Notch2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Notch2
Entrez Gene ID	18129
Full Name	notch 2
Synonyms	AI853703,N2
General protein information	Preferred Names notch 2 Names neurogenic locus notch homolog protein 2 Motch B Notch gene homolog 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3 F2.2\|3 42.42 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010928.2	NP_035058.2	neurogenic locus notch homolog protein 2 precursor

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	NOTCH2	XP_001114248.1
Rattus norvegicus (Norway rat)	Notch2	NP_077334.1
Homo sapiens (human)	NOTCH2	NP_077719.2
Canis lupus familiaris (dog)	NOTCH2	XP_005630745.1
Bos taurus (cattle)	NOTCH2	XP_002686160.2
Xenopus tropicalis (tropical clawed frog)	LOC100486344	XP_002939126.2
Pan troglodytes (chimpanzee)	NOTCH2	XP_513697.3
Mus musculus (house mouse)	Notch2	NP_035058.2
Gallus gallus (chicken)	NOTCH2	NP_001238962.1
Danio rerio (zebrafish)	notch2	NP_001108566.1

Gene Ontology
Bibliography

Related articles in PubMed

Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.
Telley L, Agirman G, Prados J, Amberg N, Fièvre S, Oberst P, Bartolini G, Vitali I, Cadilhac C, Hippenmeyer S, Nguyen L, Dayer A, Jabaudon D
Science (New York, N.Y.)364(6440)(2019 05)

Constitutive activation of Notch2 signalling confers chemoresistance to neural stem cells via transactivation of fibroblast growth factor receptor-1.
Tomé M, Tchorz J, Gassmann M, Bettler B
Stem cell research35101390(2019 03)

Mature IgD
Ray A, Khalil MI, Pulakanti KL, Burns RT, Gurski CJ, Basu S, Wang D, Rao S, Dittel BN
Nature communications10(1)190(2019 01)

miR-181b/Notch2 overcome chemoresistance by regulating cancer stem cell-like properties in NSCLC.
Wang X, Meng Q, Qiao W, Ma R, Ju W, Hu J, Lu H, Cui J, Jin Z, Zhao Y, Wang Y
Stem cell research & therapy9(1)327(2018 11)

A perivascular niche for multipotent progenitors in the fetal testis.
Kumar DL, DeFalco T
Nature communications9(1)4519(2018 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Notch2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Notch2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21653	NM_010928.2 Latest version!	Mus musculus notch 2 (Notch2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	29-31	$1301.30 $1859.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Notch2 ( NM_010928.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035058.2 Mus musculus notch 2 (Notch2), mRNA.

Price & Availability↑

CloneID	OMu21653
Clone ID Related Accession (Same CDS sequence)	NM_010928.2
Accession Version	NM_010928.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 7422bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Mus musculus(house mouse)
Product	neurogenic locus notch homolog protein 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from D32210.1, AC164091.3 and AC154173.3. On Mar 30, 2007 this sequence version replaced NM_010928.1. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D32210.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCCCGCTC TGCGTCCCGC CGCGCTGCGG GCGCTGCTGT GGCTCTGGCT GTGCGGCGCG 
GGCCCCGCGC ACGCTTTGCA GTGTCGAGGT GGTCAAGAGC CCTGTGTAAA TGAAGGGACC 
TGTGTTACCT ACCACAACGG CACAGGCTTC TGCCGATGTC CAGAGGGCTT CTTGGGAGAA 
TATTGCCAAC ATCGAGACCC CTGTGAGAAA AACCGCTGTC AGAATGGTGG TACTTGTGTG 
CCGCAGGGCA TGTTGGGGAA AGCTACCTGC CGATGTGCTC CAGGATTCAC AGGAGAGGAC 
TGCCAATACT CCACCTCTCA CCCCTGCTTT GTGTCCCGCC CTTGTCAGAA TGGGGGTACC 
TGTCACATGC TCAGCCGGGA CACCTACGAG TGCACCTGCC AAGTCGGCTT CACAGGGAAG 
CAGTGTCAGT GGACAGATGC CTGTCTATCT CATCCCTGCG AAAATGGAAG CACCTGTACA 
TCTGTGGCCA GCCAGTTCTC CTGCAAATGC CCTGCAGGCC TCACAGGGCA GAAGTGTGAA 
GCTGATATCA ATGAGTGTGA CATTCCAGGA CGCTGCCAAC ATGGTGGCAC CTGCCTCAAC 
CTTCCTGGTT CCTACAGATG CCAATGTCCT CAGGGCTTCA CAGGCCAGCA CTGTGACAGC 
CCTTATGTGC CCTGTGCACC CTCGCCCTGC GTCAACGGAG GCACCTGTCG TCAGACTGGC 
GACTTCACTT TCGAATGCAA CTGCCTGCCA GGTTTTGAAG GGAGCACCTG TGAGCGGAAT 
ATCGACGACT GCCCCAACCA CAAGTGTCAG AATGGAGGAG TTTGTGTGGA TGGTGTCAAT 
ACCTACAATT GCCGCTGTCC CCCTCAGTGG ACTGGGCAGT TCTGCACAGA AGATGTGGAC 
GAGTGTCTGT TGCAGCCCAA CGCTTGTCAG AATGGAGGCA CCTGCACCAA CCGAAACGGA 
GGCTATGGCT GCGTGTGTGT GAACGGCTGG AGCGGAGATG ACTGCAGCGA GAATATCGAT 
GACTGTGCCT ATGCTTCCTG CACGCCAGGG TCCACCTGCA TTGACCGCGT GGCCTCCTTC 
TCCTGCCTGT GTCCGGAGGG AAAGGCGGGT CTCCTGTGCC ATCTGGATGA TGCCTGTATC 
AGCAACCCTT GTCACAAGGG GGCGCTGTGT GACACCAACC CCCTGAACGG GCAGTACATT 
TGCACCTGCC CACAGGGCTA CAAGGGCGCT GACTGCACAG AAGACGTGGA TGAGTGTGCT 
ATGGCCAACA GTAACCCTTG TGAGCATGCA GGAAAGTGTG TGAATACAGA TGGCGCCTTC 
CACTGTGAGT GTCTGAAGGG CTACGCAGGG CCTCGCTGTG AGATGGACAT CAACGAGTGT 
CATTCAGACC CCTGCCAGAA CGACGCCACC TGCCTGGATA AGATCGGAGG CTTCACCTGT 
CTGTGCATGC CAGGTTTCAA AGGTGTGCAT TGTGAGCTGG AGGTAAATGA ATGCCAGAGC 
AACCCGTGTG TGAACAACGG GCAGTGTGTG GACAAAGTCA ACCGCTTCCA GTGTCTGTGT 
CCCCCTGGCT TCACAGGACC AGTGTGCCAG ATCGACATTG ATGACTGCTC CAGTACTCCC 
TGCCTGAATG GGGCCAAGTG CATCGATCAC CCGAATGGCT ATGAATGCCA GTGTGCCACA 
GGTTTCACTG GCATATTGTG TGATGAGAAC ATCGACAACT GTGACCCAGA TCCTTGCCAC 
CATGGCCAGT GCCAGGATGG GATCGACTCC TACACCTGCA TCTGCAACCC TGGGTACATG 
GGAGCCATCT GTAGTGACCA GATTGATGAA TGCTACAGCA GCCCTTGCTT GAACGATGGG 
CGCTGCATTG ACCTGGTGAA TGGTTACCAG TGCAACTGCC AACCAGGCAC ATCAGGCCTT 
AATTGTGAAA TTAATTTTGA TGACTGTGCC AGCAACCCTT GTATGCACGG AGTCTGTGTG 
GACGGCATCA ATCGCTACAG CTGTGTGTGC TCTCCGGGAT TCACAGGCCA GAGGTGCAAT 
ATTGACATTG ATGAGTGTGC CTCCAACCCC TGTCGCAAGG GTGCGACGTG CATCAATGAT 
GTGAATGGTT TCCGGTGTAT ATGCCCCGAG GGACCGCATC ATCCTAGCTG CTACTCACAG 
GTGAACGAGT GCCTGAGCAA TCCCTGCATC CACGGAAACT GTACTGGAGG TCTCAGTGGC 
TATAAGTGCC TCTGCGATGC AGGCTGGGTT GGTGTCAACT GTGAGGTGGA CAAAAATGAG 
TGTCTTTCTA ACCCATGCCA GAATGGAGGA ACGTGCAATA ACCTGGTGAA TGGCTACAGG 
TGTACCTGCA AGAAGGGGTT CAAAGGCTAC AACTGCCAGG TGAATATAGA TGAGTGTGCC 
TCCAACCCGT GTCTGAACCA AGGAACCTGC TTTGATGACG TCAGTGGCTA CACTTGCCAC 
TGCATGTTGC CTTACACAGG CAAGAACTGT CAAACAGTGT TGGCTCCCTG TTCCCCAAAC 
CCGTGTGAGA ATGCTGCTGT TTGTAAAGAG GCACCCAATT TTGAGAGCTT CAGCTGCTTG 
TGTGCTCCTG GCTGGCAAGG TAAACGATGT ACAGTTGACG TTGATGAGTG TATCTCCAAG 
CCGTGTATGA ACAATGGTGT CTGCCACAAC ACTCAGGGCA GCTACGTGTG TGAGTGTCCT 
CCCGGCTTCA GTGGGATGGA CTGTGAAGAG GACATCAATG ATTGCCTTGC CAACCCCTGC 
CAGAACGGAG GCTCCTGTGT GGACCATGTG AATACCTTCT CCTGCCAGTG CCATCCTGGC 
TTCATAGGGG ACAAGTGCCA GACAGACATG AATGAGTGTC TGAGCGAGCC CTGTAAGAAT 
GGGGGGACCT GCTCCGACTA TGTCAACAGT TACACCTGCA CATGCCCTGC GGGCTTCCAC 
GGAGTCCACT GTGAAAACAA CATTGACGAG TGCACTGAGA GCTCCTGCTT CAATGGCGGC 
ACGTGTGTTG ATGGAATCAA CTCTTTCTCT TGCTTGTGCC CCGTGGGTTT CACTGGTCCC 
TTCTGCCTCC ATGATATCAA TGAGTGCAGC TCTAACCCGT GCCTGAATGC TGGAACGTGT 
GTTGATGGTC TGGGTACCTA CCGATGCATC TGTCCCTTGG GCTACACCGG GAAAAACTGT 
CAGACCCTGG TGAACCTCTG CAGCCGGTCT CCGTGTAAAA ACAAAGGAAC TTGTGTTCAG 
GAAAAGGCAA GGCCCCACTG TCTGTGTCCG CCTGGATGGG ATGGTGCATA CTGTGATGTG 
CTCAACGTGT CCTGTAAGGC GGCAGCCTTG CAGAAAGGAG TACCTGTTGA ACACTTGTGC 
CAGCACTCGG GCATCTGTAT CAATGCTGGC AACACCCATC ACTGCCAGTG CCCCCTGGGC 
TACACGGGGA GCTACTGCGA GGAGCAGCTT GATGAGTGTG CATCCAATCC ATGCCAGCAC 
GGTGCCACCT GCAATGACTT CATCGGAGGA TACAGATGTG AGTGTGTTCC AGGATATCAG 
GGTGTCAACT GTGAGTATGA AGTGGACGAG TGCCAGAACC AACCCTGCCA GAATGGAGGC 
ACCTGCATCG ACCTTGTGAA CCATTTCAAG TGTTCGTGTC CCCCAGGCAC CCGGGGCCTG 
CTGTGTGAAG AGAACATCGA TGAATGTGCT GGGGGCCCCC ACTGCCTTAA CGGTGGCCAG 
TGCGTGGACC GGATTGGAGG CTACACTTGT CGCTGTTTGC CTGGCTTTGC TGGGGAGCGG 
TGTGAGGGGG ACATCAACGA ATGCCTGTCC AACCCTTGCA GCTCAGAGGG CAGCCTGGAC 
TGCGTTCAGC TCAAAAATAA CTACAACTGT ATCTGCCGCA GCGCCTTCAC GGGCCGGCAC 
TGTGAAACCT TCCTAGATGT GTGTCCCCAG AAGCCTTGCC TGAACGGAGG GACTTGTGCC 
GTGGCTAGCA ACATGCCCGA TGGCTTCATC TGTCGTTGTC CCCCAGGGTT CTCTGGGGCG 
AGATGCCAGA GCAGCTGTGG ACAAGTGAAG TGCAGGAGAG GGGAGCAGTG TATCCACACT 
GACTCGGGAC CTCGCTGCTT CTGCCTGAAC CCCAAGGACT GCGAGTCAGG ATGTGCCAGT 
AACCCCTGCC AGCATGGGGG CACCTGCTAT CCTCAGCGCC AGCCTCCTCA CTATTCCTGC 
CGCTGCCCTC CGTCGTTCGG GGGCAGCCAC TGCGAACTCT ACACAGCCCC CACCAGCACC 
CCTCCTGCTA CCTGTCAGAG TCAGTACTGC GCCGACAAGG CTCGGGATGG CATCTGTGAC 
GAGGCCTGCA ATAGTCATGC CTGCCAGTGG GATGGAGGTG ACTGTTCCCT CACTATGGAG 
GACCCCTGGG CCAACTGCAC CTCCACTCTT CGCTGCTGGG AATACATCAA CAACCAGTGT 
GATGAGCAGT GCAACACCGC AGAGTGCCTG TTTGACAACT TTGAGTGCCA GAGGAATAGC 
AAGACGTGCA AGTATGACAA ATACTGTGCA GACCACTTCA AAGACAACCA CTGTGATCAG 
GGATGCAACA GCGAGGAGTG TGGCTGGGAT GGGCTGGACT GCGCTTCGGA CCAGCCTGAG 
AACCTGGCAG AGGGCACCCT GATCATCGTG GTGCTCCTGC CCCCTGAACA GCTGCTGCAG 
GATTCGCGAA GCTTCTTGAG GGCCCTGGGC ACCCTGCTCC ACACCAACTT GCGCATTAAA 
CAAGATTCTC AGGGCGCTCT CATGGTGTAC CCCTACTTTG GGGAGAAGTC AGCTGCCATG 
AAGAAGCAGA AGATGACACG CAGGTCTCTT CCTGAGGAGC AGGAGCAGGA GCAGGAGGTG 
ATAGGCTCTA AGATATTTCT GGAGATCGAC AACCGACAGT GTGTTCAAGA TTCAGACCAG 
TGCTTCAAAA ACACAGATGC GGCAGCTGCT CTCCTGGCTT CTCATGCCAT CCAAGGGACC 
CTATCCTACC CTCTAGTGTC TGTTTTCAGT GAACTGGAGA GTCCAAGAAA CGCCCAGCTT 
CTCTATCTGC TCGCGGTCGC TGTTGTCATC ATCCTGTTCT TCATCCTGCT GGGGGTCATC 
ATGGCCAAGC GGAAGCGCAA GCATGGCTTC CTCTGGCTGC CGGAAGGGTT CACCCTCCGC 
CGAGACTCTA GCAATCACAA GCGCCGTGAA CCTGTGGGAC AGGATGCCGT GGGGCTGAAA 
AATCTCTCCG TGCAAGTGTC AGAGGCTAAC CTGATTGGTT CTGGGACAAG TGAACATTGG 
GTTGATGATG AAGGACCCCA GCCAAAGAAA GCCAAGGCTG AGGATGAGGC TTTGCTGTCG 
GAAGATGACC CCATCGATCG ACGGCCCTGG ACACAGCAGC ACCTTGAAGC TGCAGACATC 
CGCCACACTC CATCCCTGGC ACTCACTCCT CCTCAGGCAG AACAGGAGGT GGACGTGCTG 
GACGTGAATG TCCGAGGCCC AGATGGGTGT ACTCCACTGA TGCTGGCTTC TCTCCGAGGA 
GGCAGCTCAG ACCTGAGTGA TGAAGACGAA GATGCTGAGG ACTCTTCTGC CAACATCATC 
ACAGACTTGG TCTACCAAGG TGCCAGCCTT CAAGCACAGA CAGACCGCAC TGGCGAGATG 
GCCCTGCACC TTGCAGCCCG CTATTCGAGA GCTGATGCTG CCAAACGCCT CCTGGATGCT 
GGTGCGGATG CAAATGCCCA GGACAACATG GGCCGATGTC CTCTTCACGC TGCGGTGGCA 
GCAGACGCCC AAGGTGTCTT TCAGATTCTG ATCCGCAACC GTGTAACCGA TCTGGATGCC 
AGAATGAACG ATGGTACTAC CCCCCTGATC CTGGCTGCCC GCCTGGCTGT GGAAGGAATG 
GTGGCAGAGT TGATCAATTG CCAAGCAGAT GTCAATGCAG TGGATGACCA TGGAAAATCT 
GCCCTCCACT GGGCAGCTGC TGTCAATAAT GTGGAGGCGA CTCTTCTGCT GTTGAAGAAT 
GGGGCCAACA GAGATATGCA GGACAATAAG GAAGAGACAC CTTTGTTTCT TGCTGCCCGA 
GAGGGAAGTT ATGAAGCGGC CAAAATCCTG TTAGACCATT TTGCCAACCG GGACATCACT 
GACCACATGG ACCGCCTTCC CCGGGATGTG GCTCGGGACC GCATGCACCA TGACATCGTT 
CGCCTCCTGG ACGAGTATAA CGTGACTCCC AGCCCTCCGG GAACGGTCTT GACTTCTGCG 
CTCTCACCTG TCCTCTGTGG GCCCAACAGG TCTTTCCTCA GTCTGAAGCA CACCCCAATG 
GGTAAGAAGG CTAGGCGGCC CAACACCAAG AGCACCATGC CCACGAGCCT GCCTAACCTT 
GCCAAGGAGG CCAAGGATGC CAAGGGCAGC AGGAGGAAGA AGTGTCTGAA CGAGAAGGTC 
CAGCTGTCCG AGAGCTCAGT GACTCTATCC CCCGTCGATT CGCTCGAGTC TCCTCACACG 
TATGTCTCCG ATGCCACATC CTCTCCCATG ATCACATCCC CTGGAATCTT ACAGGCCTCG 
CCCACCCCCC TGCTGGCTGC TGCCGCCCCG GCTGCCCCAG TGCACACACA GCATGCGCTG 
TCTTTCTCTA ACCTTCATGA CATGCAGCCT TTGGCTCCTG GAGCCAGCAC CGTGCTCCCC 
TCGGTCAGCC AGCTGCTATC CCACCACCAC ATCGCGCCCC CAGGTAGTAG CAGTGCAGGA 
AGCTTGGGCA GGTTACATCC AGTTCCTGTC CCAGCAGACT GGATGAACCG TGTGGAGATG 
AACGAGACCC AGTACAGTGA AATGTTTGGC ATGGTCCTGG CTCCTGCAGA GGGAGCCCAC 
CCTGGCATAG CAGCTCCCCA GAGCAGACCT CCGGAAGGGA AGCACATGTC CACCCAGCGG 
GAGCCCTTGC CTCCCATCGT GACTTTCCAG CTTATCCCAA AAGGCAGCAT TGCCCAGGCA 
GCCGGAGCTC CCCAGACGCA GTCCAGTTGC CCTCCAGCTG TTGCAGGCCC CTTGCCCTCT 
ATGTACCAGA TCCCAGAGAT GCCCCGTTTG CCCAGTGTGG CTTTCCCACC TACCATGATG 
CCCCAGCAGG AGGGGCAGGT AGCTCAGACC ATTGTGCCAA CCTATCATCC TTTCCCAGCC 
TCTGTGGGCA AGTACCCCAC ACCCCCTTCC CAACACAGTT ACGCCTCCTC AAATGCTGCT 
GAGCGAACCC CCAGTCATGG TGGTCACCTC CAGGGCGAGC ACCCATACCT GACACCATCC 
CCAGAGTCTC CTGACCAATG GTCAAGCTCT TCACCACACT CTGCATCTGA CTGGTCAGAT 
GTGACCACCA GCCCAACTCC TGGAGGTGGT GGAGGCGGTC AGCGGGGACC CGGAACACAC 
ATGTCCGAGC CACCACACAG CAACATGCAG GTGTATGCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035058.2
CDS	162..7583
Translation	MPALRPAALRALLWLWLCGAGPAHALQCRGGQEPCVNEGTCVTYHNGTGFCRCPEGFLGEYCQHRDPCEKNRCQNGGTCVPQGMLGKATCRCAPGFTGEDCQYSTSHPCFVSRPCQNGGTCHMLSRDTYECTCQVGFTGKQCQWTDACLSHPCENGSTCTSVASQFSCKCPAGLTGQKCEADINECDIPGRCQHGGTCLNLPGSYRCQCPQGFTGQHCDSPYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHKCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCTNRNGGYGCVCVNGWSGDDCSENIDDCAYASCTPGSTCIDRVASFSCLCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEVNECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGILCDENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGLNCEINFDDCASNPCMHGVCVDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINDVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGVNCEVDKNECLSNPCQNGGTCNNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDVSGYTCHCMLPYTGKNCQTVLAPCSPNPCENAAVCKEAPNFESFSCLCAPGWQGKRCTVDVDECISKPCMNNGVCHNTQGSYVCECPPGFSGMDCEEDINDCLANPCQNGGSCVDHVNTFSCQCHPGFIGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCTCPAGFHGVHCENNIDECTESSCFNGGTCVDGINSFSCLCPVGFTGPFCLHDINECSSNPCLNAGTCVDGLGTYRCICPLGYTGKNCQTLVNLCSRSPCKNKGTCVQEKARPHCLCPPGWDGAYCDVLNVSCKAAALQKGVPVEHLCQHSGICINAGNTHHCQCPLGYTGSYCEEQLDECASNPCQHGATCNDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDECAGGPHCLNGGQCVDRIGGYTCRCLPGFAGERCEGDINECLSNPCSSEGSLDCVQLKNNYNCICRSAFTGRHCETFLDVCPQKPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRRGEQCIHTDSGPRCFCLNPKDCESGCASNPCQHGGTCYPQRQPPHYSCRCPPSFGGSHCELYTAPTSTPPATCQSQYCADKARDGICDEACNSHACQWDGGDCSLTMEDPWANCTSTLRCWEYINNQCDEQCNTAECLFDNFECQRNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCASDQPENLAEGTLIIVVLLPPEQLLQDSRSFLRALGTLLHTNLRIKQDSQGALMVYPYFGEKSAAMKKQKMTRRSLPEEQEQEQEVIGSKIFLEIDNRQCVQDSDQCFKNTDAAAALLASHAIQGTLSYPLVSVFSELESPRNAQLLYLLAVAVVIILFFILLGVIMAKRKRKHGFLWLPEGFTLRRDSSNHKRREPVGQDAVGLKNLSVQVSEANLIGSGTSEHWVDDEGPQPKKAKAEDEALLSEDDPIDRRPWTQQHLEAADIRHTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVLCGPNRSFLSLKHTPMGKKARRPNTKSTMPTSLPNLAKEAKDAKGSRRKKCLNEKVQLSESSVTLSPVDSLESPHTYVSDATSSPMITSPGILQASPTPLLAAAAPAAPVHTQHALSFSNLHDMQPLAPGASTVLPSVSQLLSHHHIAPPGSSSAGSLGRLHPVPVPADWMNRVEMNETQYSEMFGMVLAPAEGAHPGIAAPQSRPPEGKHMSTQREPLPPIVTFQLIPKGSIAQAAGAPQTQSSCPPAVAGPLPSMYQIPEMPRLPSVAFPPTMMPQQEGQVAQTIVPTYHPFPASVGKYPTPPSQHSYASSNAAERTPSHGGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGGGGGQRGPGTHMSEPPHSNMQVYA

Target ORF information:

RefSeq Version	NM_010928.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus notch 2 (Notch2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010928.2

ORF Insert Sequence:

ATGCCCGCTC TGCGTCCCGC CGCGCTGCGG GCGCTGCTGT GGCTCTGGCT GTGCGGCGCG 
GGCCCCGCGC ACGCTTTGCA GTGTCGAGGT GGTCAAGAGC CCTGTGTAAA TGAAGGGACC 
TGTGTTACCT ACCACAACGG CACAGGCTTC TGCCGATGTC CAGAGGGCTT CTTGGGAGAA 
TATTGCCAAC ATCGAGACCC CTGTGAGAAA AACCGCTGTC AGAATGGTGG TACTTGTGTG 
CCGCAGGGCA TGTTGGGGAA AGCTACCTGC CGATGTGCTC CAGGATTCAC AGGAGAGGAC 
TGCCAATACT CCACCTCTCA CCCCTGCTTT GTGTCCCGCC CTTGTCAGAA TGGGGGTACC 
TGTCACATGC TCAGCCGGGA CACCTACGAG TGCACCTGCC AAGTCGGCTT CACAGGGAAG 
CAGTGTCAGT GGACAGATGC CTGTCTATCT CATCCCTGCG AAAATGGAAG CACCTGTACA 
TCTGTGGCCA GCCAGTTCTC CTGCAAATGC CCTGCAGGCC TCACAGGGCA GAAGTGTGAA 
GCTGATATCA ATGAGTGTGA CATTCCAGGA CGCTGCCAAC ATGGTGGCAC CTGCCTCAAC 
CTTCCTGGTT CCTACAGATG CCAATGTCCT CAGGGCTTCA CAGGCCAGCA CTGTGACAGC 
CCTTATGTGC CCTGTGCACC CTCGCCCTGC GTCAACGGAG GCACCTGTCG TCAGACTGGC 
GACTTCACTT TCGAATGCAA CTGCCTGCCA GGTTTTGAAG GGAGCACCTG TGAGCGGAAT 
ATCGACGACT GCCCCAACCA CAAGTGTCAG AATGGAGGAG TTTGTGTGGA TGGTGTCAAT 
ACCTACAATT GCCGCTGTCC CCCTCAGTGG ACTGGGCAGT TCTGCACAGA AGATGTGGAC 
GAGTGTCTGT TGCAGCCCAA CGCTTGTCAG AATGGAGGCA CCTGCACCAA CCGAAACGGA 
GGCTATGGCT GCGTGTGTGT GAACGGCTGG AGCGGAGATG ACTGCAGCGA GAATATCGAT 
GACTGTGCCT ATGCTTCCTG CACGCCAGGG TCCACCTGCA TTGACCGCGT GGCCTCCTTC 
TCCTGCCTGT GTCCGGAGGG AAAGGCGGGT CTCCTGTGCC ATCTGGATGA TGCCTGTATC 
AGCAACCCTT GTCACAAGGG GGCGCTGTGT GACACCAACC CCCTGAACGG GCAGTACATT 
TGCACCTGCC CACAGGGCTA CAAGGGCGCT GACTGCACAG AAGACGTGGA TGAGTGTGCT 
ATGGCCAACA GTAACCCTTG TGAGCATGCA GGAAAGTGTG TGAATACAGA TGGCGCCTTC 
CACTGTGAGT GTCTGAAGGG CTACGCAGGG CCTCGCTGTG AGATGGACAT CAACGAGTGT 
CATTCAGACC CCTGCCAGAA CGACGCCACC TGCCTGGATA AGATCGGAGG CTTCACCTGT 
CTGTGCATGC CAGGTTTCAA AGGTGTGCAT TGTGAGCTGG AGGTAAATGA ATGCCAGAGC 
AACCCGTGTG TGAACAACGG GCAGTGTGTG GACAAAGTCA ACCGCTTCCA GTGTCTGTGT 
CCCCCTGGCT TCACAGGACC AGTGTGCCAG ATCGACATTG ATGACTGCTC CAGTACTCCC 
TGCCTGAATG GGGCCAAGTG CATCGATCAC CCGAATGGCT ATGAATGCCA GTGTGCCACA 
GGTTTCACTG GCATATTGTG TGATGAGAAC ATCGACAACT GTGACCCAGA TCCTTGCCAC 
CATGGCCAGT GCCAGGATGG GATCGACTCC TACACCTGCA TCTGCAACCC TGGGTACATG 
GGAGCCATCT GTAGTGACCA GATTGATGAA TGCTACAGCA GCCCTTGCTT GAACGATGGG 
CGCTGCATTG ACCTGGTGAA TGGTTACCAG TGCAACTGCC AACCAGGCAC ATCAGGCCTT 
AATTGTGAAA TTAATTTTGA TGACTGTGCC AGCAACCCTT GTATGCACGG AGTCTGTGTG 
GACGGCATCA ATCGCTACAG CTGTGTGTGC TCTCCGGGAT TCACAGGCCA GAGGTGCAAT 
ATTGACATTG ATGAGTGTGC CTCCAACCCC TGTCGCAAGG GTGCGACGTG CATCAATGAT 
GTGAATGGTT TCCGGTGTAT ATGCCCCGAG GGACCGCATC ATCCTAGCTG CTACTCACAG 
GTGAACGAGT GCCTGAGCAA TCCCTGCATC CACGGAAACT GTACTGGAGG TCTCAGTGGC 
TATAAGTGCC TCTGCGATGC AGGCTGGGTT GGTGTCAACT GTGAGGTGGA CAAAAATGAG 
TGTCTTTCTA ACCCATGCCA GAATGGAGGA ACGTGCAATA ACCTGGTGAA TGGCTACAGG 
TGTACCTGCA AGAAGGGGTT CAAAGGCTAC AACTGCCAGG TGAATATAGA TGAGTGTGCC 
TCCAACCCGT GTCTGAACCA AGGAACCTGC TTTGATGACG TCAGTGGCTA CACTTGCCAC 
TGCATGTTGC CTTACACAGG CAAGAACTGT CAAACAGTGT TGGCTCCCTG TTCCCCAAAC 
CCGTGTGAGA ATGCTGCTGT TTGTAAAGAG GCACCCAATT TTGAGAGCTT CAGCTGCTTG 
TGTGCTCCTG GCTGGCAAGG TAAACGATGT ACAGTTGACG TTGATGAGTG TATCTCCAAG 
CCGTGTATGA ACAATGGTGT CTGCCACAAC ACTCAGGGCA GCTACGTGTG TGAGTGTCCT 
CCCGGCTTCA GTGGGATGGA CTGTGAAGAG GACATCAATG ATTGCCTTGC CAACCCCTGC 
CAGAACGGAG GCTCCTGTGT GGACCATGTG AATACCTTCT CCTGCCAGTG CCATCCTGGC 
TTCATAGGGG ACAAGTGCCA GACAGACATG AATGAGTGTC TGAGCGAGCC CTGTAAGAAT 
GGGGGGACCT GCTCCGACTA TGTCAACAGT TACACCTGCA CATGCCCTGC GGGCTTCCAC 
GGAGTCCACT GTGAAAACAA CATTGACGAG TGCACTGAGA GCTCCTGCTT CAATGGCGGC 
ACGTGTGTTG ATGGAATCAA CTCTTTCTCT TGCTTGTGCC CCGTGGGTTT CACTGGTCCC 
TTCTGCCTCC ATGATATCAA TGAGTGCAGC TCTAACCCGT GCCTGAATGC TGGAACGTGT 
GTTGATGGTC TGGGTACCTA CCGATGCATC TGTCCCTTGG GCTACACCGG GAAAAACTGT 
CAGACCCTGG TGAACCTCTG CAGCCGGTCT CCGTGTAAAA ACAAAGGAAC TTGTGTTCAG 
GAAAAGGCAA GGCCCCACTG TCTGTGTCCG CCTGGATGGG ATGGTGCATA CTGTGATGTG 
CTCAACGTGT CCTGTAAGGC GGCAGCCTTG CAGAAAGGAG TACCTGTTGA ACACTTGTGC 
CAGCACTCGG GCATCTGTAT CAATGCTGGC AACACCCATC ACTGCCAGTG CCCCCTGGGC 
TACACGGGGA GCTACTGCGA GGAGCAGCTT GATGAGTGTG CATCCAATCC ATGCCAGCAC 
GGTGCCACCT GCAATGACTT CATCGGAGGA TACAGATGTG AGTGTGTTCC AGGATATCAG 
GGTGTCAACT GTGAGTATGA AGTGGACGAG TGCCAGAACC AACCCTGCCA GAATGGAGGC 
ACCTGCATCG ACCTTGTGAA CCATTTCAAG TGTTCGTGTC CCCCAGGCAC CCGGGGCCTG 
CTGTGTGAAG AGAACATCGA TGAATGTGCT GGGGGCCCCC ACTGCCTTAA CGGTGGCCAG 
TGCGTGGACC GGATTGGAGG CTACACTTGT CGCTGTTTGC CTGGCTTTGC TGGGGAGCGG 
TGTGAGGGGG ACATCAACGA ATGCCTGTCC AACCCTTGCA GCTCAGAGGG CAGCCTGGAC 
TGCGTTCAGC TCAAAAATAA CTACAACTGT ATCTGCCGCA GCGCCTTCAC GGGCCGGCAC 
TGTGAAACCT TCCTAGATGT GTGTCCCCAG AAGCCTTGCC TGAACGGAGG GACTTGTGCC 
GTGGCTAGCA ACATGCCCGA TGGCTTCATC TGTCGTTGTC CCCCAGGGTT CTCTGGGGCG 
AGATGCCAGA GCAGCTGTGG ACAAGTGAAG TGCAGGAGAG GGGAGCAGTG TATCCACACT 
GACTCGGGAC CTCGCTGCTT CTGCCTGAAC CCCAAGGACT GCGAGTCAGG ATGTGCCAGT 
AACCCCTGCC AGCATGGGGG CACCTGCTAT CCTCAGCGCC AGCCTCCTCA CTATTCCTGC 
CGCTGCCCTC CGTCGTTCGG GGGCAGCCAC TGCGAACTCT ACACAGCCCC CACCAGCACC 
CCTCCTGCTA CCTGTCAGAG TCAGTACTGC GCCGACAAGG CTCGGGATGG CATCTGTGAC 
GAGGCCTGCA ATAGTCATGC CTGCCAGTGG GATGGAGGTG ACTGTTCCCT CACTATGGAG 
GACCCCTGGG CCAACTGCAC CTCCACTCTT CGCTGCTGGG AATACATCAA CAACCAGTGT 
GATGAGCAGT GCAACACCGC AGAGTGCCTG TTTGACAACT TTGAGTGCCA GAGGAATAGC 
AAGACGTGCA AGTATGACAA ATACTGTGCA GACCACTTCA AAGACAACCA CTGTGATCAG 
GGATGCAACA GCGAGGAGTG TGGCTGGGAT GGGCTGGACT GCGCTTCGGA CCAGCCTGAG 
AACCTGGCAG AGGGCACCCT GATCATCGTG GTGCTCCTGC CCCCTGAACA GCTGCTGCAG 
GATTCGCGAA GCTTCTTGAG GGCCCTGGGC ACCCTGCTCC ACACCAACTT GCGCATTAAA 
CAAGATTCTC AGGGCGCTCT CATGGTGTAC CCCTACTTTG GGGAGAAGTC AGCTGCCATG 
AAGAAGCAGA AGATGACACG CAGGTCTCTT CCTGAGGAGC AGGAGCAGGA GCAGGAGGTG 
ATAGGCTCTA AGATATTTCT GGAGATCGAC AACCGACAGT GTGTTCAAGA TTCAGACCAG 
TGCTTCAAAA ACACAGATGC GGCAGCTGCT CTCCTGGCTT CTCATGCCAT CCAAGGGACC 
CTATCCTACC CTCTAGTGTC TGTTTTCAGT GAACTGGAGA GTCCAAGAAA CGCCCAGCTT 
CTCTATCTGC TCGCGGTCGC TGTTGTCATC ATCCTGTTCT TCATCCTGCT GGGGGTCATC 
ATGGCCAAGC GGAAGCGCAA GCATGGCTTC CTCTGGCTGC CGGAAGGGTT CACCCTCCGC 
CGAGACTCTA GCAATCACAA GCGCCGTGAA CCTGTGGGAC AGGATGCCGT GGGGCTGAAA 
AATCTCTCCG TGCAAGTGTC AGAGGCTAAC CTGATTGGTT CTGGGACAAG TGAACATTGG 
GTTGATGATG AAGGACCCCA GCCAAAGAAA GCCAAGGCTG AGGATGAGGC TTTGCTGTCG 
GAAGATGACC CCATCGATCG ACGGCCCTGG ACACAGCAGC ACCTTGAAGC TGCAGACATC 
CGCCACACTC CATCCCTGGC ACTCACTCCT CCTCAGGCAG AACAGGAGGT GGACGTGCTG 
GACGTGAATG TCCGAGGCCC AGATGGGTGT ACTCCACTGA TGCTGGCTTC TCTCCGAGGA 
GGCAGCTCAG ACCTGAGTGA TGAAGACGAA GATGCTGAGG ACTCTTCTGC CAACATCATC 
ACAGACTTGG TCTACCAAGG TGCCAGCCTT CAAGCACAGA CAGACCGCAC TGGCGAGATG 
GCCCTGCACC TTGCAGCCCG CTATTCGAGA GCTGATGCTG CCAAACGCCT CCTGGATGCT 
GGTGCGGATG CAAATGCCCA GGACAACATG GGCCGATGTC CTCTTCACGC TGCGGTGGCA 
GCAGACGCCC AAGGTGTCTT TCAGATTCTG ATCCGCAACC GTGTAACCGA TCTGGATGCC 
AGAATGAACG ATGGTACTAC CCCCCTGATC CTGGCTGCCC GCCTGGCTGT GGAAGGAATG 
GTGGCAGAGT TGATCAATTG CCAAGCAGAT GTCAATGCAG TGGATGACCA TGGAAAATCT 
GCCCTCCACT GGGCAGCTGC TGTCAATAAT GTGGAGGCGA CTCTTCTGCT GTTGAAGAAT 
GGGGCCAACA GAGATATGCA GGACAATAAG GAAGAGACAC CTTTGTTTCT TGCTGCCCGA 
GAGGGAAGTT ATGAAGCGGC CAAAATCCTG TTAGACCATT TTGCCAACCG GGACATCACT 
GACCACATGG ACCGCCTTCC CCGGGATGTG GCTCGGGACC GCATGCACCA TGACATCGTT 
CGCCTCCTGG ACGAGTATAA CGTGACTCCC AGCCCTCCGG GAACGGTCTT GACTTCTGCG 
CTCTCACCTG TCCTCTGTGG GCCCAACAGG TCTTTCCTCA GTCTGAAGCA CACCCCAATG 
GGTAAGAAGG CTAGGCGGCC CAACACCAAG AGCACCATGC CCACGAGCCT GCCTAACCTT 
GCCAAGGAGG CCAAGGATGC CAAGGGCAGC AGGAGGAAGA AGTGTCTGAA CGAGAAGGTC 
CAGCTGTCCG AGAGCTCAGT GACTCTATCC CCCGTCGATT CGCTCGAGTC TCCTCACACG 
TATGTCTCCG ATGCCACATC CTCTCCCATG ATCACATCCC CTGGAATCTT ACAGGCCTCG 
CCCACCCCCC TGCTGGCTGC TGCCGCCCCG GCTGCCCCAG TGCACACACA GCATGCGCTG 
TCTTTCTCTA ACCTTCATGA CATGCAGCCT TTGGCTCCTG GAGCCAGCAC CGTGCTCCCC 
TCGGTCAGCC AGCTGCTATC CCACCACCAC ATCGCGCCCC CAGGTAGTAG CAGTGCAGGA 
AGCTTGGGCA GGTTACATCC AGTTCCTGTC CCAGCAGACT GGATGAACCG TGTGGAGATG 
AACGAGACCC AGTACAGTGA AATGTTTGGC ATGGTCCTGG CTCCTGCAGA GGGAGCCCAC 
CCTGGCATAG CAGCTCCCCA GAGCAGACCT CCGGAAGGGA AGCACATGTC CACCCAGCGG 
GAGCCCTTGC CTCCCATCGT GACTTTCCAG CTTATCCCAA AAGGCAGCAT TGCCCAGGCA 
GCCGGAGCTC CCCAGACGCA GTCCAGTTGC CCTCCAGCTG TTGCAGGCCC CTTGCCCTCT 
ATGTACCAGA TCCCAGAGAT GCCCCGTTTG CCCAGTGTGG CTTTCCCACC TACCATGATG 
CCCCAGCAGG AGGGGCAGGT AGCTCAGACC ATTGTGCCAA CCTATCATCC TTTCCCAGCC 
TCTGTGGGCA AGTACCCCAC ACCCCCTTCC CAACACAGTT ACGCCTCCTC AAATGCTGCT 
GAGCGAACCC CCAGTCATGG TGGTCACCTC CAGGGCGAGC ACCCATACCT GACACCATCC 
CCAGAGTCTC CTGACCAATG GTCAAGCTCT TCACCACACT CTGCATCTGA CTGGTCAGAT 
GTGACCACCA GCCCAACTCC TGGAGGTGGT GGAGGCGGTC AGCGGGGACC CGGAACACAC 
ATGTCCGAGC CACCACACAG CAACATGCAG GTGTATGCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.
Science (New York, N.Y.)364(6440)(2019 05)
Telley L,Agirman G,Prados J,Amberg N,Fièvre S,Oberst P,Bartolini G,Vitali I,Cadilhac C,Hippenmeyer S,Nguyen L,Dayer A,Jabaudon D

Constitutive activation of Notch2 signalling confers chemoresistance to neural stem cells via transactivation of fibroblast growth factor receptor-1.
Stem cell research35101390(2019 03)
Tomé M,Tchorz J,Gassmann M,Bettler B

Mature IgD
Nature communications10(1)190(2019 01)
Ray A,Khalil MI,Pulakanti KL,Burns RT,Gurski CJ,Basu S,Wang D,Rao S,Dittel BN

miR-181b/Notch2 overcome chemoresistance by regulating cancer stem cell-like properties in NSCLC.
Stem cell research & therapy9(1)327(2018 11)
Wang X,Meng Q,Qiao W,Ma R,Ju W,Hu J,Lu H,Cui J,Jin Z,Zhao Y,Wang Y

A perivascular niche for multipotent progenitors in the fetal testis.
Nature communications9(1)4519(2018 10)
Kumar DL,DeFalco T

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Notch2 cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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