Alox15 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Alox15
Entrez Gene ID	11687
Full Name	arachidonate 15-lipoxygenase
Synonyms	12-LO,12/15-LO,15-LOX,Alox12l,L-12LO
General protein information	Preferred Names arachidonate 15-lipoxygenase Names arachidonate 15-lipoxygenase 12-LOX 12/15-lipoxygenase arachidonate 12-lipoxygenase, leukocyte-type arachidonate omega-6 lipoxygenase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 B3\|11 42.99 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006532036.4	XP_006532099.1	arachidonate 15-lipoxygenase isoform X1
XM_006532036.3	XP_006532099.1	arachidonate 15-lipoxygenase isoform X1
NM_009660.3	NP_033790.3	arachidonate 15-lipoxygenase

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ALOX15	XP_003315361.1
Rattus norvegicus (Norway rat)	Alox15	NP_112272.2
Macaca mulatta (Rhesus monkey)	ALOX15	XP_001094627.1
Bos taurus (cattle)	ALOX15	NP_776926.1
Mus musculus (house mouse)	Alox15	NP_033790.3
Homo sapiens (human)	ALOX15	NP_001131.3
Canis lupus familiaris (dog)	ALOX15	XP_546576.2

Gene Ontology
Bibliography

Related articles in PubMed

Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet β cells.
Conteh AM, Reissaus CA, Hernandez-Perez M, Nakshatri S, Anderson RM, Mirmira RG, Tersey SA, Linnemann AK
The Journal of biological chemistry294(16)6612-6620(2019 04)

Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage.
Gaberel T, Gakuba C, Zheng Y, Lépine M, Lo EH, van Leyen K
Stroke50(2)520-523(2019 02)

Immunoregulatory role of 15-lipoxygenase in the pathogenesis of bacterial keratitis.
Carion TW, Greenwood M, Ebrahim AS, Jerome A, Suvas S, Gronert K, Berger EA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology32(9)5026-5038(2018 09)

MMP-2 and MMP-9 contribute to the angiogenic effect produced by hypoxia/15-HETE in pulmonary endothelial cells.
Liu Y, Zhang H, Yan L, Du W, Zhang M, Chen H, Zhang L, Li G, Li J, Dong Y, Zhu D
Journal of molecular and cellular cardiology12136-50(2018 08)

Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase.
Hinman A, Holst CR, Latham JC, Bruegger JJ, Ulas G, McCusker KP, Amagata A, Davis D, Hoff KG, Kahn-Kirby AH, Kim V, Kosaka Y, Lee E, Malone SA, Mei JJ, Richards SJ, Rivera V, Miller G, Trimmer JK, Shrader WD
PloS one13(8)e0201369(2018)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Alox15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Alox15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19098	NM_009660.3 Latest version!	Mus musculus arachidonate 15-lipoxygenase (Alox15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OMu45440	XM_006532036.4 Latest version!	Mus musculus arachidonate 15-lipoxygenase (Alox15), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
View Old Accession Versions >>
OMu45440	XM_006532036.3	Mus musculus arachidonate 15-lipoxygenase (Alox15), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Alox15 ( NM_009660.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033790.3 Mus musculus arachidonate 15-lipoxygenase (Alox15), mRNA.

Price & Availability↑

CloneID	OMu19098
Clone ID Related Accession (Same CDS sequence)	NM_009660.3
Accession Version	NM_009660.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1992bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1574092800000
Organism	Mus musculus(house mouse)
Product	arachidonate 15-lipoxygenase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK142371.1, U04331.1 and AL596096.7. On Mar 31, 2007 this sequence version replaced NM_009660.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK142371.1, L34570.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTGTCT ACCGCATCCG CGTCTCCACC GGGGACTCCG TGTACGCGGG CTCCAACAAC 
GAGGTCTACC TGTGGTTGAT CGGACAGCAT GGGGAGGCAT CTCTCGGGAA GCTGTTCCGA 
CCCTGTCGGA ACTCGGAGGC AGAATTCAAG GTGGATGTGT CAGAATACCT TGGGCCACTG 
CTGTTTGTGA GAGTGCAGAA ATGGCATTAT CTCAAAGAGG ACGCCTGGTT CTGCAACTGG 
ATTTCTGTGA AGGGCCCCGG AGACCAGGGA TCGGAGTACA CGTTCCCCTG TTACCGATGG 
GTTCAGGGCA CCAGCATCCT GAACCTCCCT GAGGGCACTG GCTGCACCGT GGTTGAAGAC 
TCTCAAGGCC TGTTCAGGAA CCACAGGGAG GAGGAACTGG AAGAAAGGAG GAGTCTGTAC 
AGGTGGGGCA ACTGGAAGGA TGGCACAATC CTGAACGTGG CGGCGACCAG TATCTCTGAC 
CTCCCTGTAG ACCAGCGATT TCGAGAGGAC AAAAGACTTG AATTTGAAGC TTCACAGGTT 
CTGGGGACAA TGGACACCGT TATTAACTTC CCTAAAAACA CTGTGACCTG CTGGAAAAGC 
CTAGATGACT TCAACTATGT TTTCAAGAGT GGCCACACCA AGATGGCTGA GCGGGTTCGA 
AACTCCTGGA AAGAGGATGC TTTCTTTGGG TACCAGTTTC TCAATGGTGC TAACCCCATG 
GTGCTGAAGC GGTCTACTTG TCTCCCTGCC CGCCTGGTAT TCCCTCCGGG GATGGAGAAG 
CTACAGGCCC AGCTGGATGA GGAGCTCAAG AAAGGCACTC TGTTTGAAGC GGATTTCTTC 
CTTCTGGATG GGATCAAGGC CAATGTCATC CTTTGTAGTC AGCAGTACCT GGCTGCCCCC 
CTCGTCATGC TGAAGCTGCA GCCCGATGGG CAACTCTTGC CTATAGCCAT CCAGCTCGAA 
CTGCCCAAAA CTGGGTCTAC CCCACCGCCG ATTTTCACGC CCTTGGATCC CCCAATGGAC 
TGGCTCCTGG CCAAATGCTG GGTCCGAAGC TCAGACTTAC AGCTTCATGA GCTACAGGCT 
CATCTTCTGA GGGGACACTT GGTGGCTGAG GTCTTTGCTG TGGCCACCAT GAGGTGCCTG 
CCTTCCGTGC ACCCTGTTTT TAAGCTTCTA GTTCCTCACC TACTCTACAC CATGGAAATC 
AATGTCCGGG CCAGGAGCGA CCTGATCTCA GAGAGAGGCT TTTTTGACAA GGTGATGAGC 
ACAGGTGGAG GAGGCCACCT GGATCTTCTC AAGCAAGCTG GAGCCTTCCT GACCTACAGC 
TCATTGTGTC CCCCTGATGA CTTGGCTGAG CGAGGACTCC TGGATATTGA CACTTGCTTC 
TATGCTAAAG ATGCCCTGCA GCTCTGGCAA GTCATGAATC GGTACGTGGT GGGAATGTTC 
GATCTCTACT ACAAGACCGA CCAAGCTGTT CAGGATGACT ATGAACTGCA GAGCTGGTGT 
CAAGAGATCA CTGAGATTGG GTTGCAAGGT GCCCAGGACA GAGGCTTCCC CACCTCCCTC 
CAGTCCCGGG CTCAGGCTTG CCACTTCATC ACCATGTGCA TCTTCACATG CACTGCGCAG 
CACTCTTCCA TCCATCTTGG CCAGCTGGAT TGGTTCTACT GGGTTCCTAA TGCACCCTGC 
ACCATGCGGC TGCCACCACC TAAAACCAAG GACGCGACGA TGGAGAAGCT GATGGCGACG 
CTGCCCAATC CTAATCAGTC TACTCTCCAG ATAAATGTCG TTTGGCTCCT GGGCAGACGC 
CAGGCTGTTA TGGTGCCCCT GGGCCAGCAT TCAGAGGAAC ACTTCCCAAA CCCTGAGGCC 
AAAGCTGTGC TGAAGAAGTT CAGAGAGGAG CTGGCTGCCT TGGATAAGGA AATTGAGATT 
CGTAACAAGA GCTTGGACAT ACCTTATGAG TACCTGCGGC CCAGCCTGGT AGAAAACAGC 
GTGGCCATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033790.3
CDS	27..2018
Translation	MGVYRIRVSTGDSVYAGSNNEVYLWLIGQHGEASLGKLFRPCRNSEAEFKVDVSEYLGPLLFVRVQKWHYLKEDAWFCNWISVKGPGDQGSEYTFPCYRWVQGTSILNLPEGTGCTVVEDSQGLFRNHREEELEERRSLYRWGNWKDGTILNVAATSISDLPVDQRFREDKRLEFEASQVLGTMDTVINFPKNTVTCWKSLDDFNYVFKSGHTKMAERVRNSWKEDAFFGYQFLNGANPMVLKRSTCLPARLVFPPGMEKLQAQLDEELKKGTLFEADFFLLDGIKANVILCSQQYLAAPLVMLKLQPDGQLLPIAIQLELPKTGSTPPPIFTPLDPPMDWLLAKCWVRSSDLQLHELQAHLLRGHLVAEVFAVATMRCLPSVHPVFKLLVPHLLYTMEINVRARSDLISERGFFDKVMSTGGGGHLDLLKQAGAFLTYSSLCPPDDLAERGLLDIDTCFYAKDALQLWQVMNRYVVGMFDLYYKTDQAVQDDYELQSWCQEITEIGLQGAQDRGFPTSLQSRAQACHFITMCIFTCTAQHSSIHLGQLDWFYWVPNAPCTMRLPPPKTKDATMEKLMATLPNPNQSTLQINVVWLLGRRQAVMVPLGQHSEEHFPNPEAKAVLKKFREELAALDKEIEIRNKSLDIPYEYLRPSLVENSVAI

Target ORF information:

RefSeq Version	NM_009660.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus arachidonate 15-lipoxygenase (Alox15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009660.3

ORF Insert Sequence:

ATGGGTGTCT ACCGCATCCG CGTCTCCACC GGGGACTCCG TGTACGCGGG CTCCAACAAC 
GAGGTCTACC TGTGGTTGAT CGGACAGCAT GGGGAGGCAT CTCTCGGGAA GCTGTTCCGA 
CCCTGTCGGA ACTCGGAGGC AGAATTCAAG GTGGATGTGT CAGAATACCT TGGGCCACTG 
CTGTTTGTGA GAGTGCAGAA ATGGCATTAT CTCAAAGAGG ACGCCTGGTT CTGCAACTGG 
ATTTCTGTGA AGGGCCCCGG AGACCAGGGA TCGGAGTACA CGTTCCCCTG TTACCGATGG 
GTTCAGGGCA CCAGCATCCT GAACCTCCCT GAGGGCACTG GCTGCACCGT GGTTGAAGAC 
TCTCAAGGCC TGTTCAGGAA CCACAGGGAG GAGGAACTGG AAGAAAGGAG GAGTCTGTAC 
AGGTGGGGCA ACTGGAAGGA TGGCACAATC CTGAACGTGG CGGCGACCAG TATCTCTGAC 
CTCCCTGTAG ACCAGCGATT TCGAGAGGAC AAAAGACTTG AATTTGAAGC TTCACAGGTT 
CTGGGGACAA TGGACACCGT TATTAACTTC CCTAAAAACA CTGTGACCTG CTGGAAAAGC 
CTAGATGACT TCAACTATGT TTTCAAGAGT GGCCACACCA AGATGGCTGA GCGGGTTCGA 
AACTCCTGGA AAGAGGATGC TTTCTTTGGG TACCAGTTTC TCAATGGTGC TAACCCCATG 
GTGCTGAAGC GGTCTACTTG TCTCCCTGCC CGCCTGGTAT TCCCTCCGGG GATGGAGAAG 
CTACAGGCCC AGCTGGATGA GGAGCTCAAG AAAGGCACTC TGTTTGAAGC GGATTTCTTC 
CTTCTGGATG GGATCAAGGC CAATGTCATC CTTTGTAGTC AGCAGTACCT GGCTGCCCCC 
CTCGTCATGC TGAAGCTGCA GCCCGATGGG CAACTCTTGC CTATAGCCAT CCAGCTCGAA 
CTGCCCAAAA CTGGGTCTAC CCCACCGCCG ATTTTCACGC CCTTGGATCC CCCAATGGAC 
TGGCTCCTGG CCAAATGCTG GGTCCGAAGC TCAGACTTAC AGCTTCATGA GCTACAGGCT 
CATCTTCTGA GGGGACACTT GGTGGCTGAG GTCTTTGCTG TGGCCACCAT GAGGTGCCTG 
CCTTCCGTGC ACCCTGTTTT TAAGCTTCTA GTTCCTCACC TACTCTACAC CATGGAAATC 
AATGTCCGGG CCAGGAGCGA CCTGATCTCA GAGAGAGGCT TTTTTGACAA GGTGATGAGC 
ACAGGTGGAG GAGGCCACCT GGATCTTCTC AAGCAAGCTG GAGCCTTCCT GACCTACAGC 
TCATTGTGTC CCCCTGATGA CTTGGCTGAG CGAGGACTCC TGGATATTGA CACTTGCTTC 
TATGCTAAAG ATGCCCTGCA GCTCTGGCAA GTCATGAATC GGTACGTGGT GGGAATGTTC 
GATCTCTACT ACAAGACCGA CCAAGCTGTT CAGGATGACT ATGAACTGCA GAGCTGGTGT 
CAAGAGATCA CTGAGATTGG GTTGCAAGGT GCCCAGGACA GAGGCTTCCC CACCTCCCTC 
CAGTCCCGGG CTCAGGCTTG CCACTTCATC ACCATGTGCA TCTTCACATG CACTGCGCAG 
CACTCTTCCA TCCATCTTGG CCAGCTGGAT TGGTTCTACT GGGTTCCTAA TGCACCCTGC 
ACCATGCGGC TGCCACCACC TAAAACCAAG GACGCGACGA TGGAGAAGCT GATGGCGACG 
CTGCCCAATC CTAATCAGTC TACTCTCCAG ATAAATGTCG TTTGGCTCCT GGGCAGACGC 
CAGGCTGTTA TGGTGCCCCT GGGCCAGCAT TCAGAGGAAC ACTTCCCAAA CCCTGAGGCC 
AAAGCTGTGC TGAAGAAGTT CAGAGAGGAG CTGGCTGCCT TGGATAAGGA AATTGAGATT 
CGTAACAAGA GCTTGGACAT ACCTTATGAG TACCTGCGGC CCAGCCTGGT AGAAAACAGC 
GTGGCCATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Alox15 ( XM_006532036.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006532099.1 Mus musculus arachidonate 15-lipoxygenase (Alox15), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu45440
Clone ID Related Accession (Same CDS sequence)	XM_006532036.4 , XM_006532036.3
Accession Version	XM_006532036.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2082bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	arachidonate 15-lipoxygenase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006532036.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGCTTT CTGACCACCT TGTCGGCATC TCAACTGAAG AGTCGTCACT CTCCAAGTGT 
TGTTCAAAGG GAGAAAACTT CATCTGCAAG ATGGGTGTCT ACCGCATCCG CGTCTCCACC 
GGGGACTCCG TGTACGCGGG CTCCAACAAC GAGGTCTACC TGTGGTTGAT CGGACAGCAT 
GGGGAGGCAT CTCTCGGGAA GCTGTTCCGA CCCTGTCGGA ACTCGGAGGC AGAATTCAAG 
GTGGATGTGT CAGAATACCT TGGGCCACTG CTGTTTGTGA GAGTGCAGAA ATGGCATTAT 
CTCAAAGAGG ACGCCTGGTT CTGCAACTGG ATTTCTGTGA AGGGCCCCGG AGACCAGGGA 
TCGGAGTACA CGTTCCCCTG TTACCGATGG GTTCAGGGCA CCAGCATCCT GAACCTCCCT 
GAGGGCACTG GCTGCACCGT GGTTGAAGAC TCTCAAGGCC TGTTCAGGAA CCACAGGGAG 
GAGGAACTGG AAGAAAGGAG GAGTCTGTAC AGGTGGGGCA ACTGGAAGGA TGGCACAATC 
CTGAACGTGG CGGCGACCAG TATCTCTGAC CTCCCTGTAG ACCAGCGATT TCGAGAGGAC 
AAAAGACTTG AATTTGAAGC TTCACAGGTT CTGGGGACAA TGGACACCGT TATTAACTTC 
CCTAAAAACA CTGTGACCTG CTGGAAAAGC CTAGATGACT TCAACTATGT TTTCAAGAGT 
GGCCACACCA AGATGGCTGA GCGGGTTCGA AACTCCTGGA AAGAGGATGC TTTCTTTGGG 
TACCAGTTTC TCAATGGTGC TAACCCCATG GTGCTGAAGC GGTCTACTTG TCTCCCTGCC 
CGCCTGGTAT TCCCTCCGGG GATGGAGAAG CTACAGGCCC AGCTGGATGA GGAGCTCAAG 
AAAGGCACTC TGTTTGAAGC GGATTTCTTC CTTCTGGATG GGATCAAGGC CAATGTCATC 
CTTTGTAGTC AGCAGTACCT GGCTGCCCCC CTCGTCATGC TGAAGCTGCA GCCCGATGGG 
CAACTCTTGC CTATAGCCAT CCAGCTCGAA CTGCCCAAAA CTGGGTCTAC CCCACCGCCG 
ATTTTCACGC CCTTGGATCC CCCAATGGAC TGGCTCCTGG CCAAATGCTG GGTCCGAAGC 
TCAGACTTAC AGCTTCATGA GCTACAGGCT CATCTTCTGA GGGGACACTT GGTGGCTGAG 
GTCTTTGCTG TGGCCACCAT GAGGTGCCTG CCTTCCGTGC ACCCTGTTTT TAAGCTTCTA 
GTTCCTCACC TACTCTACAC CATGGAAATC AATGTCCGGG CCAGGAGCGA CCTGATCTCA 
GAGAGAGGCT TTTTTGACAA GGTGATGAGC ACAGGTGGAG GAGGCCACCT GGATCTTCTC 
AAGCAAGCTG GAGCCTTCCT GACCTACAGC TCATTGTGTC CCCCTGATGA CTTGGCTGAG 
CGAGGACTCC TGGATATTGA CACTTGCTTC TATGCTAAAG ATGCCCTGCA GCTCTGGCAA 
GTCATGAATC GGTACGTGGT GGGAATGTTC GATCTCTACT ACAAGACCGA CCAAGCTGTT 
CAGGATGACT ATGAACTGCA GAGCTGGTGT CAAGAGATCA CTGAGATTGG GTTGCAAGGT 
GCCCAGGACA GAGGCTTCCC CACCTCCCTC CAGTCCCGGG CTCAGGCTTG CCACTTCATC 
ACCATGTGCA TCTTCACATG CACTGCGCAG CACTCTTCCA TCCATCTTGG CCAGCTGGAT 
TGGTTCTACT GGGTTCCTAA TGCACCCTGC ACCATGCGGC TGCCACCACC TAAAACCAAG 
GACGCGACGA TGGAGAAGCT GATGGCGACG CTGCCCAATC CTAATCAGTC TACTCTCCAG 
ATAAATGTCG TTTGGCTCCT GGGCAGACGC CAGGCTGTTA TGGTGCCCCT GGGCCAGCAT 
TCAGAGGAAC ACTTCCCAAA CCCTGAGGCC AAAGCTGTGC TGAAGAAGTT CAGAGAGGAG 
CTGGCTGCCT TGGATAAGGA AATTGAGATT CGTAACAAGA GCTTGGACAT ACCTTATGAG 
TACCTGCGGC CCAGCCTGGT AGAAAACAGC GTGGCCATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006532099.1
CDS	14711..16792
Translation	MQLSDHLVGISTEESSLSKCCSKGENFICKMGVYRIRVSTGDSVYAGSNNEVYLWLIGQHGEASLGKLFRPCRNSEAEFKVDVSEYLGPLLFVRVQKWHYLKEDAWFCNWISVKGPGDQGSEYTFPCYRWVQGTSILNLPEGTGCTVVEDSQGLFRNHREEELEERRSLYRWGNWKDGTILNVAATSISDLPVDQRFREDKRLEFEASQVLGTMDTVINFPKNTVTCWKSLDDFNYVFKSGHTKMAERVRNSWKEDAFFGYQFLNGANPMVLKRSTCLPARLVFPPGMEKLQAQLDEELKKGTLFEADFFLLDGIKANVILCSQQYLAAPLVMLKLQPDGQLLPIAIQLELPKTGSTPPPIFTPLDPPMDWLLAKCWVRSSDLQLHELQAHLLRGHLVAEVFAVATMRCLPSVHPVFKLLVPHLLYTMEINVRARSDLISERGFFDKVMSTGGGGHLDLLKQAGAFLTYSSLCPPDDLAERGLLDIDTCFYAKDALQLWQVMNRYVVGMFDLYYKTDQAVQDDYELQSWCQEITEIGLQGAQDRGFPTSLQSRAQACHFITMCIFTCTAQHSSIHLGQLDWFYWVPNAPCTMRLPPPKTKDATMEKLMATLPNPNQSTLQINVVWLLGRRQAVMVPLGQHSEEHFPNPEAKAVLKKFREELAALDKEIEIRNKSLDIPYEYLRPSLVENSVAI

Target ORF information:

RefSeq Version	XM_006532036.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus arachidonate 15-lipoxygenase (Alox15), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006532036.4

ORF Insert Sequence:

ATGCAGCTTT CTGACCACCT TGTCGGCATC TCAACTGAAG AGTCGTCACT CTCCAAGTGT 
TGTTCAAAGG GAGAAAACTT CATCTGCAAG ATGGGTGTCT ACCGCATCCG CGTCTCCACC 
GGGGACTCCG TGTACGCGGG CTCCAACAAC GAGGTCTACC TGTGGTTGAT CGGACAGCAT 
GGGGAGGCAT CTCTCGGGAA GCTGTTCCGA CCCTGTCGGA ACTCGGAGGC AGAATTCAAG 
GTGGATGTGT CAGAATACCT TGGGCCACTG CTGTTTGTGA GAGTGCAGAA ATGGCATTAT 
CTCAAAGAGG ACGCCTGGTT CTGCAACTGG ATTTCTGTGA AGGGCCCCGG AGACCAGGGA 
TCGGAGTACA CGTTCCCCTG TTACCGATGG GTTCAGGGCA CCAGCATCCT GAACCTCCCT 
GAGGGCACTG GCTGCACCGT GGTTGAAGAC TCTCAAGGCC TGTTCAGGAA CCACAGGGAG 
GAGGAACTGG AAGAAAGGAG GAGTCTGTAC AGGTGGGGCA ACTGGAAGGA TGGCACAATC 
CTGAACGTGG CGGCGACCAG TATCTCTGAC CTCCCTGTAG ACCAGCGATT TCGAGAGGAC 
AAAAGACTTG AATTTGAAGC TTCACAGGTT CTGGGGACAA TGGACACCGT TATTAACTTC 
CCTAAAAACA CTGTGACCTG CTGGAAAAGC CTAGATGACT TCAACTATGT TTTCAAGAGT 
GGCCACACCA AGATGGCTGA GCGGGTTCGA AACTCCTGGA AAGAGGATGC TTTCTTTGGG 
TACCAGTTTC TCAATGGTGC TAACCCCATG GTGCTGAAGC GGTCTACTTG TCTCCCTGCC 
CGCCTGGTAT TCCCTCCGGG GATGGAGAAG CTACAGGCCC AGCTGGATGA GGAGCTCAAG 
AAAGGCACTC TGTTTGAAGC GGATTTCTTC CTTCTGGATG GGATCAAGGC CAATGTCATC 
CTTTGTAGTC AGCAGTACCT GGCTGCCCCC CTCGTCATGC TGAAGCTGCA GCCCGATGGG 
CAACTCTTGC CTATAGCCAT CCAGCTCGAA CTGCCCAAAA CTGGGTCTAC CCCACCGCCG 
ATTTTCACGC CCTTGGATCC CCCAATGGAC TGGCTCCTGG CCAAATGCTG GGTCCGAAGC 
TCAGACTTAC AGCTTCATGA GCTACAGGCT CATCTTCTGA GGGGACACTT GGTGGCTGAG 
GTCTTTGCTG TGGCCACCAT GAGGTGCCTG CCTTCCGTGC ACCCTGTTTT TAAGCTTCTA 
GTTCCTCACC TACTCTACAC CATGGAAATC AATGTCCGGG CCAGGAGCGA CCTGATCTCA 
GAGAGAGGCT TTTTTGACAA GGTGATGAGC ACAGGTGGAG GAGGCCACCT GGATCTTCTC 
AAGCAAGCTG GAGCCTTCCT GACCTACAGC TCATTGTGTC CCCCTGATGA CTTGGCTGAG 
CGAGGACTCC TGGATATTGA CACTTGCTTC TATGCTAAAG ATGCCCTGCA GCTCTGGCAA 
GTCATGAATC GGTACGTGGT GGGAATGTTC GATCTCTACT ACAAGACCGA CCAAGCTGTT 
CAGGATGACT ATGAACTGCA GAGCTGGTGT CAAGAGATCA CTGAGATTGG GTTGCAAGGT 
GCCCAGGACA GAGGCTTCCC CACCTCCCTC CAGTCCCGGG CTCAGGCTTG CCACTTCATC 
ACCATGTGCA TCTTCACATG CACTGCGCAG CACTCTTCCA TCCATCTTGG CCAGCTGGAT 
TGGTTCTACT GGGTTCCTAA TGCACCCTGC ACCATGCGGC TGCCACCACC TAAAACCAAG 
GACGCGACGA TGGAGAAGCT GATGGCGACG CTGCCCAATC CTAATCAGTC TACTCTCCAG 
ATAAATGTCG TTTGGCTCCT GGGCAGACGC CAGGCTGTTA TGGTGCCCCT GGGCCAGCAT 
TCAGAGGAAC ACTTCCCAAA CCCTGAGGCC AAAGCTGTGC TGAAGAAGTT CAGAGAGGAG 
CTGGCTGCCT TGGATAAGGA AATTGAGATT CGTAACAAGA GCTTGGACAT ACCTTATGAG 
TACCTGCGGC CCAGCCTGGT AGAAAACAGC GTGGCCATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Alox15 ( XM_006532036.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006532099.1 Mus musculus arachidonate 15-lipoxygenase (Alox15), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu45440
Clone ID Related Accession (Same CDS sequence)	XM_006532036.4 , XM_006532036.3
Accession Version	XM_006532036.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2082bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1466438400000
Organism	Mus musculus(house mouse)
Product	arachidonate 15-lipoxygenase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006532036.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGCTTT CTGACCACCT TGTCGGCATC TCAACTGAAG AGTCGTCACT CTCCAAGTGT 
TGTTCAAAGG GAGAAAACTT CATCTGCAAG ATGGGTGTCT ACCGCATCCG CGTCTCCACC 
GGGGACTCCG TGTACGCGGG CTCCAACAAC GAGGTCTACC TGTGGTTGAT CGGACAGCAT 
GGGGAGGCAT CTCTCGGGAA GCTGTTCCGA CCCTGTCGGA ACTCGGAGGC AGAATTCAAG 
GTGGATGTGT CAGAATACCT TGGGCCACTG CTGTTTGTGA GAGTGCAGAA ATGGCATTAT 
CTCAAAGAGG ACGCCTGGTT CTGCAACTGG ATTTCTGTGA AGGGCCCCGG AGACCAGGGA 
TCGGAGTACA CGTTCCCCTG TTACCGATGG GTTCAGGGCA CCAGCATCCT GAACCTCCCT 
GAGGGCACTG GCTGCACCGT GGTTGAAGAC TCTCAAGGCC TGTTCAGGAA CCACAGGGAG 
GAGGAACTGG AAGAAAGGAG GAGTCTGTAC AGGTGGGGCA ACTGGAAGGA TGGCACAATC 
CTGAACGTGG CGGCGACCAG TATCTCTGAC CTCCCTGTAG ACCAGCGATT TCGAGAGGAC 
AAAAGACTTG AATTTGAAGC TTCACAGGTT CTGGGGACAA TGGACACCGT TATTAACTTC 
CCTAAAAACA CTGTGACCTG CTGGAAAAGC CTAGATGACT TCAACTATGT TTTCAAGAGT 
GGCCACACCA AGATGGCTGA GCGGGTTCGA AACTCCTGGA AAGAGGATGC TTTCTTTGGG 
TACCAGTTTC TCAATGGTGC TAACCCCATG GTGCTGAAGC GGTCTACTTG TCTCCCTGCC 
CGCCTGGTAT TCCCTCCGGG GATGGAGAAG CTACAGGCCC AGCTGGATGA GGAGCTCAAG 
AAAGGCACTC TGTTTGAAGC GGATTTCTTC CTTCTGGATG GGATCAAGGC CAATGTCATC 
CTTTGTAGTC AGCAGTACCT GGCTGCCCCC CTCGTCATGC TGAAGCTGCA GCCCGATGGG 
CAACTCTTGC CTATAGCCAT CCAGCTCGAA CTGCCCAAAA CTGGGTCTAC CCCACCGCCG 
ATTTTCACGC CCTTGGATCC CCCAATGGAC TGGCTCCTGG CCAAATGCTG GGTCCGAAGC 
TCAGACTTAC AGCTTCATGA GCTACAGGCT CATCTTCTGA GGGGACACTT GGTGGCTGAG 
GTCTTTGCTG TGGCCACCAT GAGGTGCCTG CCTTCCGTGC ACCCTGTTTT TAAGCTTCTA 
GTTCCTCACC TACTCTACAC CATGGAAATC AATGTCCGGG CCAGGAGCGA CCTGATCTCA 
GAGAGAGGCT TTTTTGACAA GGTGATGAGC ACAGGTGGAG GAGGCCACCT GGATCTTCTC 
AAGCAAGCTG GAGCCTTCCT GACCTACAGC TCATTGTGTC CCCCTGATGA CTTGGCTGAG 
CGAGGACTCC TGGATATTGA CACTTGCTTC TATGCTAAAG ATGCCCTGCA GCTCTGGCAA 
GTCATGAATC GGTACGTGGT GGGAATGTTC GATCTCTACT ACAAGACCGA CCAAGCTGTT 
CAGGATGACT ATGAACTGCA GAGCTGGTGT CAAGAGATCA CTGAGATTGG GTTGCAAGGT 
GCCCAGGACA GAGGCTTCCC CACCTCCCTC CAGTCCCGGG CTCAGGCTTG CCACTTCATC 
ACCATGTGCA TCTTCACATG CACTGCGCAG CACTCTTCCA TCCATCTTGG CCAGCTGGAT 
TGGTTCTACT GGGTTCCTAA TGCACCCTGC ACCATGCGGC TGCCACCACC TAAAACCAAG 
GACGCGACGA TGGAGAAGCT GATGGCGACG CTGCCCAATC CTAATCAGTC TACTCTCCAG 
ATAAATGTCG TTTGGCTCCT GGGCAGACGC CAGGCTGTTA TGGTGCCCCT GGGCCAGCAT 
TCAGAGGAAC ACTTCCCAAA CCCTGAGGCC AAAGCTGTGC TGAAGAAGTT CAGAGAGGAG 
CTGGCTGCCT TGGATAAGGA AATTGAGATT CGTAACAAGA GCTTGGACAT ACCTTATGAG 
TACCTGCGGC CCAGCCTGGT AGAAAACAGC GTGGCCATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006532099.1
CDS	6808..8889
Translation	MQLSDHLVGISTEESSLSKCCSKGENFICKMGVYRIRVSTGDSVYAGSNNEVYLWLIGQHGEASLGKLFRPCRNSEAEFKVDVSEYLGPLLFVRVQKWHYLKEDAWFCNWISVKGPGDQGSEYTFPCYRWVQGTSILNLPEGTGCTVVEDSQGLFRNHREEELEERRSLYRWGNWKDGTILNVAATSISDLPVDQRFREDKRLEFEASQVLGTMDTVINFPKNTVTCWKSLDDFNYVFKSGHTKMAERVRNSWKEDAFFGYQFLNGANPMVLKRSTCLPARLVFPPGMEKLQAQLDEELKKGTLFEADFFLLDGIKANVILCSQQYLAAPLVMLKLQPDGQLLPIAIQLELPKTGSTPPPIFTPLDPPMDWLLAKCWVRSSDLQLHELQAHLLRGHLVAEVFAVATMRCLPSVHPVFKLLVPHLLYTMEINVRARSDLISERGFFDKVMSTGGGGHLDLLKQAGAFLTYSSLCPPDDLAERGLLDIDTCFYAKDALQLWQVMNRYVVGMFDLYYKTDQAVQDDYELQSWCQEITEIGLQGAQDRGFPTSLQSRAQACHFITMCIFTCTAQHSSIHLGQLDWFYWVPNAPCTMRLPPPKTKDATMEKLMATLPNPNQSTLQINVVWLLGRRQAVMVPLGQHSEEHFPNPEAKAVLKKFREELAALDKEIEIRNKSLDIPYEYLRPSLVENSVAI

Target ORF information:

RefSeq Version	XM_006532036.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus arachidonate 15-lipoxygenase (Alox15), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006532036.3

ORF Insert Sequence:

ATGCAGCTTT CTGACCACCT TGTCGGCATC TCAACTGAAG AGTCGTCACT CTCCAAGTGT 
TGTTCAAAGG GAGAAAACTT CATCTGCAAG ATGGGTGTCT ACCGCATCCG CGTCTCCACC 
GGGGACTCCG TGTACGCGGG CTCCAACAAC GAGGTCTACC TGTGGTTGAT CGGACAGCAT 
GGGGAGGCAT CTCTCGGGAA GCTGTTCCGA CCCTGTCGGA ACTCGGAGGC AGAATTCAAG 
GTGGATGTGT CAGAATACCT TGGGCCACTG CTGTTTGTGA GAGTGCAGAA ATGGCATTAT 
CTCAAAGAGG ACGCCTGGTT CTGCAACTGG ATTTCTGTGA AGGGCCCCGG AGACCAGGGA 
TCGGAGTACA CGTTCCCCTG TTACCGATGG GTTCAGGGCA CCAGCATCCT GAACCTCCCT 
GAGGGCACTG GCTGCACCGT GGTTGAAGAC TCTCAAGGCC TGTTCAGGAA CCACAGGGAG 
GAGGAACTGG AAGAAAGGAG GAGTCTGTAC AGGTGGGGCA ACTGGAAGGA TGGCACAATC 
CTGAACGTGG CGGCGACCAG TATCTCTGAC CTCCCTGTAG ACCAGCGATT TCGAGAGGAC 
AAAAGACTTG AATTTGAAGC TTCACAGGTT CTGGGGACAA TGGACACCGT TATTAACTTC 
CCTAAAAACA CTGTGACCTG CTGGAAAAGC CTAGATGACT TCAACTATGT TTTCAAGAGT 
GGCCACACCA AGATGGCTGA GCGGGTTCGA AACTCCTGGA AAGAGGATGC TTTCTTTGGG 
TACCAGTTTC TCAATGGTGC TAACCCCATG GTGCTGAAGC GGTCTACTTG TCTCCCTGCC 
CGCCTGGTAT TCCCTCCGGG GATGGAGAAG CTACAGGCCC AGCTGGATGA GGAGCTCAAG 
AAAGGCACTC TGTTTGAAGC GGATTTCTTC CTTCTGGATG GGATCAAGGC CAATGTCATC 
CTTTGTAGTC AGCAGTACCT GGCTGCCCCC CTCGTCATGC TGAAGCTGCA GCCCGATGGG 
CAACTCTTGC CTATAGCCAT CCAGCTCGAA CTGCCCAAAA CTGGGTCTAC CCCACCGCCG 
ATTTTCACGC CCTTGGATCC CCCAATGGAC TGGCTCCTGG CCAAATGCTG GGTCCGAAGC 
TCAGACTTAC AGCTTCATGA GCTACAGGCT CATCTTCTGA GGGGACACTT GGTGGCTGAG 
GTCTTTGCTG TGGCCACCAT GAGGTGCCTG CCTTCCGTGC ACCCTGTTTT TAAGCTTCTA 
GTTCCTCACC TACTCTACAC CATGGAAATC AATGTCCGGG CCAGGAGCGA CCTGATCTCA 
GAGAGAGGCT TTTTTGACAA GGTGATGAGC ACAGGTGGAG GAGGCCACCT GGATCTTCTC 
AAGCAAGCTG GAGCCTTCCT GACCTACAGC TCATTGTGTC CCCCTGATGA CTTGGCTGAG 
CGAGGACTCC TGGATATTGA CACTTGCTTC TATGCTAAAG ATGCCCTGCA GCTCTGGCAA 
GTCATGAATC GGTACGTGGT GGGAATGTTC GATCTCTACT ACAAGACCGA CCAAGCTGTT 
CAGGATGACT ATGAACTGCA GAGCTGGTGT CAAGAGATCA CTGAGATTGG GTTGCAAGGT 
GCCCAGGACA GAGGCTTCCC CACCTCCCTC CAGTCCCGGG CTCAGGCTTG CCACTTCATC 
ACCATGTGCA TCTTCACATG CACTGCGCAG CACTCTTCCA TCCATCTTGG CCAGCTGGAT 
TGGTTCTACT GGGTTCCTAA TGCACCCTGC ACCATGCGGC TGCCACCACC TAAAACCAAG 
GACGCGACGA TGGAGAAGCT GATGGCGACG CTGCCCAATC CTAATCAGTC TACTCTCCAG 
ATAAATGTCG TTTGGCTCCT GGGCAGACGC CAGGCTGTTA TGGTGCCCCT GGGCCAGCAT 
TCAGAGGAAC ACTTCCCAAA CCCTGAGGCC AAAGCTGTGC TGAAGAAGTT CAGAGAGGAG 
CTGGCTGCCT TGGATAAGGA AATTGAGATT CGTAACAAGA GCTTGGACAT ACCTTATGAG 
TACCTGCGGC CCAGCCTGGT AGAAAACAGC GTGGCCATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet β cells.
The Journal of biological chemistry294(16)6612-6620(2019 04)
Conteh AM,Reissaus CA,Hernandez-Perez M,Nakshatri S,Anderson RM,Mirmira RG,Tersey SA,Linnemann AK

Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage.
Stroke50(2)520-523(2019 02)
Gaberel T,Gakuba C,Zheng Y,Lépine M,Lo EH,van Leyen K

Immunoregulatory role of 15-lipoxygenase in the pathogenesis of bacterial keratitis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology32(9)5026-5038(2018 09)
Carion TW,Greenwood M,Ebrahim AS,Jerome A,Suvas S,Gronert K,Berger EA

MMP-2 and MMP-9 contribute to the angiogenic effect produced by hypoxia/15-HETE in pulmonary endothelial cells.
Journal of molecular and cellular cardiology12136-50(2018 08)
Liu Y,Zhang H,Yan L,Du W,Zhang M,Chen H,Zhang L,Li G,Li J,Dong Y,Zhu D

Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase.
PloS one13(8)e0201369(2018)
Hinman A,Holst CR,Latham JC,Bruegger JJ,Ulas G,McCusker KP,Amagata A,Davis D,Hoff KG,Kahn-Kirby AH,Kim V,Kosaka Y,Lee E,Malone SA,Mei JJ,Richards SJ,Rivera V,Miller G,Trimmer JK,Shrader WD

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Alox15 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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