Lss cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lss
Entrez Gene ID	16987
Full Name	lanosterol synthase
Synonyms	2810025N20Rik,D10Ertd116e,Osc
General protein information	Preferred Names lanosterol synthase Names lanosterol synthase 2,3-epoxysqualene--lanosterol cyclase oxidosqualene--lanosterol cyclase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10 C1\|10 39.1 cM
Summary	This gene encodes an enzyme that catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. [provided by RefSeq, Feb 2015].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017313817.1	XP_017169306.1	lanosterol synthase isoform X3
XM_006513283.3	XP_006513346.1	lanosterol synthase isoform X1
XM_006513284.3	XP_006513347.1	lanosterol synthase isoform X2
XM_030244922.1	XP_030100782.1	lanosterol synthase isoform X3
NM_146006.2	NP_666118.1	lanosterol synthase

Pathways from BioSystems

Homologies

Kluyveromyces lactis	KLLA0B10175g	XP_451982.1
Schizosaccharomyces pombe (fission yeast)	erg7	NP_593702.2
Eremothecium gossypii	AGOS_AGR351W	NP_987017.2
Magnaporthe oryzae (rice blast fungus)	MGG_11702	XP_003710102.1
Pan troglodytes (chimpanzee)	LSS	XP_531506.3
Mus musculus (house mouse)	Lss	NP_666118.1
Homo sapiens (human)	LSS	NP_001001438.1
Macaca mulatta (Rhesus monkey)	LSS	XP_001098607.1
Danio rerio (zebrafish)	lss	NP_001077036.1
Saccharomyces cerevisiae (baker's yeast)	ERG7	NP_011939.2
Arabidopsis thaliana (thale cress)	CAS1	NP_178722.1
Canis lupus familiaris (dog)	LSS	XP_548733.4
Xenopus tropicalis (tropical clawed frog)	lss	NP_001073038.1
Oryza sativa (rice)	Os02g0139700	NP_001045848.1
Rattus norvegicus (Norway rat)	Lss	NP_112311.1
Gallus gallus (chicken)	LSS	NP_001006514.2
Neurospora crassa	NCU01119	XP_961026.1
Bos taurus (cattle)	LSS	NP_001040029.1

Gene Ontology
Bibliography

Related articles in PubMed

Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.
Kim M, Wende H, Walcher J, Kühnemund J, Cheret C, Kempa S, McShane E, Selbach M, Lewin GR, Birchmeier C
Genes & development32(9-10)645-657(2018 05)

Normalization of Hepatic Homeostasis in the
Munkacsi AB, Hammond N, Schneider RT, Senanayake DS, Higaki K, Lagutin K, Bloor SJ, Ory DS, Maue RA, Chen FW, Hernandez-Ono A, Dahlson N, Repa JJ, Ginsberg HN, Ioannou YA, Sturley SL
The Journal of biological chemistry292(11)4395-4410(2017 03)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bućan M, Murray SA
Nature537(7621)508-514(2016 09)

A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.
Şişecioğlu M, Budak H, Geffers L, Çankaya M, Çiftci M, Thaller C, Eichele G, Küfrevioğlu Öİ, Özdemir H
Journal of lipid research56(8)1551-9(2015 Aug)

Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.
Nagashima S, Yagyu H, Tozawa R, Tazoe F, Takahashi M, Kitamine T, Yamamuro D, Sakai K, Sekiya M, Okazaki H, Osuga J, Honda A, Ishibashi S
Journal of lipid research56(5)998-1005(2015 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Lss gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lss cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu44243	XM_006513283.3 Latest version!	Mus musculus lanosterol synthase (Lss), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OMu44244	XM_006513284.3 Latest version!	Mus musculus lanosterol synthase (Lss), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OMu44245	XM_017313817.1 Latest version!	Mus musculus lanosterol synthase (Lss), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OMu44245	XM_030244922.1 Latest version!	Mus musculus lanosterol synthase (Lss), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OMu12121	NM_146006.2 Latest version!	Mus musculus lanosterol synthase (Lss), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$433.30 $619.00

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lss ( XM_006513283.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006513346.1 Mus musculus lanosterol synthase (Lss), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu44243
Clone ID Related Accession (Same CDS sequence)	XM_006513283.3
Accession Version	XM_006513283.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1677bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	lanosterol synthase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006513283.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTGAGG GCACGTGTCT GCGGCGTCGT GGGGGACCCT ATAAAACTGA GCCCGCCACC 
GATCTCACCC GCTGGCGGCT CCAGAATGAG TTGGGTCGGC AGAGATGGAC TTATTATCAA 
GCGGAGGACG ACCCTGGTCG AGAGCAGACC GGGCTAGAGG CCCACTCTTT GGGACTGGAC 
ACAAGAAGTT ATTTCACGGA CTTACCAAAA GCGCAAACAG CCCATGAGGG GGCCCTGAAT 
GGAGTAACCT TTTATGCCAA GCTGCAGGCT GAGGATGGAC ACTGGGCTGG TGATTATGGT 
GGTCCGCTCT TCCTCTTGCC AGGTCTCCTG ATTACCTGTC ACATATCACA CATCTCTCTG 
CCAGCTGGAT ACAGAGAGGA GATGGTGCGG TACCTGCGGT CAGTGCAGCT CCCTGATGGC 
GGCTGGGGCT TGCACATCGA GGACAAGTCC ACAGTGTTTG GGACTGCCCT GAACTATGTG 
GCTCTCAGAA TCCTGGGTAT TGGGCCTGAT GATCCTGACC TTGTGCGCGC TCGGAACGTC 
CTTCACAAAA AAGGTGGTGC GGTGGCCATC CCTTCCTGGG GGAAGTTCTG GCTGGCTGTC 
CTGAATGTTT ATAGCTGGGA AGGACTCAAC ACCCTATTCC CTGAGATGTG GCTGTTTCCT 
GAATGGGTAC CAGCGCACCC CTCCACTCTC TGGTGTCACT GCCGGCAGGT CTATCTGCCC 
ATGAGTTACT GCTACGCCAC TCGGCTAAGT GCCTCAGAGG ACCCACTGGT TCAGAGCCTC 
CGCCAGGAAC TCTATGTGCA GGATTACGCC AGCATCGATT GGCCAGCGCA GAGGAACAAC 
GTGTCCCCCG ATGAGATGTA CACGCCACAC AGCTGGCTGC TGCATGTGGT GTATGGACTC 
CTCAACCTGT ATGAACGTTT CCATAGCACC AGCCTGCGGA AGTGGGCCGT CCAGATGCTG 
TATGAACACA TTGCAGCTGA TGACTGTTTC ACTAAGTGCA TCAGCATCGG CCCGATCTCA 
AAGACCATCA ACATGCTTGT TCGTTGGTCA GTGGATGGAC CATCCTCCCC GGCCTTCCAG 
GAGCACGTTT CTCGGATCAA AGATTACCTT TGGCTGGGCC TTGATGGCAT GAAAATGCAG 
GGCACCAATG GATCACAGAT CTGGGACACT TCATTTGCTA TCCAAGCACT GTTAGAGGCA 
GGTGCACACC ACAGACCTGA GTTTCTGCCC TGCCTGCAGA AGGCTCACGA GTTCCTGCGG 
CTTTCACAGG TTCCAGAAAA CTGTCCTGAC TATCAGAAGT ACTATCGCCA TATGCGCAAG 
GGTGGTTTCT CCTTCAGCAC ACTGGACTGT GGCTGGATCG TTGCTGACTG CACAGCCGAG 
GGTTTGAAGG CTGTGCTGCT CCTGCAGAAT CAGTGTCCGT CCATCACTGA GCATATCCCC 
CGAGAGCGGC TGTGCGATGC TGTGGATGTG TTACTGAGCT TGAGGAATGC TGATGGCGGG 
TTCGCTACCT ATGAGAAGAA GCGTGGGGGT TACTTGCTGG AGCTGCTGAA CCCCTCAGAG 
GTCTTTGGAG ACATCATGAT TGACTACACG TATGTAGAGT GTACCTCCGC TGTGATGCAG 
GCACTGAAGC ATTTCCATGA ACACTTCCCA GACTACAGGG CAGCAGAGGT CAGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006513346.1
CDS	97..1773
Translation	MTEGTCLRRRGGPYKTEPATDLTRWRLQNELGRQRWTYYQAEDDPGREQTGLEAHSLGLDTRSYFTDLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHISHISLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVSPDEMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQIWDTSFAIQALLEAGAHHRPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAEGLKAVLLLQNQCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALKHFHEHFPDYRAAEVR

Target ORF information:

RefSeq Version	XM_006513283.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus lanosterol synthase (Lss), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006513283.3

ORF Insert Sequence:

ATGACTGAGG GCACGTGTCT GCGGCGTCGT GGGGGACCCT ATAAAACTGA GCCCGCCACC 
GATCTCACCC GCTGGCGGCT CCAGAATGAG TTGGGTCGGC AGAGATGGAC TTATTATCAA 
GCGGAGGACG ACCCTGGTCG AGAGCAGACC GGGCTAGAGG CCCACTCTTT GGGACTGGAC 
ACAAGAAGTT ATTTCACGGA CTTACCAAAA GCGCAAACAG CCCATGAGGG GGCCCTGAAT 
GGAGTAACCT TTTATGCCAA GCTGCAGGCT GAGGATGGAC ACTGGGCTGG TGATTATGGT 
GGTCCGCTCT TCCTCTTGCC AGGTCTCCTG ATTACCTGTC ACATATCACA CATCTCTCTG 
CCAGCTGGAT ACAGAGAGGA GATGGTGCGG TACCTGCGGT CAGTGCAGCT CCCTGATGGC 
GGCTGGGGCT TGCACATCGA GGACAAGTCC ACAGTGTTTG GGACTGCCCT GAACTATGTG 
GCTCTCAGAA TCCTGGGTAT TGGGCCTGAT GATCCTGACC TTGTGCGCGC TCGGAACGTC 
CTTCACAAAA AAGGTGGTGC GGTGGCCATC CCTTCCTGGG GGAAGTTCTG GCTGGCTGTC 
CTGAATGTTT ATAGCTGGGA AGGACTCAAC ACCCTATTCC CTGAGATGTG GCTGTTTCCT 
GAATGGGTAC CAGCGCACCC CTCCACTCTC TGGTGTCACT GCCGGCAGGT CTATCTGCCC 
ATGAGTTACT GCTACGCCAC TCGGCTAAGT GCCTCAGAGG ACCCACTGGT TCAGAGCCTC 
CGCCAGGAAC TCTATGTGCA GGATTACGCC AGCATCGATT GGCCAGCGCA GAGGAACAAC 
GTGTCCCCCG ATGAGATGTA CACGCCACAC AGCTGGCTGC TGCATGTGGT GTATGGACTC 
CTCAACCTGT ATGAACGTTT CCATAGCACC AGCCTGCGGA AGTGGGCCGT CCAGATGCTG 
TATGAACACA TTGCAGCTGA TGACTGTTTC ACTAAGTGCA TCAGCATCGG CCCGATCTCA 
AAGACCATCA ACATGCTTGT TCGTTGGTCA GTGGATGGAC CATCCTCCCC GGCCTTCCAG 
GAGCACGTTT CTCGGATCAA AGATTACCTT TGGCTGGGCC TTGATGGCAT GAAAATGCAG 
GGCACCAATG GATCACAGAT CTGGGACACT TCATTTGCTA TCCAAGCACT GTTAGAGGCA 
GGTGCACACC ACAGACCTGA GTTTCTGCCC TGCCTGCAGA AGGCTCACGA GTTCCTGCGG 
CTTTCACAGG TTCCAGAAAA CTGTCCTGAC TATCAGAAGT ACTATCGCCA TATGCGCAAG 
GGTGGTTTCT CCTTCAGCAC ACTGGACTGT GGCTGGATCG TTGCTGACTG CACAGCCGAG 
GGTTTGAAGG CTGTGCTGCT CCTGCAGAAT CAGTGTCCGT CCATCACTGA GCATATCCCC 
CGAGAGCGGC TGTGCGATGC TGTGGATGTG TTACTGAGCT TGAGGAATGC TGATGGCGGG 
TTCGCTACCT ATGAGAAGAA GCGTGGGGGT TACTTGCTGG AGCTGCTGAA CCCCTCAGAG 
GTCTTTGGAG ACATCATGAT TGACTACACG TATGTAGAGT GTACCTCCGC TGTGATGCAG 
GCACTGAAGC ATTTCCATGA ACACTTCCCA GACTACAGGG CAGCAGAGGT CAGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lss ( XM_006513284.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006513347.1 Mus musculus lanosterol synthase (Lss), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu44244
Clone ID Related Accession (Same CDS sequence)	XM_006513284.3
Accession Version	XM_006513284.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1632bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	lanosterol synthase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006513284.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTGAGG GCACGTGTCT GCGGCGTCGT GGGGGACCCT ATAAAACTGA GCCCGCCACC 
GATCTCACCC GCTGGCGGCT CCAGAATGAG TTGGGTCGGC AGAGATGGAC TTATTATCAA 
GCGGAGGACG ACCCTGGTCG AGAGCAGACC GGGCTAGAGG CCCACTCTTT GGGACTGGAC 
ACAAGAAGTT ATTTCACGGA CTTACCAAAA GCGCAAACAG CCCATGAGGG GGCCCTGAAT 
GGAGTAACCT TTTATGCCAA GCTGCAGGCT GAGGATGGAC ACTGGGCTGG TGATTATGGT 
GGTCCGCTCT TCCTCTTGCC AGGTCTCCTG ATTACCTGTC ACATATCACA CATCTCTCTG 
CCAGCTGGAT ACAGAGAGGA GATGGTGCGG TACCTGCGGT CAGTGCAGCT CCCTGATGGC 
GGCTGGGGCT TGCACATCGA GGACAAGTCC ACAGTGTTTG GGACTGCCCT GAACTATGTG 
GCTCTCAGAA TCCTGGGTAT TGGGCCTGAT GATCCTGACC TTGTGCGCGC TCGGAACGTC 
CTTCACAAAA AAGGTGGTGC GGTGGCCATC CCTTCCTGGG GGAAGTTCTG GCTGGCTGTC 
CTGAATGTTT ATAGCTGGGA AGGACTCAAC ACCCTATTCC CTGAGATGTG GCTGTTTCCT 
GAATGGGTAC CAGCGCACCC CTCCACTCTC TGGTGTCACT GCCGGCAGGT CTATCTGCCC 
ATGAGTTACT GCTACGCCAC TCGGCTAAGT GCCTCAGAGG ACCCACTGGT TCAGAGCCTC 
CGCCAGGAAC TCTATGTGCA GGATTACGCC AGCATCGATT GGCCAGCGCA GAGGAACAAC 
GTGTCCCCCG ATGAGATGTA CACGCCACAC AGCTGGCTGC TGCATGTGGT GTATGGACTC 
CTCAACCTGT ATGAACGTTT CCATAGCACC AGCCTGCGGA AGTGGGCCGT CCAGATGCTG 
TATGAACACA TTGCAGCTGA TGACTGTTTC ACTAAGTGCA TCAGCATCGG CCCGATCTCA 
AAGACCATCA ACATGCTTGT TCGTTGGTCA GTGGATGGAC CATCCTCCCC GGCCTTCCAG 
GAGCACGTTT CTCGGATCAA AGATTACCTT TGGCTGGGCC TTGATGGCAT GAAAATGCAG 
GGCACCAATG GATCACAGAT CTGGGACACT TCATTTGCTA TCCAAGCACT GTTAGAGGCA 
GGTGCACACC ACAGACCTGA GTTTCTGCCC TGCCTGCAGA AGGCTCACGA GTTCCTGCGG 
CTTTCACAGG TTCCAGAAAA CTGTCCTGAC TATCAGAAGT ACTATCGCCA TATGCGCAAG 
GGTGGTTTCT CCTTCAGCAC ACTGGACTGT GGCTGGATCG TTGCTGACTG CACAGCCGAG 
GGTTTGAAGG CTGTGCTGCT CCTGCAGAAT CAGTGTCCGT CCATCACTGA GCATATCCCC 
CGAGAGCGGC TGTGCGATGC TGTGGATGTG TTACTGAGCT TGAGGAATGC TGATGGCGGG 
TTCGCTACCT ATGAGAAGAA GCGTGGGGGT TACTTGCTGG AGCTGCTGAA CCCCTCAGAG 
GTCTTTGGGC CTCATGCTGT GTGGAGATTG CCATGTGCCC TTCATATGCT CAGTGACCCC 
CAGCACGTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006513347.1
CDS	97..1728
Translation	MTEGTCLRRRGGPYKTEPATDLTRWRLQNELGRQRWTYYQAEDDPGREQTGLEAHSLGLDTRSYFTDLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHISHISLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVSPDEMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQIWDTSFAIQALLEAGAHHRPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAEGLKAVLLLQNQCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGPHAVWRLPCALHMLSDPQHV

Target ORF information:

RefSeq Version	XM_006513284.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus lanosterol synthase (Lss), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006513284.3

ORF Insert Sequence:

ATGACTGAGG GCACGTGTCT GCGGCGTCGT GGGGGACCCT ATAAAACTGA GCCCGCCACC 
GATCTCACCC GCTGGCGGCT CCAGAATGAG TTGGGTCGGC AGAGATGGAC TTATTATCAA 
GCGGAGGACG ACCCTGGTCG AGAGCAGACC GGGCTAGAGG CCCACTCTTT GGGACTGGAC 
ACAAGAAGTT ATTTCACGGA CTTACCAAAA GCGCAAACAG CCCATGAGGG GGCCCTGAAT 
GGAGTAACCT TTTATGCCAA GCTGCAGGCT GAGGATGGAC ACTGGGCTGG TGATTATGGT 
GGTCCGCTCT TCCTCTTGCC AGGTCTCCTG ATTACCTGTC ACATATCACA CATCTCTCTG 
CCAGCTGGAT ACAGAGAGGA GATGGTGCGG TACCTGCGGT CAGTGCAGCT CCCTGATGGC 
GGCTGGGGCT TGCACATCGA GGACAAGTCC ACAGTGTTTG GGACTGCCCT GAACTATGTG 
GCTCTCAGAA TCCTGGGTAT TGGGCCTGAT GATCCTGACC TTGTGCGCGC TCGGAACGTC 
CTTCACAAAA AAGGTGGTGC GGTGGCCATC CCTTCCTGGG GGAAGTTCTG GCTGGCTGTC 
CTGAATGTTT ATAGCTGGGA AGGACTCAAC ACCCTATTCC CTGAGATGTG GCTGTTTCCT 
GAATGGGTAC CAGCGCACCC CTCCACTCTC TGGTGTCACT GCCGGCAGGT CTATCTGCCC 
ATGAGTTACT GCTACGCCAC TCGGCTAAGT GCCTCAGAGG ACCCACTGGT TCAGAGCCTC 
CGCCAGGAAC TCTATGTGCA GGATTACGCC AGCATCGATT GGCCAGCGCA GAGGAACAAC 
GTGTCCCCCG ATGAGATGTA CACGCCACAC AGCTGGCTGC TGCATGTGGT GTATGGACTC 
CTCAACCTGT ATGAACGTTT CCATAGCACC AGCCTGCGGA AGTGGGCCGT CCAGATGCTG 
TATGAACACA TTGCAGCTGA TGACTGTTTC ACTAAGTGCA TCAGCATCGG CCCGATCTCA 
AAGACCATCA ACATGCTTGT TCGTTGGTCA GTGGATGGAC CATCCTCCCC GGCCTTCCAG 
GAGCACGTTT CTCGGATCAA AGATTACCTT TGGCTGGGCC TTGATGGCAT GAAAATGCAG 
GGCACCAATG GATCACAGAT CTGGGACACT TCATTTGCTA TCCAAGCACT GTTAGAGGCA 
GGTGCACACC ACAGACCTGA GTTTCTGCCC TGCCTGCAGA AGGCTCACGA GTTCCTGCGG 
CTTTCACAGG TTCCAGAAAA CTGTCCTGAC TATCAGAAGT ACTATCGCCA TATGCGCAAG 
GGTGGTTTCT CCTTCAGCAC ACTGGACTGT GGCTGGATCG TTGCTGACTG CACAGCCGAG 
GGTTTGAAGG CTGTGCTGCT CCTGCAGAAT CAGTGTCCGT CCATCACTGA GCATATCCCC 
CGAGAGCGGC TGTGCGATGC TGTGGATGTG TTACTGAGCT TGAGGAATGC TGATGGCGGG 
TTCGCTACCT ATGAGAAGAA GCGTGGGGGT TACTTGCTGG AGCTGCTGAA CCCCTCAGAG 
GTCTTTGGGC CTCATGCTGT GTGGAGATTG CCATGTGCCC TTCATATGCT CAGTGACCCC 
CAGCACGTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lss ( XM_017313817.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017169306.1 Mus musculus lanosterol synthase (Lss), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OMu44245
Clone ID Related Accession (Same CDS sequence)	XM_017313817.1 , XM_030244922.1
Accession Version	XM_017313817.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1557bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1466438400000
Organism	Mus musculus(house mouse)
Product	lanosterol synthase isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCTGT TTCCTGAATG GGTACCAGCG CACCCCTCCA CTCTCTGGTG TCACTGCCGG 
CAGGTCTATC TGCCCATGAG TTACTGCTAC GCCACTCGGC TAAGTGCCTC AGAGGACCCA 
CTGGTTCAGA GCCTCCGCCA GGAACTCTAT GTGCAGGATT ACGCCAGCAT CGATTGGCCA 
GCGCAGAGGA ACAACGTGTC CCCCGATGAG ATGTACACGC CACACAGCTG GCTGCTGCAT 
GTGGTGTATG GACTCCTCAA CCTGTATGAA CGTTTCCATA GCACCAGCCT GCGGAAGTGG 
GCCGTCCAGA TGCTGTATGA ACACATTGCA GCTGATGACT GTTTCACTAA GTGCATCAGC 
ATCGGCCCGA TCTCAAAGAC CATCAACATG CTTGTTCGTT GGTCAGTGGA TGGACCATCC 
TCCCCGGCCT TCCAGGAGCA CGTTTCTCGG ATCAAAGATT ACCTTTGGCT GGGCCTTGAT 
GGCATGAAAA TGCAGGGCAC CAATGGATCA CAGATCTGGG ACACTTCATT TGCTATCCAA 
GCACTGTTAG AGGCAGGTGC ACACCACAGA CCTGAGTTTC TGCCCTGCCT GCAGAAGGCT 
CACGAGTTCC TGCGGCTTTC ACAGGTTCCA GAAAACTGTC CTGACTATCA GAAGTACTAT 
CGCCATATGC GCAAGGGTGG TTTCTCCTTC AGCACACTGG ACTGTGGCTG GATCGTTGCT 
GACTGCACAG CCGAGGGTTT GAAGGCTGTG CTGCTCCTGC AGAATCAGTG TCCGTCCATC 
ACTGAGCATA TCCCCCGAGA GCGGCTGTGC GATGCTGTGG ATGTGTTACT GAGCTTGAGG 
AATGCTGATG GCGGGTTCGC TACCTATGAG AAGAAGCGTG GGGGTTACTT GCTGGAGCTG 
CTGAACCCCT CAGAGGTCTT TGGAGACATC ATGATTGACT ACACGTATGT AGAGTGTACC 
TCCGCTGTGA TGCAGGCACT GAAGCATTTC CATGAACACT TCCCAGACTA CAGGGCAGCA 
GAGGTCAGGG AGACCCTCAA TCAAGGCCTG GACTTCTGCC GAAGGAAGCA GAGAGCCGAT 
GGCTCCTGGG AGGGCTCCTG GGGTGTTTGT TTCACCTACG GCACCTGGTT TGGCTTGGAA 
GCGTTCGCTT GCATGGGGCA TACCTACCAA GATGGGGCTG CTTGTGCAGA AGTAGCTCAG 
GCCTGCAACT TCCTCCTGTC CCAGCAGATG GCGGATGGAG GCTGGGGAGA GGACTTTGAA 
TCATGTGAAC AGCGGCGGTA TGTGCAGAGT GCTAGGTCCC AGGTCCATAG CACCTGCTGG 
GCCCTGATGG GTTTGATGGC TGTCAGGCAT CCCGACATCA CTGCTCAGGA GAGAGGGATC 
AGATGTCTGC TAGGGAAGCA GTTACCCAAT GGAGACTGGC CTCAGGAGAA CATCTCTGGG 
GTCTTCAACA AGTCCTGTGC CATCAGCTAC ACAAGTTACA GAAACATCTT CCCCATCTGG 
GCCCTGGGCC GCTTCTCCAA CCTGTATCCT GACAATACCC TCGCCGGCCA CATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017169306.1
CDS	277..1833
Translation	MWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVSPDEMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQIWDTSFAIQALLEAGAHHRPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAEGLKAVLLLQNQCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALKHFHEHFPDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAACAEVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTSYRNIFPIWALGRFSNLYPDNTLAGHI

Target ORF information:

RefSeq Version	XM_017313817.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus lanosterol synthase (Lss), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017313817.1

ORF Insert Sequence:

ATGTGGCTGT TTCCTGAATG GGTACCAGCG CACCCCTCCA CTCTCTGGTG TCACTGCCGG 
CAGGTCTATC TGCCCATGAG TTACTGCTAC GCCACTCGGC TAAGTGCCTC AGAGGACCCA 
CTGGTTCAGA GCCTCCGCCA GGAACTCTAT GTGCAGGATT ACGCCAGCAT CGATTGGCCA 
GCGCAGAGGA ACAACGTGTC CCCCGATGAG ATGTACACGC CACACAGCTG GCTGCTGCAT 
GTGGTGTATG GACTCCTCAA CCTGTATGAA CGTTTCCATA GCACCAGCCT GCGGAAGTGG 
GCCGTCCAGA TGCTGTATGA ACACATTGCA GCTGATGACT GTTTCACTAA GTGCATCAGC 
ATCGGCCCGA TCTCAAAGAC CATCAACATG CTTGTTCGTT GGTCAGTGGA TGGACCATCC 
TCCCCGGCCT TCCAGGAGCA CGTTTCTCGG ATCAAAGATT ACCTTTGGCT GGGCCTTGAT 
GGCATGAAAA TGCAGGGCAC CAATGGATCA CAGATCTGGG ACACTTCATT TGCTATCCAA 
GCACTGTTAG AGGCAGGTGC ACACCACAGA CCTGAGTTTC TGCCCTGCCT GCAGAAGGCT 
CACGAGTTCC TGCGGCTTTC ACAGGTTCCA GAAAACTGTC CTGACTATCA GAAGTACTAT 
CGCCATATGC GCAAGGGTGG TTTCTCCTTC AGCACACTGG ACTGTGGCTG GATCGTTGCT 
GACTGCACAG CCGAGGGTTT GAAGGCTGTG CTGCTCCTGC AGAATCAGTG TCCGTCCATC 
ACTGAGCATA TCCCCCGAGA GCGGCTGTGC GATGCTGTGG ATGTGTTACT GAGCTTGAGG 
AATGCTGATG GCGGGTTCGC TACCTATGAG AAGAAGCGTG GGGGTTACTT GCTGGAGCTG 
CTGAACCCCT CAGAGGTCTT TGGAGACATC ATGATTGACT ACACGTATGT AGAGTGTACC 
TCCGCTGTGA TGCAGGCACT GAAGCATTTC CATGAACACT TCCCAGACTA CAGGGCAGCA 
GAGGTCAGGG AGACCCTCAA TCAAGGCCTG GACTTCTGCC GAAGGAAGCA GAGAGCCGAT 
GGCTCCTGGG AGGGCTCCTG GGGTGTTTGT TTCACCTACG GCACCTGGTT TGGCTTGGAA 
GCGTTCGCTT GCATGGGGCA TACCTACCAA GATGGGGCTG CTTGTGCAGA AGTAGCTCAG 
GCCTGCAACT TCCTCCTGTC CCAGCAGATG GCGGATGGAG GCTGGGGAGA GGACTTTGAA 
TCATGTGAAC AGCGGCGGTA TGTGCAGAGT GCTAGGTCCC AGGTCCATAG CACCTGCTGG 
GCCCTGATGG GTTTGATGGC TGTCAGGCAT CCCGACATCA CTGCTCAGGA GAGAGGGATC 
AGATGTCTGC TAGGGAAGCA GTTACCCAAT GGAGACTGGC CTCAGGAGAA CATCTCTGGG 
GTCTTCAACA AGTCCTGTGC CATCAGCTAC ACAAGTTACA GAAACATCTT CCCCATCTGG 
GCCCTGGGCC GCTTCTCCAA CCTGTATCCT GACAATACCC TCGCCGGCCA CATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lss ( XM_030244922.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030100782.1 Mus musculus lanosterol synthase (Lss), transcript variant X3, mRNA.

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CloneID	OMu44245
Clone ID Related Accession (Same CDS sequence)	XM_017313817.1 , XM_030244922.1
Accession Version	XM_030244922.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1557bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	lanosterol synthase isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCTGT TTCCTGAATG GGTACCAGCG CACCCCTCCA CTCTCTGGTG TCACTGCCGG 
CAGGTCTATC TGCCCATGAG TTACTGCTAC GCCACTCGGC TAAGTGCCTC AGAGGACCCA 
CTGGTTCAGA GCCTCCGCCA GGAACTCTAT GTGCAGGATT ACGCCAGCAT CGATTGGCCA 
GCGCAGAGGA ACAACGTGTC CCCCGATGAG ATGTACACGC CACACAGCTG GCTGCTGCAT 
GTGGTGTATG GACTCCTCAA CCTGTATGAA CGTTTCCATA GCACCAGCCT GCGGAAGTGG 
GCCGTCCAGA TGCTGTATGA ACACATTGCA GCTGATGACT GTTTCACTAA GTGCATCAGC 
ATCGGCCCGA TCTCAAAGAC CATCAACATG CTTGTTCGTT GGTCAGTGGA TGGACCATCC 
TCCCCGGCCT TCCAGGAGCA CGTTTCTCGG ATCAAAGATT ACCTTTGGCT GGGCCTTGAT 
GGCATGAAAA TGCAGGGCAC CAATGGATCA CAGATCTGGG ACACTTCATT TGCTATCCAA 
GCACTGTTAG AGGCAGGTGC ACACCACAGA CCTGAGTTTC TGCCCTGCCT GCAGAAGGCT 
CACGAGTTCC TGCGGCTTTC ACAGGTTCCA GAAAACTGTC CTGACTATCA GAAGTACTAT 
CGCCATATGC GCAAGGGTGG TTTCTCCTTC AGCACACTGG ACTGTGGCTG GATCGTTGCT 
GACTGCACAG CCGAGGGTTT GAAGGCTGTG CTGCTCCTGC AGAATCAGTG TCCGTCCATC 
ACTGAGCATA TCCCCCGAGA GCGGCTGTGC GATGCTGTGG ATGTGTTACT GAGCTTGAGG 
AATGCTGATG GCGGGTTCGC TACCTATGAG AAGAAGCGTG GGGGTTACTT GCTGGAGCTG 
CTGAACCCCT CAGAGGTCTT TGGAGACATC ATGATTGACT ACACGTATGT AGAGTGTACC 
TCCGCTGTGA TGCAGGCACT GAAGCATTTC CATGAACACT TCCCAGACTA CAGGGCAGCA 
GAGGTCAGGG AGACCCTCAA TCAAGGCCTG GACTTCTGCC GAAGGAAGCA GAGAGCCGAT 
GGCTCCTGGG AGGGCTCCTG GGGTGTTTGT TTCACCTACG GCACCTGGTT TGGCTTGGAA 
GCGTTCGCTT GCATGGGGCA TACCTACCAA GATGGGGCTG CTTGTGCAGA AGTAGCTCAG 
GCCTGCAACT TCCTCCTGTC CCAGCAGATG GCGGATGGAG GCTGGGGAGA GGACTTTGAA 
TCATGTGAAC AGCGGCGGTA TGTGCAGAGT GCTAGGTCCC AGGTCCATAG CACCTGCTGG 
GCCCTGATGG GTTTGATGGC TGTCAGGCAT CCCGACATCA CTGCTCAGGA GAGAGGGATC 
AGATGTCTGC TAGGGAAGCA GTTACCCAAT GGAGACTGGC CTCAGGAGAA CATCTCTGGG 
GTCTTCAACA AGTCCTGTGC CATCAGCTAC ACAAGTTACA GAAACATCTT CCCCATCTGG 
GCCCTGGGCC GCTTCTCCAA CCTGTATCCT GACAATACCC TCGCCGGCCA CATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030100782.1
CDS	777..2333
Translation	MWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVSPDEMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQIWDTSFAIQALLEAGAHHRPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAEGLKAVLLLQNQCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALKHFHEHFPDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAACAEVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTSYRNIFPIWALGRFSNLYPDNTLAGHI

Target ORF information:

RefSeq Version	XM_030244922.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus lanosterol synthase (Lss), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030244922.1

ORF Insert Sequence:

ATGTGGCTGT TTCCTGAATG GGTACCAGCG CACCCCTCCA CTCTCTGGTG TCACTGCCGG 
CAGGTCTATC TGCCCATGAG TTACTGCTAC GCCACTCGGC TAAGTGCCTC AGAGGACCCA 
CTGGTTCAGA GCCTCCGCCA GGAACTCTAT GTGCAGGATT ACGCCAGCAT CGATTGGCCA 
GCGCAGAGGA ACAACGTGTC CCCCGATGAG ATGTACACGC CACACAGCTG GCTGCTGCAT 
GTGGTGTATG GACTCCTCAA CCTGTATGAA CGTTTCCATA GCACCAGCCT GCGGAAGTGG 
GCCGTCCAGA TGCTGTATGA ACACATTGCA GCTGATGACT GTTTCACTAA GTGCATCAGC 
ATCGGCCCGA TCTCAAAGAC CATCAACATG CTTGTTCGTT GGTCAGTGGA TGGACCATCC 
TCCCCGGCCT TCCAGGAGCA CGTTTCTCGG ATCAAAGATT ACCTTTGGCT GGGCCTTGAT 
GGCATGAAAA TGCAGGGCAC CAATGGATCA CAGATCTGGG ACACTTCATT TGCTATCCAA 
GCACTGTTAG AGGCAGGTGC ACACCACAGA CCTGAGTTTC TGCCCTGCCT GCAGAAGGCT 
CACGAGTTCC TGCGGCTTTC ACAGGTTCCA GAAAACTGTC CTGACTATCA GAAGTACTAT 
CGCCATATGC GCAAGGGTGG TTTCTCCTTC AGCACACTGG ACTGTGGCTG GATCGTTGCT 
GACTGCACAG CCGAGGGTTT GAAGGCTGTG CTGCTCCTGC AGAATCAGTG TCCGTCCATC 
ACTGAGCATA TCCCCCGAGA GCGGCTGTGC GATGCTGTGG ATGTGTTACT GAGCTTGAGG 
AATGCTGATG GCGGGTTCGC TACCTATGAG AAGAAGCGTG GGGGTTACTT GCTGGAGCTG 
CTGAACCCCT CAGAGGTCTT TGGAGACATC ATGATTGACT ACACGTATGT AGAGTGTACC 
TCCGCTGTGA TGCAGGCACT GAAGCATTTC CATGAACACT TCCCAGACTA CAGGGCAGCA 
GAGGTCAGGG AGACCCTCAA TCAAGGCCTG GACTTCTGCC GAAGGAAGCA GAGAGCCGAT 
GGCTCCTGGG AGGGCTCCTG GGGTGTTTGT TTCACCTACG GCACCTGGTT TGGCTTGGAA 
GCGTTCGCTT GCATGGGGCA TACCTACCAA GATGGGGCTG CTTGTGCAGA AGTAGCTCAG 
GCCTGCAACT TCCTCCTGTC CCAGCAGATG GCGGATGGAG GCTGGGGAGA GGACTTTGAA 
TCATGTGAAC AGCGGCGGTA TGTGCAGAGT GCTAGGTCCC AGGTCCATAG CACCTGCTGG 
GCCCTGATGG GTTTGATGGC TGTCAGGCAT CCCGACATCA CTGCTCAGGA GAGAGGGATC 
AGATGTCTGC TAGGGAAGCA GTTACCCAAT GGAGACTGGC CTCAGGAGAA CATCTCTGGG 
GTCTTCAACA AGTCCTGTGC CATCAGCTAC ACAAGTTACA GAAACATCTT CCCCATCTGG 
GCCCTGGGCC GCTTCTCCAA CCTGTATCCT GACAATACCC TCGCCGGCCA CATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lss ( NM_146006.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_666118.1 Mus musculus lanosterol synthase (Lss), mRNA.

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CloneID	OMu12121
Clone ID Related Accession (Same CDS sequence)	NM_146006.2
Accession Version	NM_146006.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2202bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1562256000000
Organism	Mus musculus(house mouse)
Product	lanosterol synthase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CJ128932.1, AK141216.1, AK031271.1, AK078023.1, AK147680.1, AK014742.1 and BY474863.1. On Feb 11, 2015 this sequence version replaced NM_146006.1. ##Evidence-Data-START## Transcript exon combination :: AK031271.1, AK154520.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTGAGG GCACGTGTCT GCGGCGTCGT GGGGGACCCT ATAAAACTGA GCCCGCCACC 
GATCTCACCC GCTGGCGGCT CCAGAATGAG TTGGGTCGGC AGAGATGGAC TTATTATCAA 
GCGGAGGACG ACCCTGGTCG AGAGCAGACC GGGCTAGAGG CCCACTCTTT GGGACTGGAC 
ACAAGAAGTT ATTTCACGGA CTTACCAAAA GCGCAAACAG CCCATGAGGG GGCCCTGAAT 
GGAGTAACCT TTTATGCCAA GCTGCAGGCT GAGGATGGAC ACTGGGCTGG TGATTATGGT 
GGTCCGCTCT TCCTCTTGCC AGGTCTCCTG ATTACCTGTC ACATATCACA CATCTCTCTG 
CCAGCTGGAT ACAGAGAGGA GATGGTGCGG TACCTGCGGT CAGTGCAGCT CCCTGATGGC 
GGCTGGGGCT TGCACATCGA GGACAAGTCC ACAGTGTTTG GGACTGCCCT GAACTATGTG 
GCTCTCAGAA TCCTGGGTAT TGGGCCTGAT GATCCTGACC TTGTGCGCGC TCGGAACGTC 
CTTCACAAAA AAGGTGGTGC GGTGGCCATC CCTTCCTGGG GGAAGTTCTG GCTGGCTGTC 
CTGAATGTTT ATAGCTGGGA AGGACTCAAC ACCCTATTCC CTGAGATGTG GCTGTTTCCT 
GAATGGGTAC CAGCGCACCC CTCCACTCTC TGGTGTCACT GCCGGCAGGT CTATCTGCCC 
ATGAGTTACT GCTACGCCAC TCGGCTAAGT GCCTCAGAGG ACCCACTGGT TCAGAGCCTC 
CGCCAGGAAC TCTATGTGCA GGATTACGCC AGCATCGATT GGCCAGCGCA GAGGAACAAC 
GTGTCCCCCG ATGAGATGTA CACGCCACAC AGCTGGCTGC TGCATGTGGT GTATGGACTC 
CTCAACCTGT ATGAACGTTT CCATAGCACC AGCCTGCGGA AGTGGGCCGT CCAGATGCTG 
TATGAACACA TTGCAGCTGA TGACTGTTTC ACTAAGTGCA TCAGCATCGG CCCGATCTCA 
AAGACCATCA ACATGCTTGT TCGTTGGTCA GTGGATGGAC CATCCTCCCC GGCCTTCCAG 
GAGCACGTTT CTCGGATCAA AGATTACCTT TGGCTGGGCC TTGATGGCAT GAAAATGCAG 
GGCACCAATG GATCACAGAT CTGGGACACT TCATTTGCTA TCCAAGCACT GTTAGAGGCA 
GGTGCACACC ACAGACCTGA GTTTCTGCCC TGCCTGCAGA AGGCTCACGA GTTCCTGCGG 
CTTTCACAGG TTCCAGAAAA CTGTCCTGAC TATCAGAAGT ACTATCGCCA TATGCGCAAG 
GGTGGTTTCT CCTTCAGCAC ACTGGACTGT GGCTGGATCG TTGCTGACTG CACAGCCGAG 
GGTTTGAAGG CTGTGCTGCT CCTGCAGAAT CAGTGTCCGT CCATCACTGA GCATATCCCC 
CGAGAGCGGC TGTGCGATGC TGTGGATGTG TTACTGAGCT TGAGGAATGC TGATGGCGGG 
TTCGCTACCT ATGAGAAGAA GCGTGGGGGT TACTTGCTGG AGCTGCTGAA CCCCTCAGAG 
GTCTTTGGAG ACATCATGAT TGACTACACG TATGTAGAGT GTACCTCCGC TGTGATGCAG 
GCACTGAAGC ATTTCCATGA ACACTTCCCA GACTACAGGG CAGCAGAGGT CAGGGAGACC 
CTCAATCAAG GCCTGGACTT CTGCCGAAGG AAGCAGAGAG CCGATGGCTC CTGGGAGGGC 
TCCTGGGGTG TTTGTTTCAC CTACGGCACC TGGTTTGGCT TGGAAGCGTT CGCTTGCATG 
GGGCATACCT ACCAAGATGG GGCTGCTTGT GCAGAAGTAG CTCAGGCCTG CAACTTCCTC 
CTGTCCCAGC AGATGGCGGA TGGAGGCTGG GGAGAGGACT TTGAATCATG TGAACAGCGG 
CGGTATGTGC AGAGTGCTAG GTCCCAGGTC CATAGCACCT GCTGGGCCCT GATGGGTTTG 
ATGGCTGTCA GGCATCCCGA CATCACTGCT CAGGAGAGAG GGATCAGATG TCTGCTAGGG 
AAGCAGTTAC CCAATGGAGA CTGGCCTCAG GAGAACATCT CTGGGGTCTT CAACAAGTCC 
TGTGCCATCA GCTACACAAG TTACAGAAAC ATCTTCCCCA TCTGGGCCCT GGGCCGCTTC 
TCCAACCTGT ATCCTGACAA TACCCTCGCC GGCCACATTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_666118.1
CDS	57..2258
Translation	MTEGTCLRRRGGPYKTEPATDLTRWRLQNELGRQRWTYYQAEDDPGREQTGLEAHSLGLDTRSYFTDLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHISHISLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVSPDEMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQIWDTSFAIQALLEAGAHHRPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAEGLKAVLLLQNQCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALKHFHEHFPDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAACAEVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTSYRNIFPIWALGRFSNLYPDNTLAGHI

Target ORF information:

RefSeq Version	NM_146006.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus lanosterol synthase (Lss), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_146006.2

ORF Insert Sequence:

ATGACTGAGG GCACGTGTCT GCGGCGTCGT GGGGGACCCT ATAAAACTGA GCCCGCCACC 
GATCTCACCC GCTGGCGGCT CCAGAATGAG TTGGGTCGGC AGAGATGGAC TTATTATCAA 
GCGGAGGACG ACCCTGGTCG AGAGCAGACC GGGCTAGAGG CCCACTCTTT GGGACTGGAC 
ACAAGAAGTT ATTTCACGGA CTTACCAAAA GCGCAAACAG CCCATGAGGG GGCCCTGAAT 
GGAGTAACCT TTTATGCCAA GCTGCAGGCT GAGGATGGAC ACTGGGCTGG TGATTATGGT 
GGTCCGCTCT TCCTCTTGCC AGGTCTCCTG ATTACCTGTC ACATATCACA CATCTCTCTG 
CCAGCTGGAT ACAGAGAGGA GATGGTGCGG TACCTGCGGT CAGTGCAGCT CCCTGATGGC 
GGCTGGGGCT TGCACATCGA GGACAAGTCC ACAGTGTTTG GGACTGCCCT GAACTATGTG 
GCTCTCAGAA TCCTGGGTAT TGGGCCTGAT GATCCTGACC TTGTGCGCGC TCGGAACGTC 
CTTCACAAAA AAGGTGGTGC GGTGGCCATC CCTTCCTGGG GGAAGTTCTG GCTGGCTGTC 
CTGAATGTTT ATAGCTGGGA AGGACTCAAC ACCCTATTCC CTGAGATGTG GCTGTTTCCT 
GAATGGGTAC CAGCGCACCC CTCCACTCTC TGGTGTCACT GCCGGCAGGT CTATCTGCCC 
ATGAGTTACT GCTACGCCAC TCGGCTAAGT GCCTCAGAGG ACCCACTGGT TCAGAGCCTC 
CGCCAGGAAC TCTATGTGCA GGATTACGCC AGCATCGATT GGCCAGCGCA GAGGAACAAC 
GTGTCCCCCG ATGAGATGTA CACGCCACAC AGCTGGCTGC TGCATGTGGT GTATGGACTC 
CTCAACCTGT ATGAACGTTT CCATAGCACC AGCCTGCGGA AGTGGGCCGT CCAGATGCTG 
TATGAACACA TTGCAGCTGA TGACTGTTTC ACTAAGTGCA TCAGCATCGG CCCGATCTCA 
AAGACCATCA ACATGCTTGT TCGTTGGTCA GTGGATGGAC CATCCTCCCC GGCCTTCCAG 
GAGCACGTTT CTCGGATCAA AGATTACCTT TGGCTGGGCC TTGATGGCAT GAAAATGCAG 
GGCACCAATG GATCACAGAT CTGGGACACT TCATTTGCTA TCCAAGCACT GTTAGAGGCA 
GGTGCACACC ACAGACCTGA GTTTCTGCCC TGCCTGCAGA AGGCTCACGA GTTCCTGCGG 
CTTTCACAGG TTCCAGAAAA CTGTCCTGAC TATCAGAAGT ACTATCGCCA TATGCGCAAG 
GGTGGTTTCT CCTTCAGCAC ACTGGACTGT GGCTGGATCG TTGCTGACTG CACAGCCGAG 
GGTTTGAAGG CTGTGCTGCT CCTGCAGAAT CAGTGTCCGT CCATCACTGA GCATATCCCC 
CGAGAGCGGC TGTGCGATGC TGTGGATGTG TTACTGAGCT TGAGGAATGC TGATGGCGGG 
TTCGCTACCT ATGAGAAGAA GCGTGGGGGT TACTTGCTGG AGCTGCTGAA CCCCTCAGAG 
GTCTTTGGAG ACATCATGAT TGACTACACG TATGTAGAGT GTACCTCCGC TGTGATGCAG 
GCACTGAAGC ATTTCCATGA ACACTTCCCA GACTACAGGG CAGCAGAGGT CAGGGAGACC 
CTCAATCAAG GCCTGGACTT CTGCCGAAGG AAGCAGAGAG CCGATGGCTC CTGGGAGGGC 
TCCTGGGGTG TTTGTTTCAC CTACGGCACC TGGTTTGGCT TGGAAGCGTT CGCTTGCATG 
GGGCATACCT ACCAAGATGG GGCTGCTTGT GCAGAAGTAG CTCAGGCCTG CAACTTCCTC 
CTGTCCCAGC AGATGGCGGA TGGAGGCTGG GGAGAGGACT TTGAATCATG TGAACAGCGG 
CGGTATGTGC AGAGTGCTAG GTCCCAGGTC CATAGCACCT GCTGGGCCCT GATGGGTTTG 
ATGGCTGTCA GGCATCCCGA CATCACTGCT CAGGAGAGAG GGATCAGATG TCTGCTAGGG 
AAGCAGTTAC CCAATGGAGA CTGGCCTCAG GAGAACATCT CTGGGGTCTT CAACAAGTCC 
TGTGCCATCA GCTACACAAG TTACAGAAAC ATCTTCCCCA TCTGGGCCCT GGGCCGCTTC 
TCCAACCTGT ATCCTGACAA TACCCTCGCC GGCCACATTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.
Genes & development32(9-10)645-657(2018 05)
Kim M,Wende H,Walcher J,Kühnemund J,Cheret C,Kempa S,McShane E,Selbach M,Lewin GR,Birchmeier C

Normalization of Hepatic Homeostasis in the
The Journal of biological chemistry292(11)4395-4410(2017 03)
Munkacsi AB,Hammond N,Schneider RT,Senanayake DS,Higaki K,Lagutin K,Bloor SJ,Ory DS,Maue RA,Chen FW,Hernandez-Ono A,Dahlson N,Repa JJ,Ginsberg HN,Ioannou YA,Sturley SL

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
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Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.
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Lss cDNA ORF clone, Mus musculus(house mouse)

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