CEBPD cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CEBPD
Entrez Gene ID	1052
Full Name	CCAAT/enhancer binding protein delta
Synonyms	C/EBP-delta,CELF,CRP3,NF-IL6-beta
General protein information	Preferred Names CCAAT/enhancer binding protein delta Names CCAAT/enhancer-binding protein delta CCAAT/enhancer binding protein (C/EBP), delta c/EBP delta nuclear factor NF-IL6-beta
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q11.21
Summary	The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010].
Disorder MIM:	116898

mRNA and Protein(s)

mRNA	Protein	Name
NM_005195.3	NP_005186.2	CCAAT/enhancer-binding protein delta
NM_005195.4	NP_005186.2	CCAAT/enhancer-binding protein delta

Pathways from BioSystems

Homologies

Homo sapiens (human)	CEBPD	NP_005186.2
Rattus norvegicus (Norway rat)	Cebpd	NP_037286.1
Pan troglodytes (chimpanzee)	CEBPD	XP_003951307.1
Danio rerio (zebrafish)	cebpd	NP_571962.1
Mus musculus (house mouse)	Cebpd	NP_031705.3
Xenopus tropicalis (tropical clawed frog)	cebpd	NP_001025585.1
Canis lupus familiaris (dog)	CEBPD	XP_848281.1
Bos taurus (cattle)	CEBPD	NP_776692.2

Gene Ontology
Bibliography

Related articles in PubMed

CCAAT/enhancer binding protein delta (C/EBPδ) demonstrates a dichotomous role in tumour initiation and promotion of epithelial carcinoma.
Sowamber R, Chehade R, Bitar M, Dodds LV, Milea A, Slomovitz B, Shaw PA, George SHL
EBioMedicine44261-274(2019 Jun)

C/EBPδ links IL-6 and HIF-1 signaling to promote breast cancer stem cell-associated phenotypes.
Balamurugan K, Mendoza-Villanueva D, Sharan S, Summers GH, Dobrolecki LE, Lewis MT, Sterneck E
Oncogene38(20)3765-3780(2019 05)

Action and clinical significance of CCAAT/enhancer-binding protein delta in hepatocellular carcinoma.
Liu P, Cao W, Ma B, Li M, Chen K, Sideras K, Duitman JW, Sprengers D, Khe Tran TC, Ijzermans JNM, Biermann K, Verheij J, Spek CA, Kwekkeboom J, Pan Q, Peppelenbosch MP
Carcinogenesis40(1)155-163(2019 03)

Gemcabene, a first-in-class lipid-lowering agent in late-stage development, down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism.
Srivastava RAK, Cornicelli JA, Markham B, Bisgaier CL
Molecular and cellular biochemistry449(1-2)167-183(2018 Dec)

C/EBPδ drives interactions between human MAIT cells and endothelial cells that are important for extravasation.
Lee CH, Zhang HH, Singh SP, Koo L, Kabat J, Tsang H, Singh TP, Farber JM
eLife7(2018 02)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CEBPD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CEBPD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17203	NM_005195.4 Latest version!	Homo sapiens CCAAT enhancer binding protein delta (CEBPD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu17203	NM_005195.3	Homo sapiens CCAAT enhancer binding protein delta (CEBPD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CEBPD ( NM_005195.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005186.2 Homo sapiens CCAAT enhancer binding protein delta (CEBPD), mRNA.

Price & Availability↑

CloneID	OHu17203
Clone ID Related Accession (Same CDS sequence)	NM_005195.3 , NM_005195.4
Accession Version	NM_005195.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550246400000
Organism	Homo sapiens(human)
Product	CCAAT/enhancer-binding protein delta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M83667.1, BC105109.1 and BQ773696.1. On Feb 14, 2007 this sequence version replaced NM_005195.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: full length.

ATGAGCGCCG CGCTCTTCAG CCTGGACGGC CCGGCGCGCG GCGCGCCCTG GCCTGCGGAG 
CCTGCGCCCT TCTACGAACC GGGCCGGGCG GGCAAGCCGG GCCGCGGGGC CGAGCCAGGG 
GCCCTAGGCG AGCCAGGCGC CGCCGCCCCC GCCATGTACG ACGACGAGAG CGCCATCGAC 
TTCAGCGCCT ACATCGACTC CATGGCCGCC GTGCCCACCC TGGAGCTGTG CCACGACGAG 
CTCTTCGCCG ACCTCTTCAA CAGCAATCAC AAGGCGGGCG GCGCGGGGCC CCTGGAGCTT 
CTTCCCGGCG GCCCCGCGCG CCCCTTGGGC CCGGGCCCTG CCGCTCCCCG CCTGCTCAAG 
CGCGAGCCCG ACTGGGGCGA CGGCGACGCG CCCGGCTCGC TGTTGCCCGC GCAGGTGGCC 
GCGTGCGCAC AGACCGTGGT GAGCTTGGCG GCCGCAGGGC AGCCCACCCC GCCCACGTCG 
CCGGAGCCGC CGCGCAGCAG CCCCAGGCAG ACCCCCGCGC CCGGCCCCGC CCGGGAGAAG 
AGCGCCGGCA AGAGGGGCCC GGACCGCGGC AGCCCCGAGT ACCGGCAGCG GCGCGAGCGC 
AACAACATCG CCGTGCGCAA GAGCCGCGAC AAGGCCAAGC GGCGCAACCA GGAGATGCAG 
CAGAAGTTGG TGGAGCTGTC GGCTGAGAAC GAGAAGCTGC ACCAGCGCGT GGAGCAGCTC 
ACGCGGGACC TGGCCGGCCT CCGGCAGTTC TTCAAGCAGC TGCCCAGCCC GCCCTTCCTG 
CCGGCCGCCG GGACAGCAGA CTGCCGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005186.2
CDS	45..854
Translation	MSAALFSLDGPARGAPWPAEPAPFYEPGRAGKPGRGAEPGALGEPGAAAPAMYDDESAIDFSAYIDSMAAVPTLELCHDELFADLFNSNHKAGGAGPLELLPGGPARPLGPGPAAPRLLKREPDWGDGDAPGSLLPAQVAACAQTVVSLAAAGQPTPPTSPEPPRSSPRQTPAPGPAREKSAGKRGPDRGSPEYRQRRERNNIAVRKSRDKAKRRNQEMQQKLVELSAENEKLHQRVEQLTRDLAGLRQFFKQLPSPPFLPAAGTADCR

Target ORF information:

RefSeq Version	NM_005195.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CCAAT enhancer binding protein delta (CEBPD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005195.3

ORF Insert Sequence:

ATGAGCGCCG CGCTCTTCAG CCTGGACGGC CCGGCGCGCG GCGCGCCCTG GCCTGCGGAG 
CCTGCGCCCT TCTACGAACC GGGCCGGGCG GGCAAGCCGG GCCGCGGGGC CGAGCCAGGG 
GCCCTAGGCG AGCCAGGCGC CGCCGCCCCC GCCATGTACG ACGACGAGAG CGCCATCGAC 
TTCAGCGCCT ACATCGACTC CATGGCCGCC GTGCCCACCC TGGAGCTGTG CCACGACGAG 
CTCTTCGCCG ACCTCTTCAA CAGCAATCAC AAGGCGGGCG GCGCGGGGCC CCTGGAGCTT 
CTTCCCGGCG GCCCCGCGCG CCCCTTGGGC CCGGGCCCTG CCGCTCCCCG CCTGCTCAAG 
CGCGAGCCCG ACTGGGGCGA CGGCGACGCG CCCGGCTCGC TGTTGCCCGC GCAGGTGGCC 
GCGTGCGCAC AGACCGTGGT GAGCTTGGCG GCCGCAGGGC AGCCCACCCC GCCCACGTCG 
CCGGAGCCGC CGCGCAGCAG CCCCAGGCAG ACCCCCGCGC CCGGCCCCGC CCGGGAGAAG 
AGCGCCGGCA AGAGGGGCCC GGACCGCGGC AGCCCCGAGT ACCGGCAGCG GCGCGAGCGC 
AACAACATCG CCGTGCGCAA GAGCCGCGAC AAGGCCAAGC GGCGCAACCA GGAGATGCAG 
CAGAAGTTGG TGGAGCTGTC GGCTGAGAAC GAGAAGCTGC ACCAGCGCGT GGAGCAGCTC 
ACGCGGGACC TGGCCGGCCT CCGGCAGTTC TTCAAGCAGC TGCCCAGCCC GCCCTTCCTG 
CCGGCCGCCG GGACAGCAGA CTGCCGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CEBPD ( NM_005195.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005186.2 Homo sapiens CCAAT enhancer binding protein delta (CEBPD), mRNA.

Price & Availability↑

CloneID	OHu17203
Clone ID Related Accession (Same CDS sequence)	NM_005195.3 , NM_005195.4
Accession Version	NM_005195.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577721600000
Organism	Homo sapiens(human)
Product	CCAAT/enhancer-binding protein delta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M83667.1, BC105109.1, BQ773696.1 and AC023991.9. On May 17, 2019 this sequence version replaced NM_005195.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: ERR279841.786.1, ERR279834.2094.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000408965.4/ ENSP00000386165.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCGCCG CGCTCTTCAG CCTGGACGGC CCGGCGCGCG GCGCGCCCTG GCCTGCGGAG 
CCTGCGCCCT TCTACGAACC GGGCCGGGCG GGCAAGCCGG GCCGCGGGGC CGAGCCAGGG 
GCCCTAGGCG AGCCAGGCGC CGCCGCCCCC GCCATGTACG ACGACGAGAG CGCCATCGAC 
TTCAGCGCCT ACATCGACTC CATGGCCGCC GTGCCCACCC TGGAGCTGTG CCACGACGAG 
CTCTTCGCCG ACCTCTTCAA CAGCAATCAC AAGGCGGGCG GCGCGGGGCC CCTGGAGCTT 
CTTCCCGGCG GCCCCGCGCG CCCCTTGGGC CCGGGCCCTG CCGCTCCCCG CCTGCTCAAG 
CGCGAGCCCG ACTGGGGCGA CGGCGACGCG CCCGGCTCGC TGTTGCCCGC GCAGGTGGCC 
GCGTGCGCAC AGACCGTGGT GAGCTTGGCG GCCGCAGGGC AGCCCACCCC GCCCACGTCG 
CCGGAGCCGC CGCGCAGCAG CCCCAGGCAG ACCCCCGCGC CCGGCCCCGC CCGGGAGAAG 
AGCGCCGGCA AGAGGGGCCC GGACCGCGGC AGCCCCGAGT ACCGGCAGCG GCGCGAGCGC 
AACAACATCG CCGTGCGCAA GAGCCGCGAC AAGGCCAAGC GGCGCAACCA GGAGATGCAG 
CAGAAGTTGG TGGAGCTGTC GGCTGAGAAC GAGAAGCTGC ACCAGCGCGT GGAGCAGCTC 
ACGCGGGACC TGGCCGGCCT CCGGCAGTTC TTCAAGCAGC TGCCCAGCCC GCCCTTCCTG 
CCGGCCGCCG GGACAGCAGA CTGCCGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005186.2
CDS	45..854
Translation	MSAALFSLDGPARGAPWPAEPAPFYEPGRAGKPGRGAEPGALGEPGAAAPAMYDDESAIDFSAYIDSMAAVPTLELCHDELFADLFNSNHKAGGAGPLELLPGGPARPLGPGPAAPRLLKREPDWGDGDAPGSLLPAQVAACAQTVVSLAAAGQPTPPTSPEPPRSSPRQTPAPGPAREKSAGKRGPDRGSPEYRQRRERNNIAVRKSRDKAKRRNQEMQQKLVELSAENEKLHQRVEQLTRDLAGLRQFFKQLPSPPFLPAAGTADCR

Target ORF information:

RefSeq Version	NM_005195.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CCAAT enhancer binding protein delta (CEBPD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005195.4

ORF Insert Sequence:

ATGAGCGCCG CGCTCTTCAG CCTGGACGGC CCGGCGCGCG GCGCGCCCTG GCCTGCGGAG 
CCTGCGCCCT TCTACGAACC GGGCCGGGCG GGCAAGCCGG GCCGCGGGGC CGAGCCAGGG 
GCCCTAGGCG AGCCAGGCGC CGCCGCCCCC GCCATGTACG ACGACGAGAG CGCCATCGAC 
TTCAGCGCCT ACATCGACTC CATGGCCGCC GTGCCCACCC TGGAGCTGTG CCACGACGAG 
CTCTTCGCCG ACCTCTTCAA CAGCAATCAC AAGGCGGGCG GCGCGGGGCC CCTGGAGCTT 
CTTCCCGGCG GCCCCGCGCG CCCCTTGGGC CCGGGCCCTG CCGCTCCCCG CCTGCTCAAG 
CGCGAGCCCG ACTGGGGCGA CGGCGACGCG CCCGGCTCGC TGTTGCCCGC GCAGGTGGCC 
GCGTGCGCAC AGACCGTGGT GAGCTTGGCG GCCGCAGGGC AGCCCACCCC GCCCACGTCG 
CCGGAGCCGC CGCGCAGCAG CCCCAGGCAG ACCCCCGCGC CCGGCCCCGC CCGGGAGAAG 
AGCGCCGGCA AGAGGGGCCC GGACCGCGGC AGCCCCGAGT ACCGGCAGCG GCGCGAGCGC 
AACAACATCG CCGTGCGCAA GAGCCGCGAC AAGGCCAAGC GGCGCAACCA GGAGATGCAG 
CAGAAGTTGG TGGAGCTGTC GGCTGAGAAC GAGAAGCTGC ACCAGCGCGT GGAGCAGCTC 
ACGCGGGACC TGGCCGGCCT CCGGCAGTTC TTCAAGCAGC TGCCCAGCCC GCCCTTCCTG 
CCGGCCGCCG GGACAGCAGA CTGCCGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CCAAT/enhancer binding protein delta (C/EBPδ) demonstrates a dichotomous role in tumour initiation and promotion of epithelial carcinoma.
EBioMedicine44261-274(2019 Jun)
Sowamber R,Chehade R,Bitar M,Dodds LV,Milea A,Slomovitz B,Shaw PA,George SHL

C/EBPδ links IL-6 and HIF-1 signaling to promote breast cancer stem cell-associated phenotypes.
Oncogene38(20)3765-3780(2019 05)
Balamurugan K,Mendoza-Villanueva D,Sharan S,Summers GH,Dobrolecki LE,Lewis MT,Sterneck E

Action and clinical significance of CCAAT/enhancer-binding protein delta in hepatocellular carcinoma.
Carcinogenesis40(1)155-163(2019 03)
Liu P,Cao W,Ma B,Li M,Chen K,Sideras K,Duitman JW,Sprengers D,Khe Tran TC,Ijzermans JNM,Biermann K,Verheij J,Spek CA,Kwekkeboom J,Pan Q,Peppelenbosch MP

Gemcabene, a first-in-class lipid-lowering agent in late-stage development, down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism.
Molecular and cellular biochemistry449(1-2)167-183(2018 Dec)
Srivastava RAK,Cornicelli JA,Markham B,Bisgaier CL

C/EBPδ drives interactions between human MAIT cells and endothelial cells that are important for extravasation.
eLife7(2018 02)
Lee CH,Zhang HH,Singh SP,Koo L,Kabat J,Tsang H,Singh TP,Farber JM

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CEBPD cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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