACAC AGTTATGCCT CCTCAAATGC TGCCGAGCGC 
ACCCCCAATC ATGGTGGTCA CCTCCAGGGC GAGCACCCGT ACCTGACACC ATCCCCAGAG 
TCTCCTGACC AATGGTCGAG CTCTTCACCG CACTCTGCGT CTGACTGGTC AGATGTGACC 
ACCAGCCCAA CTCCTGGAGG GGGTGGAGGC GGTCAGCGGG GACCTGGAAC ACACATGTCC 
GAGCCACCAC ACAGCAACAT GCAGGTTTAT GCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077334.2
CDS	163..7578
Translation	MPALRPAALRALLWLWLCGAGPAHALQCRGGQEPCVNEGTCVTYHNGTGYCRCPEGFLGEYCQHRDPCEKNRCQNGGTCVTQAMLGKATCRCAPGFTGEDCQYSTSHPCFVSRPCQNGGTCHMLSWDTYECTCQVGFTGKQCQWTDVCLSHPCENGSTCSSVANQFSCRCPAGITGQKCDADINECDIPGRCQHGGTCLNLPGSYRCQCPQGFTGQHCDSPYVPCAPSPCVNGGTCRQTGDFTSECHCLPGFEGSNCERNIDDCPNHKCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCTNRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCLCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEVNECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGTLCDENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGLNCEINFDDCASNPCLHGACVDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINDVNGFRCMCPEGPHHPSCYSQVNECLSSPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCNNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCLDDVSGYTCHCMLPYTGKNCQTVLAPCSPNPCENAAVCKEAPNFESFTCLCAPGWQGQRCTVDVDECVSKPCMNNGICHNTQGSYMCECPPGFSGMDCEEDINDCLANPCQNGGSCVDKVNTFSCLCLPGFVGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCTCPAGFHGVHCENNIDECTESSCFNGGTCVDGINSFSCLCPVGFTGPFCLHDINECSSNPCLNSGTCVDGLGTYRCTCPLGYTGKNCQTLVNLCSPSPCKNKGTCAQEKARPRCLCPPGWDGAYCDVLNVSCKAAALQKGVPVEHLCQHSGICINAGNTHHCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCAGGPHCLNGGQCVDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLKNNYQCVCRSAFTGRHCETFLDVCPQKPCLNGGTCAVASNVPDGFICRCPPGFSGARCQSSCGQVKCRRGEQCVHTASGPHCFCLNRKDCESGCASNPCQHGGTCYPQRQPPYYSCRCSPPFWGSHCESYTAPTSTPPATCLSQYCADKARDGICDEACNSHACQWDGGDCSLTMEDPWANCTSSLRCWEYINNQCDELCNTAECLFDNFECQRNSKTCKYDKYCADHFKDNHCDKGCNNEECGWDGLDCAADQPENLAEGILVIVVLLPPEQLLQDSRSFLRALGTLLHTNLRIKQDSQGALMVYPYYGEKSAAMKKQKVARRSLPDEQEQEIIGSKVFLEIDNRQCVQDSDQCFKNTDAAAALLASHAIQGTLSYPLVSVVSESEDPRNTPLLYLLAVAVVIILFLILLGVIMAKRKRKHGFLWLPEGFTLRRDSSNHKRREPVGQDAVGLKNLSVQVSEANLIGSTTSEHWGDDEGPQPKKAKAEDDEALLSEDDPVDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVLCGPNRSFLSLKHTPMGKKARRPNTKSTMPTSLPNLAKEAKDVKGSRRKKCLNEKVQLSESSVTLSPVDSLESPHTYVSDATSSPMITSPGILQASPTPLLAAAPAAPVHAQHALSFSNLHEMQPLAPGASTVLPSVSQLLSHHHIVPPGSGSAGSLGRLHSVPVPSDWMNRVEMSETQYSEMFGMVLAPAEGTHPGMAAPQSRAPEGKPIPTQREPLPPIVTFQLIPKGSLAQAAGAPQTQSGCPPAVAGPLPSMYQIPEMARLPSVAFPPTMMPQQEGQVAQTIVPTYHPFPASVGKYPTPPSQHSYASSNAAERTPNHGGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGGGGGQRGPGTHMSEPPHSNMQVYA

Target ORF information:

RefSeq Version	NM_024358.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus notch receptor 2 (Notch2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024358.2

ORF Insert Sequence:

ATGCCCGCTC TGCGTCCCGC CGCGCTGCGG GCGCTGCTGT GGCTCTGGCT GTGCGGCGCG 
GGCCCCGCGC ACGCTTTGCA GTGTCGAGGT GGTCAAGAGC CCTGTGTAAA TGAGGGGACC 
TGTGTTACCT ACCACAACGG CACAGGCTAC TGCCGATGTC CAGAGGGCTT CTTGGGAGAA 
TATTGTCAAC ATCGAGACCC TTGTGAGAAG AACCGCTGTC AGAATGGTGG TACTTGTGTG 
ACGCAGGCCA TGTTGGGAAA AGCCACCTGT CGATGTGCTC CAGGGTTCAC AGGGGAGGAC 
TGCCAATACT CGACCTCTCA CCCCTGTTTT GTTTCCCGCC CCTGTCAGAA TGGAGGTACC 
TGCCACATGC TCAGCTGGGA CACCTATGAG TGCACCTGTC AAGTTGGCTT CACAGGAAAG 
CAGTGTCAGT GGACAGATGT CTGTCTGTCT CATCCCTGTG AAAATGGAAG CACCTGTAGC 
TCTGTGGCCA ACCAGTTCTC CTGCAGATGT CCTGCAGGCA TCACAGGCCA GAAGTGTGAC 
GCCGACATCA ATGAATGTGA CATTCCAGGA CGCTGCCAAC ATGGAGGCAC CTGCCTCAAC 
CTTCCTGGGT CCTACCGATG CCAATGCCCT CAGGGCTTCA CAGGCCAGCA CTGTGACAGC 
CCGTACGTGC CCTGTGCACC CTCACCCTGC GTCAATGGAG GCACCTGCCG TCAGACTGGA 
GACTTCACTT CTGAATGCCA TTGCCTGCCA GGCTTTGAAG GGAGCAACTG CGAGCGGAAT 
ATCGACGACT GCCCTAACCA CAAGTGTCAG AATGGAGGGG TGTGTGTGGA TGGCGTCAAT 
ACTTACAACT GCCGCTGCCC CCCTCAGTGG ACTGGGCAGT TCTGCACAGA AGACGTGGAT 
GAGTGTCTGC TGCAGCCCAA TGCTTGTCAG AATGGAGGCA CTTGCACCAA CCGCAACGGA 
GGCTACGGCT GCGTGTGCGT GAACGGCTGG AGTGGGGATG ACTGCAGCGA GAACATCGAT 
GACTGTGCCT TCGCTTCCTG CACGCCAGGC TCCACCTGTA TTGACCGTGT GGCCTCCTTC 
TCCTGCCTTT GTCCAGAGGG AAAGGCAGGG CTCCTGTGTC ATCTGGATGA TGCCTGTATC 
AGCAACCCTT GTCACAAGGG GGCGCTGTGT GATACCAACC CCCTGAATGG GCAGTACATT 
TGCACCTGCC CACAGGGCTA CAAGGGCGCT GACTGCACAG AAGACGTGGA TGAGTGTGCT 
ATGGCCAACA GTAACCCTTG TGAGCATGCA GGAAAGTGTG TGAATACAGA TGGCGCCTTC 
CACTGCGAGT GTCTGAAGGG CTACGCAGGG CCTCGCTGTG AGATGGACAT CAACGAGTGT 
CACTCAGACC CCTGTCAGAA CGACGCCACC TGCCTGGATA AGATTGGAGG CTTCACCTGT 
CTCTGCATGC CGGGTTTCAA AGGTGTGCAT TGTGAACTGG AGGTGAATGA ATGCCAGAGC 
AACCCGTGTG TAAACAATGG GCAGTGTGTG GACAAAGTCA ATCGCTTCCA GTGTCTGTGT 
CCCCCTGGTT TCACAGGACC AGTGTGCCAG ATCGACATTG ACGACTGCTC CAGTACTCCC 
TGCCTGAATG GGGCCAAGTG CATCGATCAC CCGAATGGCT ATGAATGCCA GTGTGCCACA 
GGATTCACTG GCACACTGTG TGATGAGAAC ATCGACAACT GTGACCCGGA TCCTTGCCAC 
CATGGCCAGT GCCAGGATGG GATTGACTCC TACACCTGCA TCTGCAACCC CGGGTACATG 
GGAGCCATCT GTAGTGACCA GATTGATGAA TGCTACAGCA GCCCCTGCCT GAATGATGGA 
CGCTGCATCG ACCTGGTGAA CGGCTACCAG TGCAACTGCC AACCGGGTAC CTCAGGCCTT 
AATTGTGAAA TTAATTTTGA TGACTGTGCC AGCAACCCTT GTCTGCACGG AGCCTGTGTG 
GACGGCATCA ACCGTTACAG TTGTGTGTGC TCTCCGGGAT TCACAGGGCA GAGGTGCAAC 
ATAGACATTG ATGAGTGTGC CTCCAACCCC TGTCGCAAGG GTGCGACGTG CATCAATGAC 
GTGAATGGTT TCCGGTGTAT GTGCCCTGAG GGACCACACC ATCCCAGCTG CTACTCACAG 
GTGAACGAGT GTTTGAGCAG TCCCTGCATC CATGGAAACT GTACTGGAGG TCTCAGTGGC 
TATAAGTGCC TCTGCGATGC AGGCTGGGTT GGTATCAACT GCGAAGTGGA CAAAAATGAG 
TGTCTTTCTA ACCCGTGCCA GAATGGAGGG ACATGTAATA ACCTGGTGAA TGGCTACAGG 
TGTACATGCA AGAAGGGGTT CAAAGGCTAT AACTGCCAGG TGAACATAGA TGAGTGTGCC 
TCGAACCCGT GTCTGAACCA AGGGACCTGC CTCGATGACG TCAGTGGCTA CACCTGCCAC 
TGCATGCTGC CTTACACAGG CAAGAATTGT CAAACGGTGT TGGCGCCCTG CTCCCCTAAC 
CCGTGTGAGA ACGCTGCAGT TTGTAAAGAG GCACCCAACT TTGAGAGCTT CACCTGCCTG 
TGTGCCCCTG GCTGGCAAGG TCAGCGCTGT ACAGTTGACG TTGATGAGTG TGTCTCCAAG 
CCGTGTATGA ACAATGGCAT CTGCCATAAT ACTCAGGGCA GCTACATGTG CGAGTGCCCT 
CCCGGCTTCA GTGGTATGGA CTGTGAGGAG GACATCAATG ACTGCCTTGC CAACCCCTGC 
CAGAACGGAG GCTCCTGTGT GGACAAAGTG AACACCTTCT CCTGCCTGTG CCTTCCTGGC 
TTCGTAGGGG ACAAGTGCCA AACAGACATG AATGAATGTC TGAGCGAGCC CTGTAAGAAT 
GGGGGGACCT GCTCTGACTA CGTCAACAGC TACACCTGCA CGTGCCCTGC GGGCTTCCAT 
GGAGTCCACT GTGAAAACAA CATCGATGAG TGCACTGAGA GCTCCTGTTT CAATGGCGGC 
ACGTGTGTTG ATGGGATCAA CTCTTTCTCT TGCTTATGCC CTGTGGGTTT CACTGGTCCC 
TTCTGCCTCC ATGATATCAA TGAGTGCAGC TCTAACCCGT GCCTGAATTC GGGAACGTGT 
GTTGATGGCC TGGGTACCTA CCGATGCACC TGTCCCTTGG GCTACACTGG GAAAAACTGT 
CAGACCCTGG TGAACCTCTG CAGCCCCTCT CCATGTAAAA ACAAAGGAAC TTGTGCTCAG 
GAAAAGGCAA GGCCACGCTG CCTGTGTCCG CCTGGATGGG ATGGCGCATA CTGTGATGTG 
CTCAATGTGT CCTGTAAGGC GGCAGCCTTG CAGAAAGGAG TACCTGTTGA ACACTTGTGC 
CAGCACTCGG GTATCTGTAT CAATGCTGGC AACACGCATC ACTGCCAGTG CCCCCTGGGC 
TACACGGGGA GCTACTGCGA GGAACAGCTT GACGAGTGTG CGTCCAATCC ATGCCAGCAT 
GGTGCCACCT GCAGTGACTT CATCGGAGGA TACAGATGTG AGTGTGTTCC AGGGTATCAG 
GGTGTCAACT GTGAGTATGA AGTGGACGAG TGCCAGAACC AGCCCTGTCA GAACGGAGGC 
ACCTGCATCG ACCTCGTGAA CCATTTCAAG TGCTCGTGCC CACCAGGCAC CCGGGGCCTG 
CTTTGTGAAG AGAACATTGA TGACTGTGCT GGGGGCCCCC ACTGCCTTAA TGGTGGCCAG 
TGTGTGGACC GGATTGGAGG CTACAGTTGT CGCTGTTTGC CTGGCTTTGC TGGGGAGCGG 
TGTGAGGGGG ACATCAATGA ATGCCTGTCC AATCCTTGCA GCTCAGAGGG CAGCCTGGAC 
TGCATTCAGC TCAAAAATAA CTACCAGTGT GTCTGCCGCA GCGCCTTCAC AGGCCGACAC 
TGCGAAACCT TCCTAGATGT GTGTCCCCAG AAGCCTTGCC TGAATGGAGG GACTTGTGCT 
GTGGCTAGCA ACGTGCCTGA TGGCTTCATT TGTCGTTGTC CCCCAGGGTT CTCCGGGGCA 
AGATGCCAGA GCAGCTGTGG ACAAGTGAAG TGCAGAAGAG GGGAGCAGTG TGTGCACACC 
GCCTCGGGAC CCCACTGCTT CTGCCTGAAC CGCAAGGACT GCGAGTCAGG TTGCGCTAGT 
AACCCCTGCC AGCACGGAGG CACCTGCTAC CCTCAGCGCC AGCCTCCTTA CTACTCTTGC 
CGCTGCTCCC CACCGTTCTG GGGCAGCCAC TGCGAGAGCT ACACAGCCCC CACCAGCACC 
CCTCCTGCTA CCTGTCTGAG TCAGTACTGT GCCGACAAGG CTCGGGACGG CATCTGTGAT 
GAGGCCTGCA ACAGTCATGC CTGCCAGTGG GATGGAGGTG ACTGTTCCCT CACTATGGAG 
GACCCCTGGG CCAACTGCAC CTCCTCACTT CGCTGCTGGG AGTACATCAA CAACCAGTGT 
GATGAGCTGT GCAACACTGC AGAGTGCCTG TTTGACAACT TTGAATGCCA GAGGAATAGC 
AAAACCTGCA AGTATGACAA ATACTGTGCA GACCACTTCA AAGACAATCA CTGCGATAAG 
GGATGCAACA ACGAGGAGTG TGGCTGGGAC GGGCTGGACT GCGCTGCGGA CCAGCCTGAG 
AACCTGGCGG AGGGCATCCT GGTCATCGTG GTGCTCCTAC CCCCTGAGCA GCTGCTTCAG 
GATTCTCGAA GCTTCTTGAG GGCCCTGGGC ACCCTGCTCC ACACCAACTT ACGCATTAAA 
CAAGACTCTC AGGGCGCCCT CATGGTGTAC CCCTACTATG GGGAGAAGTC AGCTGCCATG 
AAGAAGCAGA AGGTGGCACG CAGGTCTCTT CCTGATGAGC AGGAACAGGA GATAATAGGC 
TCTAAGGTAT TTCTGGAAAT CGACAACCGA CAGTGTGTTC AAGACTCAGA CCAGTGCTTC 
AAGAACACAG ATGCTGCAGC TGCTCTCCTG GCTTCTCATG CCATCCAAGG GACCTTGTCC 
TACCCTCTGG TGTCTGTTGT CAGTGAATCG GAGGATCCAA GGAACACTCC GCTCCTCTAT 
CTGCTTGCGG TTGCTGTGGT CATTATCCTG TTCCTCATCC TGCTGGGGGT CATCATGGCA 
AAGCGGAAGC GCAAGCACGG CTTCCTCTGG CTGCCTGAAG GCTTCACGCT TCGCCGAGAC 
TCCAGCAATC ACAAGCGCCG TGAACCTGTG GGGCAGGATG CCGTGGGGCT GAAGAATCTC 
TCAGTGCAAG TGTCAGAGGC AAACCTGATC GGCTCCACGA CAAGCGAGCA TTGGGGTGAT 
GATGAAGGAC CCCAGCCAAA GAAAGCCAAG GCTGAGGACG ACGAGGCTTT GCTGTCGGAA 
GACGACCCTG TCGACCGGCG CCCCTGGACA CAGCAGCACC TTGAAGCTGC AGACATCCGC 
CGGACTCCAT CCCTGGCGCT CACCCCTCCT CAGGCAGAGC AGGAGGTGGA CGTGCTGGAC 
GTGAATGTCC GAGGCCCAGA TGGGTGCACC CCACTGATGC TGGCTTCTCT CCGAGGAGGC 
AGCTCAGACC TGAGTGATGA AGATGAAGAT GCTGAGGACT CTTCTGCCAA CATCATCACA 
GACTTGGTCT ACCAAGGTGC CAGCCTCCAG GCACAGACGG ACCGCACTGG TGAGATGGCC 
CTGCACCTTG CAGCCCGCTA TTCGAGAGCT GATGCTGCCA AACGCCTCCT GGATGCTGGT 
GCAGATGCCA ACGCCCAGGA CAACATGGGC CGCTGTCCTC TTCATGCTGC AGTTGCAGCG 
GATGCCCAAG GTGTCTTCCA GATTCTGATC CGCAACCGAG TAACGGATCT AGACGCCAGG 
ATGAATGATG GCACTACCCC CCTGATCCTG GCTGCCCGCC TGGCTGTGGA AGGAATGGTG 
GCAGAGCTGA TCAACTGCCA AGCAGATGTG AACGCAGTGG ATGACCATGG AAAATCTGCC 
CTCCACTGGG CAGCCGCCGT CAATAATGTG GAGGCAACTC TTTTGCTGTT GAAGAATGGG 
GCCAACCGGG ATATGCAGGA CAACAAGGAA GAGACACCTT TGTTTCTTGC TGCCCGAGAG 
GGAAGTTATG AAGCAGCCAA AATCCTGTTA GACCACTTTG CCAACCGGGA CATCACGGAC 
CACATGGACC GCCTTCCCCG GGATGTGGCT CGGGACCGCA TGCACCATGA CATAGTTCGC 
CTCCTGGACG AGTACAACGT GACTCCCAGC CCTCCGGGGA CTGTCTTGAC TTCTGCTCTC 
TCACCTGTCC TCTGTGGGCC CAACAGGTCT TTCCTCAGTC TGAAGCACAC CCCAATGGGT 
AAGAAGGCCA GACGGCCCAA CACCAAGAGC ACCATGCCCA CAAGCCTGCC TAACCTTGCC 
AAGGAGGCCA AGGACGTCAA GGGGAGCAGG AGGAAGAAGT GTCTCAACGA GAAGGTCCAG 
CTCTCCGAGA GCTCAGTGAC TTTATCCCCT GTCGACTCGC TCGAGTCTCC TCACACATAT 
GTTTCTGATG CCACGTCTTC CCCCATGATC ACGTCCCCTG GGATCTTACA GGCCTCACCC 
ACGCCTCTTC TGGCTGCTGC CCCAGCTGCC CCAGTGCATG CTCAGCATGC ACTGTCTTTC 
TCTAACCTTC ACGAAATGCA GCCTTTGGCT CCTGGAGCCA GCACCGTGCT CCCCTCAGTT 
AGCCAGTTGT TGTCCCACCA CCACATCGTC CCCCCAGGGA GTGGCAGTGC AGGAAGCTTG 
GGCAGGTTAC ATTCAGTCCC TGTCCCCTCA GACTGGATGA ACCGCGTGGA GATGAGTGAG 
ACCCAGTACA GTGAAATGTT TGGCATGGTC CTGGCTCCTG CAGAGGGAAC CCACCCTGGC 
ATGGCAGCTC CTCAGAGCAG AGCTCCGGAA GGGAAGCCCA TCCCCACACA GCGTGAGCCC 
TTGCCTCCCA TTGTAACTTT CCAGCTCATC CCGAAAGGCA GCCTTGCTCA AGCAGCTGGG 
GCTCCCCAGA CACAGTCCGG CTGCCCCCCA GCTGTGGCAG GCCCCTTGCC CTCTATGTAC 
CAGATCCCAG AGATGGCCCG TTTGCCCAGT GTGGCTTTCC CACCTACCAT GATGCCCCAG 
CAGGAGGGGC AGGTAGCTCA GACCATTGTC CCAACCTATC ACCCTTTCCC AGCCTCTGTG 
GGCAAGTACC CCACACCCCC TTCCCAACAC AGTTATGCCT CCTCAAATGC TGCCGAGCGC 
ACCCCCAATC ATGGTGGTCA CCTCCAGGGC GAGCACCCGT ACCTGACACC ATCCCCAGAG 
TCTCCTGACC AATGGTCGAG CTCTTCACCG CACTCTGCGT CTGACTGGTC AGATGTGACC 
ACCAGCCCAA CTCCTGGAGG GGGTGGAGGC GGTCAGCGGG GACCTGGAAC ACACATGTCC 
GAGCCACCAC ACAGCAACAT GCAGGTTTAT GCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hyperglycemia inhibits osteoblastogenesis of rat bone marrow stromal cells via activation of the Notch2 signaling pathway.
International journal of medical sciences16(5)696-703(2019)
Huang KC,Chuang PY,Yang TY,Huang TW,Chang SF

MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth.
Journal of molecular cell biology10(3)195-204(2018 06)
Ho RX,Meyer RD,Chandler KB,Ersoy E,Park M,Bondzie PA,Rahimi N,Xu H,Costello CE,Rahimi N

NOTCH2 Hajdu-Cheney Mutations Escape SCF
Molecular cell68(4)645-658.e5(2017 Nov)
Fukushima H,Shimizu K,Watahiki A,Hoshikawa S,Kosho T,Oba D,Sakano S,Arakaki M,Yamada A,Nagashima K,Okabe K,Fukumoto S,Jimi E,Bigas A,Nakayama KI,Nakayama K,Aoki Y,Wei W,Inuzuka H

Pattern of Notch2, Numb, and Cas8 Gene Expression in Relevant Structures of the Rat Brain during Formation of Spatial Memory.
Bulletin of experimental biology and medicine163(6)785-788(2017 Oct)
Gruden' MA,Storozheva ZI,Ratmirov AM,Sherstnev VV

The presence of VEGF and Notch2 during preantral-antral follicular transition in infantile rats: Anatomical evidence and its implications.
General and comparative endocrinology24982-92(2017 08)
Torres-Ortiz MC,Gutiérrez-Ospina G,Gómez-Chavarín M,Murcia C,Alonso-Morales RA,Perera-Marín G

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Notch2 cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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