CDK2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDK2
Entrez Gene ID	1017
Full Name	cyclin dependent kinase 2
Synonyms	CDKN2,p33(CDK2)
General protein information	Preferred Names cyclin dependent kinase 2 Names cyclin-dependent kinase 2 cdc2-related protein kinase cell division protein kinase 2 p33 protein kinase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.2
Summary	This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
Disorder MIM:	116953

mRNA and Protein(s)

mRNA	Protein	Name
NM_001798.5	NP_001789.2	cyclin-dependent kinase 2 isoform 1
XM_011537732.2	XP_011536034.1	cyclin-dependent kinase 2 isoform X1
NM_001290230.1	NP_001277159.1	cyclin-dependent kinase 2 isoform 3
NM_052827.4	NP_439892.2	cyclin-dependent kinase 2 isoform 2
XM_011537732.1	XP_011536034.1	cyclin-dependent kinase 2 isoform X1
NM_001290230.2	NP_001277159.1	cyclin-dependent kinase 2 isoform 3
NM_001798.4	NP_001789.2	cyclin-dependent kinase 2 isoform 1
NM_052827.3	NP_439892.2	cyclin-dependent kinase 2 isoform 2

Pathways from BioSystems

Homologies

Neurospora crassa	NCU09778	XP_960117.1
Pan troglodytes (chimpanzee)	CDK2	XP_003952210.1
Oryza sativa (rice)	Os03g0118400	NP_001048772.1
Saccharomyces cerevisiae (baker's yeast)	CDC28	NP_009718.3
Schizosaccharomyces pombe (fission yeast)	cdc2	NP_595629.1
Eremothecium gossypii	AGOS_ADR058C	NP_984154.1
Kluyveromyces lactis	KLLA0B09790g	XP_451964.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004579	XP_562342.4
Bos taurus (cattle)	CDK2	NP_001014934.1
Mus musculus (house mouse)	Cdk2	NP_904326.1
Rattus norvegicus (Norway rat)	Cdk2	NP_955795.1
Drosophila melanogaster (fruit fly)	cdc2c	NP_732544.1
Arabidopsis thaliana (thale cress)	CDC2	NP_566911.1
Xenopus tropicalis (tropical clawed frog)	cdk2	NP_001008136.1
Magnaporthe oryzae (rice blast fungus)	MGG_01362	XP_003714294.1
Homo sapiens (human)	CDK2	NP_001789.2
Macaca mulatta (Rhesus monkey)	CDK2	XP_001113345.1
Canis lupus familiaris (dog)	CDK2	XP_005625536.1
Gallus gallus (chicken)	CDK2	NP_001186786.1
Oryza sativa (rice)	Os02g0123100	NP_001045731.1
Danio rerio (zebrafish)	cdk2	NP_998571.1

Gene Ontology
Bibliography

Related articles in PubMed

Amplification of SMYD3 promotes tumorigenicity and intrahepatic metastasis of hepatocellular carcinoma via upregulation of CDK2 and MMP2.
Wang Y, Xie BH, Lin WH, Huang YH, Ni JY, Hu J, Cui W, Zhou J, Shen L, Xu LF, Lian F, Li HP
Oncogene38(25)4948-4961(2019 06)

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Hubel P, Urban C, Bergant V, Schneider WM, Knauer B, Stukalov A, Scaturro P, Mann A, Brunotte L, Hoffmann HH, Schoggins JW, Schwemmle M, Mann M, Rice CM, Pichlmair A
Nature immunology20(4)493-502(2019 04)

Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe.
Warren NJH, Eastman A
The Journal of biological chemistry294(6)1763-1778(2019 02)

Function of the amino-terminal region of human MCM4 in helicase activity.
Wang X, Ishimi Y
Journal of biochemistry164(6)449-460(2018 Dec)

A type 2 diabetes disease module with a high collective influence for Cdk2 and PTPLAD1 is localized in endosomes.
Boutchueng-Djidjou M, Belleau P, Bilodeau N, Fortier S, Bourassa S, Droit A, Elowe S, Faure RL
PloS one13(10)e0205180(2018)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CDK2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDK2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23351	NM_001798.5 Latest version!	Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu23770	NM_052827.4 Latest version!	Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu23867	NM_001290230.2 Latest version!	Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu56793	XM_011537732.2 Latest version!	Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu56793	XM_011537732.1	Homo sapiens cyclin-dependent kinase 2 (CDK2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu23867	NM_001290230.1	Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu23351	NM_001798.4	Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu23770	NM_052827.3	Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDK2 ( NM_001798.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001789.2 Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23351
Clone ID Related Accession (Same CDS sequence)	NM_001798.5 , NM_001798.4
Accession Version	NM_001798.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA814453.1, AK291941.1, BC003065.2 and AA789250.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001798.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.367753.1, SRR1163658.467306.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000266970.9/ ENSP00000266970.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 
GCCAGAAACA AGTTGACGGG AGAGGTGGTG GCGCTTAAGA AAATCCGCCT GGACACTGAG 
ACTGAGGGTG TGCCCAGTAC TGCCATCCGA GAGATCTCTC TGCTTAAGGA GCTTAACCAT 
CCTAATATTG TCAAGCTGCT GGATGTCATT CACACAGAAA ATAAACTCTA CCTGGTTTTT 
GAATTTCTGC ACCAAGATCT CAAGAAATTC ATGGATGCCT CTGCTCTCAC TGGCATTCCT 
CTTCCCCTCA TCAAGAGCTA TCTGTTCCAG CTGCTCCAGG GCCTAGCTTT CTGCCATTCT 
CATCGGGTCC TCCACCGAGA CCTTAAACCT CAGAATCTGC TTATTAACAC AGAGGGGGCC 
ATCAAGCTAG CAGACTTTGG ACTAGCCAGA GCTTTTGGAG TCCCTGTTCG TACTTACACC 
CATGAGGTGG TGACCCTGTG GTACCGAGCT CCTGAAATCC TCCTGGGCTG CAAATATTAT 
TCCACAGCTG TGGACATCTG GAGCCTGGGC TGCATCTTTG CTGAGATGGT GACTCGCCGG 
GCCCTATTCC CTGGAGATTC TGAGATTGAC CAGCTCTTCC GGATCTTTCG GACTCTGGGG 
ACCCCAGATG AGGTGGTGTG GCCAGGAGTT ACTTCTATGC CTGATTACAA GCCAAGTTTC 
CCCAAGTGGG CCCGGCAAGA TTTTAGTAAA GTTGTACCTC CCCTGGATGA AGATGGACGG 
AGCTTGTTAT CGCAAATGCT GCACTACGAC CCTAACAAGC GGATTTCGGC CAAGGCAGCC 
CTGGCTCACC CTTTCTTCCA GGATGTGACC AAGCCAGTAC CCCATCTTCG ACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001789.2
CDS	180..1076
Translation	MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

Target ORF information:

RefSeq Version	NM_001798.5
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001798.5

ORF Insert Sequence:

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 
GCCAGAAACA AGTTGACGGG AGAGGTGGTG GCGCTTAAGA AAATCCGCCT GGACACTGAG 
ACTGAGGGTG TGCCCAGTAC TGCCATCCGA GAGATCTCTC TGCTTAAGGA GCTTAACCAT 
CCTAATATTG TCAAGCTGCT GGATGTCATT CACACAGAAA ATAAACTCTA CCTGGTTTTT 
GAATTTCTGC ACCAAGATCT CAAGAAATTC ATGGATGCCT CTGCTCTCAC TGGCATTCCT 
CTTCCCCTCA TCAAGAGCTA TCTGTTCCAG CTGCTCCAGG GCCTAGCTTT CTGCCATTCT 
CATCGGGTCC TCCACCGAGA CCTTAAACCT CAGAATCTGC TTATTAACAC AGAGGGGGCC 
ATCAAGCTAG CAGACTTTGG ACTAGCCAGA GCTTTTGGAG TCCCTGTTCG TACTTACACC 
CATGAGGTGG TGACCCTGTG GTACCGAGCT CCTGAAATCC TCCTGGGCTG CAAATATTAT 
TCCACAGCTG TGGACATCTG GAGCCTGGGC TGCATCTTTG CTGAGATGGT GACTCGCCGG 
GCCCTATTCC CTGGAGATTC TGAGATTGAC CAGCTCTTCC GGATCTTTCG GACTCTGGGG 
ACCCCAGATG AGGTGGTGTG GCCAGGAGTT ACTTCTATGC CTGATTACAA GCCAAGTTTC 
CCCAAGTGGG CCCGGCAAGA TTTTAGTAAA GTTGTACCTC CCCTGGATGA AGATGGACGG 
AGCTTGTTAT CGCAAATGCT GCACTACGAC CCTAACAAGC GGATTTCGGC CAAGGCAGCC 
CTGGCTCACC CTTTCTTCCA GGATGTGACC AAGCCAGTAC CCCATCTTCG ACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK2 ( NM_001798.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001789.2 Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23351
Clone ID Related Accession (Same CDS sequence)	NM_001798.5 , NM_001798.4
Accession Version	NM_001798.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514649600000
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA814453.1, AK291941.1, BC003065.2 and AA789250.1. This sequence is a reference standard in the RefSeqGene project. On Mar 4, 2014 this sequence version replaced NM_001798.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.495152.1, SRR1163658.77683.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 
GCCAGAAACA AGTTGACGGG AGAGGTGGTG GCGCTTAAGA AAATCCGCCT GGACACTGAG 
ACTGAGGGTG TGCCCAGTAC TGCCATCCGA GAGATCTCTC TGCTTAAGGA GCTTAACCAT 
CCTAATATTG TCAAGCTGCT GGATGTCATT CACACAGAAA ATAAACTCTA CCTGGTTTTT 
GAATTTCTGC ACCAAGATCT CAAGAAATTC ATGGATGCCT CTGCTCTCAC TGGCATTCCT 
CTTCCCCTCA TCAAGAGCTA TCTGTTCCAG CTGCTCCAGG GCCTAGCTTT CTGCCATTCT 
CATCGGGTCC TCCACCGAGA CCTTAAACCT CAGAATCTGC TTATTAACAC AGAGGGGGCC 
ATCAAGCTAG CAGACTTTGG ACTAGCCAGA GCTTTTGGAG TCCCTGTTCG TACTTACACC 
CATGAGGTGG TGACCCTGTG GTACCGAGCT CCTGAAATCC TCCTGGGCTG CAAATATTAT 
TCCACAGCTG TGGACATCTG GAGCCTGGGC TGCATCTTTG CTGAGATGGT GACTCGCCGG 
GCCCTATTCC CTGGAGATTC TGAGATTGAC CAGCTCTTCC GGATCTTTCG GACTCTGGGG 
ACCCCAGATG AGGTGGTGTG GCCAGGAGTT ACTTCTATGC CTGATTACAA GCCAAGTTTC 
CCCAAGTGGG CCCGGCAAGA TTTTAGTAAA GTTGTACCTC CCCTGGATGA AGATGGACGG 
AGCTTGTTAT CGCAAATGCT GCACTACGAC CCTAACAAGC GGATTTCGGC CAAGGCAGCC 
CTGGCTCACC CTTTCTTCCA GGATGTGACC AAGCCAGTAC CCCATCTTCG ACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001789.2
CDS	241..1137
Translation	MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

Target ORF information:

RefSeq Version	NM_001798.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001798.4

ORF Insert Sequence:

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 
GCCAGAAACA AGTTGACGGG AGAGGTGGTG GCGCTTAAGA AAATCCGCCT GGACACTGAG 
ACTGAGGGTG TGCCCAGTAC TGCCATCCGA GAGATCTCTC TGCTTAAGGA GCTTAACCAT 
CCTAATATTG TCAAGCTGCT GGATGTCATT CACACAGAAA ATAAACTCTA CCTGGTTTTT 
GAATTTCTGC ACCAAGATCT CAAGAAATTC ATGGATGCCT CTGCTCTCAC TGGCATTCCT 
CTTCCCCTCA TCAAGAGCTA TCTGTTCCAG CTGCTCCAGG GCCTAGCTTT CTGCCATTCT 
CATCGGGTCC TCCACCGAGA CCTTAAACCT CAGAATCTGC TTATTAACAC AGAGGGGGCC 
ATCAAGCTAG CAGACTTTGG ACTAGCCAGA GCTTTTGGAG TCCCTGTTCG TACTTACACC 
CATGAGGTGG TGACCCTGTG GTACCGAGCT CCTGAAATCC TCCTGGGCTG CAAATATTAT 
TCCACAGCTG TGGACATCTG GAGCCTGGGC TGCATCTTTG CTGAGATGGT GACTCGCCGG 
GCCCTATTCC CTGGAGATTC TGAGATTGAC CAGCTCTTCC GGATCTTTCG GACTCTGGGG 
ACCCCAGATG AGGTGGTGTG GCCAGGAGTT ACTTCTATGC CTGATTACAA GCCAAGTTTC 
CCCAAGTGGG CCCGGCAAGA TTTTAGTAAA GTTGTACCTC CCCTGGATGA AGATGGACGG 
AGCTTGTTAT CGCAAATGCT GCACTACGAC CCTAACAAGC GGATTTCGGC CAAGGCAGCC 
CTGGCTCACC CTTTCTTCCA GGATGTGACC AAGCCAGTAC CCCATCTTCG ACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK2 ( NM_052827.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_439892.2 Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23770
Clone ID Related Accession (Same CDS sequence)	NM_052827.4 , NM_052827.3
Accession Version	NM_052827.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577721600000
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA814453.1, AB012305.1, BC003065.2 and AA789250.1. On May 31, 2019 this sequence version replaced NM_052827.3. Transcript Variant: This variant (2, also known as CDK2deltaT) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2, also known as d-HSCDK2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.113942.1, SRR1803615.169026.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 
GCCAGAAACA AGTTGACGGG AGAGGTGGTG GCGCTTAAGA AAATCCGCCT GGACACTGAG 
ACTGAGGGTG TGCCCAGTAC TGCCATCCGA GAGATCTCTC TGCTTAAGGA GCTTAACCAT 
CCTAATATTG TCAAGCTGCT GGATGTCATT CACACAGAAA ATAAACTCTA CCTGGTTTTT 
GAATTTCTGC ACCAAGATCT CAAGAAATTC ATGGATGCCT CTGCTCTCAC TGGCATTCCT 
CTTCCCCTCA TCAAGAGCTA TCTGTTCCAG CTGCTCCAGG GCCTAGCTTT CTGCCATTCT 
CATCGGGTCC TCCACCGAGA CCTTAAACCT CAGAATCTGC TTATTAACAC AGAGGGGGCC 
ATCAAGCTAG CAGACTTTGG ACTAGCCAGA GCTTTTGGAG TCCCTGTTCG TACTTACACC 
CATGAGGTGA CTCGCCGGGC CCTATTCCCT GGAGATTCTG AGATTGACCA GCTCTTCCGG 
ATCTTTCGGA CTCTGGGGAC CCCAGATGAG GTGGTGTGGC CAGGAGTTAC TTCTATGCCT 
GATTACAAGC CAAGTTTCCC CAAGTGGGCC CGGCAAGATT TTAGTAAAGT TGTACCTCCC 
CTGGATGAAG ATGGACGGAG CTTGTTATCG CAAATGCTGC ACTACGACCC TAACAAGCGG 
ATTTCGGCCA AGGCAGCCCT GGCTCACCCT TTCTTCCAGG ATGTGACCAA GCCAGTACCC 
CATCTTCGAC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_439892.2
CDS	180..974
Translation	MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

Target ORF information:

RefSeq Version	NM_052827.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052827.4

ORF Insert Sequence:

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 
GCCAGAAACA AGTTGACGGG AGAGGTGGTG GCGCTTAAGA AAATCCGCCT GGACACTGAG 
ACTGAGGGTG TGCCCAGTAC TGCCATCCGA GAGATCTCTC TGCTTAAGGA GCTTAACCAT 
CCTAATATTG TCAAGCTGCT GGATGTCATT CACACAGAAA ATAAACTCTA CCTGGTTTTT 
GAATTTCTGC ACCAAGATCT CAAGAAATTC ATGGATGCCT CTGCTCTCAC TGGCATTCCT 
CTTCCCCTCA TCAAGAGCTA TCTGTTCCAG CTGCTCCAGG GCCTAGCTTT CTGCCATTCT 
CATCGGGTCC TCCACCGAGA CCTTAAACCT CAGAATCTGC TTATTAACAC AGAGGGGGCC 
ATCAAGCTAG CAGACTTTGG ACTAGCCAGA GCTTTTGGAG TCCCTGTTCG TACTTACACC 
CATGAGGTGA CTCGCCGGGC CCTATTCCCT GGAGATTCTG AGATTGACCA GCTCTTCCGG 
ATCTTTCGGA CTCTGGGGAC CCCAGATGAG GTGGTGTGGC CAGGAGTTAC TTCTATGCCT 
GATTACAAGC CAAGTTTCCC CAAGTGGGCC CGGCAAGATT TTAGTAAAGT TGTACCTCCC 
CTGGATGAAG ATGGACGGAG CTTGTTATCG CAAATGCTGC ACTACGACCC TAACAAGCGG 
ATTTCGGCCA AGGCAGCCCT GGCTCACCCT TTCTTCCAGG ATGTGACCAA GCCAGTACCC 
CATCTTCGAC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK2 ( NM_052827.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_439892.2 Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23770
Clone ID Related Accession (Same CDS sequence)	NM_052827.4 , NM_052827.3
Accession Version	NM_052827.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1547222400000
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA814453.1, AB012305.1, BC003065.2 and AA789250.1. On Mar 4, 2014 this sequence version replaced NM_052827.2. Transcript Variant: This variant (2, also known as CDK2deltaT) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2, also known as d-HSCDK2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.16170.1, SRR1163655.191370.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 
GCCAGAAACA AGTTGACGGG AGAGGTGGTG GCGCTTAAGA AAATCCGCCT GGACACTGAG 
ACTGAGGGTG TGCCCAGTAC TGCCATCCGA GAGATCTCTC TGCTTAAGGA GCTTAACCAT 
CCTAATATTG TCAAGCTGCT GGATGTCATT CACACAGAAA ATAAACTCTA CCTGGTTTTT 
GAATTTCTGC ACCAAGATCT CAAGAAATTC ATGGATGCCT CTGCTCTCAC TGGCATTCCT 
CTTCCCCTCA TCAAGAGCTA TCTGTTCCAG CTGCTCCAGG GCCTAGCTTT CTGCCATTCT 
CATCGGGTCC TCCACCGAGA CCTTAAACCT CAGAATCTGC TTATTAACAC AGAGGGGGCC 
ATCAAGCTAG CAGACTTTGG ACTAGCCAGA GCTTTTGGAG TCCCTGTTCG TACTTACACC 
CATGAGGTGA CTCGCCGGGC CCTATTCCCT GGAGATTCTG AGATTGACCA GCTCTTCCGG 
ATCTTTCGGA CTCTGGGGAC CCCAGATGAG GTGGTGTGGC CAGGAGTTAC TTCTATGCCT 
GATTACAAGC CAAGTTTCCC CAAGTGGGCC CGGCAAGATT TTAGTAAAGT TGTACCTCCC 
CTGGATGAAG ATGGACGGAG CTTGTTATCG CAAATGCTGC ACTACGACCC TAACAAGCGG 
ATTTCGGCCA AGGCAGCCCT GGCTCACCCT TTCTTCCAGG ATGTGACCAA GCCAGTACCC 
CATCTTCGAC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_439892.2
CDS	241..1035
Translation	MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

Target ORF information:

RefSeq Version	NM_052827.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052827.3

ORF Insert Sequence:

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 
GCCAGAAACA AGTTGACGGG AGAGGTGGTG GCGCTTAAGA AAATCCGCCT GGACACTGAG 
ACTGAGGGTG TGCCCAGTAC TGCCATCCGA GAGATCTCTC TGCTTAAGGA GCTTAACCAT 
CCTAATATTG TCAAGCTGCT GGATGTCATT CACACAGAAA ATAAACTCTA CCTGGTTTTT 
GAATTTCTGC ACCAAGATCT CAAGAAATTC ATGGATGCCT CTGCTCTCAC TGGCATTCCT 
CTTCCCCTCA TCAAGAGCTA TCTGTTCCAG CTGCTCCAGG GCCTAGCTTT CTGCCATTCT 
CATCGGGTCC TCCACCGAGA CCTTAAACCT CAGAATCTGC TTATTAACAC AGAGGGGGCC 
ATCAAGCTAG CAGACTTTGG ACTAGCCAGA GCTTTTGGAG TCCCTGTTCG TACTTACACC 
CATGAGGTGA CTCGCCGGGC CCTATTCCCT GGAGATTCTG AGATTGACCA GCTCTTCCGG 
ATCTTTCGGA CTCTGGGGAC CCCAGATGAG GTGGTGTGGC CAGGAGTTAC TTCTATGCCT 
GATTACAAGC CAAGTTTCCC CAAGTGGGCC CGGCAAGATT TTAGTAAAGT TGTACCTCCC 
CTGGATGAAG ATGGACGGAG CTTGTTATCG CAAATGCTGC ACTACGACCC TAACAAGCGG 
ATTTCGGCCA AGGCAGCCCT GGCTCACCCT TTCTTCCAGG ATGTGACCAA GCCAGTACCC 
CATCTTCGAC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK2 ( NM_001290230.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001277159.1 Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 3, mRNA.

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CloneID	OHu23867
Clone ID Related Accession (Same CDS sequence)	NM_001290230.1 , NM_001290230.2
Accession Version	NM_001290230.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1547222400000
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 2 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA814453.1, AK293246.1, BC003065.2 and AA789250.1. Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK293246.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 
GCCAGAAACA AGTTGACGGG AGAGGTGGTG GCGCTTAAGA AAATCCGCCT GGACACGCTG 
CTGGATGTCA TTCACACAGA AAATAAACTC TACCTGGTTT TTGAATTTCT GCACCAAGAT 
CTCAAGAAAT TCATGGATGC CTCTGCTCTC ACTGGCATTC CTCTTCCCCT CATCAAGAGC 
TATCTGTTCC AGCTGCTCCA GGGCCTAGCT TTCTGCCATT CTCATCGGGT CCTCCACCGA 
GACCTTAAAC CTCAGAATCT GCTTATTAAC ACAGAGGGGG CCATCAAGCT AGCAGACTTT 
GGACTAGCCA GAGCTTTTGG AGTCCCTGTT CGTACTTACA CCCATGAGGT GACTCGCCGG 
GCCCTATTCC CTGGAGATTC TGAGATTGAC CAGCTCTTCC GGATCTTTCG GACTCTGGGG 
ACCCCAGATG AGGTGGTGTG GCCAGGAGTT ACTTCTATGC CTGATTACAA GCCAAGTTTC 
CCCAAGTGGG CCCGGCAAGA TTTTAGTAAA GTTGTACCTC CCCTGGATGA AGATGGACGG 
AGCTTGTTAT CGCAAATGCT GCACTACGAC CCTAACAAGC GGATTTCGGC CAAGGCAGCC 
CTGGCTCACC CTTTCTTCCA GGATGTGACC AAGCCAGTAC CCCATCTTCG ACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001277159.1
CDS	241..957
Translation	MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

Target ORF information:

RefSeq Version	NM_001290230.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001290230.1

ORF Insert Sequence:

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 
GCCAGAAACA AGTTGACGGG AGAGGTGGTG GCGCTTAAGA AAATCCGCCT GGACACGCTG 
CTGGATGTCA TTCACACAGA AAATAAACTC TACCTGGTTT TTGAATTTCT GCACCAAGAT 
CTCAAGAAAT TCATGGATGC CTCTGCTCTC ACTGGCATTC CTCTTCCCCT CATCAAGAGC 
TATCTGTTCC AGCTGCTCCA GGGCCTAGCT TTCTGCCATT CTCATCGGGT CCTCCACCGA 
GACCTTAAAC CTCAGAATCT GCTTATTAAC ACAGAGGGGG CCATCAAGCT AGCAGACTTT 
GGACTAGCCA GAGCTTTTGG AGTCCCTGTT CGTACTTACA CCCATGAGGT GACTCGCCGG 
GCCCTATTCC CTGGAGATTC TGAGATTGAC CAGCTCTTCC GGATCTTTCG GACTCTGGGG 
ACCCCAGATG AGGTGGTGTG GCCAGGAGTT ACTTCTATGC CTGATTACAA GCCAAGTTTC 
CCCAAGTGGG CCCGGCAAGA TTTTAGTAAA GTTGTACCTC CCCTGGATGA AGATGGACGG 
AGCTTGTTAT CGCAAATGCT GCACTACGAC CCTAACAAGC GGATTTCGGC CAAGGCAGCC 
CTGGCTCACC CTTTCTTCCA GGATGTGACC AAGCCAGTAC CCCATCTTCG ACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK2 ( NM_001290230.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001277159.1 Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 3, mRNA.

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CloneID	OHu23867
Clone ID Related Accession (Same CDS sequence)	NM_001290230.1 , NM_001290230.2
Accession Version	NM_001290230.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577980800000
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 2 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA814453.1, AK293246.1, BC003065.2 and AA789250.1. On May 31, 2019 this sequence version replaced NM_001290230.1. Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK293246.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 
GCCAGAAACA AGTTGACGGG AGAGGTGGTG GCGCTTAAGA AAATCCGCCT GGACACGCTG 
CTGGATGTCA TTCACACAGA AAATAAACTC TACCTGGTTT TTGAATTTCT GCACCAAGAT 
CTCAAGAAAT TCATGGATGC CTCTGCTCTC ACTGGCATTC CTCTTCCCCT CATCAAGAGC 
TATCTGTTCC AGCTGCTCCA GGGCCTAGCT TTCTGCCATT CTCATCGGGT CCTCCACCGA 
GACCTTAAAC CTCAGAATCT GCTTATTAAC ACAGAGGGGG CCATCAAGCT AGCAGACTTT 
GGACTAGCCA GAGCTTTTGG AGTCCCTGTT CGTACTTACA CCCATGAGGT GACTCGCCGG 
GCCCTATTCC CTGGAGATTC TGAGATTGAC CAGCTCTTCC GGATCTTTCG GACTCTGGGG 
ACCCCAGATG AGGTGGTGTG GCCAGGAGTT ACTTCTATGC CTGATTACAA GCCAAGTTTC 
CCCAAGTGGG CCCGGCAAGA TTTTAGTAAA GTTGTACCTC CCCTGGATGA AGATGGACGG 
AGCTTGTTAT CGCAAATGCT GCACTACGAC CCTAACAAGC GGATTTCGGC CAAGGCAGCC 
CTGGCTCACC CTTTCTTCCA GGATGTGACC AAGCCAGTAC CCCATCTTCG ACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001277159.1
CDS	180..896
Translation	MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

Target ORF information:

RefSeq Version	NM_001290230.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001290230.2

ORF Insert Sequence:

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 
GCCAGAAACA AGTTGACGGG AGAGGTGGTG GCGCTTAAGA AAATCCGCCT GGACACGCTG 
CTGGATGTCA TTCACACAGA AAATAAACTC TACCTGGTTT TTGAATTTCT GCACCAAGAT 
CTCAAGAAAT TCATGGATGC CTCTGCTCTC ACTGGCATTC CTCTTCCCCT CATCAAGAGC 
TATCTGTTCC AGCTGCTCCA GGGCCTAGCT TTCTGCCATT CTCATCGGGT CCTCCACCGA 
GACCTTAAAC CTCAGAATCT GCTTATTAAC ACAGAGGGGG CCATCAAGCT AGCAGACTTT 
GGACTAGCCA GAGCTTTTGG AGTCCCTGTT CGTACTTACA CCCATGAGGT GACTCGCCGG 
GCCCTATTCC CTGGAGATTC TGAGATTGAC CAGCTCTTCC GGATCTTTCG GACTCTGGGG 
ACCCCAGATG AGGTGGTGTG GCCAGGAGTT ACTTCTATGC CTGATTACAA GCCAAGTTTC 
CCCAAGTGGG CCCGGCAAGA TTTTAGTAAA GTTGTACCTC CCCTGGATGA AGATGGACGG 
AGCTTGTTAT CGCAAATGCT GCACTACGAC CCTAACAAGC GGATTTCGGC CAAGGCAGCC 
CTGGCTCACC CTTTCTTCCA GGATGTGACC AAGCCAGTAC CCCATCTTCG ACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK2 ( XM_011537732.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011536034.1 Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu56793
Clone ID Related Accession (Same CDS sequence)	XM_011537732.2 , XM_011537732.1
Accession Version	XM_011537732.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011537732.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 
GCCAGAAACA AGTTGACGGG AGAGGTGGTG GCGCTTAAGA AAATCCGCCT GGACACTGAG 
ACTGAGGGTG TGCCCAGTAC TGCCATCCGA GAGATCTCTC TGCTTAAGGA GCTTAACCAT 
CCTAATATTG TCAAGCTGCT GGATGTCATT CACACAGAAA ATAAACTCTA CCTGGTTTTT 
GAATTTCTGC ACCAAGATCT CAAGAAATTC ATGGATGCCT CTGCTCTCAC TGGCATTCCT 
CTTCCCCTCA TCAAGAGCTA TCTGTTCCAG CTGCTCCAGG GCCTAGCTTT CTGCCATTCT 
CATCGGGTCC TCCACCGAGA CCTTAAACCT CAGAATCTGC TTATTAACAC AGAGGGGGCC 
ATCAAGCTAG CAGACTTTGG ACTAGCCAGA GCTTTTGGAG TCCCTGTTCG TACTTACACC 
CATGAGGTGG TGACCCTGTG GTACCGAGCT CCTGAAATCC TCCTGGGCTG CAAATATTAT 
TCCACAGCTG TGGACATCTG GAGCCTGGGC TGCATCTTTG CTGAGATGCA CCTAGTGGGT 
ACCCAGCACC ATGCTAGGTG CTGTGGGGAA CACAGAAGAA ATGGAAGACA GAGTCTCTGC 
CCGCTGTGCT CGTATCTAGA AGTGGCTGCA TCACAAGGTT GGGGGATGAC CGCAGTGTCT 
ACCCCCTACC CCGTGACTCG CCGGGCCCTA TTCCCTGGAG ATTCTGAGAT TGACCAGCTC 
TTCCGGATCT TTCGGACTCT GGGGACCCCA GATGAGGTGG TGTGGCCAGG AGTTACTTCT 
ATGCCTGATT ACAAGCCAAG TTTCCCCAAG TGGGCCCGGC AAGATTTTAG TAAAGTTGTA 
CCTCCCCTGG ATGAAGATGG ACGGAGCTTG TTATCGCAAA TGCTGCACTA CGACCCTAAC 
AAGCGGATTT CGGCCAAGGC AGCCCTGGCT CACCCTTTCT TCCAGGATGT GACCAAGCCA 
GTACCCCATC TTCGACTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011536034.1
CDS	180..1220
Translation	MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

Target ORF information:

RefSeq Version	XM_011537732.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011537732.2

ORF Insert Sequence:

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 
GCCAGAAACA AGTTGACGGG AGAGGTGGTG GCGCTTAAGA AAATCCGCCT GGACACTGAG 
ACTGAGGGTG TGCCCAGTAC TGCCATCCGA GAGATCTCTC TGCTTAAGGA GCTTAACCAT 
CCTAATATTG TCAAGCTGCT GGATGTCATT CACACAGAAA ATAAACTCTA CCTGGTTTTT 
GAATTTCTGC ACCAAGATCT CAAGAAATTC ATGGATGCCT CTGCTCTCAC TGGCATTCCT 
CTTCCCCTCA TCAAGAGCTA TCTGTTCCAG CTGCTCCAGG GCCTAGCTTT CTGCCATTCT 
CATCGGGTCC TCCACCGAGA CCTTAAACCT CAGAATCTGC TTATTAACAC AGAGGGGGCC 
ATCAAGCTAG CAGACTTTGG ACTAGCCAGA GCTTTTGGAG TCCCTGTTCG TACTTACACC 
CATGAGGTGG TGACCCTGTG GTACCGAGCT CCTGAAATCC TCCTGGGCTG CAAATATTAT 
TCCACAGCTG TGGACATCTG GAGCCTGGGC TGCATCTTTG CTGAGATGCA CCTAGTGGGT 
ACCCAGCACC ATGCTAGGTG CTGTGGGGAA CACAGAAGAA ATGGAAGACA GAGTCTCTGC 
CCGCTGTGCT CGTATCTAGA AGTGGCTGCA TCACAAGGTT GGGGGATGAC CGCAGTGTCT 
ACCCCCTACC CCGTGACTCG CCGGGCCCTA TTCCCTGGAG ATTCTGAGAT TGACCAGCTC 
TTCCGGATCT TTCGGACTCT GGGGACCCCA GATGAGGTGG TGTGGCCAGG AGTTACTTCT 
ATGCCTGATT ACAAGCCAAG TTTCCCCAAG TGGGCCCGGC AAGATTTTAG TAAAGTTGTA 
CCTCCCCTGG ATGAAGATGG ACGGAGCTTG TTATCGCAAA TGCTGCACTA CGACCCTAAC 
AAGCGGATTT CGGCCAAGGC AGCCCTGGCT CACCCTTTCT TCCAGGATGT GACCAAGCCA 
GTACCCCATC TTCGACTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK2 ( XM_011537732.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011536034.1 Homo sapiens cyclin-dependent kinase 2 (CDK2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu56793
Clone ID Related Accession (Same CDS sequence)	XM_011537732.2 , XM_011537732.1
Accession Version	XM_011537732.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 
GCCAGAAACA AGTTGACGGG AGAGGTGGTG GCGCTTAAGA AAATCCGCCT GGACACTGAG 
ACTGAGGGTG TGCCCAGTAC TGCCATCCGA GAGATCTCTC TGCTTAAGGA GCTTAACCAT 
CCTAATATTG TCAAGCTGCT GGATGTCATT CACACAGAAA ATAAACTCTA CCTGGTTTTT 
GAATTTCTGC ACCAAGATCT CAAGAAATTC ATGGATGCCT CTGCTCTCAC TGGCATTCCT 
CTTCCCCTCA TCAAGAGCTA TCTGTTCCAG CTGCTCCAGG GCCTAGCTTT CTGCCATTCT 
CATCGGGTCC TCCACCGAGA CCTTAAACCT CAGAATCTGC TTATTAACAC AGAGGGGGCC 
ATCAAGCTAG CAGACTTTGG ACTAGCCAGA GCTTTTGGAG TCCCTGTTCG TACTTACACC 
CATGAGGTGG TGACCCTGTG GTACCGAGCT CCTGAAATCC TCCTGGGCTG CAAATATTAT 
TCCACAGCTG TGGACATCTG GAGCCTGGGC TGCATCTTTG CTGAGATGCA CCTAGTGGGT 
ACCCAGCACC ATGCTAGGTG CTGTGGGGAA CACAGAAGAA ATGGAAGACA GAGTCTCTGC 
CCGCTGTGCT CGTATCTAGA AGTGGCTGCA TCACAAGGTT GGGGGATGAC CGCAGTGTCT 
ACCCCCTACC CCGTGACTCG CCGGGCCCTA TTCCCTGGAG ATTCTGAGAT TGACCAGCTC 
TTCCGGATCT TTCGGACTCT GGGGACCCCA GATGAGGTGG TGTGGCCAGG AGTTACTTCT 
ATGCCTGATT ACAAGCCAAG TTTCCCCAAG TGGGCCCGGC AAGATTTTAG TAAAGTTGTA 
CCTCCCCTGG ATGAAGATGG ACGGAGCTTG TTATCGCAAA TGCTGCACTA CGACCCTAAC 
AAGCGGATTT CGGCCAAGGC AGCCCTGGCT CACCCTTTCT TCCAGGATGT GACCAAGCCA 
GTACCCCATC TTCGACTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011536034.1
CDS	241..1281
Translation	MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

Target ORF information:

RefSeq Version	XM_011537732.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin-dependent kinase 2 (CDK2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011537732.1

ORF Insert Sequence:

ATGGAGAACT TCCAAAAGGT GGAAAAGATC GGAGAGGGCA CGTACGGAGT TGTGTACAAA 
GCCAGAAACA AGTTGACGGG AGAGGTGGTG GCGCTTAAGA AAATCCGCCT GGACACTGAG 
ACTGAGGGTG TGCCCAGTAC TGCCATCCGA GAGATCTCTC TGCTTAAGGA GCTTAACCAT 
CCTAATATTG TCAAGCTGCT GGATGTCATT CACACAGAAA ATAAACTCTA CCTGGTTTTT 
GAATTTCTGC ACCAAGATCT CAAGAAATTC ATGGATGCCT CTGCTCTCAC TGGCATTCCT 
CTTCCCCTCA TCAAGAGCTA TCTGTTCCAG CTGCTCCAGG GCCTAGCTTT CTGCCATTCT 
CATCGGGTCC TCCACCGAGA CCTTAAACCT CAGAATCTGC TTATTAACAC AGAGGGGGCC 
ATCAAGCTAG CAGACTTTGG ACTAGCCAGA GCTTTTGGAG TCCCTGTTCG TACTTACACC 
CATGAGGTGG TGACCCTGTG GTACCGAGCT CCTGAAATCC TCCTGGGCTG CAAATATTAT 
TCCACAGCTG TGGACATCTG GAGCCTGGGC TGCATCTTTG CTGAGATGCA CCTAGTGGGT 
ACCCAGCACC ATGCTAGGTG CTGTGGGGAA CACAGAAGAA ATGGAAGACA GAGTCTCTGC 
CCGCTGTGCT CGTATCTAGA AGTGGCTGCA TCACAAGGTT GGGGGATGAC CGCAGTGTCT 
ACCCCCTACC CCGTGACTCG CCGGGCCCTA TTCCCTGGAG ATTCTGAGAT TGACCAGCTC 
TTCCGGATCT TTCGGACTCT GGGGACCCCA GATGAGGTGG TGTGGCCAGG AGTTACTTCT 
ATGCCTGATT ACAAGCCAAG TTTCCCCAAG TGGGCCCGGC AAGATTTTAG TAAAGTTGTA 
CCTCCCCTGG ATGAAGATGG ACGGAGCTTG TTATCGCAAA TGCTGCACTA CGACCCTAAC 
AAGCGGATTT CGGCCAAGGC AGCCCTGGCT CACCCTTTCT TCCAGGATGT GACCAAGCCA 
GTACCCCATC TTCGACTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Amplification of SMYD3 promotes tumorigenicity and intrahepatic metastasis of hepatocellular carcinoma via upregulation of CDK2 and MMP2.
Oncogene38(25)4948-4961(2019 06)
Wang Y,Xie BH,Lin WH,Huang YH,Ni JY,Hu J,Cui W,Zhou J,Shen L,Xu LF,Lian F,Li HP

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Nature immunology20(4)493-502(2019 04)
Hubel P,Urban C,Bergant V,Schneider WM,Knauer B,Stukalov A,Scaturro P,Mann A,Brunotte L,Hoffmann HH,Schoggins JW,Schwemmle M,Mann M,Rice CM,Pichlmair A

Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe.
The Journal of biological chemistry294(6)1763-1778(2019 02)
Warren NJH,Eastman A

Function of the amino-terminal region of human MCM4 in helicase activity.
Journal of biochemistry164(6)449-460(2018 Dec)
Wang X,Ishimi Y

A type 2 diabetes disease module with a high collective influence for Cdk2 and PTPLAD1 is localized in endosomes.
PloS one13(10)e0205180(2018)
Boutchueng-Djidjou M,Belleau P,Bilodeau N,Fortier S,Bourassa S,Droit A,Elowe S,Faure RL

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CDK2 cDNA ORF clone, Homo sapiens(human)

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ORF Insert Sequence:

Target ORF information:

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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