Alox15 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Alox15
Entrez Gene ID	81639
Full Name	arachidonate 15-lipoxygenase
Synonyms	12-LOX,15-LOX,Alox12,Alox12l
General protein information	Preferred Names arachidonate 15-lipoxygenase Names arachidonate 15-lipoxygenase 12/15-LOX 12/15-lipoxygenase arachidonate 12-lipoxygenase, leukocyte-type arachidonate omega-6 lipoxygenase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q24
Summary	demonstrates 12-lipoxygenase and some 15-lipoxygenase enzyme activity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006246823.3	XP_006246885.1	arachidonate 15-lipoxygenase isoform X1
NM_031010.2	NP_112272.2	arachidonate 15-lipoxygenase
XM_006246824.3	XP_006246886.1	arachidonate 15-lipoxygenase isoform X2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ALOX15	XP_003315361.1
Rattus norvegicus (Norway rat)	Alox15	NP_112272.2
Macaca mulatta (Rhesus monkey)	ALOX15	XP_001094627.1
Bos taurus (cattle)	ALOX15	NP_776926.1
Mus musculus (house mouse)	Alox15	NP_033790.3
Homo sapiens (human)	ALOX15	NP_001131.3
Canis lupus familiaris (dog)	ALOX15	XP_546576.2

Gene Ontology
Bibliography

Related articles in PubMed

Distribution of Alox15 in the Rat Brain and Its Role in Prefrontal Cortical Resolvin D1 Formation and Spatial Working Memory.
Shalini SM, Ho CF, Ng YK, Tong JX, Ong ES, Herr DR, Dawe GS, Ong WY
Molecular neurobiology55(2)1537-1550(2018 02)

Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model rats.
Wakabayashi M, Yoshioka T, Higashino K, Numata Y, Igarashi Y, Kihara A
Journal of dermatological science85(3)186-196(2017 Mar)

Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension.
Li Q, Mao M, Qiu Y, Liu G, Sheng T, Yu X, Wang S, Zhu D
PloS one11(2)e0149164(2016)

12/15-Lipoxygenase metabolites of arachidonic acid activate PPARγ: a possible neuroprotective effect in ischemic brain.
Sun L, Xu YW, Han J, Liang H, Wang N, Cheng Y
Journal of lipid research56(3)502-14(2015 Mar)

Microarray analysis of rat pancreas reveals altered expression of Alox15 and regenerating islet-derived genes in response to iron deficiency and overload.
Coffey R, Nam H, Knutson MD
PloS one9(1)e86019(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Alox15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Alox15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa07371	NM_031010.2 Latest version!	Rattus norvegicus arachidonate 15-lipoxygenase (Alox15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa33396	XM_006246823.3 Latest version!	Rattus norvegicus arachidonate 15-lipoxygenase (Alox15), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
ORa33397	XM_006246824.3 Latest version!	Rattus norvegicus arachidonate 15-lipoxygenase (Alox15), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Alox15 ( NM_031010.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112272.2 Rattus norvegicus arachidonate 15-lipoxygenase (Alox15), mRNA.

Price & Availability↑

CloneID	ORa07371
Clone ID Related Accession (Same CDS sequence)	NM_031010.2
Accession Version	NM_031010.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1992bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Rattus norvegicus(Norway rat)
Product	arachidonate 15-lipoxygenase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from S69383.1. On Jun 9, 2003 this sequence version replaced NM_031010.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L06040.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGGTGTCT ACCGCATCCG CGTCTCCACC GGAGACTCCA AGTACGCGGG CTCCAACAAC 
GAGGTCTACC TGTGGTTGGT TGGACAGCAT GGAGAGGCAT CTCTCGGGAA GCTGCTACGA 
CCCTGTCGGG ACTCGGAAGC AGAATTCAAA GTGGATGTGT CAGGATACCT TGGGCCACTG 
CTGTTCGTAA GAGTGCAGAA ATGGCATTAT CTCACGGATG ACGCCTGGTT CTGCAACTGG 
ATTTCTGTGA AGGGCCCCGG AGACCAAGGA TCAGAGTACA TGTTCCCCTG TTACCGATGG 
GTTCAGGGCA GAAGCATCCT GAGCCTCCCT GAGGGCACTG GCTGCACCGT GGTTGAAGAT 
TCTCAAGGAC TGTTCAGGAA ACATAGGGAA GAGGAGCTTG AAGAGAGGAG GAGTCTGTAC 
AGGTGGGGCA ACTGGAAGGA TGGCTCAATC CTGAATGTGG CGGCGGCCAG TATATCTGAC 
CTCCCTGTAG ACCAACGATT TCGAGAGGAC AAAAGAATTG AATTTGAAGC TTCACAGGTT 
ATAGGGGTAA TGGATACTGT TGTCAACTTT CCTATAAACA CTGTGACCTG CTGGAAAAGC 
CTAGATGACT TCAACTGCGT TTTCAAGAGT GGCCATACCA AAATGGCTGA GCGGGTTCGA 
AACTCCTGGA AGGAAGATGC GTTCTTTGGG TACCAATTCC TCAATGGTGC TAACCCCATG 
GTGCTGAAGC GCTCTACTTG TCTTCCTGCC CGCCTGGTAT TCCCTCCAGG AATGGAGAAG 
CTACAGGCCC AGCTGAACAA GGAGCTCCAG AAAGGCACTC TGTTTGAAGC GGATTTCTTC 
CTTCTGGATG GGATCAAGGC CAATGTCATC CTTTGTAGCC AGCAGTACCT GGCTGCCCCT 
CTCGTCATGC TGAAGCTGAT GCCTGATGGA CAACTCTTGC CCATAGCCAT CCAGCTTGAA 
CTTCCCAAAA CTGGGTCTAC TCCACCACCT ATTTTCACGC CCTCGGATCC CCCAATGGAC 
TGGCTCCTAG CCAAATGCTG GGTCCGGAGC TCCGACTTAC AGCTCCATGA GCTGCAGGCT 
CATCTTCTGA GGGGACACTT GATGGCTGAG GTCTTTGCTG TGGCCACCAT GAGGTGCCTG 
CCTTCCGTGC ACCCTGTTTT TAAGCTTCTA GTTCCTCATC TGCTTTACAC CATGGAAATT 
AATGTCCGGG CCAGGAGTGA CCTGATCTCA GAGAGAGGCT TTTTTGACAA GGCAATGAGC 
ACAGGTGGGG GAGGCCACCT GGATCTTCTC AAGCAAGCTG GAGCCTTTCT GACCTATTGC 
TCATTGTGTC CCCCCGATGA CTTGGCTGAG CGAGGACTCT TGGATATCGA GACTTGCTTC 
TATGCTAAAG ACGCCCTGCG ACTCTGGCAG ATCATGAATC GGTACGTGGT GGGAATGTTC 
AATCTCCACT ACAAGACCGA CAAAGCTGTG CAAGACGACT ATGAACTGCA GAGCTGGTGT 
CGAGAGATCA CTGACATTGG TCTTCAAGGG GCCCAGGACA GAGGCTTCCC TACCTCTCTT 
CAGTCCCGGG CTCAGGCTTG CTACTTCATC ACCATGTGCA TCTTCACGTG CACCGCACAG 
CACTCTTCCG TCCATCTTGG CCAGCTGGAT TGGTTCTACT GGGTTCCTAA TGCACCCTGC 
ACCATGCGGC TGCCACCACC CACCACCAAG GAAGCAACAA TGGAGAAGCT GATGGCTACA 
CTGCCCAACC CTAATCAGTC TACTCTCCAG ATAAATGTCG TTTGGCTCCT GGGCAGACGC 
CAGGCTGTTA TGGTGCCCCT GGGCCAGCAT TCAGAGGAAC ACTTTCCAAA CCCTGAGGCC 
AAGGCTGTGC TGAAGAAGTT CAGAGAGGAA CTGGCTGCCT TGGATAAGGA AATTGAGATT 
CGTAATAAGA GCTTGGACAT ACCTTATGAG TACCTGCGGC CCAGCATGGT GGAAAACAGC 
GTGGCCATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112272.2
CDS	7..1998
Translation	MGVYRIRVSTGDSKYAGSNNEVYLWLVGQHGEASLGKLLRPCRDSEAEFKVDVSGYLGPLLFVRVQKWHYLTDDAWFCNWISVKGPGDQGSEYMFPCYRWVQGRSILSLPEGTGCTVVEDSQGLFRKHREEELEERRSLYRWGNWKDGSILNVAAASISDLPVDQRFREDKRIEFEASQVIGVMDTVVNFPINTVTCWKSLDDFNCVFKSGHTKMAERVRNSWKEDAFFGYQFLNGANPMVLKRSTCLPARLVFPPGMEKLQAQLNKELQKGTLFEADFFLLDGIKANVILCSQQYLAAPLVMLKLMPDGQLLPIAIQLELPKTGSTPPPIFTPSDPPMDWLLAKCWVRSSDLQLHELQAHLLRGHLMAEVFAVATMRCLPSVHPVFKLLVPHLLYTMEINVRARSDLISERGFFDKAMSTGGGGHLDLLKQAGAFLTYCSLCPPDDLAERGLLDIETCFYAKDALRLWQIMNRYVVGMFNLHYKTDKAVQDDYELQSWCREITDIGLQGAQDRGFPTSLQSRAQACYFITMCIFTCTAQHSSVHLGQLDWFYWVPNAPCTMRLPPPTTKEATMEKLMATLPNPNQSTLQINVVWLLGRRQAVMVPLGQHSEEHFPNPEAKAVLKKFREELAALDKEIEIRNKSLDIPYEYLRPSMVENSVAI

Target ORF information:

RefSeq Version	NM_031010.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus arachidonate 15-lipoxygenase (Alox15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031010.2

ORF Insert Sequence:

ATGGGTGTCT ACCGCATCCG CGTCTCCACC GGAGACTCCA AGTACGCGGG CTCCAACAAC 
GAGGTCTACC TGTGGTTGGT TGGACAGCAT GGAGAGGCAT CTCTCGGGAA GCTGCTACGA 
CCCTGTCGGG ACTCGGAAGC AGAATTCAAA GTGGATGTGT CAGGATACCT TGGGCCACTG 
CTGTTCGTAA GAGTGCAGAA ATGGCATTAT CTCACGGATG ACGCCTGGTT CTGCAACTGG 
ATTTCTGTGA AGGGCCCCGG AGACCAAGGA TCAGAGTACA TGTTCCCCTG TTACCGATGG 
GTTCAGGGCA GAAGCATCCT GAGCCTCCCT GAGGGCACTG GCTGCACCGT GGTTGAAGAT 
TCTCAAGGAC TGTTCAGGAA ACATAGGGAA GAGGAGCTTG AAGAGAGGAG GAGTCTGTAC 
AGGTGGGGCA ACTGGAAGGA TGGCTCAATC CTGAATGTGG CGGCGGCCAG TATATCTGAC 
CTCCCTGTAG ACCAACGATT TCGAGAGGAC AAAAGAATTG AATTTGAAGC TTCACAGGTT 
ATAGGGGTAA TGGATACTGT TGTCAACTTT CCTATAAACA CTGTGACCTG CTGGAAAAGC 
CTAGATGACT TCAACTGCGT TTTCAAGAGT GGCCATACCA AAATGGCTGA GCGGGTTCGA 
AACTCCTGGA AGGAAGATGC GTTCTTTGGG TACCAATTCC TCAATGGTGC TAACCCCATG 
GTGCTGAAGC GCTCTACTTG TCTTCCTGCC CGCCTGGTAT TCCCTCCAGG AATGGAGAAG 
CTACAGGCCC AGCTGAACAA GGAGCTCCAG AAAGGCACTC TGTTTGAAGC GGATTTCTTC 
CTTCTGGATG GGATCAAGGC CAATGTCATC CTTTGTAGCC AGCAGTACCT GGCTGCCCCT 
CTCGTCATGC TGAAGCTGAT GCCTGATGGA CAACTCTTGC CCATAGCCAT CCAGCTTGAA 
CTTCCCAAAA CTGGGTCTAC TCCACCACCT ATTTTCACGC CCTCGGATCC CCCAATGGAC 
TGGCTCCTAG CCAAATGCTG GGTCCGGAGC TCCGACTTAC AGCTCCATGA GCTGCAGGCT 
CATCTTCTGA GGGGACACTT GATGGCTGAG GTCTTTGCTG TGGCCACCAT GAGGTGCCTG 
CCTTCCGTGC ACCCTGTTTT TAAGCTTCTA GTTCCTCATC TGCTTTACAC CATGGAAATT 
AATGTCCGGG CCAGGAGTGA CCTGATCTCA GAGAGAGGCT TTTTTGACAA GGCAATGAGC 
ACAGGTGGGG GAGGCCACCT GGATCTTCTC AAGCAAGCTG GAGCCTTTCT GACCTATTGC 
TCATTGTGTC CCCCCGATGA CTTGGCTGAG CGAGGACTCT TGGATATCGA GACTTGCTTC 
TATGCTAAAG ACGCCCTGCG ACTCTGGCAG ATCATGAATC GGTACGTGGT GGGAATGTTC 
AATCTCCACT ACAAGACCGA CAAAGCTGTG CAAGACGACT ATGAACTGCA GAGCTGGTGT 
CGAGAGATCA CTGACATTGG TCTTCAAGGG GCCCAGGACA GAGGCTTCCC TACCTCTCTT 
CAGTCCCGGG CTCAGGCTTG CTACTTCATC ACCATGTGCA TCTTCACGTG CACCGCACAG 
CACTCTTCCG TCCATCTTGG CCAGCTGGAT TGGTTCTACT GGGTTCCTAA TGCACCCTGC 
ACCATGCGGC TGCCACCACC CACCACCAAG GAAGCAACAA TGGAGAAGCT GATGGCTACA 
CTGCCCAACC CTAATCAGTC TACTCTCCAG ATAAATGTCG TTTGGCTCCT GGGCAGACGC 
CAGGCTGTTA TGGTGCCCCT GGGCCAGCAT TCAGAGGAAC ACTTTCCAAA CCCTGAGGCC 
AAGGCTGTGC TGAAGAAGTT CAGAGAGGAA CTGGCTGCCT TGGATAAGGA AATTGAGATT 
CGTAATAAGA GCTTGGACAT ACCTTATGAG TACCTGCGGC CCAGCATGGT GGAAAACAGC 
GTGGCCATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Alox15 ( XM_006246823.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006246885.1 Rattus norvegicus arachidonate 15-lipoxygenase (Alox15), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa33396
Clone ID Related Accession (Same CDS sequence)	XM_006246823.3
Accession Version	XM_006246823.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2187bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	arachidonate 15-lipoxygenase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006246823.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGAGGC ATCTCTCGGG AAGCTGCTAC GACCCTGTCG GGACTCGATA TTGGATCTCT 
GATTTTAGGA CCGAACGGGT GGTGCAATGG GAAGGAAGAA AGGTGGGAGG CAGGAAGCAA 
TACTCTGCAA GGCTCGCTGT TAGATGTGGC AGGTTTCTCC TTAAAGACCA TCCTCTGGAA 
ACCCTGGCTC AGACCAAATG GAATTCCCAT GGATCCTCTG CCTTGGCGGG GTGTCCCATC 
TCACCTGTAT CCTCACTGGG CTTCAGGCAG GGTTTCCAGC GTTGCTCCTC CTCCAGTCTC 
CCCACTCCAC CAAGGGCAAA GGAAAGGAAG GAAGCAGAAT TCAAAGTGGA TGTGTCAGAA 
TACCTTGGGC CACTGCTGTT CGTAAGAGTG CAGAAATGGC ATTATCTCAC GGATGACGCC 
TGGTTCTGCA ACTGGATTTC TGTGAAGGGC CCCGGAGACC AAGGATCAGA GTACATGTTC 
CCCTGTTACC GATGGGTTCA GGGCAGAAGC ATCCTGAGCC TCCCTGAGGG CACTGGCTGC 
ACCGTGGTTG AAGATTCTCA AGGACTGTTC AGGAAACATA GGGAAGAGGA GCTTGAAGAG 
AGGAGGAGTC TGTACAGGTG GGGCAACTGG AAGGATGGCT CAATCCTGAA TGTGGCGGCG 
GCCAGTATAT CTGACCTCCC TGTAGACCAA CGATTTCGAG AGGACAAAAG AATTGAATTT 
GAAGCTTCAC AGGTTATAGG GGTAATGGAT ACTGTTGTCA ACTTTCCTAT AAACACTGTG 
ACCTGCTGGA AAAGCCTAGA TGACTTCAAC TGCGTTTTCA AGAGTGGCCA TACCAAAATG 
GCTGAGCGGG TTCGAAACTC CTGGAAGGAA GATGCGTTCT TTGGGTACCA ATTTCTCAAT 
GGTGCTAACC CCATGGTGCT GAAGCGCTCT ACTTGTCTTC CTGCCCGCCT GGTATTCCCT 
CCAGGAATGG AGAAGCTACA GGCCCAGCTG AACAAGGAGC TCCAGAAAGG CACTCTGTTT 
GAAGCGGATT TCTTCCTTCT GGATGGGATC AAGGCCAATG TCATCCTTTG TAGCCAGCAG 
TACCTGGCTG CCCCTCTCGT CATGCTGAAG CTGATGCCTG ATGGACAACT CTTGCCCATA 
GCCATCCAGC TTGAACTGCC CAAAACTGGG TCTACTCCAC CACCTATTTT CACGCCCTCG 
GATCCCCCAA TGGACTGGCT CCTAGCCAAA TGCTGGGTCC GGAGCTCCGA CTTACAGCTC 
CATGAGCTGC AGGCTCATCT TCTGAGGGGA CACTTGATGG CTGAGGTCTT TGCTGTGGCC 
ACCATGAGGT GCCTGCCTTC CGTGCACCCT GTTTTTAAGC TTCTAGTTCC TCATCTGCTT 
TACACCATGG AAATTAATGT CCGGGCCAGG AGTGACCTGA TCTCAGAGAG AGGCTTTTTT 
GACAAGGCAA TGAGCACAGG TGGGGGAGGC CACCTGGATC TTCTCAAGCA AGCTGGAGCC 
TTTCTGACCT ATTGCTCATT GTGTCCCCCC GATGACTTGG CTGAGCGAGG ACTCTTGGAT 
ATCGAGACTT GCTTCTATGC TAAAGACGCC CTGCGACTCT GGCAGATCAT GAATCGGTAC 
GTGGTGGGAA TGTTCAATCT CCACTACAAG ACCGACAAAG CTGTGCAAGA CGACTATGAA 
CTGCAGAGCT GGTGTCGAGA GATCACTGAC ATTGGTCTTC AAGGGGCCCA GGACAGAGGC 
TTCCCTACCT CTCTTCAGTC CCGGGCTCAG GCTTGCTACT TCATCACCAT GTGCATCTTC 
ACGTGCACCG CACAGCACTC TTCCGTCCAT CTTGGCCAGC TGGATTGGTT CTACTGGGTT 
CCTAATGCAC CCTGCACCAT GCGGCTGCCA CCACCCACCA CCAAGGAAGC AACAATGGAG 
AAGCTGATGG CTACACTGCC CAACCCTAAT CAGTCTACTC TCCAGATAAA TGTCGTTTGG 
CTCCTGGGCA GACGCCAGGC TGTTATGGTG CCCCTGGGCC AGCATTCAGA GGAACACTTT 
CCAAACCCTG AGGCCAAGGC TGTGCTGAAG AAGTTCAGAG AGGAACTGGC TGCCTTGGAT 
AAGGAAATTG AGATTCGTAA TAAGAGCTTG GACATACCTT ATGAGTACCT GCGGCCCAGC 
ATGGTGGAAA ACAGCGTGGC CATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006246885.1
CDS	100..2286
Translation	MERHLSGSCYDPVGTRYWISDFRTERVVQWEGRKVGGRKQYSARLAVRCGRFLLKDHPLETLAQTKWNSHGSSALAGCPISPVSSLGFRQGFQRCSSSSLPTPPRAKERKEAEFKVDVSEYLGPLLFVRVQKWHYLTDDAWFCNWISVKGPGDQGSEYMFPCYRWVQGRSILSLPEGTGCTVVEDSQGLFRKHREEELEERRSLYRWGNWKDGSILNVAAASISDLPVDQRFREDKRIEFEASQVIGVMDTVVNFPINTVTCWKSLDDFNCVFKSGHTKMAERVRNSWKEDAFFGYQFLNGANPMVLKRSTCLPARLVFPPGMEKLQAQLNKELQKGTLFEADFFLLDGIKANVILCSQQYLAAPLVMLKLMPDGQLLPIAIQLELPKTGSTPPPIFTPSDPPMDWLLAKCWVRSSDLQLHELQAHLLRGHLMAEVFAVATMRCLPSVHPVFKLLVPHLLYTMEINVRARSDLISERGFFDKAMSTGGGGHLDLLKQAGAFLTYCSLCPPDDLAERGLLDIETCFYAKDALRLWQIMNRYVVGMFNLHYKTDKAVQDDYELQSWCREITDIGLQGAQDRGFPTSLQSRAQACYFITMCIFTCTAQHSSVHLGQLDWFYWVPNAPCTMRLPPPTTKEATMEKLMATLPNPNQSTLQINVVWLLGRRQAVMVPLGQHSEEHFPNPEAKAVLKKFREELAALDKEIEIRNKSLDIPYEYLRPSMVENSVAI

Target ORF information:

RefSeq Version	XM_006246823.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus arachidonate 15-lipoxygenase (Alox15), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006246823.3

ORF Insert Sequence:

ATGGAGAGGC ATCTCTCGGG AAGCTGCTAC GACCCTGTCG GGACTCGATA TTGGATCTCT 
GATTTTAGGA CCGAACGGGT GGTGCAATGG GAAGGAAGAA AGGTGGGAGG CAGGAAGCAA 
TACTCTGCAA GGCTCGCTGT TAGATGTGGC AGGTTTCTCC TTAAAGACCA TCCTCTGGAA 
ACCCTGGCTC AGACCAAATG GAATTCCCAT GGATCCTCTG CCTTGGCGGG GTGTCCCATC 
TCACCTGTAT CCTCACTGGG CTTCAGGCAG GGTTTCCAGC GTTGCTCCTC CTCCAGTCTC 
CCCACTCCAC CAAGGGCAAA GGAAAGGAAG GAAGCAGAAT TCAAAGTGGA TGTGTCAGAA 
TACCTTGGGC CACTGCTGTT CGTAAGAGTG CAGAAATGGC ATTATCTCAC GGATGACGCC 
TGGTTCTGCA ACTGGATTTC TGTGAAGGGC CCCGGAGACC AAGGATCAGA GTACATGTTC 
CCCTGTTACC GATGGGTTCA GGGCAGAAGC ATCCTGAGCC TCCCTGAGGG CACTGGCTGC 
ACCGTGGTTG AAGATTCTCA AGGACTGTTC AGGAAACATA GGGAAGAGGA GCTTGAAGAG 
AGGAGGAGTC TGTACAGGTG GGGCAACTGG AAGGATGGCT CAATCCTGAA TGTGGCGGCG 
GCCAGTATAT CTGACCTCCC TGTAGACCAA CGATTTCGAG AGGACAAAAG AATTGAATTT 
GAAGCTTCAC AGGTTATAGG GGTAATGGAT ACTGTTGTCA ACTTTCCTAT AAACACTGTG 
ACCTGCTGGA AAAGCCTAGA TGACTTCAAC TGCGTTTTCA AGAGTGGCCA TACCAAAATG 
GCTGAGCGGG TTCGAAACTC CTGGAAGGAA GATGCGTTCT TTGGGTACCA ATTTCTCAAT 
GGTGCTAACC CCATGGTGCT GAAGCGCTCT ACTTGTCTTC CTGCCCGCCT GGTATTCCCT 
CCAGGAATGG AGAAGCTACA GGCCCAGCTG AACAAGGAGC TCCAGAAAGG CACTCTGTTT 
GAAGCGGATT TCTTCCTTCT GGATGGGATC AAGGCCAATG TCATCCTTTG TAGCCAGCAG 
TACCTGGCTG CCCCTCTCGT CATGCTGAAG CTGATGCCTG ATGGACAACT CTTGCCCATA 
GCCATCCAGC TTGAACTGCC CAAAACTGGG TCTACTCCAC CACCTATTTT CACGCCCTCG 
GATCCCCCAA TGGACTGGCT CCTAGCCAAA TGCTGGGTCC GGAGCTCCGA CTTACAGCTC 
CATGAGCTGC AGGCTCATCT TCTGAGGGGA CACTTGATGG CTGAGGTCTT TGCTGTGGCC 
ACCATGAGGT GCCTGCCTTC CGTGCACCCT GTTTTTAAGC TTCTAGTTCC TCATCTGCTT 
TACACCATGG AAATTAATGT CCGGGCCAGG AGTGACCTGA TCTCAGAGAG AGGCTTTTTT 
GACAAGGCAA TGAGCACAGG TGGGGGAGGC CACCTGGATC TTCTCAAGCA AGCTGGAGCC 
TTTCTGACCT ATTGCTCATT GTGTCCCCCC GATGACTTGG CTGAGCGAGG ACTCTTGGAT 
ATCGAGACTT GCTTCTATGC TAAAGACGCC CTGCGACTCT GGCAGATCAT GAATCGGTAC 
GTGGTGGGAA TGTTCAATCT CCACTACAAG ACCGACAAAG CTGTGCAAGA CGACTATGAA 
CTGCAGAGCT GGTGTCGAGA GATCACTGAC ATTGGTCTTC AAGGGGCCCA GGACAGAGGC 
TTCCCTACCT CTCTTCAGTC CCGGGCTCAG GCTTGCTACT TCATCACCAT GTGCATCTTC 
ACGTGCACCG CACAGCACTC TTCCGTCCAT CTTGGCCAGC TGGATTGGTT CTACTGGGTT 
CCTAATGCAC CCTGCACCAT GCGGCTGCCA CCACCCACCA CCAAGGAAGC AACAATGGAG 
AAGCTGATGG CTACACTGCC CAACCCTAAT CAGTCTACTC TCCAGATAAA TGTCGTTTGG 
CTCCTGGGCA GACGCCAGGC TGTTATGGTG CCCCTGGGCC AGCATTCAGA GGAACACTTT 
CCAAACCCTG AGGCCAAGGC TGTGCTGAAG AAGTTCAGAG AGGAACTGGC TGCCTTGGAT 
AAGGAAATTG AGATTCGTAA TAAGAGCTTG GACATACCTT ATGAGTACCT GCGGCCCAGC 
ATGGTGGAAA ACAGCGTGGC CATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Alox15 ( XM_006246824.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006246886.1 Rattus norvegicus arachidonate 15-lipoxygenase (Alox15), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa33397
Clone ID Related Accession (Same CDS sequence)	XM_006246824.3
Accession Version	XM_006246824.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2082bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	arachidonate 15-lipoxygenase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006246824.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGAGGC ATCTCTCGGG AAGCTGCTAC GACCCTGTCG GGACTCGGTT TCTCCTTAAA 
GACCATCCTC TGGAAACCCT GGCTCAGACC AAATGGAATT CCCATGGATC CTCTGCCTTG 
GCGGGGTGTC CCATCTCACC TGTATCCTCA CTGGGCTTCA GGCAGGGTTT CCAGCGTTGC 
TCCTCCTCCA GTCTCCCCAC TCCACCAAGG GCAAAGGAAA GGAAGGAAGC AGAATTCAAA 
GTGGATGTGT CAGAATACCT TGGGCCACTG CTGTTCGTAA GAGTGCAGAA ATGGCATTAT 
CTCACGGATG ACGCCTGGTT CTGCAACTGG ATTTCTGTGA AGGGCCCCGG AGACCAAGGA 
TCAGAGTACA TGTTCCCCTG TTACCGATGG GTTCAGGGCA GAAGCATCCT GAGCCTCCCT 
GAGGGCACTG GCTGCACCGT GGTTGAAGAT TCTCAAGGAC TGTTCAGGAA ACATAGGGAA 
GAGGAGCTTG AAGAGAGGAG GAGTCTGTAC AGGTGGGGCA ACTGGAAGGA TGGCTCAATC 
CTGAATGTGG CGGCGGCCAG TATATCTGAC CTCCCTGTAG ACCAACGATT TCGAGAGGAC 
AAAAGAATTG AATTTGAAGC TTCACAGGTT ATAGGGGTAA TGGATACTGT TGTCAACTTT 
CCTATAAACA CTGTGACCTG CTGGAAAAGC CTAGATGACT TCAACTGCGT TTTCAAGAGT 
GGCCATACCA AAATGGCTGA GCGGGTTCGA AACTCCTGGA AGGAAGATGC GTTCTTTGGG 
TACCAATTTC TCAATGGTGC TAACCCCATG GTGCTGAAGC GCTCTACTTG TCTTCCTGCC 
CGCCTGGTAT TCCCTCCAGG AATGGAGAAG CTACAGGCCC AGCTGAACAA GGAGCTCCAG 
AAAGGCACTC TGTTTGAAGC GGATTTCTTC CTTCTGGATG GGATCAAGGC CAATGTCATC 
CTTTGTAGCC AGCAGTACCT GGCTGCCCCT CTCGTCATGC TGAAGCTGAT GCCTGATGGA 
CAACTCTTGC CCATAGCCAT CCAGCTTGAA CTGCCCAAAA CTGGGTCTAC TCCACCACCT 
ATTTTCACGC CCTCGGATCC CCCAATGGAC TGGCTCCTAG CCAAATGCTG GGTCCGGAGC 
TCCGACTTAC AGCTCCATGA GCTGCAGGCT CATCTTCTGA GGGGACACTT GATGGCTGAG 
GTCTTTGCTG TGGCCACCAT GAGGTGCCTG CCTTCCGTGC ACCCTGTTTT TAAGCTTCTA 
GTTCCTCATC TGCTTTACAC CATGGAAATT AATGTCCGGG CCAGGAGTGA CCTGATCTCA 
GAGAGAGGCT TTTTTGACAA GGCAATGAGC ACAGGTGGGG GAGGCCACCT GGATCTTCTC 
AAGCAAGCTG GAGCCTTTCT GACCTATTGC TCATTGTGTC CCCCCGATGA CTTGGCTGAG 
CGAGGACTCT TGGATATCGA GACTTGCTTC TATGCTAAAG ACGCCCTGCG ACTCTGGCAG 
ATCATGAATC GGTACGTGGT GGGAATGTTC AATCTCCACT ACAAGACCGA CAAAGCTGTG 
CAAGACGACT ATGAACTGCA GAGCTGGTGT CGAGAGATCA CTGACATTGG TCTTCAAGGG 
GCCCAGGACA GAGGCTTCCC TACCTCTCTT CAGTCCCGGG CTCAGGCTTG CTACTTCATC 
ACCATGTGCA TCTTCACGTG CACCGCACAG CACTCTTCCG TCCATCTTGG CCAGCTGGAT 
TGGTTCTACT GGGTTCCTAA TGCACCCTGC ACCATGCGGC TGCCACCACC CACCACCAAG 
GAAGCAACAA TGGAGAAGCT GATGGCTACA CTGCCCAACC CTAATCAGTC TACTCTCCAG 
ATAAATGTCG TTTGGCTCCT GGGCAGACGC CAGGCTGTTA TGGTGCCCCT GGGCCAGCAT 
TCAGAGGAAC ACTTTCCAAA CCCTGAGGCC AAGGCTGTGC TGAAGAAGTT CAGAGAGGAA 
CTGGCTGCCT TGGATAAGGA AATTGAGATT CGTAATAAGA GCTTGGACAT ACCTTATGAG 
TACCTGCGGC CCAGCATGGT GGAAAACAGC GTGGCCATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006246886.1
CDS	100..2181
Translation	MERHLSGSCYDPVGTRFLLKDHPLETLAQTKWNSHGSSALAGCPISPVSSLGFRQGFQRCSSSSLPTPPRAKERKEAEFKVDVSEYLGPLLFVRVQKWHYLTDDAWFCNWISVKGPGDQGSEYMFPCYRWVQGRSILSLPEGTGCTVVEDSQGLFRKHREEELEERRSLYRWGNWKDGSILNVAAASISDLPVDQRFREDKRIEFEASQVIGVMDTVVNFPINTVTCWKSLDDFNCVFKSGHTKMAERVRNSWKEDAFFGYQFLNGANPMVLKRSTCLPARLVFPPGMEKLQAQLNKELQKGTLFEADFFLLDGIKANVILCSQQYLAAPLVMLKLMPDGQLLPIAIQLELPKTGSTPPPIFTPSDPPMDWLLAKCWVRSSDLQLHELQAHLLRGHLMAEVFAVATMRCLPSVHPVFKLLVPHLLYTMEINVRARSDLISERGFFDKAMSTGGGGHLDLLKQAGAFLTYCSLCPPDDLAERGLLDIETCFYAKDALRLWQIMNRYVVGMFNLHYKTDKAVQDDYELQSWCREITDIGLQGAQDRGFPTSLQSRAQACYFITMCIFTCTAQHSSVHLGQLDWFYWVPNAPCTMRLPPPTTKEATMEKLMATLPNPNQSTLQINVVWLLGRRQAVMVPLGQHSEEHFPNPEAKAVLKKFREELAALDKEIEIRNKSLDIPYEYLRPSMVENSVAI

Target ORF information:

RefSeq Version	XM_006246824.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus arachidonate 15-lipoxygenase (Alox15), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006246824.3

ORF Insert Sequence:

ATGGAGAGGC ATCTCTCGGG AAGCTGCTAC GACCCTGTCG GGACTCGGTT TCTCCTTAAA 
GACCATCCTC TGGAAACCCT GGCTCAGACC AAATGGAATT CCCATGGATC CTCTGCCTTG 
GCGGGGTGTC CCATCTCACC TGTATCCTCA CTGGGCTTCA GGCAGGGTTT CCAGCGTTGC 
TCCTCCTCCA GTCTCCCCAC TCCACCAAGG GCAAAGGAAA GGAAGGAAGC AGAATTCAAA 
GTGGATGTGT CAGAATACCT TGGGCCACTG CTGTTCGTAA GAGTGCAGAA ATGGCATTAT 
CTCACGGATG ACGCCTGGTT CTGCAACTGG ATTTCTGTGA AGGGCCCCGG AGACCAAGGA 
TCAGAGTACA TGTTCCCCTG TTACCGATGG GTTCAGGGCA GAAGCATCCT GAGCCTCCCT 
GAGGGCACTG GCTGCACCGT GGTTGAAGAT TCTCAAGGAC TGTTCAGGAA ACATAGGGAA 
GAGGAGCTTG AAGAGAGGAG GAGTCTGTAC AGGTGGGGCA ACTGGAAGGA TGGCTCAATC 
CTGAATGTGG CGGCGGCCAG TATATCTGAC CTCCCTGTAG ACCAACGATT TCGAGAGGAC 
AAAAGAATTG AATTTGAAGC TTCACAGGTT ATAGGGGTAA TGGATACTGT TGTCAACTTT 
CCTATAAACA CTGTGACCTG CTGGAAAAGC CTAGATGACT TCAACTGCGT TTTCAAGAGT 
GGCCATACCA AAATGGCTGA GCGGGTTCGA AACTCCTGGA AGGAAGATGC GTTCTTTGGG 
TACCAATTTC TCAATGGTGC TAACCCCATG GTGCTGAAGC GCTCTACTTG TCTTCCTGCC 
CGCCTGGTAT TCCCTCCAGG AATGGAGAAG CTACAGGCCC AGCTGAACAA GGAGCTCCAG 
AAAGGCACTC TGTTTGAAGC GGATTTCTTC CTTCTGGATG GGATCAAGGC CAATGTCATC 
CTTTGTAGCC AGCAGTACCT GGCTGCCCCT CTCGTCATGC TGAAGCTGAT GCCTGATGGA 
CAACTCTTGC CCATAGCCAT CCAGCTTGAA CTGCCCAAAA CTGGGTCTAC TCCACCACCT 
ATTTTCACGC CCTCGGATCC CCCAATGGAC TGGCTCCTAG CCAAATGCTG GGTCCGGAGC 
TCCGACTTAC AGCTCCATGA GCTGCAGGCT CATCTTCTGA GGGGACACTT GATGGCTGAG 
GTCTTTGCTG TGGCCACCAT GAGGTGCCTG CCTTCCGTGC ACCCTGTTTT TAAGCTTCTA 
GTTCCTCATC TGCTTTACAC CATGGAAATT AATGTCCGGG CCAGGAGTGA CCTGATCTCA 
GAGAGAGGCT TTTTTGACAA GGCAATGAGC ACAGGTGGGG GAGGCCACCT GGATCTTCTC 
AAGCAAGCTG GAGCCTTTCT GACCTATTGC TCATTGTGTC CCCCCGATGA CTTGGCTGAG 
CGAGGACTCT TGGATATCGA GACTTGCTTC TATGCTAAAG ACGCCCTGCG ACTCTGGCAG 
ATCATGAATC GGTACGTGGT GGGAATGTTC AATCTCCACT ACAAGACCGA CAAAGCTGTG 
CAAGACGACT ATGAACTGCA GAGCTGGTGT CGAGAGATCA CTGACATTGG TCTTCAAGGG 
GCCCAGGACA GAGGCTTCCC TACCTCTCTT CAGTCCCGGG CTCAGGCTTG CTACTTCATC 
ACCATGTGCA TCTTCACGTG CACCGCACAG CACTCTTCCG TCCATCTTGG CCAGCTGGAT 
TGGTTCTACT GGGTTCCTAA TGCACCCTGC ACCATGCGGC TGCCACCACC CACCACCAAG 
GAAGCAACAA TGGAGAAGCT GATGGCTACA CTGCCCAACC CTAATCAGTC TACTCTCCAG 
ATAAATGTCG TTTGGCTCCT GGGCAGACGC CAGGCTGTTA TGGTGCCCCT GGGCCAGCAT 
TCAGAGGAAC ACTTTCCAAA CCCTGAGGCC AAGGCTGTGC TGAAGAAGTT CAGAGAGGAA 
CTGGCTGCCT TGGATAAGGA AATTGAGATT CGTAATAAGA GCTTGGACAT ACCTTATGAG 
TACCTGCGGC CCAGCATGGT GGAAAACAGC GTGGCCATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Distribution of Alox15 in the Rat Brain and Its Role in Prefrontal Cortical Resolvin D1 Formation and Spatial Working Memory.
Molecular neurobiology55(2)1537-1550(2018 02)
Shalini SM,Ho CF,Ng YK,Tong JX,Ong ES,Herr DR,Dawe GS,Ong WY

Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model rats.
Journal of dermatological science85(3)186-196(2017 Mar)
Wakabayashi M,Yoshioka T,Higashino K,Numata Y,Igarashi Y,Kihara A

Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension.
PloS one11(2)e0149164(2016)
Li Q,Mao M,Qiu Y,Liu G,Sheng T,Yu X,Wang S,Zhu D

12/15-Lipoxygenase metabolites of arachidonic acid activate PPARγ: a possible neuroprotective effect in ischemic brain.
Journal of lipid research56(3)502-14(2015 Mar)
Sun L,Xu YW,Han J,Liang H,Wang N,Cheng Y

Microarray analysis of rat pancreas reveals altered expression of Alox15 and regenerating islet-derived genes in response to iron deficiency and overload.
PloS one9(1)e86019(2014)
Coffey R,Nam H,Knutson MD

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Alox15 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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