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About the Signalling by NGF pathway
Neurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in minute amounts, by a variety of tissues.
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| Gene Symbol | Full Name |
|---|---|
| ABR | active BCR-related |
| ACTN2 | actinin, alpha 2 |
| ADCY1 | adenylate cyclase 1 (brain) |
| ADCY2 | adenylate cyclase 2 (brain) |
| ADCY3 | adenylate cyclase 3 |
| ADCY5 | adenylate cyclase 5 |
| ADCY6 | adenylate cyclase 6 |
| ADCY7 | adenylate cyclase 7 |
| ADCY8 | adenylate cyclase 8 (brain) |
| ADCY9 | adenylate cyclase 9 |
| ADCYAP1 | adenylate cyclase activating polypeptide 1 (pituitary) |
| ADCYAP1R1 | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I |
| ADORA2A | adenosine A2a receptor |
| ADRBK1 | adrenergic, beta, receptor kinase 1 |
| AP2A1 | adaptor-related protein complex 2, alpha 1 subunit |
| AP2A2 | adaptor-related protein complex 2, alpha 2 subunit |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 |
| ANGPT1 | angiopoietin 1 |
| ARAF | A-Raf proto-oncogene, serine/threonine kinase |
| RHOA | ras homolog family member A |
| ARHGAP4 | Rho GTPase activating protein 4 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha |
| ARRB1 | arrestin, beta 1 |
| ARRB2 | arrestin, beta 2 |
| ATF1 | activating transcription factor 1 |
| BAD | BCL2-associated agonist of cell death |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase |
| BTC | betacellulin |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) |
| CALM3 | calmodulin 3 (phosphorylase kinase, delta) |
| CAMK4 | calcium/calmodulin-dependent protein kinase IV |
| CAMK2A | calcium/calmodulin-dependent protein kinase II alpha |
| CAMK2B | calcium/calmodulin-dependent protein kinase II beta |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta |
| CAMK2G | calcium/calmodulin-dependent protein kinase II gamma |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase |
| CD19 | CD19 molecule |
| CD28 | CD28 molecule |
| CD80 | CD80 molecule |
| CD86 | CD86 molecule |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
| CHUK | conserved helix-loop-helix ubiquitous kinase |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit |
| AP2S1 | adaptor-related protein complex 2, sigma 1 subunit |
| CLTA | clathrin, light chain A |
| CREB1 | cAMP responsive element binding protein 1 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog |
| CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like |
| MAPK14 | mitogen-activated protein kinase 14 |
| CSF2 | colony stimulating factor 2 (granulocyte-macrophage) |
| CSF2RA | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) |
| CSK | c-src tyrosine kinase |
| DLG4 | discs, large homolog 4 (Drosophila) |
| DNM1 | dynamin 1 |
| DNM2 | dynamin 2 |
| HBEGF | heparin-binding EGF-like growth factor |
| DUSP1 | dual specificity phosphatase 1 |
| DUSP2 | dual specificity phosphatase 2 |
| DUSP3 | dual specificity phosphatase 3 |
| DUSP4 | dual specificity phosphatase 4 |
| DUSP5 | dual specificity phosphatase 5 |
| DUSP6 | dual specificity phosphatase 6 |
| DUSP7 | dual specificity phosphatase 7 |
| DUSP8 | dual specificity phosphatase 8 |
| DUSP9 | dual specificity phosphatase 9 |
| ECT2 | epithelial cell transforming 2 |
| EGF | epidermal growth factor |
| EGFR | epidermal growth factor receptor |
| ELK1 | ELK1, member of ETS oncogene family |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 |
| EREG | epiregulin |
| FGA | fibrinogen alpha chain |
| FGB | fibrinogen beta chain |
| FGD1 | FYVE, RhoGEF and PH domain containing 1 |
| FGF1 | fibroblast growth factor 1 (acidic) |
| FGF2 | fibroblast growth factor 2 (basic) |
| FGF3 | fibroblast growth factor 3 |
| FGF4 | fibroblast growth factor 4 |
| FGF5 | fibroblast growth factor 5 |
| FGF6 | fibroblast growth factor 6 |
| FGF7 | fibroblast growth factor 7 |
| FGF8 | fibroblast growth factor 8 (androgen-induced) |
| FGF9 | fibroblast growth factor 9 |
| FGF10 | fibroblast growth factor 10 |
| FGFR1 | fibroblast growth factor receptor 1 |
| FGFR3 | fibroblast growth factor receptor 3 |
| FGFR2 | fibroblast growth factor receptor 2 |
| FGFR4 | fibroblast growth factor receptor 4 |
| FGG | fibrinogen gamma chain |
| FOXO1 | forkhead box O1 |
| FOXO3 | forkhead box O3 |