Gucy2c cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gucy2c
Entrez Gene ID	14917
Full Name	guanylate cyclase 2c
Synonyms	AI893437,GC-C,Gcc
General protein information	Preferred Names guanylate cyclase 2c Names heat-stable enterotoxin receptor STA receptor guanylyl cyclase C intestinal guanylate cyclase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 G1\|6 66.67 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_145067.3	NP_659504.2	heat-stable enterotoxin receptor isoform 2 precursor
NM_001127318.1	NP_001120790.1	heat-stable enterotoxin receptor isoform 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GUCY2C	XP_528746.2
Macaca mulatta (Rhesus monkey)	GUCY2C	XP_001089601.1
Danio rerio (zebrafish)	LOC568219	XP_696628.4
Homo sapiens (human)	GUCY2C	NP_004954.2
Bos taurus (cattle)	GUCY2C	NP_776972.1
Mus musculus (house mouse)	Gucy2c	NP_001120790.1
Rattus norvegicus (Norway rat)	Gucy2c	NP_037302.1
Xenopus tropicalis (tropical clawed frog)	gucy2c	XP_002934756.1
Canis lupus familiaris (dog)	GUCY2C	XP_543798.3
Danio rerio (zebrafish)	LOC572052	XP_700803.6
Gallus gallus (chicken)	GUCY2C	XP_416207.3

Gene Ontology
Bibliography

Related articles in PubMed

TCR Retrogenic Mice as a Model To Map Self-Tolerance Mechanisms to the Cancer Mucosa Antigen GUCY2C.
Abraham TS, Flickinger JC Jr, Waldman SA, Snook AE
Journal of immunology (Baltimore, Md. : 1950)202(4)1301-1310(2019 02)

Guanylate cyclase C reduces invasion of intestinal epithelial cells by bacterial pathogens.
Amarachintha S, Harmel-Laws E, Steinbrecher KA
Scientific reports8(1)1521(2018 01)

GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome.
Li P, Wuthrick E, Rappaport JA, Kraft C, Lin JE, Marszalowicz G, Snook AE, Zhan T, Hyslop TM, Waldman SA
Cancer research77(18)5095-5106(2017 09)

Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis.
Lin JE, Colon-Gonzalez F, Blomain E, Kim GW, Aing A, Stoecker B, Rock J, Snook AE, Zhan T, Hyslop TM, Tomczak M, Blumberg RS, Waldman SA
Cancer research76(2)339-46(2016 Jan)

Effect of guanylate cyclase-C activity on energy and glucose homeostasis.
Begg DP, Steinbrecher KA, Mul JD, Chambers AP, Kohli R, Haller A, Cohen MB, Woods SC, Seeley RJ
Diabetes63(11)3798-804(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Gucy2c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gucy2c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16732	NM_001127318.1 Latest version!	Mus musculus guanylate cyclase 2c (Gucy2c), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
OMu16749	NM_145067.3 Latest version!	Mus musculus guanylate cyclase 2c (Gucy2c), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gucy2c ( NM_001127318.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001120790.1 Mus musculus guanylate cyclase 2c (Gucy2c), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu16732
Clone ID Related Accession (Same CDS sequence)	NM_001127318.1
Accession Version	NM_001127318.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3219bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Mus musculus(house mouse)
Product	heat-stable enterotoxin receptor isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK136496.1 and CF353627.1. Transcript Variant: This variant (1) represents the longer transcript and and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK136496.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGTCAC TGCTGGGCTT GGCTGTGCGG TTACTGCTCT TCCAGCCCGC GCTGATGGTG 
TTCTGGGCCT CTCAGGTGAG GCAGAACTGC CGCAATGGCA GCTACGAGAT CAGCGTCCTG 
ATGATGGACA ACTCAGCCTA CAAAGAACCT ATGCAAAACC TGAGGGAGGC TGTGGAGGAA 
GGACTGGACA TAGTGCGAAA GCGCCTGCGT GAAGCCGACC TAAATGTGAC TGTGAACGCG 
ACTTTCATCT ACTCCGACGG TCTGATTCAT AAGTCAGGTG ACTGCCGGAG CAGCACCTGT 
GAAGGCCTTG ACCTACTCAG GGAGATTACA AGAGATCATA AGATGGGCTG CGCCCTCATG 
GGGCCCTCGT GCACGTATTC CACCTTCCAG ATGTACCTCG ACACAGAGTT GAACTATCCC 
ATGATTTCCG CTGGAAGTTA TGGATTGTCC TGTGACTATA AGGAAACCCT AACCAGGATC 
CTGCCTCCAG CCAGGAAGCT GATGTACTTC TTGGTCGATT TCTGGAAAGT CAACAATGCA 
TCTTTCAAAC CCTTTTCCTG GAACTCTTCG TATGTTTACA AGAATGGATC GGAACCTGAA 
GATTGTTTCT GGTACCTCAA TGCTCTGGAG GCTGGGGTGT CCTATTTTTC TGAGGTGCTC 
AACTTCAAGG ATGTACTGAG ACGCAGCGAA CAGTTCCAGG AAATCTTAAC AGGCCATAAC 
AGAAAGAGCA ATGTGATTGT TATGTGTGGC ACGCCAGAAA GCTTCTATGA TGTGAAAGGT 
GACCTCCAAG TGGCTGAAGA TACTGTTGTC ATCCTGGTAG ATCTGTTCAG TAACCATTAC 
TTTGAGGAGA ACACCACAGC TCCTGAGTAT ATGGACAATG TCCTCGTCCT GACGCTGCCG 
TCTGAACAGT CCACCTCAAA CACCTCTGTC GCCGAGAGGT TTTCATCGGG GAGAAGTGAC 
TTTTCTCTCG CTTACTTGGA GGGAACCTTG CTATTTGGAC ACATGCTGCA GACGTTTCTT 
GAAAATGGAG AAAATGTCAC GGGTCCCAAG TTTGCTCGTG CATTCAGGAA TCTCACTTTT 
CAAGGCTTTG CAGGACCTGT GACTCTGGAT GACAGTGGGG ACATTGACAA CATTATGTCC 
CTTCTGTATG TGTCTCTGGA TACCAGGAAA TACAAGGTTC TTATGAAGTA TGACACCCAC 
AAAAACAAAA CTATTCCGGT GGCTGAGAAC CCCAACTTCA TCTGGAAGAA CCACAAGCTC 
CCCAATGACG TTCCTGGGCT GGGCCCTCAA ATCCTGATGA TTGCCGTCTT CACGCTCACG 
GGGATCCTGG TAGTTCTGCT GCTGATTGCC CTCCTCGTGC TGAGAAAATA CAGAAGAGAT 
CATGCACTTC GACAGAAGAA ATGGTCCCAC ATTCCTTCTG AAAACATCTT TCCTCTGGAG 
ACCAACGAGA CCAACCACAT CAGCCTGAAG ATTGACGATG ACAGGAGACG AGACACAATC 
CAGAGAGTGC GACAGTGCAA ATACGACAAG AAGAAAGTGA TTCTGAAAGA CCTCAAGCAC 
AGCGACGGGA ACTTCAGTGA GAAGCAGAAG ATAGACCTGA ACAAGTTGCT GCAGTCTGAC 
TACTACAACC TGACTAAGTT CTACGGCACC GTGAAGCTGG ACACCAGGAT CTTTGGGGTG 
GTTGAGTACT GCGAGAGGGG ATCCCTCCGG GAAGTGTTAA ACGACACAAT TTCCTACCCT 
GACGGCACGT TCATGGATTG GGAGTTTAAG ATCTCTGTCT TAAATGACAT CGCTAAGGGG 
ATGTCCTACC TGCACTCCAG TAAGATTGAA GTCCACGGGC GTCTCAAATC CACCAACTGC 
GTGGTGGACA GCCGCATGGT GGTGAAGATC ACCGACTTTG GGTGCAATTC CATCCTGCCT 
CCAAAAAAAG ACCTGTGGAC GGCCCCGGAG CACCTGCGCC AGGCCACCAT CTCTCAGAAA 
GGAGACGTGT ACAGCTTCGC CATCATTGCC CAGGAGATCA TCCTCCGTAA GGAGACTTTT 
TACACGCTGA GCTGTCGGGA TCACAATGAG AAGATTTTCA GAGTGGAAAA TTCATACGGG 
AAACCTTTCC GCCCAGACCT CTTCCTGGAG ACTGCAGATG AGAAGGAGCT GGAGGTCTAT 
CTACTTGTCA AAAGCTGTTG GGAGGAGGAT CCAGAAAAGA GGCCAGATTT CAAGAAAATC 
GAGAGCACAC TGGCCAAGAT ATTTGGCCTT TTCCATGACC AGAAAAACGA GTCTTACATG 
GACACCTTGA TCCGACGTCT CCAGCTGTAC TCTCGAAACC TGGAACATCT GGTGGAGGAA 
AGGACTCAGC TGTACAAGGC GGAGAGGGAC AGGGCTGACC ACCTTAACTT CATGCTCCTC 
CCACGGCTGG TGGTAAAGTC ACTGAAGGAG AAAGGCATCG TGGAGCCAGA GCTGTACGAA 
GAAGTCACAA TCTACTTCAG TGACATTGTG GGCTTCACCA CCATCTGCAA GTATAGCACG 
CCCATGGAGG TGGTGGACAT GCTCAACGAC ATCTACAAGA GCTTTGACCA GATTGTGGAC 
CACCATGACG TCTACAAGGT AGAAACCATC GGTGACGCCT ACGTGGTGGC CAGCGGTCTG 
CCTATGAGAA ACGGCAACCG ACACGCGGTA GACATTTCCA AGATGGCCTT GGACATCCTC 
AGCTTCATAG GGACCTTTGA GTTGGAGCAT CTCCCTGGCC TCCCCGTGTG GATCCGCATT 
GGAGTTCATT CTGGGCCCTG CGCTGCTGGT GTTGTGGGGA TCAAGATGCC TCGCTATTGC 
CTGTTTGGAG ACACTGTCAA CACTGCCTCC AGGATGGAAT CCACCGGCCT CCCCTTGAGG 
ATTCACATGA GCAGCTCCAC CATAACCATC CTGAAGAGAA CGGATTGCCA GTTCCTGTAT 
GAAGTGAGGG GAGAAACCTA CTTAAAGGGA AGAGGGACAG AGACCACATA CTGGCTGACT 
GGGATGAAGG ACCAAGAATA CAACCTGCCA TCCCCACCGA CAGTGGAGAA CCAACAGCGT 
CTGCAGACTG AGTTCTCAGA CATGATCGTT AGCGCCTTAC AGAAAAGACA GGCCTCGGGC 
AAGAAGAGCC GGAGGCCCAC TCGGGTGGCC AGCTACAAGA AAGGCTTTCT GGAATACATG 
CAGCTGAACA ATTCAGACCA CGATAGCACC TATTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001120790.1
CDS	137..3355
Translation	MTSLLGLAVRLLLFQPALMVFWASQVRQNCRNGSYEISVLMMDNSAYKEPMQNLREAVEEGLDIVRKRLREADLNVTVNATFIYSDGLIHKSGDCRSSTCEGLDLLREITRDHKMGCALMGPSCTYSTFQMYLDTELNYPMISAGSYGLSCDYKETLTRILPPARKLMYFLVDFWKVNNASFKPFSWNSSYVYKNGSEPEDCFWYLNALEAGVSYFSEVLNFKDVLRRSEQFQEILTGHNRKSNVIVMCGTPESFYDVKGDLQVAEDTVVILVDLFSNHYFEENTTAPEYMDNVLVLTLPSEQSTSNTSVAERFSSGRSDFSLAYLEGTLLFGHMLQTFLENGENVTGPKFARAFRNLTFQGFAGPVTLDDSGDIDNIMSLLYVSLDTRKYKVLMKYDTHKNKTIPVAENPNFIWKNHKLPNDVPGLGPQILMIAVFTLTGILVVLLLIALLVLRKYRRDHALRQKKWSHIPSENIFPLETNETNHISLKIDDDRRRDTIQRVRQCKYDKKKVILKDLKHSDGNFSEKQKIDLNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQATISQKGDVYSFAIIAQEIILRKETFYTLSCRDHNEKIFRVENSYGKPFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFIGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTITILKRTDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNLPSPPTVENQQRLQTEFSDMIVSALQKRQASGKKSRRPTRVASYKKGFLEYMQLNNSDHDSTYF

Target ORF information:

RefSeq Version	NM_001127318.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus guanylate cyclase 2c (Gucy2c), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001127318.1

ORF Insert Sequence:

ATGACGTCAC TGCTGGGCTT GGCTGTGCGG TTACTGCTCT TCCAGCCCGC GCTGATGGTG 
TTCTGGGCCT CTCAGGTGAG GCAGAACTGC CGCAATGGCA GCTACGAGAT CAGCGTCCTG 
ATGATGGACA ACTCAGCCTA CAAAGAACCT ATGCAAAACC TGAGGGAGGC TGTGGAGGAA 
GGACTGGACA TAGTGCGAAA GCGCCTGCGT GAAGCCGACC TAAATGTGAC TGTGAACGCG 
ACTTTCATCT ACTCCGACGG TCTGATTCAT AAGTCAGGTG ACTGCCGGAG CAGCACCTGT 
GAAGGCCTTG ACCTACTCAG GGAGATTACA AGAGATCATA AGATGGGCTG CGCCCTCATG 
GGGCCCTCGT GCACGTATTC CACCTTCCAG ATGTACCTCG ACACAGAGTT GAACTATCCC 
ATGATTTCCG CTGGAAGTTA TGGATTGTCC TGTGACTATA AGGAAACCCT AACCAGGATC 
CTGCCTCCAG CCAGGAAGCT GATGTACTTC TTGGTCGATT TCTGGAAAGT CAACAATGCA 
TCTTTCAAAC CCTTTTCCTG GAACTCTTCG TATGTTTACA AGAATGGATC GGAACCTGAA 
GATTGTTTCT GGTACCTCAA TGCTCTGGAG GCTGGGGTGT CCTATTTTTC TGAGGTGCTC 
AACTTCAAGG ATGTACTGAG ACGCAGCGAA CAGTTCCAGG AAATCTTAAC AGGCCATAAC 
AGAAAGAGCA ATGTGATTGT TATGTGTGGC ACGCCAGAAA GCTTCTATGA TGTGAAAGGT 
GACCTCCAAG TGGCTGAAGA TACTGTTGTC ATCCTGGTAG ATCTGTTCAG TAACCATTAC 
TTTGAGGAGA ACACCACAGC TCCTGAGTAT ATGGACAATG TCCTCGTCCT GACGCTGCCG 
TCTGAACAGT CCACCTCAAA CACCTCTGTC GCCGAGAGGT TTTCATCGGG GAGAAGTGAC 
TTTTCTCTCG CTTACTTGGA GGGAACCTTG CTATTTGGAC ACATGCTGCA GACGTTTCTT 
GAAAATGGAG AAAATGTCAC GGGTCCCAAG TTTGCTCGTG CATTCAGGAA TCTCACTTTT 
CAAGGCTTTG CAGGACCTGT GACTCTGGAT GACAGTGGGG ACATTGACAA CATTATGTCC 
CTTCTGTATG TGTCTCTGGA TACCAGGAAA TACAAGGTTC TTATGAAGTA TGACACCCAC 
AAAAACAAAA CTATTCCGGT GGCTGAGAAC CCCAACTTCA TCTGGAAGAA CCACAAGCTC 
CCCAATGACG TTCCTGGGCT GGGCCCTCAA ATCCTGATGA TTGCCGTCTT CACGCTCACG 
GGGATCCTGG TAGTTCTGCT GCTGATTGCC CTCCTCGTGC TGAGAAAATA CAGAAGAGAT 
CATGCACTTC GACAGAAGAA ATGGTCCCAC ATTCCTTCTG AAAACATCTT TCCTCTGGAG 
ACCAACGAGA CCAACCACAT CAGCCTGAAG ATTGACGATG ACAGGAGACG AGACACAATC 
CAGAGAGTGC GACAGTGCAA ATACGACAAG AAGAAAGTGA TTCTGAAAGA CCTCAAGCAC 
AGCGACGGGA ACTTCAGTGA GAAGCAGAAG ATAGACCTGA ACAAGTTGCT GCAGTCTGAC 
TACTACAACC TGACTAAGTT CTACGGCACC GTGAAGCTGG ACACCAGGAT CTTTGGGGTG 
GTTGAGTACT GCGAGAGGGG ATCCCTCCGG GAAGTGTTAA ACGACACAAT TTCCTACCCT 
GACGGCACGT TCATGGATTG GGAGTTTAAG ATCTCTGTCT TAAATGACAT CGCTAAGGGG 
ATGTCCTACC TGCACTCCAG TAAGATTGAA GTCCACGGGC GTCTCAAATC CACCAACTGC 
GTGGTGGACA GCCGCATGGT GGTGAAGATC ACCGACTTTG GGTGCAATTC CATCCTGCCT 
CCAAAAAAAG ACCTGTGGAC GGCCCCGGAG CACCTGCGCC AGGCCACCAT CTCTCAGAAA 
GGAGACGTGT ACAGCTTCGC CATCATTGCC CAGGAGATCA TCCTCCGTAA GGAGACTTTT 
TACACGCTGA GCTGTCGGGA TCACAATGAG AAGATTTTCA GAGTGGAAAA TTCATACGGG 
AAACCTTTCC GCCCAGACCT CTTCCTGGAG ACTGCAGATG AGAAGGAGCT GGAGGTCTAT 
CTACTTGTCA AAAGCTGTTG GGAGGAGGAT CCAGAAAAGA GGCCAGATTT CAAGAAAATC 
GAGAGCACAC TGGCCAAGAT ATTTGGCCTT TTCCATGACC AGAAAAACGA GTCTTACATG 
GACACCTTGA TCCGACGTCT CCAGCTGTAC TCTCGAAACC TGGAACATCT GGTGGAGGAA 
AGGACTCAGC TGTACAAGGC GGAGAGGGAC AGGGCTGACC ACCTTAACTT CATGCTCCTC 
CCACGGCTGG TGGTAAAGTC ACTGAAGGAG AAAGGCATCG TGGAGCCAGA GCTGTACGAA 
GAAGTCACAA TCTACTTCAG TGACATTGTG GGCTTCACCA CCATCTGCAA GTATAGCACG 
CCCATGGAGG TGGTGGACAT GCTCAACGAC ATCTACAAGA GCTTTGACCA GATTGTGGAC 
CACCATGACG TCTACAAGGT AGAAACCATC GGTGACGCCT ACGTGGTGGC CAGCGGTCTG 
CCTATGAGAA ACGGCAACCG ACACGCGGTA GACATTTCCA AGATGGCCTT GGACATCCTC 
AGCTTCATAG GGACCTTTGA GTTGGAGCAT CTCCCTGGCC TCCCCGTGTG GATCCGCATT 
GGAGTTCATT CTGGGCCCTG CGCTGCTGGT GTTGTGGGGA TCAAGATGCC TCGCTATTGC 
CTGTTTGGAG ACACTGTCAA CACTGCCTCC AGGATGGAAT CCACCGGCCT CCCCTTGAGG 
ATTCACATGA GCAGCTCCAC CATAACCATC CTGAAGAGAA CGGATTGCCA GTTCCTGTAT 
GAAGTGAGGG GAGAAACCTA CTTAAAGGGA AGAGGGACAG AGACCACATA CTGGCTGACT 
GGGATGAAGG ACCAAGAATA CAACCTGCCA TCCCCACCGA CAGTGGAGAA CCAACAGCGT 
CTGCAGACTG AGTTCTCAGA CATGATCGTT AGCGCCTTAC AGAAAAGACA GGCCTCGGGC 
AAGAAGAGCC GGAGGCCCAC TCGGGTGGCC AGCTACAAGA AAGGCTTTCT GGAATACATG 
CAGCTGAACA ATTCAGACCA CGATAGCACC TATTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gucy2c ( NM_145067.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_659504.2 Mus musculus guanylate cyclase 2c (Gucy2c), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu16749
Clone ID Related Accession (Same CDS sequence)	NM_145067.3
Accession Version	NM_145067.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3147bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Mus musculus(house mouse)
Product	heat-stable enterotoxin receptor isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK136496.1 and CF353627.1. On May 13, 2008 this sequence version replaced NM_145067.2. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC099968.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849380 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGTCAC TGCTGGGCTT GGCTGTGCGG TTACTGCTCT TCCAGCCCGC GCTGATGGTG 
TTCTGGGCCT CTCAGGTGAG GCAGAACTGC CGCAATGGCA GCTACGAGAT CAGCGTCCTG 
ATGATGGACA ACTCAGCCTA CAAAGAACCT ATGCAAAACC TGAGGGAGGC TGTGGAGGAA 
GGACTGGACA TAGTGCGAAA GCGCCTGCGT GAAGCCGACC TAAATGTGAC TGTGAACGCG 
ACTTTCATCT ACTCCGACGG TCTGATTCAT AAGTCAGGTG ACTGCCGGAG CAGCACCTGT 
GAAGGCCTTG ACCTACTCAG GGAGATTACA AGAGATCATA AGATGGGCTG CGCCCTCATG 
GGGCCCTCGT GCACGTATTC CACCTTCCAG ATGTACCTCG ACACAGAGTT GAACTATCCC 
ATGATTTCCG CTGGAAGTTA TGGATTGTCC TGTGACTATA AGGAAACCCT AACCAGGATC 
CTGCCTCCAG CCAGGAAGCT GATGTACTTC TTGGTCGATT TCTGGAAAGT CAACAATGCA 
TCTTTCAAAC CCTTTTCCTG GAACTCTTCG TATGTTTACA AGAATGGATC GGAACCTGAA 
GATTGTTTCT GGTACCTCAA TGCTCTGGAG GCTGGGGTGT CCTATTTTTC TGAGGTGCTC 
AACTTCAAGG ATGTACTGAG ACGCAGCGAA CAGTTCCAGG AAATCTTAAC AGGCCATAAC 
AGAAAGAGCA ATGTGATTGT TATGTGTGGC ACGCCAGAAA GCTTCTATGA TGTGAAAGGT 
GACCTCCAAG TGGCTGAAGA TACTGTTGTC ATCCTGGTAG ATCTGTTCAG TAACCATTAC 
TTTGAGGAGA ACACCACAGC TCCTGAGTAT ATGGACAATG TCCTCGTCCT GACGCTGCCG 
TCTGAACAGT CCACCTCAAA CACCTCTGTC GCCGAGAGGT TTTCATCGGG GAGAAGTGAC 
TTTTCTCTCG CTTACTTGGA GGGAACCTTG CTATTTGGAC ACATGCTGCA GACGTTTCTT 
GAAAATGGAG AAAATGTCAC GGGTCCCAAG TTTGCTCGTG CATTCAGGAA TCTCACTTTT 
CAAGGCTTTG CAGGACCTGT GACTCTGGAT GACAGTGGGG ACATTGACAA CATTATGTCC 
CTTCTGTATG TGTCTCTGGA TACCAGGAAA TACAAGGTTC TTATGAAGTA TGACACCCAC 
AAAAACAAAA CTATTCCGGT GGCTGAGAAC CCCAACTTCA TCTGGAAGAA CCACAAGCTC 
CCCAATGACG TTCCTGGGCT GGGCCCTCAA ATCCTGATGA TTGCCGTCTT CACGCTCACG 
GGGATCCTGG TAGTTCTGCT GCTGATTGCC CTCCTCGTGC TGAGAAAATA CAGAAGAGAT 
CATGCACTTC GACAGAAGAA ATGGTCCCAC ATTCCTTCTG AAAACATCTT TCCTCTGGAG 
ACCAACGAGA CCAACCACAT CAGCCTGAAG ATTGACGATG ACAGGAGACG AGACACAATC 
CAGAGAGTGC GACAGTGCAA ATACGACAAG AAGTTGCTGC AGTCTGACTA CTACAACCTG 
ACTAAGTTCT ACGGCACCGT GAAGCTGGAC ACCAGGATCT TTGGGGTGGT TGAGTACTGC 
GAGAGGGGAT CCCTCCGGGA AGTGTTAAAC GACACAATTT CCTACCCTGA CGGCACGTTC 
ATGGATTGGG AGTTTAAGAT CTCTGTCTTA AATGACATCG CTAAGGGGAT GTCCTACCTG 
CACTCCAGTA AGATTGAAGT CCACGGGCGT CTCAAATCCA CCAACTGCGT GGTGGACAGC 
CGCATGGTGG TGAAGATCAC CGACTTTGGG TGCAATTCCA TCCTGCCTCC AAAAAAAGAC 
CTGTGGACGG CCCCGGAGCA CCTGCGCCAG GCCACCATCT CTCAGAAAGG AGACGTGTAC 
AGCTTCGCCA TCATTGCCCA GGAGATCATC CTCCGTAAGG AGACTTTTTA CACGCTGAGC 
TGTCGGGATC ACAATGAGAA GATTTTCAGA GTGGAAAATT CATACGGGAA ACCTTTCCGC 
CCAGACCTCT TCCTGGAGAC TGCAGATGAG AAGGAGCTGG AGGTCTATCT ACTTGTCAAA 
AGCTGTTGGG AGGAGGATCC AGAAAAGAGG CCAGATTTCA AGAAAATCGA GAGCACACTG 
GCCAAGATAT TTGGCCTTTT CCATGACCAG AAAAACGAGT CTTACATGGA CACCTTGATC 
CGACGTCTCC AGCTGTACTC TCGAAACCTG GAACATCTGG TGGAGGAAAG GACTCAGCTG 
TACAAGGCGG AGAGGGACAG GGCTGACCAC CTTAACTTCA TGCTCCTCCC ACGGCTGGTG 
GTAAAGTCAC TGAAGGAGAA AGGCATCGTG GAGCCAGAGC TGTACGAAGA AGTCACAATC 
TACTTCAGTG ACATTGTGGG CTTCACCACC ATCTGCAAGT ATAGCACGCC CATGGAGGTG 
GTGGACATGC TCAACGACAT CTACAAGAGC TTTGACCAGA TTGTGGACCA CCATGACGTC 
TACAAGGTAG AAACCATCGG TGACGCCTAC GTGGTGGCCA GCGGTCTGCC TATGAGAAAC 
GGCAACCGAC ACGCGGTAGA CATTTCCAAG ATGGCCTTGG ACATCCTCAG CTTCATAGGG 
ACCTTTGAGT TGGAGCATCT CCCTGGCCTC CCCGTGTGGA TCCGCATTGG AGTTCATTCT 
GGGCCCTGCG CTGCTGGTGT TGTGGGGATC AAGATGCCTC GCTATTGCCT GTTTGGAGAC 
ACTGTCAACA CTGCCTCCAG GATGGAATCC ACCGGCCTCC CCTTGAGGAT TCACATGAGC 
AGCTCCACCA TAACCATCCT GAAGAGAACG GATTGCCAGT TCCTGTATGA AGTGAGGGGA 
GAAACCTACT TAAAGGGAAG AGGGACAGAG ACCACATACT GGCTGACTGG GATGAAGGAC 
CAAGAATACA ACCTGCCATC CCCACCGACA GTGGAGAACC AACAGCGTCT GCAGACTGAG 
TTCTCAGACA TGATCGTTAG CGCCTTACAG AAAAGACAGG CCTCGGGCAA GAAGAGCCGG 
AGGCCCACTC GGGTGGCCAG CTACAAGAAA GGCTTTCTGG AATACATGCA GCTGAACAAT 
TCAGACCACG ATAGCACCTA TTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_659504.2
CDS	137..3283
Translation	MTSLLGLAVRLLLFQPALMVFWASQVRQNCRNGSYEISVLMMDNSAYKEPMQNLREAVEEGLDIVRKRLREADLNVTVNATFIYSDGLIHKSGDCRSSTCEGLDLLREITRDHKMGCALMGPSCTYSTFQMYLDTELNYPMISAGSYGLSCDYKETLTRILPPARKLMYFLVDFWKVNNASFKPFSWNSSYVYKNGSEPEDCFWYLNALEAGVSYFSEVLNFKDVLRRSEQFQEILTGHNRKSNVIVMCGTPESFYDVKGDLQVAEDTVVILVDLFSNHYFEENTTAPEYMDNVLVLTLPSEQSTSNTSVAERFSSGRSDFSLAYLEGTLLFGHMLQTFLENGENVTGPKFARAFRNLTFQGFAGPVTLDDSGDIDNIMSLLYVSLDTRKYKVLMKYDTHKNKTIPVAENPNFIWKNHKLPNDVPGLGPQILMIAVFTLTGILVVLLLIALLVLRKYRRDHALRQKKWSHIPSENIFPLETNETNHISLKIDDDRRRDTIQRVRQCKYDKKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQATISQKGDVYSFAIIAQEIILRKETFYTLSCRDHNEKIFRVENSYGKPFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFIGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTITILKRTDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNLPSPPTVENQQRLQTEFSDMIVSALQKRQASGKKSRRPTRVASYKKGFLEYMQLNNSDHDSTYF

Target ORF information:

RefSeq Version	NM_145067.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus guanylate cyclase 2c (Gucy2c), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145067.3

ORF Insert Sequence:

ATGACGTCAC TGCTGGGCTT GGCTGTGCGG TTACTGCTCT TCCAGCCCGC GCTGATGGTG 
TTCTGGGCCT CTCAGGTGAG GCAGAACTGC CGCAATGGCA GCTACGAGAT CAGCGTCCTG 
ATGATGGACA ACTCAGCCTA CAAAGAACCT ATGCAAAACC TGAGGGAGGC TGTGGAGGAA 
GGACTGGACA TAGTGCGAAA GCGCCTGCGT GAAGCCGACC TAAATGTGAC TGTGAACGCG 
ACTTTCATCT ACTCCGACGG TCTGATTCAT AAGTCAGGTG ACTGCCGGAG CAGCACCTGT 
GAAGGCCTTG ACCTACTCAG GGAGATTACA AGAGATCATA AGATGGGCTG CGCCCTCATG 
GGGCCCTCGT GCACGTATTC CACCTTCCAG ATGTACCTCG ACACAGAGTT GAACTATCCC 
ATGATTTCCG CTGGAAGTTA TGGATTGTCC TGTGACTATA AGGAAACCCT AACCAGGATC 
CTGCCTCCAG CCAGGAAGCT GATGTACTTC TTGGTCGATT TCTGGAAAGT CAACAATGCA 
TCTTTCAAAC CCTTTTCCTG GAACTCTTCG TATGTTTACA AGAATGGATC GGAACCTGAA 
GATTGTTTCT GGTACCTCAA TGCTCTGGAG GCTGGGGTGT CCTATTTTTC TGAGGTGCTC 
AACTTCAAGG ATGTACTGAG ACGCAGCGAA CAGTTCCAGG AAATCTTAAC AGGCCATAAC 
AGAAAGAGCA ATGTGATTGT TATGTGTGGC ACGCCAGAAA GCTTCTATGA TGTGAAAGGT 
GACCTCCAAG TGGCTGAAGA TACTGTTGTC ATCCTGGTAG ATCTGTTCAG TAACCATTAC 
TTTGAGGAGA ACACCACAGC TCCTGAGTAT ATGGACAATG TCCTCGTCCT GACGCTGCCG 
TCTGAACAGT CCACCTCAAA CACCTCTGTC GCCGAGAGGT TTTCATCGGG GAGAAGTGAC 
TTTTCTCTCG CTTACTTGGA GGGAACCTTG CTATTTGGAC ACATGCTGCA GACGTTTCTT 
GAAAATGGAG AAAATGTCAC GGGTCCCAAG TTTGCTCGTG CATTCAGGAA TCTCACTTTT 
CAAGGCTTTG CAGGACCTGT GACTCTGGAT GACAGTGGGG ACATTGACAA CATTATGTCC 
CTTCTGTATG TGTCTCTGGA TACCAGGAAA TACAAGGTTC TTATGAAGTA TGACACCCAC 
AAAAACAAAA CTATTCCGGT GGCTGAGAAC CCCAACTTCA TCTGGAAGAA CCACAAGCTC 
CCCAATGACG TTCCTGGGCT GGGCCCTCAA ATCCTGATGA TTGCCGTCTT CACGCTCACG 
GGGATCCTGG TAGTTCTGCT GCTGATTGCC CTCCTCGTGC TGAGAAAATA CAGAAGAGAT 
CATGCACTTC GACAGAAGAA ATGGTCCCAC ATTCCTTCTG AAAACATCTT TCCTCTGGAG 
ACCAACGAGA CCAACCACAT CAGCCTGAAG ATTGACGATG ACAGGAGACG AGACACAATC 
CAGAGAGTGC GACAGTGCAA ATACGACAAG AAGTTGCTGC AGTCTGACTA CTACAACCTG 
ACTAAGTTCT ACGGCACCGT GAAGCTGGAC ACCAGGATCT TTGGGGTGGT TGAGTACTGC 
GAGAGGGGAT CCCTCCGGGA AGTGTTAAAC GACACAATTT CCTACCCTGA CGGCACGTTC 
ATGGATTGGG AGTTTAAGAT CTCTGTCTTA AATGACATCG CTAAGGGGAT GTCCTACCTG 
CACTCCAGTA AGATTGAAGT CCACGGGCGT CTCAAATCCA CCAACTGCGT GGTGGACAGC 
CGCATGGTGG TGAAGATCAC CGACTTTGGG TGCAATTCCA TCCTGCCTCC AAAAAAAGAC 
CTGTGGACGG CCCCGGAGCA CCTGCGCCAG GCCACCATCT CTCAGAAAGG AGACGTGTAC 
AGCTTCGCCA TCATTGCCCA GGAGATCATC CTCCGTAAGG AGACTTTTTA CACGCTGAGC 
TGTCGGGATC ACAATGAGAA GATTTTCAGA GTGGAAAATT CATACGGGAA ACCTTTCCGC 
CCAGACCTCT TCCTGGAGAC TGCAGATGAG AAGGAGCTGG AGGTCTATCT ACTTGTCAAA 
AGCTGTTGGG AGGAGGATCC AGAAAAGAGG CCAGATTTCA AGAAAATCGA GAGCACACTG 
GCCAAGATAT TTGGCCTTTT CCATGACCAG AAAAACGAGT CTTACATGGA CACCTTGATC 
CGACGTCTCC AGCTGTACTC TCGAAACCTG GAACATCTGG TGGAGGAAAG GACTCAGCTG 
TACAAGGCGG AGAGGGACAG GGCTGACCAC CTTAACTTCA TGCTCCTCCC ACGGCTGGTG 
GTAAAGTCAC TGAAGGAGAA AGGCATCGTG GAGCCAGAGC TGTACGAAGA AGTCACAATC 
TACTTCAGTG ACATTGTGGG CTTCACCACC ATCTGCAAGT ATAGCACGCC CATGGAGGTG 
GTGGACATGC TCAACGACAT CTACAAGAGC TTTGACCAGA TTGTGGACCA CCATGACGTC 
TACAAGGTAG AAACCATCGG TGACGCCTAC GTGGTGGCCA GCGGTCTGCC TATGAGAAAC 
GGCAACCGAC ACGCGGTAGA CATTTCCAAG ATGGCCTTGG ACATCCTCAG CTTCATAGGG 
ACCTTTGAGT TGGAGCATCT CCCTGGCCTC CCCGTGTGGA TCCGCATTGG AGTTCATTCT 
GGGCCCTGCG CTGCTGGTGT TGTGGGGATC AAGATGCCTC GCTATTGCCT GTTTGGAGAC 
ACTGTCAACA CTGCCTCCAG GATGGAATCC ACCGGCCTCC CCTTGAGGAT TCACATGAGC 
AGCTCCACCA TAACCATCCT GAAGAGAACG GATTGCCAGT TCCTGTATGA AGTGAGGGGA 
GAAACCTACT TAAAGGGAAG AGGGACAGAG ACCACATACT GGCTGACTGG GATGAAGGAC 
CAAGAATACA ACCTGCCATC CCCACCGACA GTGGAGAACC AACAGCGTCT GCAGACTGAG 
TTCTCAGACA TGATCGTTAG CGCCTTACAG AAAAGACAGG CCTCGGGCAA GAAGAGCCGG 
AGGCCCACTC GGGTGGCCAG CTACAAGAAA GGCTTTCTGG AATACATGCA GCTGAACAAT 
TCAGACCACG ATAGCACCTA TTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TCR Retrogenic Mice as a Model To Map Self-Tolerance Mechanisms to the Cancer Mucosa Antigen GUCY2C.
Journal of immunology (Baltimore, Md. : 1950)202(4)1301-1310(2019 02)
Abraham TS,Flickinger JC Jr,Waldman SA,Snook AE

Guanylate cyclase C reduces invasion of intestinal epithelial cells by bacterial pathogens.
Scientific reports8(1)1521(2018 01)
Amarachintha S,Harmel-Laws E,Steinbrecher KA

GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome.
Cancer research77(18)5095-5106(2017 09)
Li P,Wuthrick E,Rappaport JA,Kraft C,Lin JE,Marszalowicz G,Snook AE,Zhan T,Hyslop TM,Waldman SA

Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis.
Cancer research76(2)339-46(2016 Jan)
Lin JE,Colon-Gonzalez F,Blomain E,Kim GW,Aing A,Stoecker B,Rock J,Snook AE,Zhan T,Hyslop TM,Tomczak M,Blumberg RS,Waldman SA

Effect of guanylate cyclase-C activity on energy and glucose homeostasis.
Diabetes63(11)3798-804(2014 Nov)
Begg DP,Steinbrecher KA,Mul JD,Chambers AP,Kohli R,Haller A,Cohen MB,Woods SC,Seeley RJ

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Gucy2c cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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