Fadd cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fadd
Entrez Gene ID	14082
Full Name	Fas (TNFRSF6)-associated via death domain
Synonyms	Mort1/FADD
General protein information	Preferred Names Fas (TNFRSF6)-associated via death domain Names FAS-associated death domain protein FAS-associating death domain-containing protein Fas-associating protein with death domain mediator of receptor induced toxicity protein FADD
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 F5\|7 88.85 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010175.6	NP_034305.1	FAS-associated death domain protein
NM_010175.5	NP_034305.1	FAS-associated death domain protein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	FADD	NP_001007817.1
Xenopus tropicalis (tropical clawed frog)	fadd	XP_002934114.1
Mus musculus (house mouse)	Fadd	NP_034305.1
Macaca mulatta (Rhesus monkey)	LOC708606	XP_001100468.1
Rattus norvegicus (Norway rat)	Fadd	NP_690920.1
Gallus gallus (chicken)	FADD	XP_421073.2
Homo sapiens (human)	FADD	NP_003815.1
Pan troglodytes (chimpanzee)	FADD	XP_508611.2
Danio rerio (zebrafish)	fadd	XP_001923893.1

Gene Ontology
Bibliography

Related articles in PubMed

K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation.
Tang Y, Tu H, Zhang J, Zhao X, Wang Y, Qin J, Lin X
Nature communications10(1)4157(2019 09)

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.
Zhang X, Zhang H, Xu C, Li X, Li M, Wu X, Pu W, Zhou B, Wang H, Li D, Ding Q, Ying H, Wang H, Zhang H
Nature communications10(1)4158(2019 09)

Ferroptosis as a target for protection against cardiomyopathy.
Fang X, Wang H, Han D, Xie E, Yang X, Wei J, Gu S, Gao F, Zhu N, Yin X, Cheng Q, Zhang P, Dai W, Chen J, Yang F, Yang HT, Linkermann A, Gu W, Min J, Wang F
Proceedings of the National Academy of Sciences of the United States of America116(7)2672-2680(2019 02)

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation.
Lafont E, Draber P, Rieser E, Reichert M, Kupka S, de Miguel D, Draberova H, von Mässenhausen A, Bhamra A, Henderson S, Wojdyla K, Chalk A, Surinova S, Linkermann A, Walczak H
Nature cell biology20(12)1389-1399(2018 12)

Dominant Negative FADD/MORT1 Inhibits the Development of Intestinal Intraepithelial Lymphocytes With a Marked Defect on CD8αα+TCRγδ+ T Cells.
Zhang X, Huo L, Song L, Hu Z, Wang X, Han Y, Wang Y, Xu P, Zhang J, Hua ZC
Frontiers in immunology92038(2018)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Fadd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fadd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19589	NM_010175.6 Latest version!	Mus musculus Fas (TNFRSF6)-associated via death domain (Fadd), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
View Old Accession Versions >>
OMu19589	NM_010175.5	Mus musculus Fas (TNFRSF6)-associated via death domain (Fadd), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fadd ( NM_010175.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034305.1 Mus musculus Fas (TNFRSF6)-associated via death domain (Fadd), mRNA.

Price & Availability↑

CloneID	OMu19589
Clone ID Related Accession (Same CDS sequence)	NM_010175.6 , NM_010175.5
Accession Version	NM_010175.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1511798400000
Organism	Mus musculus(house mouse)
Product	FAS-associated death domain protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC153792.4. On Oct 19, 2007 this sequence version replaced NM_010175.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK169798.1, AK084808.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGACCCAT TCCTGGTGCT GCTGCACTCG CTGTCCGGCA GCCTGTCGGG CAACGATCTG 
ATGGAGCTCA AGTTCTTGTG CCGCGAGCGC GTGAGCAAAC GAAAGCTGGA GCGCGTGCAG 
AGTGGCCTGG ACCTGTTCAC GGTGCTGCTG GAGCAGAACG ACCTGGAGCG CGGGCACACC 
GGGCTGCTGC GCGAGTTGCT GGCCTCGCTG CGCCGACACG ATCTACTGCA GCGCCTGGAC 
GACTTCGAGG CGGGGACGGC GACCGCTGCG CCCCCGGGGG AGGCAGATCT GCAGGTGGCA 
TTTGACATTG TGTGTGACAA TGTGGGGAGA GACTGGAAAA GACTGGCCCG CGAGCTGAAG 
GTGTCTGAGG CCAAGATGGA TGGGATTGAG GAGAAGTACC CCCGAAGTCT GAGTGAGCGG 
GTAAGGGAGA GTCTGAAAGT CTGGAAGAAT GCTGAGAAGA AGAACGCCTC GGTGGCCGGA 
CTGGTTAAGG CGCTGCGGAC CTGCAGGCTG AATCTGGTGG CTGACCTGGT GGAAGAAGCC 
CAGGAATCTG TGAGCAAGAG TGAGAATATG TCCCCAGTAC TAAGGGATTC AACTGTGTCT 
TCCTCAGAAA CACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034305.1
CDS	48..665
Translation	MDPFLVLLHSLSGSLSGNDLMELKFLCRERVSKRKLERVQSGLDLFTVLLEQNDLERGHTGLLRELLASLRRHDLLQRLDDFEAGTATAAPPGEADLQVAFDIVCDNVGRDWKRLARELKVSEAKMDGIEEKYPRSLSERVRESLKVWKNAEKKNASVAGLVKALRTCRLNLVADLVEEAQESVSKSENMSPVLRDSTVSSSETP

Target ORF information:

RefSeq Version	NM_010175.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus Fas (TNFRSF6)-associated via death domain (Fadd), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010175.5

ORF Insert Sequence:

ATGGACCCAT TCCTGGTGCT GCTGCACTCG CTGTCCGGCA GCCTGTCGGG CAACGATCTG 
ATGGAGCTCA AGTTCTTGTG CCGCGAGCGC GTGAGCAAAC GAAAGCTGGA GCGCGTGCAG 
AGTGGCCTGG ACCTGTTCAC GGTGCTGCTG GAGCAGAACG ACCTGGAGCG CGGGCACACC 
GGGCTGCTGC GCGAGTTGCT GGCCTCGCTG CGCCGACACG ATCTACTGCA GCGCCTGGAC 
GACTTCGAGG CGGGGACGGC GACCGCTGCG CCCCCGGGGG AGGCAGATCT GCAGGTGGCA 
TTTGACATTG TGTGTGACAA TGTGGGGAGA GACTGGAAAA GACTGGCCCG CGAGCTGAAG 
GTGTCTGAGG CCAAGATGGA TGGGATTGAG GAGAAGTACC CCCGAAGTCT GAGTGAGCGG 
GTAAGGGAGA GTCTGAAAGT CTGGAAGAAT GCTGAGAAGA AGAACGCCTC GGTGGCCGGA 
CTGGTTAAGG CGCTGCGGAC CTGCAGGCTG AATCTGGTGG CTGACCTGGT GGAAGAAGCC 
CAGGAATCTG TGAGCAAGAG TGAGAATATG TCCCCAGTAC TAAGGGATTC AACTGTGTCT 
TCCTCAGAAA CACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fadd ( NM_010175.6 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034305.1 Mus musculus Fas (TNFRSF6)-associated via death domain (Fadd), mRNA.

Price & Availability↑

CloneID	OMu19589
Clone ID Related Accession (Same CDS sequence)	NM_010175.6 , NM_010175.5
Accession Version	NM_010175.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1576425600000
Organism	Mus musculus(house mouse)
Product	FAS-associated death domain protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC153792.4. On Jun 3, 2018 this sequence version replaced NM_010175.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK169798.1, AK084808.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCCAT TCCTGGTGCT GCTGCACTCG CTGTCCGGCA GCCTGTCGGG CAACGATCTG 
ATGGAGCTCA AGTTCTTGTG CCGCGAGCGC GTGAGCAAAC GAAAGCTGGA GCGCGTGCAG 
AGTGGCCTGG ACCTGTTCAC GGTGCTGCTG GAGCAGAACG ACCTGGAGCG CGGGCACACC 
GGGCTGCTGC GCGAGTTGCT GGCCTCGCTG CGCCGACACG ATCTACTGCA GCGCCTGGAC 
GACTTCGAGG CGGGGACGGC GACCGCTGCG CCCCCGGGGG AGGCAGATCT GCAGGTGGCA 
TTTGACATTG TGTGTGACAA TGTGGGGAGA GACTGGAAAA GACTGGCCCG CGAGCTGAAG 
GTGTCTGAGG CCAAGATGGA TGGGATTGAG GAGAAGTACC CCCGAAGTCT GAGTGAGCGG 
GTAAGGGAGA GTCTGAAAGT CTGGAAGAAT GCTGAGAAGA AGAACGCCTC GGTGGCCGGA 
CTGGTTAAGG CGCTGCGGAC CTGCAGGCTG AATCTGGTGG CTGACCTGGT GGAAGAAGCC 
CAGGAATCTG TGAGCAAGAG TGAGAATATG TCCCCAGTAC TAAGGGATTC AACTGTGTCT 
TCCTCAGAAA CACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034305.1
CDS	53..670
Translation	MDPFLVLLHSLSGSLSGNDLMELKFLCRERVSKRKLERVQSGLDLFTVLLEQNDLERGHTGLLRELLASLRRHDLLQRLDDFEAGTATAAPPGEADLQVAFDIVCDNVGRDWKRLARELKVSEAKMDGIEEKYPRSLSERVRESLKVWKNAEKKNASVAGLVKALRTCRLNLVADLVEEAQESVSKSENMSPVLRDSTVSSSETP

Target ORF information:

RefSeq Version	NM_010175.6
Organism	Mus musculus(house mouse)
Definition	Mus musculus Fas (TNFRSF6)-associated via death domain (Fadd), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010175.6

ORF Insert Sequence:

ATGGACCCAT TCCTGGTGCT GCTGCACTCG CTGTCCGGCA GCCTGTCGGG CAACGATCTG 
ATGGAGCTCA AGTTCTTGTG CCGCGAGCGC GTGAGCAAAC GAAAGCTGGA GCGCGTGCAG 
AGTGGCCTGG ACCTGTTCAC GGTGCTGCTG GAGCAGAACG ACCTGGAGCG CGGGCACACC 
GGGCTGCTGC GCGAGTTGCT GGCCTCGCTG CGCCGACACG ATCTACTGCA GCGCCTGGAC 
GACTTCGAGG CGGGGACGGC GACCGCTGCG CCCCCGGGGG AGGCAGATCT GCAGGTGGCA 
TTTGACATTG TGTGTGACAA TGTGGGGAGA GACTGGAAAA GACTGGCCCG CGAGCTGAAG 
GTGTCTGAGG CCAAGATGGA TGGGATTGAG GAGAAGTACC CCCGAAGTCT GAGTGAGCGG 
GTAAGGGAGA GTCTGAAAGT CTGGAAGAAT GCTGAGAAGA AGAACGCCTC GGTGGCCGGA 
CTGGTTAAGG CGCTGCGGAC CTGCAGGCTG AATCTGGTGG CTGACCTGGT GGAAGAAGCC 
CAGGAATCTG TGAGCAAGAG TGAGAATATG TCCCCAGTAC TAAGGGATTC AACTGTGTCT 
TCCTCAGAAA CACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation.
Nature communications10(1)4157(2019 09)
Tang Y,Tu H,Zhang J,Zhao X,Wang Y,Qin J,Lin X

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.
Nature communications10(1)4158(2019 09)
Zhang X,Zhang H,Xu C,Li X,Li M,Wu X,Pu W,Zhou B,Wang H,Li D,Ding Q,Ying H,Wang H,Zhang H

Ferroptosis as a target for protection against cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America116(7)2672-2680(2019 02)
Fang X,Wang H,Han D,Xie E,Yang X,Wei J,Gu S,Gao F,Zhu N,Yin X,Cheng Q,Zhang P,Dai W,Chen J,Yang F,Yang HT,Linkermann A,Gu W,Min J,Wang F

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation.
Nature cell biology20(12)1389-1399(2018 12)
Lafont E,Draber P,Rieser E,Reichert M,Kupka S,de Miguel D,Draberova H,von Mässenhausen A,Bhamra A,Henderson S,Wojdyla K,Chalk A,Surinova S,Linkermann A,Walczak H

Dominant Negative FADD/MORT1 Inhibits the Development of Intestinal Intraepithelial Lymphocytes With a Marked Defect on CD8αα+TCRγδ+ T Cells.
Frontiers in immunology92038(2018)
Zhang X,Huo L,Song L,Hu Z,Wang X,Han Y,Wang Y,Xu P,Zhang J,Hua ZC

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Fadd cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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