Klk1c3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klk1c3
Entrez Gene ID	292872
Full Name	kallikrein 1-related peptidase C3
Synonyms	KLK3,Klk1c10l2,RSGK-50,RSKG-50,rGK-3
General protein information	Preferred Names kallikrein 1-related peptidase C3 Names glandular kallikrein-3, submandibular S1 kallikrein kallikrein 1-related peptidase c10-like 2 kallikrein 3 submaxillary gland S1 kallikrein tissue kallikrein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q22
Summary	a putative kallikrein-related serine protease first isolated from the rat submaxillary gland [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017588921.1	XP_017444410.1	glandular kallikrein-3, submandibular isoform X1
NM_001271315.1	NP_001258244.1	glandular kallikrein-3, submandibular precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Klk1c2	NP_036809.1
Rattus norvegicus (Norway rat)	Klk1c9	NP_786935.1
Rattus norvegicus (Norway rat)	LOC100911689	XP_003748896.1
Homo sapiens (human)	KLK1	NP_002248.1
Canis lupus familiaris (dog)	KLK1	NP_001003262.1
Rattus norvegicus (Norway rat)	Klk1c7	NP_036725.1
Rattus norvegicus (Norway rat)	Klk1c10	NP_001128645.1
Rattus norvegicus (Norway rat)	LOC100911764	XP_003748897.1
Bos taurus (cattle)	KLK1	NP_001008416.1
Rattus norvegicus (Norway rat)	Klk1	NP_113711.1
Rattus norvegicus (Norway rat)	Klk1c12	NP_001005382.1
Rattus norvegicus (Norway rat)	Klk1c6	NP_001003977.1
Rattus norvegicus (Norway rat)	LOC687880	XP_006229230.1
Rattus norvegicus (Norway rat)	Klk1c8	NP_001013085.1
Rattus norvegicus (Norway rat)	Klk1c3	NP_001258244.1

Gene Ontology
Bibliography

Related articles in PubMed

Tissue kallikrein promotes neovascularization and improves cardiac function by the Akt-glycogen synthase kinase-3beta pathway.
Yao YY, Yin H, Shen B, Smith RS Jr, Liu Y, Gao L, Chao L, Chao J
Cardiovascular research80(3)354-64(2008 Dec)

Nitric oxide mediates cardiac protection of tissue kallikrein by reducing inflammation and ventricular remodeling after myocardial ischemia/reperfusion.
Yin H, Chao L, Chao J
Life sciences82(3-4)156-65(2008 Jan)

Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat.
Iwai N, Yasui N, Naraba H, Tago N, Yamawaki H, Sumiya H
Hypertension (Dallas, Tex. : 1979)45(5)947-53(2005 May)

Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen.
Olsson AY, Lilja H, Lundwall A
Genomics84(1)147-56(2004 Jul)

The transcriptional regulatory strategy of the rat tissue kallikrein gene family.
Kroon E, MacDonald RJ, Hammer RE
Genes and function1(5-6)309-19(1997 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Klk1c3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klk1c3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10965	NM_001271315.1 Latest version!	Rattus norvegicus kallikrein 1-related peptidase C3 (Klk1c3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa56448	XM_017588921.1 Latest version!	Rattus norvegicus kallikrein 1-related peptidase C3 (Klk1c3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klk1c3 ( NM_001271315.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001258244.1 Rattus norvegicus kallikrein 1-related peptidase C3 (Klk1c3), mRNA.

Price & Availability↑

CloneID	ORa10965
Clone ID Related Accession (Same CDS sequence)	NM_001271315.1
Accession Version	NM_001271315.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Rattus norvegicus(Norway rat)
Product	glandular kallikrein-3, submandibular precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07003250.1. On or before Dec 15, 2013 this sequence version replaced XM_006229169.1, XM_006223254.1, XM_002725575.2, XM_002728758.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2689601 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGGTTCC TGATCCTGTT CCTTGCCCTG TCCCTGGGAC AGATTGATGC TGCACCTCCT 
GGCCAGTCTC GAGTTGTTGG AGGATTTAAA TGTGAGAAGA ATTCCCAACC CTGGCAAGTG 
GCTGTCATCA ATGAAGACCT ATGCGGGGGT GTCCTGATAG ACCCCAGCTG GGTGATCACA 
GCTGCCCACT GCTATAGTGA CAATTACCAT GTTTTGCTGG GTCAAAATAA CCTATCTGAA 
GATGTTCAGC ACCGGCTTGT CAGCCAAAGC TTCCGACACC CTGACTACAA ACCATTCCTC 
ATGAGGAACC ACACCCGAAA ACCTAAGGAC TACAGCAATG ACCTGATGCT GCTCCACCTC 
AGCGAGCCTG CGGACATCAC AGATGGGGTG AAGGTCATCG ATCTGCCCAC GAAGGAGCCC 
AAGGTGGGGA GCACCTGCCT TGTCTCAGGC TGGGGCAGCA CCAACCCCTC TGAGTGGGAA 
TTCCCTGATG ATCTCCAGTG TGTGAACATC CACCTACTGT CTAATGAGAA GTGCATCAAA 
GCCTACAAAG AAAAGGTGAC AGATCTGATG CTGTGTGCAG GAGAGTTGGA AGGAGGCAAA 
GACACTTGCA GGGGTGACTC AGGAGGCCCC CTCATCTGTG ATGGTGTGCT CCAGGGCATC 
ACATCATGGG GCTCTGTCCC ATGCGGTGAA CCCAATAAGC CAGGCATCTA CACCAAACTT 
ATTAAGTTCA CCTCCTGGAT AAAAGAAGTT ATGAAGAAAA ACCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258244.1
CDS	1..768
Translation	MWFLILFLALSLGQIDAAPPGQSRVVGGFKCEKNSQPWQVAVINEDLCGGVLIDPSWVITAAHCYSDNYHVLLGQNNLSEDVQHRLVSQSFRHPDYKPFLMRNHTRKPKDYSNDLMLLHLSEPADITDGVKVIDLPTKEPKVGSTCLVSGWGSTNPSEWEFPDDLQCVNIHLLSNEKCIKAYKEKVTDLMLCAGELEGGKDTCRGDSGGPLICDGVLQGITSWGSVPCGEPNKPGIYTKLIKFTSWIKEVMKKNP

Target ORF information:

RefSeq Version	NM_001271315.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus kallikrein 1-related peptidase C3 (Klk1c3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271315.1

ORF Insert Sequence:

ATGTGGTTCC TGATCCTGTT CCTTGCCCTG TCCCTGGGAC AGATTGATGC TGCACCTCCT 
GGCCAGTCTC GAGTTGTTGG AGGATTTAAA TGTGAGAAGA ATTCCCAACC CTGGCAAGTG 
GCTGTCATCA ATGAAGACCT ATGCGGGGGT GTCCTGATAG ACCCCAGCTG GGTGATCACA 
GCTGCCCACT GCTATAGTGA CAATTACCAT GTTTTGCTGG GTCAAAATAA CCTATCTGAA 
GATGTTCAGC ACCGGCTTGT CAGCCAAAGC TTCCGACACC CTGACTACAA ACCATTCCTC 
ATGAGGAACC ACACCCGAAA ACCTAAGGAC TACAGCAATG ACCTGATGCT GCTCCACCTC 
AGCGAGCCTG CGGACATCAC AGATGGGGTG AAGGTCATCG ATCTGCCCAC GAAGGAGCCC 
AAGGTGGGGA GCACCTGCCT TGTCTCAGGC TGGGGCAGCA CCAACCCCTC TGAGTGGGAA 
TTCCCTGATG ATCTCCAGTG TGTGAACATC CACCTACTGT CTAATGAGAA GTGCATCAAA 
GCCTACAAAG AAAAGGTGAC AGATCTGATG CTGTGTGCAG GAGAGTTGGA AGGAGGCAAA 
GACACTTGCA GGGGTGACTC AGGAGGCCCC CTCATCTGTG ATGGTGTGCT CCAGGGCATC 
ACATCATGGG GCTCTGTCCC ATGCGGTGAA CCCAATAAGC CAGGCATCTA CACCAAACTT 
ATTAAGTTCA CCTCCTGGAT AAAAGAAGTT ATGAAGAAAA ACCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klk1c3 ( XM_017588921.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444410.1 Rattus norvegicus kallikrein 1-related peptidase C3 (Klk1c3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa56448
Clone ID Related Accession (Same CDS sequence)	XM_017588921.1
Accession Version	XM_017588921.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	glandular kallikrein-3, submandibular isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGGGGGT GTCCTGATAG ACCCCAGCTG GGTGATCACA GCTGCCCACT GCTATACAAT 
TACCATGTTT TGCTGGGTCA AAATAACCTA TCTGAAGATG TTCAGCACCG GCTTGTCAGC 
CAAAGCTTCC GACACCCTGA CTACAAACCA TTCCTCATGA GGAACCACAC CCGAAAACCT 
AAGGACTACA GCAATGACCT GATGCTGCTC CACCTCAGCG AGCCTGCGGA CATCACAGAT 
GGGGTGAAGG TCATCGATCT GCCCACGAAG GAGCCCAAGG TGGGGAGCAC CTGCCTTGTC 
TCAGGCTGGG GCAGCACCAA CCCCTCTGAG TGGGAATTCC CTGATGATCT CCAGTGTGTG 
AACATCCACC TACTGTCTAA TGAGAAGTGC ATCAAAGCCT ACAAAGAAAA GGTGACAGAT 
CTGATGCTGT GTGCAGGAGA GTTGGAAGGA GGCAAAGACA CTTGCAGGGG TGACTCAGGA 
GGCCCCCTCA TCTGTGATGG TGTGCTCCAG GGCATCACAT CATGGGGCTC TGTCCCATGC 
GGTGAACCCA ATAAGCCAGG CATCTACACC AAACTTATTA AGTTCACCTC CTGGATAAAA 
GAAGTTATGA AGAAAAACCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444410.1
CDS	303..926
Translation	MRGCPDRPQLGDHSCPLLYNYHVLLGQNNLSEDVQHRLVSQSFRHPDYKPFLMRNHTRKPKDYSNDLMLLHLSEPADITDGVKVIDLPTKEPKVGSTCLVSGWGSTNPSEWEFPDDLQCVNIHLLSNEKCIKAYKEKVTDLMLCAGELEGGKDTCRGDSGGPLICDGVLQGITSWGSVPCGEPNKPGIYTKLIKFTSWIKEVMKKNP

Target ORF information:

RefSeq Version	XM_017588921.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus kallikrein 1-related peptidase C3 (Klk1c3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017588921.1

ORF Insert Sequence:

ATGCGGGGGT GTCCTGATAG ACCCCAGCTG GGTGATCACA GCTGCCCACT GCTATACAAT 
TACCATGTTT TGCTGGGTCA AAATAACCTA TCTGAAGATG TTCAGCACCG GCTTGTCAGC 
CAAAGCTTCC GACACCCTGA CTACAAACCA TTCCTCATGA GGAACCACAC CCGAAAACCT 
AAGGACTACA GCAATGACCT GATGCTGCTC CACCTCAGCG AGCCTGCGGA CATCACAGAT 
GGGGTGAAGG TCATCGATCT GCCCACGAAG GAGCCCAAGG TGGGGAGCAC CTGCCTTGTC 
TCAGGCTGGG GCAGCACCAA CCCCTCTGAG TGGGAATTCC CTGATGATCT CCAGTGTGTG 
AACATCCACC TACTGTCTAA TGAGAAGTGC ATCAAAGCCT ACAAAGAAAA GGTGACAGAT 
CTGATGCTGT GTGCAGGAGA GTTGGAAGGA GGCAAAGACA CTTGCAGGGG TGACTCAGGA 
GGCCCCCTCA TCTGTGATGG TGTGCTCCAG GGCATCACAT CATGGGGCTC TGTCCCATGC 
GGTGAACCCA ATAAGCCAGG CATCTACACC AAACTTATTA AGTTCACCTC CTGGATAAAA 
GAAGTTATGA AGAAAAACCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tissue kallikrein promotes neovascularization and improves cardiac function by the Akt-glycogen synthase kinase-3beta pathway.
Cardiovascular research80(3)354-64(2008 Dec)
Yao YY,Yin H,Shen B,Smith RS Jr,Liu Y,Gao L,Chao L,Chao J

Nitric oxide mediates cardiac protection of tissue kallikrein by reducing inflammation and ventricular remodeling after myocardial ischemia/reperfusion.
Life sciences82(3-4)156-65(2008 Jan)
Yin H,Chao L,Chao J

Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat.
Hypertension (Dallas, Tex. : 1979)45(5)947-53(2005 May)
Iwai N,Yasui N,Naraba H,Tago N,Yamawaki H,Sumiya H

Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen.
Genomics84(1)147-56(2004 Jul)
Olsson AY,Lilja H,Lundwall A

The transcriptional regulatory strategy of the rat tissue kallikrein gene family.
Genes and function1(5-6)309-19(1997 Dec)
Kroon E,MacDonald RJ,Hammer RE