Phex cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Phex
Entrez Gene ID	18675
Full Name	phosphate regulating endopeptidase homolog, X-linked
Synonyms	Gy,HPDR,HPDR1,Hyp,PEX
General protein information	Preferred Names phosphate regulating endopeptidase homolog, X-linked Names metalloendopeptidase homolog PEX Metalloendopeptidase homolog PEX (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein) X-linked hypophosphatemia protein X-linked phosphate regulating endopeptidase phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) phosphate regulating neutral endopeptidase vitamin D-resistant hypophosphatemic rickets protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X F4\|X 72.38 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_011077.2	NP_035207.1	phosphate-regulating neutral endopeptidase PHEX

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PHEX	XP_003317428.1
Canis lupus familiaris (dog)	PHEX	XP_005641253.1
Gallus gallus (chicken)	PHEX	NP_001186206.1
Xenopus tropicalis (tropical clawed frog)	phex	XP_004911718.1
Homo sapiens (human)	PHEX	NP_000435.3
Mus musculus (house mouse)	Phex	NP_035207.1
Bos taurus (cattle)	PHEX	NP_001179800.2
Danio rerio (zebrafish)	phex	NP_001082818.1
Macaca mulatta (Rhesus monkey)	PHEX	XP_001087261.1
Rattus norvegicus (Norway rat)	Phex	NP_037136.1

Gene Ontology
Bibliography

Related articles in PubMed

Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling.
Yorgan TA, Peters S, Amling M, Schinke T
Bone127155-163(2019 Oct)

Letter to the Editor: "Increased Circulating FGF23 Does Not Lead to Cardiac Hypertrophy in the Male Hyp Mouse Model of XLH".
Han X, Quarles LD
Endocrinology159(11)3655-3656(2018 11)

Cardiovascular Interactions between Fibroblast Growth Factor-23 and Angiotensin II.
Pi M, Ye R, Han X, Armstrong B, Liu X, Chen Y, Sun Y, Quarles LD
Scientific reports8(1)12398(2018 08)

Eldecalcitol Causes FGF23 Resistance for Pi Reabsorption and Improves Rachitic Bone Phenotypes in the Male Hyp Mouse.
Kaneko I, Segawa H, Ikuta K, Hanazaki A, Fujii T, Tatsumi S, Kido S, Hasegawa T, Amizuka N, Saito H, Miyamoto KI
Endocrinology159(7)2741-2758(2018 07)

The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk.
Pastor-Arroyo EM, Gehring N, Krudewig C, Costantino S, Bettoni C, Knöpfel T, Sabrautzki S, Lorenz-Depiereux B, Pastor J, Strom TM, Hrabě de Angelis M, Camici GG, Paneni F, Wagner CA, Rubio-Aliaga I
Kidney international94(1)49-59(2018 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Phex gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Phex cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu23529	NM_011077.2 Latest version!	Mus musculus phosphate regulating endopeptidase homolog, X-linked (Phex), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Phex ( NM_011077.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035207.1 Mus musculus phosphate regulating endopeptidase homolog, X-linked (Phex), mRNA.

Price & Availability↑

CloneID	OMu23529
Clone ID Related Accession (Same CDS sequence)	NM_011077.2
Accession Version	NM_011077.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2250bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1576425600000
Organism	Mus musculus(house mouse)
Product	phosphate-regulating neutral endopeptidase PHEX
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK158481.1, U49908.1 and CT572987.3. On Oct 26, 2006 this sequence version replaced NM_011077.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U49908.1, AK158481.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGAAGCAG AAACAGGGAG CACCATGGAG ACTGGAAAGG GGACCAACCG AGGCATTCGG 
ATTGCACTGG CCCTGTTTAT TGGTGGCACC CTGGTGTTGG GCACACTGCT CTTTCTAGTG 
AGTCAAGGTC TCCTAAGTTT CCAAGCTAAA CAGGAGTACT GTCTGAAGCC AGAATGCATA 
GAAGCCGCTG CTGCCATCAT GAGCAAAGTA AATCTTTCTG TGGATCCTTG TGAGAATTTT 
TTCCGGTTTG CTTGTGATGG CTGGATAAGC AATAACCCAA TTCCTGAAGA TATGCCAAGC 
TATGGGGTTT ATCCTTGGCT GAGACACAAT GTTGACCTCA AGTTGAAGGC ACTTCTGGAG 
AAATCAGTCA GCCGAAGGCG GGACACTGAA GCCGTACAGA AAGCCAAAAT CCTCTACTCA 
TCCTGCATGA ATGAGAAAGC AATTGAAAAA GCAGATGCCA AGCCACTGCT CCACATCTTG 
AGGCATTCAC CTTTCCGCTG GCCAGTGCTT GAAGCTAATA TTGGTCCTGA AGGGGTTTGG 
TCAGAGAGAA AATTCAGTCT ACTGCAAACA CTGGCAACGT TCCGCGGTCA ATACAGCAAT 
TCTGTGTTCA TCCGTTTGTA TGTGTCCCCT GATGACAAGG CATCCAATGA ACATATCTTG 
AAGCTGGACC AAGCAACACT CTCTCTGGCT GTAAGGGAAG ACTTCCTGGA TAACACTACT 
GAAGCCAAAT CTTATCGGGA TGCCCTTTAC AAATTCATGG TGGACACTGC TGTGCTTTTA 
GGAGCTAATA GCTCTCGAGC TGAACATGAC ATGAAGTCGG TGCTTAGACT GGAAATTAAG 
ATAGCTGAGA TAATGATTCC ACATGAGAAC CGAACCAGTG AGGCTATGTA TAACAAAATG 
AACATCTCAG AACTCAGCGC TATGATTCCC CAGTTTGACT GGCTGGGCTA TATCAAGAAG 
GTCATTGATA CCAGACTCTA CCCACACTTG AAAGACATTG GTCCCTCGGA GAATGTGGTG 
GTCCGCGTCC CACAGTACTT TAAAGATTTG TTTAGGATAT TAGGTGCCGA GAGGAAGAAA 
ACCATTGCCA ATTATTTAGT GTGGAGAATG GTTTATTCCA GAATTCCAAA CCTCAGCAGG 
CGCTTTCAAT ATAGATGGCT AGAATTCTCA AGGGTAATCC AGGGGACCAC AACTCTGCTG 
CCTCAGTGGG ACAAATGTGT CAACTTTATT GAGAGTGCAC TCCCATATGT TGTGGGGAAA 
ATGTTTGTGA ATGTTCACTT CCAGGAGGAT AAGAAGGAAA TGATGGAAGA ATTGATTGAG 
GGTGTTCGCT GGGCCTTCAT TGACATGCTG GAGAAAGAAA ATGAATGGAT GGATGCAGGG 
ACAAAAAGGA AAGCTCAAGA AAAGGCAAGA GCTGTTTTGG CAAAAGTTGG CTATCCAGAG 
TTTATAATGA ATGATACTTA TGTTAATGAA GACCTCAAGG CAATCAAATT TTCAGAATCG 
GACTACTTTG GCAACGTACT GCAAACCCGC AAGTATTTAG CACAGTCTGA TTTCTTCTGG 
CTAAGAAAAG CTGTTCCCAA AACAGAGTGG TTTACAAACC CAACAACAGT CAATGCCTTT 
TACAGTGCAT CTACCAACCA GATACGATTT CCTGCTGGAG AGCTGCAGAA GCCTTTCTTT 
TGGGGAACAG AATACCCTCG ATCCCTGAGT TATGGTGCTA TAGGAGTAAT TGTGGGCCAT 
GAATTTACAC ATGGATTTGA TAATAATGGT AGAAAATATG ATAAAAATGG AAACCTTGAT 
CCGTGGTGGT CTGTGGAATC AGAAGAAAAG TTTAAGGAAA AAACAAAATG CATGATTAAC 
CAGTATAGCA ACTATTATTG GAAGAAAGCC GGCTTAAATG TGAAAGGGAA GAGGACCCTG 
GGAGAAAATA TTGCTGATAA TGGGGGTCTG CGAGAAGCTT TTAGGGCTTA CAGGAAATGG 
ATAAATGATA GAAGACAGGG AGTTGAAGAG CCCCTCCTAC CAGGCATCAC ATTCACCAAC 
AATCAGCTCT TCTTCCTGAG TTATGCTCAT GTAAGGTGCA ATTCCTATAG ACCAGAAGCT 
GCCAGAGAAC AAGTGCAAAT TGGTGCTCAC AGTCCTCCAC AATTTAGGGT CAATGGTGCC 
ATTAGCAACT TTGAAGAATT TCAGAAAGCT TTTAACTGTC CACGAAATTC CACTATGAAC 
AGAGGTGCAG ATTCCTGCCG ACTCTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035207.1
CDS	531..2780
Translation	MEAETGSTMETGKGTNRGIRIALALFIGGTLVLGTLLFLVSQGLLSFQAKQEYCLKPECIEAAAAIMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKALLEKSVSRRRDTEAVQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDFLDNTTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDIGPSENVVVRVPQYFKDLFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKARAVLAKVGYPEFIMNDTYVNEDLKAIKFSESDYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSVESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGVEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPRNSTMNRGADSCRLW

Target ORF information:

RefSeq Version	NM_011077.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus phosphate regulating endopeptidase homolog, X-linked (Phex), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011077.2

ORF Insert Sequence:

ATGGAAGCAG AAACAGGGAG CACCATGGAG ACTGGAAAGG GGACCAACCG AGGCATTCGG 
ATTGCACTGG CCCTGTTTAT TGGTGGCACC CTGGTGTTGG GCACACTGCT CTTTCTAGTG 
AGTCAAGGTC TCCTAAGTTT CCAAGCTAAA CAGGAGTACT GTCTGAAGCC AGAATGCATA 
GAAGCCGCTG CTGCCATCAT GAGCAAAGTA AATCTTTCTG TGGATCCTTG TGAGAATTTT 
TTCCGGTTTG CTTGTGATGG CTGGATAAGC AATAACCCAA TTCCTGAAGA TATGCCAAGC 
TATGGGGTTT ATCCTTGGCT GAGACACAAT GTTGACCTCA AGTTGAAGGC ACTTCTGGAG 
AAATCAGTCA GCCGAAGGCG GGACACTGAA GCCGTACAGA AAGCCAAAAT CCTCTACTCA 
TCCTGCATGA ATGAGAAAGC AATTGAAAAA GCAGATGCCA AGCCACTGCT CCACATCTTG 
AGGCATTCAC CTTTCCGCTG GCCAGTGCTT GAAGCTAATA TTGGTCCTGA AGGGGTTTGG 
TCAGAGAGAA AATTCAGTCT ACTGCAAACA CTGGCAACGT TCCGCGGTCA ATACAGCAAT 
TCTGTGTTCA TCCGTTTGTA TGTGTCCCCT GATGACAAGG CATCCAATGA ACATATCTTG 
AAGCTGGACC AAGCAACACT CTCTCTGGCT GTAAGGGAAG ACTTCCTGGA TAACACTACT 
GAAGCCAAAT CTTATCGGGA TGCCCTTTAC AAATTCATGG TGGACACTGC TGTGCTTTTA 
GGAGCTAATA GCTCTCGAGC TGAACATGAC ATGAAGTCGG TGCTTAGACT GGAAATTAAG 
ATAGCTGAGA TAATGATTCC ACATGAGAAC CGAACCAGTG AGGCTATGTA TAACAAAATG 
AACATCTCAG AACTCAGCGC TATGATTCCC CAGTTTGACT GGCTGGGCTA TATCAAGAAG 
GTCATTGATA CCAGACTCTA CCCACACTTG AAAGACATTG GTCCCTCGGA GAATGTGGTG 
GTCCGCGTCC CACAGTACTT TAAAGATTTG TTTAGGATAT TAGGTGCCGA GAGGAAGAAA 
ACCATTGCCA ATTATTTAGT GTGGAGAATG GTTTATTCCA GAATTCCAAA CCTCAGCAGG 
CGCTTTCAAT ATAGATGGCT AGAATTCTCA AGGGTAATCC AGGGGACCAC AACTCTGCTG 
CCTCAGTGGG ACAAATGTGT CAACTTTATT GAGAGTGCAC TCCCATATGT TGTGGGGAAA 
ATGTTTGTGA ATGTTCACTT CCAGGAGGAT AAGAAGGAAA TGATGGAAGA ATTGATTGAG 
GGTGTTCGCT GGGCCTTCAT TGACATGCTG GAGAAAGAAA ATGAATGGAT GGATGCAGGG 
ACAAAAAGGA AAGCTCAAGA AAAGGCAAGA GCTGTTTTGG CAAAAGTTGG CTATCCAGAG 
TTTATAATGA ATGATACTTA TGTTAATGAA GACCTCAAGG CAATCAAATT TTCAGAATCG 
GACTACTTTG GCAACGTACT GCAAACCCGC AAGTATTTAG CACAGTCTGA TTTCTTCTGG 
CTAAGAAAAG CTGTTCCCAA AACAGAGTGG TTTACAAACC CAACAACAGT CAATGCCTTT 
TACAGTGCAT CTACCAACCA GATACGATTT CCTGCTGGAG AGCTGCAGAA GCCTTTCTTT 
TGGGGAACAG AATACCCTCG ATCCCTGAGT TATGGTGCTA TAGGAGTAAT TGTGGGCCAT 
GAATTTACAC ATGGATTTGA TAATAATGGT AGAAAATATG ATAAAAATGG AAACCTTGAT 
CCGTGGTGGT CTGTGGAATC AGAAGAAAAG TTTAAGGAAA AAACAAAATG CATGATTAAC 
CAGTATAGCA ACTATTATTG GAAGAAAGCC GGCTTAAATG TGAAAGGGAA GAGGACCCTG 
GGAGAAAATA TTGCTGATAA TGGGGGTCTG CGAGAAGCTT TTAGGGCTTA CAGGAAATGG 
ATAAATGATA GAAGACAGGG AGTTGAAGAG CCCCTCCTAC CAGGCATCAC ATTCACCAAC 
AATCAGCTCT TCTTCCTGAG TTATGCTCAT GTAAGGTGCA ATTCCTATAG ACCAGAAGCT 
GCCAGAGAAC AAGTGCAAAT TGGTGCTCAC AGTCCTCCAC AATTTAGGGT CAATGGTGCC 
ATTAGCAACT TTGAAGAATT TCAGAAAGCT TTTAACTGTC CACGAAATTC CACTATGAAC 
AGAGGTGCAG ATTCCTGCCG ACTCTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling.
Bone127155-163(2019 Oct)
Yorgan TA,Peters S,Amling M,Schinke T

Letter to the Editor: "Increased Circulating FGF23 Does Not Lead to Cardiac Hypertrophy in the Male Hyp Mouse Model of XLH".
Endocrinology159(11)3655-3656(2018 11)
Han X,Quarles LD

Cardiovascular Interactions between Fibroblast Growth Factor-23 and Angiotensin II.
Scientific reports8(1)12398(2018 08)
Pi M,Ye R,Han X,Armstrong B,Liu X,Chen Y,Sun Y,Quarles LD

Eldecalcitol Causes FGF23 Resistance for Pi Reabsorption and Improves Rachitic Bone Phenotypes in the Male Hyp Mouse.
Endocrinology159(7)2741-2758(2018 07)
Kaneko I,Segawa H,Ikuta K,Hanazaki A,Fujii T,Tatsumi S,Kido S,Hasegawa T,Amizuka N,Saito H,Miyamoto KI

The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk.
Kidney international94(1)49-59(2018 07)
Pastor-Arroyo EM,Gehring N,Krudewig C,Costantino S,Bettoni C,Knöpfel T,Sabrautzki S,Lorenz-Depiereux B,Pastor J,Strom TM,Hrabě de Angelis M,Camici GG,Paneni F,Wagner CA,Rubio-Aliaga I

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Phex cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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