Kars cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kars
Entrez Gene ID	292028
Full Name	lysyl-tRNA synthetase
Synonyms	LysRS
General protein information	Preferred Names lysyl-tRNA synthetase Names lysine--tRNA ligase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19q12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001006967.1	NP_001006968.1	lysine--tRNA ligase
XM_006255630.1	XP_006255692.1	lysine--tRNA ligase isoform X1

Pathways from BioSystems

Homologies

Schizosaccharomyces pombe (fission yeast)	krs1	NP_595892.1
Macaca mulatta (Rhesus monkey)	KARS	XP_001104312.2
Neurospora crassa	NCU04020	XP_957635.1
Canis lupus familiaris (dog)	KARS	XP_861533.1
Saccharomyces cerevisiae (baker's yeast)	KRS1	NP_010322.1
Xenopus tropicalis (tropical clawed frog)	kars	NP_001001255.1
Oryza sativa (rice)	Os03g0586800	NP_001050572.1
Homo sapiens (human)	KARS	NP_001123561.1
Mus musculus (house mouse)	Kars	NP_001124340.1
Danio rerio (zebrafish)	kars	NP_001002386.1
Caenorhabditis elegans (roundworm)	kars-1	NP_495453.1
Kluyveromyces lactis	KLLA0F18392g	XP_455904.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007858	XP_317634.3
Eremothecium gossypii	AGOS_AGR037C	NP_986702.1
Bos taurus (cattle)	KARS	NP_001029528.1
Rattus norvegicus (Norway rat)	Kars	NP_001006968.1
Arabidopsis thaliana (thale cress)	ATKRS-1	NP_187777.1
Magnaporthe oryzae (rice blast fungus)	MGG_04966	XP_003712462.1
Pan troglodytes (chimpanzee)	KARS	XP_003315273.1
Gallus gallus (chicken)	KARS	NP_001025754.1
Drosophila melanogaster (fruit fly)	Aats-lys	NP_727353.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000325	XP_310792.5

Gene Ontology
Bibliography

Related articles in PubMed

Expression profile of aminoacyl-tRNA synthetases in dorsal root ganglion neurons after peripheral nerve injury.
Park BS, Jo HW, Jung J
Journal of molecular histology46(1)115-22(2015 Feb)

Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction.
Kim DG, Lee JY, Kwon NH, Fang P, Zhang Q, Wang J, Young NL, Guo M, Cho HY, Mushtaq AU, Jeon YH, Choi JW, Han JM, Kang HW, Joo JE, Hur Y, Kang W, Yang H, Nam DH, Lee MS, Lee JW, Kim ES, Moon A, Kim K, Kim D, Kang EJ, Moon Y, Rhee KH, Han BW, Yang JS, Han G, Yang WS, Lee C, Wang MW, Kim S
Nature chemical biology10(1)29-34(2014 Jan)

Structural switch of lysyl-tRNA synthetase between translation and transcription.
Ofir-Birin Y, Fang P, Bennett SP, Zhang HM, Wang J, Rachmin I, Shapiro R, Song J, Dagan A, Pozo J, Kim S, Marshall AG, Schimmel P, Yang XL, Nechushtan H, Razin E, Guo M
Molecular cell49(1)30-42(2013 Jan)

Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex.
Fang P, Zhang HM, Shapiro R, Marshall AG, Schimmel P, Yang XL, Guo M
Proceedings of the National Academy of Sciences of the United States of America108(20)8239-44(2011 May)

LysRS serves as a key signaling molecule in the immune response by regulating gene expression.
Yannay-Cohen N, Carmi-Levy I, Kay G, Yang CM, Han JM, Kemeny DM, Kim S, Nechushtan H, Razin E
Molecular cell34(5)603-11(2009 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Kars gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kars cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10640	NM_001006967.1 Latest version!	Rattus norvegicus lysyl-tRNA synthetase (Kars), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa38943	XM_006255630.1 Latest version!	Rattus norvegicus lysyl-tRNA synthetase (Kars), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kars ( NM_001006967.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001006968.1 Rattus norvegicus lysyl-tRNA synthetase (Kars), mRNA.

Price & Availability↑

CloneID	ORa10640
Clone ID Related Accession (Same CDS sequence)	NM_001006967.1
Accession Version	NM_001006967.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1881bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1572019200000
Organism	Rattus norvegicus(Norway rat)
Product	lysine--tRNA ligase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083652.1. On Nov 22, 2004 this sequence version replaced XM_214694.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC083652.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTTGATGC AAGCTGCTGT CAGGCTTGTT AGGGGGTCCC TGCGCCAAAC CTCATGGGCA 
GAATGGGGTC AGAGGGAACT TCGACTGGGC CAACTTGCTC CTTTCACAAC GCTCCGCAAG 
GACAAGCCAC TTTCTGATAG AAGAAGTGAG CTGAAGAGGC GTCTGAAAGC TGAGAAGAAG 
CTGGCAGAGA AAGAGGCCAA GCAGAAAGAG CTCAGTGAAA AGCAGCTAAA CCAGACGACT 
GCTGCTGCTG CCACCAACCA TACTGCTGAC AATGGTGTGG GTGCTGAAGA GGAGACCCTG 
GACCCAAACC AATACTACAA GATCCGTAGT CAAGCTGTCC AGCAGCTGAA GGTCAGTGGG 
GAGGACCCGT ACCCACACAA GTTCCATGTG GACATCTCAC TCACTCAGTT CATCCAAGAA 
TACAGTCACC TGCAGCCTGG GGACCACCTG ACTGACATCA CCTTAAAAGT AGCAGGTCGC 
ATCCACGCCA AGAGAGCCTC TGGGGGAAAG CTCATCTTCT ATGACCTTCG AGGAGAGGGG 
GTCAAGTTAC AAGTCATGGC CAACTCCAGG AATTATAAAT CAGAGGAAGA ATTCGTTCAC 
ATCAATAACA AACTGCGCAG GGGAGACATA ATCGGAGTCG AGGGCAATCC CGGAAAAACC 
AAGAAGGGTG AGCTGAGCAT CGTCCCCCGG GAGATGACAC TCCTGTCCCC CTGCTTGCAC 
ATGCTGCCTC ATCTTCACTT CGGCCTCAAG GACAAGGAAA CAAGGTATCG TCAGAGATAC 
TTGGACTTGA TACTGAACGA CTTTGTGAGG CAGAAGTTTA TCATCCGCTC TAAGATCATC 
ACATATATAA GAAGTTTCTT GGACGAGCTG GGATTCCTAG AGATCGAGAC TCCCATGATG 
AACATCATCC CCGGGGGAGC TGTGGCCAAG CCTTTCATCA CCTACCACAA CGAGCTGGAC 
ATGAACCTGT ACATGAGAAT TGCTCCAGAG CTCTACCACA AGATGCTGGT GGTTGGTGGC 
ATTGACCGGG TTTATGAAAT TGGGCGCCAG TTCCGGAACG AAGGGATTGA TTTGACTCAC 
AATCCTGAGT TCACCACCTG TGAGTTCTAC ATGGCCTATG CAGACTATCA TGACCTCATG 
GAAATCACAG AGAAGATGCT GTCAGGGATG GTGAGAAGCA TCACAGGCAG TTACAAGATC 
ACCTATCACC CAGATGGGCC AGAAGGCCAA GCCTATGAGA TTGACTTCAC CCCACCCTTC 
CGAAGAATCA GCATGGTAGA AGAGCTTGAG AAGGTTCTGG GCGTGAAGCT GCCAGAAACC 
AGTCTCTTTG AGACCGAAGA AACTCGCAAA ATTCTCGATG ATATTTGTGT TGCAAGGGCT 
GTTGAATGCC CCCCACCTCG GACCACAGCC AGGCTCCTTG ATAAGCTTGT GGGAGAGTTC 
CTCGAAGTGA CATGCATCAG CCCTACATTC ATCTGTGATC ACCCACAGAT CATGAGTCCT 
CTGGCCAAAT GGCACCGTTG CAAAGAGGGT CTAACTGAGC GCTTCGAGCT GTTTGTCATG 
AAGAAGGAAA TATGCAATGC GTACACTGAG CTGAACGACC CCGTGCGGCA GAGACAACTG 
TTTGAAGAAC AGGCCAAGGC CAAGGCTGCT GGTGACGATG AGGCCATGTT CATAGATGAG 
AACTTCTGTA CTGCCCTGGA GTACGGGCTG CCCCCAACAG CTGGCTGGGG CATGGGTATC 
GACCGAGTCA CCATGTTTCT CACAGACTCC AACAATATCA AGGAAGTACT TCTCTTTCCT 
GCCATGAAGC CTGAAGACAA GAAGGAAACT GCAACAGCCA CCGAGACCCC AGAAAGCACA 
GAGGCCAGCC CCTCTGTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001006968.1
CDS	92..1972
Translation	MLMQAAVRLVRGSLRQTSWAEWGQRELRLGQLAPFTTLRKDKPLSDRRSELKRRLKAEKKLAEKEAKQKELSEKQLNQTTAAAATNHTADNGVGAEEETLDPNQYYKIRSQAVQQLKVSGEDPYPHKFHVDISLTQFIQEYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFVHINNKLRRGDIIGVEGNPGKTKKGELSIVPREMTLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMLSGMVRSITGSYKITYHPDGPEGQAYEIDFTPPFRRISMVEELEKVLGVKLPETSLFETEETRKILDDICVARAVECPPPRTTARLLDKLVGEFLEVTCISPTFICDHPQIMSPLAKWHRCKEGLTERFELFVMKKEICNAYTELNDPVRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVTMFLTDSNNIKEVLLFPAMKPEDKKETATATETPESTEASPSV

Target ORF information:

RefSeq Version	NM_001006967.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lysyl-tRNA synthetase (Kars), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001006967.1

ORF Insert Sequence:

ATGTTGATGC AAGCTGCTGT CAGGCTTGTT AGGGGGTCCC TGCGCCAAAC CTCATGGGCA 
GAATGGGGTC AGAGGGAACT TCGACTGGGC CAACTTGCTC CTTTCACAAC GCTCCGCAAG 
GACAAGCCAC TTTCTGATAG AAGAAGTGAG CTGAAGAGGC GTCTGAAAGC TGAGAAGAAG 
CTGGCAGAGA AAGAGGCCAA GCAGAAAGAG CTCAGTGAAA AGCAGCTAAA CCAGACGACT 
GCTGCTGCTG CCACCAACCA TACTGCTGAC AATGGTGTGG GTGCTGAAGA GGAGACCCTG 
GACCCAAACC AATACTACAA GATCCGTAGT CAAGCTGTCC AGCAGCTGAA GGTCAGTGGG 
GAGGACCCGT ACCCACACAA GTTCCATGTG GACATCTCAC TCACTCAGTT CATCCAAGAA 
TACAGTCACC TGCAGCCTGG GGACCACCTG ACTGACATCA CCTTAAAAGT AGCAGGTCGC 
ATCCACGCCA AGAGAGCCTC TGGGGGAAAG CTCATCTTCT ATGACCTTCG AGGAGAGGGG 
GTCAAGTTAC AAGTCATGGC CAACTCCAGG AATTATAAAT CAGAGGAAGA ATTCGTTCAC 
ATCAATAACA AACTGCGCAG GGGAGACATA ATCGGAGTCG AGGGCAATCC CGGAAAAACC 
AAGAAGGGTG AGCTGAGCAT CGTCCCCCGG GAGATGACAC TCCTGTCCCC CTGCTTGCAC 
ATGCTGCCTC ATCTTCACTT CGGCCTCAAG GACAAGGAAA CAAGGTATCG TCAGAGATAC 
TTGGACTTGA TACTGAACGA CTTTGTGAGG CAGAAGTTTA TCATCCGCTC TAAGATCATC 
ACATATATAA GAAGTTTCTT GGACGAGCTG GGATTCCTAG AGATCGAGAC TCCCATGATG 
AACATCATCC CCGGGGGAGC TGTGGCCAAG CCTTTCATCA CCTACCACAA CGAGCTGGAC 
ATGAACCTGT ACATGAGAAT TGCTCCAGAG CTCTACCACA AGATGCTGGT GGTTGGTGGC 
ATTGACCGGG TTTATGAAAT TGGGCGCCAG TTCCGGAACG AAGGGATTGA TTTGACTCAC 
AATCCTGAGT TCACCACCTG TGAGTTCTAC ATGGCCTATG CAGACTATCA TGACCTCATG 
GAAATCACAG AGAAGATGCT GTCAGGGATG GTGAGAAGCA TCACAGGCAG TTACAAGATC 
ACCTATCACC CAGATGGGCC AGAAGGCCAA GCCTATGAGA TTGACTTCAC CCCACCCTTC 
CGAAGAATCA GCATGGTAGA AGAGCTTGAG AAGGTTCTGG GCGTGAAGCT GCCAGAAACC 
AGTCTCTTTG AGACCGAAGA AACTCGCAAA ATTCTCGATG ATATTTGTGT TGCAAGGGCT 
GTTGAATGCC CCCCACCTCG GACCACAGCC AGGCTCCTTG ATAAGCTTGT GGGAGAGTTC 
CTCGAAGTGA CATGCATCAG CCCTACATTC ATCTGTGATC ACCCACAGAT CATGAGTCCT 
CTGGCCAAAT GGCACCGTTG CAAAGAGGGT CTAACTGAGC GCTTCGAGCT GTTTGTCATG 
AAGAAGGAAA TATGCAATGC GTACACTGAG CTGAACGACC CCGTGCGGCA GAGACAACTG 
TTTGAAGAAC AGGCCAAGGC CAAGGCTGCT GGTGACGATG AGGCCATGTT CATAGATGAG 
AACTTCTGTA CTGCCCTGGA GTACGGGCTG CCCCCAACAG CTGGCTGGGG CATGGGTATC 
GACCGAGTCA CCATGTTTCT CACAGACTCC AACAATATCA AGGAAGTACT TCTCTTTCCT 
GCCATGAAGC CTGAAGACAA GAAGGAAACT GCAACAGCCA CCGAGACCCC AGAAAGCACA 
GAGGCCAGCC CCTCTGTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kars ( XM_006255630.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006255692.1 Rattus norvegicus lysyl-tRNA synthetase (Kars), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa38943
Clone ID Related Accession (Same CDS sequence)	XM_006255630.1
Accession Version	XM_006255630.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1794bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	lysine--tRNA ligase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCACGC TGCGGGAGGG TGAAGTCAAA TTGGATGGCG AGCCGAAACT AAGCAAGAAT 
GAGCTGAAGA GGCGTCTGAA AGCTGAGAAG AAGCTGGCAG AGAAAGAGGC CAAGCAGAAA 
GAGCTCAGTG AAAAGCAGCT AAACCAGACG ACTGCTGCTG CTGCCACCAA CCATACTGCT 
GACAATGGTG TGGGTGCTGA AGAGGAGACC CTGGACCCAA ACCAATACTA CAAGATCCGT 
AGTCAAGCTG TCCAGCAGCT GAAGGTCAGT GGGGAGGACC CGTACCCACA CAAGTTCCAT 
GTGGACATCT CACTCACTCA GTTCATCCAA GAATACAGTC ACCTGCAGCC TGGGGACCAC 
CTGACTGACA TCACCTTAAA AGTAGCAGGT CGCATCCACG CCAAGAGAGC CTCTGGGGGA 
AAGCTCATCT TCTATGACCT TCGAGGAGAG GGGGTCAAGT TACAAGTCAT GGCCAACTCC 
AGGAATTATA AATCAGAGGA AGAATTCGTT CACATCAATA ACAAACTGCG CAGGGGAGAC 
ATAATCGGAG TCGAGGGCAA TCCCGGAAAA ACCAAGAAGG GTGAGCTGAG CATCGTCCCC 
CGGGAGATGA CACTCCTGTC CCCCTGCTTG CACATGCTGC CTCATCTTCA CTTCGGCCTC 
AAGGACAAGG AAACAAGGTA TCGTCAGAGA TACTTGGACT TGATACTGAA CGACTTTGTG 
AGGCAGAAGT TTATCATCCG CTCTAAGATC ATCACATATA TAAGAAGTTT CTTGGACGAG 
CTGGGATTCC TAGAGATCGA GACTCCCATG ATGAACATCA TCCCCGGGGG AGCTGTGGCC 
AAGCCTTTCA TCACCTACCA CAACGAGCTG GACATGAACC TGTACATGAG AATTGCTCCA 
GAGCTCTACC ACAAGATGCT GGTGGTTGGT GGCATTGACC GGGTTTATGA AATTGGGCGC 
CAGTTCCGGA ACGAAGGGAT TGATTTGACT CACAATCCTG AGTTCACCAC CTGTGAGTTC 
TACATGGCCT ATGCAGACTA TCATGACCTC ATGGAAATCA CAGAGAAGAT GCTGTCAGGG 
ATGGTGAGAA GCATCACAGG CAGTTACAAG ATCACCTATC ACCCAGATGG GCCAGAAGGC 
CAAGCCTATG AGATTGACTT CACCCCACCC TTCCGAAGAA TCAGCATGGT AGAAGAGCTT 
GAGAAGGTTC TGGGCGTGAA GCTGCCAGAA ACCAGTCTCT TTGAGACCGA AGAAACTCGC 
AAAATTCTCG ATGATATTTG TGTTGCAAGG GCTGTTGAAT GCCCCCCACC TCGGACCACA 
GCCAGGCTCC TTGATAAGCT TGTGGGAGAG TTCCTCGAAG TGACATGCAT CAGCCCTACA 
TTCATCTGTG ATCACCCACA GATCATGAGT CCTCTGGCCA AATGGCACCG TTGCAAAGAG 
GGTCTAACTG AGCGCTTCGA GCTGTTTGTC ATGAAGAAGG AAATATGCAA TGCGTACACT 
GAGCTGAACG ACCCCGTGCG GCAGAGACAA CTGTTTGAAG AACAGGCCAA GGCCAAGGCT 
GCTGGTGACG ATGAGGCCAT GTTCATAGAT GAGAACTTCT GTACTGCCCT GGAGTACGGG 
CTGCCCCCAA CAGCTGGCTG GGGCATGGGT ATCGACCGAG TCACCATGTT TCTCACAGAC 
TCCAACAATA TCAAGGAAGT ACTTCTCTTT CCTGCCATGA AGCCTGAAGA CAAGAAGGAA 
ACTGCAACAG CCACCGAGAC CCCAGAAAGC ACAGAGGCCA GCCCCTCTGT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006255692.1
CDS	51..1844
Translation	MATLREGEVKLDGEPKLSKNELKRRLKAEKKLAEKEAKQKELSEKQLNQTTAAAATNHTADNGVGAEEETLDPNQYYKIRSQAVQQLKVSGEDPYPHKFHVDISLTQFIQEYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFVHINNKLRRGDIIGVEGNPGKTKKGELSIVPREMTLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMLSGMVRSITGSYKITYHPDGPEGQAYEIDFTPPFRRISMVEELEKVLGVKLPETSLFETEETRKILDDICVARAVECPPPRTTARLLDKLVGEFLEVTCISPTFICDHPQIMSPLAKWHRCKEGLTERFELFVMKKEICNAYTELNDPVRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVTMFLTDSNNIKEVLLFPAMKPEDKKETATATETPESTEASPSV

Target ORF information:

RefSeq Version	XM_006255630.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lysyl-tRNA synthetase (Kars), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006255630.1

ORF Insert Sequence:

ATGGCCACGC TGCGGGAGGG TGAAGTCAAA TTGGATGGCG AGCCGAAACT AAGCAAGAAT 
GAGCTGAAGA GGCGTCTGAA AGCTGAGAAG AAGCTGGCAG AGAAAGAGGC CAAGCAGAAA 
GAGCTCAGTG AAAAGCAGCT AAACCAGACG ACTGCTGCTG CTGCCACCAA CCATACTGCT 
GACAATGGTG TGGGTGCTGA AGAGGAGACC CTGGACCCAA ACCAATACTA CAAGATCCGT 
AGTCAAGCTG TCCAGCAGCT GAAGGTCAGT GGGGAGGACC CGTACCCACA CAAGTTCCAT 
GTGGACATCT CACTCACTCA GTTCATCCAA GAATACAGTC ACCTGCAGCC TGGGGACCAC 
CTGACTGACA TCACCTTAAA AGTAGCAGGT CGCATCCACG CCAAGAGAGC CTCTGGGGGA 
AAGCTCATCT TCTATGACCT TCGAGGAGAG GGGGTCAAGT TACAAGTCAT GGCCAACTCC 
AGGAATTATA AATCAGAGGA AGAATTCGTT CACATCAATA ACAAACTGCG CAGGGGAGAC 
ATAATCGGAG TCGAGGGCAA TCCCGGAAAA ACCAAGAAGG GTGAGCTGAG CATCGTCCCC 
CGGGAGATGA CACTCCTGTC CCCCTGCTTG CACATGCTGC CTCATCTTCA CTTCGGCCTC 
AAGGACAAGG AAACAAGGTA TCGTCAGAGA TACTTGGACT TGATACTGAA CGACTTTGTG 
AGGCAGAAGT TTATCATCCG CTCTAAGATC ATCACATATA TAAGAAGTTT CTTGGACGAG 
CTGGGATTCC TAGAGATCGA GACTCCCATG ATGAACATCA TCCCCGGGGG AGCTGTGGCC 
AAGCCTTTCA TCACCTACCA CAACGAGCTG GACATGAACC TGTACATGAG AATTGCTCCA 
GAGCTCTACC ACAAGATGCT GGTGGTTGGT GGCATTGACC GGGTTTATGA AATTGGGCGC 
CAGTTCCGGA ACGAAGGGAT TGATTTGACT CACAATCCTG AGTTCACCAC CTGTGAGTTC 
TACATGGCCT ATGCAGACTA TCATGACCTC ATGGAAATCA CAGAGAAGAT GCTGTCAGGG 
ATGGTGAGAA GCATCACAGG CAGTTACAAG ATCACCTATC ACCCAGATGG GCCAGAAGGC 
CAAGCCTATG AGATTGACTT CACCCCACCC TTCCGAAGAA TCAGCATGGT AGAAGAGCTT 
GAGAAGGTTC TGGGCGTGAA GCTGCCAGAA ACCAGTCTCT TTGAGACCGA AGAAACTCGC 
AAAATTCTCG ATGATATTTG TGTTGCAAGG GCTGTTGAAT GCCCCCCACC TCGGACCACA 
GCCAGGCTCC TTGATAAGCT TGTGGGAGAG TTCCTCGAAG TGACATGCAT CAGCCCTACA 
TTCATCTGTG ATCACCCACA GATCATGAGT CCTCTGGCCA AATGGCACCG TTGCAAAGAG 
GGTCTAACTG AGCGCTTCGA GCTGTTTGTC ATGAAGAAGG AAATATGCAA TGCGTACACT 
GAGCTGAACG ACCCCGTGCG GCAGAGACAA CTGTTTGAAG AACAGGCCAA GGCCAAGGCT 
GCTGGTGACG ATGAGGCCAT GTTCATAGAT GAGAACTTCT GTACTGCCCT GGAGTACGGG 
CTGCCCCCAA CAGCTGGCTG GGGCATGGGT ATCGACCGAG TCACCATGTT TCTCACAGAC 
TCCAACAATA TCAAGGAAGT ACTTCTCTTT CCTGCCATGA AGCCTGAAGA CAAGAAGGAA 
ACTGCAACAG CCACCGAGAC CCCAGAAAGC ACAGAGGCCA GCCCCTCTGT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression profile of aminoacyl-tRNA synthetases in dorsal root ganglion neurons after peripheral nerve injury.
Journal of molecular histology46(1)115-22(2015 Feb)
Park BS,Jo HW,Jung J

Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction.
Nature chemical biology10(1)29-34(2014 Jan)
Kim DG,Lee JY,Kwon NH,Fang P,Zhang Q,Wang J,Young NL,Guo M,Cho HY,Mushtaq AU,Jeon YH,Choi JW,Han JM,Kang HW,Joo JE,Hur Y,Kang W,Yang H,Nam DH,Lee MS,Lee JW,Kim ES,Moon A,Kim K,Kim D,Kang EJ,Moon Y,Rhee KH,Han BW,Yang JS,Han G,Yang WS,Lee C,Wang MW,Kim S

Structural switch of lysyl-tRNA synthetase between translation and transcription.
Molecular cell49(1)30-42(2013 Jan)
Ofir-Birin Y,Fang P,Bennett SP,Zhang HM,Wang J,Rachmin I,Shapiro R,Song J,Dagan A,Pozo J,Kim S,Marshall AG,Schimmel P,Yang XL,Nechushtan H,Razin E,Guo M

Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex.
Proceedings of the National Academy of Sciences of the United States of America108(20)8239-44(2011 May)
Fang P,Zhang HM,Shapiro R,Marshall AG,Schimmel P,Yang XL,Guo M

LysRS serves as a key signaling molecule in the immune response by regulating gene expression.
Molecular cell34(5)603-11(2009 Jun)
Yannay-Cohen N,Carmi-Levy I,Kay G,Yang CM,Han JM,Kemeny DM,Kim S,Nechushtan H,Razin E

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Kars cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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