GUCY2C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GUCY2C
Entrez Gene ID	2984
Full Name	guanylate cyclase 2C
Synonyms	DIAR6,GC-C,GUC2C,MECIL,MUCIL,STAR
General protein information	Preferred Names guanylate cyclase 2C Names heat-stable enterotoxin receptor STA receptor guanylyl cyclase C intestinal guanylate cyclase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p12.3
Summary	This gene encodes a transmembrane protein that functions as a receptor for endogenous peptides guanylin and uroguanylin, and the heat-stable E. coli enterotoxin. The encoded protein activates the cystic fibrosis transmembrane conductance regulator. Mutations in this gene are associated with familial diarrhea (autosomal dominant) and meconium ileus (autosomal recessive). [provided by RefSeq, Nov 2016].
Disorder MIM:	601330
Disorder Html:	Diarrhea 6, 614616 (3); Meconium ileus, 614665 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011520631.2	XP_011518933.1	heat-stable enterotoxin receptor isoform X1
NM_004963.3	NP_004954.2	heat-stable enterotoxin receptor precursor
NM_004963.4	NP_004954.2	heat-stable enterotoxin receptor precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GUCY2C	XP_528746.2
Macaca mulatta (Rhesus monkey)	GUCY2C	XP_001089601.1
Danio rerio (zebrafish)	LOC568219	XP_696628.4
Homo sapiens (human)	GUCY2C	NP_004954.2
Bos taurus (cattle)	GUCY2C	NP_776972.1
Mus musculus (house mouse)	Gucy2c	NP_001120790.1
Rattus norvegicus (Norway rat)	Gucy2c	NP_037302.1
Xenopus tropicalis (tropical clawed frog)	gucy2c	XP_002934756.1
Canis lupus familiaris (dog)	GUCY2C	XP_543798.3
Danio rerio (zebrafish)	LOC572052	XP_700803.6
Gallus gallus (chicken)	GUCY2C	XP_416207.3

Gene Ontology
Bibliography

Related articles in PubMed

Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C-linked familial diarrhea.
Tronstad RR, Polushina T, Brattbakk HR, Stansberg C, von Volkmann HL, Hanevik K, Ellinghaus E, Jørgensen SF, Ersland KM, Pham KD, Gilja OH, Hovdenak N, Hausken T, Vatn MH, Franke A, Knappskog PM, Le Hellard S, Karlsen TH, Fiskerstrand T
Scandinavian journal of gastroenterology53(10-11)1264-1273(2018 Oct - Nov)

Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases.
Magee MS, Abraham TS, Baybutt TR, Flickinger JC Jr, Ridge NA, Marszalowicz GP, Prajapati P, Hersperger AR, Waldman SA, Snook AE
Cancer immunology research6(5)509-516(2018 05)

Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease.
Tronstad RR, Kummen M, Holm K, von Volkmann HL, Anmarkrud JA, Høivik ML, Moum B, Gilja OH, Hausken T, Baines J, Karlsen TH, Fiskerstrand T, Hov JR
Inflammatory bowel diseases23(10)1752-1761(2017 10)

Consistent expression of guanylyl cyclase-C in primary and metastatic gastrointestinal cancers.
Danaee H, Kalebic T, Wyant T, Fassan M, Mescoli C, Gao F, Trepicchio WL, Rugge M
PloS one12(12)e0189953(2017)

Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation.
von Volkmann HL, Brønstad I, Gilja OH, R Tronstad R, Sangnes DA, Nortvedt R, Hausken T, Dimcevski G, Fiskerstrand T, Nylund K
PloS one12(9)e0185496(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GUCY2C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GUCY2C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu58164	XM_011520631.2 Latest version!	Homo sapiens guanylate cyclase 2C (GUCY2C), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
OHu14859	NM_004963.4 Latest version!	Homo sapiens guanylate cyclase 2C (GUCY2C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
View Old Accession Versions >>
OHu14859	NM_004963.3	Homo sapiens guanylate cyclase 2C (GUCY2C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GUCY2C ( XM_011520631.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011518933.1 Homo sapiens guanylate cyclase 2C (GUCY2C), transcript variant X1, mRNA.

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CloneID	OHu58164
Clone ID Related Accession (Same CDS sequence)	XM_011520631.2
Accession Version	XM_011520631.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2976bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	heat-stable enterotoxin receptor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011520631.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTATTCGG ATGGTCTGAT TCATAACTCA GGCGACTGCC GGAGTAGCAC CTGTGAAGGC 
CTCGACCTAC TCAGGAAAAT TTCAAATGCA CAACGGATGG GCTGTGTCCT CATAGGGCCC 
TCATGTACAT ACTCCACCTT CCAGATGTAC CTTGACACAG AATTGAGCTA CCCCATGATC 
TCAGCTGGAA GTTTTGGATT GTCATGTGAC TATAAAGAAA CCTTAACCAG GCTGATGTCT 
CCAGCTAGAA AGTTGATGTA CTTCTTGGTT AACTTTTGGA AAACCAACGA TCTGCCCTTC 
AAAACTTATT CCTGGAGCAC TTCGTATGTT TACAAGAATG GTACAGAAAC TGAGGACTGT 
TTCTGGTACC TTAATGCTCT GGAGGCTAGC GTTTCCTATT TCTCCCACGA ACTCGGCTTT 
AAGGTGGTGT TAAGACAAGA TAAGGAGTTT CAGGATATCT TAATGGACCA CAACAGGAAA 
AGCAATGTGA TTATTATGTG TGGTGGTCCA GAGTTCCTCT ACAAGCTGAA GGGTGACCGA 
GCAGTGGCTG AAGACATTGT CATTATTCTA GTGGATCTTT TCAATGACCA GTACTTTGAG 
GACAATGTCA CAGCCCCTGA CTATATGAAA AATGTCCTTG TTCTGACGCT GTCTCCTGGG 
AATTCCCTTC TAAATAGCTC TTTCTCCAGG AATCTATCAC CAACAAAACG AGACTTTGCT 
CTTGCCTATT TGAATGGAAT CCTGCTCTTT GGACATATGC TGAAGATATT TCTTGAAAAT 
GGAGAAAATA TTACCACCCC CAAATTTGCT CATGCTTTCA GGAATCTCAC TTTTGAAGGG 
TATGACGGTC CAGTGACCTT GGATGACTGG GGGGATGTTG ACAGTACCAT GGTGCTTCTG 
TATACCTCTG TGGACACCAA GAAATACAAG GTTCTTTTGA CCTATGATAC CCACGTAAAT 
AAGACCTATC CTGTGGATAT GAGCCCCACA TTCACTTGGA AGAACTCTAA ACTTCCTAAT 
GATATTACAG GCCGGGGCCC TCAGATCCTG ATGATTGCAG TCTTCACCCT CACTGGAGCT 
GTGGTGCTGC TCCTGCTCGT CGCTCTCCTG ATGCTCAGAA AATATAGAAA AGATTATGAA 
CTTCGTCAGA AAAAATGGTC CCACATTCCT CCTGAAAATA TCTTTCCTCT GGAGACCAAT 
GAGACCAATC ATGTTAGCCT CAAGATCGAT GATGACAAAA GACGAGATAC AATCCAGAGA 
CTACGACAGT GCAAATACGA CAAAAAGCGA GTGATTCTCA AAGATCTCAA GCACAATGAT 
GGTAATTTCA CTGAAAAACA GAAGATAGAA TTGAACAAGT TGCTTCAGAT TGACTATTAC 
AACCTGACCA AGTTCTACGG CACAGTGAAA CTTGATACCA TGATCTTCGG GGTGATAGAA 
TACTGTGAGA GAGGATCCCT CCGGGAAGTT TTAAATGACA CAATTTCCTA CCCTGATGGC 
ACATTCATGG ATTGGGAGTT TAAGATCTCT GTCTTGTATG ACATTGCTAA GGGAATGTCA 
TATCTGCACT CCAGTAAGAC AGAAGTCCAT GGTCGTCTGA AATCTACCAA CTGCGTAGTG 
GACAGTAGAA TGGTGGTGAA GATCACTGAT TTTGGCTGCA ATTCCATTTT ACCTCCAAAA 
AAGGACCTGT GGACAGCTCC AGAGCACCTC CGCCAAGCCA ACATCTCTCA GAAAGGAGAT 
GTGTACAGCT ATGGGATCAT CGCACAGGAG ATCATCCTGC GGAAAGAAAC CTTCTACACT 
TTGAGCTGTC GGGACCGGAA TGAGAAGATT TTCAGAGTGG AAAATTCCAA TGGAATGAAA 
CCCTTCCGCC CAGATTTATT CTTGGAAACA GCAGAGGAAA AAGAGCTAGA AGTGTACCTA 
CTTGTAAAAA ACTGTTGGGA GGAAGATCCA GAAAAGAGAC CAGATTTCAA AAAAATTGAG 
ACTACACTTG CCAAGATATT TGGACTTTTT CATGACCAAA AAAATGAAAG CTATATGGAT 
ACCTTGATCC GACGTCTACA GCTATATTCT CGAAACCTGG AACATCTGGT AGAGGAAAGG 
ACACAGCTGT ACAAGGCAGA GAGGGACAGG GCTGACAGAC TTAACTTTAT GTTGCTTCCA 
AGGCTAGTGG TAAAGTCTCT GAAGGAGAAA GGCTTTGTGG AGCCGGAACT ATATGAGGAA 
GTTACAATCT ACTTCAGTGA CATTGTAGGT TTCACTACTA TCTGCAAATA CAGCACCCCC 
ATGGAAGTGG TGGACATGCT TAATGACATC TATAAGAGTT TTGACCACAT TGTTGATCAT 
CATGATGTCT ACAAGGTGGA AACCATCGGT GATGCGTACA TGGTGGCTAG TGGTTTGCCT 
AAGAGAAATG GCAATCGGCA TGCAATAGAC ATTGCCAAGA TGGCCTTGGA AATCCTCAGC 
TTCATGGGGA CCTTTGAGCT GGAGCATCTT CCTGGCCTCC CAATATGGAT TCGCATTGGA 
GTTCACTCTG GTCCCTGTGC TGCTGGAGTT GTGGGAATCA AGATGCCTCG TTATTGTCTA 
TTTGGAGATA CGGTCAACAC AGCCTCTAGG ATGGAATCCA CTGGCCTCCC TTTGAGAATT 
CACGTGAGTG GCTCCACCAT AGCCATCCTG AAGAGAACTG AGTGCCAGTT CCTTTATGAA 
GTGAGAGGAG AAACATACTT AAAGGGAAGA GGAAATGAGA CTACCTACTG GCTGACTGGG 
ATGAAGGACC AGAAATTCAA CCTGCCAACC CCTCCTACTG TGGAGAATCA ACAGCGTTTG 
CAAGCAGAAT TTTCAGACAT GATTGCCAAC TCTTTACAGA AAAGACAGGC AGCAGGGATA 
AGAAGCCAAA AACCCAGACG GGTAGCCAGC TATAAAAAAG GCACTCTGGA ATACTTGCAG 
CTGAATACCA CAGACAAGGA GAGCACCTAT TTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011518933.1
CDS	282..3257
Translation	MYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLIGPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDLPFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTFEGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPNDITGRGPQILMIAVFTLTGAVVLLLLVALLMLRKYRKDYELRQKKWSHIPPENIFPLETNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQRLQAEFSDMIANSLQKRQAAGIRSQKPRRVASYKKGTLEYLQLNTTDKESTYF

Target ORF information:

RefSeq Version	XM_011520631.2
Organism	Homo sapiens(human)
Definition	Homo sapiens guanylate cyclase 2C (GUCY2C), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520631.2

ORF Insert Sequence:

ATGTATTCGG ATGGTCTGAT TCATAACTCA GGCGACTGCC GGAGTAGCAC CTGTGAAGGC 
CTCGACCTAC TCAGGAAAAT TTCAAATGCA CAACGGATGG GCTGTGTCCT CATAGGGCCC 
TCATGTACAT ACTCCACCTT CCAGATGTAC CTTGACACAG AATTGAGCTA CCCCATGATC 
TCAGCTGGAA GTTTTGGATT GTCATGTGAC TATAAAGAAA CCTTAACCAG GCTGATGTCT 
CCAGCTAGAA AGTTGATGTA CTTCTTGGTT AACTTTTGGA AAACCAACGA TCTGCCCTTC 
AAAACTTATT CCTGGAGCAC TTCGTATGTT TACAAGAATG GTACAGAAAC TGAGGACTGT 
TTCTGGTACC TTAATGCTCT GGAGGCTAGC GTTTCCTATT TCTCCCACGA ACTCGGCTTT 
AAGGTGGTGT TAAGACAAGA TAAGGAGTTT CAGGATATCT TAATGGACCA CAACAGGAAA 
AGCAATGTGA TTATTATGTG TGGTGGTCCA GAGTTCCTCT ACAAGCTGAA GGGTGACCGA 
GCAGTGGCTG AAGACATTGT CATTATTCTA GTGGATCTTT TCAATGACCA GTACTTTGAG 
GACAATGTCA CAGCCCCTGA CTATATGAAA AATGTCCTTG TTCTGACGCT GTCTCCTGGG 
AATTCCCTTC TAAATAGCTC TTTCTCCAGG AATCTATCAC CAACAAAACG AGACTTTGCT 
CTTGCCTATT TGAATGGAAT CCTGCTCTTT GGACATATGC TGAAGATATT TCTTGAAAAT 
GGAGAAAATA TTACCACCCC CAAATTTGCT CATGCTTTCA GGAATCTCAC TTTTGAAGGG 
TATGACGGTC CAGTGACCTT GGATGACTGG GGGGATGTTG ACAGTACCAT GGTGCTTCTG 
TATACCTCTG TGGACACCAA GAAATACAAG GTTCTTTTGA CCTATGATAC CCACGTAAAT 
AAGACCTATC CTGTGGATAT GAGCCCCACA TTCACTTGGA AGAACTCTAA ACTTCCTAAT 
GATATTACAG GCCGGGGCCC TCAGATCCTG ATGATTGCAG TCTTCACCCT CACTGGAGCT 
GTGGTGCTGC TCCTGCTCGT CGCTCTCCTG ATGCTCAGAA AATATAGAAA AGATTATGAA 
CTTCGTCAGA AAAAATGGTC CCACATTCCT CCTGAAAATA TCTTTCCTCT GGAGACCAAT 
GAGACCAATC ATGTTAGCCT CAAGATCGAT GATGACAAAA GACGAGATAC AATCCAGAGA 
CTACGACAGT GCAAATACGA CAAAAAGCGA GTGATTCTCA AAGATCTCAA GCACAATGAT 
GGTAATTTCA CTGAAAAACA GAAGATAGAA TTGAACAAGT TGCTTCAGAT TGACTATTAC 
AACCTGACCA AGTTCTACGG CACAGTGAAA CTTGATACCA TGATCTTCGG GGTGATAGAA 
TACTGTGAGA GAGGATCCCT CCGGGAAGTT TTAAATGACA CAATTTCCTA CCCTGATGGC 
ACATTCATGG ATTGGGAGTT TAAGATCTCT GTCTTGTATG ACATTGCTAA GGGAATGTCA 
TATCTGCACT CCAGTAAGAC AGAAGTCCAT GGTCGTCTGA AATCTACCAA CTGCGTAGTG 
GACAGTAGAA TGGTGGTGAA GATCACTGAT TTTGGCTGCA ATTCCATTTT ACCTCCAAAA 
AAGGACCTGT GGACAGCTCC AGAGCACCTC CGCCAAGCCA ACATCTCTCA GAAAGGAGAT 
GTGTACAGCT ATGGGATCAT CGCACAGGAG ATCATCCTGC GGAAAGAAAC CTTCTACACT 
TTGAGCTGTC GGGACCGGAA TGAGAAGATT TTCAGAGTGG AAAATTCCAA TGGAATGAAA 
CCCTTCCGCC CAGATTTATT CTTGGAAACA GCAGAGGAAA AAGAGCTAGA AGTGTACCTA 
CTTGTAAAAA ACTGTTGGGA GGAAGATCCA GAAAAGAGAC CAGATTTCAA AAAAATTGAG 
ACTACACTTG CCAAGATATT TGGACTTTTT CATGACCAAA AAAATGAAAG CTATATGGAT 
ACCTTGATCC GACGTCTACA GCTATATTCT CGAAACCTGG AACATCTGGT AGAGGAAAGG 
ACACAGCTGT ACAAGGCAGA GAGGGACAGG GCTGACAGAC TTAACTTTAT GTTGCTTCCA 
AGGCTAGTGG TAAAGTCTCT GAAGGAGAAA GGCTTTGTGG AGCCGGAACT ATATGAGGAA 
GTTACAATCT ACTTCAGTGA CATTGTAGGT TTCACTACTA TCTGCAAATA CAGCACCCCC 
ATGGAAGTGG TGGACATGCT TAATGACATC TATAAGAGTT TTGACCACAT TGTTGATCAT 
CATGATGTCT ACAAGGTGGA AACCATCGGT GATGCGTACA TGGTGGCTAG TGGTTTGCCT 
AAGAGAAATG GCAATCGGCA TGCAATAGAC ATTGCCAAGA TGGCCTTGGA AATCCTCAGC 
TTCATGGGGA CCTTTGAGCT GGAGCATCTT CCTGGCCTCC CAATATGGAT TCGCATTGGA 
GTTCACTCTG GTCCCTGTGC TGCTGGAGTT GTGGGAATCA AGATGCCTCG TTATTGTCTA 
TTTGGAGATA CGGTCAACAC AGCCTCTAGG ATGGAATCCA CTGGCCTCCC TTTGAGAATT 
CACGTGAGTG GCTCCACCAT AGCCATCCTG AAGAGAACTG AGTGCCAGTT CCTTTATGAA 
GTGAGAGGAG AAACATACTT AAAGGGAAGA GGAAATGAGA CTACCTACTG GCTGACTGGG 
ATGAAGGACC AGAAATTCAA CCTGCCAACC CCTCCTACTG TGGAGAATCA ACAGCGTTTG 
CAAGCAGAAT TTTCAGACAT GATTGCCAAC TCTTTACAGA AAAGACAGGC AGCAGGGATA 
AGAAGCCAAA AACCCAGACG GGTAGCCAGC TATAAAAAAG GCACTCTGGA ATACTTGCAG 
CTGAATACCA CAGACAAGGA GAGCACCTAT TTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GUCY2C ( NM_004963.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004954.2 Homo sapiens guanylate cyclase 2C (GUCY2C), mRNA.

Price & Availability↑

CloneID	OHu14859
Clone ID Related Accession (Same CDS sequence)	NM_004963.3 , NM_004963.4
Accession Version	NM_004963.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3222bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1508688000000
Organism	Homo sapiens(human)
Product	heat-stable enterotoxin receptor precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AW848739.1, M73489.1, AC007545.13 and S57551.1. This sequence is a reference standard in the RefSeqGene project. On Jan 28, 2009 this sequence version replaced NM_004963.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M73489.1, S57551.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGACGT TGCTGTTGGA CTTGGCTTTG TGGTCACTGC TCTTCCAGCC CGGGTGGCTG 
TCCTTTAGTT CCCAGGTGAG TCAGAACTGC CACAATGGCA GCTATGAAAT CAGCGTCCTG 
ATGATGGGCA ACTCAGCCTT TGCAGAGCCC CTGAAAAACT TGGAAGATGC GGTGAATGAG 
GGGCTGGAAA TAGTGAGAGG ACGTCTGCAA AATGCTGGCC TAAATGTGAC TGTGAACGCT 
ACTTTCATGT ATTCGGATGG TCTGATTCAT AACTCAGGCG ACTGCCGGAG TAGCACCTGT 
GAAGGCCTCG ACCTACTCAG GAAAATTTCA AATGCACAAC GGATGGGCTG TGTCCTCATA 
GGGCCCTCAT GTACATACTC CACCTTCCAG ATGTACCTTG ACACAGAATT GAGCTACCCC 
ATGATCTCAG CTGGAAGTTT TGGATTGTCA TGTGACTATA AAGAAACCTT AACCAGGCTG 
ATGTCTCCAG CTAGAAAGTT GATGTACTTC TTGGTTAACT TTTGGAAAAC CAACGATCTG 
CCCTTCAAAA CTTATTCCTG GAGCACTTCG TATGTTTACA AGAATGGTAC AGAAACTGAG 
GACTGTTTCT GGTACCTTAA TGCTCTGGAG GCTAGCGTTT CCTATTTCTC CCACGAACTC 
GGCTTTAAGG TGGTGTTAAG ACAAGATAAG GAGTTTCAGG ATATCTTAAT GGACCACAAC 
AGGAAAAGCA ATGTGATTAT TATGTGTGGT GGTCCAGAGT TCCTCTACAA GCTGAAGGGT 
GACCGAGCAG TGGCTGAAGA CATTGTCATT ATTCTAGTGG ATCTTTTCAA TGACCAGTAC 
TTTGAGGACA ATGTCACAGC CCCTGACTAT ATGAAAAATG TCCTTGTTCT GACGCTGTCT 
CCTGGGAATT CCCTTCTAAA TAGCTCTTTC TCCAGGAATC TATCACCAAC AAAACGAGAC 
TTTGCTCTTG CCTATTTGAA TGGAATCCTG CTCTTTGGAC ATATGCTGAA GATATTTCTT 
GAAAATGGAG AAAATATTAC CACCCCCAAA TTTGCTCATG CTTTCAGGAA TCTCACTTTT 
GAAGGGTATG ACGGTCCAGT GACCTTGGAT GACTGGGGGG ATGTTGACAG TACCATGGTG 
CTTCTGTATA CCTCTGTGGA CACCAAGAAA TACAAGGTTC TTTTGACCTA TGATACCCAC 
GTAAATAAGA CCTATCCTGT GGATATGAGC CCCACATTCA CTTGGAAGAA CTCTAAACTT 
CCTAATGATA TTACAGGCCG GGGCCCTCAG ATCCTGATGA TTGCAGTCTT CACCCTCACT 
GGAGCTGTGG TGCTGCTCCT GCTCGTCGCT CTCCTGATGC TCAGAAAATA TAGAAAAGAT 
TATGAACTTC GTCAGAAAAA ATGGTCCCAC ATTCCTCCTG AAAATATCTT TCCTCTGGAG 
ACCAATGAGA CCAATCATGT TAGCCTCAAG ATCGATGATG ACAAAAGACG AGATACAATC 
CAGAGACTAC GACAGTGCAA ATACGACAAA AAGCGAGTGA TTCTCAAAGA TCTCAAGCAC 
AATGATGGTA ATTTCACTGA AAAACAGAAG ATAGAATTGA ACAAGTTGCT TCAGATTGAC 
TATTACAACC TGACCAAGTT CTACGGCACA GTGAAACTTG ATACCATGAT CTTCGGGGTG 
ATAGAATACT GTGAGAGAGG ATCCCTCCGG GAAGTTTTAA ATGACACAAT TTCCTACCCT 
GATGGCACAT TCATGGATTG GGAGTTTAAG ATCTCTGTCT TGTATGACAT TGCTAAGGGA 
ATGTCATATC TGCACTCCAG TAAGACAGAA GTCCATGGTC GTCTGAAATC TACCAACTGC 
GTAGTGGACA GTAGAATGGT GGTGAAGATC ACTGATTTTG GCTGCAATTC CATTTTACCT 
CCAAAAAAGG ACCTGTGGAC AGCTCCAGAG CACCTCCGCC AAGCCAACAT CTCTCAGAAA 
GGAGATGTGT ACAGCTATGG GATCATCGCA CAGGAGATCA TCCTGCGGAA AGAAACCTTC 
TACACTTTGA GCTGTCGGGA CCGGAATGAG AAGATTTTCA GAGTGGAAAA TTCCAATGGA 
ATGAAACCCT TCCGCCCAGA TTTATTCTTG GAAACAGCAG AGGAAAAAGA GCTAGAAGTG 
TACCTACTTG TAAAAAACTG TTGGGAGGAA GATCCAGAAA AGAGACCAGA TTTCAAAAAA 
ATTGAGACTA CACTTGCCAA GATATTTGGA CTTTTTCATG ACCAAAAAAA TGAAAGCTAT 
ATGGATACCT TGATCCGACG TCTACAGCTA TATTCTCGAA ACCTGGAACA TCTGGTAGAG 
GAAAGGACAC AGCTGTACAA GGCAGAGAGG GACAGGGCTG ACAGACTTAA CTTTATGTTG 
CTTCCAAGGC TAGTGGTAAA GTCTCTGAAG GAGAAAGGCT TTGTGGAGCC GGAACTATAT 
GAGGAAGTTA CAATCTACTT CAGTGACATT GTAGGTTTCA CTACTATCTG CAAATACAGC 
ACCCCCATGG AAGTGGTGGA CATGCTTAAT GACATCTATA AGAGTTTTGA CCACATTGTT 
GATCATCATG ATGTCTACAA GGTGGAAACC ATCGGTGATG CGTACATGGT GGCTAGTGGT 
TTGCCTAAGA GAAATGGCAA TCGGCATGCA ATAGACATTG CCAAGATGGC CTTGGAAATC 
CTCAGCTTCA TGGGGACCTT TGAGCTGGAG CATCTTCCTG GCCTCCCAAT ATGGATTCGC 
ATTGGAGTTC ACTCTGGTCC CTGTGCTGCT GGAGTTGTGG GAATCAAGAT GCCTCGTTAT 
TGTCTATTTG GAGATACGGT CAACACAGCC TCTAGGATGG AATCCACTGG CCTCCCTTTG 
AGAATTCACG TGAGTGGCTC CACCATAGCC ATCCTGAAGA GAACTGAGTG CCAGTTCCTT 
TATGAAGTGA GAGGAGAAAC ATACTTAAAG GGAAGAGGAA ATGAGACTAC CTACTGGCTG 
ACTGGGATGA AGGACCAGAA ATTCAACCTG CCAACCCCTC CTACTGTGGA GAATCAACAG 
CGTTTGCAAG CAGAATTTTC AGACATGATT GCCAACTCTT TACAGAAAAG ACAGGCAGCA 
GGGATAAGAA GCCAAAAACC CAGACGGGTA GCCAGCTATA AAAAAGGCAC TCTGGAATAC 
TTGCAGCTGA ATACCACAGA CAAGGAGAGC ACCTATTTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004954.2
CDS	138..3359
Translation	MKTLLLDLALWSLLFQPGWLSFSSQVSQNCHNGSYEISVLMMGNSAFAEPLKNLEDAVNEGLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLIGPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDLPFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTFEGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPNDITGRGPQILMIAVFTLTGAVVLLLLVALLMLRKYRKDYELRQKKWSHIPPENIFPLETNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQRLQAEFSDMIANSLQKRQAAGIRSQKPRRVASYKKGTLEYLQLNTTDKESTYF

Target ORF information:

RefSeq Version	NM_004963.3
Organism	Homo sapiens(human)
Definition	Homo sapiens guanylate cyclase 2C (GUCY2C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004963.3

ORF Insert Sequence:

ATGAAGACGT TGCTGTTGGA CTTGGCTTTG TGGTCACTGC TCTTCCAGCC CGGGTGGCTG 
TCCTTTAGTT CCCAGGTGAG TCAGAACTGC CACAATGGCA GCTATGAAAT CAGCGTCCTG 
ATGATGGGCA ACTCAGCCTT TGCAGAGCCC CTGAAAAACT TGGAAGATGC GGTGAATGAG 
GGGCTGGAAA TAGTGAGAGG ACGTCTGCAA AATGCTGGCC TAAATGTGAC TGTGAACGCT 
ACTTTCATGT ATTCGGATGG TCTGATTCAT AACTCAGGCG ACTGCCGGAG TAGCACCTGT 
GAAGGCCTCG ACCTACTCAG GAAAATTTCA AATGCACAAC GGATGGGCTG TGTCCTCATA 
GGGCCCTCAT GTACATACTC CACCTTCCAG ATGTACCTTG ACACAGAATT GAGCTACCCC 
ATGATCTCAG CTGGAAGTTT TGGATTGTCA TGTGACTATA AAGAAACCTT AACCAGGCTG 
ATGTCTCCAG CTAGAAAGTT GATGTACTTC TTGGTTAACT TTTGGAAAAC CAACGATCTG 
CCCTTCAAAA CTTATTCCTG GAGCACTTCG TATGTTTACA AGAATGGTAC AGAAACTGAG 
GACTGTTTCT GGTACCTTAA TGCTCTGGAG GCTAGCGTTT CCTATTTCTC CCACGAACTC 
GGCTTTAAGG TGGTGTTAAG ACAAGATAAG GAGTTTCAGG ATATCTTAAT GGACCACAAC 
AGGAAAAGCA ATGTGATTAT TATGTGTGGT GGTCCAGAGT TCCTCTACAA GCTGAAGGGT 
GACCGAGCAG TGGCTGAAGA CATTGTCATT ATTCTAGTGG ATCTTTTCAA TGACCAGTAC 
TTTGAGGACA ATGTCACAGC CCCTGACTAT ATGAAAAATG TCCTTGTTCT GACGCTGTCT 
CCTGGGAATT CCCTTCTAAA TAGCTCTTTC TCCAGGAATC TATCACCAAC AAAACGAGAC 
TTTGCTCTTG CCTATTTGAA TGGAATCCTG CTCTTTGGAC ATATGCTGAA GATATTTCTT 
GAAAATGGAG AAAATATTAC CACCCCCAAA TTTGCTCATG CTTTCAGGAA TCTCACTTTT 
GAAGGGTATG ACGGTCCAGT GACCTTGGAT GACTGGGGGG ATGTTGACAG TACCATGGTG 
CTTCTGTATA CCTCTGTGGA CACCAAGAAA TACAAGGTTC TTTTGACCTA TGATACCCAC 
GTAAATAAGA CCTATCCTGT GGATATGAGC CCCACATTCA CTTGGAAGAA CTCTAAACTT 
CCTAATGATA TTACAGGCCG GGGCCCTCAG ATCCTGATGA TTGCAGTCTT CACCCTCACT 
GGAGCTGTGG TGCTGCTCCT GCTCGTCGCT CTCCTGATGC TCAGAAAATA TAGAAAAGAT 
TATGAACTTC GTCAGAAAAA ATGGTCCCAC ATTCCTCCTG AAAATATCTT TCCTCTGGAG 
ACCAATGAGA CCAATCATGT TAGCCTCAAG ATCGATGATG ACAAAAGACG AGATACAATC 
CAGAGACTAC GACAGTGCAA ATACGACAAA AAGCGAGTGA TTCTCAAAGA TCTCAAGCAC 
AATGATGGTA ATTTCACTGA AAAACAGAAG ATAGAATTGA ACAAGTTGCT TCAGATTGAC 
TATTACAACC TGACCAAGTT CTACGGCACA GTGAAACTTG ATACCATGAT CTTCGGGGTG 
ATAGAATACT GTGAGAGAGG ATCCCTCCGG GAAGTTTTAA ATGACACAAT TTCCTACCCT 
GATGGCACAT TCATGGATTG GGAGTTTAAG ATCTCTGTCT TGTATGACAT TGCTAAGGGA 
ATGTCATATC TGCACTCCAG TAAGACAGAA GTCCATGGTC GTCTGAAATC TACCAACTGC 
GTAGTGGACA GTAGAATGGT GGTGAAGATC ACTGATTTTG GCTGCAATTC CATTTTACCT 
CCAAAAAAGG ACCTGTGGAC AGCTCCAGAG CACCTCCGCC AAGCCAACAT CTCTCAGAAA 
GGAGATGTGT ACAGCTATGG GATCATCGCA CAGGAGATCA TCCTGCGGAA AGAAACCTTC 
TACACTTTGA GCTGTCGGGA CCGGAATGAG AAGATTTTCA GAGTGGAAAA TTCCAATGGA 
ATGAAACCCT TCCGCCCAGA TTTATTCTTG GAAACAGCAG AGGAAAAAGA GCTAGAAGTG 
TACCTACTTG TAAAAAACTG TTGGGAGGAA GATCCAGAAA AGAGACCAGA TTTCAAAAAA 
ATTGAGACTA CACTTGCCAA GATATTTGGA CTTTTTCATG ACCAAAAAAA TGAAAGCTAT 
ATGGATACCT TGATCCGACG TCTACAGCTA TATTCTCGAA ACCTGGAACA TCTGGTAGAG 
GAAAGGACAC AGCTGTACAA GGCAGAGAGG GACAGGGCTG ACAGACTTAA CTTTATGTTG 
CTTCCAAGGC TAGTGGTAAA GTCTCTGAAG GAGAAAGGCT TTGTGGAGCC GGAACTATAT 
GAGGAAGTTA CAATCTACTT CAGTGACATT GTAGGTTTCA CTACTATCTG CAAATACAGC 
ACCCCCATGG AAGTGGTGGA CATGCTTAAT GACATCTATA AGAGTTTTGA CCACATTGTT 
GATCATCATG ATGTCTACAA GGTGGAAACC ATCGGTGATG CGTACATGGT GGCTAGTGGT 
TTGCCTAAGA GAAATGGCAA TCGGCATGCA ATAGACATTG CCAAGATGGC CTTGGAAATC 
CTCAGCTTCA TGGGGACCTT TGAGCTGGAG CATCTTCCTG GCCTCCCAAT ATGGATTCGC 
ATTGGAGTTC ACTCTGGTCC CTGTGCTGCT GGAGTTGTGG GAATCAAGAT GCCTCGTTAT 
TGTCTATTTG GAGATACGGT CAACACAGCC TCTAGGATGG AATCCACTGG CCTCCCTTTG 
AGAATTCACG TGAGTGGCTC CACCATAGCC ATCCTGAAGA GAACTGAGTG CCAGTTCCTT 
TATGAAGTGA GAGGAGAAAC ATACTTAAAG GGAAGAGGAA ATGAGACTAC CTACTGGCTG 
ACTGGGATGA AGGACCAGAA ATTCAACCTG CCAACCCCTC CTACTGTGGA GAATCAACAG 
CGTTTGCAAG CAGAATTTTC AGACATGATT GCCAACTCTT TACAGAAAAG ACAGGCAGCA 
GGGATAAGAA GCCAAAAACC CAGACGGGTA GCCAGCTATA AAAAAGGCAC TCTGGAATAC 
TTGCAGCTGA ATACCACAGA CAAGGAGAGC ACCTATTTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GUCY2C ( NM_004963.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004954.2 Homo sapiens guanylate cyclase 2C (GUCY2C), mRNA.

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CloneID	OHu14859
Clone ID Related Accession (Same CDS sequence)	NM_004963.3 , NM_004963.4
Accession Version	NM_004963.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3222bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573833600000
Organism	Homo sapiens(human)
Product	heat-stable enterotoxin receptor precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010168.6, AW848739.1, M73489.1, AC007545.13 and S57551.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004963.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M73489.1, S57551.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000261170.5/ ENSP00000261170.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGACGT TGCTGTTGGA CTTGGCTTTG TGGTCACTGC TCTTCCAGCC CGGGTGGCTG 
TCCTTTAGTT CCCAGGTGAG TCAGAACTGC CACAATGGCA GCTATGAAAT CAGCGTCCTG 
ATGATGGGCA ACTCAGCCTT TGCAGAGCCC CTGAAAAACT TGGAAGATGC GGTGAATGAG 
GGGCTGGAAA TAGTGAGAGG ACGTCTGCAA AATGCTGGCC TAAATGTGAC TGTGAACGCT 
ACTTTCATGT ATTCGGATGG TCTGATTCAT AACTCAGGCG ACTGCCGGAG TAGCACCTGT 
GAAGGCCTCG ACCTACTCAG GAAAATTTCA AATGCACAAC GGATGGGCTG TGTCCTCATA 
GGGCCCTCAT GTACATACTC CACCTTCCAG ATGTACCTTG ACACAGAATT GAGCTACCCC 
ATGATCTCAG CTGGAAGTTT TGGATTGTCA TGTGACTATA AAGAAACCTT AACCAGGCTG 
ATGTCTCCAG CTAGAAAGTT GATGTACTTC TTGGTTAACT TTTGGAAAAC CAACGATCTG 
CCCTTCAAAA CTTATTCCTG GAGCACTTCG TATGTTTACA AGAATGGTAC AGAAACTGAG 
GACTGTTTCT GGTACCTTAA TGCTCTGGAG GCTAGCGTTT CCTATTTCTC CCACGAACTC 
GGCTTTAAGG TGGTGTTAAG ACAAGATAAG GAGTTTCAGG ATATCTTAAT GGACCACAAC 
AGGAAAAGCA ATGTGATTAT TATGTGTGGT GGTCCAGAGT TCCTCTACAA GCTGAAGGGT 
GACCGAGCAG TGGCTGAAGA CATTGTCATT ATTCTAGTGG ATCTTTTCAA TGACCAGTAC 
TTTGAGGACA ATGTCACAGC CCCTGACTAT ATGAAAAATG TCCTTGTTCT GACGCTGTCT 
CCTGGGAATT CCCTTCTAAA TAGCTCTTTC TCCAGGAATC TATCACCAAC AAAACGAGAC 
TTTGCTCTTG CCTATTTGAA TGGAATCCTG CTCTTTGGAC ATATGCTGAA GATATTTCTT 
GAAAATGGAG AAAATATTAC CACCCCCAAA TTTGCTCATG CTTTCAGGAA TCTCACTTTT 
GAAGGGTATG ACGGTCCAGT GACCTTGGAT GACTGGGGGG ATGTTGACAG TACCATGGTG 
CTTCTGTATA CCTCTGTGGA CACCAAGAAA TACAAGGTTC TTTTGACCTA TGATACCCAC 
GTAAATAAGA CCTATCCTGT GGATATGAGC CCCACATTCA CTTGGAAGAA CTCTAAACTT 
CCTAATGATA TTACAGGCCG GGGCCCTCAG ATCCTGATGA TTGCAGTCTT CACCCTCACT 
GGAGCTGTGG TGCTGCTCCT GCTCGTCGCT CTCCTGATGC TCAGAAAATA TAGAAAAGAT 
TATGAACTTC GTCAGAAAAA ATGGTCCCAC ATTCCTCCTG AAAATATCTT TCCTCTGGAG 
ACCAATGAGA CCAATCATGT TAGCCTCAAG ATCGATGATG ACAAAAGACG AGATACAATC 
CAGAGACTAC GACAGTGCAA ATACGACAAA AAGCGAGTGA TTCTCAAAGA TCTCAAGCAC 
AATGATGGTA ATTTCACTGA AAAACAGAAG ATAGAATTGA ACAAGTTGCT TCAGATTGAC 
TATTACAACC TGACCAAGTT CTACGGCACA GTGAAACTTG ATACCATGAT CTTCGGGGTG 
ATAGAATACT GTGAGAGAGG ATCCCTCCGG GAAGTTTTAA ATGACACAAT TTCCTACCCT 
GATGGCACAT TCATGGATTG GGAGTTTAAG ATCTCTGTCT TGTATGACAT TGCTAAGGGA 
ATGTCATATC TGCACTCCAG TAAGACAGAA GTCCATGGTC GTCTGAAATC TACCAACTGC 
GTAGTGGACA GTAGAATGGT GGTGAAGATC ACTGATTTTG GCTGCAATTC CATTTTACCT 
CCAAAAAAGG ACCTGTGGAC AGCTCCAGAG CACCTCCGCC AAGCCAACAT CTCTCAGAAA 
GGAGATGTGT ACAGCTATGG GATCATCGCA CAGGAGATCA TCCTGCGGAA AGAAACCTTC 
TACACTTTGA GCTGTCGGGA CCGGAATGAG AAGATTTTCA GAGTGGAAAA TTCCAATGGA 
ATGAAACCCT TCCGCCCAGA TTTATTCTTG GAAACAGCAG AGGAAAAAGA GCTAGAAGTG 
TACCTACTTG TAAAAAACTG TTGGGAGGAA GATCCAGAAA AGAGACCAGA TTTCAAAAAA 
ATTGAGACTA CACTTGCCAA GATATTTGGA CTTTTTCATG ACCAAAAAAA TGAAAGCTAT 
ATGGATACCT TGATCCGACG TCTACAGCTA TATTCTCGAA ACCTGGAACA TCTGGTAGAG 
GAAAGGACAC AGCTGTACAA GGCAGAGAGG GACAGGGCTG ACAGACTTAA CTTTATGTTG 
CTTCCAAGGC TAGTGGTAAA GTCTCTGAAG GAGAAAGGCT TTGTGGAGCC GGAACTATAT 
GAGGAAGTTA CAATCTACTT CAGTGACATT GTAGGTTTCA CTACTATCTG CAAATACAGC 
ACCCCCATGG AAGTGGTGGA CATGCTTAAT GACATCTATA AGAGTTTTGA CCACATTGTT 
GATCATCATG ATGTCTACAA GGTGGAAACC ATCGGTGATG CGTACATGGT GGCTAGTGGT 
TTGCCTAAGA GAAATGGCAA TCGGCATGCA ATAGACATTG CCAAGATGGC CTTGGAAATC 
CTCAGCTTCA TGGGGACCTT TGAGCTGGAG CATCTTCCTG GCCTCCCAAT ATGGATTCGC 
ATTGGAGTTC ACTCTGGTCC CTGTGCTGCT GGAGTTGTGG GAATCAAGAT GCCTCGTTAT 
TGTCTATTTG GAGATACGGT CAACACAGCC TCTAGGATGG AATCCACTGG CCTCCCTTTG 
AGAATTCACG TGAGTGGCTC CACCATAGCC ATCCTGAAGA GAACTGAGTG CCAGTTCCTT 
TATGAAGTGA GAGGAGAAAC ATACTTAAAG GGAAGAGGAA ATGAGACTAC CTACTGGCTG 
ACTGGGATGA AGGACCAGAA ATTCAACCTG CCAACCCCTC CTACTGTGGA GAATCAACAG 
CGTTTGCAAG CAGAATTTTC AGACATGATT GCCAACTCTT TACAGAAAAG ACAGGCAGCA 
GGGATAAGAA GCCAAAAACC CAGACGGGTA GCCAGCTATA AAAAAGGCAC TCTGGAATAC 
TTGCAGCTGA ATACCACAGA CAAGGAGAGC ACCTATTTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004954.2
CDS	152..3373
Translation	MKTLLLDLALWSLLFQPGWLSFSSQVSQNCHNGSYEISVLMMGNSAFAEPLKNLEDAVNEGLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLIGPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDLPFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTFEGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPNDITGRGPQILMIAVFTLTGAVVLLLLVALLMLRKYRKDYELRQKKWSHIPPENIFPLETNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQRLQAEFSDMIANSLQKRQAAGIRSQKPRRVASYKKGTLEYLQLNTTDKESTYF

Target ORF information:

RefSeq Version	NM_004963.4
Organism	Homo sapiens(human)
Definition	Homo sapiens guanylate cyclase 2C (GUCY2C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004963.4

ORF Insert Sequence:

ATGAAGACGT TGCTGTTGGA CTTGGCTTTG TGGTCACTGC TCTTCCAGCC CGGGTGGCTG 
TCCTTTAGTT CCCAGGTGAG TCAGAACTGC CACAATGGCA GCTATGAAAT CAGCGTCCTG 
ATGATGGGCA ACTCAGCCTT TGCAGAGCCC CTGAAAAACT TGGAAGATGC GGTGAATGAG 
GGGCTGGAAA TAGTGAGAGG ACGTCTGCAA AATGCTGGCC TAAATGTGAC TGTGAACGCT 
ACTTTCATGT ATTCGGATGG TCTGATTCAT AACTCAGGCG ACTGCCGGAG TAGCACCTGT 
GAAGGCCTCG ACCTACTCAG GAAAATTTCA AATGCACAAC GGATGGGCTG TGTCCTCATA 
GGGCCCTCAT GTACATACTC CACCTTCCAG ATGTACCTTG ACACAGAATT GAGCTACCCC 
ATGATCTCAG CTGGAAGTTT TGGATTGTCA TGTGACTATA AAGAAACCTT AACCAGGCTG 
ATGTCTCCAG CTAGAAAGTT GATGTACTTC TTGGTTAACT TTTGGAAAAC CAACGATCTG 
CCCTTCAAAA CTTATTCCTG GAGCACTTCG TATGTTTACA AGAATGGTAC AGAAACTGAG 
GACTGTTTCT GGTACCTTAA TGCTCTGGAG GCTAGCGTTT CCTATTTCTC CCACGAACTC 
GGCTTTAAGG TGGTGTTAAG ACAAGATAAG GAGTTTCAGG ATATCTTAAT GGACCACAAC 
AGGAAAAGCA ATGTGATTAT TATGTGTGGT GGTCCAGAGT TCCTCTACAA GCTGAAGGGT 
GACCGAGCAG TGGCTGAAGA CATTGTCATT ATTCTAGTGG ATCTTTTCAA TGACCAGTAC 
TTTGAGGACA ATGTCACAGC CCCTGACTAT ATGAAAAATG TCCTTGTTCT GACGCTGTCT 
CCTGGGAATT CCCTTCTAAA TAGCTCTTTC TCCAGGAATC TATCACCAAC AAAACGAGAC 
TTTGCTCTTG CCTATTTGAA TGGAATCCTG CTCTTTGGAC ATATGCTGAA GATATTTCTT 
GAAAATGGAG AAAATATTAC CACCCCCAAA TTTGCTCATG CTTTCAGGAA TCTCACTTTT 
GAAGGGTATG ACGGTCCAGT GACCTTGGAT GACTGGGGGG ATGTTGACAG TACCATGGTG 
CTTCTGTATA CCTCTGTGGA CACCAAGAAA TACAAGGTTC TTTTGACCTA TGATACCCAC 
GTAAATAAGA CCTATCCTGT GGATATGAGC CCCACATTCA CTTGGAAGAA CTCTAAACTT 
CCTAATGATA TTACAGGCCG GGGCCCTCAG ATCCTGATGA TTGCAGTCTT CACCCTCACT 
GGAGCTGTGG TGCTGCTCCT GCTCGTCGCT CTCCTGATGC TCAGAAAATA TAGAAAAGAT 
TATGAACTTC GTCAGAAAAA ATGGTCCCAC ATTCCTCCTG AAAATATCTT TCCTCTGGAG 
ACCAATGAGA CCAATCATGT TAGCCTCAAG ATCGATGATG ACAAAAGACG AGATACAATC 
CAGAGACTAC GACAGTGCAA ATACGACAAA AAGCGAGTGA TTCTCAAAGA TCTCAAGCAC 
AATGATGGTA ATTTCACTGA AAAACAGAAG ATAGAATTGA ACAAGTTGCT TCAGATTGAC 
TATTACAACC TGACCAAGTT CTACGGCACA GTGAAACTTG ATACCATGAT CTTCGGGGTG 
ATAGAATACT GTGAGAGAGG ATCCCTCCGG GAAGTTTTAA ATGACACAAT TTCCTACCCT 
GATGGCACAT TCATGGATTG GGAGTTTAAG ATCTCTGTCT TGTATGACAT TGCTAAGGGA 
ATGTCATATC TGCACTCCAG TAAGACAGAA GTCCATGGTC GTCTGAAATC TACCAACTGC 
GTAGTGGACA GTAGAATGGT GGTGAAGATC ACTGATTTTG GCTGCAATTC CATTTTACCT 
CCAAAAAAGG ACCTGTGGAC AGCTCCAGAG CACCTCCGCC AAGCCAACAT CTCTCAGAAA 
GGAGATGTGT ACAGCTATGG GATCATCGCA CAGGAGATCA TCCTGCGGAA AGAAACCTTC 
TACACTTTGA GCTGTCGGGA CCGGAATGAG AAGATTTTCA GAGTGGAAAA TTCCAATGGA 
ATGAAACCCT TCCGCCCAGA TTTATTCTTG GAAACAGCAG AGGAAAAAGA GCTAGAAGTG 
TACCTACTTG TAAAAAACTG TTGGGAGGAA GATCCAGAAA AGAGACCAGA TTTCAAAAAA 
ATTGAGACTA CACTTGCCAA GATATTTGGA CTTTTTCATG ACCAAAAAAA TGAAAGCTAT 
ATGGATACCT TGATCCGACG TCTACAGCTA TATTCTCGAA ACCTGGAACA TCTGGTAGAG 
GAAAGGACAC AGCTGTACAA GGCAGAGAGG GACAGGGCTG ACAGACTTAA CTTTATGTTG 
CTTCCAAGGC TAGTGGTAAA GTCTCTGAAG GAGAAAGGCT TTGTGGAGCC GGAACTATAT 
GAGGAAGTTA CAATCTACTT CAGTGACATT GTAGGTTTCA CTACTATCTG CAAATACAGC 
ACCCCCATGG AAGTGGTGGA CATGCTTAAT GACATCTATA AGAGTTTTGA CCACATTGTT 
GATCATCATG ATGTCTACAA GGTGGAAACC ATCGGTGATG CGTACATGGT GGCTAGTGGT 
TTGCCTAAGA GAAATGGCAA TCGGCATGCA ATAGACATTG CCAAGATGGC CTTGGAAATC 
CTCAGCTTCA TGGGGACCTT TGAGCTGGAG CATCTTCCTG GCCTCCCAAT ATGGATTCGC 
ATTGGAGTTC ACTCTGGTCC CTGTGCTGCT GGAGTTGTGG GAATCAAGAT GCCTCGTTAT 
TGTCTATTTG GAGATACGGT CAACACAGCC TCTAGGATGG AATCCACTGG CCTCCCTTTG 
AGAATTCACG TGAGTGGCTC CACCATAGCC ATCCTGAAGA GAACTGAGTG CCAGTTCCTT 
TATGAAGTGA GAGGAGAAAC ATACTTAAAG GGAAGAGGAA ATGAGACTAC CTACTGGCTG 
ACTGGGATGA AGGACCAGAA ATTCAACCTG CCAACCCCTC CTACTGTGGA GAATCAACAG 
CGTTTGCAAG CAGAATTTTC AGACATGATT GCCAACTCTT TACAGAAAAG ACAGGCAGCA 
GGGATAAGAA GCCAAAAACC CAGACGGGTA GCCAGCTATA AAAAAGGCAC TCTGGAATAC 
TTGCAGCTGA ATACCACAGA CAAGGAGAGC ACCTATTTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C-linked familial diarrhea.
Scandinavian journal of gastroenterology53(10-11)1264-1273(2018 Oct - Nov)
Tronstad RR,Polushina T,Brattbakk HR,Stansberg C,von Volkmann HL,Hanevik K,Ellinghaus E,Jørgensen SF,Ersland KM,Pham KD,Gilja OH,Hovdenak N,Hausken T,Vatn MH,Franke A,Knappskog PM,Le Hellard S,Karlsen TH,Fiskerstrand T

Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases.
Cancer immunology research6(5)509-516(2018 05)
Magee MS,Abraham TS,Baybutt TR,Flickinger JC Jr,Ridge NA,Marszalowicz GP,Prajapati P,Hersperger AR,Waldman SA,Snook AE

Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease.
Inflammatory bowel diseases23(10)1752-1761(2017 10)
Tronstad RR,Kummen M,Holm K,von Volkmann HL,Anmarkrud JA,Høivik ML,Moum B,Gilja OH,Hausken T,Baines J,Karlsen TH,Fiskerstrand T,Hov JR

Consistent expression of guanylyl cyclase-C in primary and metastatic gastrointestinal cancers.
PloS one12(12)e0189953(2017)
Danaee H,Kalebic T,Wyant T,Fassan M,Mescoli C,Gao F,Trepicchio WL,Rugge M

Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation.
PloS one12(9)e0185496(2017)
von Volkmann HL,Brønstad I,Gilja OH,R Tronstad R,Sangnes DA,Nortvedt R,Hausken T,Dimcevski G,Fiskerstrand T,Nylund K

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GUCY2C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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