Gsk3b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gsk3b
Entrez Gene ID	84027
Full Name	glycogen synthase kinase 3 beta
General protein information	Preferred Names glycogen synthase kinase 3 beta Names glycogen synthase kinase-3 beta FA GSK-3 beta factor A serine/threonine-protein kinase GSK3B
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q21
Summary	mediates Par6-atypical protein kinase C (aPKC) complex regulation of cell polarity; may induce apoptosis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_032080.1	NP_114469.1	glycogen synthase kinase-3 beta
XM_006248375.3	XP_006248437.1	glycogen synthase kinase-3 beta isoform X3
XM_006248373.3	XP_006248435.1	glycogen synthase kinase-3 beta isoform X1
XM_006248374.3	XP_006248436.1	glycogen synthase kinase-3 beta isoform X2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GSK3B	NP_001094780.1
Mus musculus (house mouse)	Gsk3b	NP_062801.1
Rattus norvegicus (Norway rat)	Gsk3b	NP_114469.1
Caenorhabditis elegans (roundworm)	gsk-3	NP_493243.1
Xenopus tropicalis (tropical clawed frog)	gsk3b	XP_002941025.2
Canis lupus familiaris (dog)	GSK3B	XP_535751.2
Danio rerio (zebrafish)	gsk3b	NP_571456.1
Pan troglodytes (chimpanzee)	GSK3B	XP_003339094.1
Homo sapiens (human)	GSK3B	NP_002084.2
Arabidopsis thaliana (thale cress)	SK13	NP_196968.2
Oryza sativa (rice)	Os05g0134000	NP_001054564.1
Gallus gallus (chicken)	GSK3B	XP_416557.4

Gene Ontology
Bibliography

Related articles in PubMed

GSK3β and MCL-1 mediate cardiomyocyte apoptosis in response to high glucose.
Su D, Zhao J, Hu S, Guan L, Li Q, Shi C, Ma X, Gou J, Zhou Y
Histochemistry and cell biology152(3)217-225(2019 Sep)

Inhibition of GSK-3β alleviates cerebral ischemia/reperfusion injury in rats by suppressing NLRP3 inflammasome activation through autophagy.
Wang Y, Meng C, Zhang J, Wu J, Zhao J
International immunopharmacology68234-241(2019 Mar)

Decrease of GSK3β Ser-9 Phosphorylation Induced Osteoblast Apoptosis in Rat Osteoarthritis Model.
Deng S, Nie ZG, Peng PJ, Liu Y, Xing S, Long LS, Peng H
Current medical science39(1)75-80(2019 Feb)

The mechanisms of glycemic variability accelerate diabetic central neuropathy and diabetic peripheral neuropathy in diabetic rats.
Yang J, Zhao Z, Yuan H, Ma X, Li Y, Wang H, Ma X, Qin G
Biochemical and biophysical research communications510(1)35-41(2019 02)

Inhibition of glycogen synthase kinase-3β is involved in cardioprotection by α7nAChR agonist and limb remote ischemic postconditionings.
Li HX, Cui XL, Xue FS, Yang GZ, Liu YY, Liu Q, Liao X
Bioscience reports38(5)(2018 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Gsk3b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gsk3b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13116	NM_032080.1 Latest version!	Rattus norvegicus glycogen synthase kinase 3 beta (Gsk3b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa34294	XM_006248373.3 Latest version!	Rattus norvegicus glycogen synthase kinase 3 beta (Gsk3b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa34295	XM_006248374.3 Latest version!	Rattus norvegicus glycogen synthase kinase 3 beta (Gsk3b), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa34296	XM_006248375.3 Latest version!	Rattus norvegicus glycogen synthase kinase 3 beta (Gsk3b), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gsk3b ( NM_032080.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_114469.1 Rattus norvegicus glycogen synthase kinase 3 beta (Gsk3b), mRNA.

Price & Availability↑

CloneID	ORa13116
Clone ID Related Accession (Same CDS sequence)	NM_032080.1
Accession Version	NM_032080.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1263bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575302400000
Organism	Rattus norvegicus(Norway rat)
Product	glycogen synthase kinase-3 beta
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X73653.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X73653.1, X53428.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCGGGGC GACCGAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT 
TCAGCTTTTG GTAGCATGAA AGTTAGCAGA GATAAAGATG GCAGCAAGGT AACCACAGTG 
GTGGCAACTC CTGGACAGGG TCCTGACAGG CCACAGGAAG TCAGTTACAC AGACACTAAA 
GTCATTGGAA ATGGGTCATT TGGTGTGGTA TATCAAGCCA AACTTTGTGA CTCAGGAGAA 
CTGGTGGCCA TCAAGAAAGT TCTTCAGGAC AAGCGATTTA AGAACCGAGA GCTCCAGATC 
ATGAGAAAGC TAGATCACTG TAACATAGTC CGATTGCGGT ATTTCTTCTA CTCGAGTGGC 
GAGAAGAAAG ATGAGGTCTA CCTTAACCTG GTGCTGGACT ATGTTCCGGA AACAGTGTAC 
AGAGTCGCCA GACACTATAG TCGAGCCAAG CAGACACTCC CTGTGATCTA TGTCAAGTTG 
TATATGTACC AGCTGTTCAG AAGTCTAGCC TATATCCATT CCTTTGGGAT CTGCCATCGA 
GACATTAAAC CACAGAACCT CTTGCTGGAT CCTGATACAG CTGTATTAAA ACTCTGCGAC 
TTTGGAAGTG CAAAGCAGCT GGTCCGAGGA GAGCCCAATG TTTCATATAT CTGTTCTCGG 
TACTACAGGG CACCAGAGCT GATCTTTGGA GCCACCGATT ACACGTCTAG TATAGATGTA 
TGGTCTGCAG GCTGTGTGTT GGCTGAATTG TTGCTAGGAC AACCAATATT TCCTGGGGAC 
AGTGGTGTGG ATCAGTTGGT GGAAATAATA AAGGTCCTAG GAACACCAAC AAGGGAGCAA 
ATTAGAGAAA TGAACCCAAA TTATACAGAA TTCAAATTCC CCCAAATCAA GGCACATCCT 
TGGACGAAGG TCTTTCGGCC CCGAACTCCA CCAGAGGCAA TCGCACTGTG TAGCCGTCTC 
CTGGAGTACA CGCCGACCGC CCGGCTAACA CCACTGGAAG CTTGTGCACA TTCATTTTTT 
GATGAATTAC GGGACCCAAA TGTCAAACTA CCAAATGGGC GAGACACACC TGCCCTCTTC 
AACTTTACCA CTCAAGAACT GTCAAGTAAC CCACCTCTGG CCACCATCCT TATCCCTCCT 
CACGCTCGGA TTCAGGCAGC TGCTTCACCG CCTGCAAACG CCACAGCAGC CTCAGATACT 
AATGCTGGAG ACCGTGGACA GACCAATAAC GCCGCTTCTG CATCAGCCTC CAACTCTACC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114469.1
CDS	140..1402
Translation	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST

Target ORF information:

RefSeq Version	NM_032080.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glycogen synthase kinase 3 beta (Gsk3b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032080.1

ORF Insert Sequence:

ATGTCGGGGC GACCGAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT 
TCAGCTTTTG GTAGCATGAA AGTTAGCAGA GATAAAGATG GCAGCAAGGT AACCACAGTG 
GTGGCAACTC CTGGACAGGG TCCTGACAGG CCACAGGAAG TCAGTTACAC AGACACTAAA 
GTCATTGGAA ATGGGTCATT TGGTGTGGTA TATCAAGCCA AACTTTGTGA CTCAGGAGAA 
CTGGTGGCCA TCAAGAAAGT TCTTCAGGAC AAGCGATTTA AGAACCGAGA GCTCCAGATC 
ATGAGAAAGC TAGATCACTG TAACATAGTC CGATTGCGGT ATTTCTTCTA CTCGAGTGGC 
GAGAAGAAAG ATGAGGTCTA CCTTAACCTG GTGCTGGACT ATGTTCCGGA AACAGTGTAC 
AGAGTCGCCA GACACTATAG TCGAGCCAAG CAGACACTCC CTGTGATCTA TGTCAAGTTG 
TATATGTACC AGCTGTTCAG AAGTCTAGCC TATATCCATT CCTTTGGGAT CTGCCATCGA 
GACATTAAAC CACAGAACCT CTTGCTGGAT CCTGATACAG CTGTATTAAA ACTCTGCGAC 
TTTGGAAGTG CAAAGCAGCT GGTCCGAGGA GAGCCCAATG TTTCATATAT CTGTTCTCGG 
TACTACAGGG CACCAGAGCT GATCTTTGGA GCCACCGATT ACACGTCTAG TATAGATGTA 
TGGTCTGCAG GCTGTGTGTT GGCTGAATTG TTGCTAGGAC AACCAATATT TCCTGGGGAC 
AGTGGTGTGG ATCAGTTGGT GGAAATAATA AAGGTCCTAG GAACACCAAC AAGGGAGCAA 
ATTAGAGAAA TGAACCCAAA TTATACAGAA TTCAAATTCC CCCAAATCAA GGCACATCCT 
TGGACGAAGG TCTTTCGGCC CCGAACTCCA CCAGAGGCAA TCGCACTGTG TAGCCGTCTC 
CTGGAGTACA CGCCGACCGC CCGGCTAACA CCACTGGAAG CTTGTGCACA TTCATTTTTT 
GATGAATTAC GGGACCCAAA TGTCAAACTA CCAAATGGGC GAGACACACC TGCCCTCTTC 
AACTTTACCA CTCAAGAACT GTCAAGTAAC CCACCTCTGG CCACCATCCT TATCCCTCCT 
CACGCTCGGA TTCAGGCAGC TGCTTCACCG CCTGCAAACG CCACAGCAGC CTCAGATACT 
AATGCTGGAG ACCGTGGACA GACCAATAAC GCCGCTTCTG CATCAGCCTC CAACTCTACC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gsk3b ( XM_006248373.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006248435.1 Rattus norvegicus glycogen synthase kinase 3 beta (Gsk3b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa34294
Clone ID Related Accession (Same CDS sequence)	XM_006248373.3
Accession Version	XM_006248373.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	glycogen synthase kinase-3 beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005110.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006248373.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGGGC GACCGAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT 
TCAGCTTTTG GTAGCATGAA AGTTAGCAGA GATAAAGATG GCAGCAAGGT AACCACAGTG 
GTGGCAACTC CTGGACAGGG TCCTGACAGG CCACAGGAAG TCAGTTACAC AGACACTAAA 
GTCATTGGAA ATGGGTCATT TGGTGTGGTA TATCAAGCCA AACTTTGTGA CTCAGGAGAA 
CTGGTGGCCA TCAAGAAAGT TCTTCAGGAC AAGCGATTTA AGAACCGAGA GCTCCAGATC 
ATGAGAAAGC TAGATCACTG TAACATAGTC CGATTGCGGT ATTTCTTCTA CTCGAGTGGC 
GAGAAGAAAG ATGAGGTCTA CCTTAACCTG GTGCTGGACT ATGTTCCGGA AACAGTGTAC 
AGAGTCGCCA GACACTATAG TCGAGCCAAG CAGACACTCC CTGTGATCTA TGTCAAGTTG 
TATATGTACC AGCTGTTCAG AAGTCTAGCC TATATCCATT CCTTTGGGAT CTGCCATCGA 
GACATTAAAC CACAGAACCT CTTGCTGGAT CCTGATACAG CTGTATTAAA ACTCTGCGAC 
TTTGGAAGTG CAAAGCAGCT GGTCCGAGGA GAGCCCAATG TTTCATATAT CTGTTCTCGG 
TACTACAGGG CACCAGAGCT GATCTTTGGA GCCACCGATT ACACGTCTAG TATAGATGTA 
TGGTCTGCAG GCTGTGTGTT GGCTGAATTG TTGCTAGGAC AACCAATATT TCCTGGGGAC 
AGTGGTGTGG ATCAGTTGGT GGAAATAATA AAGGTCCTAG GAACACCAAC AAGGGAGCAA 
ATTAGAGAAA TGAACCCAAA TTATACAGAA TTCAAATTCC CCCAAATCAA GGCACATCCT 
TGGACGAAGG ATCCATCAGG AACAGGACAT TTCACCCCAG GAGCACGGGT CTTTCGGCCC 
CGAACTCCAC CAGAGGCAAT CGCACTGTGT AGCCGTCTCC TGGAGTACAC GCCGACCGCC 
CGGCTAACAC CACTGGAAGC TTGTGCACAT TCATTTTTTG ATGAATTACG GGACCCAAAT 
GTCAAACTAC CAAATGGGCG AGACACACCT GCCCTCTTCA ACTTTACCAC TCAAGAACTG 
TCAAGTAACC CACCTCTGGC CACCATCCTT ATCCCTCCTC ACGCTCGGAT TCAGGCAGCT 
GCTTCACCTC CTGCAAACGC CACAGCAGCC TCAGATACTA ATGCTGGAGA CCGTGGACAG 
ACCAATAACG CCGCTTCTGC ATCAGCCTCC AACTCTACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006248435.1
CDS	145..1446
Translation	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKDPSGTGHFTPGARVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST

Target ORF information:

RefSeq Version	XM_006248373.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glycogen synthase kinase 3 beta (Gsk3b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006248373.3

ORF Insert Sequence:

ATGTCGGGGC GACCGAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT 
TCAGCTTTTG GTAGCATGAA AGTTAGCAGA GATAAAGATG GCAGCAAGGT AACCACAGTG 
GTGGCAACTC CTGGACAGGG TCCTGACAGG CCACAGGAAG TCAGTTACAC AGACACTAAA 
GTCATTGGAA ATGGGTCATT TGGTGTGGTA TATCAAGCCA AACTTTGTGA CTCAGGAGAA 
CTGGTGGCCA TCAAGAAAGT TCTTCAGGAC AAGCGATTTA AGAACCGAGA GCTCCAGATC 
ATGAGAAAGC TAGATCACTG TAACATAGTC CGATTGCGGT ATTTCTTCTA CTCGAGTGGC 
GAGAAGAAAG ATGAGGTCTA CCTTAACCTG GTGCTGGACT ATGTTCCGGA AACAGTGTAC 
AGAGTCGCCA GACACTATAG TCGAGCCAAG CAGACACTCC CTGTGATCTA TGTCAAGTTG 
TATATGTACC AGCTGTTCAG AAGTCTAGCC TATATCCATT CCTTTGGGAT CTGCCATCGA 
GACATTAAAC CACAGAACCT CTTGCTGGAT CCTGATACAG CTGTATTAAA ACTCTGCGAC 
TTTGGAAGTG CAAAGCAGCT GGTCCGAGGA GAGCCCAATG TTTCATATAT CTGTTCTCGG 
TACTACAGGG CACCAGAGCT GATCTTTGGA GCCACCGATT ACACGTCTAG TATAGATGTA 
TGGTCTGCAG GCTGTGTGTT GGCTGAATTG TTGCTAGGAC AACCAATATT TCCTGGGGAC 
AGTGGTGTGG ATCAGTTGGT GGAAATAATA AAGGTCCTAG GAACACCAAC AAGGGAGCAA 
ATTAGAGAAA TGAACCCAAA TTATACAGAA TTCAAATTCC CCCAAATCAA GGCACATCCT 
TGGACGAAGG ATCCATCAGG AACAGGACAT TTCACCCCAG GAGCACGGGT CTTTCGGCCC 
CGAACTCCAC CAGAGGCAAT CGCACTGTGT AGCCGTCTCC TGGAGTACAC GCCGACCGCC 
CGGCTAACAC CACTGGAAGC TTGTGCACAT TCATTTTTTG ATGAATTACG GGACCCAAAT 
GTCAAACTAC CAAATGGGCG AGACACACCT GCCCTCTTCA ACTTTACCAC TCAAGAACTG 
TCAAGTAACC CACCTCTGGC CACCATCCTT ATCCCTCCTC ACGCTCGGAT TCAGGCAGCT 
GCTTCACCTC CTGCAAACGC CACAGCAGCC TCAGATACTA ATGCTGGAGA CCGTGGACAG 
ACCAATAACG CCGCTTCTGC ATCAGCCTCC AACTCTACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gsk3b ( XM_006248374.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006248436.1 Rattus norvegicus glycogen synthase kinase 3 beta (Gsk3b), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa34295
Clone ID Related Accession (Same CDS sequence)	XM_006248374.3
Accession Version	XM_006248374.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1293bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	glycogen synthase kinase-3 beta isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005110.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006248374.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGGGC GACCGAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT 
TCAGCTTTTG GTAGCATGAA AGTTAGCAGA GATAAAGATG GCAGCAAGGT AACCACAGTG 
GTGGCAACTC CTGGACAGGG TCCTGACAGG CCACAGGAAG TCAGTTACAC AGACACTAAA 
GTCATTGGAA ATGGGTCATT TGGTGTGGTA TATCAAGCCA AACTTTGTGA CTCAGGAGAA 
CTGGTGGCCA TCAAGAAAGT TCTTCAGGAC AAGCGATTTA AGAACCGAGA GCTCCAGATC 
ATGAGAAAGC TAGATCACTG TAACATAGTC CGATTGCGGT ATTTCTTCTA CTCGAGTGGC 
GAGAAGAAAG ATGAGGTCTA CCTTAACCTG GTGCTGGACT ATGTTCCGGA AACAGTGTAC 
AGAGTCGCCA GACACTATAG TCGAGCCAAG CAGACACTCC CTGTGATCTA TGTCAAGTTG 
TATATGTACC AGCTGTTCAG AAGTCTAGCC TATATCCATT CCTTTGGGAT CTGCCATCGA 
GACATTAAAC CACAGAACCT CTTGCTGGAT CCTGATACAG CTGTATTAAA ACTCTGCGAC 
TTTGGAAGTG CAAAGCAGCT GGTCCGAGGA GAGCCCAATG TTTCATATAT CTGTTCTCGG 
TACTACAGGG CACCAGAGCT GATCTTTGGA GCCACCGATT ACACGTCTAG TATAGATGTA 
TGGTCTGCAG GCTGTGTGTT GGCTGAATTG TTGCTAGGAC AACCAATATT TCCTGGGGAC 
AGTGGTGTGG ATCAGTTGGT GGAAATAATA AAGGTCCTAG GAACACCAAC AAGGGAGCAA 
ATTAGAGAAA TGAACCCAAA TTATACAGAA TTCAAATTCC CCCAAATCAA GGCACATCCT 
TGGACGAAGG ATCCATCAGG AACAGGACAT TTCACCCCAG GAGCACGGGT CTTTCGGCCC 
CGAACTCCAC CAGAGGCAAT CGCACTGTGT AGCCGTCTCC TGGAGTACAC GCCGACCGCC 
CGGCTAACAC CACTGGAAGC TTGTGCACAT TCATTTTTTG ATGAATTACG GGACCCAAAT 
GTCAAACTAC CAAATGGGCG AGACACACCT GCCCTCTTCA ACTTTACCAC TCAAGAACTG 
TCAAGTAACC CACCTCTGGC CACCATCCTT ATCCCTCCTC ACGCTCGGAT TCAGGCAGCT 
GCTTCACCTC CTGCAAACGC CACAGCAGCC TCAGTAAGCC ACATGAGATC ATGCTCAGCC 
AACCAAACTG TTGAGGACAG CTCTCAGTAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006248436.1
CDS	145..1437
Translation	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKDPSGTGHFTPGARVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPANATAASVSHMRSCSANQTVEDSSQY

Target ORF information:

RefSeq Version	XM_006248374.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glycogen synthase kinase 3 beta (Gsk3b), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006248374.3

ORF Insert Sequence:

ATGTCGGGGC GACCGAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT 
TCAGCTTTTG GTAGCATGAA AGTTAGCAGA GATAAAGATG GCAGCAAGGT AACCACAGTG 
GTGGCAACTC CTGGACAGGG TCCTGACAGG CCACAGGAAG TCAGTTACAC AGACACTAAA 
GTCATTGGAA ATGGGTCATT TGGTGTGGTA TATCAAGCCA AACTTTGTGA CTCAGGAGAA 
CTGGTGGCCA TCAAGAAAGT TCTTCAGGAC AAGCGATTTA AGAACCGAGA GCTCCAGATC 
ATGAGAAAGC TAGATCACTG TAACATAGTC CGATTGCGGT ATTTCTTCTA CTCGAGTGGC 
GAGAAGAAAG ATGAGGTCTA CCTTAACCTG GTGCTGGACT ATGTTCCGGA AACAGTGTAC 
AGAGTCGCCA GACACTATAG TCGAGCCAAG CAGACACTCC CTGTGATCTA TGTCAAGTTG 
TATATGTACC AGCTGTTCAG AAGTCTAGCC TATATCCATT CCTTTGGGAT CTGCCATCGA 
GACATTAAAC CACAGAACCT CTTGCTGGAT CCTGATACAG CTGTATTAAA ACTCTGCGAC 
TTTGGAAGTG CAAAGCAGCT GGTCCGAGGA GAGCCCAATG TTTCATATAT CTGTTCTCGG 
TACTACAGGG CACCAGAGCT GATCTTTGGA GCCACCGATT ACACGTCTAG TATAGATGTA 
TGGTCTGCAG GCTGTGTGTT GGCTGAATTG TTGCTAGGAC AACCAATATT TCCTGGGGAC 
AGTGGTGTGG ATCAGTTGGT GGAAATAATA AAGGTCCTAG GAACACCAAC AAGGGAGCAA 
ATTAGAGAAA TGAACCCAAA TTATACAGAA TTCAAATTCC CCCAAATCAA GGCACATCCT 
TGGACGAAGG ATCCATCAGG AACAGGACAT TTCACCCCAG GAGCACGGGT CTTTCGGCCC 
CGAACTCCAC CAGAGGCAAT CGCACTGTGT AGCCGTCTCC TGGAGTACAC GCCGACCGCC 
CGGCTAACAC CACTGGAAGC TTGTGCACAT TCATTTTTTG ATGAATTACG GGACCCAAAT 
GTCAAACTAC CAAATGGGCG AGACACACCT GCCCTCTTCA ACTTTACCAC TCAAGAACTG 
TCAAGTAACC CACCTCTGGC CACCATCCTT ATCCCTCCTC ACGCTCGGAT TCAGGCAGCT 
GCTTCACCTC CTGCAAACGC CACAGCAGCC TCAGTAAGCC ACATGAGATC ATGCTCAGCC 
AACCAAACTG TTGAGGACAG CTCTCAGTAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gsk3b ( XM_006248375.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006248437.1 Rattus norvegicus glycogen synthase kinase 3 beta (Gsk3b), transcript variant X3, mRNA.

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CloneID	ORa34296
Clone ID Related Accession (Same CDS sequence)	XM_006248375.3
Accession Version	XM_006248375.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	glycogen synthase kinase-3 beta isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005110.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006248375.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGGGC GACCGAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT 
TCAGCTTTTG GTAGCATGAA AGTTAGCAGA GATAAAGATG GCAGCAAGGT AACCACAGTG 
GTGGCAACTC CTGGACAGGG TCCTGACAGG CCACAGGAAG TCAGTTACAC AGACACTAAA 
GTCATTGGAA ATGGGTCATT TGGTGTGGTA TATCAAGCCA AACTTTGTGA CTCAGGAGAA 
CTGGTGGCCA TCAAGAAAGT TCTTCAGGAC AAGCGATTTA AGAACCGAGA GCTCCAGATC 
ATGAGAAAGC TAGATCACTG TAACATAGTC CGATTGCGGT ATTTCTTCTA CTCGAGTGGC 
GAGAAGAAAG ATGAGGTCTA CCTTAACCTG GTGCTGGACT ATGTTCCGGA AACAGTGTAC 
AGAGTCGCCA GACACTATAG TCGAGCCAAG CAGACACTCC CTGTGATCTA TGTCAAGTTG 
TATATGTACC AGCTGTTCAG AAGTCTAGCC TATATCCATT CCTTTGGGAT CTGCCATCGA 
GACATTAAAC CACAGAACCT CTTGCTGGAT CCTGATACAG CTGTATTAAA ACTCTGCGAC 
TTTGGAAGTG CAAAGCAGCT GGTCCGAGGA GAGCCCAATG TTTCATATAT CTGTTCTCGG 
TACTACAGGG CACCAGAGCT GATCTTTGGA GCCACCGATT ACACGTCTAG TATAGATGTA 
TGGTCTGCAG GCTGTGTGTT GGCTGAATTG TTGCTAGGAC AACCAATATT TCCTGGGGAC 
AGTGGTGTGG ATCAGTTGGT GGAAATAATA AAGGTCCTAG GAACACCAAC AAGGGAGCAA 
ATTAGAGAAA TGAACCCAAA TTATACAGAA TTCAAATTCC CCCAAATCAA GGCACATCCT 
TGGACGAAGG ATCCATCAGG AACAGGACAT TTCACCCCAG GAGCACGGGT CTTTCGGCCC 
CGAACTCCAC CAGAGGCAAT CGCACTGTGT AGCCGTCTCC TGGAGTACAC GCCGACCGCC 
CGGCTAACAC CACTGGAAGC TTGTGCACAT TCATTTTTTG ATGAATTACG GGACCCAAAT 
GTCAAACTAC CAAATGGGCG AGACACACCT GCCCTCTTCA ACTTTACCAC TCAAGAACTG 
TCAAGTAACC CACCTCTGGC CACCATCCTT ATCCCTCCTC ACGCTCGGAT TCAGGCAGCT 
GCTTCACCTC CTGCAAACGC CACAGCAGCC TCAGATGAAC TCCACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006248437.1
CDS	145..1392
Translation	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKDPSGTGHFTPGARVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPANATAASDELH

Target ORF information:

RefSeq Version	XM_006248375.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glycogen synthase kinase 3 beta (Gsk3b), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006248375.3

ORF Insert Sequence:

ATGTCGGGGC GACCGAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT 
TCAGCTTTTG GTAGCATGAA AGTTAGCAGA GATAAAGATG GCAGCAAGGT AACCACAGTG 
GTGGCAACTC CTGGACAGGG TCCTGACAGG CCACAGGAAG TCAGTTACAC AGACACTAAA 
GTCATTGGAA ATGGGTCATT TGGTGTGGTA TATCAAGCCA AACTTTGTGA CTCAGGAGAA 
CTGGTGGCCA TCAAGAAAGT TCTTCAGGAC AAGCGATTTA AGAACCGAGA GCTCCAGATC 
ATGAGAAAGC TAGATCACTG TAACATAGTC CGATTGCGGT ATTTCTTCTA CTCGAGTGGC 
GAGAAGAAAG ATGAGGTCTA CCTTAACCTG GTGCTGGACT ATGTTCCGGA AACAGTGTAC 
AGAGTCGCCA GACACTATAG TCGAGCCAAG CAGACACTCC CTGTGATCTA TGTCAAGTTG 
TATATGTACC AGCTGTTCAG AAGTCTAGCC TATATCCATT CCTTTGGGAT CTGCCATCGA 
GACATTAAAC CACAGAACCT CTTGCTGGAT CCTGATACAG CTGTATTAAA ACTCTGCGAC 
TTTGGAAGTG CAAAGCAGCT GGTCCGAGGA GAGCCCAATG TTTCATATAT CTGTTCTCGG 
TACTACAGGG CACCAGAGCT GATCTTTGGA GCCACCGATT ACACGTCTAG TATAGATGTA 
TGGTCTGCAG GCTGTGTGTT GGCTGAATTG TTGCTAGGAC AACCAATATT TCCTGGGGAC 
AGTGGTGTGG ATCAGTTGGT GGAAATAATA AAGGTCCTAG GAACACCAAC AAGGGAGCAA 
ATTAGAGAAA TGAACCCAAA TTATACAGAA TTCAAATTCC CCCAAATCAA GGCACATCCT 
TGGACGAAGG ATCCATCAGG AACAGGACAT TTCACCCCAG GAGCACGGGT CTTTCGGCCC 
CGAACTCCAC CAGAGGCAAT CGCACTGTGT AGCCGTCTCC TGGAGTACAC GCCGACCGCC 
CGGCTAACAC CACTGGAAGC TTGTGCACAT TCATTTTTTG ATGAATTACG GGACCCAAAT 
GTCAAACTAC CAAATGGGCG AGACACACCT GCCCTCTTCA ACTTTACCAC TCAAGAACTG 
TCAAGTAACC CACCTCTGGC CACCATCCTT ATCCCTCCTC ACGCTCGGAT TCAGGCAGCT 
GCTTCACCTC CTGCAAACGC CACAGCAGCC TCAGATGAAC TCCACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GSK3β and MCL-1 mediate cardiomyocyte apoptosis in response to high glucose.
Histochemistry and cell biology152(3)217-225(2019 Sep)
Su D,Zhao J,Hu S,Guan L,Li Q,Shi C,Ma X,Gou J,Zhou Y

Inhibition of GSK-3β alleviates cerebral ischemia/reperfusion injury in rats by suppressing NLRP3 inflammasome activation through autophagy.
International immunopharmacology68234-241(2019 Mar)
Wang Y,Meng C,Zhang J,Wu J,Zhao J

Decrease of GSK3β Ser-9 Phosphorylation Induced Osteoblast Apoptosis in Rat Osteoarthritis Model.
Current medical science39(1)75-80(2019 Feb)
Deng S,Nie ZG,Peng PJ,Liu Y,Xing S,Long LS,Peng H

The mechanisms of glycemic variability accelerate diabetic central neuropathy and diabetic peripheral neuropathy in diabetic rats.
Biochemical and biophysical research communications510(1)35-41(2019 02)
Yang J,Zhao Z,Yuan H,Ma X,Li Y,Wang H,Ma X,Qin G

Inhibition of glycogen synthase kinase-3β is involved in cardioprotection by α7nAChR agonist and limb remote ischemic postconditionings.
Bioscience reports38(5)(2018 10)
Li HX,Cui XL,Xue FS,Yang GZ,Liu YY,Liu Q,Liao X

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Gsk3b cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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