Phex cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Phex
Entrez Gene ID	25512
Full Name	phosphate regulating endopeptidase homolog, X-linked
Synonyms	PEX
General protein information	Preferred Names phosphate regulating endopeptidase homolog, X-linked Names phosphate-regulating neutral endopeptidase Phosphate regulating neutral endopeptidase on the X chromosome (X-linked hypophosphatemia XLH) metalloendopeptidase homolog PEX phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq21
Summary	may play a role in the regulation of Pi homeostasis; may mediate mineralization process in the bone; mutations in human cause X-linked hypophosphatemia (XLH), a renal phosphate (Pi)-wasting disorder with defective bonemineralization [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013004.1	NP_037136.1	phosphate-regulating neutral endopeptidase

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PHEX	XP_003317428.1
Canis lupus familiaris (dog)	PHEX	XP_005641253.1
Gallus gallus (chicken)	PHEX	NP_001186206.1
Xenopus tropicalis (tropical clawed frog)	phex	XP_004911718.1
Homo sapiens (human)	PHEX	NP_000435.3
Mus musculus (house mouse)	Phex	NP_035207.1
Bos taurus (cattle)	PHEX	NP_001179800.2
Danio rerio (zebrafish)	phex	NP_001082818.1
Macaca mulatta (Rhesus monkey)	PHEX	XP_001087261.1
Rattus norvegicus (Norway rat)	Phex	NP_037136.1

Gene Ontology
Bibliography

Related articles in PubMed

Osteopetrosis, osteopetrorickets and hypophosphatemic rickets differentially affect dentin and enamel mineralization.
Koehne T, Marshall RP, Jeschke A, Kahl-Nieke B, Schinke T, Amling M
Bone53(1)25-33(2013 Mar)

A novel Phex mutation in a new mouse model of hypophosphatemic rickets.
Owen C, Chen F, Flenniken AM, Osborne LR, Ichikawa S, Adamson SL, Rossant J, Aubin JE
Journal of cellular biochemistry113(7)2432-41(2012 Jul)

PTHrP(1-34)-mediated repression of the PHEX gene in osteoblastic cells involves the transcriptional repressor E4BP4.
Pellicelli M, Taheri M, St-Louis M, Bériault V, Desgroseillers L, Boileau G, Moreau A
Journal of cellular physiology227(6)2378-87(2012 Jun)

A mouse model with postnatal endolymphatic hydrops and hearing loss.
Megerian CA, Semaan MT, Aftab S, Kisley LB, Zheng QY, Pawlowski KS, Wright CG, Alagramam KN
Hearing research237(1-2)90-105(2008 Mar)

The role of tumor necrosis factor alpha in down-regulation of osteoblast Phex gene expression in experimental murine colitis.
Uno JK, Kolek OI, Hines ER, Xu H, Timmermann BN, Kiela PR, Ghishan FK
Gastroenterology131(2)497-509(2006 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Phex gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Phex cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01622	NM_013004.1 Latest version!	Rattus norvegicus phosphate regulating endopeptidase homolog, X-linked (Phex), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Phex ( NM_013004.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037136.1 Rattus norvegicus phosphate regulating endopeptidase homolog, X-linked (Phex), mRNA.

Price & Availability↑

CloneID	ORa01622
Clone ID Related Accession (Same CDS sequence)	NM_013004.1
Accession Version	NM_013004.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2250bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1555516800000
Organism	Rattus norvegicus(Norway rat)
Product	phosphate-regulating neutral endopeptidase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ001637.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ001637.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689599, SAMEA2689601 [ECO:0000348] ##Evidence-Data-END##

ATGGAAGCAG AAGCAGGGAG CACCATGGAG ACTGGAAAGG GGACCAACCG AGGCATTCGG 
ATTGCACTGG CCCTGTTCAT TACTGGCACC CTGGTGCTGG GCACACTGCT CTTTCTAGTG 
AGTCAAGGTC TCCTAAGTTT CCAAGCTAAA CAGGAGTACT GCCTGAAGCC AGAATGCATT 
GAAGCCGCTG CTGCCATCAT GAGCAAAGTA AATCTTTCTG TGGATCCTTG TGAGAATTTT 
TTCCGGTTTG CTTGTGATGG CTGGATAAGC AATAACCCAA TTCCTGAAGA TATGCCAAGC 
TATGGGGTTT ATCCTTGGCT GAGACACAAT GTTGACCTCA AGTTGAAGGC ACTTCTGGAG 
AAATCAGTCA GTCGAAGGCG GGACACTGAA GCTGTACAGA AAGCCAAAAT CCTTTATTCA 
TCCTGCATGA ATGAGAAAGC GATTGAAAAA GCAGATGCCA AACCACTGCT CCACATCTTG 
AGGCATTCAC CTTTCCGCTG GCCCGTGCTT GAAGCTAATA TTGGTCCTGA AGGGGTTTGG 
TCAGAGAGAA AATTCAGTTT ACTGCAAACA CTGGCAACAT TCCGCGGTCA ATACAGCAAT 
TCTGTGTTCA TCCGTTTGTA CGTGTCCCCT GACGACAAGG CATCCAATGA GCATATCTTG 
AAGTTGGACC AAGCAACACT CTCCCTGGCT GTGAGGGAAG ACTTTCTGGA TAACACTACC 
GAAGCCAAAT CTTATCGTGA TGCCCTTTAC AAATTCATGG TGGACACTGC TGTGCTTTTA 
GGAGCTAATA GCTCTCGAGC TGAACATGAC ATGAAGTCAG TGCTTAGACT GGAAATTAAG 
ATAGCTGAGA TAATGATTCC ACATGAGAAC CGAACCAGTG AGGCTATGTA TAACAAAATG 
AACATCTCAG AGCTCAGTGC TATGATTCCC CAGTTTGACT GGCTGGGCTA TATCAAGAAG 
GTCATTGATA CCAGACTCTA CCCACACTTG AAAGACATTG GCCCCTCGGA GAATGTGGTG 
GTGCGCGTCC CACAATACTT TAAAGATTTG TTTAGGATAT TAGGTGCTGA AAGGAAGAAA 
ACCATTGCCA ACTATTTGGT GTGGAGAATG GTTTATTCCA GAATTCCAAA CCTCAGCAGG 
CGCTTTCAAT ATAGATGGCT GGAATTCTCA AGGGTAATCC AGGGGACAAC AACTCTGCTG 
CCTCAGTGGG ACAAATGTGT TAACTTTATC GAAAGTGCCC TCCCTTATGT TGTGGGGAAA 
ATGTTTGTGA ATGTTCACTT CCAGGAAGAT AAGAAGGAAA TGATGGAAGA ATTGATTGAG 
GGTGTTCGCT GGGCCTTCAT TGACATGCTG GAGAAAGAAA ATGAATGGAT GGATGCAGGG 
ACAAAAAGGA AAGCTCAAGA AAAGGCAAGA GCTGTTTTGG CAAAAGTTGG CTATCCAGAG 
TTTATAATGA ATGATACTTA TGTTAATGAA GACCTCAAGG CAATCAAATT TTCAGAATCG 
GACTACTTTG GCAACGTACT GCAAACCCGC AAGTATTTAG CACAGTCTGA TTTCTTCTGG 
CTAAAAAAAG CTGTTCCCAA AACAGAGTGG TTTACAAACC CAACAACGGT CAATGCCTTT 
TACAGTGCAT CTACCAACCA AATACGATTT CCTGCTGGAG AGCTGCAGAA GCCTTTCTTT 
TGGGGAACAG AATACCCTCG ATCTCTGAGT TACGGTGCTA TAGGAGTAAT TGTGGGGCAC 
GAATTTACAC ATGGATTTGA TAATAATGGT AGAAAATATG ATAAAAATGG AAACCTTGAT 
CCGTGGTGGT CTGTGGACTC TGAAGAAAAG TTTAAGGAAA AAACAAAATG CATGATTAAC 
CAGTATAGCA ACTATTATTG GAAGAAAGCC GGCTTAAATG TGAAGGGGAA AAGGACCTTG 
GGAGAAAATA TTGCTGATAA TGGAGGTCTT CGAGAAGCTT TTAGGGCTTA CAGGAAATGG 
ATAAATGATA GAAGACAGGG AGTTGAAGAG CCCCTCCTAC CAGGCATCAC ATTCACCAAC 
AATCAGCTCT TCTTCCTGAG TTATGCTCAC GTGAGGTGCA ATTCCTACAG ACCGGAAGCT 
GCCAGAGAAC AAGTCCAAAT TGGTGCTCAC AGTCCTCCAC AATTTAGAGT CAATGGTGCC 
ATTAGCAACT TTGAAGAATT TCAGAAAGCT TTTAACTGTC CGGCAAATTC CACCATGAAC 
AGAGGTGCAG ATTCCTGCCG ACTCTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037136.1
CDS	482..2731
Translation	MEAEAGSTMETGKGTNRGIRIALALFITGTLVLGTLLFLVSQGLLSFQAKQEYCLKPECIEAAAAIMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKALLEKSVSRRRDTEAVQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDFLDNTTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDIGPSENVVVRVPQYFKDLFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKARAVLAKVGYPEFIMNDTYVNEDLKAIKFSESDYFGNVLQTRKYLAQSDFFWLKKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSVDSEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGVEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPANSTMNRGADSCRLW

Target ORF information:

RefSeq Version	NM_013004.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus phosphate regulating endopeptidase homolog, X-linked (Phex), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013004.1

ORF Insert Sequence:

ATGGAAGCAG AAGCAGGGAG CACCATGGAG ACTGGAAAGG GGACCAACCG AGGCATTCGG 
ATTGCACTGG CCCTGTTCAT TACTGGCACC CTGGTGCTGG GCACACTGCT CTTTCTAGTG 
AGTCAAGGTC TCCTAAGTTT CCAAGCTAAA CAGGAGTACT GCCTGAAGCC AGAATGCATT 
GAAGCCGCTG CTGCCATCAT GAGCAAAGTA AATCTTTCTG TGGATCCTTG TGAGAATTTT 
TTCCGGTTTG CTTGTGATGG CTGGATAAGC AATAACCCAA TTCCTGAAGA TATGCCAAGC 
TATGGGGTTT ATCCTTGGCT GAGACACAAT GTTGACCTCA AGTTGAAGGC ACTTCTGGAG 
AAATCAGTCA GTCGAAGGCG GGACACTGAA GCTGTACAGA AAGCCAAAAT CCTTTATTCA 
TCCTGCATGA ATGAGAAAGC GATTGAAAAA GCAGATGCCA AACCACTGCT CCACATCTTG 
AGGCATTCAC CTTTCCGCTG GCCCGTGCTT GAAGCTAATA TTGGTCCTGA AGGGGTTTGG 
TCAGAGAGAA AATTCAGTTT ACTGCAAACA CTGGCAACAT TCCGCGGTCA ATACAGCAAT 
TCTGTGTTCA TCCGTTTGTA CGTGTCCCCT GACGACAAGG CATCCAATGA GCATATCTTG 
AAGTTGGACC AAGCAACACT CTCCCTGGCT GTGAGGGAAG ACTTTCTGGA TAACACTACC 
GAAGCCAAAT CTTATCGTGA TGCCCTTTAC AAATTCATGG TGGACACTGC TGTGCTTTTA 
GGAGCTAATA GCTCTCGAGC TGAACATGAC ATGAAGTCAG TGCTTAGACT GGAAATTAAG 
ATAGCTGAGA TAATGATTCC ACATGAGAAC CGAACCAGTG AGGCTATGTA TAACAAAATG 
AACATCTCAG AGCTCAGTGC TATGATTCCC CAGTTTGACT GGCTGGGCTA TATCAAGAAG 
GTCATTGATA CCAGACTCTA CCCACACTTG AAAGACATTG GCCCCTCGGA GAATGTGGTG 
GTGCGCGTCC CACAATACTT TAAAGATTTG TTTAGGATAT TAGGTGCTGA AAGGAAGAAA 
ACCATTGCCA ACTATTTGGT GTGGAGAATG GTTTATTCCA GAATTCCAAA CCTCAGCAGG 
CGCTTTCAAT ATAGATGGCT GGAATTCTCA AGGGTAATCC AGGGGACAAC AACTCTGCTG 
CCTCAGTGGG ACAAATGTGT TAACTTTATC GAAAGTGCCC TCCCTTATGT TGTGGGGAAA 
ATGTTTGTGA ATGTTCACTT CCAGGAAGAT AAGAAGGAAA TGATGGAAGA ATTGATTGAG 
GGTGTTCGCT GGGCCTTCAT TGACATGCTG GAGAAAGAAA ATGAATGGAT GGATGCAGGG 
ACAAAAAGGA AAGCTCAAGA AAAGGCAAGA GCTGTTTTGG CAAAAGTTGG CTATCCAGAG 
TTTATAATGA ATGATACTTA TGTTAATGAA GACCTCAAGG CAATCAAATT TTCAGAATCG 
GACTACTTTG GCAACGTACT GCAAACCCGC AAGTATTTAG CACAGTCTGA TTTCTTCTGG 
CTAAAAAAAG CTGTTCCCAA AACAGAGTGG TTTACAAACC CAACAACGGT CAATGCCTTT 
TACAGTGCAT CTACCAACCA AATACGATTT CCTGCTGGAG AGCTGCAGAA GCCTTTCTTT 
TGGGGAACAG AATACCCTCG ATCTCTGAGT TACGGTGCTA TAGGAGTAAT TGTGGGGCAC 
GAATTTACAC ATGGATTTGA TAATAATGGT AGAAAATATG ATAAAAATGG AAACCTTGAT 
CCGTGGTGGT CTGTGGACTC TGAAGAAAAG TTTAAGGAAA AAACAAAATG CATGATTAAC 
CAGTATAGCA ACTATTATTG GAAGAAAGCC GGCTTAAATG TGAAGGGGAA AAGGACCTTG 
GGAGAAAATA TTGCTGATAA TGGAGGTCTT CGAGAAGCTT TTAGGGCTTA CAGGAAATGG 
ATAAATGATA GAAGACAGGG AGTTGAAGAG CCCCTCCTAC CAGGCATCAC ATTCACCAAC 
AATCAGCTCT TCTTCCTGAG TTATGCTCAC GTGAGGTGCA ATTCCTACAG ACCGGAAGCT 
GCCAGAGAAC AAGTCCAAAT TGGTGCTCAC AGTCCTCCAC AATTTAGAGT CAATGGTGCC 
ATTAGCAACT TTGAAGAATT TCAGAAAGCT TTTAACTGTC CGGCAAATTC CACCATGAAC 
AGAGGTGCAG ATTCCTGCCG ACTCTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Osteopetrosis, osteopetrorickets and hypophosphatemic rickets differentially affect dentin and enamel mineralization.
Bone53(1)25-33(2013 Mar)
Koehne T,Marshall RP,Jeschke A,Kahl-Nieke B,Schinke T,Amling M

A novel Phex mutation in a new mouse model of hypophosphatemic rickets.
Journal of cellular biochemistry113(7)2432-41(2012 Jul)
Owen C,Chen F,Flenniken AM,Osborne LR,Ichikawa S,Adamson SL,Rossant J,Aubin JE

PTHrP(1-34)-mediated repression of the PHEX gene in osteoblastic cells involves the transcriptional repressor E4BP4.
Journal of cellular physiology227(6)2378-87(2012 Jun)
Pellicelli M,Taheri M,St-Louis M,Bériault V,Desgroseillers L,Boileau G,Moreau A

A mouse model with postnatal endolymphatic hydrops and hearing loss.
Hearing research237(1-2)90-105(2008 Mar)
Megerian CA,Semaan MT,Aftab S,Kisley LB,Zheng QY,Pawlowski KS,Wright CG,Alagramam KN

The role of tumor necrosis factor alpha in down-regulation of osteoblast Phex gene expression in experimental murine colitis.
Gastroenterology131(2)497-509(2006 Aug)
Uno JK,Kolek OI,Hines ER,Xu H,Timmermann BN,Kiela PR,Ghishan FK

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Phex cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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