| Gene Symbol | Ahcy |
| Entrez Gene ID | 269378 |
| Full Name | S-adenosylhomocysteine hydrolase |
| Synonyms | AA987153,AL024110,CuBP,SAHH |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
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Ahcy cDNA ORF clone, Mus musculus(house mouse)
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Gene
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Clones
gRNAs
The following Ahcy gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ahcy cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu10370 Clone ID Related Accession (Same CDS sequence) NM_016661.3 Accession Version NM_016661.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1299bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1568995200000 Organism Mus musculus(house mouse) Product adenosylhomocysteinase Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BQ929555.1, AK169331.1, BC086781.1 and AA237720.1. On Oct 31, 2009 this sequence version replaced NM_016661.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC086781.1, BC108367.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261ATGTCTGATA AACTGCCCTA CAAAGTCGCG GACATCGGAC TGGCCGCCTG GGGACGGAAG
GCTCTGGATA TAGCTGAGAA TGAGATGCCA GGATTGATGC GCATGCGGGA GATGTACTCA
GCCTCCAAGC CACTGAAGGG TGCTCGCATT GCTGGCTGCC TGCACATGAC CGTGGAGACT
GCTGTTCTCA TTGAGACTCT CGTGGCCCTG GGTGCTGAGG TGCGGTGGTC CAGCTGCAAC
ATCTTCTCTA CTCAGGACCA TGCAGCGGCT GCCATTGCCA AGGCTGGCAT TCCAGTGTTT
GCCTGGAAGG GCGAGACAGA TGAGGAGTAC CTGTGGTGCA TTGAGCAGAC GCTGCACTTC
AAGGACGGAC CCCTCAACAT GATTCTGGAT GATGGTGGTG ACCTTACTAA CCTCATCCAC
ACCAAATACC CACAGCTTCT GTCAGGCATC CGAGGTATCT CTGAGGAGAC CACGACTGGG
GTCCACAACC TCTACAAGAT GATGTCCAAT GGGATACTGA AGGTGCCTGC CATCAATGTC
AACGATTCTG TCACCAAGAG CAAGTTTGAC AACCTCTATG GCTGCCGGGA GTCCCTCATA
GATGGCATCA AACGGGCCAC AGATGTGATG ATTGCGGGCA AGGTGGCGGT GGTGGCAGGC
TATGGTGATG TGGGCAAGGG CTGTGCCCAG GCCCTGAGGG GTTTTGGGGC CCGAGTCATC
ATCACCGAGA TCGACCCCAT CAATGCACTG CAAGCTGCCA TGGAGGGCTA TGAGGTAACC
ACTATGGACG AAGCCTGTAA GGAGGGCAAC ATCTTTGTCA CCACCACAGG CTGTGTGGAT
ATCATCCTTG GCCGGCACTT TGAGCAGATG AAGGATGACG CCATTGTCTG TAACATTGGA
CACTTCGATG TGGAGATTGA TGTGAAGTGG CTCAATGAGA ACGCGGTGGA GAAAGTGAAC
ATCAAGCCCC AGGTGGACCG CTACTGGCTA AAGAATGGGC GCCGCATCAT CTTGCTGGCT
GAAGGCCGTC TGGTCAACCT GGGTTGTGCC ATGGGACACC CCAGCTTCGT GATGAGCAAC
TCCTTCACAA ACCAGGTGAT GGCACAGATT GAGCTGTGGA CCCACCCAGA TAAATACCCT
GTTGGGGTTC ACTTCCTGCC TAAGAAGCTG GATGAGGCGG TGGCTGAAGC CCACCTGGGC
AAGCTGAATG TGAAGCTGAC CAAGCTGACT GAGAAGCAGG CCCAGTACCT GGGCATGCCC
ATCAACGGCC CCTTCAAGCC TGATCACTAC CGCTACTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_057870.3 CDS 106..1404 Translation 
Target ORF information:
RefSeq Version NM_016661.3 Organism Mus musculus(house mouse) Definition Mus musculus S-adenosylhomocysteine hydrolase (Ahcy), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_016661.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261ATGTCTGATA AACTGCCCTA CAAAGTCGCG GACATCGGAC TGGCCGCCTG GGGACGGAAG
GCTCTGGATA TAGCTGAGAA TGAGATGCCA GGATTGATGC GCATGCGGGA GATGTACTCA
GCCTCCAAGC CACTGAAGGG TGCTCGCATT GCTGGCTGCC TGCACATGAC CGTGGAGACT
GCTGTTCTCA TTGAGACTCT CGTGGCCCTG GGTGCTGAGG TGCGGTGGTC CAGCTGCAAC
ATCTTCTCTA CTCAGGACCA TGCAGCGGCT GCCATTGCCA AGGCTGGCAT TCCAGTGTTT
GCCTGGAAGG GCGAGACAGA TGAGGAGTAC CTGTGGTGCA TTGAGCAGAC GCTGCACTTC
AAGGACGGAC CCCTCAACAT GATTCTGGAT GATGGTGGTG ACCTTACTAA CCTCATCCAC
ACCAAATACC CACAGCTTCT GTCAGGCATC CGAGGTATCT CTGAGGAGAC CACGACTGGG
GTCCACAACC TCTACAAGAT GATGTCCAAT GGGATACTGA AGGTGCCTGC CATCAATGTC
AACGATTCTG TCACCAAGAG CAAGTTTGAC AACCTCTATG GCTGCCGGGA GTCCCTCATA
GATGGCATCA AACGGGCCAC AGATGTGATG ATTGCGGGCA AGGTGGCGGT GGTGGCAGGC
TATGGTGATG TGGGCAAGGG CTGTGCCCAG GCCCTGAGGG GTTTTGGGGC CCGAGTCATC
ATCACCGAGA TCGACCCCAT CAATGCACTG CAAGCTGCCA TGGAGGGCTA TGAGGTAACC
ACTATGGACG AAGCCTGTAA GGAGGGCAAC ATCTTTGTCA CCACCACAGG CTGTGTGGAT
ATCATCCTTG GCCGGCACTT TGAGCAGATG AAGGATGACG CCATTGTCTG TAACATTGGA
CACTTCGATG TGGAGATTGA TGTGAAGTGG CTCAATGAGA ACGCGGTGGA GAAAGTGAAC
ATCAAGCCCC AGGTGGACCG CTACTGGCTA AAGAATGGGC GCCGCATCAT CTTGCTGGCT
GAAGGCCGTC TGGTCAACCT GGGTTGTGCC ATGGGACACC CCAGCTTCGT GATGAGCAAC
TCCTTCACAA ACCAGGTGAT GGCACAGATT GAGCTGTGGA CCCACCCAGA TAAATACCCT
GTTGGGGTTC ACTTCCTGCC TAAGAAGCTG GATGAGGCGG TGGCTGAAGC CCACCTGGGC
AAGCTGAATG TGAAGCTGAC CAAGCTGACT GAGAAGCAGG CCCAGTACCT GGGCATGCCC
ATCAACGGCC CCTTCAAGCC TGATCACTAC CGCTACTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology32(3)1591-1601(2018 03)
Pogribny IP,Dreval K,Kindrat I,Melnyk S,Jimenez L,de Conti A,Tryndyak V,Pogribna M,Ortega JF,James SJ,Rusyn I,Beland FA
High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bućan M,Murray SA
H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase.
Nature communications610221(2015 Dec)
Zhou J,Yang L,Zhong T,Mueller M,Men Y,Zhang N,Xie J,Giang K,Chung H,Sun X,Lu L,Carmichael GG,Taylor HS,Huang Y
Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet.
Molecular nutrition & food research55(3)411-8(2011 Mar)
Tryndyak VP,Han T,Muskhelishvili L,Fuscoe JC,Ross SA,Beland FA,Pogribny IP
Crystallization of mouse S-adenosyl-L-homocysteine hydrolase.
Acta crystallographica. Section F, Structural biology and crystallization communications66(Pt 3)313-5(2010 Mar)
Ishihara M,Kusakabe Y,Ohsumichi T,Tanaka N,Nakanishi M,Kitade Y,Nakamura KT
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