Mdh2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mdh2
Entrez Gene ID	81829
Full Name	malate dehydrogenase 2
Synonyms	Mor1
General protein information	Preferred Names malate dehydrogenase 2 Names malate dehydrogenase, mitochondrial malate dehydrogenase 2, NAD (mitochondrial)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q12
Summary	catalyzes the conversion of pyruvate or oxaloacetate to malate [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031151.2	NP_112413.2	malate dehydrogenase, mitochondrial precursor

Pathways from BioSystems

Homologies

Oryza sativa (rice)	Os05g0574400	NP_001056389.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001903	XP_321163.4
Magnaporthe oryzae (rice blast fungus)	MGG_09367	XP_003720254.1
Oryza sativa (rice)	Os01g0649100	NP_001043717.1
Homo sapiens (human)	MDH2	NP_005909.2
Pan troglodytes (chimpanzee)	MDH2	XP_001156205.1
Caenorhabditis elegans (roundworm)	mdh-2	NP_498457.1
Arabidopsis thaliana (thale cress)	mMDH1	NP_564625.1
Kluyveromyces lactis	KLLA0F25960g	XP_456236.1
Macaca mulatta (Rhesus monkey)	LOC719983	XP_001114888.1
Mus musculus (house mouse)	Mdh2	NP_032643.2
Gallus gallus (chicken)	MDH2	XP_415765.1
Drosophila melanogaster (fruit fly)	Mdh2	NP_650696.1
Arabidopsis thaliana (thale cress)	mMDH2	NP_188120.1
Xenopus tropicalis (tropical clawed frog)	mdh2	NP_001011412.1
Canis lupus familiaris (dog)	LOC102152275	XP_005634130.1
Schizosaccharomyces pombe (fission yeast)	SPCC306.08c	NP_587816.1
Danio rerio (zebrafish)	mdh2	NP_998296.1
Canis lupus familiaris (dog)	MDH2	XP_849944.1
Rattus norvegicus (Norway rat)	Mdh2	NP_112413.2
Eremothecium gossypii	AGOS_ADR152C	NP_984248.1
Neurospora crassa	NCU04899	XP_958408.1
Saccharomyces cerevisiae (baker's yeast)	MDH1	NP_012838.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset Severe Encephalopathy.
Ait-El-Mkadem S, Dayem-Quere M, Gusic M, Chaussenot A, Bannwarth S, François B, Genin EC, Fragaki K, Volker-Touw CLM, Vasnier C, Serre V, van Gassen KLI, Lespinasse F, Richter S, Eisenhofer G, Rouzier C, Mochel F, De Saint-Martin A, Abi Warde MT, de Sain-van der Velde MGM, Jans JJM, Amiel J, Avsec Z, Mertes C, Haack TB, Strom T, Meitinger T, Bonnen PE, Taylor RW, Gagneur J, van Hasselt PM, Rötig A, Delahodde A, Prokisch H, Fuchs SA, Paquis-Flucklinger V
American journal of human genetics100(1)151-159(2017 Jan)

Acute administration of l-tyrosine alters energetic metabolism of hippocampus and striatum of infant rats.
Ramos AC, Ferreira GK, Carvalho-Silva M, Furlanetto CB, Gonçalves CL, Ferreira GC, Schuck PF, Streck EL
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience31(5)303-7(2013 Aug)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanhäusser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballescà JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mdh2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mdh2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12428	NM_031151.2 Latest version!	Rattus norvegicus malate dehydrogenase 2 (Mdh2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mdh2 ( NM_031151.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112413.2 Rattus norvegicus malate dehydrogenase 2 (Mdh2), mRNA.

Price & Availability↑

CloneID	ORa12428
Clone ID Related Accession (Same CDS sequence)	NM_031151.2
Accession Version	NM_031151.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569168000000
Organism	Rattus norvegicus(Norway rat)
Product	malate dehydrogenase, mitochondrial precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC063165.1. On Feb 9, 2004 this sequence version replaced NM_031151.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063165.1, FQ213887.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906348, SAMN01906349 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGCTGTCCG CTCTCGCCCG TCCTGTCGGT GCCGCTCTCC GCCGCAGCTT CAGCACTTCA 
GCCCAGAACA ATGCTAAAGT AGCTGTCCTG GGAGCTTCTG GGGGCATTGG GCAACCCCTT 
TCACTCCTCC TGAAGAACAG TCCCCTCGTG AGCCGCCTGA CCCTCTATGA CATCGCTCAC 
ACACCTGGTG TGGCAGCAGA TCTGAGTCAC ATCGAGACCA GAGCAAATGT GAAAGGCTAC 
CTCGGGCCGG AGCAGCTGCC GGACTGCCTA AAAGGTTGTG ATGTGGTGGT CATCCCAGCT 
GGAGTGCCCA GGAAGCCAGG AATGACACGA GATGACCTGT TCAACACCAA TGCTACCATT 
GTGGCCACAT TGACGGCTGC CTGTGCCCAG CACTGTCCTG AAGCCATGAT TTGCATCATT 
TCCAACCCAG TTAACTCCAC CATCCCCATC ACAGCCGAAG TTTTCAAGAA GCATGGCGTA 
TACAACCCCA ACAAGATATT CGGTGTGACA ACCCTTGACA TCGTCAGAGC AAACACATTT 
GTGGCAGAGC TAAAGGGTTT GGACCCAGCT CGAGTCAATG TGCCTGTCAT TGGTGGCCAC 
GCCGGGAAGA CGATCATCCC CCTGATCTCT CAGTGTACCC CCAAGGTTGA CTTTCCCCAA 
GACCAGCTGG CCACACTCAC CGGGAGGATC CAGGAGGCTG GCACTGAAGT CGTGAAGGCC 
AAGGCTGGAG CAGGCTCTGC CACTCTGTCC ATGGCTTATG CTGGAGCCCG CTTTGTCTTC 
TCCCTGGTGG ACGCCATGAA TGGGAAGGAA GGAGTCATCG AGTGCTCTTT TGTTCAGTCC 
AAAGAGACAG AGTGCACTTA TTTCTCTACA CCCTTGCTGT TGGGGAAAAA AGGCCTGGAG 
AAGAACCTAG GCATTGGCAA AATCACTCCT TTTGAGGAGA AAATGATTGC CGAGGCCATC 
CCTGAGCTGA AAGCCTCCAT CAAGAAAGGC GAGGACTTTG TGAAGAACAT GAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112413.2
CDS	104..1120
Translation	MLSALARPVGAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETRANVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICIISNPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLATLTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVIECSFVQSKETECTYFSTPLLLGKKGLEKNLGIGKITPFEEKMIAEAIPELKASIKKGEDFVKNMK

Target ORF information:

RefSeq Version	NM_031151.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus malate dehydrogenase 2 (Mdh2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031151.2

ORF Insert Sequence:

ATGCTGTCCG CTCTCGCCCG TCCTGTCGGT GCCGCTCTCC GCCGCAGCTT CAGCACTTCA 
GCCCAGAACA ATGCTAAAGT AGCTGTCCTG GGAGCTTCTG GGGGCATTGG GCAACCCCTT 
TCACTCCTCC TGAAGAACAG TCCCCTCGTG AGCCGCCTGA CCCTCTATGA CATCGCTCAC 
ACACCTGGTG TGGCAGCAGA TCTGAGTCAC ATCGAGACCA GAGCAAATGT GAAAGGCTAC 
CTCGGGCCGG AGCAGCTGCC GGACTGCCTA AAAGGTTGTG ATGTGGTGGT CATCCCAGCT 
GGAGTGCCCA GGAAGCCAGG AATGACACGA GATGACCTGT TCAACACCAA TGCTACCATT 
GTGGCCACAT TGACGGCTGC CTGTGCCCAG CACTGTCCTG AAGCCATGAT TTGCATCATT 
TCCAACCCAG TTAACTCCAC CATCCCCATC ACAGCCGAAG TTTTCAAGAA GCATGGCGTA 
TACAACCCCA ACAAGATATT CGGTGTGACA ACCCTTGACA TCGTCAGAGC AAACACATTT 
GTGGCAGAGC TAAAGGGTTT GGACCCAGCT CGAGTCAATG TGCCTGTCAT TGGTGGCCAC 
GCCGGGAAGA CGATCATCCC CCTGATCTCT CAGTGTACCC CCAAGGTTGA CTTTCCCCAA 
GACCAGCTGG CCACACTCAC CGGGAGGATC CAGGAGGCTG GCACTGAAGT CGTGAAGGCC 
AAGGCTGGAG CAGGCTCTGC CACTCTGTCC ATGGCTTATG CTGGAGCCCG CTTTGTCTTC 
TCCCTGGTGG ACGCCATGAA TGGGAAGGAA GGAGTCATCG AGTGCTCTTT TGTTCAGTCC 
AAAGAGACAG AGTGCACTTA TTTCTCTACA CCCTTGCTGT TGGGGAAAAA AGGCCTGGAG 
AAGAACCTAG GCATTGGCAA AATCACTCCT TTTGAGGAGA AAATGATTGC CGAGGCCATC 
CCTGAGCTGA AAGCCTCCAT CAAGAAAGGC GAGGACTTTG TGAAGAACAT GAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset Severe Encephalopathy.
American journal of human genetics100(1)151-159(2017 Jan)
Ait-El-Mkadem S,Dayem-Quere M,Gusic M,Chaussenot A,Bannwarth S,François B,Genin EC,Fragaki K,Volker-Touw CLM,Vasnier C,Serre V,van Gassen KLI,Lespinasse F,Richter S,Eisenhofer G,Rouzier C,Mochel F,De Saint-Martin A,Abi Warde MT,de Sain-van der Velde MGM,Jans JJM,Amiel J,Avsec Z,Mertes C,Haack TB,Strom T,Meitinger T,Bonnen PE,Taylor RW,Gagneur J,van Hasselt PM,Rötig A,Delahodde A,Prokisch H,Fuchs SA,Paquis-Flucklinger V

Acute administration of l-tyrosine alters energetic metabolism of hippocampus and striatum of infant rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience31(5)303-7(2013 Aug)
Ramos AC,Ferreira GK,Carvalho-Silva M,Furlanetto CB,Gonçalves CL,Ferreira GC,Schuck PF,Streck EL

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanhäusser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballescà JL,Oliva R

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Mdh2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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