app.L cDNA ORF clone, Xenopus laevis(African clawed frog)

Gene
Clones
gRNAs

Summary

Gene Symbol	app.L
Entrez Gene ID	398223
Full Name	amyloid beta precursor protein L homeolog
Synonyms	app
General protein information	Preferred Names amyloid beta precursor protein L homeolog Names amyloid beta (A4) precursor protein L homeolog amyloid beta precursor protein L homeolog beta-amyloid precursor protein A
Gene Type	protein-coding
Organism	Xenopus laevis(African clawed frog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001088629.1	NP_001082098.1	amyloid beta precursor protein L homeolog precursor
XM_018244879.1	XP_018100368.1	amyloid beta (A4) precursor protein L homeolog isoform X3
XM_018244877.1	XP_018100366.1	amyloid beta (A4) precursor protein L homeolog isoform X1
XM_018244878.1	XP_018100367.1	amyloid beta (A4) precursor protein L homeolog isoform X2

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Endogenous C-terminal fragments of beta-amyloid precursor protein from Xenopus laevis skin exudate.
Clamagirand C, El Abida B, Der Garabedian PA, Hanquez C, Dubost L, Marie A, Rholam M, Friguet B, Cohen P
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology146(4)530-9(2007 Apr)

Biosynthesis and differential processing of two pools of amyloid-beta precursor protein in a physiologically inducible neuroendocrine cell.
Collin RW, van den Hurk WH, Martens GJ
Journal of neurochemistry94(4)1015-24(2005 Aug)

Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.
Maloney B, Ge YW, Greig N, Lahiri DK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology18(11)1288-90(2004 Aug)

Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative.
Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW, Richardson P
Developmental dynamics : an official publication of the American Association of Anatomists225(4)384-91(2002 Dec)

Expression of the gene encoding the beta-amyloid precursor protein APP in Xenopus laevis.
van den Hurk WH, Bloemen M, Martens GJ
Brain research. Molecular brain research97(1)13-20(2001 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following app.L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the app.L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OAf06075	NM_001088629.1 Latest version!	Xenopus laevis amyloid beta precursor protein L homeolog (app.L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OAf18780	XM_018244877.1 Latest version!	Xenopus laevis amyloid beta (A4) precursor protein L homeolog (app.L), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OAf18781	XM_018244878.1 Latest version!	Xenopus laevis amyloid beta (A4) precursor protein L homeolog (app.L), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OAf18782	XM_018244879.1 Latest version!	Xenopus laevis amyloid beta (A4) precursor protein L homeolog (app.L), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

app.L ( NM_001088629.1 ) cDNA ORF clone, Xenopus laevis(African clawed frog) -> NP_001082098.1 Xenopus laevis amyloid beta precursor protein L homeolog (app.L), mRNA.

Price & Availability↑

CloneID	OAf06075
Clone ID Related Accession (Same CDS sequence)	NM_001088629.1
Accession Version	NM_001088629.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2250bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1488384000000
Organism	Xenopus laevis(African clawed frog)
Product	amyloid beta precursor protein L homeolog precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC070668.1. On Jul 25, 2007 this sequence version replaced NM_001088630.1. ##Evidence-Data-START## Transcript exon combination :: BC070668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00012418, SAMD00012419 [ECO:0000348] ##Evidence-Data-END##

ATGCTGCCCC ATATAACGCT GCTCGTGCTG ACTGCCGGAG CGCTAGCGCT GGAGGTGCCA 
GCAGATGGAA ATGGAGGCCT GTTGGCAGAG CCACAGATTG CCATGTTCTG TGGCAAGCTG 
AATATGCACA TGAATGTTCA GAATGGGAAA TGGGAGACTG ATGTGTCCGG GACAAAGGGC 
TGCATTGGAA CCAAGGAAGG AATCCTTCAG TACTGTCAGG AGGTATACCC AGAGCTGCAG 
ATTACCAACG TTGTTGAAGC CAACCAGCCG GTGACAATCC AGAATTGGTG CAAGAAAGGA 
CGAAAGCAGT GCAAGAGCCG CACTCACATT GTGGTTCCCT ACAGATGCTT AGTCGGGGAG 
TTTGTTAGTG ATGCGCTGCT CGTTCCAGAC AAGTGCAAGT TCCTTCATCA GGAAAGGATG 
GACATTTGTG AAACTCACCT GCACTGGCAC ACTGTGGCCA AAGAGTCCTG CAGTGAGAAG 
AGCATGAGTC TCCATGAATA CGGAATGCTC CTTCCATGTG GAATCGATAA ATTCCGGGGA 
GTGGAGTTTG TGTGCTGCCC GTCTGCCGAA GAAAGCGAAA GCTTTGACTC CGCAGATGCA 
GAGGATGATT CTGACGTCTG GTGGGGAGGT GCTGATGCCG ATTATGTGGA TAGAAGTGAT 
GACAAGGCTG TAGAAGCCCA ACCAGATGAA GAGGAGGAGG TTGTAGAGGT GGAAGAGGAG 
GAAACGGATG ATGATGAGGA CGATGGGGAT GAAGCCGAGG AAGAACCCGA GGAACCCTAT 
GAAGAAGCCA CCGAAAGAAC AACAAGTATA GCCACTACCA CCACTACTAC TACAGAGTCT 
GTGGAAGAAG TTGTAAGAGA GGTGTGCTCT GAGCAAGCTG AGACTGGACC CTGTCGAGCA 
ATGATCTCCC GCTGGTATTA TGATGTGACG GAAAGCAAAT GCGCCCAGTT CATTTATGGA 
GGCTGTGGCG GGAACCGAAA CAACTTTGAG TCTGACGATT ACTGCATGGC AGTCTGTGGC 
AGCGTCATTC CCGCCACAGC TGCCAGCACC CCTGACGCAG TTGACAAGTA CCTGGAGAAC 
CCGAATGATG AGAACGAGCA CGACCGCTTC CTGAAAGCAA AGGAGAGGCT GGAGGGCAAG 
CACCGCGAGA AGATGTCTGA GGTGATGAAG GAATGGGAAG AAGCTGAACG CCAGGCAAAG 
AACCTTCCCA AGGCTGACAA GAAGGCAGTA ATACAGCATT TCCAGGAGAA AGTGGAATCC 
CTAGAACAAG AAGCTGCAAA CGAAAGGCAA CAACTGGTCG AGACCCATAT GGCCCGAGTG 
GAAGCCATGT TAAATGATCG TCGACGAATC GCCCTGGAGA ACTACATCAC TGCTCTGCAA 
GCTGATCCTC CACGGCCCCG CCATGTGTTC AACATGCTGA AGAAGTACGT GCGGGCCGAG 
CAGAAGGACA GACAGCACAC TCTCAAACAC TTTGAGCATG TCCGTATGGT AGATCCCAAG 
AAGGCGGCTC AAATCCGATC TCAGGTAATG ACACACCTTC GAGTGATAAA CGAGAGAATG 
AACCAGAGCT TCTCACTCCT CTACAAGGTG CCGGCCGTGG CTGAGGAAAT CCAGGATGAA 
GTCGATGAAC TCTTCCAGAA GGAGCAGAAC TACTCAGATG ACATGGTGTC CAACATGGTG 
AGCGACCACA GAGTCAGCTA CGGGAACGAT GCCCTGATGC CTTCTCTCAG CGAGACCAAG 
ACCACCGTTG AGCTTCTTCC CGTAGATGGA GAGTTCAACA TAGAGGACCT CCAGCCCTGG 
CATTCATTCG GGGTGGACTC TGTTCCAGCA AACACTGAGA ATGAAGTCGA ACCAGTGGAC 
GCCCGCCCTG CTGCAGATAG AGGGCTCACT ACACGCCCAG GCTCGGGACT GACCAATATC 
AAAACAGAAG AAATCTCAGA GGTGAAGATG GATTCTGAAT ATAGACACGA TACTGCCTAT 
GAAGTGCACC ATCAGAAACT GGTCTTCTTC GCAGAGGAAG TGGGATCAAA CAAAGGAGCA 
ATCATTGGTC TGATGGTGGG GGGCGTTGTC ATAGCAACGG TGATAGTCAT CACTTTAGTG 
ATGCTGAAGA AGAAGCAATA CACAACTATC CATCATGGAG TAGTAGAGGT GGACGCGGCG 
GTGACCCCAG AAGAGCGCCA CCTCACCAAG ATGCAGCAGA ACGGCTACGA GAACCCAACG 
TACAAGTTCT TCGAACAGAT GCAGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001082098.1
CDS	128..2377
Translation	MLPHITLLVLTAGALALEVPADGNGGLLAEPQIAMFCGKLNMHMNVQNGKWETDVSGTKGCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKKGRKQCKSRTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDICETHLHWHTVAKESCSEKSMSLHEYGMLLPCGIDKFRGVEFVCCPSAEESESFDSADAEDDSDVWWGGADADYVDRSDDKAVEAQPDEEEEVVEVEEEETDDDEDDGDEAEEEPEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYYDVTESKCAQFIYGGCGGNRNNFESDDYCMAVCGSVIPATAASTPDAVDKYLENPNDENEHDRFLKAKERLEGKHREKMSEVMKEWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRIALENYITALQADPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVINERMNQSFSLLYKVPAVAEEIQDEVDELFQKEQNYSDDMVSNMVSDHRVSYGNDALMPSLSETKTTVELLPVDGEFNIEDLQPWHSFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDSEYRHDTAYEVHHQKLVFFAEEVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTTIHHGVVEVDAAVTPEERHLTKMQQNGYENPTYKFFEQMQN

Target ORF information:

RefSeq Version	NM_001088629.1
Organism	Xenopus laevis(African clawed frog)
Definition	Xenopus laevis amyloid beta precursor protein L homeolog (app.L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001088629.1

ORF Insert Sequence:

ATGCTGCCCC ATATAACGCT GCTCGTGCTG ACTGCCGGAG CGCTAGCGCT GGAGGTGCCA 
GCAGATGGAA ATGGAGGCCT GTTGGCAGAG CCACAGATTG CCATGTTCTG TGGCAAGCTG 
AATATGCACA TGAATGTTCA GAATGGGAAA TGGGAGACTG ATGTGTCCGG GACAAAGGGC 
TGCATTGGAA CCAAGGAAGG AATCCTTCAG TACTGTCAGG AGGTATACCC AGAGCTGCAG 
ATTACCAACG TTGTTGAAGC CAACCAGCCG GTGACAATCC AGAATTGGTG CAAGAAAGGA 
CGAAAGCAGT GCAAGAGCCG CACTCACATT GTGGTTCCCT ACAGATGCTT AGTCGGGGAG 
TTTGTTAGTG ATGCGCTGCT CGTTCCAGAC AAGTGCAAGT TCCTTCATCA GGAAAGGATG 
GACATTTGTG AAACTCACCT GCACTGGCAC ACTGTGGCCA AAGAGTCCTG CAGTGAGAAG 
AGCATGAGTC TCCATGAATA CGGAATGCTC CTTCCATGTG GAATCGATAA ATTCCGGGGA 
GTGGAGTTTG TGTGCTGCCC GTCTGCCGAA GAAAGCGAAA GCTTTGACTC CGCAGATGCA 
GAGGATGATT CTGACGTCTG GTGGGGAGGT GCTGATGCCG ATTATGTGGA TAGAAGTGAT 
GACAAGGCTG TAGAAGCCCA ACCAGATGAA GAGGAGGAGG TTGTAGAGGT GGAAGAGGAG 
GAAACGGATG ATGATGAGGA CGATGGGGAT GAAGCCGAGG AAGAACCCGA GGAACCCTAT 
GAAGAAGCCA CCGAAAGAAC AACAAGTATA GCCACTACCA CCACTACTAC TACAGAGTCT 
GTGGAAGAAG TTGTAAGAGA GGTGTGCTCT GAGCAAGCTG AGACTGGACC CTGTCGAGCA 
ATGATCTCCC GCTGGTATTA TGATGTGACG GAAAGCAAAT GCGCCCAGTT CATTTATGGA 
GGCTGTGGCG GGAACCGAAA CAACTTTGAG TCTGACGATT ACTGCATGGC AGTCTGTGGC 
AGCGTCATTC CCGCCACAGC TGCCAGCACC CCTGACGCAG TTGACAAGTA CCTGGAGAAC 
CCGAATGATG AGAACGAGCA CGACCGCTTC CTGAAAGCAA AGGAGAGGCT GGAGGGCAAG 
CACCGCGAGA AGATGTCTGA GGTGATGAAG GAATGGGAAG AAGCTGAACG CCAGGCAAAG 
AACCTTCCCA AGGCTGACAA GAAGGCAGTA ATACAGCATT TCCAGGAGAA AGTGGAATCC 
CTAGAACAAG AAGCTGCAAA CGAAAGGCAA CAACTGGTCG AGACCCATAT GGCCCGAGTG 
GAAGCCATGT TAAATGATCG TCGACGAATC GCCCTGGAGA ACTACATCAC TGCTCTGCAA 
GCTGATCCTC CACGGCCCCG CCATGTGTTC AACATGCTGA AGAAGTACGT GCGGGCCGAG 
CAGAAGGACA GACAGCACAC TCTCAAACAC TTTGAGCATG TCCGTATGGT AGATCCCAAG 
AAGGCGGCTC AAATCCGATC TCAGGTAATG ACACACCTTC GAGTGATAAA CGAGAGAATG 
AACCAGAGCT TCTCACTCCT CTACAAGGTG CCGGCCGTGG CTGAGGAAAT CCAGGATGAA 
GTCGATGAAC TCTTCCAGAA GGAGCAGAAC TACTCAGATG ACATGGTGTC CAACATGGTG 
AGCGACCACA GAGTCAGCTA CGGGAACGAT GCCCTGATGC CTTCTCTCAG CGAGACCAAG 
ACCACCGTTG AGCTTCTTCC CGTAGATGGA GAGTTCAACA TAGAGGACCT CCAGCCCTGG 
CATTCATTCG GGGTGGACTC TGTTCCAGCA AACACTGAGA ATGAAGTCGA ACCAGTGGAC 
GCCCGCCCTG CTGCAGATAG AGGGCTCACT ACACGCCCAG GCTCGGGACT GACCAATATC 
AAAACAGAAG AAATCTCAGA GGTGAAGATG GATTCTGAAT ATAGACACGA TACTGCCTAT 
GAAGTGCACC ATCAGAAACT GGTCTTCTTC GCAGAGGAAG TGGGATCAAA CAAAGGAGCA 
ATCATTGGTC TGATGGTGGG GGGCGTTGTC ATAGCAACGG TGATAGTCAT CACTTTAGTG 
ATGCTGAAGA AGAAGCAATA CACAACTATC CATCATGGAG TAGTAGAGGT GGACGCGGCG 
GTGACCCCAG AAGAGCGCCA CCTCACCAAG ATGCAGCAGA ACGGCTACGA GAACCCAACG 
TACAAGTTCT TCGAACAGAT GCAGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

app.L ( XM_018244877.1 ) cDNA ORF clone, Xenopus laevis(African clawed frog) -> XP_018100366.1 Xenopus laevis amyloid beta (A4) precursor protein L homeolog (app.L), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OAf18780
Clone ID Related Accession (Same CDS sequence)	XM_018244877.1
Accession Version	XM_018244877.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2253bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1474214400000
Organism	Xenopus laevis(African clawed frog)
Product	amyloid beta (A4) precursor protein L homeolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_030726.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Xenopus laevis Annotation Release 100 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCCCC ATATAACGCT GCTCGTGCTG ACTGTCGGAG CGCTAGCGCT GGAGGTGCCA 
GCAGATGGAA ATGGAGGCCT GTTGGCAGAG CCACAGATTG CCATGTTCTG TGGCAAGCTG 
AATATGCACA TGAATGTTCA GAATGGGAAA TGGGAGACTG ATGTGTCCGG GACAAAGGGC 
TGCATTGGAA CCAAGGAAGG AATCCTTCAG TACTGTCAGG AGGTATACCC AGAGCTGCAG 
ATTACCAACG TTGTTGAAGC CAACCAGCCG GTGACAATCC AGAATTGGTG CAAGAAAGGA 
CGAAAGCAGT GCAAGAGCCG CACTCACATT GTGGTTCCCT ACAGATGCTT AGTCGGGGAG 
TTTGTTAGTG ATGCGCTGCT CGTTCCAGAC AAGTGCAAGT TCCTTCATCA GGAAAGGATG 
GACATTTGTG AAACTCACCT GCACTGGCAC ACTGTGGCCA AAGAGTCCTG CAGTGAGAAG 
AGCATGAGTC TCCATGAATA CGGAATGCTC CTTCCATGTG GAATCGATAA ATTCCGGGGA 
GTGGAGTTTG TGTGCTGCCC GTCTGCCGAA GAAAGTGAAA GCTTTGACTC CGCAGATGCA 
GAGGATGATT CTGACGTCTG GTGGGGAGGT GCTGATGCCG ATTATGTGGA TAGAAGTGAT 
GACAAGGCTG TAGAAGCCCA ACCAGATGAA GAGGAGGAGG TTGTAGAGGT GGAAGAGGAG 
GAAACGGATG ATGATGAGGA CGATGGGGAT GAAGCCGAGG AAGAACCCGA GGAACCCTAT 
GAAGAAGCCA CCGAAAGAAC AACAAGTATA GCCACTACCA CCACTACTAC TACAGAGTCT 
GTGGAAGAAG TTGTAAGAGA GGTGTGCTCT GAGCAAGCTG AGACTGGACC CTGTCGAGCA 
ATGATCTCCC GCTGGTATTA TGATGTGACG GAAAGCAAAT GCGCCCAGTT CATTTATGGA 
GGCTGTGGCG GGAACCGAAA CAACTTTGAG TCTGACGATT ACTGCATGGC AGTCTGTGGC 
AGCGTCACAG TTCCCGCCAC AGCTGCCAGC ACCCCTGACG CAGTTGACAA GTACCTGGAG 
AACCCGAATG ATGAGAACGA GCACGACCGC TTCCTGAAAG CAAAGGAGAG GCTGGAGGGC 
AAGCACCGCG AGAAGATGTC TGAGGTGATG AAGGAATGGG AAGAAGCTGA ACGCCAGGCA 
AAGAACCTTC CCAAGGCTGA CAAGAAGGCA GTAATACAGC ATTTCCAGGA GAAAGTGGAA 
TCCCTAGAAC AAGAAGCTGC AAACGAAAGG CAACAACTGG TCGAGACCCA TATGGCCCGA 
GTGGAAGCCA TGTTAAATGA TCGTCGACGA ATCGCCCTGG AGAACTACAT CACTGCTCTG 
CAAGCTGATC CTCCACGGCC CCGCCATGTG TTCAACATGC TGAAGAAGTA CGTGCGGGCC 
GAGCAGAAGG ACAGACAGCA CACTCTCAAA CACTTTGAGC ATGTCCGTAT GGTAGATCCC 
AAGAAGGCGG CTCAAATCCG ATCTCAGGTA ATGACACACC TTCGAGTGAT AAACGAGAGA 
ATGAACCAGA GCTTTTCACT CCTCTACAAG GTGCCGGCCG TGGCTGAGGA AATCCAGGAT 
GAAGTCGATG AACTCTTCCA GAAGGAGCAG AACTACTCAG ATGACATGGT GTCCAACATG 
GTGAGCGACC ACAGAGTCAG CTACGGGAAC GATGCCCTGA TGCCTTCTCT CAGCGAGACC 
AAGACCACCG TTGAGCTTCT TCCCGTAGAT GGAGAGTTCA ACATAGAGGA CCTCCAGCCC 
TGGCATTCAT TCGGGGTGGA CTCTGTTCCA GCAAACACTG AGAATGAAGT CGAACCAGTG 
GACGCCCGCC CTGCTGCAGA TAGAGGGCTC ACTACACGCC CAGGCTCGGG ACTGACCAAT 
ATCAAAACAG AAGAAATCTC AGAGGTGAAG ATGGATTCTG AATATAGACA CGATACTGCC 
TATGAAGTGC ACCATCAGAA ACTGGTCTTC TTCGCAGAGG AAGTGGGATC AAACAAAGGA 
GCAATCATTG GTCTGATGGT GGGGGGCGTT GTCATAGCAA CGGTGATAGT CATCACTTTA 
GTGATGCTGA AGAAGAAGCA ATACACAACT ATCCATCATG GAGTAGTAGA GGTGGACGCG 
GCGGTGACCC CAGAAGAGCG CCACCTCACC AAGATGCAGC AGAACGGCTA CGAGAACCCA 
ACGTACAAGT TCTTCGAACA GATGCAGAAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_018100366.1
CDS	201..2453
Translation	MLPHITLLVLTVGALALEVPADGNGGLLAEPQIAMFCGKLNMHMNVQNGKWETDVSGTKGCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKKGRKQCKSRTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDICETHLHWHTVAKESCSEKSMSLHEYGMLLPCGIDKFRGVEFVCCPSAEESESFDSADAEDDSDVWWGGADADYVDRSDDKAVEAQPDEEEEVVEVEEEETDDDEDDGDEAEEEPEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYYDVTESKCAQFIYGGCGGNRNNFESDDYCMAVCGSVTVPATAASTPDAVDKYLENPNDENEHDRFLKAKERLEGKHREKMSEVMKEWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRIALENYITALQADPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVINERMNQSFSLLYKVPAVAEEIQDEVDELFQKEQNYSDDMVSNMVSDHRVSYGNDALMPSLSETKTTVELLPVDGEFNIEDLQPWHSFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDSEYRHDTAYEVHHQKLVFFAEEVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTTIHHGVVEVDAAVTPEERHLTKMQQNGYENPTYKFFEQMQN

Target ORF information:

RefSeq Version	XM_018244877.1
Organism	Xenopus laevis(African clawed frog)
Definition	Xenopus laevis amyloid beta (A4) precursor protein L homeolog (app.L), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_018244877.1

ORF Insert Sequence:

ATGCTGCCCC ATATAACGCT GCTCGTGCTG ACTGTCGGAG CGCTAGCGCT GGAGGTGCCA 
GCAGATGGAA ATGGAGGCCT GTTGGCAGAG CCACAGATTG CCATGTTCTG TGGCAAGCTG 
AATATGCACA TGAATGTTCA GAATGGGAAA TGGGAGACTG ATGTGTCCGG GACAAAGGGC 
TGCATTGGAA CCAAGGAAGG AATCCTTCAG TACTGTCAGG AGGTATACCC AGAGCTGCAG 
ATTACCAACG TTGTTGAAGC CAACCAGCCG GTGACAATCC AGAATTGGTG CAAGAAAGGA 
CGAAAGCAGT GCAAGAGCCG CACTCACATT GTGGTTCCCT ACAGATGCTT AGTCGGGGAG 
TTTGTTAGTG ATGCGCTGCT CGTTCCAGAC AAGTGCAAGT TCCTTCATCA GGAAAGGATG 
GACATTTGTG AAACTCACCT GCACTGGCAC ACTGTGGCCA AAGAGTCCTG CAGTGAGAAG 
AGCATGAGTC TCCATGAATA CGGAATGCTC CTTCCATGTG GAATCGATAA ATTCCGGGGA 
GTGGAGTTTG TGTGCTGCCC GTCTGCCGAA GAAAGTGAAA GCTTTGACTC CGCAGATGCA 
GAGGATGATT CTGACGTCTG GTGGGGAGGT GCTGATGCCG ATTATGTGGA TAGAAGTGAT 
GACAAGGCTG TAGAAGCCCA ACCAGATGAA GAGGAGGAGG TTGTAGAGGT GGAAGAGGAG 
GAAACGGATG ATGATGAGGA CGATGGGGAT GAAGCCGAGG AAGAACCCGA GGAACCCTAT 
GAAGAAGCCA CCGAAAGAAC AACAAGTATA GCCACTACCA CCACTACTAC TACAGAGTCT 
GTGGAAGAAG TTGTAAGAGA GGTGTGCTCT GAGCAAGCTG AGACTGGACC CTGTCGAGCA 
ATGATCTCCC GCTGGTATTA TGATGTGACG GAAAGCAAAT GCGCCCAGTT CATTTATGGA 
GGCTGTGGCG GGAACCGAAA CAACTTTGAG TCTGACGATT ACTGCATGGC AGTCTGTGGC 
AGCGTCACAG TTCCCGCCAC AGCTGCCAGC ACCCCTGACG CAGTTGACAA GTACCTGGAG 
AACCCGAATG ATGAGAACGA GCACGACCGC TTCCTGAAAG CAAAGGAGAG GCTGGAGGGC 
AAGCACCGCG AGAAGATGTC TGAGGTGATG AAGGAATGGG AAGAAGCTGA ACGCCAGGCA 
AAGAACCTTC CCAAGGCTGA CAAGAAGGCA GTAATACAGC ATTTCCAGGA GAAAGTGGAA 
TCCCTAGAAC AAGAAGCTGC AAACGAAAGG CAACAACTGG TCGAGACCCA TATGGCCCGA 
GTGGAAGCCA TGTTAAATGA TCGTCGACGA ATCGCCCTGG AGAACTACAT CACTGCTCTG 
CAAGCTGATC CTCCACGGCC CCGCCATGTG TTCAACATGC TGAAGAAGTA CGTGCGGGCC 
GAGCAGAAGG ACAGACAGCA CACTCTCAAA CACTTTGAGC ATGTCCGTAT GGTAGATCCC 
AAGAAGGCGG CTCAAATCCG ATCTCAGGTA ATGACACACC TTCGAGTGAT AAACGAGAGA 
ATGAACCAGA GCTTTTCACT CCTCTACAAG GTGCCGGCCG TGGCTGAGGA AATCCAGGAT 
GAAGTCGATG AACTCTTCCA GAAGGAGCAG AACTACTCAG ATGACATGGT GTCCAACATG 
GTGAGCGACC ACAGAGTCAG CTACGGGAAC GATGCCCTGA TGCCTTCTCT CAGCGAGACC 
AAGACCACCG TTGAGCTTCT TCCCGTAGAT GGAGAGTTCA ACATAGAGGA CCTCCAGCCC 
TGGCATTCAT TCGGGGTGGA CTCTGTTCCA GCAAACACTG AGAATGAAGT CGAACCAGTG 
GACGCCCGCC CTGCTGCAGA TAGAGGGCTC ACTACACGCC CAGGCTCGGG ACTGACCAAT 
ATCAAAACAG AAGAAATCTC AGAGGTGAAG ATGGATTCTG AATATAGACA CGATACTGCC 
TATGAAGTGC ACCATCAGAA ACTGGTCTTC TTCGCAGAGG AAGTGGGATC AAACAAAGGA 
GCAATCATTG GTCTGATGGT GGGGGGCGTT GTCATAGCAA CGGTGATAGT CATCACTTTA 
GTGATGCTGA AGAAGAAGCA ATACACAACT ATCCATCATG GAGTAGTAGA GGTGGACGCG 
GCGGTGACCC CAGAAGAGCG CCACCTCACC AAGATGCAGC AGAACGGCTA CGAGAACCCA 
ACGTACAAGT TCTTCGAACA GATGCAGAAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

app.L ( XM_018244878.1 ) cDNA ORF clone, Xenopus laevis(African clawed frog) -> XP_018100367.1 Xenopus laevis amyloid beta (A4) precursor protein L homeolog (app.L), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OAf18781
Clone ID Related Accession (Same CDS sequence)	XM_018244878.1
Accession Version	XM_018244878.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2085bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1474214400000
Organism	Xenopus laevis(African clawed frog)
Product	amyloid beta (A4) precursor protein L homeolog isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_030726.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Xenopus laevis Annotation Release 100 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCCCC ATATAACGCT GCTCGTGCTG ACTGTCGGAG CGCTAGCGCT GGAGGTGCCA 
GCAGATGGAA ATGGAGGCCT GTTGGCAGAG CCACAGATTG CCATGTTCTG TGGCAAGCTG 
AATATGCACA TGAATGTTCA GAATGGGAAA TGGGAGACTG ATGTGTCCGG GACAAAGGGC 
TGCATTGGAA CCAAGGAAGG AATCCTTCAG TACTGTCAGG AGGTATACCC AGAGCTGCAG 
ATTACCAACG TTGTTGAAGC CAACCAGCCG GTGACAATCC AGAATTGGTG CAAGAAAGGA 
CGAAAGCAGT GCAAGAGCCG CACTCACATT GTGGTTCCCT ACAGATGCTT AGTCGGGGAG 
TTTGTTAGTG ATGCGCTGCT CGTTCCAGAC AAGTGCAAGT TCCTTCATCA GGAAAGGATG 
GACATTTGTG AAACTCACCT GCACTGGCAC ACTGTGGCCA AAGAGTCCTG CAGTGAGAAG 
AGCATGAGTC TCCATGAATA CGGAATGCTC CTTCCATGTG GAATCGATAA ATTCCGGGGA 
GTGGAGTTTG TGTGCTGCCC GTCTGCCGAA GAAAGTGAAA GCTTTGACTC CGCAGATGCA 
GAGGATGATT CTGACGTCTG GTGGGGAGGT GCTGATGCCG ATTATGTGGA TAGAAGTGAT 
GACAAGGCTG TAGAAGCCCA ACCAGATGAA GAGGAGGAGG TTGTAGAGGT GGAAGAGGAG 
GAAACGGATG ATGATGAGGA CGATGGGGAT GAAGCCGAGG AAGAACCCGA GGAACCCTAT 
GAAGAAGCCA CCGAAAGAAC AACAAGTATA GCCACTACCA CCACTACTAC TACAGAGTCT 
GTGGAAGAAG TTGTAAGAGC AGTTCCCGCC ACAGCTGCCA GCACCCCTGA CGCAGTTGAC 
AAGTACCTGG AGAACCCGAA TGATGAGAAC GAGCACGACC GCTTCCTGAA AGCAAAGGAG 
AGGCTGGAGG GCAAGCACCG CGAGAAGATG TCTGAGGTGA TGAAGGAATG GGAAGAAGCT 
GAACGCCAGG CAAAGAACCT TCCCAAGGCT GACAAGAAGG CAGTAATACA GCATTTCCAG 
GAGAAAGTGG AATCCCTAGA ACAAGAAGCT GCAAACGAAA GGCAACAACT GGTCGAGACC 
CATATGGCCC GAGTGGAAGC CATGTTAAAT GATCGTCGAC GAATCGCCCT GGAGAACTAC 
ATCACTGCTC TGCAAGCTGA TCCTCCACGG CCCCGCCATG TGTTCAACAT GCTGAAGAAG 
TACGTGCGGG CCGAGCAGAA GGACAGACAG CACACTCTCA AACACTTTGA GCATGTCCGT 
ATGGTAGATC CCAAGAAGGC GGCTCAAATC CGATCTCAGG TAATGACACA CCTTCGAGTG 
ATAAACGAGA GAATGAACCA GAGCTTTTCA CTCCTCTACA AGGTGCCGGC CGTGGCTGAG 
GAAATCCAGG ATGAAGTCGA TGAACTCTTC CAGAAGGAGC AGAACTACTC AGATGACATG 
GTGTCCAACA TGGTGAGCGA CCACAGAGTC AGCTACGGGA ACGATGCCCT GATGCCTTCT 
CTCAGCGAGA CCAAGACCAC CGTTGAGCTT CTTCCCGTAG ATGGAGAGTT CAACATAGAG 
GACCTCCAGC CCTGGCATTC ATTCGGGGTG GACTCTGTTC CAGCAAACAC TGAGAATGAA 
GTCGAACCAG TGGACGCCCG CCCTGCTGCA GATAGAGGGC TCACTACACG CCCAGGCTCG 
GGACTGACCA ATATCAAAAC AGAAGAAATC TCAGAGGTGA AGATGGATTC TGAATATAGA 
CACGATACTG CCTATGAAGT GCACCATCAG AAACTGGTCT TCTTCGCAGA GGAAGTGGGA 
TCAAACAAAG GAGCAATCAT TGGTCTGATG GTGGGGGGCG TTGTCATAGC AACGGTGATA 
GTCATCACTT TAGTGATGCT GAAGAAGAAG CAATACACAA CTATCCATCA TGGAGTAGTA 
GAGGTGGACG CGGCGGTGAC CCCAGAAGAG CGCCACCTCA CCAAGATGCA GCAGAACGGC 
TACGAGAACC CAACGTACAA GTTCTTCGAA CAGATGCAGA ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_018100367.1
CDS	200..2284
Translation	MLPHITLLVLTVGALALEVPADGNGGLLAEPQIAMFCGKLNMHMNVQNGKWETDVSGTKGCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKKGRKQCKSRTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDICETHLHWHTVAKESCSEKSMSLHEYGMLLPCGIDKFRGVEFVCCPSAEESESFDSADAEDDSDVWWGGADADYVDRSDDKAVEAQPDEEEEVVEVEEEETDDDEDDGDEAEEEPEEPYEEATERTTSIATTTTTTTESVEEVVRAVPATAASTPDAVDKYLENPNDENEHDRFLKAKERLEGKHREKMSEVMKEWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRIALENYITALQADPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVINERMNQSFSLLYKVPAVAEEIQDEVDELFQKEQNYSDDMVSNMVSDHRVSYGNDALMPSLSETKTTVELLPVDGEFNIEDLQPWHSFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDSEYRHDTAYEVHHQKLVFFAEEVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTTIHHGVVEVDAAVTPEERHLTKMQQNGYENPTYKFFEQMQN

Target ORF information:

RefSeq Version	XM_018244878.1
Organism	Xenopus laevis(African clawed frog)
Definition	Xenopus laevis amyloid beta (A4) precursor protein L homeolog (app.L), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_018244878.1

ORF Insert Sequence:

ATGCTGCCCC ATATAACGCT GCTCGTGCTG ACTGTCGGAG CGCTAGCGCT GGAGGTGCCA 
GCAGATGGAA ATGGAGGCCT GTTGGCAGAG CCACAGATTG CCATGTTCTG TGGCAAGCTG 
AATATGCACA TGAATGTTCA GAATGGGAAA TGGGAGACTG ATGTGTCCGG GACAAAGGGC 
TGCATTGGAA CCAAGGAAGG AATCCTTCAG TACTGTCAGG AGGTATACCC AGAGCTGCAG 
ATTACCAACG TTGTTGAAGC CAACCAGCCG GTGACAATCC AGAATTGGTG CAAGAAAGGA 
CGAAAGCAGT GCAAGAGCCG CACTCACATT GTGGTTCCCT ACAGATGCTT AGTCGGGGAG 
TTTGTTAGTG ATGCGCTGCT CGTTCCAGAC AAGTGCAAGT TCCTTCATCA GGAAAGGATG 
GACATTTGTG AAACTCACCT GCACTGGCAC ACTGTGGCCA AAGAGTCCTG CAGTGAGAAG 
AGCATGAGTC TCCATGAATA CGGAATGCTC CTTCCATGTG GAATCGATAA ATTCCGGGGA 
GTGGAGTTTG TGTGCTGCCC GTCTGCCGAA GAAAGTGAAA GCTTTGACTC CGCAGATGCA 
GAGGATGATT CTGACGTCTG GTGGGGAGGT GCTGATGCCG ATTATGTGGA TAGAAGTGAT 
GACAAGGCTG TAGAAGCCCA ACCAGATGAA GAGGAGGAGG TTGTAGAGGT GGAAGAGGAG 
GAAACGGATG ATGATGAGGA CGATGGGGAT GAAGCCGAGG AAGAACCCGA GGAACCCTAT 
GAAGAAGCCA CCGAAAGAAC AACAAGTATA GCCACTACCA CCACTACTAC TACAGAGTCT 
GTGGAAGAAG TTGTAAGAGC AGTTCCCGCC ACAGCTGCCA GCACCCCTGA CGCAGTTGAC 
AAGTACCTGG AGAACCCGAA TGATGAGAAC GAGCACGACC GCTTCCTGAA AGCAAAGGAG 
AGGCTGGAGG GCAAGCACCG CGAGAAGATG TCTGAGGTGA TGAAGGAATG GGAAGAAGCT 
GAACGCCAGG CAAAGAACCT TCCCAAGGCT GACAAGAAGG CAGTAATACA GCATTTCCAG 
GAGAAAGTGG AATCCCTAGA ACAAGAAGCT GCAAACGAAA GGCAACAACT GGTCGAGACC 
CATATGGCCC GAGTGGAAGC CATGTTAAAT GATCGTCGAC GAATCGCCCT GGAGAACTAC 
ATCACTGCTC TGCAAGCTGA TCCTCCACGG CCCCGCCATG TGTTCAACAT GCTGAAGAAG 
TACGTGCGGG CCGAGCAGAA GGACAGACAG CACACTCTCA AACACTTTGA GCATGTCCGT 
ATGGTAGATC CCAAGAAGGC GGCTCAAATC CGATCTCAGG TAATGACACA CCTTCGAGTG 
ATAAACGAGA GAATGAACCA GAGCTTTTCA CTCCTCTACA AGGTGCCGGC CGTGGCTGAG 
GAAATCCAGG ATGAAGTCGA TGAACTCTTC CAGAAGGAGC AGAACTACTC AGATGACATG 
GTGTCCAACA TGGTGAGCGA CCACAGAGTC AGCTACGGGA ACGATGCCCT GATGCCTTCT 
CTCAGCGAGA CCAAGACCAC CGTTGAGCTT CTTCCCGTAG ATGGAGAGTT CAACATAGAG 
GACCTCCAGC CCTGGCATTC ATTCGGGGTG GACTCTGTTC CAGCAAACAC TGAGAATGAA 
GTCGAACCAG TGGACGCCCG CCCTGCTGCA GATAGAGGGC TCACTACACG CCCAGGCTCG 
GGACTGACCA ATATCAAAAC AGAAGAAATC TCAGAGGTGA AGATGGATTC TGAATATAGA 
CACGATACTG CCTATGAAGT GCACCATCAG AAACTGGTCT TCTTCGCAGA GGAAGTGGGA 
TCAAACAAAG GAGCAATCAT TGGTCTGATG GTGGGGGGCG TTGTCATAGC AACGGTGATA 
GTCATCACTT TAGTGATGCT GAAGAAGAAG CAATACACAA CTATCCATCA TGGAGTAGTA 
GAGGTGGACG CGGCGGTGAC CCCAGAAGAG CGCCACCTCA CCAAGATGCA GCAGAACGGC 
TACGAGAACC CAACGTACAA GTTCTTCGAA CAGATGCAGA ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

app.L ( XM_018244879.1 ) cDNA ORF clone, Xenopus laevis(African clawed frog) -> XP_018100368.1 Xenopus laevis amyloid beta (A4) precursor protein L homeolog (app.L), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OAf18782
Clone ID Related Accession (Same CDS sequence)	XM_018244879.1
Accession Version	XM_018244879.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2082bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1474214400000
Organism	Xenopus laevis(African clawed frog)
Product	amyloid beta (A4) precursor protein L homeolog isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_030726.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Xenopus laevis Annotation Release 100 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCCCC ATATAACGCT GCTCGTGCTG ACTGTCGGAG CGCTAGCGCT GGAGGTGCCA 
GCAGATGGAA ATGGAGGCCT GTTGGCAGAG CCACAGATTG CCATGTTCTG TGGCAAGCTG 
AATATGCACA TGAATGTTCA GAATGGGAAA TGGGAGACTG ATGTGTCCGG GACAAAGGGC 
TGCATTGGAA CCAAGGAAGG AATCCTTCAG TACTGTCAGG AGGTATACCC AGAGCTGCAG 
ATTACCAACG TTGTTGAAGC CAACCAGCCG GTGACAATCC AGAATTGGTG CAAGAAAGGA 
CGAAAGCAGT GCAAGAGCCG CACTCACATT GTGGTTCCCT ACAGATGCTT AGTCGGGGAG 
TTTGTTAGTG ATGCGCTGCT CGTTCCAGAC AAGTGCAAGT TCCTTCATCA GGAAAGGATG 
GACATTTGTG AAACTCACCT GCACTGGCAC ACTGTGGCCA AAGAGTCCTG CAGTGAGAAG 
AGCATGAGTC TCCATGAATA CGGAATGCTC CTTCCATGTG GAATCGATAA ATTCCGGGGA 
GTGGAGTTTG TGTGCTGCCC GTCTGCCGAA GAAAGTGAAA GCTTTGACTC CGCAGATGCA 
GAGGATGATT CTGACGTCTG GTGGGGAGGT GCTGATGCCG ATTATGTGGA TAGAAGTGAT 
GACAAGGCTG TAGAAGCCCA ACCAGATGAA GAGGAGGAGG TTGTAGAGGT GGAAGAGGAG 
GAAACGGATG ATGATGAGGA CGATGGGGAT GAAGCCGAGG AAGAACCCGA GGAACCCTAT 
GAAGAAGCCA CCGAAAGAAC AACAAGTATA GCCACTACCA CCACTACTAC TACAGAGTCT 
GTGGAAGAAG TTGTAAGAGT TCCCGCCACA GCTGCCAGCA CCCCTGACGC AGTTGACAAG 
TACCTGGAGA ACCCGAATGA TGAGAACGAG CACGACCGCT TCCTGAAAGC AAAGGAGAGG 
CTGGAGGGCA AGCACCGCGA GAAGATGTCT GAGGTGATGA AGGAATGGGA AGAAGCTGAA 
CGCCAGGCAA AGAACCTTCC CAAGGCTGAC AAGAAGGCAG TAATACAGCA TTTCCAGGAG 
AAAGTGGAAT CCCTAGAACA AGAAGCTGCA AACGAAAGGC AACAACTGGT CGAGACCCAT 
ATGGCCCGAG TGGAAGCCAT GTTAAATGAT CGTCGACGAA TCGCCCTGGA GAACTACATC 
ACTGCTCTGC AAGCTGATCC TCCACGGCCC CGCCATGTGT TCAACATGCT GAAGAAGTAC 
GTGCGGGCCG AGCAGAAGGA CAGACAGCAC ACTCTCAAAC ACTTTGAGCA TGTCCGTATG 
GTAGATCCCA AGAAGGCGGC TCAAATCCGA TCTCAGGTAA TGACACACCT TCGAGTGATA 
AACGAGAGAA TGAACCAGAG CTTTTCACTC CTCTACAAGG TGCCGGCCGT GGCTGAGGAA 
ATCCAGGATG AAGTCGATGA ACTCTTCCAG AAGGAGCAGA ACTACTCAGA TGACATGGTG 
TCCAACATGG TGAGCGACCA CAGAGTCAGC TACGGGAACG ATGCCCTGAT GCCTTCTCTC 
AGCGAGACCA AGACCACCGT TGAGCTTCTT CCCGTAGATG GAGAGTTCAA CATAGAGGAC 
CTCCAGCCCT GGCATTCATT CGGGGTGGAC TCTGTTCCAG CAAACACTGA GAATGAAGTC 
GAACCAGTGG ACGCCCGCCC TGCTGCAGAT AGAGGGCTCA CTACACGCCC AGGCTCGGGA 
CTGACCAATA TCAAAACAGA AGAAATCTCA GAGGTGAAGA TGGATTCTGA ATATAGACAC 
GATACTGCCT ATGAAGTGCA CCATCAGAAA CTGGTCTTCT TCGCAGAGGA AGTGGGATCA 
AACAAAGGAG CAATCATTGG TCTGATGGTG GGGGGCGTTG TCATAGCAAC GGTGATAGTC 
ATCACTTTAG TGATGCTGAA GAAGAAGCAA TACACAACTA TCCATCATGG AGTAGTAGAG 
GTGGACGCGG CGGTGACCCC AGAAGAGCGC CACCTCACCA AGATGCAGCA GAACGGCTAC 
GAGAACCCAA CGTACAAGTT CTTCGAACAG ATGCAGAACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_018100368.1
CDS	200..2281
Translation	MLPHITLLVLTVGALALEVPADGNGGLLAEPQIAMFCGKLNMHMNVQNGKWETDVSGTKGCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKKGRKQCKSRTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDICETHLHWHTVAKESCSEKSMSLHEYGMLLPCGIDKFRGVEFVCCPSAEESESFDSADAEDDSDVWWGGADADYVDRSDDKAVEAQPDEEEEVVEVEEEETDDDEDDGDEAEEEPEEPYEEATERTTSIATTTTTTTESVEEVVRVPATAASTPDAVDKYLENPNDENEHDRFLKAKERLEGKHREKMSEVMKEWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRIALENYITALQADPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVINERMNQSFSLLYKVPAVAEEIQDEVDELFQKEQNYSDDMVSNMVSDHRVSYGNDALMPSLSETKTTVELLPVDGEFNIEDLQPWHSFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDSEYRHDTAYEVHHQKLVFFAEEVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTTIHHGVVEVDAAVTPEERHLTKMQQNGYENPTYKFFEQMQN

Target ORF information:

RefSeq Version	XM_018244879.1
Organism	Xenopus laevis(African clawed frog)
Definition	Xenopus laevis amyloid beta (A4) precursor protein L homeolog (app.L), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_018244879.1

ORF Insert Sequence:

ATGCTGCCCC ATATAACGCT GCTCGTGCTG ACTGTCGGAG CGCTAGCGCT GGAGGTGCCA 
GCAGATGGAA ATGGAGGCCT GTTGGCAGAG CCACAGATTG CCATGTTCTG TGGCAAGCTG 
AATATGCACA TGAATGTTCA GAATGGGAAA TGGGAGACTG ATGTGTCCGG GACAAAGGGC 
TGCATTGGAA CCAAGGAAGG AATCCTTCAG TACTGTCAGG AGGTATACCC AGAGCTGCAG 
ATTACCAACG TTGTTGAAGC CAACCAGCCG GTGACAATCC AGAATTGGTG CAAGAAAGGA 
CGAAAGCAGT GCAAGAGCCG CACTCACATT GTGGTTCCCT ACAGATGCTT AGTCGGGGAG 
TTTGTTAGTG ATGCGCTGCT CGTTCCAGAC AAGTGCAAGT TCCTTCATCA GGAAAGGATG 
GACATTTGTG AAACTCACCT GCACTGGCAC ACTGTGGCCA AAGAGTCCTG CAGTGAGAAG 
AGCATGAGTC TCCATGAATA CGGAATGCTC CTTCCATGTG GAATCGATAA ATTCCGGGGA 
GTGGAGTTTG TGTGCTGCCC GTCTGCCGAA GAAAGTGAAA GCTTTGACTC CGCAGATGCA 
GAGGATGATT CTGACGTCTG GTGGGGAGGT GCTGATGCCG ATTATGTGGA TAGAAGTGAT 
GACAAGGCTG TAGAAGCCCA ACCAGATGAA GAGGAGGAGG TTGTAGAGGT GGAAGAGGAG 
GAAACGGATG ATGATGAGGA CGATGGGGAT GAAGCCGAGG AAGAACCCGA GGAACCCTAT 
GAAGAAGCCA CCGAAAGAAC AACAAGTATA GCCACTACCA CCACTACTAC TACAGAGTCT 
GTGGAAGAAG TTGTAAGAGT TCCCGCCACA GCTGCCAGCA CCCCTGACGC AGTTGACAAG 
TACCTGGAGA ACCCGAATGA TGAGAACGAG CACGACCGCT TCCTGAAAGC AAAGGAGAGG 
CTGGAGGGCA AGCACCGCGA GAAGATGTCT GAGGTGATGA AGGAATGGGA AGAAGCTGAA 
CGCCAGGCAA AGAACCTTCC CAAGGCTGAC AAGAAGGCAG TAATACAGCA TTTCCAGGAG 
AAAGTGGAAT CCCTAGAACA AGAAGCTGCA AACGAAAGGC AACAACTGGT CGAGACCCAT 
ATGGCCCGAG TGGAAGCCAT GTTAAATGAT CGTCGACGAA TCGCCCTGGA GAACTACATC 
ACTGCTCTGC AAGCTGATCC TCCACGGCCC CGCCATGTGT TCAACATGCT GAAGAAGTAC 
GTGCGGGCCG AGCAGAAGGA CAGACAGCAC ACTCTCAAAC ACTTTGAGCA TGTCCGTATG 
GTAGATCCCA AGAAGGCGGC TCAAATCCGA TCTCAGGTAA TGACACACCT TCGAGTGATA 
AACGAGAGAA TGAACCAGAG CTTTTCACTC CTCTACAAGG TGCCGGCCGT GGCTGAGGAA 
ATCCAGGATG AAGTCGATGA ACTCTTCCAG AAGGAGCAGA ACTACTCAGA TGACATGGTG 
TCCAACATGG TGAGCGACCA CAGAGTCAGC TACGGGAACG ATGCCCTGAT GCCTTCTCTC 
AGCGAGACCA AGACCACCGT TGAGCTTCTT CCCGTAGATG GAGAGTTCAA CATAGAGGAC 
CTCCAGCCCT GGCATTCATT CGGGGTGGAC TCTGTTCCAG CAAACACTGA GAATGAAGTC 
GAACCAGTGG ACGCCCGCCC TGCTGCAGAT AGAGGGCTCA CTACACGCCC AGGCTCGGGA 
CTGACCAATA TCAAAACAGA AGAAATCTCA GAGGTGAAGA TGGATTCTGA ATATAGACAC 
GATACTGCCT ATGAAGTGCA CCATCAGAAA CTGGTCTTCT TCGCAGAGGA AGTGGGATCA 
AACAAAGGAG CAATCATTGG TCTGATGGTG GGGGGCGTTG TCATAGCAAC GGTGATAGTC 
ATCACTTTAG TGATGCTGAA GAAGAAGCAA TACACAACTA TCCATCATGG AGTAGTAGAG 
GTGGACGCGG CGGTGACCCC AGAAGAGCGC CACCTCACCA AGATGCAGCA GAACGGCTAC 
GAGAACCCAA CGTACAAGTT CTTCGAACAG ATGCAGAACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endogenous C-terminal fragments of beta-amyloid precursor protein from Xenopus laevis skin exudate.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology146(4)530-9(2007 Apr)
Clamagirand C,El Abida B,Der Garabedian PA,Hanquez C,Dubost L,Marie A,Rholam M,Friguet B,Cohen P

Biosynthesis and differential processing of two pools of amyloid-beta precursor protein in a physiologically inducible neuroendocrine cell.
Journal of neurochemistry94(4)1015-24(2005 Aug)
Collin RW,van den Hurk WH,Martens GJ

Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology18(11)1288-90(2004 Aug)
Maloney B,Ge YW,Greig N,Lahiri DK

Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative.
Developmental dynamics : an official publication of the American Association of Anatomists225(4)384-91(2002 Dec)
Klein SL,Strausberg RL,Wagner L,Pontius J,Clifton SW,Richardson P

Expression of the gene encoding the beta-amyloid precursor protein APP in Xenopus laevis.
Brain research. Molecular brain research97(1)13-20(2001 Dec)
van den Hurk WH,Bloemen M,Martens GJ

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app.L cDNA ORF clone, Xenopus laevis(African clawed frog)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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