Hmgb4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hmgb4
Entrez Gene ID	69317
Full Name	high-mobility group box 4
Synonyms	1700001F22Rik,AI326135
General protein information	Preferred Names high-mobility group box 4 Names high mobility group protein B4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 D2.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_027036.3	NP_081312.2	high mobility group protein B4

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	LOC710554	XP_001107984.1
Homo sapiens (human)	HMGB4	NP_660206.2
Canis lupus familiaris (dog)	HMGB4	XP_851529.2
Mus musculus (house mouse)	Hmgb4	NP_081312.2
Bos taurus (cattle)	HMGB4	NP_001035652.1
Rattus norvegicus (Norway rat)	Hmgb4	NP_001102933.1
Pan troglodytes (chimpanzee)	HMGB4	XP_513298.3

Gene Ontology
Bibliography

Related articles in PubMed

CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†.
Lu Y, Oura S, Matsumura T, Oji A, Sakurai N, Fujihara Y, Shimada K, Miyata H, Tobita T, Noda T, Castaneda JM, Kiyozumi D, Zhang Q, Larasati T, Young SAM, Kodani M, Huddleston CA, Robertson MJ, Coarfa C, Isotani A, Aitken RJ, Okabe M, Matzuk MM, Garcia TX, Ikawa M
Biology of reproduction101(2)501-511(2019 Aug)

HMGB4 is expressed by neuronal cells and affects the expression of genes involved in neural differentiation.
Rouhiainen A, Zhao X, Vanttola P, Qian K, Kulesskiy E, Kuja-Panula J, Gransalke K, Grönholm M, Unni E, Meistrich M, Tian L, Auvinen P, Rauvala H
Scientific reports632960(2016 09)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

Binding interaction of HMGB4 with cisplatin-modified DNA.
Park S, Lippard SJ
Biochemistry51(34)6728-37(2012 Aug)

HMGB factors are required for posterior digit development through integrating signaling pathway activities.
Itou J, Taniguchi N, Oishi I, Kawakami H, Lotz M, Kawakami Y
Developmental dynamics : an official publication of the American Association of Anatomists240(5)1151-62(2011 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Hmgb4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hmgb4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14750	NM_027036.3 Latest version!	Mus musculus high-mobility group box 4 (Hmgb4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hmgb4 ( NM_027036.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081312.2 Mus musculus high-mobility group box 4 (Hmgb4), mRNA.

Price & Availability↑

CloneID	OMu14750
Clone ID Related Accession (Same CDS sequence)	NM_027036.3
Accession Version	NM_027036.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570377600000
Organism	Mus musculus(house mouse)
Product	high mobility group protein B4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN840046.1, BC061030.1 and CA465179.1. On May 23, 2007 this sequence version replaced NM_027036.2. ##Evidence-Data-START## Transcript is intronless :: BU938291.1, CA463434.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAAA AAGACCAGCT AAGGCCCAAG GTGAATGTGT CTTCTTACAT CCATTTTATG 
CTGAATTTCA GAAACAAATT CAAGGAGCAA CAGCCAAATA CCTACCTTGG CTTTAAAGAA 
TTCTCTAGAA AGTGTTCAGA AAAATGGAGA TCCATCTCAA AGCACGAAAA GGCAAAGTAT 
GAAGCCCTAG CAGAGCTCGA TAAAGCCCGG TACCAGCAAG AAATGATGAA TTACATAGGC 
AAGAGAAGAA AGAGAAGAAA GAGGGACCCA AAGGCACCGC GGAAGCCCCC ATCCTCCTTC 
CTGCTCTTCT CCCGGGACCA CTATGCTATG CTGAAGCAAG AGAACCCCGA CTGGACCGTG 
GTGCAGGTGG CCAAGGCTGC TGGGAAAATG TGGTCCACAA CTGACGAAGC AGAAAAAAAG 
CCCTATGAAC AGAAGGCTGC ACTTATGCGG GCAAAGTATT TCGAGGAACA GGAGGCCTAC 
CGCAACCAAT GTCAAGGCAG GAAGGGGAAT TTCTTGGAAT CAGCCAAGAC CAGTTTGAAA 
CAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081312.2
CDS	123..668
Translation	MGEKDQLRPKVNVSSYIHFMLNFRNKFKEQQPNTYLGFKEFSRKCSEKWRSISKHEKAKYEALAELDKARYQQEMMNYIGKRRKRRKRDPKAPRKPPSSFLLFSRDHYAMLKQENPDWTVVQVAKAAGKMWSTTDEAEKKPYEQKAALMRAKYFEEQEAYRNQCQGRKGNFLESAKTSLKQ

Target ORF information:

RefSeq Version	NM_027036.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus high-mobility group box 4 (Hmgb4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027036.3

ORF Insert Sequence:

ATGGGGGAAA AAGACCAGCT AAGGCCCAAG GTGAATGTGT CTTCTTACAT CCATTTTATG 
CTGAATTTCA GAAACAAATT CAAGGAGCAA CAGCCAAATA CCTACCTTGG CTTTAAAGAA 
TTCTCTAGAA AGTGTTCAGA AAAATGGAGA TCCATCTCAA AGCACGAAAA GGCAAAGTAT 
GAAGCCCTAG CAGAGCTCGA TAAAGCCCGG TACCAGCAAG AAATGATGAA TTACATAGGC 
AAGAGAAGAA AGAGAAGAAA GAGGGACCCA AAGGCACCGC GGAAGCCCCC ATCCTCCTTC 
CTGCTCTTCT CCCGGGACCA CTATGCTATG CTGAAGCAAG AGAACCCCGA CTGGACCGTG 
GTGCAGGTGG CCAAGGCTGC TGGGAAAATG TGGTCCACAA CTGACGAAGC AGAAAAAAAG 
CCCTATGAAC AGAAGGCTGC ACTTATGCGG GCAAAGTATT TCGAGGAACA GGAGGCCTAC 
CGCAACCAAT GTCAAGGCAG GAAGGGGAAT TTCTTGGAAT CAGCCAAGAC CAGTTTGAAA 
CAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†.
Biology of reproduction101(2)501-511(2019 Aug)
Lu Y,Oura S,Matsumura T,Oji A,Sakurai N,Fujihara Y,Shimada K,Miyata H,Tobita T,Noda T,Castaneda JM,Kiyozumi D,Zhang Q,Larasati T,Young SAM,Kodani M,Huddleston CA,Robertson MJ,Coarfa C,Isotani A,Aitken RJ,Okabe M,Matzuk MM,Garcia TX,Ikawa M

HMGB4 is expressed by neuronal cells and affects the expression of genes involved in neural differentiation.
Scientific reports632960(2016 09)
Rouhiainen A,Zhao X,Vanttola P,Qian K,Kulesskiy E,Kuja-Panula J,Gransalke K,Grönholm M,Unni E,Meistrich M,Tian L,Auvinen P,Rauvala H

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

Binding interaction of HMGB4 with cisplatin-modified DNA.
Biochemistry51(34)6728-37(2012 Aug)
Park S,Lippard SJ

HMGB factors are required for posterior digit development through integrating signaling pathway activities.
Developmental dynamics : an official publication of the American Association of Anatomists240(5)1151-62(2011 May)
Itou J,Taniguchi N,Oishi I,Kawakami H,Lotz M,Kawakami Y

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Hmgb4 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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