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a Related Biological Terms:

decorated thin filament

A thin filament of muscle, i.e. F-actin, to which are attached globular heads. The S1 fragments of myosin resemble in electron micrographs a string with attached arrowheads, all angled towards one end of the string.

degeneracy

Redundancy of the genetic code, in that each amino acid is specified by more than one codon.

degenerate oligonucleotide primed PCR (DOP)

(see coincidence painting (chromosome painting))

dehydrogenation

The oxidation of a compound by removal of equal numbers of protons and electrons, usually two of each.

delayed-early stage

(see immediate-early stage)

deletion map

The linear arrangement of natural mutations along a chromosome or part of a chromosome. In the first phase many individuals are studied for the presence of cytogenetic markers; later phases use restriction fragment length polymorphisms to detail the chemical nature of the aberrations. Vollrath, D., Foote, S., Hilton, A., et al. (1992) Science 258, 52-59

deletion mapping

The assignment of the relative positions of deletion mutations along chromosomes. In the first phase, many individuals are studies for the presence of cytogenetic markers and later phases use restriction fragment length polymorphisms to detail the chemical nature of the aberrations. Futhermore, an experimental approach for identifying the location of a point mutation by testing whether recombination with a gene with a known deletion will produce the wild-type protein, in which case the site of point mutation lies outside the deleted region, or whether it fails to produce the wild-type protein, in which case the point mutation lies within the deleted region. A sufficiently large number of deletion mutants will narrow the location of the point mutation to a single nucleotide.Vollrath, D., Foote, S., Hilton, A., Brown, L.G., Beer-Romero, P., Bogen, J.S. and Page, D.C. (1992) Science 258, 52-59 Learn more about sgRNA.

deletion mutation

A mutation caused by the absence of one of more nucleotides in the DNA sequence.

delta restriction cloning

A method for the use of a single primer to determine a DNA sequence longer than would normally be practical for a single sequencing attempt. After the first sequencing the bulk of the determined sequence is excised and the plasmid re-ligated, so that the primer is just upstream from the remaining undetermined sequence. The procedure may be repeated indefinitely until a large sequence is determined.

denaturation

The destruction of the ordered folding of a protein or nucleic acid that is required for its normal function. Protein denaturation often involves a change from a specific globular or fibrous conformation to a random coil; nucleic acid denaturation often involves the dissociation of a duplex into single strands. (see also native structure) Related tool: molecular biology tools

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