Lss cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lss
Entrez Gene ID	81681
Full Name	lanosterol synthase
General protein information	Preferred Names lanosterol synthase Names lanosterol synthase 2,3-epoxysqualene--lanosterol cyclase 2,3-oxidosqualene: lanosterol cyclase OSC lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) oxidosqualene--lanosterol cyclase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12
Summary	enzyme that catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031049.1	NP_112311.1	lanosterol synthase

Pathways from BioSystems

Homologies

Kluyveromyces lactis	KLLA0B10175g	XP_451982.1
Schizosaccharomyces pombe (fission yeast)	erg7	NP_593702.2
Eremothecium gossypii	AGOS_AGR351W	NP_987017.2
Magnaporthe oryzae (rice blast fungus)	MGG_11702	XP_003710102.1
Pan troglodytes (chimpanzee)	LSS	XP_531506.3
Mus musculus (house mouse)	Lss	NP_666118.1
Homo sapiens (human)	LSS	NP_001001438.1
Macaca mulatta (Rhesus monkey)	LSS	XP_001098607.1
Danio rerio (zebrafish)	lss	NP_001077036.1
Saccharomyces cerevisiae (baker's yeast)	ERG7	NP_011939.2
Arabidopsis thaliana (thale cress)	CAS1	NP_178722.1
Canis lupus familiaris (dog)	LSS	XP_548733.4
Xenopus tropicalis (tropical clawed frog)	lss	NP_001073038.1
Oryza sativa (rice)	Os02g0139700	NP_001045848.1
Rattus norvegicus (Norway rat)	Lss	NP_112311.1
Gallus gallus (chicken)	LSS	NP_001006514.2
Neurospora crassa	NCU01119	XP_961026.1
Bos taurus (cattle)	LSS	NP_001040029.1

Gene Ontology
Bibliography

Related articles in PubMed

Lanosterol reverses protein aggregation in cataracts.
Zhao L, Chen XJ, Zhu J, Xi YB, Yang X, Hu LD, Ouyang H, Patel SH, Jin X, Lin D, Wu F, Flagg K, Cai H, Li G, Cao G, Lin Y, Chen D, Wen C, Chung C, Wang Y, Qiu A, Yeh E, Wang W, Hu X, Grob S, Abagyan R, Su Z, Tjondro HC, Zhao XJ, Luo H, Hou R, Jefferson J, Perry P, Gao W, Kozak I, Granet D, Li Y, Sun X, Wang J, Zhang L, Liu Y, Yan YB, Zhang K
Nature523(7562)607-11(2015 Jul)

Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice.
Marmugi A, Lasserre F, Beuzelin D, Ducheix S, Huc L, Polizzi A, Chetivaux M, Pineau T, Martin P, Guillou H, Mselli-Lakhal L
Toxicology325133-43(2014 Nov)

Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine.
Moessinger C, Kuerschner L, Spandl J, Shevchenko A, Thiele C
The Journal of biological chemistry286(24)21330-9(2011 Jun)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile.
Dang H, Liu Y, Pang W, Li C, Wang N, Shyy JY, Zhu Y
The Journal of biological chemistry284(10)6218-26(2009 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Lss gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lss cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07466	NM_031049.1 Latest version!	Rattus norvegicus lanosterol synthase (Lss), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lss ( NM_031049.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112311.1 Rattus norvegicus lanosterol synthase (Lss), mRNA.

Price & Availability↑

CloneID	ORa07466
Clone ID Related Accession (Same CDS sequence)	NM_031049.1
Accession Version	NM_031049.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2202bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1568908800000
Organism	Rattus norvegicus(Norway rat)
Product	lanosterol synthase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U31352.1. On Jan 12, 2005 this sequence version replaced XM_346599.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U31352.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGACCGAGG GCACGTGTCT GCGGCGTCGT GGGGGACCCT ATAAAACTGA GCCCGCCACC 
GATCTCACCC GCTGGCGGCT CCATAATGAG TTGGGTCGGC AGAGATGGAC TTATTATCAA 
GCGGAGGAGG ACCCTGGTCG AGAACAGACG GGGCTAGAGG CCCACTCTTT GGGACTGGAC 
ACAACAAGTT ATTTCAAGAA CTTACCTAAA GCTCAAACAG CCCATGAGGG GGCCCTGAAC 
GGAGTAACCT TTTATGCCAA GCTGCAGGCT GAGGATGGAC ACTGGGCTGG TGATTATGGT 
GGTCCACTCT TCCTCTTGCC AGGTCTCCTG ATTACGTGTC ACATAGCACA CATCCCCCTG 
CCGGCTGGAT ACAGAGAGGA AATGGTACGG TACTTGCGCT CAGTGCAGCT TCCCAATGGC 
GGCTGGGGCT TGCACATTGA GGACAAGTCC ACGGTGTTTG GGACTGCCCT GAGCTATGTG 
TCTCTCAGAA TCCTGGGTAT TGGACCTGAT GATCCTGACC TTGTGCGTGC TCGGAACATT 
CTTCACAAAA AAGGTGGTGC AGTGGCCATC CCTTCCTGGG GGAAGTTCTG GCTGGCTGTC 
CTGAATGTTT ACAGCTGGGA AGGAATCAAT ACCCTCTTCC CTGAGATGTG GCTGCTTCCT 
GAATGGTTTC CTGCACATCC CTCCACTCTG TGGTGTCACT GCCGGCAGGT CTATCTGCCC 
ATGAGCTACT GCTACGCCAC TCGGCTAAGT GCCTCAGAGG ACCCACTGGT TCAGAGCCTC 
CGCCAGGAAC TCTATGTGGA GGATTATGCC AGCATCGATT GGCCAGCACA GAAGAACAAC 
GTGTGCCCCG ATGACATGTA CACGCCACAC AGCTGGCTGC TGCACGTGGT ATATGGACTC 
CTCAACCTGT ATGAACGTTT CCACAGTACC AGCCTGCGGA AGTGGGCCAT CCAGTTGCTG 
TATGAACATG TCGCAGCTGA TGATCGGTTC ACGAAATGCA TCAGCATTGG CCCGATCTCA 
AAAACTGTCA ACATGCTTAT TCGTTGGTCA GTGGACGGAC CATCCTCCCC TGCCTTCCAG 
GAGCACGTCT CGAGGATCAA AGATTATCTT TGGCTGGGCC TTGACGGCAT GAAAATGCAG 
GGCACCAATG GATCACAGAC CTGGGACACT TCATTTGCTG TCCAAGCCCT GCTGGAGGCA 
GGTGCACACC GAAGACCTGA GTTTTTGCCC TGCCTGCAGA AGGCTCACGA GTTCCTGCGG 
CTTTCCCAGG TCCCAGACAA CAATCCTGAC TACCAGAAGT ATTATCGCCA TATGCACAAG 
GGTGGTTTCC CCTTCAGCAC ACTGGACTGT GGCTGGATCG TTGCTGACTG CACGGCCGAG 
GCTTTGAAGG CTGTGCTGCT CCTGCAGGAG CGGTGTCCCT CAATCACCGA GCATGTCCCC 
CGAGAGCGAC TCTACGATGC TGTGGCTGTG TTGTTGAGCA TGAGGAATTC CGATGGAGGG 
TTTGCTACCT ATGAGACTAA GCGTGGCGGG TATTTGCTGG AGCTGCTGAA CCCCTCAGAG 
GTCTTTGGAG ACATCATGAT TGACTACACG TATGTAGAGT GTACCTCCGC AGTGATGCAG 
GCCCTGAGGC ACTTCCGCGA GTACTTCCCA GACCACAGGG CTACAGAGAT CAGGGAGACC 
CTCAATCAAG GCCTGGACTT CTGCCGAAAG AAGCAGAGAG CGGATGGCTC GTGGGAGGGC 
TCCTGGGGGG TTTGCTTCAC CTATGGCACC TGGTTTGGCT TGGAAGCATT CGCTTGCATG 
GGACATATCT ACCAAAATAG GACTGCTTGT GCAGAAGTAG CTCAGGCCTG CCACTTCCTC 
CTGTCGCGGC AGATGGCGGA TGGGGGCTGG GGGGAGGACT TTGAGTCCTG TGAGCAGCGG 
CGGTACGTGC AGAGTGCCGG GTCCCAGGTC CATAGTACGT GCTGGGCCCT GCTGGGTTTG 
ATGGCTGTCA GGCATCCCGA CATCTCTGCT CAGGAGAGAG GAATCAGATG TCTGCTAGGG 
AAACAGCTCC CCAACGGAGA CTGGCCTCAG GAGAACATCT CTGGGGTCTT CAACAAGTCC 
TGTGCCATCA GCTACACAAA TTACAGAAAC ATCTTCCCCA TCTGGGCCCT GGGCCGCTTC 
TCCAGCCTGT ATCCTGACAA TACCCTTGCT GGCCACATTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112311.1
CDS	42..2243
Translation	MTEGTCLRRRGGPYKTEPATDLTRWRLHNELGRQRWTYYQAEEDPGREQTGLEAHSLGLDTTSYFKNLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPLPAGYREEMVRYLRSVQLPNGGWGLHIEDKSTVFGTALSYVSLRILGIGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVCPDDMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAIQLLYEHVAADDRFTKCISIGPISKTVNMLIRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQTWDTSFAVQALLEAGAHRRPEFLPCLQKAHEFLRLSQVPDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLLLQERCPSITEHVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALRHFREYFPDHRATEIRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHIYQNRTACAEVAQACHFLLSRQMADGGWGEDFESCEQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTNYRNIFPIWALGRFSSLYPDNTLAGHI

Target ORF information:

RefSeq Version	NM_031049.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lanosterol synthase (Lss), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031049.1

ORF Insert Sequence:

ATGACCGAGG GCACGTGTCT GCGGCGTCGT GGGGGACCCT ATAAAACTGA GCCCGCCACC 
GATCTCACCC GCTGGCGGCT CCATAATGAG TTGGGTCGGC AGAGATGGAC TTATTATCAA 
GCGGAGGAGG ACCCTGGTCG AGAACAGACG GGGCTAGAGG CCCACTCTTT GGGACTGGAC 
ACAACAAGTT ATTTCAAGAA CTTACCTAAA GCTCAAACAG CCCATGAGGG GGCCCTGAAC 
GGAGTAACCT TTTATGCCAA GCTGCAGGCT GAGGATGGAC ACTGGGCTGG TGATTATGGT 
GGTCCACTCT TCCTCTTGCC AGGTCTCCTG ATTACGTGTC ACATAGCACA CATCCCCCTG 
CCGGCTGGAT ACAGAGAGGA AATGGTACGG TACTTGCGCT CAGTGCAGCT TCCCAATGGC 
GGCTGGGGCT TGCACATTGA GGACAAGTCC ACGGTGTTTG GGACTGCCCT GAGCTATGTG 
TCTCTCAGAA TCCTGGGTAT TGGACCTGAT GATCCTGACC TTGTGCGTGC TCGGAACATT 
CTTCACAAAA AAGGTGGTGC AGTGGCCATC CCTTCCTGGG GGAAGTTCTG GCTGGCTGTC 
CTGAATGTTT ACAGCTGGGA AGGAATCAAT ACCCTCTTCC CTGAGATGTG GCTGCTTCCT 
GAATGGTTTC CTGCACATCC CTCCACTCTG TGGTGTCACT GCCGGCAGGT CTATCTGCCC 
ATGAGCTACT GCTACGCCAC TCGGCTAAGT GCCTCAGAGG ACCCACTGGT TCAGAGCCTC 
CGCCAGGAAC TCTATGTGGA GGATTATGCC AGCATCGATT GGCCAGCACA GAAGAACAAC 
GTGTGCCCCG ATGACATGTA CACGCCACAC AGCTGGCTGC TGCACGTGGT ATATGGACTC 
CTCAACCTGT ATGAACGTTT CCACAGTACC AGCCTGCGGA AGTGGGCCAT CCAGTTGCTG 
TATGAACATG TCGCAGCTGA TGATCGGTTC ACGAAATGCA TCAGCATTGG CCCGATCTCA 
AAAACTGTCA ACATGCTTAT TCGTTGGTCA GTGGACGGAC CATCCTCCCC TGCCTTCCAG 
GAGCACGTCT CGAGGATCAA AGATTATCTT TGGCTGGGCC TTGACGGCAT GAAAATGCAG 
GGCACCAATG GATCACAGAC CTGGGACACT TCATTTGCTG TCCAAGCCCT GCTGGAGGCA 
GGTGCACACC GAAGACCTGA GTTTTTGCCC TGCCTGCAGA AGGCTCACGA GTTCCTGCGG 
CTTTCCCAGG TCCCAGACAA CAATCCTGAC TACCAGAAGT ATTATCGCCA TATGCACAAG 
GGTGGTTTCC CCTTCAGCAC ACTGGACTGT GGCTGGATCG TTGCTGACTG CACGGCCGAG 
GCTTTGAAGG CTGTGCTGCT CCTGCAGGAG CGGTGTCCCT CAATCACCGA GCATGTCCCC 
CGAGAGCGAC TCTACGATGC TGTGGCTGTG TTGTTGAGCA TGAGGAATTC CGATGGAGGG 
TTTGCTACCT ATGAGACTAA GCGTGGCGGG TATTTGCTGG AGCTGCTGAA CCCCTCAGAG 
GTCTTTGGAG ACATCATGAT TGACTACACG TATGTAGAGT GTACCTCCGC AGTGATGCAG 
GCCCTGAGGC ACTTCCGCGA GTACTTCCCA GACCACAGGG CTACAGAGAT CAGGGAGACC 
CTCAATCAAG GCCTGGACTT CTGCCGAAAG AAGCAGAGAG CGGATGGCTC GTGGGAGGGC 
TCCTGGGGGG TTTGCTTCAC CTATGGCACC TGGTTTGGCT TGGAAGCATT CGCTTGCATG 
GGACATATCT ACCAAAATAG GACTGCTTGT GCAGAAGTAG CTCAGGCCTG CCACTTCCTC 
CTGTCGCGGC AGATGGCGGA TGGGGGCTGG GGGGAGGACT TTGAGTCCTG TGAGCAGCGG 
CGGTACGTGC AGAGTGCCGG GTCCCAGGTC CATAGTACGT GCTGGGCCCT GCTGGGTTTG 
ATGGCTGTCA GGCATCCCGA CATCTCTGCT CAGGAGAGAG GAATCAGATG TCTGCTAGGG 
AAACAGCTCC CCAACGGAGA CTGGCCTCAG GAGAACATCT CTGGGGTCTT CAACAAGTCC 
TGTGCCATCA GCTACACAAA TTACAGAAAC ATCTTCCCCA TCTGGGCCCT GGGCCGCTTC 
TCCAGCCTGT ATCCTGACAA TACCCTTGCT GGCCACATTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lanosterol reverses protein aggregation in cataracts.
Nature523(7562)607-11(2015 Jul)
Zhao L,Chen XJ,Zhu J,Xi YB,Yang X,Hu LD,Ouyang H,Patel SH,Jin X,Lin D,Wu F,Flagg K,Cai H,Li G,Cao G,Lin Y,Chen D,Wen C,Chung C,Wang Y,Qiu A,Yeh E,Wang W,Hu X,Grob S,Abagyan R,Su Z,Tjondro HC,Zhao XJ,Luo H,Hou R,Jefferson J,Perry P,Gao W,Kozak I,Granet D,Li Y,Sun X,Wang J,Zhang L,Liu Y,Yan YB,Zhang K

Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice.
Toxicology325133-43(2014 Nov)
Marmugi A,Lasserre F,Beuzelin D,Ducheix S,Huc L,Polizzi A,Chetivaux M,Pineau T,Martin P,Guillou H,Mselli-Lakhal L

Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine.
The Journal of biological chemistry286(24)21330-9(2011 Jun)
Moessinger C,Kuerschner L,Spandl J,Shevchenko A,Thiele C

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile.
The Journal of biological chemistry284(10)6218-26(2009 Mar)
Dang H,Liu Y,Pang W,Li C,Wang N,Shyy JY,Zhu Y

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Lss cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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