| Gene Symbol | LSM8 |
| Entrez Gene ID | 51691 |
| Full Name | LSM8 homolog, U6 small nuclear RNA associated |
| Synonyms | NAA38 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a member of the like-Sm family of proteins. The encoded protein consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus. [provided by RefSeq, Jan 2010]. |
| Disorder MIM: |
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LSM8 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following LSM8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LSM8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu29972 Clone ID Related Accession (Same CDS sequence) NM_016200.5 , NM_016200.4 Accession Version NM_016200.5 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 291bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1570636800000 Organism Homo sapiens(human) Product LSM8 homolog, U6 small nuclear RNA associated Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA478457.1 and AC006389.2. On Nov 23, 2018 this sequence version replaced NM_016200.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA247272.1, SRR1803617.184135.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000249299.7/ ENSP00000249299.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241ATGACGTCCG CTTTGGAGAA CTACATCAAC CGAACTGTTG CCGTTATTAC ATCAGATGGG
AGAATGATTG TGGGAACACT GAAAGGTTTT GACCAGACCA TTAATTTGAT TTTGGATGAA
AGCCATGAAC GAGTATTCAG CTCTTCACAG GGGGTAGAAC AAGTGGTACT AGGATTATAC
ATTGTAAGAG GTGACAACGT TGCAGTCATT GGAGAAATCG ATGAAGAAAC AGATTCTGCG
CTTGATTTGG GGAATATTCG AGCAGAACCT TTAAATTCTG TAGCACACTG AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_057284.1 CDS 61..351 Translation 
Target ORF information:
RefSeq Version NM_016200.5 Organism Homo sapiens(human) Definition Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (LSM8), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_016200.5
ORF Insert Sequence:
1
61
121
181
241ATGACGTCCG CTTTGGAGAA CTACATCAAC CGAACTGTTG CCGTTATTAC ATCAGATGGG
AGAATGATTG TGGGAACACT GAAAGGTTTT GACCAGACCA TTAATTTGAT TTTGGATGAA
AGCCATGAAC GAGTATTCAG CTCTTCACAG GGGGTAGAAC AAGTGGTACT AGGATTATAC
ATTGTAAGAG GTGACAACGT TGCAGTCATT GGAGAAATCG ATGAAGAAAC AGATTCTGCG
CTTGATTTGG GGAATATTCG AGCAGAACCT TTAAATTCTG TAGCACACTG AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu29972 Clone ID Related Accession (Same CDS sequence) NM_016200.5 , NM_016200.4 Accession Version NM_016200.4 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 291bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1506787200000 Organism Homo sapiens(human) Product LSM8 homolog, U6 small nuclear RNA associated Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006389.2 and DA478457.1. On Jan 21, 2010 this sequence version replaced NM_016200.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB275674.1, SRR1803617.184135.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241ATGACGTCCG CTTTGGAGAA CTACATCAAC CGAACTGTTG CCGTTATTAC ATCAGATGGG
AGAATGATTG TGGGAACACT GAAAGGTTTT GACCAGACCA TTAATTTGAT TTTGGATGAA
AGCCATGAAC GAGTATTCAG CTCTTCACAG GGGGTAGAAC AAGTGGTACT AGGATTATAC
ATTGTAAGAG GTGACAACGT TGCAGTCATT GGAGAAATCG ATGAAGAAAC AGATTCTGCG
CTTGATTTGG GGAATATTCG AGCAGAACCT TTAAATTCTG TAGCACACTG AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_057284.1 CDS 193..483 Translation
Target ORF information:
RefSeq Version NM_016200.4 Organism Homo sapiens(human) Definition Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (LSM8), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_016200.4
ORF Insert Sequence:
1
61
121
181
241ATGACGTCCG CTTTGGAGAA CTACATCAAC CGAACTGTTG CCGTTATTAC ATCAGATGGG
AGAATGATTG TGGGAACACT GAAAGGTTTT GACCAGACCA TTAATTTGAT TTTGGATGAA
AGCCATGAAC GAGTATTCAG CTCTTCACAG GGGGTAGAAC AAGTGGTACT AGGATTATAC
ATTGTAAGAG GTGACAACGT TGCAGTCATT GGAGAAATCG ATGAAGAAAC AGATTCTGCG
CTTGATTTGG GGAATATTCG AGCAGAACCT TTAAATTCTG TAGCACACTG AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Cell170(4)701-713.e11(2017 Aug)
Bertram K,Agafonov DE,Dybkov O,Haselbach D,Leelaram MN,Will CL,Urlaub H,Kastner B,Lührmann R,Stark H
Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW
Molecular architecture of the human U4/U6.U5 tri-snRNP.
Science (New York, N.Y.)351(6280)1416-20(2016 Mar)
Agafonov DE,Kastner B,Dybkov O,Hofele RV,Liu WT,Urlaub H,Lührmann R,Stark H
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
The pharmacogenomics journal14(4)356-64(2014 Aug)
Cobb J,Cule E,Moncrieffe H,Hinks A,Ursu S,Patrick F,Kassoumeri L,Flynn E,Bulatović M,Wulffraat N,van Zelst B,de Jonge R,Bohm M,Dolezalova P,Hirani S,Newman S,Whitworth P,Southwood TR,De Iorio M,,,,Wedderburn LR,Thomson W
Nuclear LSm8 affects number of cytoplasmic processing bodies via controlling cellular distribution of Like-Sm proteins.
Molecular biology of the cell23(19)3776-85(2012 Oct)
Novotny I,Podolská K,Blazíková M,Valásek LS,Svoboda P,Stanek D
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